CHANGES IN GO ONTOLOGY SUMMARY: CURRENT RELEASE release_date 2024-11-24 valid_terms 40583 obsolete_terms 7347 merged_terms 2436 biological_process_terms 26412 molecular_function_terms 10147 cellular_component_terms 4024 meta_statements 276911 cross_references 23667 terms_relations 81213 SUMMARY: PREVIOUS RELEASE release_date 2024-11-03 valid_terms 40635 obsolete_terms 7286 merged_terms 2436 biological_process_terms 26467 molecular_function_terms 10146 cellular_component_terms 4022 meta_statements 277271 cross_references 23657 terms_relations 81335 SUMMARY: DIFF BETWEEN RELEASES changes_created_terms 9 changes_valid_terms -52 changes_obsolete_terms 65 changes_merged_terms 0 changes_biological_process_terms -55 changes_molecular_function_terms 1 changes_cellular_component_terms 2 changes_meta_statements 234 changes_meta_statements_by_term 149 changes_cross_references 133 changes_cross_references_by_term 77 changes_relations 156 changes_relations_by_term 141 DETAILED CHANGES 9 CREATED TERMS biological_process GO:0014000 morula development biological_process GO:0140001 morula formation biological_process GO:0160221 Rho-activating G protein-coupled receptor signaling pathway molecular_function GO:0120531 prenyl diphosphate synthase activity molecular_function GO:0160220 D-alanine-(R)-lactate ligase activity molecular_function GO:0160222 D-alanine-D-serine ligase activity cellular_component GO:0151001 tuft cellular_component GO:0160219 cortical endoplasmic reticulum membrane cellular_component GO:0160223 pyrenoid tubule 65 OBSOLETED TERMS CHANGES biological_process GO:0006025 galactosaminoglycan biosynthetic process biological_process GO:0006028 galactosaminoglycan catabolic process biological_process GO:0006880 intracellular sequestering of iron ion biological_process GO:0006881 extracellular sequestering of iron ion biological_process GO:0007253 cytoplasmic sequestering of NF-kappaB biological_process GO:0009689 induction of phytoalexin biosynthetic process biological_process GO:0019048 modulation by virus of host process biological_process GO:0019049 virus-mediated perturbation of host defense response biological_process GO:0019054 modulation by virus of host cellular process biological_process GO:0019325 anaerobic fructose catabolic process biological_process GO:0019463 glycine catabolic process to creatine biological_process GO:0019576 aerobic fructose catabolic process biological_process GO:0032119 sequestering of zinc ion biological_process GO:0034053 symbiont-mediated perturbation of host defense-related programmed cell death biological_process GO:0034054 symbiont-mediated suppression of host defense-related programmed cell death biological_process GO:0036167 phenotypic switching in response to host biological_process GO:0039501 suppression by virus of host type I interferon production biological_process GO:0039519 modulation by virus of host autophagy biological_process GO:0039521 suppression by virus of host autophagy biological_process GO:0039637 catabolism by virus of host DNA biological_process GO:0042137 sequestering of neurotransmitter biological_process GO:0042989 sequestering of actin monomers biological_process GO:0042994 cytoplasmic sequestering of transcription factor biological_process GO:0044418 translocation of DNA into host biological_process GO:0044501 perturbation of signal transduction in another organism biological_process GO:0044831 modulation by virus of host cytokine production biological_process GO:0044833 modulation by virus of host protein transport biological_process GO:0044863 modulation by virus of host cell division biological_process GO:0044864 positive regulation by virus of host cell division biological_process GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity biological_process GO:0046350 galactosaminoglycan metabolic process biological_process GO:0046774 suppression by virus of host intracellular interferon activity biological_process GO:0046775 suppression by virus of host cytokine production biological_process GO:0050788 sequestering of mercury biological_process GO:0051220 cytoplasmic sequestering of protein biological_process GO:0051238 sequestering of metal ion biological_process GO:0052089 modulation by symbiont of host salicylic acid-mediated defense response biological_process GO:0052173 response to defenses of other organism biological_process GO:0052318 regulation of phytoalexin metabolic process biological_process GO:0052319 regulation of phytoalexin biosynthetic process biological_process