{ "summary": { "current": { "release_date": "2024-11-24", "valid_terms": 40583, "obsolete_terms": 7347, "merged_terms": 2436, "biological_process_terms": 26412, "molecular_function_terms": 10147, "cellular_component_terms": 4024, "meta_statements": 276911, "cross_references": 23667, "terms_relations": 81213 }, "previous": { "release_date": "2024-11-03", "valid_terms": 40635, "obsolete_terms": 7286, "merged_terms": 2436, "biological_process_terms": 26467, "molecular_function_terms": 10146, "cellular_component_terms": 4022, "meta_statements": 277271, "cross_references": 23657, "terms_relations": 81335 }, "changes": { "created_terms": 9, "valid_terms": -52, "obsolete_terms": 65, "merged_terms": 0, "biological_process_terms": -55, "molecular_function_terms": 1, "cellular_component_terms": 2, "meta_statements": 234, "meta_statements_by_term": 149, "cross_references": 133, "cross_references_by_term": 77, "relations": 156, "relations_by_term": 141 } }, "detailed_changes": { "created_terms": { "biological_process": [ { "id": "GO:0014000", "name": "morula development" }, { "id": "GO:0140001", "name": "morula formation" }, { "id": "GO:0160221", "name": "Rho-activating G protein-coupled receptor signaling pathway" } ], "molecular_function": [ { "id": "GO:0120531", "name": "prenyl diphosphate synthase activity" }, { "id": "GO:0160220", "name": "D-alanine-(R)-lactate ligase activity" }, { "id": "GO:0160222", "name": "D-alanine-D-serine ligase activity" } ], "cellular_component": [ { "id": "GO:0151001", "name": "tuft" }, { "id": "GO:0160219", "name": "cortical endoplasmic reticulum membrane" }, { "id": "GO:0160223", "name": "pyrenoid tubule" } ] }, "obsolete_terms": { "biological_process": [ { "id": "GO:0006025", "name": "galactosaminoglycan biosynthetic process" }, { "id": "GO:0006028", "name": "galactosaminoglycan catabolic process" }, { "id": "GO:0006880", "name": "intracellular sequestering of iron ion" }, { "id": "GO:0006881", "name": "extracellular sequestering of iron ion" }, { "id": "GO:0007253", "name": "cytoplasmic sequestering of NF-kappaB" }, { "id": "GO:0009689", "name": "induction of phytoalexin biosynthetic process" }, { "id": "GO:0019048", "name": "modulation by virus of host process" }, { "id": "GO:0019049", "name": "virus-mediated perturbation of host defense response" }, { "id": "GO:0019054", "name": "modulation by virus of host cellular process" }, { "id": "GO:0019325", "name": "anaerobic fructose catabolic process" }, { "id": "GO:0019463", "name": "glycine catabolic process to creatine" }, { "id": "GO:0019576", "name": "aerobic fructose catabolic process" }, { "id": "GO:0032119", "name": "sequestering of zinc ion" }, { "id": "GO:0034053", "name": "symbiont-mediated perturbation of host defense-related programmed cell death" }, { "id": "GO:0034054", "name": "symbiont-mediated suppression of host defense-related programmed cell death" }, { "id": "GO:0036167", "name": "phenotypic switching in response to host" }, { "id": "GO:0039501", "name": "suppression by virus of host type I interferon production" }, { "id": "GO:0039519", "name": "modulation by virus of host autophagy" }, { "id": "GO:0039521", "name": "suppression by virus of host autophagy" }, { "id": "GO:0039637", "name": "catabolism by virus of host DNA" }, { "id": "GO:0042137", "name": "sequestering of neurotransmitter" }, { "id": "GO:0042989", "name": "sequestering of actin monomers" }, { "id": "GO:0042994", "name": "cytoplasmic sequestering of transcription factor" }, { "id": "GO:0044418", "name": "translocation of DNA into host" }, { "id": "GO:0044501", "name": "perturbation of signal transduction in another organism" }, { "id": "GO:0044831", "name": "modulation by virus of host cytokine production" }, { "id": "GO:0044833", "name": "modulation by virus of host protein transport" }, { "id": "GO:0044863", "name": "modulation by virus of host cell division" }, { "id": "GO:0044864", "name": "positive regulation by virus of host cell division" }, { "id": "GO:0044869", "name": "negative regulation by host of viral exo-alpha-sialidase activity" }, { "id": "GO:0046350", "name": "galactosaminoglycan metabolic process" }, { "id": "GO:0046774", "name": "suppression by virus of host intracellular interferon activity" }, { "id": "GO:0046775", "name": "suppression by virus of host cytokine production" }, { "id": "GO:0050788", "name": "sequestering of mercury" }, { "id": "GO:0051220", "name": "cytoplasmic sequestering of protein" }, { "id": "GO:0051238", "name": "sequestering of metal ion" }, { "id": "GO:0052089", "name": "modulation by symbiont of host salicylic acid-mediated defense response" }, { "id": "GO:0052173", "name": "response to defenses of other organism" }, { "id": "GO:0052318", "name": "regulation of phytoalexin metabolic process" }, { "id": "GO:0052319", "name": "regulation of phytoalexin biosynthetic process" }, { "id": "GO:0052320", "name": "positive regulation of phytoalexin metabolic process" }, { "id": "GO:0052321", "name": "negative regulation of phytoalexin metabolic process" }, { "id": "GO:0052323", "name": "negative regulation of phytoalexin biosynthetic process" }, { "id": "GO:0052403", "name": "negative regulation by host of symbiont catalytic activity" }, { "id": "GO:0052422", "name": "modulation by host of symbiont catalytic activity" }, { "id": "GO:0060858", "name": "vesicle-mediated transport involved in floral organ abscission" }, { "id": "GO:0075528", "name": "perturbation by virus of host immune response" }, { "id": "GO:0097577", "name": "sequestering of iron ion" }, { "id": "GO:0097578", "name": "sequestering of copper ion" }, { "id": "GO:0097579", "name": "extracellular sequestering of copper ion" }, { "id": "GO:0097580", "name": "intracellular sequestering of copper ion" }, { "id": "GO:0140133", "name": "symbiont-mediated suppression of host cytokine production" }, { "id": "GO:0141088", "name": "symbiont-mediated activation of host autophagy" }, { "id": "GO:0141132", "name": "defense response to host" }, { "id": "GO:1901182", "name": "regulation of camalexin biosynthetic process" }, { "id": "GO:1903652", "name": "modulation by virus of host cytoplasmic transport" }, { "id": "GO:1990659", "name": "sequestering of manganese ion" }, { "id": "GO:1990969", "name": "modulation by host of viral RNA-binding transcription factor activity" } ], "molecular_function": [ { "id": "GO:0010012", "name": "steroid 22-alpha hydroxylase activity" }, { "id": "GO:0030374", "name": "nuclear receptor coactivator activity" }, { "id": "GO:0046537", "name": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity" }, { "id": "GO:0046538", "name": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity" }, { "id": "GO:0052850", "name": "NADPH-dependent dihydrocurcumin reductase activity" }, { "id": "GO:0140536", "name": "nuclear receptor corepressor activity" } ], "cellular_component": [ { "id": "GO:0099053", "name": "activating signal cointegrator 1 complex" } ] }, "merged_terms": {}, "meta_statements": { "molecular_function": [ { "id": "GO:0000246", "name": "Delta24(24-1) sterol reductase activity", "changes": { "name": { "current": "Delta24(24-1) sterol reductase activity", "previous": "delta24(24-1) sterol reductase activity" } } }, { "id": "GO:0003707", "name": "nuclear steroid receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:14708019]", "previous": "\"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.\" [GOC:signaling, PMID:14708019]" } } }, { "id": "GO:0004111", "name": "creatine kinase activity", "changes": { "comment": { "current": "Note that this term has a MetaCyc pathway reference as the pathway only has a single step.", "previous": "N/A" } } }, { "id": "GO:0004161", "name": "dimethylallyltranstransferase activity", "changes": { "synonyms": { "current": [ "\"(2E,6E)-farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyltransferase activity\" EXACT []", "\"diprenyltransferase activity\" RELATED [EC:2.5.1.1]", "\"DMAPP:IPP-dimethylallyltransferase activity\" RELATED [EC:2.5.1.1]", "\"geranyl diphosphate synthase activity\" EXACT []", "\"geranyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"geranyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"geranyl-diphosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"trans-farnesyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]" ], "previous": [ "\"(2E,6E)-farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyltransferase activity\" EXACT []", "\"diprenyltransferase activity\" RELATED [EC:2.5.1.1]", "\"DMAPP:IPP-dimethylallyltransferase activity\" RELATED [EC:2.5.1.1]", "\"geranyl diphosphate synthase\" EXACT []", "\"geranyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"geranyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"geranyl-diphosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"trans-farnesyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]" ] } } }, { "id": "GO:0004177", "name": "aminopeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.\" [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]", "previous": "\"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.\" [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]" } } }, { "id": "GO:0004230", "name": "glutamyl aminopeptidase activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "glutamyl aminopeptidase activity", "previous": "obsolete glutamyl aminopeptidase activity" }, "definition": { "current": "\"Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.\" [EC:3.4.11.7]", "previous": "\"OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.\" [EC:3.4.11.7]" }, "comment": { "current": "N/A", "previous": "This term was made obsolete because it represents a gene product." }, "synonyms": { "current": [ "\"aminopeptidase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A2\" RELATED [EC:3.4.11.7]", "\"antigen BP-1/6C3 of mouse B lymphocytes\" RELATED [EC:3.4.11.7]", "\"aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"Ca2+-activated glutamate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"glutamyl peptidase activity\" RELATED [EC:3.4.11.7]", "\"L-aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"membrane aminopeptidase II\" RELATED [EC:3.4.11.7]" ], "previous": [ "\"aminopeptidase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A2\" RELATED [EC:3.4.11.7]", "\"antigen BP-1/6C3 of mouse B lymphocytes\" RELATED [EC:3.4.11.7]", "\"aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"Ca2+-activated glutamate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"glutamyl aminopeptidase activity\" EXACT []", "\"glutamyl peptidase activity\" RELATED [EC:3.4.11.7]", "\"L-aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"membrane aminopeptidase II\" RELATED [EC:3.4.11.7]" ] } } }, { "id": "GO:0004311", "name": "geranylgeranyl diphosphate synthase activity", "changes": { "name": { "current": "geranylgeranyl diphosphate synthase activity", "previous": "farnesyltranstransferase activity" }, "synonyms": { "current": [ "\"farnesyltranstransferase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthetase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-diphosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-PP synthetase activity\" EXACT [EC:2.5.1.29]", "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]" ], "previous": [ "\"geranylgeranyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthetase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-diphosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-PP synthetase activity\" EXACT [EC:2.5.1.29]", "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]" ] } } }, { "id": "GO:0004337", "name": "(2E,6E)-farnesyl diphosphate synthase activity", "changes": { "name": { "current": "(2E,6E)-farnesyl diphosphate synthase activity", "previous": "geranyltranstransferase activity" }, "synonyms": { "current": [ "\"farnesyl diphosphate synthase activity\" EXACT []", "\"farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"farnesyl pyrophosphate synthetase activity\" EXACT []", "\"farnesyl-diphosphate synthase activity\" EXACT []", "\"farnesylpyrophosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"FPP synthetase activity\" RELATED [EC:2.5.1.10]", "\"geranyl transferase I\" RELATED [EC:2.5.1.10]", "\"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltranstransferase activity\" EXACT [EC:2.5.1.10]" ], "previous": [ "\"farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"farnesyl pyrophosphate synthetase activity\" EXACT []", "\"farnesyl-diphosphate synthase activity\" EXACT []", "\"farnesylpyrophosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"FPP synthetase activity\" RELATED [EC:2.5.1.10]", "\"geranyl transferase I\" RELATED [EC:2.5.1.10]", "\"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltransferase activity\" RELATED [EC:2.5.1.10]" ] } } }, { "id": "GO:0004619", "name": "phosphoglycerate mutase activity", "changes": { "synonyms": { "current": [ "\"2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity\" NARROW []", "\"2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity\" NARROW []", "\"D-phosphoglycerate 2,3-phosphomutase activity\" RELATED []", "\"PGA mutase activity\" RELATED []", "\"PGAM activity\" RELATED []", "\"PGM\" EXACT []", "\"phosphoglycerate phosphomutase activity\" RELATED []", "\"phosphoglyceromutase activity\" RELATED []" ], "previous": [ "\"D-phosphoglycerate 2,3-phosphomutase activity\" RELATED []", "\"PGA mutase activity\" RELATED []", "\"PGAM activity\" RELATED []", "\"PGM\" EXACT []", "\"phosphoglycerate phosphomutase activity\" RELATED []", "\"phosphoglyceromutase activity\" RELATED []" ] } } }, { "id": "GO:0004779", "name": "sulfate adenylyltransferase activity", "changes": { "definition": { "current": "\"Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.\" [GOC:mah]", "previous": "\"Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.\" [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]" } } }, { "id": "GO:0004883", "name": "nuclear glucocorticoid receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:17689856, PMID:20920967]", "previous": "\"Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.\" [GOC:signaling, PMID:17689856, PMID:20920967]" } } }, { "id": "GO:0008241", "name": "peptidyl-dipeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the release of C-terminal dipeptides from a polypeptide chain.