format-version: 1.2 data-version: go/releases/2025-01-23/imports/pr_import.owl ontology: go/imports/pr_import [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB] comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB). synonym: "native protein" NARROW [IEDB:BP] synonym: "natural protein" EXACT [PRO:DAN] is_a: PR:000018263 ! amino acid chain is_a: PR:000064867 ! protein-containing molecular entity intersection_of: PR:000018263 ! amino acid chain intersection_of: has_gene_template SO:0000704 intersection_of: RO:0002353 GO:0006412 relationship: BFO:0000051 PR:000000001 ! protein relationship: has_gene_template SO:0000704 relationship: RO:0002353 GO:0006412 [Term] id: PR:000000008 name: TGF-beta-like cystine-knot cytokine namespace: protein def: "A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain." [PRO:CNA] comment: Category=family. synonym: "TGF-beta superfamily" RELATED [] xref: PIRSF:PIRSF800009 is_a: PR:000000001 ! protein [Term] id: PR:000000017 name: interferon gamma namespace: protein def: "A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA] comment: Category=gene. synonym: "IFN-gamma" EXACT [] synonym: "IFNG" EXACT PRO-short-label [PRO:DNx] synonym: "immune interferon" EXACT [] xref: PIRSF:PIRSF001936 is_a: PR:000024990 ! type II interferon [Term] id: PR:000000019 name: mitogen-activated protein kinase namespace: protein def: "A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase] comment: Category=family. synonym: "kinase-related transforming protein" RELATED [] synonym: "MAPK" EXACT [] xref: PIRSF:PIRSF501110 is_a: PR:000000001 ! protein [Term] id: PR:000000028 name: small GTPase namespace: protein def: "A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches." [PMID:15731001] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000000033 name: tumor necrosis factor, TNF-like namespace: protein def: "A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229)." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF001873 is_a: PR:000000001 ! protein [Term] id: PR:000000034 name: bone morphogenetic protein namespace: protein def: "A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors." [PIRSF:PIRSF037272] comment: Category=family. xref: PIRSF:PIRSF037272 is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000000046 name: TGF-beta namespace: protein def: "A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation." [PIRSF:PIRSF001787] comment: Category=family. synonym: "transforming growth factor beta" EXACT [] xref: PIRSF:PIRSF001787 is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000000105 name: nodal protein namespace: protein def: "A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA] comment: Category=gene. synonym: "NODAL" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF037400 is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000001004 name: CD4 molecule namespace: protein def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [PMID:15326605] comment: Category=gene. Requested by=CL. synonym: "CD4" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] xref: PIRSF:PIRSF001977 is_a: PR:000000001 ! protein [Term] id: PR:000001091 name: interleukin-1 namespace: protein def: "A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain." [PMID:8001745, PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF001937 is_a: PR:000000001 ! protein [Term] id: PR:000001092 name: interleukin-17 namespace: protein def: "A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [PMID:17982105, PMID:18280574] comment: Category=family. synonym: "fam:IL-17" EXACT PRO-short-label [PRO:DAN] synonym: "IL17" EXACT [] xref: PIRSF:PIRSF003430 is_a: PR:000000001 ! protein [Term] id: PR:000001094 name: rhodopsin-like G-protein coupled receptor namespace: protein def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [PMID:12761335, PRO:DAN, PRO:WCB] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "class 1 G-protein coupled receptor" EXACT [PMID:15914470] synonym: "class A G-protein coupled receptor" EXACT [IUPHAR:GPCRListForward?class=A] synonym: "fam:rhodopsin" EXACT PRO-short-label [PRO:DAN] xref: IUPHAR:GPCRListForward?class=A xref: PIRSF:PIRSF800006 is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001095 name: secretin-like G-protein coupled receptor namespace: protein def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding." [PMID:15862553, PRO:WCB] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "class 2 G-protein coupled receptor" BROAD [PMID:15914470] synonym: "class B G-protein coupled receptor" EXACT [IUPHAR:GPCRListForward?class=B] synonym: "fam:secretin" EXACT PRO-short-label [PRO:DAN] synonym: "subfamily B1 G-protein coupled receptor" EXACT [PMID:11790261] xref: IUPHAR:GPCRListForward?class=B is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001096 name: Toll-like receptor namespace: protein def: "A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582)." [PMID:11022119] comment: Category=family. synonym: "fam:TLR" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF800008 is_a: PR:000000001 ! protein [Term] id: PR:000001105 name: C5a anaphylatoxin chemotactic receptor namespace: protein def: "A complement peptide receptor whose active form binds C5a anaphylatoxin." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038566 is_a: PR:000044643 ! complement peptide receptor [Term] id: PR:000001113 name: interleukin-25 namespace: protein def: "An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-17E" EXACT [] synonym: "IL-25" EXACT [] synonym: "IL17E" RELATED Gene-based [] synonym: "IL25" EXACT PRO-short-label [PRO:DNx] synonym: "interleukin-17E" EXACT [] synonym: "UNQ3120/PRO10272" RELATED Gene-based [] is_a: PR:000001092 ! interleukin-17 [Term] id: PR:000001115 name: alpha-1 adrenergic receptor namespace: protein def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system." [PRO:WCB, Wikipedia:Adrenergic_receptor] comment: Category=family. xref: PIRSF:PIRSF038550 is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001116 name: alpha-2 adrenergic receptor namespace: protein def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase." [PRO:WCB, Wikipedia:Adrenergic_receptor] comment: Category=family. xref: PIRSF:PIRSF038554 is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001119 name: animal opsin namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix." [PRO:WCB, PRO:XQ, Wikipedia:Opsin] comment: Category=family. synonym: "opsin receptor" EXACT [IUPHARfam:975] synonym: "type II opsin" EXACT [Wikipedia:Opsin] xref: IUPHARfam:975 xref: PIRSF:PIRSF038544 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor is_a: PR:000036194 ! eukaryotic protein relationship: RO:0002160 NCBITaxon:33208 [Term] id: PR:000001120 name: apelin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin." [PRO:WCB] comment: Category=gene. synonym: "AGTRL1" RELATED Gene-based [] synonym: "angiotensin receptor-like 1" EXACT [] synonym: "APJ" RELATED Gene-based [] synonym: "APLNR" EXACT PRO-short-label [PRO:DNx] synonym: "G-protein coupled receptor APJ" EXACT [] synonym: "G-protein coupled receptor HG11" EXACT [] synonym: "MSR" RELATED [] xref: IUPHARobj:36 xref: PIRSF:PIRSF038558 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001121 name: beta adrenergic receptor namespace: protein def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase." [PRO:WCB, Wikipedia:Adrenergic_receptor] comment: Category=family. xref: PIRSF:PIRSF038556 is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001122 name: bombesin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:9 xref: PIRSF:PIRSF038623 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001123 name: bradykinin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:10 xref: PIRSF:PIRSF038572 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001128 name: chemokine receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines." [PMID:12037138, PRO:WCB, PRO:XQ] comment: Category=family. Note: Only those that have been unequivocally shown to activate a G-protein coupled signaling pathway appear on the official IUPHAR list. xref: IUPHARfam:14 xref: PIRSF:PIRSF038545 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001130 name: cholecystokinin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK)." [PRO:WCB, PRO:XQ] comment: Category=family. synonym: "fam:CCK_R" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:15 xref: PIRSF:PIRSF038581 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001131 name: cysteinyl leukotriene receptor namespace: protein def: "A leukotriene receptor that in active form binds cysteinyl leukotriene." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038618 is_a: PR:000049997 ! leukotriene receptor [Term] id: PR:000001133 name: endothelin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins." [PRO:WCB, PRO:XQ] comment: Category=family. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). xref: IUPHARfam:21 xref: PIRSF:PIRSF001842 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001134 name: growth hormone secretagogue/motilin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038641 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001141 name: interleukin-17D namespace: protein def: "An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-17D" EXACT [] synonym: "IL-27" EXACT [] synonym: "IL17D" EXACT PRO-short-label [PRO:DNx] synonym: "IL27" RELATED [] synonym: "interleukin-27" EXACT [] synonym: "UNQ3096/PRO21175" RELATED Gene-based [] is_a: PR:000001092 ! interleukin-17 [Term] id: PR:000001146 name: melanocortin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone." [PRO:WCB, PRO:XQ, Wikipedia:Melanocortin] comment: Category=family. xref: IUPHARfam:38 xref: PIRSF:PIRSF005524 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001150 name: tachykinin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides." [PRO:WCB, PRO:XQ, Wikipedia:Tachykinin_peptides] comment: Category=family. xref: IUPHARfam:62 xref: PIRSF:PIRSF001840 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001153 name: Toll-like receptor 2 namespace: protein def: "A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "CD282" EXACT [] synonym: "TIL4" RELATED Gene-based [] synonym: "TLR2" EXACT PRO-short-label [PRO:DNx] synonym: "Toll/interleukin-1 receptor-like protein 4" EXACT [] xref: IUPHARobj:1752 is_a: PR:000001096 ! Toll-like receptor [Term] id: PR:000001155 name: Toll-like receptor 4 namespace: protein def: "A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "CD284" EXACT [] synonym: "Lps" RELATED Gene-based [] synonym: "TLR4" EXACT PRO-short-label [PRO:DNx] synonym: "Toll" BROAD [PRO:DAN] xref: IUPHARobj:1754 is_a: PR:000001096 ! Toll-like receptor [Term] id: PR:000001171 name: B1 bradykinin receptor namespace: protein def: "A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin." [PRO:WCB] comment: Category=gene. synonym: "B1R" EXACT [] synonym: "Bdkrb" RELATED Gene-based [] synonym: "BDKRB1" EXACT PRO-short-label [PRO:DNx] synonym: "BK-1 receptor" EXACT [] synonym: "BRADYB1" RELATED Gene-based [] xref: IUPHARobj:41 is_a: PR:000001123 ! bradykinin receptor [Term] id: PR:000001172 name: B2 bradykinin receptor namespace: protein def: "A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin." [PRO:WCB] comment: Category=gene. synonym: "B2R" EXACT [] synonym: "BDKRB2" EXACT PRO-short-label [PRO:DNx] synonym: "BK-2 receptor" EXACT [] synonym: "BKR2" RELATED Gene-based [] xref: IUPHARobj:42 is_a: PR:000001123 ! bradykinin receptor [Term] id: PR:000001182 name: adrenocorticotropic hormone receptor namespace: protein def: "A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH." [PRO:WCB] comment: Category=gene. synonym: "ACTH receptor" EXACT [] synonym: "ACTH-R" EXACT [] synonym: "ACTHR" RELATED Gene-based [] synonym: "adrenocorticotropin receptor" EXACT [] synonym: "MC2-R" EXACT [] synonym: "MC2R" EXACT PRO-short-label [PRO:DNx] synonym: "melanocortin receptor 2" EXACT [] xref: IUPHARobj:283 is_a: PR:000001146 ! melanocortin receptor [Term] id: PR:000001183 name: alpha-1A adrenergic receptor namespace: protein def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA1A" EXACT PRO-short-label [PRO:DNx] synonym: "ADRA1C" RELATED Gene-based [] synonym: "alpha-1A adrenoceptor" EXACT [] synonym: "alpha-1A adrenoreceptor" EXACT [] synonym: "alpha-1C adrenergic receptor" EXACT [] synonym: "alpha-adrenergic receptor 1c" EXACT [] xref: IUPHARobj:22 is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001184 name: alpha-1B adrenergic receptor namespace: protein def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA1B" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-1B adrenoceptor" EXACT [] synonym: "alpha-1B adrenoreceptor" EXACT [] xref: IUPHARobj:23 is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001185 name: alpha-1D adrenergic receptor namespace: protein def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA1A" RELATED Gene-based [] synonym: "ADRA1D" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-1A adrenergic receptor" RELATED [] synonym: "alpha-1D adrenoceptor" EXACT [] synonym: "alpha-1D adrenoreceptor" EXACT [] synonym: "alpha-adrenergic receptor 1a" EXACT [] synonym: "Gpcr8" RELATED Gene-based [] xref: IUPHARobj:24 is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001186 name: alpha-2A adrenergic receptor namespace: protein def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA2A" EXACT PRO-short-label [PRO:DNx] synonym: "ADRA2R" RELATED Gene-based [] synonym: "ADRAR" RELATED Gene-based [] synonym: "alpha-2 adrenergic receptor subtype C10" EXACT [] synonym: "alpha-2A adrenoceptor" EXACT [] synonym: "alpha-2A adrenoreceptor" EXACT [] synonym: "alpha-2AAR" EXACT [] xref: IUPHARobj:25 is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001187 name: alpha-2B adrenergic receptor namespace: protein def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA2B" EXACT PRO-short-label [PRO:DNx] synonym: "ADRA2L1" RELATED Gene-based [] synonym: "ADRA2RL1" RELATED Gene-based [] synonym: "alpha-2 adrenergic receptor subtype C2" EXACT [] synonym: "alpha-2B adrenoceptor" EXACT [] synonym: "alpha-2B adrenoreceptor" EXACT [] synonym: "alpha-2BAR" EXACT [] xref: IUPHARobj:26 is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001188 name: alpha-2C adrenergic receptor namespace: protein def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRA2C" EXACT PRO-short-label [PRO:DNx] synonym: "ADRA2L2" RELATED Gene-based [] synonym: "ADRA2RL2" RELATED Gene-based [] synonym: "alpha-2 adrenergic receptor subtype C4" EXACT [] synonym: "alpha-2C adrenoceptor" EXACT [] synonym: "alpha-2C adrenoreceptor" EXACT [] synonym: "alpha-2CAR" EXACT [] xref: IUPHARobj:27 is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001192 name: beta-1 adrenergic receptor namespace: protein def: "A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRB1" EXACT PRO-short-label [PRO:DNx] synonym: "ADRB1R" RELATED Gene-based [] synonym: "B1AR" RELATED Gene-based [] synonym: "beta-1 adrenoceptor" EXACT [] synonym: "beta-1 adrenoreceptor" EXACT [] xref: IUPHARobj:28 is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001193 name: beta-2 adrenergic receptor namespace: protein def: "A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRB2" EXACT PRO-short-label [PRO:DNx] synonym: "ADRB2R" RELATED Gene-based [] synonym: "B2AR" RELATED Gene-based [] synonym: "beta(2)-adrenergic receptor" EXACT [PMID:10567420] synonym: "beta-2 adrenoceptor" EXACT [] synonym: "beta-2 adrenoreceptor" EXACT [] xref: IUPHARobj:29 is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001194 name: beta-3 adrenergic receptor namespace: protein def: "A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "ADRB3" EXACT PRO-short-label [PRO:DNx] synonym: "ADRB3R" RELATED Gene-based [] synonym: "B3AR" RELATED Gene-based [] synonym: "B3bar" RELATED Gene-based [] synonym: "beta-3 adrenoceptor" EXACT [] synonym: "beta-3 adrenoreceptor" EXACT [] xref: IUPHARobj:30 is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001197 name: chemokine receptor CCR1/3/1L namespace: protein def: "A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN, PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF501024 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001199 name: C-C chemokine receptor type 2 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-2" EXACT [] synonym: "CC-CKR-2" EXACT [] synonym: "CCR-2" EXACT [] synonym: "CCR2" EXACT PRO-short-label [PRO:DNx] synonym: "CD192" EXACT [] synonym: "chemokine receptor CCR2" EXACT [] synonym: "CMKBR2" RELATED Gene-based [] synonym: "JE/FIC receptor" EXACT [] synonym: "MCP-1 receptor" EXACT [] synonym: "MCP-1-R" EXACT [] synonym: "monocyte chemoattractant protein 1 receptor" EXACT [] xref: IUPHARobj:59 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001202 name: C-C chemokine receptor type 6 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-6" EXACT [] synonym: "CC-CKR-6" EXACT [] synonym: "CCR-6" EXACT [] synonym: "CCR6" EXACT PRO-short-label [PRO:DNx] synonym: "CD196" EXACT [] synonym: "chemokine receptor CCR6" EXACT [] synonym: "chemokine receptor-like 3" EXACT [] synonym: "CKR-L3" EXACT [] synonym: "CKRL3" RELATED Gene-based [] synonym: "CMKBR6" RELATED Gene-based [] synonym: "DRY6" EXACT [] synonym: "G-protein coupled receptor 29" EXACT [] synonym: "GPR-CY4" EXACT [] synonym: "GPR29" RELATED Gene-based [] synonym: "GPRCY4" EXACT [] synonym: "KY411" EXACT [] synonym: "LARC receptor" EXACT [] synonym: "STRL22" RELATED