GO:0052320 positive regulation of phytoalexin metabolic process biological_process GO:0052321 negative regulation of phytoalexin metabolic process biological_process GO:0052323 negative regulation of phytoalexin biosynthetic process biological_process GO:0052403 negative regulation by host of symbiont catalytic activity biological_process GO:0052422 modulation by host of symbiont catalytic activity biological_process GO:0060858 vesicle-mediated transport involved in floral organ abscission biological_process GO:0075528 perturbation by virus of host immune response biological_process GO:0097577 sequestering of iron ion biological_process GO:0097578 sequestering of copper ion biological_process GO:0097579 extracellular sequestering of copper ion biological_process GO:0097580 intracellular sequestering of copper ion biological_process GO:0140133 symbiont-mediated suppression of host cytokine production biological_process GO:0141088 symbiont-mediated activation of host autophagy biological_process GO:0141132 defense response to host biological_process GO:1901182 regulation of camalexin biosynthetic process biological_process GO:1903652 modulation by virus of host cytoplasmic transport biological_process GO:1990659 sequestering of manganese ion biological_process GO:1990969 modulation by host of viral RNA-binding transcription factor activity molecular_function GO:0010012 steroid 22-alpha hydroxylase activity molecular_function GO:0030374 nuclear receptor coactivator activity molecular_function GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity molecular_function GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity molecular_function GO:0052850 NADPH-dependent dihydrocurcumin reductase activity molecular_function GO:0140536 nuclear receptor corepressor activity cellular_component GO:0099053 activating signal cointegrator 1 complex 0 MERGED TERMS CHANGES 149 META CHANGES molecular_function GO:0000246 Delta24(24-1) sterol reductase activity name Delta24(24-1) sterol reductase activity WAS delta24(24-1) sterol reductase activity molecular_function GO:0003707 nuclear steroid receptor activity definition "A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:14708019] WAS "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] molecular_function GO:0004111 creatine kinase activity comment Note that this term has a MetaCyc pathway reference as the pathway only has a single step. WAS N/A molecular_function GO:0004161 dimethylallyltranstransferase activity synonyms "(2E,6E)-farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.1];"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" RELATED [EC:2.5.1.1];"dimethylallyltransferase activity" EXACT [];"diprenyltransferase activity" RELATED [EC:2.5.1.1];"DMAPP:IPP-dimethylallyltransferase activity" RELATED [EC:2.5.1.1];"geranyl diphosphate synthase activity" EXACT [];"geranyl pyrophosphate synthase activity" RELATED [EC:2.5.1.1];"geranyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1];"geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1];"trans-farnesyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1] WAS "(2E,6E)-farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.1];"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" RELATED [EC:2.5.1.1];"dimethylallyltransferase activity" EXACT [];"diprenyltransferase activity" RELATED [EC:2.5.1.1];"DMAPP:IPP-dimethylallyltransferase activity" RELATED [EC:2.5.1.1];"geranyl diphosphate synthase" EXACT [];"geranyl pyrophosphate synthase activity" RELATED [EC:2.5.1.1];"geranyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1];"geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1];"trans-farnesyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1] molecular_function GO:0004177 aminopeptidase activity definition "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] WAS "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] molecular_function GO:0004230 glutamyl aminopeptidase activity is_obsolete False WAS True name glutamyl aminopeptidase activity WAS obsolete glutamyl aminopeptidase activity definition "Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] WAS "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] comment N/A WAS This term was made obsolete because it represents a gene product. synonyms "aminopeptidase A" RELATED [EC:3.4.11.7];"angiotensinase A" RELATED [EC:3.4.11.7];"angiotensinase A2" RELATED [EC:3.4.11.7];"antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7];"aspartate aminopeptidase