\" [EC:3.4.15.-, GOC:mb]", "previous": "\"Catalysis of the release of C-terminal dipeptides from a polypeptide chain.\" [GOC:mb]" } } }, { "id": "GO:0008412", "name": "4-hydroxybenzoate polyprenyltransferase activity", "changes": { "synonyms": { "current": [ "\"4-HB polyprenyltransferase activity\" EXACT []", "\"4-hydroxybenzoate nonaprenyltransferase activity\" NARROW [EC:2.5.1.39]", "\"para-hydroxybenzoate transferase activity\" EXACT []", "\"para-hydroxybenzoate-polyprenyl diphosphate transferase activity\" EXACT []", "\"para-hydroxybenzoate:polyprenyltransferase activity\" EXACT []", "\"PHB polyprenyl diphosphate transferase activity\" EXACT []" ], "previous": [ "\"4-HB polyprenyltransferase activity\" EXACT []", "\"para-hydroxybenzoate transferase activity\" EXACT []", "\"para-hydroxybenzoate-polyprenyl diphosphate transferase activity\" EXACT []", "\"para-hydroxybenzoate:polyprenyltransferase activity\" EXACT []", "\"PHB polyprenyl diphosphate transferase activity\" EXACT []" ] } } }, { "id": "GO:0008709", "name": "cholate 7-alpha-dehydrogenase (NAD+) activity", "changes": { "name": { "current": "cholate 7-alpha-dehydrogenase (NAD+) activity", "previous": "cholate 7-alpha-dehydrogenase activity" } } }, { "id": "GO:0008834", "name": "ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity", "changes": { "name": { "current": "ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity", "previous": "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" }, "synonyms": { "current": [ "\"bactoprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenylcistransferase activity\" EXACT []", "\"di-trans,poly-cis-undecaprenyl-diphosphate synthase activity\" EXACT [EC:2.5.1.31]", "\"undecaprenyl diphosphate synthase activity\" EXACT []", "\"undecaprenyl diphosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"UPP synthetase activity\" RELATED [EC:2.5.1.31]" ], "previous": [ "\"bactoprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenylcistransferase activity\" EXACT []", "\"undecaprenyl diphosphate synthase activity\" EXACT []", "\"undecaprenyl diphosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"UPP synthetase activity\" RELATED [EC:2.5.1.31]" ] } } }, { "id": "GO:0010176", "name": "homogentisate phytyltransferase activity", "changes": { "synonyms": { "current": [ "\"HPT activity\" EXACT [EC:2.5.1.115]" ], "previous": "N/A" } } }, { "id": "GO:0010356", "name": "homogentisate geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"HGGT activity\" EXACT [EC:2.5.1.116]", "\"homogentisate geranylgeranyl transferase activity\" EXACT [PMID:21223386]" ], "previous": [ "\"homogentisate geranylgeranyl transferase activity\" EXACT [PMID:21223386]" ] } } }, { "id": "GO:0010357", "name": "homogentisate solanesyltransferase activity", "changes": { "synonyms": { "current": [ "\"homogentisate solanyltransferase activity\" EXACT []", "\"HST activity\" EXACT [EC:2.5.1.117]" ], "previous": [ "\"homogentisate solanyltransferase activity\" EXACT []" ] } } }, { "id": "GO:0016172", "name": "antifreeze activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "antifreeze activity", "previous": "obsolete antifreeze activity" }, "definition": { "current": "\"Inhibits the growth and recrystallization of ice crystals, thereby lowering the freezing point of water and preventing cellular damage at subzero temperatures. This activity is observed in various cold-adapted organisms, including certain fish, insects, and plants, and contributes to survival in extreme cold environments by stabilizing supercooled liquid states.\" [GOC:cjm, PMID:33317024]", "previous": "\"OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures.\" [GOC:jl]" }, "comment": { "current": "Note that this term was reinstated from obsolete.", "previous": "This term was made obsolete because it refers to a biological process." }, "synonyms": { "current": "N/A", "previous": [ "\"antifreeze activity\" EXACT []" ] } } }, { "id": "GO:0016285", "name": "alanyl aminopeptidase activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "alanyl aminopeptidase activity", "previous": "obsolete cytosol alanyl aminopeptidase activity" }, "definition": { "current": "\"Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.\" [EC:3.4.11.14]", "previous": "\"OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.\" [EC:3.4.11.14]" }, "comment": { "current": "N/A", "previous": "This term was made obsolete because it represents a gene product and refers to cellular component information." }, "synonyms": { "current": [ "\"aminopolypeptidase activity\" BROAD [EC:3.4.11.14]", "\"arylamidase activity\" NARROW [EC:3.4.11.14]", "\"cytosol alanyl aminopeptidase activity\" EXACT []", "\"cytosol aminopeptidase III activity\" NARROW [EC:3.4.11.14]", "\"human liver aminopeptidase\" NARROW [EC:3.4.11.14]", "\"liver aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"membrane alanine aminopeptidase\" NARROW []", "\"membrane alanyl aminopeptidase\" NARROW []", "\"puromycin-sensitive aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"soluble alanyl aminopeptidase activity\" RELATED [EC:3.4.11.14]", "\"thiol-activated aminopeptidase activity\" RELATED [EC:3.4.11.14]" ], "previous": [ "\"aminopolypeptidase activity\" RELATED [EC:3.4.11.14]", "\"arylamidase activity\" NARROW [EC:3.4.11.14]", "\"cytosol alanyl aminopeptidase activity\" EXACT []", "\"cytosol aminopeptidase III activity\" NARROW [EC:3.4.11.14]", "\"human liver aminopeptidase\" NARROW [EC:3.4.11.14]", "\"liver aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"puromycin-sensitive aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"soluble alanyl aminopeptidase activity\" RELATED [EC:3.4.11.14]", "\"thiol-activated aminopeptidase activity\" RELATED [EC:3.4.11.14]" ] } } }, { "id": "GO:0016664", "name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "changes": { "definition": { "current": "\"Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein.\" [EC:1.7.7.-]", "previous": "\"Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein.\" [GOC:jl]" } } }, { "id": "GO:0016805", "name": "dipeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the hydrolysis of a dipeptide.\" [EC:3.4.13.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]", "previous": "\"Catalysis of the hydrolysis of a dipeptide.\" [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]" } } }, { "id": "GO:0019833", "name": "ice nucleation activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "ice nucleation activity", "previous": "obsolete ice nucleation activity" }, "definition": { "current": "\"Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees Celsius) to protect the organism from damage by intracellular ice formation. This process is commonly found in certain bacteria, such as Pseudomonas syringae, and plays roles in environmental adaptation and plant pathogenesis.\" [GOC:cjm, PMID:35551271, UniProt:KW-0387]", "previous": "\"OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins" }, "comment": { "current": "Note that this term was reinstated from obsolete.", "previous": "This term was made obsolete because it represents a biological process." }, "synonyms": { "current": "N/A", "previous": [ "\"ice nucleation activity\" EXACT []" ] } } }, { "id": "GO:0030284", "name": "nuclear estrogen receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by estrogen binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:17615392]", "previous": "\"Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.\" [GOC:signaling, PMID:17615392]" } } }, { "id": "GO:0031963", "name": "nuclear cortisol receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by cortisol binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:mah, PMID:12511169]", "previous": "\"Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.\" [GOC:mah, PMID:12511169]" } } }, { "id": "GO:0033782", "name": "24S-hydroxycholesterol 7alpha-hydroxylase activity", "changes": { "name": { "current": "24S-hydroxycholesterol 7alpha-hydroxylase activity", "previous": "24-hydroxycholesterol 7alpha-hydroxylase activity" }, "synonyms": { "current": [ "\"24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity\" RELATED []", "\"24-hydroxycholesterol 7alpha-hydroxylase activity\" BROAD []", "\"24-hydroxycholesterol 7alpha-monooxygenase activity\" RELATED [EC:1.14.14.26]" ], "previous": [ "\"24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity\" RELATED []", "\"24-hydroxycholesterol 7alpha-monooxygenase activity\" RELATED [EC:1.14.14.26]" ] } } }, { "id": "GO:0036423", "name": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "changes": { "synonyms": { "current": [ "\"hexaprenyl diphosphate synthase activity\" BROAD [EC:2.5.1.83]", "\"hexaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.83]", "\"HexPS activity\" EXACT [EC:2.5.1.83]" ], "previous": [ "\"hexaprenyl diphosphate synthase activity\" BROAD [EC:2.5.1.83]", "\"hexaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.83]" ] } } }, { "id": "GO:0038186", "name": "bile acid nuclear receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by a bile acid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [PMID:32480317, PMID:35415765, PMID:36409000]", "previous": "\"A DNA-binding transcription factor activity regulated by binding to a bile acid that modulates the transcription of specific gene sets transcribed by RNA polymerase II.\" [PMID:32480317, PMID:35415765, PMID:36409000]" } } }, { "id": "GO:0044687", "name": "geranylfarnesyl diphosphate synthase activity", "changes": { "synonyms": { "current": [ "\"FGPP synthase activity\" EXACT [EC:2.5.1.81]" ], "previous": "N/A" } } }, { "id": "GO:0045547", "name": "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "changes": { "name": { "current": "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "previous": "dehydrodolichyl diphosphate synthase activity" }, "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate.\" [PMID:9858571]" }, "synonyms": { "current": [ "\"dehydrodolichyl diphosphate synthase activity\" EXACT [EC:2.5.1.87]" ], "previous": "N/A" } } }, { "id": "GO:0046562", "name": "beta-D-glucose oxidase activity", "changes": { "name": { "current": "beta-D-glucose oxidase activity", "previous": "glucose oxidase activity" }, "synonyms": { "current": [ "\"beta-D-glucose:oxygen 1-oxido-reductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:oxygen 1-oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:quinone oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"corylophyline\" RELATED [EC:1.1.3.4]", "\"D-glucose oxidase activity\" RELATED [EC:1.1.3.4]", "\"D-glucose-1-oxidase activity\" RELATED [EC:1.1.3.4]", "\"deoxin-1\" RELATED [EC:1.1.3.4]", "\"glucose aerodehydrogenase activity\" RELATED [EC:1.1.3.4]", "\"glucose oxidase activity\" EXACT []", "\"glucose oxyhydrase activity\" RELATED [EC:1.1.3.4]", "\"GOD activity\" RELATED [EC:1.1.3.4]", "\"microcid\" RELATED [EC:1.1.3.4]", "\"penatin\" RELATED [EC:1.1.3.4]" ], "previous": [ "\"beta-D-glucose oxidase activity\" EXACT []", "\"beta-D-glucose:oxygen 1-oxido-reductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:oxygen 1-oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:quinone oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"corylophyline\" RELATED [EC:1.1.3.4]", "\"D-glucose oxidase activity\" RELATED [EC:1.1.3.4]", "\"D-glucose-1-oxidase activity\" RELATED [EC:1.1.3.4]", "\"deoxin-1\" RELATED [EC:1.1.3.4]", "\"glucose aerodehydrogenase activity\" RELATED [EC:1.1.3.4]", "\"glucose oxyhydrase activity\" RELATED [EC:1.1.3.4]", "\"GOD activity\" RELATED [EC:1.1.3.4]", "\"microcid\" RELATED [EC:1.1.3.4]", "\"penatin\" RELATED [EC:1.1.3.4]" ] } } }, { "id": "GO:0047006", "name": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity", "previous": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity" }, "synonyms": { "current": [ "\"17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity\" EXACT []", "\"20alpha-HSD\" RELATED [EC:1.1.1.149]", "\"20alpha-HSDH\" RELATED [EC:1.1.1.149]", "\"20alpha-hydroxy steroid dehydrogenase activity\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid dehydrogenase\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity\" BROAD [EC:1.1.1.149]" ], "previous": [ "\"20alpha-HSD\" RELATED [EC:1.1.1.149]", "\"20alpha-HSDH\" RELATED [EC:1.1.1.149]", "\"20alpha-hydroxy steroid dehydrogenase activity\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid dehydrogenase\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity\" BROAD [EC:1.1.1.149]" ] } } }, { "id": "GO:0047023", "name": "androsterone dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "androsterone dehydrogenase [NAD(P)+] activity", "previous": "androsterone dehydrogenase activity" } } }, { "id": "GO:0047024", "name": "5-alpha-androstane-3beta,17beta-diol dehydrogenase (NADP+) activity", "changes": { "name": { "current": "5-alpha-androstane-3beta,17beta-diol dehydrogenase (NADP+) activity", "previous": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity" }, "synonyms": { "current": [ "\"3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3-beta-HSD activity\" RELATED [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"3beta,20alpha-hydroxysteroid oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"5alpha-androstane-3beta,17beta-diol dehydrogenase activity\" EXACT []", "\"dehydrogenase, 3beta,20alpha-hydroxy steroid\" BROAD [EC:1.1.1.210]", "\"progesterone reductase activity\" RELATED [EC:1.1.1.210]" ], "previous": [ "\"3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3-beta-HSD activity\" RELATED [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"3beta,20alpha-hydroxysteroid oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"dehydrogenase, 3beta,20alpha-hydroxy steroid\" BROAD [EC:1.1.1.210]", "\"progesterone reductase activity\" RELATED [EC:1.1.1.210]" ] } } }, { "id": "GO:0047044", "name": "androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "changes": { "name": { "current": "androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "previous": "androstan-3-alpha,17-beta-diol dehydrogenase activity" } } }, { "id": "GO:0047294", "name": "phosphoglycerol geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"(S)-3-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]", "\"geranylgeranyl-transferase activity\" RELATED [EC:2.5.1.41]", "\"GGGP synthase activity\" EXACT [EC:2.5.1.41]", "\"GGGPS activity\" EXACT [EC:2.5.1.41]", "\"glycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]" ], "previous": [ "\"(S)-3-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]", "\"geranylgeranyl-transferase activity\" RELATED [EC:2.5.1.41]", "\"glycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]" ] } } }, { "id": "GO:0047295", "name": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"DGGGP synthase activity\" EXACT [EC:2.5.1.42]", "\"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyltransferase II\" RELATED [EC:2.5.1.42]" ], "previous": [ "\"(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyltransferase II\" RELATED [EC:2.5.1.42]" ] } } }, { "id": "GO:0047521", "name": "12-beta-hydroxysteroid dehydrogenase (NADP+) activity", "changes": { "name": { "current": "12-beta-hydroxysteroid dehydrogenase (NADP+) activity", "previous": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity" }, "synonyms": { "current": [ "\"12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity\" BROAD [EC:1.1.1.238]", "\"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity\" BROAD [EC:1.1.1.238]" ], "previous": [ "\"12-beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity\" BROAD [EC:1.1.1.238]" ] } } }, { "id": "GO:0047791", "name": "cucurbitacin Delta23 reductase [NAD(P)H] activity", "changes": { "name": { "current": "cucurbitacin Delta23 reductase [NAD(P)H] activity", "previous": "cucurbitacin delta23-reductase activity" } } }, { "id": "GO:0050613", "name": "Delta14-sterol reductase activity", "changes": { "name": { "current": "Delta14-sterol reductase activity", "previous": "delta14-sterol reductase activity" } } }, { "id": "GO:0050614", "name": "Delta24-sterol reductase activity", "changes": { "name": { "current": "Delta24-sterol reductase activity", "previous": "delta24-sterol reductase activity" } } }, { "id": "GO:0050825", "name": "ice binding", "changes": { "synonyms": { "current": [ "\"ice crystal binding\" EXACT []", "\"ice nucleation inhibitor activity\" RELATED []" ], "previous": [ "\"antifreeze activity\" RELATED []", "\"ice crystal binding\" EXACT []", "\"ice nucleation activity\" RELATED []", "\"ice nucleation inhibitor activity\" RELATED []" ] } } }, { "id": "GO:0051996", "name": "squalene synthase [NAD(P)H] activity", "changes": { "synonyms": { "current": [ "\"farnesyl-diphosphate farnesyltransferase activity\" NARROW [EC:2.5.1.21]", "\"farnesyltransferase activity\" BROAD [EC:2.5.1.21]", "\"presqualene synthase activity\" EXACT [EC:2.5.1.21]", "\"presqualene-diphosphate synthase activity\" EXACT [EC:2.5.1.21]", "\"squalene synthase activity\" EXACT [EC:2.5.1.21]", "\"squalene synthetase activity\" RELATED [EC:2.5.1.21]" ], "previous": [ "\"squalene synthetase activity\" RELATED [EC:2.5.1.21]" ] } } }, { "id": "GO:0052849", "name": "curcumin reductase (NADP+) activity", "changes": { "name": { "current": "curcumin reductase (NADP+) activity", "previous": "NADPH-dependent curcumin reductase activity" }, "synonyms": { "current": [ "\"NADPH-dependent curcumin reductase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0061776", "name": "ATP-dependent topological DNA co-entrapment activity", "changes": { "name": { "current": "ATP-dependent topological DNA co-entrapment activity", "previous": "topological DNA co-entrapment activity" }, "synonyms": { "current": [ "\"ATP-dependent ring closure activity\" EXACT []", "\"topological DNA entrapment activity\" RELATED []" ], "previous": [ "\"topological DNA entrapment activity\" RELATED []" ] } } }, { "id": "GO:0097269", "name": "all-trans-decaprenyl-diphosphate synthase activity", "changes": { "synonyms": { "current": [ "\"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" EXACT []", "\"2-trans,6-trans-farnesyl diphosphate activity\" EXACT []", "\"decaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"decaprenyl-diphosphate synthase activity\" BROAD [EC:2.5.1.91]", "\"polyprenylpyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"terpenoidallyltransferase activity\" BROAD [EC:2.5.1.91]", "\"terpenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"trans-prenyltransferase activity\" BROAD [EC:2.5.1.91]" ], "previous": [ "\"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" EXACT []", "\"2-trans,6-trans-farnesyl diphosphate activity\" EXACT []" ] } } }, { "id": "GO:0098531", "name": "ligand-modulated transcription factor activity", "changes": { "name": { "current": "ligand-modulated transcription factor activity", "previous": "ligand-activated transcription factor activity" }, "synonyms": { "current": [ "\"direct ligand regulated sequence-specific DNA binding transcription factor activity\" EXACT []", "\"ligand-activated transcription factor activity\" NARROW []", "\"transcription factor activity, direct ligand regulated sequence-specific DNA binding\" EXACT []" ], "previous": [ "\"direct ligand regulated sequence-specific DNA binding transcription factor activity\" EXACT []", "\"transcription factor activity, direct ligand regulated sequence-specific DNA binding\" EXACT []" ] } } }, { "id": "GO:0102059", "name": "(2Z,6Z)-farnesyl diphosphate synthase activity", "changes": { "name": { "current": "(2Z,6Z)-farnesyl diphosphate synthase activity", "previous": "2-cis,6-cis-farnesyl pyrophosphate synthase activity" }, "synonyms": { "current": [ "\"2-cis,6-cis-farnesyl pyrophosphate synthase activity\" EXACT []", "\"cis,cis-farnesyl diphosphate synthase activity\" EXACT [EC:2.5.1.92]", "\"neryl-diphosphate:isopentenyl-diphosphate cistransferase activity\" NARROW []", "\"Z,Z-farnesyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.92]", "\"Z,Z-FPP synthase activity\" EXACT [EC:2.5.1.92]", "\"zFPS activity\" EXACT [EC:2.5.1.92]" ], "previous": [ "\"neryl-diphosphate:isopentenyl-diphosphate cistransferase activity\" NARROW []" ] } } }, { "id": "GO:0102175", "name": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase (NAD+) activity", "changes": { "name": { "current": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase (NAD+) activity", "previous": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity" } } }, { "id": "GO:0102191", "name": "3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity", "changes": { "name": { "current": "3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity", "previous": "3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity" }, "synonyms": { "current": [ "\"3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity\" EXACT []", "\"4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity\" EXACT []" ], "previous": [ "\"4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity\" EXACT []" ] } } }, { "id": "GO:0103031", "name": "L-Ala-D/L-Glu epimerase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction:L-alanyl-L-glutamate = L-alanyl-D-glutamate.\" [RHEA:28394]", "previous": "\"Catalysis of the reaction" } } }, { "id": "GO:0106350", "name": "all-trans-octaprenyl-diphosphate synthase activity", "changes": { "name": { "current": "all-trans-octaprenyl-diphosphate synthase activity", "previous": "octaprenyl pyrophosphate synthase activity" }, "synonyms": { "current": [ "\"octaprenyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.90]", "\"terpenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.90]", "\"trans-heptaprenyltranstransferase activity\" EXACT [EC:2.5.1.90]", "\"trans-prenyltransferase activity\" BROAD [EC:2.5.1.90]" ], "previous": "N/A" } } }, { "id": "GO:0141096", "name": "ligand-modulated transcription repressor activity", "changes": { "name": { "current": "ligand-modulated transcription repressor activity", "previous": "ligand-activated transcription repressor activity" }, "synonyms": { "current": [ "\"ligand-activated transcription repressor activity\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0141097", "name": "ligand-modulated transcription activator activity", "changes": { "name": { "current": "ligand-modulated transcription activator activity", "previous": "ligand-activated transcription activator activity" }, "synonyms": { "current": [ "\"ligand-activated transcription activator activity\" NARROW []" ], "previous": "N/A" } } } ], "biological_process": [ { "id": "GO:0001824", "name": "blastocyst development", "changes": { "definition": { "current": "\"The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "previous": "\"The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]" }, "synonyms": { "current": [ "\"blastula development\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001825", "name": "blastocyst formation", "changes": { "synonyms": { "current": [ "\"blastula formation\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001832", "name": "blastocyst growth", "changes": { "synonyms": { "current": [ "\"blastula growth\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001835", "name": "blastocyst hatching", "changes": { "synonyms": { "current": [ "\"blastula hatching\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0006601", "name": "creatine biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.\" [GOC:mah, MetaCyc:GLYCGREAT-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.\" [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]" } } }, { "id": "GO:0006675", "name": "mannosyl-inositol phosphorylceramide metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.\" [GOC:ai]", "previous": "\"The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.\" [GOC:ai, MetaCyc:MIPC]" } } }, { "id": "GO:0008153", "name": "4-aminobenzoate biosynthetic process", "changes": { "name": { "current": "4-aminobenzoate biosynthetic process", "previous": "para-aminobenzoic acid biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]", "previous": "\"The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]" }, "synonyms": { "current": [ "\"4-aminobenzoic acid biosynthesis\" EXACT []", "\"4-aminobenzoic acid biosynthetic process\" EXACT []", "\"p-aminobenzoic acid biosynthesis\" EXACT []", "\"p-aminobenzoic acid biosynthetic process\" EXACT []", "\"PABA biosynthesis\" EXACT []", "\"PABA biosynthetic process\" EXACT []", "\"para-aminobenzoic acid anabolism\" EXACT []", "\"para-aminobenzoic acid biosynthesis\" EXACT []", "\"para-aminobenzoic acid biosynthetic process\" EXACT []", "\"para-aminobenzoic acid formation\" EXACT []", "\"para-aminobenzoic acid synthesis\" EXACT []", "\"vitamin Bx biosynthesis\" EXACT []", "\"vitamin Bx biosynthetic process\" EXACT []" ], "previous": [ "\"4-aminobenzoic acid biosynthesis\" EXACT []", "\"4-aminobenzoic acid biosynthetic process\" EXACT []", "\"p-aminobenzoic acid biosynthesis\" EXACT []", "\"p-aminobenzoic acid biosynthetic process\" EXACT []", "\"PABA biosynthesis\" EXACT []", "\"PABA biosynthetic process\" EXACT []", "\"para-aminobenzoic acid anabolism\" EXACT []", "\"para-aminobenzoic acid biosynthesis\" EXACT []", "\"para-aminobenzoic acid formation\" EXACT []", "\"para-aminobenzoic acid synthesis\" EXACT []", "\"vitamin Bx biosynthesis\" EXACT []", "\"vitamin Bx biosynthetic process\" EXACT []" ] } } }, { "id": "GO:0009626", "name": "plant-type hypersensitive response", "changes": { "comment": { "current": "Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185.", "previous": "Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'." } } }, { "id": "GO:0010134", "name": "sulfate assimilation via adenylyl sulfate reduction", "changes": { "definition": { "current": "\"The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase.\" [MetaCyc:SULFMETII-PWY]", "previous": "\"The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase.\" [EC:1.8.99.2]" } } }, { "id": "GO:0018868", "name": "2-aminobenzenesulfonate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [UM-BBD_pathwayID:abs]" } } }, { "id": "GO:0018873", "name": "atrazine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide.\" [UM-BBD_pathwayID:atr]" } } }, { "id": "GO:0018882", "name": "(+)-camphor metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed.\" [UM-BBD_pathwayID:cam]" } } }, { "id": "GO:0018901", "name": "2,4-dichlorophenoxyacetic acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [UM-BBD_pathwayID:2\\,4d]" } } }, { "id": "GO:0018952", "name": "parathion metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [UM-BBD_pathwayID:pthn]" } } }, { "id": "GO:0018970", "name": "toluene metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.\" [UM-BBD_pathwayID:tol]" } } }, { "id": "GO:0018983", "name": "Z-phenylacetaldoxime metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.\" [UM-BBD_pathwayID:pao]", "previous": "\"The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.\" [UM-BBD_pathwayID:car]" } } }, { "id": "GO:0019087", "name": "symbiont-mediated transformation of host cell", "changes": { "name": { "current": "symbiont-mediated transformation of host cell", "previous": "transformation of host cell by virus" }, "definition": { "current": "\"A symbiont-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. Usually mediated by viruses.\" [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]", "previous": "\"A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication.\" [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]" }, "synonyms": { "current": [ "\"host cell immortalization\" EXACT []", "\"host cell transformation\" EXACT []", "\"immortalization of host cell\" EXACT []", "\"immortalization of host cell by virus\" RELATED []", "\"transformation of host cell\" EXACT []", "\"transformation of host cell by virus\" EXACT []", "\"viral immortalization\" EXACT []", "\"viral transformation\" EXACT []", "\"viral transformation of host cell\" EXACT []", "\"virus-mediated transformation of host cell\" RELATED []" ], "previous": [ "\"host cell immortalization\" EXACT []", "\"host cell transformation\" EXACT []", "\"immortalization of host cell\" EXACT []", "\"immortalization of host cell by virus\" RELATED []", "\"transformation of host cell\" EXACT []", "\"viral immortalization\" EXACT []", "\"viral transformation\" EXACT []", "\"viral transformation of host cell\" EXACT []" ] } } }, { "id": "GO:0019329", "name": "ammonia oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons.\" [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242]" } } }, { "id": "GO:0019339", "name": "parathion catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [MetaCyc:PARATHION-DEGRADATION-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [UM-BBD_pathwayID:pthn]" } } }, { "id": "GO:0019381", "name": "atrazine catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.\" [GOC:jl, MetaCyc:PWY-5724]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.\" [GOC:jl, UM-BBD_pathwayID:atr]" } } }, { "id": "GO:0019383", "name": "(+)-camphor catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone.\" [MetaCyc:P601-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone.\" [UM-BBD_pathwayID:cam]" } } }, { "id": "GO:0019417", "name": "sulfur oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.\" [GOC:jl]", "previous": "\"The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.\" [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]" } } }, { "id": "GO:0019434", "name": "sophorosyloxydocosanoate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon.\" [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE]" } } }, { "id": "GO:0019490", "name": "2-aminobenzenesulfonate desulfonation", "changes": { "definition": { "current": "\"The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [MetaCyc:2ASDEG-PWY]", "previous": "\"The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [UM-BBD_pathwayID:abs]" } } }, { "id": "GO:0019517", "name": "L-threonine catabolic process to D-lactate", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate.\" [GOC:bf, GOC:jl, MetaCyc:THRDLCTCAT-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate.\" [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY]" } } }, { "id": "GO:0019662", "name": "non-glycolytic fermentation", "changes": { "definition": { "current": "\"Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.\" [GOC:jl]", "previous": "\"Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.\" [GOC:jl, MetaCyc:Fermentation]" } } }, { "id": "GO:0019665", "name": "anaerobic amino acid catabolic process", "changes": { "definition": { "current": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP.\" [GOC:curators, GOC:jl]", "previous": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP.\" [GOC:curators, GOC:jl, MetaCyc:Fermentation]" } } }, { "id": "GO:0033108", "name": "mitochondrial respiratory chain complex assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures.\" [GOC:mah]", "previous": "\"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.\" [GOC:mah]" } } }, { "id": "GO:0033302", "name": "quercetin O-glucoside metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving O-glucosylated derivatives of quercetin.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving O-glucosylated derivatives of quercetin.\" [GOC:mah, MetaCyc:PWY-5321]" } } }, { "id": "GO:0033321", "name": "homomethionine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]" } } }, { "id": "GO:0033322", "name": "L-homomethionine biosynthetic process", "changes": { "name": { "current": "L-homomethionine biosynthetic process", "previous": "homomethionine biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-homomethionine, a non-protein amino acid synthesized from L-methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]", "previous": "\"The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]" }, "synonyms": { "current": [ "\"homomethionine anabolism\" EXACT []", "\"homomethionine biosynthesis\" EXACT []", "\"homomethionine biosynthetic process\" EXACT []", "\"homomethionine formation\" EXACT []", "\"homomethionine synthesis\" EXACT []" ], "previous": [ "\"homomethionine anabolism\" EXACT []", "\"homomethionine biosynthesis\" EXACT []", "\"homomethionine formation\" EXACT []", "\"homomethionine synthesis\" EXACT []" ] } } }, { "id": "GO:0033329", "name": "kaempferol O-glucoside metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol.\" [GOC:mah, MetaCyc:PWY-5320]" } } }, { "id": "GO:0033331", "name": "ent-kaurene metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.\" [GOC:mah, PMID:17064690]", "previous": "\"The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.\" [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]" } } }, { "id": "GO:0033359", "name": "lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.\" [GOC:mah, MetaCyc:DAPLYSINESYN-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.\" [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-]" } } }, { "id": "GO:0033383", "name": "geranyl diphosphate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes.\" [GOC:mah, MetaCyc:PWY-5122]" } } }, { "id": "GO:0033385", "name": "geranylgeranyl diphosphate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.\" [GOC:mah, MetaCyc:PWY-5120]" } } }, { "id": "GO:0033386", "name": "geranylgeranyl diphosphate biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.\" [GOC:mah, MetaCyc:PWY-5120]" } } }, { "id": "GO:0033387", "name": "putrescine biosynthetic process from arginine, via ornithine", "changes": { "name": { "current": "putrescine biosynthetic process from arginine, via ornithine", "previous": "putrescine biosynthetic process from ornithine" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine, via decarboxylation of ornithine.\" [GOC:mah, MetaCyc:PWY-46]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine.\" [GOC:mah, MetaCyc:PWY-46]" }, "synonyms": { "current": [ "\"putrescine anabolism from ornithine\" EXACT []", "\"putrescine biosynthesis from ornithine\" EXACT []", "\"putrescine biosynthetic process from ornithine\" EXACT []", "\"putrescine formation from ornithine\" EXACT []", "\"putrescine synthesis from ornithine\" EXACT []" ], "previous": [ "\"putrescine anabolism from ornithine\" EXACT []", "\"putrescine biosynthesis from ornithine\" EXACT []", "\"putrescine formation from ornithine\" EXACT []", "\"putrescine synthesis from ornithine\" EXACT []" ] } } }, { "id": "GO:0033388", "name": "putrescine biosynthetic process from arginine", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine.\" [GOC:mah, MetaCyc:PWY-46]" } } }, { "id": "GO:0033389", "name": "putrescine biosynthetic process from arginine, via agmatine", "changes": { "name": { "current": "putrescine biosynthetic process from arginine, via agmatine", "previous": "putrescine biosynthetic process from arginine, using agmatinase" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine via agmatine.\" [GOC:mah, MetaCyc:PWY-40]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step.\" [GOC:mah, MetaCyc:PWY-40]" }, "synonyms": { "current": [ "\"putrescine anabolism from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthesis from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthetic process from arginine, using agmatinase\" EXACT []", "\"putrescine formation from arginine, using agmatinase\" EXACT []", "\"putrescine synthesis from arginine, using agmatinase\" EXACT []" ], "previous": [ "\"putrescine anabolism from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthesis from arginine, using agmatinase\" EXACT []", "\"putrescine formation from arginine, using agmatinase\" EXACT []", "\"putrescine synthesis from arginine, using agmatinase\" EXACT []" ] } } }, { "id": "GO:0033499", "name": "galactose catabolic process via UDP-galactose", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.\" [GOC:mah, MetaCyc:PWY-3821]" } } }, { "id": "GO:0034055", "name": "effector-mediated activation of host programmed cell death by symbiont", "changes": { "name": { "current": "effector-mediated activation of host programmed cell death by symbiont", "previous": "effector-mediated activation of programmed cell death in host" }, "synonyms": { "current": [ "\"activation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"effector-mediated activation of programmed cell death in host\" EXACT []", "\"effector-mediated induction of programmed cell death in host\" EXACT []", "\"enhancement by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related PCD\" EXACT [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related programmed cell death\" RELATED []", "\"stimulation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"up regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"up-regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"upregulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]" ], "previous": [ "\"activation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"effector-mediated induction of programmed cell death in host\" EXACT []", "\"enhancement by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related PCD\" EXACT [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related programmed cell death\" RELATED []", "\"stimulation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"up regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"up-regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"upregulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]" ] } } }, { "id": "GO:0034077", "name": "butanediol metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123]", "previous": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123, MetaCyc:BUTANEDIOL]" } } }, { "id": "GO:0034078", "name": "butanediol catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]" } } }, { "id": "GO:0034079", "name": "butanediol biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:P125-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]" } } }, { "id": "GO:0039520", "name": "symbiont-mediated activation of host autophagy", "changes": { "name": { "current": "symbiont-mediated activation of host autophagy", "previous": "induction by virus of host autophagy" }, "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. For example, some viruses are able to activate host autophagy as a cellular survival mechanism, hence delaying or inhibiting apoptosis.\" [GOC:bf, GOC:sp, VZ:846]", "previous": "\"Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.\" [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846]" }, "synonyms": { "current": [ "\"activation of host autophagy by virus\" EXACT [UniProtKB-KW:KW-1072]", "\"autophagy of host cells involved in interaction with symbiont\" RELATED []", "\"induction by virus of host autophagy\" NARROW []", "\"positive regulation by virus of host autophagy\" BROAD [GOC:bf]" ], "previous": [ "\"activation of host autophagy by virus\" EXACT [UniProtKB-KW:KW-1072]", "\"autophagy of host cells involved in interaction with symbiont\" RELATED []", "\"positive regulation by virus of host autophagy\" BROAD [GOC:bf]" ] } } }, { "id": "GO:0039522", "name": "symbiont-mediated suppression of host mRNA export from nucleus", "changes": { "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp, PMID:22334672]", "previous": "\"A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp]" } } }, { "id": "GO:0039587", "name": "symbiont-mediated-mediated suppression of host tetherin activity", "changes": { "name": { "current": "symbiont-mediated-mediated suppression of host tetherin activity", "previous": "suppression by virus of host tetherin activity" }, "definition": { "current": "\"Any process in which a symbiont stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.\" [PMID:22493439]", "previous": "\"Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.\" [PMID:22493439]" }, "synonyms": { "current": [ "\"evasion of suppression of viral release by host via inhibition of host tetherin activity\" NARROW []", "\"inhibition of host BST2/Tetherin by virus\" EXACT []", "\"suppression by virus of host tetherin activity\" EXACT []" ], "previous": [ "\"inhibition of host BST2/Tetherin by virus\" EXACT []" ] } } }, { "id": "GO:0039635", "name": "symbiont-mediated suppression of host peptidoglycan biosynthetic process", "changes": { "name": { "current": "symbiont-mediated suppression of host peptidoglycan biosynthetic process", "previous": "suppression by virus of host peptidoglycan biosynthetic process" }, "synonyms": { "current": [ "\"suppression by virus of host peptidoglycan biosynthetic process\" NARROW []", "\"viral inhibition of host peptidoglycan biosynthesis\" RELATED [GOC:bf]" ], "previous": [ "\"viral inhibition of host peptidoglycan biosynthesis\" RELATED [GOC:bf]" ] } } }, { "id": "GO:0039636", "name": "symbiont-mediated suppression of host cell wall biogenesis", "changes": { "name": { "current": "symbiont-mediated suppression of host cell wall biogenesis", "previous": "suppression by virus of host cell wall biogenesis" }, "synonyms": { "current": [ "\"suppression by virus of host cell wall biogenesis\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0039671", "name": "symbiont-mediated perturbation of host natural killer cell mediated immune response", "changes": { "name": { "current": "symbiont-mediated perturbation of host natural killer cell mediated immune response", "previous": "evasion by virus of host natural killer cell activity" }, "definition": { "current": "\"A process in which a symbiont alters or subverts the natural killer cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]", "previous": "\"Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells.\" [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]" }, "synonyms": { "current": [ "\"evasion by virus of host natural killer cell activity\" NARROW []", "\"evasion by virus of host natural killer cell response\" EXACT []", "\"evasion by virus of host NK cell killing\" EXACT [GOC:bf]", "\"modulation of host NK-cell activity by virus\" RELATED [UniProtKB-KW:KW-1131]", "\"protection by virus against host NK cell cytotoxicity\" EXACT [PMID:12782710]", "\"suppression by virus of host natural killer cell function\" NARROW [PMID:15640804]", "\"viral immunoevasion of host NK cell\" NARROW [GOC:bf]" ], "previous": [ "\"evasion by virus of host natural killer cell response\" EXACT []", "\"evasion by virus of host NK cell killing\" EXACT [GOC:bf]", "\"modulation of host NK-cell activity by virus\" RELATED [UniProtKB-KW:KW-1131]", "\"protection by virus against host NK cell cytotoxicity\" EXACT [PMID:12782710]", "\"suppression by virus of host natural killer cell function\" EXACT [PMID:15640804]", "\"viral immunoevasion of host NK cell\" EXACT [GOC:bf]" ] } } }, { "id": "GO:0039672", "name": "symbiont-mediated suppression of host natural killer cell activation", "changes": { "name": { "current": "symbiont-mediated suppression of host natural killer cell activation", "previous": "suppression by virus of host natural killer cell activation" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts natural killer cell activation in the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:10799855]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host.