Gene-based [] xref: IUPHARobj:63 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001203 name: C-C chemokine receptor type 7 namespace: protein def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "BLR2" EXACT [] synonym: "C-C CKR-7" EXACT [] synonym: "CC-CKR-7" EXACT [] synonym: "CCR-7" EXACT [] synonym: "CCR7" EXACT PRO-short-label [PRO:DNx] synonym: "CD197" EXACT [] synonym: "CDw197" EXACT [] synonym: "chemokine receptor CCR7" EXACT [] synonym: "CMKBR7" RELATED Gene-based [] synonym: "EBI1" RELATED Gene-based [] synonym: "Ebi1h" RELATED Gene-based [] synonym: "EBV-induced G-protein coupled receptor 1" EXACT [] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT [] synonym: "EVI1" RELATED Gene-based [] synonym: "MIP-3 beta receptor" EXACT [] xref: IUPHARobj:64 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001206 name: CX3C chemokine receptor 1 namespace: protein def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "beta chemokine receptor-like 1" EXACT [] synonym: "C-X3-C CKR-1" EXACT [] synonym: "chemokine receptor CX3CR1" EXACT [] synonym: "CMK-BRL-1" EXACT [] synonym: "CMK-BRL1" EXACT [] synonym: "CMKBRL1" RELATED Gene-based [] synonym: "CX3CR1" EXACT PRO-short-label [PRO:DNx] synonym: "fractalkine receptor" EXACT [] synonym: "G-protein coupled receptor 13" EXACT [] synonym: "GPR13" RELATED Gene-based [] synonym: "V28" EXACT [] xref: IUPHARobj:74 xref: PIRSF:PIRSF501025 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001208 name: C-X-C chemokine receptor type 4 namespace: protein def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD184" EXACT [] synonym: "chemokine receptor CXCR4" EXACT [] synonym: "Cmkar4" RELATED Gene-based [] synonym: "CXC-R4" EXACT [] synonym: "CXCR-4" EXACT [] synonym: "CXCR4" EXACT PRO-short-label [PRO:DNx] synonym: "FB22" EXACT [] synonym: "fusin" EXACT [] synonym: "HM89" EXACT [] synonym: "LCR1" EXACT [] synonym: "LESTR" EXACT [] synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT [] synonym: "NPYRL" EXACT [] synonym: "PB-CKR" EXACT [] synonym: "pre-B-cell-derived chemokine receptor" EXACT [] synonym: "SDF-1 receptor" EXACT [] synonym: "Sdf1r" RELATED Gene-based [] synonym: "stromal cell-derived factor 1 receptor" EXACT [] xref: IUPHARobj:71 xref: PIRSF:PIRSF501021 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001212 name: chemokine XC receptor 1 namespace: protein def: "A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2." [PMID:12037138, PRO:WCB] comment: Category=gene. synonym: "CCXCR1" RELATED Gene-based [] synonym: "chemokine receptor XCR1" EXACT [] synonym: "G-protein coupled receptor 5" EXACT [] synonym: "GPR5" RELATED Gene-based [] synonym: "lymphotactin receptor" EXACT [] synonym: "SCM1 receptor" EXACT [] synonym: "XC chemokine receptor 1" EXACT [] synonym: "XCR1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:75 is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001221 name: endothelin-1 receptor namespace: protein def: "An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3." [PMID:12037137, PRO:WCB] comment: Category=gene. synonym: "EDNRA" EXACT PRO-short-label [PRO:DNx] synonym: "endothelin A receptor" EXACT [] synonym: "endothelin receptor A" EXACT [] synonym: "endothelin receptor type A" EXACT [] synonym: "ET-A" BROAD [PRO:DNx] synonym: "ET-AR" EXACT [] synonym: "ETA" RELATED Gene-based [] synonym: "ETA-R" EXACT [] synonym: "ETRA" RELATED Gene-based [] synonym: "Gpcr10" RELATED Gene-based [] xref: IUPHARobj:219 is_a: PR:000001133 ! endothelin receptor [Term] id: PR:000001223 name: gastrin-releasing peptide receptor namespace: protein def: "A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide." [PRO:WCB] comment: Category=gene. synonym: "GRP-preferring bombesin receptor" EXACT [] synonym: "GRP-R" EXACT [] synonym: "GRPR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:39 is_a: PR:000001122 ! bombesin receptor [Term] id: PR:000001225 name: growth hormone secretagogue receptor namespace: protein def: "A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands." [PRO:WCB, Wikipedia:Growth_hormone_secretagogue_receptor] comment: Category=gene. synonym: "GH-releasing peptide receptor" EXACT [] synonym: "ghrelin receptor" EXACT [] synonym: "GHRP" EXACT [] synonym: "GHS-R" EXACT [] synonym: "GHSR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:246 is_a: PR:000001134 ! growth hormone secretagogue/motilin receptor [Term] id: PR:000001240 name: motilin receptor namespace: protein def: "A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle." [PRO:WCB, Wikipedia:Motilin_receptor] comment: Category=gene. synonym: "G-protein coupled receptor 38" EXACT [] synonym: "GPR38" RELATED Gene-based [] synonym: "MLNR" EXACT PRO-short-label [PRO:DNx] synonym: "MTLR" RELATED Gene-based [] synonym: "MTLR1" RELATED Gene-based [] xref: IUPHARobj:297 is_a: PR:000001134 ! growth hormone secretagogue/motilin receptor [Term] id: PR:000001245 name: rhodopsin namespace: protein def: "An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "OPN2" RELATED Gene-based [] synonym: "opsin-2" EXACT [] synonym: "RHO" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2963 is_a: PR:000001119 ! animal opsin [Term] id: PR:000001255 name: C-C chemokine receptor type 3 namespace: protein def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." [PMID:12037138, PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "C-C CKR-3" EXACT [] synonym: "CC-CKR-3" EXACT [] synonym: "CCR-3" EXACT [] synonym: "CCR3" EXACT PRO-short-label [PRO:DNx] synonym: "CD193" EXACT [] synonym: "chemokine receptor CCR3" EXACT [] synonym: "CKR3" EXACT [] synonym: "Cmkbr1l2" RELATED Gene-based [] synonym: "CMKBR3" RELATED Gene-based [] synonym: "eosinophil eotaxin receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT [] synonym: "MIP-1 alpha RL2" EXACT [] xref: IUPHARobj:60 is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001315 name: frizzled-like G-protein coupled receptor namespace: protein def: "A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts." [InterPro:IPR015526, PRO:DAN, PRO:WCB] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "class F G-protein coupled receptor" EXACT [IUPHARfam:25] synonym: "fam:frizzled" EXACT PRO-short-label [PRO:DAN] xref: IUPHAR:GPCRListForward?class=frizzled xref: IUPHARfam:25 xref: PIRSF:PIRSF006696 is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001317 name: interleukin-7 namespace: protein def: "A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "IL-7" EXACT [] synonym: "IL7" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF001942 is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin namespace: protein def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF002504 is_a: PR:000000001 ! protein [Term] id: PR:000001335 name: class 2 cytokine, IL-10 type namespace: protein def: "A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain." [PRO:CNA] comment: Category=family. xref: PIRSF:PIRSF003542 is_a: PR:000000001 ! protein [Term] id: PR:000001348 name: erythrocyte membrane protein Rh namespace: protein def: "A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens." [PMID:7888828, PMID:9433124] comment: Category=family. xref: PIRSF:PIRSF017968 is_a: PR:000000001 ! protein [Term] id: PR:000001349 name: fibroblast growth factor receptor namespace: protein def: "A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution." [PMID:15475116] comment: Category=family. xref: PIRSF:PIRSF000628 is_a: PR:000000001 ! protein [Term] id: PR:000001353 name: granulocyte colony-stimulating factor receptor namespace: protein def: "A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains." [PMID:1723014, PRO:CNA] comment: Category=gene. synonym: "CD114" EXACT [] synonym: "CSF3R" EXACT PRO-short-label [PRO:DNx] synonym: "Csfgr" RELATED Gene-based [] synonym: "G-CSF receptor" EXACT [] synonym: "G-CSF-R" EXACT [] synonym: "GCSFR" RELATED Gene-based [] xref: IUPHARobj:1719 is_a: PR:000000001 ! protein [Term] id: PR:000001357 name: intercellular adhesion molecule 1/3 namespace: protein def: "A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam." [PRO:WCB] comment: Category=family. synonym: "ICAM" RELATED [] xref: PIRSF:PIRSF002510 is_a: PR:000000001 ! protein [Term] id: PR:000001366 name: interleukin-11 namespace: protein def: "A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "adipogenesis inhibitory factor" EXACT [] synonym: "AGIF" EXACT [] synonym: "IL-11" EXACT [] synonym: "IL11" EXACT PRO-short-label [PRO:DNx] synonym: "oprelvekin" EXACT [] xref: PIRSF:PIRSF001944 is_a: PR:000000001 ! protein [Term] id: PR:000001368 name: interleukin-12 subunit alpha namespace: protein def: "A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35." [PRO:CNA] comment: Category=gene. synonym: "CLMF p35" EXACT [] synonym: "cytotoxic lymphocyte maturation factor 35 kDa subunit" EXACT [] synonym: "IL-12 subunit p35" EXACT [] synonym: "IL-12A" EXACT [] synonym: "IL12A" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell stimulatory factor chain 1" EXACT [] synonym: "NKSF1" RELATED Gene-based [] xref: PIRSF:PIRSF037684 is_a: PR:000000001 ! protein [Term] id: PR:000001369 name: interleukin-12 subunit beta namespace: protein def: "A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23." [PRO:CNA] comment: Category=gene. synonym: "CLMF p40" EXACT [] synonym: "cytotoxic lymphocyte maturation factor 40 kDa subunit" EXACT [] synonym: "IL-12 subunit p40" EXACT [] synonym: "IL-12B" EXACT [] synonym: "IL12B" EXACT PRO-short-label [PRO:DNx] synonym: "NK cell stimulatory factor chain 2" EXACT [] synonym: "NKSF2" RELATED Gene-based [] xref: PIRSF:PIRSF038007 is_a: PR:000000001 ! protein [Term] id: PR:000001370 name: interleukin-13 namespace: protein def: "A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related." [PRO:CNA] comment: Category=gene. synonym: "IL-13" EXACT [] synonym: "IL13" EXACT PRO-short-label [PRO:DNx] synonym: "NC30" RELATED Gene-based [] synonym: "T-cell activation protein P600" EXACT [] xref: PIRSF:PIRSF001945 is_a: PR:000000001 ! protein [Term] id: PR:000001373 name: interleukin-15 namespace: protein def: "A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-15" EXACT [] synonym: "IL15" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001374 name: pro-interleukin-16 namespace: protein def: "A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL16" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000001376 name: interleukin-18 namespace: protein def: "A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "iboctadekin" EXACT [] synonym: "IFN-gamma-inducing factor" EXACT [] synonym: "IGIF" RELATED Gene-based [] synonym: "IL-1 gamma" EXACT [] synonym: "IL-18" EXACT [] synonym: "IL18" EXACT PRO-short-label [PRO:DNx] synonym: "IL1F4" RELATED Gene-based [] synonym: "interferon gamma-inducing factor" EXACT [] synonym: "interleukin-1 gamma" EXACT [] xref: PIRSF:PIRSF015162 is_a: PR:000000001 ! protein [Term] id: PR:000001379 name: interleukin-2 namespace: protein def: "A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity." [PMID:18062768, PRO:CNA] comment: Category=gene. synonym: "aldesleukin" EXACT [] synonym: "IL-2" EXACT [] synonym: "IL2" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell growth factor" EXACT [] synonym: "TCGF" EXACT [] xref: PIRSF:PIRSF001938 is_a: PR:000000001 ! protein [Term] id: PR:000001382 name: interleukin-21 namespace: protein def: "A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-21" EXACT [] synonym: "IL21" EXACT PRO-short-label [PRO:DNx] synonym: "Za11" EXACT [] xref: PIRSF:PIRSF038753 is_a: PR:000000001 ! protein [Term] id: PR:000001383 name: interleukin-22 namespace: protein def: "A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "cytokine Zcyto18" EXACT [] synonym: "IL-10-related T-cell-derived-inducible factor" EXACT [] synonym: "IL-22" EXACT [] synonym: "IL-22a" EXACT [] synonym: "IL-TIF" EXACT [] synonym: "IL-TIF alpha" EXACT [] synonym: "IL22" EXACT PRO-short-label [PRO:DNx] synonym: "Il22a" RELATED [] synonym: "ILTIF" RELATED Gene-based [] synonym: "Iltifa" RELATED [] synonym: "interleukin-22a" EXACT [] synonym: "UNQ3099/PRO10096" RELATED Gene-based [] synonym: "ZCYTO18" RELATED Gene-based [] xref: PIRSF:PIRSF037726 is_a: PR:000000001 ! protein [Term] id: PR:000001387 name: interleukin-3 namespace: protein def: "A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "Csfmu" RELATED Gene-based [] synonym: "hematopoietic growth factor" EXACT [] synonym: "IL-3" EXACT [] synonym: "IL3" EXACT PRO-short-label [PRO:DNx] synonym: "mast cell growth factor" RELATED [] synonym: "MCGF" EXACT [] synonym: "multipotential colony-stimulating factor" EXACT [] synonym: "P-cell-stimulating factor" EXACT [] xref: PIRSF:PIRSF001939 is_a: PR:000000001 ! protein [Term] id: PR:000001389 name: interleukin-33 namespace: protein def: "A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "C9orf26" RELATED Gene-based [] synonym: "IL-1F11" EXACT [] synonym: "IL-33" EXACT [] synonym: "IL1F11" RELATED Gene-based [] synonym: "IL33" EXACT PRO-short-label [PRO:DNx] synonym: "interleukin-1 family member 11" EXACT [] synonym: "NF-HEV" EXACT [] synonym: "NFHEV" RELATED Gene-based [] synonym: "nuclear factor from high endothelial venules" EXACT [] xref: PIRSF:PIRSF038478 is_a: PR:000000001 ! protein [Term] id: PR:000001391 name: interleukin-4 namespace: protein def: "A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "B-cell growth factor 1" EXACT [] synonym: "B-cell IgG differentiation factor" EXACT [] synonym: "B-cell stimulatory factor 1" EXACT [] synonym: "binetrakin" EXACT [] synonym: "BSF-1" EXACT [] synonym: "IGG1 induction factor" EXACT [] synonym: "IL-4" EXACT [] synonym: "IL4" EXACT PRO-short-label [PRO:DNx] synonym: "lymphocyte stimulatory factor 1" EXACT [] synonym: "pitrakinra" EXACT [] xref: PIRSF:PIRSF001941 is_a: PR:000000001 ! protein [Term] id: PR:000001392 name: interleukin-5 namespace: protein def: "A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "B-cell differentiation factor I" EXACT [] synonym: "B-cell growth factor II" EXACT [] synonym: "BCGF-II" EXACT [] synonym: "cytotoxic T-lymphocyte inducer" EXACT [] synonym: "eosinophil differentiation factor" EXACT [] synonym: "IL-5" EXACT [] synonym: "IL5" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell replacing factor" EXACT [] synonym: "TRF" EXACT [] xref: PIRSF:PIRSF001940 is_a: PR:000000001 ! protein [Term] id: PR:000001393 name: interleukin-6 namespace: protein def: "A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "B-cell hybridoma growth factor" EXACT [] synonym: "B-cell stimulatory factor 2" EXACT [] synonym: "BSF-2" EXACT [] synonym: "CDF" EXACT [] synonym: "CTL differentiation factor" EXACT [] synonym: "hybridoma growth factor" EXACT [] synonym: "IFN-beta-2" EXACT [] synonym: "IFNB2" RELATED Gene-based [] synonym: "IL-6" EXACT [] synonym: "IL6" EXACT PRO-short-label [PRO:DNx] synonym: "interferon beta-2" EXACT [] synonym: "interleukin HP-1" EXACT [] xref: PIRSF:PIRSF001935 is_a: PR:000000001 ! protein [Term] id: PR:000001395 name: interleukin-8 namespace: protein def: "A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "C-X-C motif chemokine 8" EXACT [] synonym: "CXCL8" EXACT PRO-short-label [PRO:DNx] synonym: "emoctakin" EXACT [] synonym: "GCP-1" RELATED [] synonym: "granulocyte chemotactic protein 1" EXACT [] synonym: "IL-8" EXACT [] synonym: "IL8" RELATED Gene-based [] synonym: "MDNCF" EXACT [] synonym: "MONAP" EXACT [] synonym: "monocyte-derived neutrophil chemotactic factor" EXACT [] synonym: "monocyte-derived neutrophil-activating peptide" EXACT [] synonym: "NAP-1" EXACT [] synonym: "neutrophil-activating protein 1" EXACT [] synonym: "protein 3-10C" EXACT [] synonym: "T-cell chemotactic factor" EXACT [] xref: PIRSF:PIRSF500564 is_a: PR:000000001 ! protein [Term] id: PR:000001396 name: interleukin-9 namespace: protein def: "A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "cytokine P40" EXACT [] synonym: "IL-9" EXACT [] synonym: "IL9" EXACT PRO-short-label [PRO:DNx] synonym: "T-cell growth factor P40" EXACT [] xref: PIRSF:PIRSF001943 is_a: PR:000000001 ! protein [Term] id: PR:000001397 name: interleukin-9 receptor namespace: protein def: "A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. synonym: "CD129" EXACT [] synonym: "IL-9 receptor" EXACT [] synonym: "IL-9R" EXACT [] synonym: "IL9R" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1699 xref: PIRSF:PIRSF018548 is_a: PR:000000001 ! protein [Term] id: PR:000001422 name: histamine H1 receptor namespace: protein def: "A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Note: The preferred ligand is histamine. This receptor mediates smooth muscle contraction, NO formation, increased vascular permeability, and other diverse effects. [PMID:9311023] synonym: "Bphs" RELATED Gene-based [] synonym: "H1 histamine receptor" EXACT [] synonym: "H1R" EXACT [] synonym: "HH1R" EXACT [] synonym: "HRH1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:262 xref: PIRSF:PIRSF038644 is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001423 name: histamine H2 receptor namespace: protein def: "A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects." [PMID:9311023, PRO:WCB] comment: Category=gene. synonym: "gastric receptor I" EXACT [] synonym: "H2 histamine receptor" EXACT [] synonym: "H2R" EXACT [] synonym: "HH2R" EXACT [] synonym: "HRH2" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:263 xref: PIRSF:PIRSF038634 is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001426 name: KiSS-1 receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein." [PRO:WCB, UniProtKB:Q15726] comment: Category=gene. synonym: "AXOR12" RELATED Gene-based [] synonym: "G-protein coupled receptor 54" EXACT [] synonym: "G-protein coupled receptor OT7T175" EXACT [] synonym: "GPR54" RELATED Gene-based [] synonym: "hypogonadotropin-1" EXACT [] synonym: "KiSS-1R" EXACT [] synonym: "KISS1R" EXACT PRO-short-label [PRO:DNx] synonym: "kisspeptins receptor" EXACT [] synonym: "metastin receptor" EXACT [] synonym: "OT7T175" EXACT [] xref: IUPHARobj:266 xref: PIRSF:PIRSF038571 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001431 name: N-formyl peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides." [InterPro:IPR000826, PRO:DAN, PRO:WCB, PRO:XQ] comment: Category=family. synonym: "formylpeptide receptor" EXACT [IUPHARfam:23] xref: IUPHARfam:23 xref: PIRSF:PIRSF038561 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001439 name: adenosine receptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:3 xref: PIRSF:PIRSF005692 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001442 name: blood group Rh(D) polypeptide namespace: protein def: "An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "blood group RhD polypeptide" EXACT [] synonym: "CD240D" EXACT [] synonym: "Rh polypeptide 2" EXACT [] synonym: "RHD" EXACT PRO-short-label [PRO:DNx] synonym: "rhesus D antigen" EXACT [] synonym: "RhPII" EXACT [] synonym: "RHXIII" EXACT [] is_a: PR:000001348 ! erythrocyte membrane protein Rh [Term] id: PR:000001449 name: fibroblast growth factor receptor 2 namespace: protein def: "A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "BEK" RELATED Gene-based [] synonym: "CD332" EXACT [] synonym: "Ect1" RELATED Gene-based [] synonym: "FGFR-2" EXACT [] synonym: "FGFR2" EXACT PRO-short-label [PRO:DNx] synonym: "K-sam" EXACT [] synonym: "keratinocyte growth factor receptor" EXACT [] synonym: "KGFR" RELATED Gene-based [] synonym: "KSAM" RELATED Gene-based [] xref: IUPHARobj:1809 is_a: PR:000001349 ! fibroblast growth factor receptor [Term] id: PR:000001457 name: galanin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin." [PMID:10689365, PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:27 xref: PIRSF:PIRSF038570 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001463 name: glycoprotein hormone receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin)." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:30 xref: PIRSF:PIRSF002408 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001464 name: gonadotropin-releasing hormone receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:31 xref: PIRSF:PIRSF038576 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001468 name: intercellular adhesion molecule 3 namespace: protein def: "An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. This gene has been found in primates and Bos taurus, but not in mouse and rat. synonym: "CD50" EXACT [] synonym: "CDw50" EXACT [] synonym: "ICAM-3" EXACT [] synonym: "ICAM-R" EXACT [] synonym: "ICAM3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001357 ! intercellular adhesion molecule 1/3 [Term] id: PR:000001471 name: interleukin-10 namespace: protein def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=gene. Note: Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds. synonym: "CSIF" EXACT [] synonym: "cytokine synthesis inhibitory factor" EXACT [] synonym: "IL-10" EXACT [] synonym: "IL10" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001472 name: interleukin-19 namespace: protein def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-19" EXACT [] synonym: "IL19" EXACT PRO-short-label [PRO:DNx] synonym: "melanoma differentiation-associated protein-like protein" EXACT [] synonym: "NG.1" EXACT [] synonym: "ZMDA1" RELATED Gene-based [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001473 name: interleukin-20 namespace: protein def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "cytokine Zcyto10" EXACT [] synonym: "IL-20" EXACT [] synonym: "IL20" EXACT PRO-short-label [PRO:DNx] synonym: "UNQ852/PRO1801" RELATED Gene-based [] synonym: "ZCYTO10" RELATED Gene-based [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001474 name: interleukin-24 namespace: protein def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "IL-24" EXACT [] synonym: "IL-4-induced secreted protein" EXACT [] synonym: "IL24" EXACT PRO-short-label [PRO:DNx] synonym: "MDA-7" EXACT [] synonym: "MDA7" RELATED Gene-based [] synonym: "melanoma differentiation-associated gene 7 protein" EXACT [] synonym: "ST16" RELATED Gene-based [] synonym: "suppression of tumorigenicity 16 protein" EXACT [] synonym: "Th2-specific cytokine FISP" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001475 name: interleukin-26 namespace: protein def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "AK155" RELATED Gene-based [] synonym: "IL-26" EXACT [] synonym: "IL26" EXACT PRO-short-label [PRO:DNx] synonym: "protein AK155" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001488 name: muscarinic acetylcholine receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:WCB, PRO:XQ, Wikipedia:Muscarinic_acetylcholine_receptor] comment: Category=family. Note: The active form binds the neurotransmitter acetylcholine. They are more sensitive to muscarine than to nicotine. xref: IUPHARfam:2 xref: PIRSF:PIRSF038548 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001489 name: neuromedin-U receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:WCB] comment: Category=family. Note: The active form binds the neuropeptide neuromedin-U. synonym: "fam:NMU_R" EXACT PRO-short-label [PRO:DAN] synonym: "neuromedin U receptor" EXACT [IUPHARfam:42] xref: IUPHARfam:42 xref: PIRSF:PIRSF038640 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001497 name: opioid receptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:WCB, PRO:XQ] comment: Category=family. Note: The active form binds opioids. xref: IUPHARfam:50 xref: PIRSF:PIRSF038567 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001498 name: pyroglutamylated RF-amide peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof." [PRO:WCB, UniProtKB:Q96P65] comment: Category=gene. Note: This receptor is expressed at high levels in brain and retina and at moderate levels in the heart, kidney, testis and thyroid. synonym: "AQ27" EXACT [] synonym: "G-protein coupled receptor 103" EXACT [] synonym: "GPR103" RELATED Gene-based [] synonym: "orexigenic neuropeptide QRFP receptor" EXACT [] synonym: "QRFPR" EXACT PRO-short-label [PRO:DNx] synonym: "SP9155" EXACT [] xref: IUPHARobj:333 xref: PIRSF:PIRSF038648 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001499 name: orexin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:WCB, PRO:XQ] comment: Category=family. Note: The active form binds the neuropeptide hormone orexin (hypocretin). synonym: "hypocretin receptor" EXACT [] xref: IUPHARfam:51 xref: PIRSF:PIRSF038624 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001546 name: prolactin-releasing peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "G-protein coupled receptor 10" EXACT [] synonym: "Gm339" RELATED Gene-based [] synonym: "GPR10" RELATED Gene-based [] synonym: "GR3" RELATED Gene-based [] synonym: "PRLHR" EXACT PRO-short-label [PRO:DNx] synonym: "PrRP receptor" EXACT [] synonym: "PrRPR" EXACT [] xref: IUPHARobj:337 xref: PIRSF:PIRSF038611 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001548 name: prostaglandin E2 receptor EP4 subtype namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors." [PRO:WCB] comment: Category=gene. synonym: "PGE receptor EP4 subtype" EXACT [] synonym: "PGE2 receptor EP4 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP4" EXACT [] synonym: "prostanoid EP4 receptor" EXACT [] synonym: "PTGER2" RELATED Gene-based [] synonym: "PTGER4" EXACT PRO-short-label [PRO:DNx] synonym: "Ptgerep4" RELATED Gene-based [] xref: IUPHARobj:343 xref: PIRSF:PIRSF038586 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001549 name: prostanoid receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes)." [PMID:7938166, PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:58 xref: PIRSF:PIRSF001962 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001550 name: proteinase-activated receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PRO:WCB, PRO:XQ] comment: Category=family. synonym: "fam:PAR" EXACT PRO-short-label [PRO:DAN] xref: IUPHARfam:59 xref: PIRSF:PIRSF037996 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001555 name: somatostatin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin." [PRO:WCB, PRO:XQ] comment: Category=family. xref: IUPHARfam:61 xref: PIRSF:PIRSF038568 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001557 name: thyrotropin-releasing hormone receptor type 1 namespace: protein def: "A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone." [PRO:WCB] comment: Category=gene. synonym: "thyroliberin receptor" EXACT [] synonym: "TRH-R" BROAD [PRO:DNx] synonym: "TRH-R1" EXACT [] synonym: "TRHR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:363 xref: PIRSF:PIRSF038645 is_a: PR:000050029 ! thyrotropin-releasing hormone receptor [Term] id: PR:000001562 name: vasopressin/oxytocin receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides." [PRO:WCB, PRO:XQ, Wikipedia:Vasopressin, Wikipedia:Vasopressin_receptor] comment: Category=family. synonym: "name: vasopressin and oxytocin receptor" EXACT [IUPHARfam:66] xref: IUPHARfam:66 xref: PIRSF:PIRSF001841 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001564 name: histamine H3 receptor namespace: protein def: "A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects." [PMID:9311023, PRO:WCB] comment: Category=gene. synonym: "G-protein coupled receptor 97" RELATED [] synonym: "GPCR97" RELATED Gene-based [] synonym: "H3 histamine receptor" EXACT [] synonym: "H3R" EXACT [] synonym: "HH3R" EXACT [] synonym: "HRH3" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:264 is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001565 name: H4 histamine receptor namespace: protein def: "A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node." [PRO:WCB, UniProtKB:Q9H3N8] comment: Category=gene. synonym: "AXOR35" EXACT [] synonym: "G-protein coupled receptor 105" RELATED [] synonym: "GPCR105" RELATED Gene-based [] synonym: "GPRv53" EXACT [] synonym: "H4R" EXACT [] synonym: "HH4R" EXACT [] synonym: "HRH4" EXACT PRO-short-label [PRO:DNx] synonym: "Pfi-013" EXACT [] synonym: "SP9144" EXACT [] xref: IUPHARobj:265 is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001579 name: delta-type opioid receptor namespace: protein def: "An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins." [PRO:WCB, Wikipedia:delta_Opioid_receptor] comment: Category=gene. synonym: "D-OR-1" EXACT [] synonym: "delta-opioid receptor" EXACT [] synonym: "DOR-1" EXACT [] synonym: "K56" EXACT [] synonym: "MSL-2" RELATED [] synonym: "OPRD" RELATED Gene-based [] synonym: "OPRD1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:317 is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001590 name: kappa-type opioid receptor namespace: protein def: "An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin." [PRO:WCB, Wikipedia:kappa_Opioid_receptor] comment: Category=gene. synonym: "K-OR-1" EXACT [] synonym: "kappa-opioid receptor" EXACT [] synonym: "KOR-1" EXACT [] synonym: "MSL-1" RELATED [] synonym: "OPRK" RELATED Gene-based [] synonym: "OPRK1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:318 is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001596 name: lutropin-choriogonadotropic hormone receptor namespace: protein def: "A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone)." [PRO:WCB] comment: Category=gene. synonym: "LCGR" RELATED Gene-based [] synonym: "LGR2" RELATED Gene-based [] synonym: "LH/CG-R" EXACT [] synonym: "LHCGR" EXACT PRO-short-label [PRO:DNx] synonym: "LHR" EXACT [] synonym: "LHRHR" RELATED Gene-based [] synonym: "LSH-R" EXACT [] synonym: "luteinizing hormone receptor" EXACT [] synonym: "lutropin/choriogonadotropin receptor" EXACT [] xref: IUPHARobj:254 is_a: PR:000001463 ! glycoprotein hormone receptor [Term] id: PR:000001612 name: mu-type opioid receptor namespace: protein def: "An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins." [PRO:WCB, Wikipedia:mu_Opioid_receptor] comment: Category=gene. synonym: "M-OR-1" EXACT [] synonym: "MOP" EXACT [] synonym: "Mor" RELATED Gene-based [] synonym: "MOR-1" EXACT [] synonym: "MOR1" RELATED Gene-based [] synonym: "mu opiate receptor" EXACT [] synonym: "mu opioid receptor" EXACT [] synonym: "mu-opioid receptor" EXACT [] synonym: "Oprm" RELATED Gene-based [] synonym: "OPRM1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:319 is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001631 name: nociceptin receptor namespace: protein def: "An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin." [PRO:WCB] comment: Category=gene. synonym: "K3 opiate receptor" EXACT [] synonym: "kappa-type 3 opioid receptor" EXACT [] synonym: "KOR-3" EXACT [] synonym: "OOR" RELATED Gene-based [] synonym: "Oprl" RELATED Gene-based [] synonym: "OPRL1" EXACT PRO-short-label [PRO:DNx] synonym: "ORGC" EXACT [] synonym: "ORL1" RELATED Gene-based [] synonym: "orphanin FQ receptor" EXACT [] xref: IUPHARobj:320 is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001635 name: oxytocin receptor namespace: protein def: "A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin." [PRO:WCB] comment: Category=gene. synonym: "OT-R" EXACT [] synonym: "OXTR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:369 is_a: PR:000001562 ! vasopressin/oxytocin receptor [Term] id: PR:000001655 name: prostacyclin receptor namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGI receptor" EXACT [] synonym: "PGI2 receptor" EXACT [] synonym: "PRIPR" RELATED Gene-based [] synonym: "prostaglandin I2 receptor" EXACT [] synonym: "prostanoid IP receptor" EXACT [] synonym: "PTGIR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:345 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001656 name: prostaglandin D2 receptor namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGD receptor" EXACT [] synonym: "PGD2 receptor" EXACT [] synonym: "prostanoid DP receptor" EXACT [] synonym: "PTGDR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:338 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001657 name: prostaglandin E2 receptor EP1 subtype namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGE receptor EP1 subtype" EXACT [] synonym: "PGE2 receptor EP1 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP1" EXACT [] synonym: "prostanoid EP1 receptor" EXACT [] synonym: "PTGER1" EXACT PRO-short-label [PRO:DNx] synonym: "Ptgerep1" RELATED Gene-based [] xref: IUPHARobj:340 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001658 name: prostaglandin E2 receptor EP2 subtype namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGE receptor EP2 subtype" EXACT [] synonym: "PGE2 receptor EP2 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP2" EXACT [] synonym: "prostanoid EP2 receptor" EXACT [] synonym: "PTGER2" EXACT PRO-short-label [PRO:DNx] synonym: "Ptgerep2" RELATED Gene-based [] xref: IUPHARobj:341 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001659 name: prostaglandin E2 receptor EP3 subtype namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGE receptor EP3 subtype" EXACT [] synonym: "PGE2 receptor EP3 subtype" EXACT [] synonym: "PGE2-R" EXACT [] synonym: "prostaglandin E2 receptor EP3" EXACT [] synonym: "prostanoid EP3 receptor" EXACT [] synonym: "PTGER3" EXACT PRO-short-label [PRO:DNx] synonym: "Ptgerep3" RELATED Gene-based [] xref: IUPHARobj:342 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001660 name: prostaglandin F2-alpha receptor namespace: protein def: "A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "PGF receptor" EXACT [] synonym: "PGF2-alpha receptor" EXACT [] synonym: "prostanoid FP receptor" EXACT [] synonym: "PTGFR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:344 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001661 name: proteinase-activated receptor 1 namespace: protein def: "A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB] comment: Category=gene. synonym: "CF2R" RELATED Gene-based [] synonym: "coagulation factor II receptor" EXACT [] synonym: "F2R" EXACT PRO-short-label [PRO:DNx] synonym: "PAR-1" EXACT [] synonym: "PAR1" RELATED Gene-based [] synonym: "thrombin receptor" EXACT [] synonym: "TR" RELATED Gene-based [] xref: IUPHARobj:347 is_a: PR:000001550 ! proteinase-activated receptor [Term] id: PR:000001676 name: thromboxane A2 receptor namespace: protein def: "A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle." [PMID:7938166, PRO:WCB] comment: Category=gene. synonym: "prostanoid TP receptor" EXACT [] synonym: "TBXA2R" EXACT PRO-short-label [PRO:DNx] synonym: "TXA2-R" EXACT [] xref: IUPHARobj:346 is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001753 name: transcription factor NF-kappa-B subunit namespace: protein def: "A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region." [PRO:JAN] comment: Category=family. synonym: "transcription factor NF-kappa-B" RELATED [] xref: PIRSF:PIRSF036310 is_a: PR:000000001 ! protein [Term] id: PR:000001808 name: C/C-C motif small inducible chemokine namespace: protein def: "A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain." [PRO:WCB] comment: Category=family. synonym: "fam:C/C-C chemokine" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF001950 is_a: PR:000000001 ! protein [Term] id: PR:000001810 name: CSF-1/PDGF receptor-type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF000615 is_a: PR:000000001 ! protein [Term] id: PR:000001812 name: EGF receptor type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF000619 is_a: PR:000000001 ! protein [Term] id: PR:000001816 name: HGF/MSP receptor type tyrosine-protein kinase namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF000617 is_a: PR:000000001 ! protein [Term] id: PR:000001876 name: leukemia inhibitory factor receptor namespace: protein def: "A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CD118" EXACT [] synonym: "D-factor/LIF receptor" EXACT [] synonym: "LIF receptor" EXACT [] synonym: "LIF-R" EXACT [] synonym: "LIFR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1713 is_a: PR:000000001 ! protein [Term] id: PR:000001887 name: melanotransferrin namespace: protein def: "A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CD228" EXACT [] synonym: "MAP97" RELATED Gene-based [] synonym: "melanoma-associated antigen p97" EXACT [] synonym: "MELTF" EXACT PRO-short-label [PRO:DNx] synonym: "membrane-bound transferrin-like protein p97" EXACT [] synonym: "MFI2" RELATED Gene-based [] synonym: "MTf" EXACT [] xref: PIRSF:PIRSF500685 is_a: PR:000000001 ! protein [Term] id: PR:000001902 name: nuclear receptor ROR-gamma namespace: protein def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "NR1F3" RELATED Gene-based [] synonym: "nuclear receptor RZR-gamma" EXACT [] synonym: "nuclear receptor subfamily 1 group F member 3" EXACT [] synonym: "RAR-related orphan receptor C" EXACT [] synonym: "retinoid-related orphan receptor-gamma" EXACT [] synonym: "RORC" EXACT PRO-short-label [PRO:DNx] synonym: "RORG" RELATED Gene-based [] synonym: "RZRG" RELATED Gene-based [] synonym: "Thor" RELATED Gene-based [] synonym: "thymus orphan receptor" EXACT [] synonym: "TOR" EXACT [] xref: IUPHARobj:600 is_a: PR:000000001 ! protein [Term] id: PR:000001926 name: semaphorin namespace: protein def: "A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF005526 is_a: PR:000000001 ! protein [Term] id: PR:000001946 name: tumor necrosis factor ligand superfamily member 10/11 namespace: protein def: "A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038013 is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor namespace: protein def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF038502 is_a: PR:000000001 ! protein [Term] id: PR:000001991 name: C-C motif chemokine 19 namespace: protein def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "beta chemokine exodus-3" EXACT [] synonym: "CCL19" EXACT PRO-short-label [PRO:DNx] synonym: "CK beta-11" EXACT [] synonym: "EBI1 ligand chemokine" EXACT [] synonym: "ELC" RELATED Gene-based [] synonym: "epstein-Barr virus-induced molecule 1 ligand chemokine" EXACT [] synonym: "macrophage inflammatory protein 3 beta" EXACT [] synonym: "MIP-3-beta" EXACT [] synonym: "MIP3B" RELATED Gene-based [] synonym: "SCYA19" RELATED Gene-based [] synonym: "small-inducible cytokine A19" EXACT [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000001993 name: C-C motif chemokine 21 namespace: protein def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Three genes code for CCL21 in mouse. Ccl21b and Ccl21c genes encode identical proteins while the protein encoded by Ccl21a differs at only one position. synonym: "6Ckine" BROAD [PRO:DNx] synonym: "beta chemokine exodus-2" EXACT [] synonym: "CCL21" EXACT PRO-short-label [PRO:DNx] synonym: "Ccl21b" RELATED [] synonym: "Ccl21c" RELATED [] synonym: "SCYA21" RELATED Gene-based [] synonym: "Scya21b" RELATED [] synonym: "Scya21c" RELATED [] synonym: "secondary lymphoid-tissue chemokine" EXACT [] synonym: "SLC" EXACT [] synonym: "small-inducible cytokine A21" EXACT [] synonym: "small-inducible cytokine A21a" BROAD [PRO:DNx] synonym: "small-inducible cytokine A21b" BROAD [PRO:DNx] synonym: "small-inducible cytokine A21c" BROAD [PRO:DNx] synonym: "TCA4" BROAD [PRO:DNx] synonym: "thymus-derived chemotactic agent 4" BROAD [PRO:DNx] synonym: "UNQ784/PRO1600" RELATED Gene-based [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002038 name: eotaxin-like cytokine namespace: protein def: "A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF500572 is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002065 name: mast/stem cell growth factor receptor namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD117" EXACT [] synonym: "KIT" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Kit" EXACT [] synonym: "SCFR" RELATED Gene-based [] synonym: "Sl" RELATED Gene-based [] synonym: "tyrosine-protein kinase Kit" EXACT [] xref: IUPHARobj:1805 xref: PIRSF:PIRSF500951 is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002094 name: C-C motif chemokine 5 namespace: protein def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CCL5" EXACT PRO-short-label [PRO:DNx] synonym: "D17S136E" RELATED Gene-based [] synonym: "EoCP" EXACT [] synonym: "eosinophil chemotactic cytokine" RELATED [] synonym: "RANTES" EXACT [] synonym: "SCYA5" RELATED Gene-based [] synonym: "SIS-delta" EXACT [] synonym: "small inducible cytokine A5" EXACT [] synonym: "small-inducible cytokine A5" EXACT [] synonym: "T cell-specific protein P228" EXACT [] synonym: "T-cell-specific protein RANTES" EXACT [] synonym: "TCP228" EXACT [] xref: PIRSF:PIRSF500570 is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002106 name: tumor necrosis factor ligand superfamily member 10 namespace: protein def: "A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "apo-2 ligand" EXACT [] synonym: "apo-2L" EXACT [] synonym: "APO2L" RELATED Gene-based [] synonym: "CD253" EXACT [] synonym: "protein TRAIL" EXACT [] synonym: "TNF-related apoptosis-inducing ligand" EXACT [] synonym: "TNFSF10" EXACT PRO-short-label [PRO:DNx] synonym: "TRAIL" RELATED Gene-based [] is_a: PR:000001946 ! tumor necrosis factor ligand superfamily member 10/11 [Term] id: PR:000002107 name: tumor necrosis factor ligand superfamily member 11 namespace: protein def: "A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CD254" EXACT [] synonym: "ODF" EXACT [] synonym: "OPGL" RELATED Gene-based [] synonym: "osteoclast differentiation factor" EXACT [] synonym: "osteoprotegerin ligand" EXACT [] synonym: "RANKL" RELATED Gene-based [] synonym: "receptor activator of nuclear factor kappa-B ligand" EXACT [] synonym: "TNF-related activation-induced cytokine" EXACT [] synonym: "TNFSF11" EXACT PRO-short-label [PRO:DNx] synonym: "TRANCE" RELATED Gene-based [] is_a: PR:000001946 ! tumor necrosis factor ligand superfamily member 10/11 [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED Gene-based [] synonym: "KDR" EXACT PRO-short-label [PRO:DNx] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] synonym: "VEGFR2" RELATED Gene-based [] xref: IUPHARobj:1813 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002122 name: C-C motif chemokine 2 namespace: protein def: "An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CCL2" EXACT PRO-short-label [PRO:DNx] synonym: "HC11" EXACT [] synonym: "Je" RELATED Gene-based [] synonym: "MCAF" EXACT [] synonym: "MCP-1" BROAD [PRO:DAN] synonym: "MCP1" RELATED Gene-based [] synonym: "monocyte chemoattractant protein 1" EXACT [] synonym: "monocyte chemotactic and activating factor" EXACT [] synonym: "monocyte chemotactic protein 1" EXACT [] synonym: "monocyte secretory protein JE" EXACT [] synonym: "platelet-derived growth factor-inducible protein JE" EXACT [] synonym: "SCYA2" RELATED Gene-based [] synonym: "small-inducible cytokine A2" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000002125 name: C-C motif chemokine 7 namespace: protein def: "An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CCL7" EXACT PRO-short-label [PRO:DNx] synonym: "Fic" RELATED Gene-based [] synonym: "intercrine/chemokine MARC" EXACT [] synonym: "MCP-3" EXACT [] synonym: "MCP3" RELATED Gene-based [] synonym: "monocyte chemoattractant protein 3" EXACT [] synonym: "monocyte chemotactic protein 3" EXACT [] synonym: "NC28" EXACT [] synonym: "protein FIC" EXACT [] synonym: "SCYA6" RELATED Gene-based [] synonym: "SCYA7" RELATED Gene-based [] synonym: "small-inducible cytokine A7" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000002190 name: RAC-alpha serine/threonine-protein kinase namespace: protein def: "An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "Akt" RELATED Gene-based [] synonym: "AKT1" EXACT PRO-short-label [PRO:DNx] synonym: "AKT1 kinase" EXACT [] synonym: "PKB" BROAD Gene-based [PRO:DNx] synonym: "PKB alpha" EXACT [] synonym: "protein kinase B" EXACT [] synonym: "protein kinase B alpha" EXACT [] synonym: "proto-oncogene c-Akt" EXACT [] synonym: "RAC" RELATED Gene-based [] synonym: "RAC-PK-alpha" EXACT [] synonym: "thymoma viral proto-oncogene" EXACT [] xref: IUPHARobj:1479 is_a: PR:000029189 ! AKT kinase [Term] id: PR:000002198 name: catenin beta-1 namespace: protein def: "A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "beta-catenin" EXACT [] synonym: "Catnb" RELATED Gene-based [] synonym: "CTNNB" RELATED Gene-based [] synonym: "CTNNB1" EXACT PRO-short-label [PRO:DNx] synonym: "OK/SW-cl.35" RELATED Gene-based [] synonym: "PRO2286" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000002201 name: dynein light chain namespace: protein def: "A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221)." [PRO:WCB] comment: Category=family. xref: PIRSF:PIRSF005695 is_a: PR:000000001 ! protein [Term] id: PR:000002204 name: lymphotoxin-alpha namespace: protein def: "A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "LT-alpha" EXACT [] synonym: "LTA" EXACT PRO-short-label [PRO:DNx] synonym: "TNF-beta" EXACT [] synonym: "TNFB" RELATED Gene-based [] synonym: "TNFSF1" RELATED Gene-based [] synonym: "tumor necrosis factor B" EXACT [PRO:DAN] synonym: "tumor necrosis factor ligand superfamily member 1" EXACT [] xref: PIRSF:PIRSF500469 is_a: PR:000050043 ! lymphotoxin [Term] id: PR:000003035 name: cellular tumor antigen p53 namespace: protein def: "A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "antigen NY-CO-13" EXACT [] synonym: "P53" RELATED Gene-based [] synonym: "phosphoprotein p53" EXACT [] synonym: "TP53" EXACT PRO-short-label [PRO:DNx] synonym: "Trp53" RELATED Gene-based [] synonym: "tumor suppressor p53" EXACT [] xref: PIRSF:PIRSF002089 is_a: PR:000000001 ! protein [Term] id: PR:000003112 name: NFAT protein namespace: protein def: "A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833)." [PRO:WCB] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000003113 name: nuclear factor of activated T-cells, cytoplasmic 1 namespace: protein def: "An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "NF-ATc" EXACT [] synonym: "NF-ATc1" EXACT [] synonym: "NFAT transcription complex cytosolic component" EXACT [] synonym: "NFAT2" RELATED Gene-based [] synonym: "NFATC" RELATED Gene-based [] synonym: "NFATc" EXACT [] synonym: "NFATC1" EXACT PRO-short-label [PRO:DNx] synonym: "NFATc1" EXACT [] is_a: PR:000003112 ! NFAT protein [Term] id: PR:000003237 name: 14-3-3 protein namespace: protein def: "A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain." [PRO:CNA] comment: Category=family. synonym: "fam:14-3-3" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF000868 is_a: PR:000000001 ! protein [Term] id: PR:000003425 name: Hsp70 family chaperone namespace: protein def: "A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain." [Pfam:PF00012, PRO:CNA] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000003652 name: acrosin namespace: protein def: "A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ACR" EXACT PRO-short-label [PRO:DNx] synonym: "ACRS" RELATED Gene-based [] xref: IUPHARobj:2327 is_a: PR:000000001 ! protein [Term] id: PR:000003761 name: pituitary adenylate cyclase-activating polypeptide namespace: protein def: "A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ADCYAP1" EXACT PRO-short-label [PRO:DNx] synonym: "PACAP" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003777 name: adiponectin namespace: protein def: "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "30 kDa adipocyte complement-related protein" EXACT [] synonym: "ACDC" RELATED Gene-based [] synonym: "ACRP30" RELATED Gene-based [] synonym: "adipocyte complement-related 30 kDa protein" EXACT [] synonym: "adipocyte, C1q and collagen domain-containing protein" EXACT [] synonym: "adipocyte-specific protein AdipoQ" EXACT [] synonym: "ADIPOQ" EXACT PRO-short-label [PRO:DNx] synonym: "adipose most abundant gene transcript 1 protein" EXACT [] synonym: "apM-1" EXACT [] synonym: "APM1" RELATED Gene-based [] synonym: "GBP28" RELATED Gene-based [] synonym: "gelatin-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003858 name: aryl hydrocarbon receptor namespace: protein def: "A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Ah receptor" EXACT [] synonym: "AHR" EXACT PRO-short-label [PRO:DNx] synonym: "AhR" EXACT [] synonym: "BHLHE76" RELATED Gene-based [] synonym: "bHLHe76" EXACT [] synonym: "class E basic helix-loop-helix protein 76" EXACT [] xref: IUPHARobj:2951 is_a: PR:000000001 ! protein [Term] id: PR:000004135 name: apelin namespace: protein def: "A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "APEL" RELATED Gene-based [] synonym: "APJ endogenous ligand" EXACT [] synonym: "APLN" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000004140 name: apolipoprotein A-I namespace: protein def: "A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "apo-AI" EXACT [] synonym: "ApoA-I" EXACT [] synonym: "APOA1" EXACT PRO-short-label [PRO:DNx] synonym: "apolipoprotein A1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004168 name: amyloid-beta precursor protein namespace: protein def: "A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=Alzforum. synonym: "A4" RELATED Gene-based [] synonym: "ABPP" EXACT [] synonym: "AD1" RELATED Gene-based [] synonym: "AG" EXACT [] synonym: "alzheimer disease amyloid A4 protein homolog" EXACT [] synonym: "alzheimer disease amyloid protein" EXACT [] synonym: "amyloid beta A4 protein" EXACT [] synonym: "amyloid precursor protein" EXACT [] synonym: "amyloid-beta (A4) precursor protein" EXACT [] synonym: "amyloid-beta A4 protein" EXACT [] synonym: "amyloidogenic glycoprotein" EXACT [] synonym: "APP" EXACT PRO-short-label [PRO:DNx] synonym: "APPI" EXACT [] synonym: "cerebral vascular amyloid peptide" EXACT [] synonym: "CVAP" EXACT [] synonym: "PN-II" EXACT [] synonym: "PreA4" EXACT [] synonym: "protease nexin-II" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004191 name: androgen receptor namespace: protein def: "A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "AR" EXACT PRO-short-label [PRO:DNx] synonym: "DHTR" RELATED Gene-based [] synonym: "dihydrotestosterone receptor" EXACT [] synonym: "NR3C4" RELATED Gene-based [] synonym: "nuclear receptor subfamily 3 group C member 4" EXACT [] xref: IUPHARobj:628 is_a: PR:000000001 ! protein [Term] id: PR:000004580 name: beta-2-microglobulin namespace: protein def: "A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "B2M" EXACT PRO-short-label [PRO:DNx] synonym: "CDABP0092" RELATED Gene-based [] synonym: "HDCMA22P" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000004716 name: brain-derived neurotrophic factor namespace: protein def: "A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "abrineurin" EXACT [] synonym: "BDNF" EXACT PRO-short-label [PRO:DNx] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000004972 name: calcitonin receptor namespace: protein def: "A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "CALCR" EXACT PRO-short-label [PRO:DNx] synonym: "CT-R" EXACT [] xref: IUPHARobj:43 is_a: PR:000044637 ! calcitonin receptor protein [Term] id: PR:000004978 name: calmodulin namespace: protein def: "A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN] comment: Category=gene. Note: The human CALM1, CALM2, and CALM3 genes encode identical proteins. synonym: "CALM" EXACT PRO-short-label [PRO:DNx] synonym: "CALML2" RELATED [] synonym: "CaM" EXACT [] synonym: "CAM3" NARROW [PRO:DAN] synonym: "CAMC" RELATED [] synonym: "CAMIII" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000005110 name: cholecystokinin namespace: protein def: "A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CCK" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000005388 name: glycoprotein hormones alpha chain namespace: protein def: "A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "anterior pituitary glycoprotein hormones common subunit alpha" EXACT [] synonym: "CG-alpha" EXACT [] synonym: "CGA" EXACT PRO-short-label [PRO:DNx] synonym: "choriogonadotropin alpha chain" EXACT [] synonym: "chorionic gonadotrophin subunit alpha" EXACT [] synonym: "follicle-stimulating hormone alpha chain" EXACT [] synonym: "follitropin alpha chain" EXACT [] synonym: "FSH-alpha" EXACT [] synonym: "LSH-alpha" EXACT [] synonym: "luteinizing hormone alpha chain" EXACT [] synonym: "lutropin alpha chain" EXACT [] synonym: "thyroid-stimulating hormone alpha chain" EXACT [] synonym: "thyrotropin alpha chain" EXACT [] synonym: "TSH-alpha" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005663 name: ciliary neurotrophic factor namespace: protein def: "A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CNTF" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000005869 name: corticotropin-releasing