activity" RELATED [EC:3.4.11.7];"Ca2+-activated glutamate aminopeptidase activity" RELATED [EC:3.4.11.7];"glutamyl peptidase activity" RELATED [EC:3.4.11.7];"L-aspartate aminopeptidase activity" RELATED [EC:3.4.11.7];"membrane aminopeptidase II" RELATED [EC:3.4.11.7] WAS "aminopeptidase A" RELATED [EC:3.4.11.7];"angiotensinase A" RELATED [EC:3.4.11.7];"angiotensinase A2" RELATED [EC:3.4.11.7];"antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7];"aspartate aminopeptidase activity" RELATED [EC:3.4.11.7];"Ca2+-activated glutamate aminopeptidase activity" RELATED [EC:3.4.11.7];"glutamyl aminopeptidase activity" EXACT [];"glutamyl peptidase activity" RELATED [EC:3.4.11.7];"L-aspartate aminopeptidase activity" RELATED [EC:3.4.11.7];"membrane aminopeptidase II" RELATED [EC:3.4.11.7] molecular_function GO:0004311 geranylgeranyl diphosphate synthase activity name geranylgeranyl diphosphate synthase activity WAS farnesyltranstransferase activity synonyms "farnesyltranstransferase activity" EXACT [EC:2.5.1.29];"geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29];"geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29];"geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29];"geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29];"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" RELATED [EC:2.5.1.29] WAS "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29];"geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29];"geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29];"geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29];"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" RELATED [EC:2.5.1.29] molecular_function GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity name (2E,6E)-farnesyl diphosphate synthase activity WAS geranyltranstransferase activity synonyms "farnesyl diphosphate synthase activity" EXACT [];"farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.10];"farnesyl pyrophosphate synthetase activity" EXACT [];"farnesyl-diphosphate synthase activity" EXACT [];"farnesylpyrophosphate synthetase activity" RELATED [EC:2.5.1.10];"FPP synthetase activity" RELATED [EC:2.5.1.10];"geranyl transferase I" RELATED [EC:2.5.1.10];"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" RELATED [EC:2.5.1.10];"geranyltransferase activity" RELATED [EC:2.5.1.10];"geranyltranstransferase activity" EXACT [EC:2.5.1.10] WAS "farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.10];"farnesyl pyrophosphate synthetase activity" EXACT [];"farnesyl-diphosphate synthase activity" EXACT [];"farnesylpyrophosphate synthetase activity" RELATED [EC:2.5.1.10];"FPP synthetase activity" RELATED [EC:2.5.1.10];"geranyl transferase I" RELATED [EC:2.5.1.10];"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" RELATED [EC:2.5.1.10];"geranyltransferase activity" RELATED [EC:2.5.1.10] molecular_function GO:0004619 phosphoglycerate mutase activity synonyms "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity" NARROW [];"2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity" NARROW [];"D-phosphoglycerate 2,3-phosphomutase activity" RELATED [];"PGA mutase activity" RELATED [];"PGAM activity" RELATED [];"PGM" EXACT [];"phosphoglycerate phosphomutase activity" RELATED [];"phosphoglyceromutase activity" RELATED [] WAS "D-phosphoglycerate 2,3-phosphomutase activity" RELATED [];"PGA mutase activity" RELATED [];"PGAM activity" RELATED [];"PGM" EXACT [];"phosphoglycerate phosphomutase activity" RELATED [];"phosphoglyceromutase activity" RELATED [] molecular_function GO:0004779 sulfate adenylyltransferase activity definition "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah] WAS "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] molecular_function GO:0004883 nuclear glucocorticoid receptor activity definition "A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:17689856, PMID:20920967] WAS "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967] molecular_function GO:0008241 peptidyl-dipeptidase activity definition "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [EC:3.4.15.