\" [GOC:bf, GOC:jl]" }, "synonyms": { "current": [ "\"suppression by virus of host natural killer cell activation\" NARROW []", "\"suppression by virus of host NK-cell activation\" EXACT []" ], "previous": [ "\"suppression by virus of host NK-cell activation\" EXACT [GOC:bf, GOC:jl]" ] } } }, { "id": "GO:0039673", "name": "symbiont-mediated suppression of host dendritic cell mediated immune response", "changes": { "name": { "current": "symbiont-mediated suppression of host dendritic cell mediated immune response", "previous": "evasion by virus of host dendritic cell activity" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the dendritic cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]", "previous": "\"Any process by which a virus avoids the effects mediated by the host organism's dendritic cells.\" [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]" }, "synonyms": { "current": [ "\"evasion by virus of host dendritic cell activity\" RELATED []", "\"evasion by virus of host dendritic cell response\" EXACT []", "\"impairing dendritic cell function by virus\" EXACT [UniProtKB-KW:KW-1118]", "\"modulation of host dendritic cell activity by virus\" BROAD [UniProtKB-KW:KW-1118]" ], "previous": [ "\"evasion by virus of host dendritic cell response\" EXACT []", "\"impairing dendritic cell function by virus\" EXACT [UniProtKB-KW:KW-1118]", "\"modulation of host dendritic cell activity by virus\" BROAD [UniProtKB-KW:KW-1118]" ] } } }, { "id": "GO:0042199", "name": "cyanuric acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.\" [UM-BBD_pathwayID:cya]" } } }, { "id": "GO:0042201", "name": "N-cyclopropylmelamine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.\" [UM-BBD_pathwayID:cpm]" } } }, { "id": "GO:0042203", "name": "toluene catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\" [UM-BBD_pathwayID:tol]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\" [GOC:go_curators]" } } }, { "id": "GO:0042212", "name": "cresol metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.\" [UM-BBD_pathwayID:mcr]" } } }, { "id": "GO:0042783", "name": "symbiont-mediated evasion of host immune response", "changes": { "name": { "current": "symbiont-mediated evasion of host immune response", "previous": "evasion of host immune response" }, "synonyms": { "current": [ "\"active evasion of host immune response\" RELATED []", "\"active evasion of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion\" BROAD []", "\"evasion by virus of host immune response\" RELATED []", "\"evasion of host immune response\" EXACT []", "\"evasion or tolerance of host immune response\" BROAD []", "\"immune evasion\" EXACT []", "\"mitigation by virus of host immune response\" RELATED []", "\"mitigation of host immune response\" RELATED []", "\"mitigation of host immune response by virus\" RELATED []", "\"passive evasion of host immune response\" RELATED []", "\"passive evasion of immune response of other organism involved in symbiotic interaction\" RELATED []", "\"passive immune evasion\" RELATED []", "\"suppression by virus of host immune response\" RELATED []" ], "previous": [ "\"active evasion of host immune response\" RELATED []", "\"active evasion of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion\" BROAD []", "\"evasion by virus of host immune response\" RELATED []", "\"evasion or tolerance of host immune response\" BROAD []", "\"immune evasion\" EXACT []", "\"mitigation by virus of host immune response\" RELATED []", "\"mitigation of host immune response\" RELATED []", "\"mitigation of host immune response by virus\" RELATED []", "\"passive evasion of host immune response\" RELATED []", "\"passive evasion of immune response of other organism involved in symbiotic interaction\" RELATED []", "\"passive immune evasion\" RELATED []", "\"suppression by virus of host immune response\" RELATED []" ] } } }, { "id": "GO:0043039", "name": "tRNA aminoacylation", "changes": { "definition": { "current": "\"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.\" [GOC:ma, GOC:mah]", "previous": "\"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.\" [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]" } } }, { "id": "GO:0044865", "name": "symbiont-mediated suppression of host cell division", "changes": { "name": { "current": "symbiont-mediated suppression of host cell division", "previous": "negative regulation by virus of host cell division" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the normal execution of cell division in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:24218612]", "previous": "\"Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division.\" [GOC:jl]" }, "synonyms": { "current": [ "\"inhibition by virus of host cell division\" NARROW []", "\"negative regulation by virus of host cell division\" NARROW []" ], "previous": [ "\"inhibition by virus of host cell division\" NARROW []" ] } } }, { "id": "GO:0046300", "name": "2,4-dichlorophenoxyacetic acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:ai, UM-BBD_pathwayID:2\\,4-d]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:ai]" } } }, { "id": "GO:0046494", "name": "rhizobactin 1021 metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.\" [PMID:11274118]", "previous": "\"The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.\" [MetaCyc:PWY-761, PMID:11274118]" } } }, { "id": "GO:0046499", "name": "S-adenosylmethioninamine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.\" [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]" } } }, { "id": "GO:0046597", "name": "blocking of symbiont entry into host cell", "changes": { "name": { "current": "blocking of symbiont entry into host cell", "previous": "negative regulation of viral entry into host cell" }, "definition": { "current": "\"A process in which a host inhibits or disrupts the entry of a symbiont into a host cell.\" [PMID:23544079]", "previous": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.\" [GOC:jl]" }, "synonyms": { "current": [ "\"negative regulation of symbiont entry into host cell\" RELATED []", "\"negative regulation of viral entry into host cell\" NARROW []", "\"negative regulation of viral penetration into host cell\" EXACT []", "\"prevention of symbiont entry into host cell\" EXACT []" ], "previous": [ "\"negative regulation of viral penetration into host cell\" EXACT []" ] } } }, { "id": "GO:0051504", "name": "diterpene phytoalexin precursor biosynthetic process", "changes": { "name": { "current": "diterpene phytoalexin precursor biosynthetic process", "previous": "diterpene phytoalexin precursor biosynthetic process pathway" } } }, { "id": "GO:0052081", "name": "symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway", "changes": { "definition": { "current": "\"A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:35698792]", "previous": "\"A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" } } }, { "id": "GO:0052088", "name": "symbiont-mediated perturbation of host jasmonic acid signaling", "changes": { "name": { "current": "symbiont-mediated perturbation of host jasmonic acid signaling", "previous": "symbiont defense to host-produced jasmonic acid" }, "definition": { "current": "\"A process in which a symbiont alters or subverts a jasmonic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:29222513, PMID:35698792]", "previous": "\"Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"activation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"down regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"down-regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"downregulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"induction by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"inhibition by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by organism of host JA-mediated defense response\" NARROW []", "\"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"positive regulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"suppression by organism of host JA-mediated defense response\" EXACT []", "\"suppression by symbiont of host jasmonic acid-mediated defense response\" RELATED []", "\"symbiont defense to host-produced jasmonic acid\" EXACT []", "\"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []" ], "previous": [ "\"activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"activation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"down regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"down-regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"downregulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"induction by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"inhibition by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by organism of host JA-mediated defense response\" NARROW []", "\"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"positive regulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"suppression by organism of host JA-mediated defense response\" EXACT []", "\"suppression by symbiont of host jasmonic acid-mediated defense response\" RELATED []", "\"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []" ] } } }, { "id": "GO:0052151", "name": "symbiont-mediated activation of host apoptosis", "changes": { "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981]", "previous": "\"A process in which a symbiont gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981]" } } }, { "id": "GO:0052158", "name": "symbiont-mediated perturbation of host resistance gene-dependent defense response", "changes": { "name": { "current": "symbiont-mediated perturbation of host resistance gene-dependent defense response", "previous": "modulation by symbiont of host resistance gene-dependent defense response" }, "synonyms": { "current": [ "\"modulation by organism of defense response in host by specific elicitors\" EXACT []", "\"modulation by organism of host gene-for-gene resistance\" EXACT []", "\"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont\" EXACT []", "\"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of host resistance gene-dependent defense response\" EXACT []" ], "previous": [ "\"modulation by organism of defense response in host by specific elicitors\" EXACT []", "\"modulation by organism of host gene-for-gene resistance\" EXACT []", "\"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont\" EXACT []", "\"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction\" BROAD []" ] } } }, { "id": "GO:0052165", "name": "symbiont-mediated perturbation of host phytoalexin production", "changes": { "name": { "current": "symbiont-mediated perturbation of host phytoalexin production", "previous": "symbiont defense to host-produced phytoalexin" }, "definition": { "current": "\"Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:6870275]", "previous": "\"Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"evasion or tolerance by symbiont of host-produced phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins produced by host in response to organism\" EXACT []", "\"host phytoalexin detoxification\" NARROW []", "\"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of host phytoalexin production\" NARROW []", "\"phytoalexin detoxification\" NARROW []", "\"response to host phytoalexin production\" BROAD []", "\"response to phytoalexin production by other organism involved in symbiotic interaction\" BROAD []", "\"symbiont defense to host-produced phytoalexin\" EXACT []" ], "previous": [ "\"evasion or tolerance by symbiont of host-produced phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins produced by host in response to organism\" EXACT []", "\"host phytoalexin detoxification\" NARROW []", "\"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of host phytoalexin production\" NARROW []", "\"phytoalexin detoxification\" NARROW []", "\"response to host phytoalexin production\" BROAD []", "\"response to phytoalexin production by other organism involved in symbiotic interaction\" BROAD []" ] } } }, { "id": "GO:0052200", "name": "symbiont-mediated response to host defenses", "changes": { "name": { "current": "symbiont-mediated response to host defenses", "previous": "response to host defenses" }, "synonyms": { "current": [ "\"maintenance of symbiont tolerance to host defense molecules\" NARROW []", "\"response of symbiont to host defense molecules\" NARROW []", "\"response to host defense molecules\" NARROW []", "\"response to host defenses\" EXACT []" ], "previous": [ "\"maintenance of symbiont tolerance to host defense molecules\" NARROW []", "\"response of symbiont to host defense molecules\" NARROW []", "\"response to host defense molecules\" NARROW []" ] } } }, { "id": "GO:0052315", "name": "phytoalexin biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response.\" [PMID:22209038, PMID:3882051, Wikipedia:Phytoalexin]", "previous": "\"The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response.\" [Wikipedia:Phytoalexin]" } } }, { "id": "GO:0052776", "name": "chitin catabolic process to fructose 6-phosphate via glucosamine", "changes": { "name": { "current": "chitin catabolic process to fructose 6-phosphate via glucosamine", "previous": "diacetylchitobiose catabolic process to glucosamine and acetate" }, "definition": { "current": "\"The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process.\" [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]", "previous": "\"The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate.\" [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]" }, "synonyms": { "current": [ "\"diacetylchitobiose catabolic process to glucosamine and acetate\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0061681", "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate", "changes": { "definition": { "current": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.