factor receptor 1 namespace: protein def: "A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "corticotropin-releasing hormone receptor 1" EXACT [] synonym: "CRF-R-1" EXACT [] synonym: "CRF-R1" EXACT [] synonym: "CRFR" RELATED Gene-based [] synonym: "CRFR-1" EXACT [] synonym: "CRFR1" RELATED Gene-based [] synonym: "CRH-R-1" EXACT [] synonym: "CRH-R1" EXACT [] synonym: "CRHR" RELATED Gene-based [] synonym: "CRHR1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:212 is_a: PR:000044630 ! corticotropin-releasing factor receptor [Term] id: PR:000005870 name: corticotropin-releasing factor receptor 2 namespace: protein def: "A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "corticotropin-releasing hormone receptor 2" EXACT [] synonym: "CRF-R-2" EXACT [] synonym: "CRF-R2" EXACT [] synonym: "CRF-RB" EXACT [] synonym: "CRF2R" RELATED Gene-based [] synonym: "CRFR-2" EXACT [] synonym: "CRH-R-2" EXACT [] synonym: "CRH-R2" EXACT [] synonym: "CRH2R" RELATED Gene-based [] synonym: "CRHR2" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:213 is_a: PR:000044630 ! corticotropin-releasing factor receptor [Term] id: PR:000005931 name: granulocyte-macrophage colony-stimulating factor namespace: protein def: "A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "colony-stimulating factor" EXACT [] synonym: "CSF" EXACT [] synonym: "CSF2" EXACT PRO-short-label [PRO:DNx] synonym: "Csfgm" RELATED Gene-based [] synonym: "GM-CSF" EXACT [] synonym: "GMCSF" RELATED Gene-based [] synonym: "molgramostin" EXACT [] synonym: "sargramostim" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005932 name: granulocyte colony-stimulating factor namespace: protein def: "A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "C17orf33" RELATED Gene-based [] synonym: "CSF3" EXACT PRO-short-label [PRO:DNx] synonym: "Csfg" RELATED Gene-based [] synonym: "filgrastim" EXACT [] synonym: "G-CSF" EXACT [] synonym: "GCSF" RELATED Gene-based [] synonym: "lenograstim" EXACT [] synonym: "pluripoietin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006013 name: catenin delta-2 namespace: protein def: "A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Catnd2" RELATED Gene-based [] synonym: "CTNND2" EXACT PRO-short-label [PRO:DNx] synonym: "delta-catenin" EXACT [] synonym: "GT24" EXACT [] synonym: "neural plakophilin-related ARM-repeat protein" EXACT [] synonym: "neurojungin" EXACT [] synonym: "NPRAP" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000006165 name: C-C motif chemokine 12 namespace: protein def: "An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Ccl12" EXACT PRO-short-label [PRO:DNx] synonym: "MCP-1-related chemokine" EXACT [] synonym: "MCP-5" BROAD [PRO:DAN] synonym: "Mcp5" RELATED Gene-based [] synonym: "monocyte chemoattractant protein 5" EXACT [] synonym: "monocyte chemotactic protein 5" EXACT [] synonym: "Scya12" RELATED Gene-based [] synonym: "small-inducible cytokine A12" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000006267 name: dystroglycan 1 namespace: protein def: "A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Dag-1" RELATED Gene-based [] synonym: "DAG1" EXACT PRO-short-label [PRO:DNx] synonym: "dystroglycan" EXACT [] synonym: "dystrophin-associated glycoprotein 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006909 name: elongation factor 2 namespace: protein def: "A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EEF2" EXACT PRO-short-label [PRO:DNx] synonym: "EF-2" EXACT [] synonym: "EF2" RELATED Gene-based [] xref: IUPHARobj:2756 is_a: PR:000000001 ! protein [Term] id: PR:000006928 name: pre-pro-epidermal growth factor namespace: protein def: "A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EGF" RELATED Gene-based [] synonym: "epidermal growth factor" RELATED [PRO:DAN] synonym: "pre-pro-EGF" EXACT PRO-short-label [PRO:DNx] synonym: "pro-epidermal growth factor" RELATED [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000006933 name: epidermal growth factor receptor namespace: protein def: "An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EGFR" EXACT PRO-short-label [PRO:DNx] synonym: "ERBB" RELATED Gene-based [] synonym: "ERBB1" RELATED Gene-based [] synonym: "HER1" RELATED Gene-based [] synonym: "proto-oncogene c-ErbB-1" EXACT [] synonym: "receptor tyrosine-protein kinase erbB-1" EXACT [] xref: IUPHARobj:1797 is_a: PR:000001812 ! EGF receptor type tyrosine-protein kinase [Term] id: PR:000006990 name: eukaryotic translation initiation factor 4E namespace: protein def: "A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "eIF-4E" EXACT [] synonym: "eIF-4F 25 kDa subunit" EXACT [] synonym: "EIF4E" EXACT PRO-short-label [PRO:DNx] synonym: "eIF4E" EXACT [] synonym: "EIF4EL1" RELATED Gene-based [] synonym: "EIF4F" RELATED Gene-based [] synonym: "mRNA cap-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007141 name: erythropoietin namespace: protein def: "A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EPO" EXACT PRO-short-label [PRO:DNx] synonym: "epoetin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007142 name: erythropoietin receptor namespace: protein def: "A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EPO-R" EXACT [] synonym: "EPOR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1718 is_a: PR:000000001 ! protein [Term] id: PR:000007204 name: estrogen receptor namespace: protein def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ER" EXACT [] synonym: "ER-alpha" EXACT [] synonym: "ESR" RELATED Gene-based [] synonym: "ESR1" EXACT PRO-short-label [PRO:DNx] synonym: "Estr" RELATED Gene-based [] synonym: "Estra" RELATED Gene-based [] synonym: "estradiol receptor" EXACT [] synonym: "NR3A1" RELATED Gene-based [] synonym: "nuclear receptor subfamily 3 group A member 1" EXACT [] xref: IUPHARobj:620 is_a: PR:000000001 ! protein [Term] id: PR:000007494 name: fibroblast growth factor 3 namespace: protein def: "A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FGF-3" EXACT [] synonym: "FGF3" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-3" EXACT [] synonym: "heparin-binding growth factor 3" EXACT [] synonym: "Int-2" RELATED Gene-based [] synonym: "INT-2 proto-oncogene protein" EXACT [] synonym: "INT2" RELATED Gene-based [] synonym: "proto-oncogene Int-2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007495 name: fibroblast growth factor 4 namespace: protein def: "A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FGF-4" EXACT [] synonym: "FGF4" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-4" EXACT [] synonym: "heparin secretory-transforming protein 1" EXACT [] synonym: "heparin-binding growth factor 4" EXACT [] synonym: "HST" BROAD Gene-based [PRO:DNx] synonym: "HST-1" EXACT [] synonym: "HSTF-1" EXACT [] synonym: "HSTF1" RELATED Gene-based [] synonym: "K-fibroblast growth factor" EXACT [] synonym: "Kfgf" RELATED Gene-based [] synonym: "KS3" RELATED Gene-based [] synonym: "transforming protein KS3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007496 name: fibroblast growth factor 5 namespace: protein def: "A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FGF-5" EXACT [] synonym: "FGF5" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-5" EXACT [] synonym: "heparin-binding growth factor 5" EXACT [] synonym: "Smag-82" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007497 name: fibroblast growth factor 6 namespace: protein def: "A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FGF-6" EXACT [] synonym: "FGF6" EXACT PRO-short-label [PRO:DNx] synonym: "HBGF-6" EXACT [] synonym: "heparin secretory-transforming protein 2" EXACT [] synonym: "heparin-binding growth factor 6" EXACT [] synonym: "HST-2" EXACT [] synonym: "HST2" RELATED Gene-based [] synonym: "HSTF-2" EXACT [] synonym: "HSTF2" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007555 name: filamin-A namespace: protein def: "A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABP-280" EXACT [] synonym: "actin-binding protein 280" EXACT [] synonym: "alpha-filamin" EXACT [] synonym: "endothelial actin-binding protein" EXACT [] synonym: "filamin-1" EXACT [] synonym: "FLN" RELATED Gene-based [] synonym: "FLN-A" EXACT [] synonym: "FLN1" RELATED Gene-based [] synonym: "FLNA" EXACT PRO-short-label [PRO:DNx] synonym: "non-muscle filamin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007556 name: filamin-B namespace: protein def: "A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABP-278" EXACT [] synonym: "ABP-280 homolog" EXACT [] synonym: "ABP-280-like protein" RELATED [] synonym: "actin-binding-like protein" BROAD [PRO:DNx] synonym: "beta-filamin" EXACT [] synonym: "Fh1" EXACT [] synonym: "filamin homolog 1" EXACT [] synonym: "filamin-3" EXACT [] synonym: "FLN-B" EXACT [] synonym: "FLN1L" RELATED Gene-based [] synonym: "FLN3" RELATED Gene-based [] synonym: "FLNB" EXACT PRO-short-label [PRO:DNx] synonym: "TABP" RELATED Gene-based [] synonym: "TAP" RELATED Gene-based [] synonym: "thyroid autoantigen" EXACT [] synonym: "truncated ABP" EXACT [] synonym: "truncated actin-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007557 name: filamin-C namespace: protein def: "A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABP-280-like protein" RELATED [] synonym: "ABP-L" EXACT [] synonym: "ABPL" RELATED Gene-based [] synonym: "actin-binding-like protein" BROAD [PRO:DNx] synonym: "filamin-2" EXACT [] synonym: "FLN-C" EXACT [] synonym: "FLN2" RELATED Gene-based [] synonym: "FLNC" EXACT PRO-short-label [PRO:DNx] synonym: "FLNc" EXACT [] synonym: "gamma-filamin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007563 name: vascular endothelial growth factor receptor 1 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "embryonic receptor kinase 2" EXACT [] synonym: "Emrk2" RELATED Gene-based [] synonym: "FLT" RELATED Gene-based [] synonym: "FLT-1" EXACT [] synonym: "FLT1" EXACT PRO-short-label [PRO:DNx] synonym: "Fms-like tyrosine kinase 1" EXACT [] synonym: "FRT" RELATED Gene-based [] synonym: "tyrosine-protein kinase FRT" EXACT [] synonym: "tyrosine-protein kinase receptor FLT" EXACT [] synonym: "vascular permeability factor receptor" EXACT [] synonym: "VEGFR-1" EXACT [] synonym: "VEGFR1" RELATED Gene-based [] xref: IUPHARobj:1812 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000007565 name: vascular endothelial growth factor receptor 3 namespace: protein def: "A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "FLT-4" EXACT [] synonym: "FLT4" EXACT PRO-short-label [PRO:DNx] synonym: "Fms-like tyrosine kinase 4" EXACT [] synonym: "tyrosine-protein kinase receptor FLT4" EXACT [] synonym: "VEGFR-3" EXACT [] synonym: "VEGFR3" RELATED Gene-based [] xref: IUPHARobj:1814 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000007581 name: fibronectin namespace: protein def: "A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CIG" EXACT [] synonym: "cold-insoluble globulin" EXACT [] synonym: "FN" RELATED Gene-based [] synonym: "FN1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007806 name: galanin namespace: protein def: "A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GAL" EXACT PRO-short-label [PRO:DNx] synonym: "GAL1" RELATED Gene-based [] synonym: "GALN" RELATED Gene-based [] synonym: "GLNN" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007856 name: gastrin namespace: protein def: "A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GAS" RELATED Gene-based [] synonym: "GAST" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007892 name: glucagon receptor namespace: protein def: "A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "GCGR" EXACT PRO-short-label [PRO:DNx] synonym: "GL-R" EXACT [] xref: IUPHARobj:251 is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000007893 name: GTP cyclohydrolase 1 namespace: protein def: "A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "DYT5" RELATED Gene-based [] synonym: "GCH" RELATED Gene-based [] synonym: "GCH1" EXACT PRO-short-label [PRO:DNx] synonym: "GTP cyclohydrolase I" BROAD [PRO:DNx] synonym: "GTP-CH-I" BROAD [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007928 name: glial cell line-derived neurotrophic factor namespace: protein def: "A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "astrocyte-derived trophic factor" EXACT [] synonym: "ATF" EXACT [] synonym: "GDNF" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000007970 name: growth hormone receptor namespace: protein def: "A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GH receptor" EXACT [] synonym: "GHR" EXACT PRO-short-label [PRO:DNx] synonym: "somatotropin receptor" EXACT [] xref: IUPHARobj:1720 is_a: PR:000000001 ! protein [Term] id: PR:000007971 name: somatoliberin namespace: protein def: "A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GHRF" RELATED Gene-based [] synonym: "GHRH" EXACT PRO-short-label [PRO:DNx] synonym: "GRF" EXACT [] synonym: "growth hormone-releasing factor" EXACT [] synonym: "growth hormone-releasing hormone" EXACT [] synonym: "sermorelin" EXACT [] synonym: "somatocrinin" EXACT [] synonym: "somatorelin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007972 name: growth hormone-releasing hormone receptor namespace: protein def: "A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "GHRH receptor" EXACT [] synonym: "GHRHR" EXACT PRO-short-label [PRO:DNx] synonym: "GRF receptor" EXACT [] synonym: "GRFR" EXACT [] synonym: "growth hormone-releasing factor receptor" EXACT [] xref: IUPHARobj:247 is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000007973 name: appetite-regulating hormone namespace: protein def: "A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GHRL" EXACT PRO-short-label [PRO:DNx] synonym: "growth hormone secretagogue" EXACT [] synonym: "growth hormone-releasing peptide" EXACT [] synonym: "motilin-related peptide" EXACT [] synonym: "MTLRP" RELATED Gene-based [] synonym: "protein M46" EXACT [] synonym: "UNQ524/PRO1066" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000007988 name: gastric inhibitory polypeptide receptor namespace: protein def: "A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "GIP-R" EXACT [] synonym: "GIPR" EXACT PRO-short-label [PRO:DNx] synonym: "glucose-dependent insulinotropic polypeptide receptor" EXACT [] xref: IUPHARobj:248 is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000008476 name: hypocretin neuropeptide precursor namespace: protein def: "A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HCRT" EXACT PRO-short-label [PRO:DNx] synonym: "Hcrt" EXACT [] synonym: "hypocretin" EXACT [] synonym: "orexin" EXACT [] synonym: "orexin precursor" EXACT [] synonym: "OX" RELATED Gene-based [] synonym: "PPORX" RELATED Gene-based [] synonym: "PPOX" RELATED Gene-based [] synonym: "prepro-orexin" EXACT [] synonym: "preprohypocretin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008534 name: hepatocyte growth factor namespace: protein def: "A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "hepatopoeitin-A" EXACT [] synonym: "hepatopoietin-A" EXACT [] synonym: "HGF" EXACT PRO-short-label [PRO:DNx] synonym: "HPTA" RELATED Gene-based [] synonym: "scatter factor" EXACT [] synonym: "SF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008630 name: high mobility group protein B1 namespace: protein def: "A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "high mobility group protein 1" EXACT [] synonym: "HMG-1" EXACT [] synonym: "HMG1" RELATED Gene-based [] synonym: "HMGB1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000008636 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase namespace: protein def: "A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HMG-CoA reductase" EXACT [] synonym: "HMGCR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:639 is_a: PR:000000001 ! protein [Term] id: PR:000008725 name: haptoglobin namespace: protein def: "A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HP" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000008875 name: islet amyloid polypeptide namespace: protein def: "A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "amylin" EXACT [] synonym: "DAP" BROAD [PRO:DNx] synonym: "diabetes-associated peptide" EXACT [] synonym: "IAPP" EXACT PRO-short-label [PRO:DNx] synonym: "insulinoma amyloid peptide" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008878 name: bone sialoprotein 2 namespace: protein def: "A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BNSP" RELATED Gene-based [] synonym: "bone sialoprotein II" EXACT [] synonym: "BSP II" EXACT [] synonym: "cell-binding sialoprotein" EXACT [] synonym: "IBSP" EXACT PRO-short-label [PRO:DNx] synonym: "integrin-binding sialoprotein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008888 name: isocitrate dehydrogenase [NADP], mitochondrial namespace: protein def: "A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ICD-M" EXACT [] synonym: "IDH" BROAD [PRO:DNx] synonym: "IDH2" RELATED Gene-based [] synonym: "IDH2nadp" EXACT PRO-short-label [PRO:DNx] synonym: "IDP" BROAD [PRO:DNx] synonym: "NADP(+)-specific ICDH" BROAD [PRO:DNx] synonym: "oxalosuccinate decarboxylase" BROAD [PRO:DNx] xref: IUPHARobj:2885 is_a: PR:000000001 ! protein [Term] id: PR:000008910 name: interferon-induced helicase C domain-containing protein 1 namespace: protein def: "A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "helicard" EXACT [] synonym: "helicase with 2 CARD domains" EXACT [] synonym: "IFIH1" EXACT PRO-short-label [PRO:DNx] synonym: "interferon induced with helicase C domain protein 1" EXACT [] synonym: "interferon-induced