-, GOC:mb] WAS "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] molecular_function GO:0008412 4-hydroxybenzoate polyprenyltransferase activity synonyms "4-HB polyprenyltransferase activity" EXACT [];"4-hydroxybenzoate nonaprenyltransferase activity" NARROW [EC:2.5.1.39];"para-hydroxybenzoate transferase activity" EXACT [];"para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [];"para-hydroxybenzoate:polyprenyltransferase activity" EXACT [];"PHB polyprenyl diphosphate transferase activity" EXACT [] WAS "4-HB polyprenyltransferase activity" EXACT [];"para-hydroxybenzoate transferase activity" EXACT [];"para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [];"para-hydroxybenzoate:polyprenyltransferase activity" EXACT [];"PHB polyprenyl diphosphate transferase activity" EXACT [] molecular_function GO:0008709 cholate 7-alpha-dehydrogenase (NAD+) activity name cholate 7-alpha-dehydrogenase (NAD+) activity WAS cholate 7-alpha-dehydrogenase activity molecular_function GO:0008834 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity name ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity WAS di-trans,poly-cis-undecaprenyl-diphosphate synthase activity synonyms "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31];"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" RELATED [EC:2.5.1.31];"di-trans,poly-cis-decaprenylcistransferase activity" EXACT [];"di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31];"undecaprenyl diphosphate synthase activity" EXACT [];"undecaprenyl diphosphate synthetase activity" RELATED [EC:2.5.1.31];"undecaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.31];"undecaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.31];"undecaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31];"UPP synthetase activity" RELATED [EC:2.5.1.31] WAS "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31];"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" RELATED [EC:2.5.1.31];"di-trans,poly-cis-decaprenylcistransferase activity" EXACT [];"undecaprenyl diphosphate synthase activity" EXACT [];"undecaprenyl diphosphate synthetase activity" RELATED [EC:2.5.1.31];"undecaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.31];"undecaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.31];"undecaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31];"UPP synthetase activity" RELATED [EC:2.5.1.31] molecular_function GO:0010176 homogentisate phytyltransferase activity synonyms "HPT activity" EXACT [EC:2.5.1.115] WAS N/A molecular_function GO:0010356 homogentisate geranylgeranyltransferase activity synonyms "HGGT activity" EXACT [EC:2.5.1.116];"homogentisate geranylgeranyl transferase activity" EXACT [PMID:21223386] WAS "homogentisate geranylgeranyl transferase activity" EXACT [PMID:21223386] molecular_function GO:0010357 homogentisate solanesyltransferase activity synonyms "homogentisate solanyltransferase activity" EXACT [];"HST activity" EXACT [EC:2.5.1.117] WAS "homogentisate solanyltransferase activity" EXACT [] molecular_function GO:0016172 antifreeze activity is_obsolete False WAS True name antifreeze activity WAS obsolete antifreeze activity definition "Inhibits the growth and recrystallization of ice crystals, thereby lowering the freezing point of water and preventing cellular damage at subzero temperatures. This activity is observed in various cold-adapted organisms, including certain fish, insects, and plants, and contributes to survival in extreme cold environments by stabilizing supercooled liquid states." [GOC:cjm, PMID:33317024] WAS "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] comment Note that this term was reinstated from obsolete. WAS This term was made obsolete because it refers to a biological process. synonyms N/A WAS "antifreeze activity" EXACT [] molecular_function GO:0016285 alanyl aminopeptidase activity is_obsolete False WAS True name alanyl aminopeptidase activity WAS obsolete cytosol alanyl aminopeptidase activity definition "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] WAS "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] comment N/A WAS This term was made obsolete because it represents a gene product and refers to cellular component information. synonyms "aminopolypeptidase activity" BROAD [EC:3.4.11.14];"arylamidase activity" NARROW [EC:3.4.11.14];"cytosol alanyl aminopeptidase activity" EXACT [];"cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14];"human liver aminopeptidase" NARROW [EC:3.4.11.14];"liver aminopeptidase activity" NARROW [EC:3.4.11.14];"membrane alanine aminopeptidase" NARROW [];"membrane alanyl aminopeptidase" NARROW [];"puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14];"soluble alanyl aminopeptidase activity" RELATED [EC:3.4.11.14];"thiol-activated aminopeptidase activity" RELATED [EC:3.4.11.14] WAS "aminopolypeptidase activity" RELATED [EC:3.4.11.14];"arylamidase activity" NARROW [EC:3.4.11.14];"cytosol alanyl aminopeptidase activity" EXACT [];"cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14];"human liver aminopeptidase" NARROW [EC:3.4.11.14];"liver aminopeptidase activity" NARROW [EC:3.4.11.14];"puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14];"soluble alanyl aminopeptidase activity" RELATED [EC:3.4.11.14];"thiol-activated aminopeptidase activity" RELATED [EC:3.4.11.14] molecular_function GO:0016664 oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor definition "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [EC:1.7.7.