\" [GOC:dph, PMID:12921536]", "previous": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.\" [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536]" } } }, { "id": "GO:0097250", "name": "mitochondrial respirasome assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex.\" [PMID:30030361, PMID:32311046]", "previous": "\"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.\" [GOC:mcc, PMID:21909073, PMID:22342701]" } } }, { "id": "GO:0097294", "name": "'de novo' XMP biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.\" [GOC:yaf, PMID:27590927]", "previous": "\"The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.\" [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927]" } } }, { "id": "GO:0140415", "name": "effector-mediated perturbation of host defenses by symbiont", "changes": { "name": { "current": "effector-mediated perturbation of host defenses by symbiont", "previous": "effector-mediated modulation of host defenses by symbiont" }, "synonyms": { "current": [ "\"effector-mediated modulation of host defenses by symbiont\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0140418", "name": "effector-mediated perturbation of host process by symbiont", "changes": { "name": { "current": "effector-mediated perturbation of host process by symbiont", "previous": "effector-mediated modulation of host process by symbiont" }, "synonyms": { "current": [ "\"effector mediated modulation of host process by symbiont\" EXACT []", "\"effector triggered modulation of host process by symbiont\" EXACT []", "\"effector-dependent modulation of host process by symbiont\" EXACT []", "\"effector-mediated modulation of host process by symbiont\" EXACT []" ], "previous": [ "\"effector mediated modulation of host process by symbiont\" EXACT []", "\"effector triggered modulation of host process by symbiont\" EXACT []", "\"effector-dependent modulation of host process by symbiont\" EXACT []" ] } } }, { "id": "GO:0140645", "name": "neutrophil extracellular trap formation", "changes": { "name": { "current": "neutrophil extracellular trap formation", "previous": "neutrophic extracellular trap formation" } } }, { "id": "GO:0140883", "name": "symbiont-mediated activation of host reticulophagy", "changes": { "name": { "current": "symbiont-mediated activation of host reticulophagy", "previous": "induction by virus of host reticulophagy" }, "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of host reticulophagy, leading to an increase in the frequency, rate or extent of reticulophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:35239449]", "previous": "\"Any process in which a virus activates or increases the frequency, rate or extent of reticulophagy in the host.\" [PMID:35239449]" }, "synonyms": { "current": [ "\"activation of host reticulophagy by virus\" EXACT []", "\"induction by virus of host reticulophagy\" NARROW []", "\"positive regulation by virus of host reticulophagy\" BROAD []" ], "previous": [ "\"activation of host reticulophagy by virus\" EXACT []", "\"positive regulation by virus of host reticulophagy\" BROAD []" ] } } }, { "id": "GO:0140976", "name": "host defense response against symbiont-mediated perturbation of plasma membrane integrity", "changes": { "name": { "current": "host defense response against symbiont-mediated perturbation of plasma membrane integrity", "previous": "defense response against perturbation of plasma membrane integrity" }, "synonyms": { "current": [ "\"defense response against disruption of plasma membrane integrity\" EXACT []", "\"defense response against perturbation of plasma membrane integrity\" RELATED []" ], "previous": [ "\"defense response against disruption of plasma membrane integrity\" EXACT []" ] } } }, { "id": "GO:0141154", "name": "symbiont-mediated suppression of host-directed shutoff of host translation", "changes": { "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:20563710, PMID:21622569]", "previous": "\"A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pg]" } } }, { "id": "GO:0160164", "name": "negative regulation of chromatin looping", "changes": { "name": { "current": "negative regulation of chromatin looping", "previous": "negative regulation of chromatin loopin" } } }, { "id": "GO:1901790", "name": "3-(2,3-dihydroxyphenyl)propanoate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf]", "previous": "\"The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf, MetaCyc:HCAMHPDEG-PWY]" } } }, { "id": "GO:1901807", "name": "capsanthin metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving capsanthin.\" [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]", "previous": "\"The chemical reactions and pathways involving capsanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]" } } }, { "id": "GO:1901808", "name": "capsanthin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of capsanthin.\" [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of capsanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]" } } }, { "id": "GO:1901824", "name": "alpha-carotene biosynthetic process", "changes": { "name": { "current": "alpha-carotene biosynthetic process", "previous": "delta-carotene biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of alpha-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]", "previous": "\"The chemical reactions and pathways resulting in the formation of delta-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]" }, "synonyms": { "current": [ "\"delta-carotene anabolism\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthesis\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthetic process\" EXACT []", "\"delta-carotene formation\" EXACT [GOC:TermGenie]", "\"delta-carotene synthesis\" EXACT [GOC:TermGenie]" ], "previous": [ "\"delta-carotene anabolism\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthesis\" EXACT [GOC:TermGenie]", "\"delta-carotene formation\" EXACT [GOC:TermGenie]", "\"delta-carotene synthesis\" EXACT [GOC:TermGenie]" ] } } }, { "id": "GO:1901833", "name": "neoxanthin biosynthetic process", "changes": { "name": { "current": "neoxanthin biosynthetic process", "previous": "all-trans-neoxanthin biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of trans-neoxanthin and 9'-cis-neoxanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]", "previous": "\"The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]" }, "synonyms": { "current": [ "\"all-trans-neoxanthin anabolism\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthesis\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthetic process\" NARROW []", "\"all-trans-neoxanthin formation\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin synthesis\" EXACT [GOC:TermGenie]", "\"neoxanthin anabolism\" EXACT [GOC:yaf]", "\"neoxanthin biosynthesis\" EXACT [GOC:yaf]", "\"neoxanthin formation\" EXACT [GOC:yaf]", "\"neoxanthin synthesis\" EXACT [GOC:yaf]" ], "previous": [ "\"all-trans-neoxanthin anabolism\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthesis\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin formation\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin synthesis\" EXACT [GOC:TermGenie]", "\"neoxanthin anabolism\" EXACT [GOC:yaf]", "\"neoxanthin biosynthesis\" EXACT [GOC:yaf]", "\"neoxanthin biosynthetic process\" EXACT [GOC:yaf]", "\"neoxanthin formation\" EXACT [GOC:yaf]", "\"neoxanthin synthesis\" EXACT [GOC:yaf]" ] } } }, { "id": "GO:1901864", "name": "capsorubin metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving capsorubin.\" [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]", "previous": "\"The chemical reactions and pathways involving capsorubin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]" } } }, { "id": "GO:1901865", "name": "capsorubin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of capsorubin.\" [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of capsorubin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]" } } }, { "id": "GO:1990217", "name": "symbiont-mediated suppression of host phytoalexin production", "changes": { "name": { "current": "symbiont-mediated suppression of host phytoalexin production", "previous": "suppression by symbiont of host phytoalexin production" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the production of phytoalexins in the host organism. Phytoalexins are produced by plants to fight against pathogens. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:21402357]", "previous": "\"Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:21402357]" }, "synonyms": { "current": [ "\"negative regulation by symbiont of host phytoalexin production\" EXACT []", "\"suppression by symbiont of host phytoalexin production\" EXACT []" ], "previous": [ "\"negative regulation by symbiont of host phytoalexin production\" EXACT []" ] } } } ], "cellular_component": [ { "id": "GO:0009390", "name": "dimethyl sulfoxide reductase complex", "changes": { "definition": { "current": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [PMID:21357619, PMID:3280546]", "previous": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [UM-BBD_enzymeID:r0207]" } } }, { "id": "GO:0062039", "name": "biofilm matrix", "changes": { "definition": { "current": "\"A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules.\" [PMID:22571672, PMID:27129222, PMID:28516088, PMID:32663461]", "previous": "\"A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells.\" [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088]" }, "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0098026", "name": "virus tail, tube", "changes": { "definition": { "current": "\"The internal tube of the tail of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [PMID:33188213, VZ:3960]", "previous": "\"The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [GOC:bm, VZ:3960]" }, "comment": { "current": "Applies in particular the Myoviridae bacteriophages. Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell.", "previous": "Applies in particular the Myoviridae bacteriophages." } } }, { "id": "GO:0180022", "name": "RQC-trigger complex", "changes": { "definition": { "current": "\"A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B.\" [PMID:12077347, PMID:28757607, PMID:32099016]", "previous": "\"A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (Human TRIP4).\" [PMID:28757607, PMID:32099016]" }, "synonyms": { "current": [ "\"activating signal cointegrator 1 complex\" EXACT []", "\"ASC-1 complex\" EXACT [PMID:12077347]", "\"RQT complex\" EXACT []" ], "previous": [ "\"RQT complex\" EXACT []" ] } } } ] }, "cross_references": { "molecular_function": [ { "id": "GO:0004077", "name": "biotin--[biotin carboxyl-carrier protein] ligase activity", "changes": { "xrefs": { "current": [ "EC:6.3.4.15", "MetaCyc:BIOTINLIG-RXN", "RHEA:11756" ], "previous": [ "EC:6.3.4.15", "MetaCyc:BIOTINLIG-RXN", "Reactome:R-HSA-2993447 \"HLCS biotinylates 6x(PCCA:PCCB)\"", "Reactome:R-HSA-2993799 \"HLCS biotinylates 6xMCCC1:6xMCCC2\"", "Reactome:R-HSA-2993802 \"HLCS biotinylates PC:Mn2+\"", "Reactome:R-HSA-2993814 \"HLCS biotinylates ACACA:Mn2+\"", "Reactome:R-HSA-3323184 \"Defective HLCS does not biotinylate ACACA:Mn2+\"", "Reactome:R-HSA-4167511 \"HLCS biotinylates ACACB\"", "Reactome:R-HSA-9035987 \"Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2\"", "Reactome:R-HSA-9035988 \"Defective HLCS does not biotinylate PC:Mn2+\"", "Reactome:R-HSA-9035990 \"Defective HLCS does not biotinylate 6x(PCCA:PCCB)\"", "RHEA:11756" ] } } }, { "id": "GO:0004177", "name": "aminopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.11.-", "https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE", "MetaCyc:RXN0-5052", "Reactome:R-HSA-1236954 \"Trimming of peptides by IRAP in endocytic vesicles\"", "Reactome:R-HSA-2534096 \"METAP1/2 demethylates GNAT1\"", "Reactome:R-HSA-983162 \"Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases\"" ], "previous": [ "EC:3.4.11.-", "MetaCyc:RXN0-5052", "Reactome:R-HSA-1236954 \"Trimming of peptides by IRAP in endocytic vesicles\"", "Reactome:R-HSA-2534096 \"METAP1/2 demethylates GNAT1\"", "Reactome:R-HSA-983162 \"Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases\"" ] } } }, { "id": "GO:0004197", "name": "cysteine-type endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.22.