with helicase C domain protein 1" EXACT [] synonym: "MDA-5" EXACT [] synonym: "MDA5" RELATED Gene-based [] synonym: "melanoma differentiation-associated protein 5" EXACT [] synonym: "murabutide down-regulated protein" EXACT [] synonym: "RH116" RELATED Gene-based [] synonym: "RIG-I-like receptor 2" EXACT [] synonym: "RLR-2" EXACT [] synonym: "RNA helicase-DEAD box protein 116" EXACT [] xref: IUPHARobj:2921 is_a: PR:000000001 ! protein [Term] id: PR:000008942 name: insulin-like growth factor II namespace: protein def: "A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Igf-2" RELATED Gene-based [] synonym: "IGF-II" EXACT [] synonym: "IGF2" EXACT PRO-short-label [PRO:DNx] synonym: "multiplication-stimulating polypeptide" EXACT [] synonym: "PP1446" RELATED Gene-based [] synonym: "somatomedin-A" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008998 name: interleukin-21 receptor namespace: protein def: "A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CD360" EXACT [ImmPort:DSD] synonym: "IL-21 receptor" EXACT [] synonym: "IL-21R" EXACT [] synonym: "IL21R" EXACT PRO-short-label [PRO:DNx] synonym: "LR-beta" EXACT [] synonym: "lymphocyte receptor beta" EXACT [] synonym: "NILR" RELATED Gene-based [] synonym: "novel cytokine receptor 8" EXACT [] synonym: "novel interleukin receptor" EXACT [] synonym: "NR8" EXACT [] synonym: "UNQ3121/PRO10273" RELATED Gene-based [] xref: IUPHARobj:1703 is_a: PR:000000001 ! protein [Term] id: PR:000009001 name: interleukin-23 receptor namespace: protein def: "A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "IL-23 receptor" EXACT [] synonym: "IL-23R" EXACT [] synonym: "IL23R" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1717 is_a: PR:000000001 ! protein [Term] id: PR:000009054 name: insulin gene translation product namespace: protein def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "INS" EXACT PRO-short-label [PRO:DNx] synonym: "insulin" BROAD [PRO:DAN] is_a: PR:000045358 ! insulin family protein [Term] id: PR:000009064 name: insulin receptor namespace: protein def: "A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CD220" EXACT [] synonym: "INSR" EXACT PRO-short-label [PRO:DNx] synonym: "IR" EXACT [] xref: IUPHARobj:1800 is_a: PR:000000001 ! protein [Term] id: PR:000009182 name: insulin-like growth factor I namespace: protein def: "A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "IBP1" RELATED Gene-based [] synonym: "Igf-1" RELATED Gene-based [] synonym: "IGF-I" BROAD [PRO:DNx] synonym: "IGF1" EXACT PRO-short-label [PRO:DNx] synonym: "mechano growth factor" EXACT [] synonym: "MGF" BROAD [PRO:DNx] synonym: "somatomedin" EXACT [] synonym: "somatomedin-C" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009345 name: kit ligand namespace: protein def: "A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "c-Kit ligand" EXACT [] synonym: "hematopoietic growth factor KL" EXACT [] synonym: "Kitl" RELATED Gene-based [] synonym: "KITLG" EXACT PRO-short-label [PRO:DNx] synonym: "mast cell growth factor" RELATED [] synonym: "MGF" BROAD Gene-based [PRO:DNx] synonym: "SCF" RELATED Gene-based [] synonym: "Sl" RELATED Gene-based [] synonym: "Slf" RELATED Gene-based [] synonym: "steel factor" EXACT [] synonym: "stem cell factor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009799 name: leukemia inhibitory factor namespace: protein def: "A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "D factor" EXACT [] synonym: "differentiation-stimulating factor" EXACT [] synonym: "emfilermin" EXACT [] synonym: "HILDA" RELATED Gene-based [] synonym: "LIF" EXACT PRO-short-label [PRO:DNx] synonym: "melanoma-derived LPL inhibitor" EXACT [] synonym: "MLPLI" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009978 name: lactotransferrin namespace: protein def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. synonym: "GIG12" RELATED Gene-based [] synonym: "lactoferrin" EXACT [] synonym: "LF" RELATED Gene-based [] synonym: "LTF" EXACT PRO-short-label [PRO:DNx] synonym: "talalactoferrin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010335 name: hepatocyte growth factor receptor namespace: protein def: "An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HGF receptor" EXACT [] synonym: "HGF/SF receptor" EXACT [] synonym: "MET" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Met" EXACT [] synonym: "scatter factor receptor" EXACT [] synonym: "SF receptor" EXACT [] synonym: "tyrosine-protein kinase Met" EXACT [] xref: IUPHARobj:1815 is_a: PR:000001816 ! HGF/MSP receptor type tyrosine-protein kinase [Term] id: PR:000010413 name: macrophage migration inhibitory factor namespace: protein def: "A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "delayed early response protein 6" EXACT [] synonym: "DER6" EXACT [] synonym: "GIF" RELATED [] synonym: "GLIF" RELATED Gene-based [] synonym: "glycosylation-inhibiting factor" EXACT [] synonym: "L-dopachrome isomerase" EXACT [] synonym: "L-dopachrome tautomerase" RELATED [] synonym: "MIF" EXACT PRO-short-label [PRO:DNx] synonym: "MMIF" RELATED Gene-based [] synonym: "phenylpyruvate tautomerase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010444 name: mitogen-activated protein kinase kinase kinase 21 namespace: protein def: "A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "KIAA1804" RELATED Gene-based [] synonym: "MAP3K21" EXACT PRO-short-label [PRO:DNx] synonym: "mitogen-activated protein kinase kinase kinase MLK4" EXACT [] synonym: "mixed lineage kinase 4" EXACT [] synonym: "MLK4" RELATED Gene-based [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000010818 name: myogenic factor 5 namespace: protein def: "A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BHLHC2" RELATED Gene-based [] synonym: "bHLHc2" EXACT [] synonym: "class C basic helix-loop-helix protein 2" EXACT [] synonym: "Myf-5" RELATED Gene-based [] synonym: "MYF5" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000010855 name: myosin-Ia namespace: protein def: "A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BBM-I" EXACT [] synonym: "BBMI" EXACT [] synonym: "brush border myosin I" EXACT [] synonym: "MIHC" EXACT [] synonym: "MYHL" RELATED Gene-based [] synonym: "MYO1A" EXACT PRO-short-label [PRO:DNx] synonym: "myosin I heavy chain" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010877 name: myogenin namespace: protein def: "A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BHLHC3" RELATED Gene-based [] synonym: "bHLHc3" EXACT [] synonym: "class C basic helix-loop-helix protein 3" EXACT [] synonym: "Myf-4" EXACT [] synonym: "MYF4" RELATED Gene-based [] synonym: "MYOD1-related protein" EXACT [] synonym: "MYOG" EXACT PRO-short-label [PRO:DNx] synonym: "myogenic factor 4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010882 name: myozenin-1 namespace: protein def: "A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "calsarcin-2" EXACT [] synonym: "filamin-, actinin- and telethonin-binding protein" EXACT [] synonym: "MYOZ" RELATED Gene-based [] synonym: "MYOZ1" EXACT PRO-short-label [PRO:DNx] synonym: "protein FATZ" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011116 name: NEDD8 protein namespace: protein def: "A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NEDD-8" EXACT [] synonym: "NEDD8" EXACT PRO-short-label [PRO:DNx] synonym: "neddylin" EXACT [] synonym: "neural precursor cell expressed developmentally down-regulated protein 8" EXACT [] synonym: "ubiquitin-like protein Nedd8" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011164 name: nuclear factor of activated T-cells, cytoplasmic 2 namespace: protein def: "A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NF-ATc2" EXACT [] synonym: "NF-ATp" EXACT [] synonym: "NFAT pre-existing subunit" EXACT [] synonym: "NFAT1" RELATED Gene-based [] synonym: "NFATC2" EXACT PRO-short-label [PRO:DNx] synonym: "NFATc2" EXACT [] synonym: "NFATP" RELATED Gene-based [] synonym: "T-cell transcription factor NFAT1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011166 name: nuclear factor of activated T-cells, cytoplasmic 3 namespace: protein def: "A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NF-AT4" EXACT [] synonym: "NF-ATc3" EXACT [] synonym: "NFAT4" RELATED Gene-based [] synonym: "NFATC3" EXACT PRO-short-label [PRO:DNx] synonym: "NFATc3" EXACT [] synonym: "NFATx" EXACT [] synonym: "T-cell transcription factor NFAT4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011167 name: nuclear factor of activated T-cells, cytoplasmic 4 namespace: protein def: "A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NF-AT3" EXACT [] synonym: "NF-ATc4" EXACT [] synonym: "NFAT3" RELATED Gene-based [] synonym: "NFATC4" EXACT PRO-short-label [PRO:DNx] synonym: "NFATc4" EXACT [] synonym: "T-cell transcription factor NFAT3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011194 name: beta-nerve growth factor namespace: protein def: "A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "beta-NGF" EXACT [] synonym: "NGF" EXACT PRO-short-label [PRO:DNx] synonym: "NGFB" RELATED Gene-based [] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000011374 name: atrial natriuretic factor namespace: protein def: "A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ANF" EXACT [] synonym: "ANP" RELATED Gene-based [] synonym: "atrial natriuretic factor prohormone" EXACT [] synonym: "atrial natriuretic peptide" EXACT [] synonym: "atrial natriuretic peptide prohormone" EXACT [] synonym: "atriopeptigen" EXACT [] synonym: "cardiodilatin" EXACT [] synonym: "CDD" EXACT [] synonym: "CDD-ANF" EXACT [] synonym: "NPPA" EXACT PRO-short-label [PRO:DNx] synonym: "PND" RELATED Gene-based [] synonym: "preproANP" EXACT [] synonym: "preproCDD-ANF" EXACT [] synonym: "prepronatriodilatin" EXACT [] synonym: "proANF" EXACT [] synonym: "proANP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011387 name: neuropeptide Y namespace: protein def: "A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NPY" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000011406 name: glucocorticoid receptor namespace: protein def: "A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GR" RELATED [] synonym: "GRL" RELATED Gene-based [] synonym: "Grl1" RELATED Gene-based [] synonym: "NR3C1" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 3 group C member 1" EXACT [] xref: IUPHARobj:625 is_a: PR:000000001 ! protein [Term] id: PR:000011407 name: mineralocorticoid receptor namespace: protein def: "A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "MCR" RELATED Gene-based [] synonym: "MLR" RELATED Gene-based [] synonym: "MR" EXACT [] synonym: "NR3C2" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 3 group C member 2" EXACT [] xref: IUPHARobj:626 is_a: PR:000000001 ! protein [Term] id: PR:000011459 name: neurotrophin-3 namespace: protein def: "A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HDNF" EXACT [] synonym: "nerve growth factor 2" EXACT [] synonym: "neurotrophic factor" EXACT [] synonym: "NGF-2" EXACT [] synonym: "NT-3" EXACT [] synonym: "Ntf-3" RELATED Gene-based [] synonym: "NTF3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000012059 name: oncostatin-M namespace: protein def: "A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "OSM" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000012421 name: proliferating cell nuclear antigen namespace: protein def: "A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "cyclin" EXACT [] synonym: "PCNA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000012621 name: progesterone receptor namespace: protein def: "A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NR3C3" RELATED Gene-based [] synonym: "nuclear receptor subfamily 3 group C member 3" EXACT [] synonym: "PGR" EXACT PRO-short-label [PRO:DNx] synonym: "PR" EXACT [] xref: IUPHARobj:627 is_a: PR:000000001 ! protein [Term] id: PR:000012705 name: polymeric immunoglobulin receptor namespace: protein def: "A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "hepatocellular carcinoma-associated protein TB6" EXACT [] synonym: "PIGR" EXACT PRO-short-label [PRO:DNx] synonym: "PIgR" EXACT [] synonym: "poly-Ig receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012826 name: urokinase-type plasminogen activator namespace: protein def: "A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PLAU" EXACT PRO-short-label [PRO:DNx] synonym: "U-plasminogen activator" EXACT [] synonym: "uPA" EXACT [] xref: IUPHARobj:2393 is_a: PR:000000001 ! protein [Term] id: PR:000013164 name: pancreatic polypeptide prohormone namespace: protein def: "A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "obinepitide" EXACT [] synonym: "pancreatic polypeptide" EXACT [] synonym: "pancreatic prohormone" EXACT [] synonym: "PNP" RELATED Gene-based [] synonym: "PP" EXACT [] synonym: "PPY" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000013246 name: prolactin namespace: protein def: "A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PRL" EXACT PRO-short-label [PRO:DNx] is_a: PR:000029968 ! somatotropin hormone family member [Term] id: PR:000013248 name: prolactin receptor namespace: protein def: "A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PRL-R" EXACT [] synonym: "PRLR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:1721 is_a: PR:000000001 ! protein [Term] id: PR:000013429 name: parathyroid hormone namespace: protein def: "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "parathormone" EXACT [] synonym: "parathyrin" EXACT [] synonym: "PTH" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000013526 name: peptide YY namespace: protein def: "A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "peptide tyrosine tyrosine" EXACT [] synonym: "PYY" EXACT PRO-short-label [PRO:DNx] synonym: "PYY-I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013743 name: Ras GTPase-activating protein 1 namespace: protein def: "A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GAP" BROAD Gene-based [PRO:DNx] synonym: "GTPase-activating protein" EXACT [] synonym: "p120GAP" EXACT [] synonym: "ras p21 protein activator" EXACT [] synonym: "RASA" RELATED Gene-based [] synonym: "RASA1" EXACT PRO-short-label [PRO:DNx] synonym: "RasGAP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013883 name: renin namespace: protein def: "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "angiotensinogenase" RELATED [] synonym: "REN" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2413 is_a: PR:000050025 ! angiotensinogenase [Term] id: PR:000014271 name: ubiquitin-ribosomal protein eS31 fusion protein namespace: protein def: "A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "40S ribosomal protein S27a" RELATED [] synonym: "RPS27A" EXACT PRO-short-label [PRO:DNx] synonym: "UBA80" RELATED Gene-based [] synonym: "UBCEP1" RELATED Gene-based [] synonym: "ubiquitin carboxyl extension protein 80" EXACT [] synonym: "ubiquitin-40S ribosomal protein S27a" EXACT [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000014543 name: secretin namespace: protein def: "A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "SCT" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000014544 name: secretin receptor namespace: protein def: "A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "SCT-R" EXACT [] synonym: "SCTR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:252 is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000014717 name: protein SET namespace: protein def: "A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HLA-DR-associated protein II" NARROW [PRO:DAN] synonym: "I-2PP2A" EXACT [] synonym: "IGAAD" EXACT [] synonym: "inhibitor of granzyme A-activated DNase" EXACT [] synonym: "PHAPII" EXACT [] synonym: "phosphatase 2A inhibitor I2PP2A" EXACT [] synonym: "SET" EXACT PRO-short-label [PRO:DNx] synonym: "TAF-I" EXACT [] synonym: "template-activating factor I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000015288 name: protein smoothened namespace: protein def: "A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "protein Gx" EXACT [] synonym: "SMO" EXACT PRO-short-label [PRO:DNx] synonym: "SMOH" RELATED Gene-based [] xref: IUPHARobj:239 is_a: PR:000001315 ! frizzled-like G-protein coupled receptor [Term] id: PR:000015794 name: syntaxin-2 namespace: protein def: "A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EPIM" RELATED Gene-based [] synonym: "epimorphin" EXACT [] synonym: "STX2" EXACT PRO-short-label [PRO:DNx] synonym: "STX2A" RELATED Gene-based [] synonym: "STX2B" RELATED Gene-based [] synonym: "STX2C" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000015795 name: syntaxin-3 namespace: protein def: "A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "STX3" EXACT PRO-short-label [PRO:DNx] synonym: "STX3A" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000015797 name: syntaxin-5 namespace: protein def: "A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "STX5" EXACT PRO-short-label [PRO:DNx] synonym: "STX5A" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000015798 name: syntaxin-6 namespace: protein def: "A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "STX6" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000016051 name: antigen peptide transporter 1 namespace: protein def: "A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABCB2" RELATED Gene-based [] synonym: "APT1" EXACT [] synonym: "ATP-binding cassette sub-family B member 2" EXACT [] synonym: "Ham-1" RELATED Gene-based [] synonym: "Ham1" RELATED Gene-based [] synonym: "histocompatibility antigen modifier 1" EXACT [] synonym: "peptide supply factor 1" EXACT [] synonym: "peptide transporter involved in antigen processing 1" EXACT [] synonym: "peptide transporter PSF1" EXACT [] synonym: "peptide transporter TAP1" EXACT [] synonym: "PSF-1" EXACT [] synonym: "PSF1" RELATED Gene-based [] synonym: "really interesting new gene 4 protein" EXACT [] synonym: "RING4" RELATED Gene-based [] synonym: "TAP1" EXACT PRO-short-label [PRO:DNx] synonym: "Y3" RELATED Gene-based [] xref: IUPHARobj:769 is_a: PR:000000001 ! protein [Term] id: PR:000016052 name: antigen peptide transporter 2 namespace: protein def: "A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABCB3" RELATED Gene-based [] synonym: "APT2" EXACT [] synonym: "ATP-binding cassette sub-family B member 3" EXACT [] synonym: "Ham-2" RELATED Gene-based [] synonym: "Ham2" RELATED Gene-based [] synonym: "histocompatibility antigen modifier 2" EXACT [] synonym: "peptide supply factor 2" EXACT [] synonym: "peptide transporter involved in antigen processing 2" EXACT [] synonym: "peptide transporter PSF2" EXACT [] synonym: "peptide transporter TAP2" EXACT [] synonym: "PSF-2" EXACT [] synonym: "PSF2" RELATED Gene-based [] synonym: "really interesting new gene 11 protein" EXACT [] synonym: "RING11" RELATED Gene-based [] synonym: "TAP2" EXACT PRO-short-label [PRO:DNx] synonym: "Y1" RELATED Gene-based [] xref: IUPHARobj:770 is_a: PR:000000001 ! protein [Term] id: PR:000016053 name: tapasin namespace: protein def: "A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "NGS-17" EXACT [] synonym: "NGS17" RELATED Gene-based [] synonym: "TAP-associated protein" EXACT [] synonym: "TAP-binding protein" EXACT [] synonym: "TAPA" RELATED Gene-based [] synonym: "TAPBP" EXACT PRO-short-label [PRO:DNx] synonym: "TPN" EXACT [] synonym: "TPSN" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016156 name: telethonin namespace: protein def: "A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "TCAP" EXACT PRO-short-label [PRO:DNx] synonym: "titin cap protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016261 name: serotransferrin namespace: protein def: "A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "beta-1 metal-binding globulin" EXACT [] synonym: "PRO1400" RELATED Gene-based [] synonym: "siderophilin" EXACT [] synonym: "TF" EXACT PRO-short-label [PRO:DNx] synonym: "transferrin" EXACT [] synonym: "Trf" RELATED Gene-based [] is_a: PR:000000001 ! protein [Term] id: PR:000016301 name: tyrosine 3-monooxygenase namespace: protein def: "A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "TH" EXACT PRO-short-label [PRO:DNx] synonym: "TYH" RELATED Gene-based [] synonym: "tyrosine 3-hydroxylase" EXACT [] xref: IUPHARobj:1243 is_a: PR:000000001 ! protein [Term] id: PR:000016542 name: type 1B DNA topoisomerase 1 namespace: protein def: "A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "DNA topoisomerase I" BROAD [PRO:DNx] synonym: "Top-1" RELATED Gene-based [] synonym: "TOP1" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2636 is_a: PR:000000001 ! protein [Term] id: PR:000016724 name: thyrotropin subunit beta namespace: protein def: "A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "thyroid-stimulating hormone subunit beta" EXACT [] synonym: "thyrotropin alfa" EXACT [] synonym: "thyrotropin beta chain" EXACT [] synonym: "TSH-B" EXACT [] synonym: "TSH-beta" EXACT [] synonym: "TSHB" EXACT PRO-short-label [PRO:DNx] is_a: PR:000044813 ! glycoprotein hormone beta chain [Term] id: PR:000016798 name: titin namespace: protein def: "A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "connectin" EXACT [] synonym: "rhabdomyosarcoma antigen MU-RMS-40.14" EXACT [] synonym: "TTN" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:2265 is_a: PR:000000001 ! protein [Term] id: PR:000016954 name: ubiquitin-ribosomal protein eL40 fusion protein namespace: protein def: "A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "60S ribosomal protein L40" RELATED [] synonym: "CEP52" EXACT [] synonym: "UBA52" EXACT PRO-short-label [PRO:DNx] synonym: "UBCEP2" RELATED Gene-based [] synonym: "ubiquitin A-52 residue ribosomal protein fusion product 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016963 name: polyubiquitin-C namespace: protein def: "A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "UBC" EXACT PRO-short-label [PRO:DNx] is_a: PR:000036929 ! tandem-copy polyubiquitin [Term] id: PR:000016964 name: ubiquitin D namespace: protein def: "A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "diubiquitin" EXACT [] synonym: "FAT10" RELATED Gene-based [] synonym: "UBD" EXACT PRO-short-label [PRO:DNx] synonym: "ubiquitin-like protein FAT10" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000017272 name: vinculin namespace: protein def: "A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "metavinculin" EXACT [] synonym: "VCL" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000017283 name: vitamin D3 receptor namespace: protein def: "A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "1,25-dihydroxyvitamin D3 receptor" EXACT [] synonym: "NR1I1" RELATED Gene-based [] synonym: "nuclear receptor subfamily 1 group I member 1" EXACT [] synonym: "VDR" EXACT PRO-short-label [PRO:DNx] xref: IUPHARobj:605 is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [PRO:DAN, PRO:JSG] comment: Category=polymer. synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: CHEBI:50047 relationship: has_constituent_monomer CHEBI:33708 {minCardinality="2"} [Term] id: PR:000018264 name: proteolytic cleavage product namespace: protein def: "A protein that is produced as the result of proteolytic processing of a longer protein." [PRO:DAN] synonym: "ClvPrd" EXACT PRO-short-label [PRO:DAN] synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018271 name: interferon gamma proteolytic cleavage product namespace: protein def: "An interferon gamma that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IFNG/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000017 ! interferon gamma is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000000017 ! interferon gamma intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018435 name: pro-interleukin-16 proteolytic cleavage product namespace: protein def: "A pro-interleukin-16 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IL16/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001374 ! pro-interleukin-16 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001374 ! pro-interleukin-16 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018438 name: interleukin-18 proteolytic cleavage product namespace: protein def: "An interleukin-18 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IL18/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001376 ! interleukin-18 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001376 ! interleukin-18 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018461 name: interleukin-8 proteolytic cleavage product namespace: protein def: "An interleukin-8 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CXCL8/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001395 ! interleukin-8 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001395 ! interleukin-8 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018513 name: proteinase-activated receptor 1 proteolytic cleavage product namespace: protein def: "A proteinase-activated receptor 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "F2R/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001661 ! proteinase-activated receptor 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001661 ! proteinase-activated receptor 1 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018718 name: C-C motif chemokine 5 proteolytic cleavage product namespace: protein def: "A C-C motif chemokine 5 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CCL5/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002094 ! C-C motif chemokine 5 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000002094 ! C-C motif chemokine 5 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018721 name: tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product namespace: protein def: "A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "TNFSF11/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018880 name: acrosin proteolytic cleavage product namespace: protein def: "An acrosin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ACR/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003652 ! acrosin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003652 ! acrosin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018902 name: pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product namespace: protein def: "A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ADCYAP1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003761 ! pituitary adenylate cyclase-activating polypeptide is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003761 ! pituitary adenylate cyclase-activating polypeptide intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000018934 name: aryl hydrocarbon receptor proteolytic cleavage product namespace: protein def: "An aryl hydrocarbon receptor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "AHR/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003858 ! aryl hydrocarbon receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003858 ! aryl hydrocarbon receptor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019010 name: apolipoprotein A-I proteolytic cleavage product namespace: protein def: "An apolipoprotein A-I that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "APOA1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004140 ! apolipoprotein A-I is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004140 ! apolipoprotein A-I intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019036 name: amyloid-beta precursor protein proteolytic cleavage product namespace: protein def: "An amyloid-beta precursor protein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. Requested by=Alzforum. synonym: "APP/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004168 ! amyloid-beta precursor protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004168 ! amyloid-beta precursor protein intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019110 name: beta-2-microglobulin proteolytic cleavage product namespace: protein def: "A beta-2-microglobulin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "B2M/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004580 ! beta-2-microglobulin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004580 ! beta-2-microglobulin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019130 name: brain-derived neurotrophic factor proteolytic cleavage product namespace: protein def: "A brain-derived neurotrophic factor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "BDNF/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004716 ! brain-derived neurotrophic factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004716 ! brain-derived neurotrophic factor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019255 name: cholecystokinin proteolytic cleavage product namespace: protein def: "A cholecystokinin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CCK/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000005110 ! cholecystokinin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000005110 ! cholecystokinin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019642 name: dystroglycan 1 proteolytic cleavage product namespace: protein def: "A dystroglycan 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "DAG1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000006267 ! dystroglycan 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006267 ! dystroglycan 1 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019798 name: erythropoietin proteolytic cleavage product namespace: protein def: "An erythropoietin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "EPO/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007141 ! erythropoietin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007141 ! erythropoietin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019919 name: fibronectin proteolytic cleavage product namespace: protein def: "A fibronectin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "FN1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007581 ! fibronectin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007581 ! fibronectin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019959 name: galanin proteolytic cleavage product namespace: protein def: "A galanin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GAL/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007806 ! galanin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007806 ! galanin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019973 name: gastrin proteolytic cleavage product namespace: protein def: "A gastrin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GAST/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007856 ! gastrin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007856 ! gastrin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019995 name: growth hormone receptor proteolytic cleavage product namespace: protein def: "A growth hormone receptor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GHR/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007970 ! growth hormone receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007970 ! growth hormone receptor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019996 name: somatoliberin proteolytic cleavage product namespace: protein def: "A somatoliberin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GHRH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007971 ! somatoliberin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007971 ! somatoliberin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000019999 name: appetite-regulating hormone proteolytic cleavage product namespace: protein def: "An appetite-regulating hormone that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "GHRL/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000007973 ! appetite-regulating hormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007973 ! appetite-regulating hormone intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020124 name: hypocretin neuropeptide precursor proteolytic cleavage product namespace: protein def: "A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "HCRT/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008476 ! hypocretin neuropeptide precursor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008476 ! hypocretin neuropeptide precursor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020135 name: hepatocyte growth factor proteolytic cleavage product namespace: protein def: "A hepatocyte growth factor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "HGF/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008534 ! hepatocyte growth factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008534 ! hepatocyte growth factor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020180 name: haptoglobin proteolytic cleavage product namespace: protein def: "A haptoglobin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "HP/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008725 ! haptoglobin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008725 ! haptoglobin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020226 name: islet amyloid polypeptide proteolytic cleavage product namespace: protein def: "An islet amyloid polypeptide that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IAPP/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008875 ! islet amyloid polypeptide is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008875 ! islet amyloid polypeptide intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020267 name: insulin-like growth factor II proteolytic cleavage product namespace: protein def: "An insulin-like growth factor II that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IGF2/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008942 ! insulin-like growth factor II is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008942 ! insulin-like growth factor II intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020320 name: insulin receptor proteolytic cleavage product namespace: protein def: "An insulin receptor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "INSR/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009064 ! insulin receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009064 ! insulin receptor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020357 name: insulin-like growth factor I proteolytic cleavage product namespace: protein def: "An insulin-like growth factor I that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IGF1/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009182 ! insulin-like growth factor I is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009182 ! insulin-like growth factor I intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020497 name: lactotransferrin proteolytic cleavage product namespace: protein def: "A lactotransferrin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "LTF/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000009978 ! lactotransferrin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009978 ! lactotransferrin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020722 name: NEDD8 protein proteolytic cleavage product namespace: protein def: "A NEDD8 protein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NEDD8/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011116 ! NEDD8 protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011116 ! NEDD8 protein intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020737 name: beta-nerve growth factor proteolytic cleavage product namespace: protein def: "A beta-nerve growth factor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NGF/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011194 ! beta-nerve growth factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011194 ! beta-nerve growth factor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020775 name: atrial natriuretic factor proteolytic cleavage product namespace: protein def: "An atrial natriuretic factor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NPPA/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011374 ! atrial natriuretic factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011374 ! atrial natriuretic factor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020789 name: neuropeptide Y proteolytic cleavage product namespace: protein def: "A neuropeptide Y that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NPY/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011387 ! neuropeptide Y is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011387 ! neuropeptide Y intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020795 name: neurotrophin-3 proteolytic cleavage product namespace: protein def: "A neurotrophin-3 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NTF3/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000011459 ! neurotrophin-3 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011459 ! neurotrophin-3 intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020841 name: oncostatin-M proteolytic cleavage product namespace: protein def: "An oncostatin-M that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "OSM/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000012059 ! oncostatin-M is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012059 ! oncostatin-M intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000020966 name: polymeric immunoglobulin receptor proteolytic cleavage product namespace: protein def: "A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PIGR/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000012705 ! polymeric immunoglobulin receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012705 ! polymeric immunoglobulin receptor intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021003 name: urokinase-type plasminogen activator proteolytic cleavage product namespace: protein def: "A urokinase-type plasminogen activator that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PLAU/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000012826 ! urokinase-type plasminogen activator is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012826 ! urokinase-type plasminogen activator intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021066 name: pancreatic polypeptide prohormone proteolytic cleavage product namespace: protein def: "A pancreatic polypeptide prohormone that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PPY/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013164 ! pancreatic polypeptide prohormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013164 ! pancreatic polypeptide prohormone intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021170 name: parathyroid hormone proteolytic cleavage product namespace: protein def: "A parathyroid hormone that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PTH/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013429 ! parathyroid hormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013429 ! parathyroid hormone intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021195 name: peptide YY proteolytic cleavage product namespace: protein def: "A peptide YY that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PYY/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013526 ! peptide YY is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013526 ! peptide YY intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021385 name: secretin proteolytic cleavage product namespace: protein def: "A secretin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "SCT/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000014543 ! secretin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000014543 ! secretin intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021742 name: thyrotropin subunit beta proteolytic cleavage product namespace: protein def: "A thyrotropin subunit beta that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "TSHB/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000016724 ! thyrotropin subunit beta is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000016724 ! thyrotropin subunit beta intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000021998 name: neurotrophin namespace: protein def: "A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain." [PMID:10388563] comment: Category=family. xref: PIRSF:PIRSF001789 is_a: PR:000000001 ! protein [Term] id: PR:000021999 name: death receptor namespace: protein def: "A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling." [PMID:12655292] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000022358 name: adenylate cyclase namespace: protein def: "A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "adenylyl cyclase" EXACT [] synonym: "ATP pyrophosphate-lyase" EXACT [] synonym: "cya" RELATED [] synonym: "cyaA" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000024025 name: methyl-accepting chemotaxis protein IV namespace: protein def: "A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "dipeptide chemoreceptor protein" EXACT [] synonym: "MCP-IV" EXACT [] synonym: "tap" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000024067 name: homoserine kinase namespace: protein def: "A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HK" EXACT [] synonym: "HSK" EXACT [] synonym: "thrB" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000024990 name: type II interferon namespace: protein def: "A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains." [PMID:9607096, PRO:DAN, PRO:MSY] comment: Category=family. Note: Some references consider 'gamma' and 'type II' to be synonyms. This is likely because gamma is the only type II interferon identified. However, the classification criteria for each nomenclature system differ. synonym: "IFN type II" EXACT [] synonym: "interferon gamma" RELATED [] synonym: "interferon type II" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000025350 name: HSPC protein namespace: protein def: "An Hsp70 family chaperone that contains an ATPase and HSP90 domains." [PMID:18663603, PRO:DAN] comment: Category=family. synonym: "HSP90" EXACT [] is_a: PR:000003425 ! Hsp70 family chaperone [Term] id: PR:000025433 name: nodal protein proteolytic cleavage product namespace: protein def: "A nodal protein that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "NODAL/ClvPrd" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000105 ! nodal protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000000105 ! nodal protein intersection_of: RO:0002353 GO:0016485 relationship: RO:0002353 GO:0016485 [Term] id: PR:000025845 name: ephrin receptor namespace: protein def: "A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647)." [PRO:DAN] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000025848 name: type I interferon namespace: protein def: "A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains." [PMID:15233997, PMID:9607096, PRO:DAN, PRO:MSY] comment: Category=family. synonym: "IFN type I" EXACT [] synonym: "interferon type I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000028205 name: type III interferon namespace: protein def: "A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2." [PMID:9607096] comment: Category=family. Note: Some references consider 'lambda' and 'type III' to be synonyms. This is likely because lambda is the only type III interferon identified. However, the classification criteria for each nomenclature system differ. synonym: "IFN type III" EXACT [] synonym: "interferon lambda" RELATED [] synonym: "interferon type III" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000028269 name: thyroid stimulating hormone namespace: protein def: "A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone." [PRO:MSY] comment: Category=complex. Requested by=GOC. synonym: "thyrotropin" EXACT [] synonym: "TSH" EXACT [] is_a: GO:0032991 relationship: RO:0002180 PR:000005388 {cardinality="1"} ! glycoprotein hormones alpha chain relationship: RO:0002180 PR:000016724 {cardinality="1"} ! thyrotropin subunit beta [Term] id: PR:000029189 name: AKT kinase namespace: protein def: "A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [PMID:9736715, PRO:CNA] comment: Category=family. synonym: "AKT" EXACT [] synonym: "PKB" BROAD [PRO:DNx] synonym: "serine-threonine kinase Akt" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000029394 name: antiviral innate immune response receptor RIG-I namespace: protein def: "A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ATP-dependent RNA helicase DDX58" EXACT [] synonym: "DDX58" RELATED Gene-based [] synonym: "DEAD box protein 58" EXACT [] synonym: "probable ATP-dependent RNA helicase DDX58" EXACT [] synonym: "retinoic acid-inducible gene 1 protein" EXACT [] synonym: "retinoic acid-inducible gene I protein" EXACT [] synonym: "RIG-1" EXACT [] synonym: "RIG-I" EXACT [] synonym: "RIG-I-like receptor 1" EXACT [] synonym: "RIGI" EXACT PRO-short-label [PRO:DNx] synonym: "RLR-1" EXACT [] synonym: "RNA sensor RIG-I" EXACT [] xref: IUPHARobj:2920 is_a: PR:000000001 ! protein [Term] id: PR:000029968 name: somatotropin hormone family member namespace: protein def: "A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide." [PRO:DAN] comment: Category=family. synonym: "fam:GH1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:000030035 name: G-protein coupled receptor namespace: protein def: "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." [IUPHARfam:694, PRO:DAN, Wikipedia:GPCR] comment: Category=family. Classification based on GRAFS system. [PMID:12761335] synonym: "7TM receptor" BROAD [IUPHARfam:694] synonym: "fam:GPCR" EXACT PRO-short-label [PRO:DAN] synonym: "seven-transmembrane receptor" BROAD [IUPHARfam:694] xref: IUPHARfam:694 is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002215 GO:0004930 relationship: RO:0002215 GO:0004930 [Term] id: PR:000030443 name: polyubiquitin-B namespace: protein def: "A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "UBB" EXACT PRO-short-label [PRO:DNx] is_a: PR:000036929 ! tandem-copy polyubiquitin [Term] id: PR:000035716 name: ubiquitin (RPS27A) namespace: protein def: "A ubiquitin-ribosomal protein eS31 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76." [PMID:124018, PRO:CNA] comment: Category=modification. synonym: "RPS27A/Clv:ubiq" EXACT PRO-short-label [PRO:DAN] is_a: PR:000014271 ! ubiquitin-ribosomal protein eS31 fusion protein is_a: PR:000035728 ! ubiquitin relationship: RO:0002353 GO:0016485 [Term] id: PR:000035720 name: ubiquitin (UBC) namespace: protein def: "A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684)." [PRO:CNA] comment: Category=modification. synonym: "UBC/Clv:ubiq" EXACT PRO-short-label [PRO:DAN] is_a: PR:000016963 ! polyubiquitin-C is_a: PR:000035728 ! ubiquitin relationship: RO:0002353 GO:0016485 [Term] id: PR:000035722 name: ubiquitin (UBA52) namespace: protein def: "A ubiquitin-ribosomal protein eL40 fusion protein that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76." [PRO:CNA] comment: Category=modification. synonym: "UBA52/Clv:ubiq" EXACT PRO-short-label [PRO:DAN] is_a: PR:000016954 ! ubiquitin-ribosomal protein eL40 fusion protein is_a: PR:000035728 ! ubiquitin relationship: RO:0002353 GO:0016485 [Term] id: PR:000035726 name: ubiquitin (UBB) namespace: protein def: "A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228)." [PRO:CNA] comment: Category=modification. synonym: "UBB/Clv:ubiq" EXACT PRO-short-label [PRO:DAN] is_a: PR:000030443 ! polyubiquitin-B is_a: PR:000035728 ! ubiquitin relationship: RO:0002353 GO:0016485 [Term] id: PR:000035728 name: ubiquitin namespace: protein def: "A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76." [Pfam:PF00240] comment: Category=union. synonym: "Ubiq" EXACT PRO-short-label [PRO:DAN] is_a: PR:000018264 ! proteolytic cleavage product union_of: PR:000035716 ! ubiquitin (RPS27A) union_of: PR:000035720 ! ubiquitin (UBC) union_of: PR:000035722 ! ubiquitin (UBA52) union_of: PR:000035726 ! ubiquitin (UBB) [Term] id: PR:000036194 name: eukaryotic protein namespace: protein def: "A protein that is encoded in the genome of some Eukaryota." [PRO:DAN] synonym: "Eukaryota protein" EXACT [PRO:DAN] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: RO:0002160 NCBITaxon:2759 relationship: RO:0002160 NCBITaxon:2759 [Term] id: PR:000036929 name: tandem-copy polyubiquitin namespace: protein def: "A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain." [PRO:DAN] comment: Category=family. synonym: "fam:tandemUb" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000037070 name: phosphoprotein namespace: protein def: "A protein that includes at least one phosphorylated residue." [PRO:DAN] comment: Category=modification. synonym: "phosphorylated protein" EXACT [PRO:DAN] synonym: "Prot/PhosRes+" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: BFO:0000051 MOD:00696 relationship: BFO:0000051 MOD:00696 [Term] id: PR:000044630 name: corticotropin-releasing factor receptor namespace: protein def: "A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:19 is_a: PR:000001095 ! secretin-like G-protein coupled receptor [Term] id: PR:000044631 name: adrenoceptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:4 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044637 name: calcitonin receptor protein namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:11 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044643 name: complement peptide receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:5 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044813 name: glycoprotein hormone beta chain namespace: protein def: "A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges." [Pfam:PF00007, PRO:CNA] comment: Category=family. is_a: PR:000000001 ! protein [Term] id: PR:000045358 name: insulin family protein namespace: protein def: "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." [PRO:DAN] comment: Category=family. synonym: "fam:INS" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000049989 name: glucagon-like receptor namespace: protein def: "A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. synonym: "glucagon receptor" BROAD [IUPHARfam:29, PRO:DAN] xref: IUPHARfam:29 is_a: PR:000001095 ! secretin-like G-protein coupled receptor [Term] id: PR:000049994 name: histamine receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:33 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000049997 name: leukotriene receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] comment: Category=family. xref: IUPHARfam:35 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000050025 name: angiotensinogenase namespace: protein def: "A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN] comment: Category=family. synonym: "fam:angiotensinogenase" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000050029 name: thyrotropin-releasing hormone receptor namespace: protein def: "A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity." [GO:0004997, PRO:XQ] comment: Category=family. xref: IUPHARfam:63 is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor intersection_of: PR:000001094 ! rhodopsin-like G-protein coupled receptor intersection_of: RO:0002215 GO:0004997 relationship: RO:0002215 GO:0004997 [Term] id: PR:000050043 name: lymphotoxin namespace: protein def: "A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof." [PRO:DAN] comment: Category=family. Requested by=CRAFT. synonym: "fam:LT" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000033 ! tumor necrosis factor, TNF-like [Term] id: PR:000060228 name: monoubiquitin namespace: protein def: "A ubiquitin that is a monomer." [PRO:DAN] comment: Category=polymer. Requested by=Reactome. synonym: "monoUbiq" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000035728 ! ubiquitin intersection_of: has_constituent_monomer PR:000035728 {cardinality="1"} ! ubiquitin relationship: has_constituent_monomer PR:000035728 {cardinality="1"} ! ubiquitin [Term] id: PR:000064867 name: protein-containing molecular entity namespace: protein def: "A molecular entity that minimally consists of a protein." [PRO:DAN] comment: Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050565). synonym: "protein" NARROW [PRO:DAN] synonym: "protein aggregate" NARROW [PRO:DAN] synonym: "protein complex" NARROW [PRO:DAN] synonym: "protein-containing complex" NARROW [PRO:DAN] is_a: CHEBI:23367 intersection_of: CHEBI:23367 intersection_of: BFO:0000051 PR:000000001 ! protein relationship: BFO:0000051 PR:000000001 ! protein