-] WAS "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] molecular_function GO:0016805 dipeptidase activity definition "Catalysis of the hydrolysis of a dipeptide." [EC:3.4.13.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002] WAS "Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002] molecular_function GO:0019833 ice nucleation activity is_obsolete False WAS True name ice nucleation activity WAS obsolete ice nucleation activity definition "Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees Celsius) to protect the organism from damage by intracellular ice formation. This process is commonly found in certain bacteria, such as Pseudomonas syringae, and plays roles in environmental adaptation and plant pathogenesis." [GOC:cjm, PMID:35551271, UniProt:KW-0387] WAS "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins comment Note that this term was reinstated from obsolete. WAS This term was made obsolete because it represents a biological process. synonyms N/A WAS "ice nucleation activity" EXACT [] molecular_function GO:0030284 nuclear estrogen receptor activity definition "A nuclear receptor activity regulated by estrogen binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:signaling, PMID:17615392] WAS "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392] molecular_function GO:0031963 nuclear cortisol receptor activity definition "A nuclear receptor activity regulated by cortisol binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:mah, PMID:12511169] WAS "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:mah, PMID:12511169] molecular_function GO:0033782 24S-hydroxycholesterol 7alpha-hydroxylase activity name 24S-hydroxycholesterol 7alpha-hydroxylase activity WAS 24-hydroxycholesterol 7alpha-hydroxylase activity synonyms "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [];"24-hydroxycholesterol 7alpha-hydroxylase activity" BROAD [];"24-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.26] WAS "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [];"24-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.26] molecular_function GO:0036423 hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity synonyms "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83];"hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83];"HexPS activity" EXACT [EC:2.5.1.83] WAS "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83];"hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83] molecular_function GO:0038186 bile acid nuclear receptor activity definition "A nuclear receptor activity regulated by a bile acid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II." [PMID:32480317, PMID:35415765, PMID:36409000] WAS "A DNA-binding transcription factor activity regulated by binding to a bile acid that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [PMID:32480317, PMID:35415765, PMID:36409000] molecular_function GO:0044687 geranylfarnesyl diphosphate synthase activity synonyms "FGPP synthase activity" EXACT [EC:2.5.1.81] WAS N/A molecular_function GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity name ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity WAS dehydrodolichyl diphosphate synthase activity definition "Catalysis of the reaction WAS "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] synonyms "dehydrodolichyl diphosphate synthase activity" EXACT [EC:2.5.1.87] WAS N/A molecular_function GO:0046562 beta-D-glucose oxidase activity name beta-D-glucose oxidase activity WAS glucose oxidase activity synonyms "beta-D-glucose:oxygen 1-oxido-reductase activity" RELATED [EC:1.1.3.4];"beta-D-glucose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.4];"beta-D-glucose:quinone oxidoreductase activity" RELATED [EC:1.1.3.4];"corylophyline" RELATED [EC:1.1.3.4];"D-glucose oxidase activity" RELATED [EC:1.1.3.4];"D-glucose-1-oxidase activity" RELATED [EC:1.1.3.4];"deoxin-1" RELATED [EC:1.1.3.4];"glucose aerodehydrogenase activity" RELATED [EC:1.1.3.4];"glucose oxidase