-", "Reactome:R-HSA-114252 \"Cleavage of Procaspase-3 by the apoptosome\"", "Reactome:R-HSA-114259 \"Cleavage of Procaspase9 to caspase9\"", "Reactome:R-HSA-114261 \"Cleavage of Procaspase-7 by the apoptosome\"", "Reactome:R-HSA-1236948 \"Antigen processing by cathepsin S in endosoytic vesicle\"", "Reactome:R-HSA-139898 \"Caspase-8 activates BID by cleavage\"", "Reactome:R-HSA-139952 \"Caspase-8 processing in the DISC\"", "Reactome:R-HSA-1678920 \"TLR processing at low pH\"", "Reactome:R-HSA-1678981 \"TLR9 processing at neutral pH\"", "Reactome:R-HSA-201595 \"Caspase-mediated cleavage of plakophilin-1\"", "Reactome:R-HSA-201603 \"Caspase-mediated cleavage of PKC theta\"", "Reactome:R-HSA-201608 \"Caspase-mediated cleavage of alpha adducin\"", "Reactome:R-HSA-201611 \"Caspase-mediated cleavage of Rock-1\"", "Reactome:R-HSA-201622 \"Caspase-mediated cleavage of gelsolin\"", "Reactome:R-HSA-201628 \"Caspase-mediated cleavage of vimentin at DSVD (85)\"", "Reactome:R-HSA-201629 \"Caspase-mediated cleavage of Tau\"", "Reactome:R-HSA-201630 \"Caspase-mediated cleavage of Acinus\"", "Reactome:R-HSA-201631 \"Caspase-mediated cleavage of Desmoglein 3\"", "Reactome:R-HSA-201634 \"Caspase-mediated cleavage of FADK 1\"", "Reactome:R-HSA-201636 \"Caspase-mediated cleavage of Desmoplakin\"", "Reactome:R-HSA-201637 \"Caspase-mediated cleavage of plectin-1\"", "Reactome:R-HSA-201639 \"Caspase-mediated cleavage of GAS2\"", "Reactome:R-HSA-201640 \"Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha\"", "Reactome:R-HSA-2028692 \"Cleavage of p-STK4 (p-MST1) by caspase 3\"", "Reactome:R-HSA-2028697 \"Cleavage of p-STK3 (p-MST2) by caspase 3\"", "Reactome:R-HSA-202917 \"Caspase-mediated cleavage of Desmoglein 1\"", "Reactome:R-HSA-202939 \"Caspase-mediated cleavage of E-Cadherin\"", "Reactome:R-HSA-202947 \"Caspase mediated cleavage of APC\"", "Reactome:R-HSA-202960 \"Caspase mediated cleavage of C-IAP1\"", "Reactome:R-HSA-202966 \"Caspase mediated cleavage of HIP-55\"", "Reactome:R-HSA-202967 \"Caspase mediated cleavage of alpha-II-Fodrin\"", "Reactome:R-HSA-202969 \"Caspase mediated cleavage of beta-catenin\"", "Reactome:R-HSA-211186 \"Cleavage of DFF45 (224) by caspase-3\"", "Reactome:R-HSA-211190 \"Caspase 3-mediated cleavage of DFF45 (117)\"", "Reactome:R-HSA-211651 \"Cleavage of PAK-2 at 212\"", "Reactome:R-HSA-212552 \"Caspase 3-mediated cleavage of PKC delta\"", "Reactome:R-HSA-2130336 \"Initial proteolyis of Ii by aspartic proteases to lip22\"", "Reactome:R-HSA-2130349 \"Generation of CLIP from lip10\"", "Reactome:R-HSA-2130504 \"Cleavage of lip22 to lip10\"", "Reactome:R-HSA-2130706 \"MHC class II antigen processing\"", "Reactome:R-HSA-2562564 \"Caspase-8 processing within TLR4 complex\"", "Reactome:R-HSA-264865 \"Caspase-mediated cleavage of Lamin A\"", "Reactome:R-HSA-264871 \"Caspase-mediated cleavage of Lamin B1\"", "Reactome:R-HSA-3465448 \"Caspase-8 and FLIP(L) processing at DISC\"", "Reactome:R-HSA-350158 \"LGMN degrades GC\"", "Reactome:R-HSA-350318 \"Caspase-mediated cleavage of vimentin at TNLD (429)\"", "Reactome:R-HSA-350319 \"Caspase mediated cleavage of vimentin at IDVD (259)\"", "Reactome:R-HSA-350651 \"Caspase-mediated cleavage of MASK\"", "Reactome:R-HSA-351849 \"Caspase-mediated cleavage of Etk\"", "Reactome:R-HSA-351871 \"Caspase-mediated cleavage of Z0-2\"", "Reactome:R-HSA-351876 \"Caspase-mediated cleavage of occludin\"", "Reactome:R-HSA-351877 \"Caspase-mediated cleavage of Desmoglein 2\"", "Reactome:R-HSA-351894 \"Caspase mediated cleavage of BAP31\"", "Reactome:R-HSA-351901 \"Caspase-mediated cleavage of MST3\"", "Reactome:R-HSA-351913 \"Caspase-mediated cleavage of TJP1\"", "Reactome:R-HSA-351936 \"Caspase-mediated cleavage of claspin\"", "Reactome:R-HSA-352268 \"Cleavage of Satb1\"", "Reactome:R-HSA-418845 \"Activation of caspase-3\"", "Reactome:R-HSA-418846 \"Caspase cleavage of UNC5A\"", "Reactome:R-HSA-418852 \"Caspase cleavage of UNC5B\"", "Reactome:R-HSA-448703 \"Interleukin-1 family precursors are cleaved by caspase-1\"", "Reactome:R-HSA-5357828 \"RIPK1 is cleaved by CASP8\"", "Reactome:R-HSA-5634228 \"TRAF1 is cleaved by caspases\"", "Reactome:R-HSA-5660663 \"Caspase-8 cleaves IL1B precursor\"", "Reactome:R-HSA-5681987 \"LC3 is cleaved by ATG4\"", "Reactome:R-HSA-5682377 \"LC3 de-lipidation by ATG4\"", "Reactome:R-HSA-6814387 \"CASP14 cleaves filaggrin\"", "Reactome:R-HSA-9012556 \"IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37\"", "Reactome:R-HSA-9013895 \"Caspase-8 processing within TLR3 complex\"", "Reactome:R-HSA-933532 \"Processing of caspases\"", "Reactome:R-HSA-9603534 \"Unknown caspase cleaves NTRK3\"", "Reactome:R-HSA-9647632 \"CASP3 cleaves GSDME\"", "Reactome:R-HSA-9647680 \"CASP1 cleaves GSDMD\"", "Reactome:R-HSA-9647999 \"RCE1 cleaves S-Farn proRAS proteins\"", "Reactome:R-HSA-9684273 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9684309 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9684321 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9684336 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9684340 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9684351 \"pp1a cleaves itself\"", "Reactome:R-HSA-9684352 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9686088 \"CASP3 cleaves GSDMD\"", "Reactome:R-HSA-9686930 \"RIPK3 is cleaved by CASP8\"", "Reactome:R-HSA-9693929 \"RIPK1 variant is not cleaved by CASP8\"", "Reactome:R-HSA-9694338 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9694377 \"pp1a cleaves itself\"", "Reactome:R-HSA-9694441 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9694551 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9694601 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9694625 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9694732 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9697750 \"RIPK1 is cleaved by CASP8:FLIP(L)\"", "Reactome:R-HSA-9710101 \"CASP4, CASP5 cleave GSDMD\"", "Reactome:R-HSA-9729704 \"SARS-CoV-2 3CLpro dimer cleaves TAB1\"", "Reactome:R-HSA-9729730 \"SARS-CoV-2 nsp3 cleaves IRF3\"", "Reactome:R-HSA-9729741 \"SARS-CoV-2 3CLpro dimer cleaves NLRP12\"" ], "previous": [ "EC:3.4.22.-", "Reactome:R-HSA-114252 \"Cleavage of Procaspase-3 by the apoptosome\"", "Reactome:R-HSA-114259 \"Cleavage of Procaspase9 to caspase9\"", "Reactome:R-HSA-114261 \"Cleavage of Procaspase-7 by the apoptosome\"", "Reactome:R-HSA-1236948 \"Antigen processing by cathepsin S in endosoytic vesicle\"", "Reactome:R-HSA-139898 \"Caspase-8 activates BID by cleavage\"", "Reactome:R-HSA-139952 \"Caspase-8 processing in the DISC\"", "Reactome:R-HSA-1678920 \"TLR processing at low pH\"", "Reactome:R-HSA-1678981 \"TLR9 processing at neutral pH\"", "Reactome:R-HSA-201595 \"Caspase-mediated cleavage of plakophilin-1\"", "Reactome:R-HSA-201603 \"Caspase-mediated cleavage of PKC theta\"", "Reactome:R-HSA-201608 \"Caspase-mediated cleavage of alpha adducin\"", "Reactome:R-HSA-201611 \"Caspase-mediated cleavage of Rock-1\"", "Reactome:R-HSA-201622 \"Caspase-mediated cleavage of gelsolin\"", "Reactome:R-HSA-201628 \"Caspase-mediated cleavage of vimentin at DSVD (85)\"", "Reactome:R-HSA-201629 \"Caspase-mediated cleavage of Tau\"", "Reactome:R-HSA-201630 \"Caspase-mediated cleavage of Acinus\"", "Reactome:R-HSA-201631 \"Caspase-mediated cleavage of Desmoglein 3\"", "Reactome:R-HSA-201634 \"Caspase-mediated cleavage of FADK 1\"", "Reactome:R-HSA-201636 \"Caspase-mediated cleavage of Desmoplakin\"", "Reactome:R-HSA-201637 \"Caspase-mediated cleavage of plectin-1\"", "Reactome:R-HSA-201639 \"Caspase-mediated cleavage of GAS2\"", "Reactome:R-HSA-201640 \"Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha\"", "Reactome:R-HSA-2028692 \"Cleavage of p-STK4 (p-MST1) by caspase 3\"", "Reactome:R-HSA-2028697 \"Cleavage of p-STK3 (p-MST2) by caspase 3\"", "Reactome:R-HSA-202917 \"Caspase-mediated cleavage of Desmoglein 1\"", "Reactome:R-HSA-202939 \"Caspase-mediated cleavage of E-Cadherin\"", "Reactome:R-HSA-202947 \"Caspase mediated cleavage of APC\"", "Reactome:R-HSA-202960 \"Caspase mediated cleavage of C-IAP1\"", "Reactome:R-HSA-202966 \"Caspase mediated cleavage of HIP-55\"", "Reactome:R-HSA-202967 \"Caspase mediated cleavage of alpha-II-Fodrin\"", "Reactome:R-HSA-202969 \"Caspase mediated cleavage of beta-catenin\"", "Reactome:R-HSA-211186 \"Cleavage of DFF45 (224) by caspase-3\"", "Reactome:R-HSA-211190 \"Caspase 3-mediated cleavage of DFF45 (117)\"", "Reactome:R-HSA-211651 \"Cleavage of PAK-2 at 212\"", "Reactome:R-HSA-212552 \"Caspase 3-mediated cleavage of PKC delta\"", "Reactome:R-HSA-2130336 \"Initial proteolyis of Ii by aspartic proteases to lip22\"", "Reactome:R-HSA-2130349 \"Generation of CLIP from lip10\"", "Reactome:R-HSA-2130504 \"Cleavage of lip22 to lip10\"", "Reactome:R-HSA-2130706 \"MHC class II antigen processing\"", "Reactome:R-HSA-2562564 \"Caspase-8 processing within TLR4 complex\"", "Reactome:R-HSA-264865 \"Caspase-mediated cleavage of Lamin A\"", "Reactome:R-HSA-264871 \"Caspase-mediated cleavage of Lamin B1\"", "Reactome:R-HSA-3465448 \"Caspase-8 and FLIP(L) processing at DISC\"", "Reactome:R-HSA-350158 \"LGMN degrades GC\"", "Reactome:R-HSA-350318 \"Caspase-mediated cleavage of vimentin at TNLD (429)\"", "Reactome:R-HSA-350319 \"Caspase mediated cleavage of vimentin at IDVD (259)\"", "Reactome:R-HSA-350651 \"Caspase-mediated cleavage of MASK\"", "Reactome:R-HSA-351849 \"Caspase-mediated cleavage of Etk\"", "Reactome:R-HSA-351871 \"Caspase-mediated cleavage of Z0-2\"", "Reactome:R-HSA-351876 \"Caspase-mediated cleavage of occludin\"", "Reactome:R-HSA-351877 \"Caspase-mediated cleavage of Desmoglein 2\"", "Reactome:R-HSA-351894 \"Caspase mediated cleavage of BAP31\"", "Reactome:R-HSA-351901 \"Caspase-mediated cleavage of MST3\"", "Reactome:R-HSA-351913 \"Caspase-mediated cleavage of TJP1\"", "Reactome:R-HSA-351936 \"Caspase-mediated cleavage of claspin\"", "Reactome:R-HSA-352268 \"Cleavage of Satb1\"", "Reactome:R-HSA-418845 \"Activation of caspase-3\"", "Reactome:R-HSA-418846 \"Caspase cleavage of UNC5A\"", "Reactome:R-HSA-418852 \"Caspase cleavage of UNC5B\"", "Reactome:R-HSA-448703 \"Interleukin-1 family precursors are cleaved by caspase-1\"", "Reactome:R-HSA-5357828 \"RIPK1 is cleaved by CASP8\"", "Reactome:R-HSA-5634228 \"TRAF1 is cleaved by caspases\"", "Reactome:R-HSA-5660663 \"Caspase-8 cleaves IL1B precursor\"", "Reactome:R-HSA-5681987 \"LC3 is cleaved by ATG4\"", "Reactome:R-HSA-5682377 \"LC3 de-lipidation by ATG4\"", "Reactome:R-HSA-6800797 \"The PIDDosome activates CASP2\"", "Reactome:R-HSA-6814387 \"CASP14 cleaves filaggrin\"", "Reactome:R-HSA-9012556 \"IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37\"", "Reactome:R-HSA-9013895 \"Caspase-8 processing within TLR3 complex\"", "Reactome:R-HSA-933532 \"Processing of caspases\"", "Reactome:R-HSA-9603534 \"Unknown caspase cleaves NTRK3\"", "Reactome:R-HSA-9647632 \"CASP3 cleaves GSDME\"", "Reactome:R-HSA-9647680 \"CASP1 cleaves GSDMD\"", "Reactome:R-HSA-9647999 \"RCE1 cleaves S-Farn proRAS proteins\"", "Reactome:R-HSA-9684273 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9684309 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9684321 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9684336 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9684340 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9684351 \"pp1a cleaves itself\"", "Reactome:R-HSA-9684352 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9686088 \"CASP3 cleaves GSDMD\"", "Reactome:R-HSA-9686930 \"RIPK3 is cleaved by CASP8\"", "Reactome:R-HSA-9693929 \"RIPK1 variant is not cleaved by CASP8\"", "Reactome:R-HSA-9694338 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9694377 \"pp1a cleaves itself\"", "Reactome:R-HSA-9694441 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9694551 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9694601 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9694625 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9694732 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9697750 \"RIPK1 is cleaved by CASP8:FLIP(L)\"", "Reactome:R-HSA-9710101 \"CASP4, CASP5 cleave GSDMD\"", "Reactome:R-HSA-9729704 \"SARS-CoV-2 3CLpro dimer cleaves TAB1\"", "Reactome:R-HSA-9729730 \"SARS-CoV-2 nsp3 cleaves IRF3\"", "Reactome:R-HSA-9729741 \"SARS-CoV-2 3CLpro dimer cleaves NLRP12\"" ] } } }, { "id": "GO:0004619", "name": "phosphoglycerate mutase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R01516", "Reactome:R-HSA-71445 \"PGAM dimers (PGAM1,2) isomerise 2PG to 3PG\"", "Reactome:R-HSA-71654 \"3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate\"", "RHEA:15901" ], "previous": [ "Reactome:R-HSA-71445 \"PGAM dimers (PGAM1,2) isomerise 2PG to 3PG\"", "Reactome:R-HSA-71654 \"3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate\"", "RHEA:15901" ] } } }, { "id": "GO:0004674", "name": "protein serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.-", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"" ], "previous": [ "EC:2.7.11.1", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"" ] } } }, { "id": "GO:0008396", "name": "oxysterol 7-alpha-hydroxylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-191972 \"27-hydroxycholesterol is 7alpha-hydroxylated\"", "Reactome:R-HSA-192065 \"CYP7B1 7-hydroxylates 25OH-CHOL\"", "Reactome:R-HSA-192178 \"CYP39A1 7-hydroxylates 24OH-CHOL\"", "Reactome:R-HSA-5602885 \"Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL\"", "RHEA:68740" ], "previous": [ "Reactome:R-HSA-191972 \"27-hydroxycholesterol is 7alpha-hydroxylated\"", "Reactome:R-HSA-192065 \"CYP7B1 7-hydroxylates 25OH-CHOL\"", "Reactome:R-HSA-192178 \"CYP39A1 7-hydroxylates 24OH-CHOL\"", "Reactome:R-HSA-5602885 \"Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL\"" ] } } }, { "id": "GO:0008412", "name": "4-hydroxybenzoate polyprenyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.5.1.39", "MetaCyc:RXN-11368", "RHEA:44504" ], "previous": [ "EC:2.5.1.39", "MetaCyc:RXN-11368", "Reactome:R-HSA-2162192 \"COQ2 ligates all-E-10PrP2 to PHB\"", "RHEA:44504" ] } } }, { "id": "GO:0008695", "name": "3-phenylpropionate dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.12.19", "MetaCyc:HCAMULTI-RXN", "RHEA:20357", "UM-BBD_enzymeID:e0307" ], "previous": [ "EC:1.14.12.19", "MetaCyc:HCAMULTI-RXN", "RHEA:20357", "UM-BBD_enzymeID:r0434" ] } } }, { "id": "GO:0008942", "name": "nitrite reductase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377" ], "previous": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377", "RHEA:24632" ] } } }, { "id": "GO:0016303", "name": "1-phosphatidylinositol-3-kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.137", "KEGG_REACTION:R03362", "MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN", "Reactome:R-HSA-109699 \"PI3K-containing complexes phosphorylate PIP2 to PIP3\"", "Reactome:R-HSA-1433514 \"Synthesis of PIP3 from PIP2 by PI3K\"", "Reactome:R-HSA-1675939 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane\"", "Reactome:R-HSA-1675961 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane\"", "Reactome:R-HSA-1676024 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane\"", "Reactome:R-HSA-2045911 \"BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3\"", "Reactome:R-HSA-5672012 \"Beclin-1 complex phosphorylates PtdIns\"", "Reactome:R-HSA-6798174 \"PIK3C3:PIK3R4 phosphorylates PI to PI3P\"", "Reactome:R-HSA-9670433 \"KIT mutants:PI3K catalyze synthesis of PIP3\"", "Reactome:R-HSA-9680389 \"CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2\"", "RHEA:12709" ], "previous": [ "EC:2.7.1.137", "KEGG_REACTION:R03362", "MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN", "Reactome:R-HSA-109699 \"PI3K-containing complexes phosphorylate PIP2 to PIP3\"", "Reactome:R-HSA-1433514 \"Synthesis of PIP3 from PIP2 by PI3K\"", "Reactome:R-HSA-1675939 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane\"", "Reactome:R-HSA-1675961 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane\"", "Reactome:R-HSA-1676024 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane\"", "Reactome:R-HSA-2045911 \"BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3\"", "Reactome:R-HSA-5672012 \"Beclin-1 complex phosphorylates PtdIns\"", "Reactome:R-HSA-6798174 \"PIK3C3:PIK3R4 phosphorylates PI to PI3P\"", "Reactome:R-HSA-9670433 \"KIT mutants:PI3K catalyze synthesis of PIP3\"", "Reactome:R-HSA-9680389 \"CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2\"", "RHEA:12709", "Wikipedia:Phosphoinositide_3-kinase" ] } } }, { "id": "GO:0017040", "name": "N-acylsphingosine amidohydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"", "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"", "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"", "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"", "RHEA:20856" ], "previous": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"", "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"", "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"", "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"", "Reactome:R-HSA-428262 \"ACER3 hydrolyzes phytoceramide\"", "RHEA:20856" ] } } }, { "id": "GO:0018591", "name": "methyl tertiary butyl ether 3-monooxygenase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r1023" ], "previous": "N/A" } } }, { "id": "GO:0018594", "name": "tert-butanol 2-monooxygenase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r0615" ], "previous": "N/A" } } }, { "id": "GO:0018755", "name": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r1414" ], "previous": "N/A" } } }, { "id": "GO:0018812", "name": "3-hydroxyacyl-CoA dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.74", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:33767" ], "previous": [ "EC:4.2.1.74", "MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:33767" ] } } }, { "id": "GO:0019833", "name": "ice nucleation activity", "changes": { "xrefs": { "current": [ "TC:9.B.133.1.1" ], "previous": "N/A" } } }, { "id": "GO:0035241", "name": "protein-arginine omega-N monomethyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.321", "RHEA:48100" ], "previous": [ "EC:2.1.1.321", "MetaCyc:2.1.1.124-RXN", "RHEA:48100" ] } } }, { "id": "GO:0035244", "name": "protein-arginine C-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.379", "RHEA:66028" ], "previous": [ "EC:2.1.1.379", "RESID:AA0272", "RHEA:66028" ] } } }, { "id": "GO:0043786", "name": "cinnamate reductase activity", "changes": { "xrefs": { "current": [ "RHEA:50944" ], "previous": "N/A" } } }, { "id": "GO:0047403", "name": "lacto-N-biosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.140", "MetaCyc:RXN-8731", "RHEA:21568" ], "previous": [ "EC:3.2.1.140", "RHEA:21568" ] } } }, { "id": "GO:0047792", "name": "cyanohydrin beta-glucosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.85", "MetaCyc:RXN-743", "RHEA:12853" ], "previous": [ "EC:2.4.1.85", "RHEA:12853" ] } } }, { "id": "GO:0051996", "name": "squalene synthase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:2.5.1.21", "MetaCyc:RXN66-281" ], "previous": [ "EC:2.5.1.21", "MetaCyc:RXN66-281", "Reactome:R-HSA-191402 \"Reduction of presqualene diphosphate to form squalene\"", "Reactome:R-HSA-191405 \"Two FPP molecules dimerize to form presqualene diphosphate\"" ] } } }, { "id": "GO:0052849", "name": "curcumin reductase (NADP+) activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN0-6676", "RHEA:34815" ], "previous": [ "EC:1.3.1.n3", "MetaCyc:RXN0-6676" ] } } }, { "id": "GO:0052856", "name": "NAD(P)HX epimerase activity", "changes": { "xrefs": { "current": [ "EC:5.1.99.6" ], "previous": [ "EC:5.1.99.6", "Reactome:R-HSA-6806966 \"APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX\"" ] } } }, { "id": "GO:0052903", "name": "N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity", "changes": { "xrefs": { "current": [ "EC:1.5.3.13", "KEGG_REACTION:R03899", "MetaCyc:RXN-12090" ], "previous": [ "EC:1.5.3.13", "KEGG_REACTION:R03899", "MetaCyc:RXN-12090", "Reactome:R-HSA-141348 \"PAO:FAD oxidises NASPM to PTCN\"", "Reactome:R-HSA-141351 \"PAOX:FAD oxidises NASPN to SPM\"" ] } } }, { "id": "GO:0055056", "name": "D-glucose transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429094 \"SLC2A6,8,10,12 transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-450095 \"GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region\"", "Reactome:R-HSA-5339524 \"GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632804 \"SLC2A1 tetramer does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632871 \"Defective SLC2A10 does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981553 \"GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981564 \"GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981570 \"GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981574 \"GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol\"" ], "previous": [ "Reactome:R-HSA-429094 \"SLC2A6,8,10,12 transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-450095 \"GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region\"", "Reactome:R-HSA-499981 \"Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2\"", "Reactome:R-HSA-5339524 \"GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632804 \"SLC2A1 tetramer does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632871 \"Defective SLC2A10 does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5653873 \"SLC2A1 tetramer transports Glc from cytosol to Golgi lumen\"", "Reactome:R-HSA-8981553 \"GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981564 \"GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981570 \"GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981574 \"GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol\"" ] } } }, { "id": "GO:0062101", "name": "peptidyl-aspartic acid 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RHEA:11508" ], "previous": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RESID:AA0026", "RHEA:11508" ] } } }, { "id": "GO:0070330", "name": "aromatase activity", "changes": { "xrefs": { "current": [ "EC:1.14.14.14" ], "previous": [ "EC:1.14.14.14", "UM-BBD_reactionID:r1132", "UM-BBD_reactionID:r1137" ] } } }, { "id": "GO:0102140", "name": "heparan sulfate N-deacetylase activity", "changes": { "xrefs": { "current": [ "RHEA:70587" ], "previous": [ "MetaCyc:RXN-11557" ] } } }, { "id": "GO:0102274", "name": "glutathione S-conjugate carboxypeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.17.25", "MetaCyc:RXN-12532", "RHEA:60448" ], "previous": [ "MetaCyc:RXN-12532" ] } } }, { "id": "GO:0103031", "name": "L-Ala-D/L-Glu epimerase activity", "changes": { "xrefs": { "current": [ "EC:5.1.1.20", "MetaCyc:RXN0-5228", "RHEA:28394" ], "previous": [ "MetaCyc:RXN0-5228", "RHEA:28394" ] } } }, { "id": "GO:0106359", "name": "2-hydroxyacyl-CoA lyase activity", "changes": { "xrefs": { "current": [ "EC:4.1.2.63" ], "previous": [ "EC:4.1.2.63", "MetaCyc:RXN66-471" ] } } }, { "id": "GO:0141207", "name": "peptide lactyltransferase (ATP-dependent) activity", "changes": { "xrefs": { "current": [ "RHEA:80271" ], "previous": "N/A" } } }, { "id": "GO:0141208", "name": "NAD-dependent protein lysine delactylase activity", "changes": { "xrefs": { "current": [ "RHEA:80287" ], "previous": "N/A" } } }, { "id": "GO:0160128", "name": "pH-gated monoatomic ion channel activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2671885 \"ASIC trimers:H+ transport extracellular Na+ to cytosol\"" ], "previous": [ "Reactome:R-HSA-2671885 \"ASIC trimers:H+ transport extracellular Na+ to cytosol\"", "Wikipedia:Acid-sensing_ion_channel" ] } } }, { "id": "GO:0160198", "name": "polyprenal reductase activity", "changes": { "xrefs": { "current": [ "EC:1.3.1.94", "MetaCyc:RXN-9971", "RHEA:80727" ], "previous": [ "EC:1.3.1.94", "MetaCyc:RXN-9971" ] } } }, { "id": "GO:1990055", "name": "phenylacetaldehyde synthase activity", "changes": { "xrefs": { "current": [ "EC:4.1.1.109", "MetaCyc:RXN-8990", "RHEA:55532" ], "previous": [ "EC:4.1.1.109", "RHEA:55532" ] } } } ], "biological_process": [ { "id": "GO:0006113", "name": "fermentation", "changes": { "xrefs": { "current": [ "MetaCyc:Fermentation", "Wikipedia:Fermentation_(biochemistry)" ], "previous": [ "MetaCyc:FERMENTATION-PWY", "Wikipedia:Fermentation_(biochemistry)" ] } } }, { "id": "GO:0006601", "name": "creatine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCGREAT-PWY" ], "previous": "N/A" } } }, { "id": "GO:0010142", "name": "farnesyl diphosphate biosynthetic process, mevalonate pathway", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:PWY-922" ] } } }, { "id": "GO:0018868", "name": "2-aminobenzenesulfonate metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:abs" ] } } }, { "id": "GO:0018873", "name": "atrazine metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:atr" ] } } }, { "id": "GO:0018874", "name": "benzoate metabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:benz2" ], "previous": [ "MetaCyc:P321-PWY", "UM-BBD_pathwayID:benz2" ] } } }, { "id": "GO:0018875", "name": "anaerobic benzoate metabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:benz" ], "previous": [ "MetaCyc:CENTBENZCOA-PWY", "UM-BBD_pathwayID:benz" ] } } }, { "id": "GO:0018882", "name": "(+)-camphor metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:cam" ] } } }, { "id": "GO:0018901", "name": "2,4-dichlorophenoxyacetic acid metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:2\\,4-d" ] } } }, { "id": "GO:0018952", "name": "parathion metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:pthn" ] } } }, { "id": "GO:0019287", "name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-922" ], "previous": "N/A" } } }, { "id": "GO:0019339", "name": "parathion catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PARATHION-DEGRADATION-PWY", "UM-BBD_pathwayID:pthn" ], "previous": [ "MetaCyc:PARATHION-DEGRADATION-PWY" ] } } }, { "id": "GO:0019381", "name": "atrazine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5724", "UM-BBD_pathwayID:atr" ], "previous": [ "MetaCyc:PWY-5724" ] } } }, { "id": "GO:0019383", "name": "(+)-camphor catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:P601-PWY", "UM-BBD_pathwayID:cam" ], "previous": [ "MetaCyc:P601-PWY" ] } } }, { "id": "GO:0019490", "name": "2-aminobenzenesulfonate desulfonation", "changes": { "xrefs": { "current": [ "MetaCyc:2ASDEG-PWY", "UM-BBD_pathwayID:abs" ], "previous": [ "MetaCyc:2ASDEG-PWY" ] } } }, { "id": "GO:0019664", "name": "mixed acid fermentation", "changes": { "xrefs": { "current": [ "MetaCyc:FERMENTATION-PWY", "Wikipedia:Mixed_acid_fermentation" ], "previous": [ "Wikipedia:Mixed_acid_fermentation" ] } } }, { "id": "GO:0033387", "name": "putrescine biosynthetic process from arginine, via ornithine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-46" ], "previous": "N/A" } } }, { "id": "GO:0033389", "name": "putrescine biosynthetic process from arginine, via agmatine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-40" ], "previous": "N/A" } } }, { "id": "GO:0033390", "name": "putrescine biosynthetic process from arginine via N-carbamoylputrescine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-43" ], "previous": "N/A" } } }, { "id": "GO:0039587", "name": "symbiont-mediated-mediated suppression of host tetherin activity", "changes": { "xrefs": { "current": [ "VZ:665" ], "previous": "N/A" } } }, { "id": "GO:0039673", "name": "symbiont-mediated suppression of host dendritic cell mediated immune response", "changes": { "xrefs": { "current": [ "VZ:869" ], "previous": "N/A" } } }, { "id": "GO:0042203", "name": "toluene catabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:tol" ], "previous": "N/A" } } }, { "id": "GO:0046300", "name": "2,4-dichlorophenoxyacetic acid catabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:2\\,4-d" ], "previous": "N/A" } } }, { "id": "GO:0052150", "name": "symbiont-mediated perturbation of host apoptosis", "changes": { "xrefs": { "current": [ "VZ:1518 \"Apoptosis modulation\"" ], "previous": [ "VZ:1518 \"Apoptosis modulation\"", "VZ:1581 \"Apoptosis modulation\"" ] } } }, { "id": "GO:0052165", "name": "symbiont-mediated perturbation of host phytoalexin production", "changes": { "xrefs": { "current": [ "PMID:28805743" ], "previous": "N/A" } } }, { "id": "GO:0052776", "name": "chitin catabolic process to fructose 6-phosphate via glucosamine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6855" ], "previous": "N/A" } } }, { "id": "GO:0071514", "name": "genomic imprinting", "changes": { "xrefs": { "current": "N/A", "previous": [ "Wikipedia:Genomic_imprinting" ] } } }, { "id": "GO:0090638", "name": "phosphatidylcholine biosynthesis from phosphatidylethanolamine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6825" ], "previous": "N/A" } } }, { "id": "GO:0090640", "name": "phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7470" ], "previous": "N/A" } } }, { "id": "GO:1901158", "name": "neomycin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7016" ], "previous": "N/A" } } }, { "id": "GO:1901774", "name": "lincomycin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6955" ], "previous": "N/A" } } }, { "id": "GO:1901780", "name": "pentalenolactone biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6915" ], "previous": "N/A" } } }, { "id": "GO:1901782", "name": "p-cumate catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5273" ], "previous": "N/A" } } }, { "id": "GO:1901802", "name": "1,5-anhydro-D-fructose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6992" ], "previous": "N/A" } } }, { "id": "GO:1901812", "name": "beta-carotene biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5943" ], "previous": "N/A" } } }, { "id": "GO:1901815", "name": "astaxanthin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5288" ], "previous": "N/A" } } }, { "id": "GO:1901824", "name": "alpha-carotene biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5946" ], "previous": "N/A" } } }, { "id": "GO:1901827", "name": "zeaxanthin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5944" ], "previous": "N/A" } } }, { "id": "GO:1901830", "name": "zeaxanthin bis(beta-D-glucoside) biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6288" ], "previous": "N/A" } } }, { "id": "GO:1901833", "name": "neoxanthin biosynthetic process", 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