activity" EXACT [];"glucose oxyhydrase activity" RELATED [EC:1.1.3.4];"GOD activity" RELATED [EC:1.1.3.4];"microcid" RELATED [EC:1.1.3.4];"penatin" RELATED [EC:1.1.3.4] WAS "beta-D-glucose oxidase activity" EXACT [];"beta-D-glucose:oxygen 1-oxido-reductase activity" RELATED [EC:1.1.3.4];"beta-D-glucose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.4];"beta-D-glucose:quinone oxidoreductase activity" RELATED [EC:1.1.3.4];"corylophyline" RELATED [EC:1.1.3.4];"D-glucose oxidase activity" RELATED [EC:1.1.3.4];"D-glucose-1-oxidase activity" RELATED [EC:1.1.3.4];"deoxin-1" RELATED [EC:1.1.3.4];"glucose aerodehydrogenase activity" RELATED [EC:1.1.3.4];"glucose oxyhydrase activity" RELATED [EC:1.1.3.4];"GOD activity" RELATED [EC:1.1.3.4];"microcid" RELATED [EC:1.1.3.4];"penatin" RELATED [EC:1.1.3.4] molecular_function GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity name 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity WAS 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity synonyms "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity" EXACT [];"20alpha-HSD" RELATED [EC:1.1.1.149];"20alpha-HSDH" RELATED [EC:1.1.1.149];"20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149];"20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149];"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149] WAS "20alpha-HSD" RELATED [EC:1.1.1.149];"20alpha-HSDH" RELATED [EC:1.1.1.149];"20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149];"20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149];"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149] molecular_function GO:0047023 androsterone dehydrogenase [NAD(P)+] activity name androsterone dehydrogenase [NAD(P)+] activity WAS androsterone dehydrogenase activity molecular_function GO:0047024 5-alpha-androstane-3beta,17beta-diol dehydrogenase (NADP+) activity name 5-alpha-androstane-3beta,17beta-diol dehydrogenase (NADP+) activity WAS 5alpha-androstane-3beta,17beta-diol dehydrogenase activity synonyms "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210];"3-beta-HSD activity" RELATED [EC:1.1.1.210];"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210];"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210];"3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210];"5alpha-androstane-3beta,17beta-diol dehydrogenase activity" EXACT [];"dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210];"progesterone reductase activity" RELATED [EC:1.1.1.210] WAS "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210];"3-beta-HSD activity" RELATED [EC:1.1.1.210];"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210];"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210];"3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210];"dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210];"progesterone reductase activity" RELATED [EC:1.1.1.210] molecular_function GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity name androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity WAS androstan-3-alpha,17-beta-diol dehydrogenase activity molecular_function GO:0047294 phosphoglycerol geranylgeranyltransferase activity synonyms "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity" EXACT [];"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41];"geranylgeranyl-transferase activity" RELATED [EC:2.5.1.41];"GGGP synthase activity" EXACT [EC:2.5.1.41];"GGGPS activity" EXACT [EC:2.5.1.41];"glycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41] WAS "(S)-3-O-geranylgeranylglyceryl phosphate synthase activity" EXACT [];"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41];"geranylgeranyl-transferase activity" RELATED [EC:2.5.1.41];"glycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41] molecular_function GO:0047295 geranylgeranylglycerol-phosphate geranylgeranyltransferase activity synonyms "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity" EXACT [];"DGGGP synthase activity" EXACT [EC:2.5.1.42];"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42];"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42];"geranylgeranyltransferase II" RELATED [EC:2.5.1.42] WAS "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity" EXACT [];"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42];"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42];"geranylgeranyltransferase II" RELATED [EC:2.5.1.42] molecular_function GO:0047521 12-beta-hydroxysteroid dehydrogenase (NADP+) activity name 12-beta-hydroxysteroid dehydrogenase (NADP+) activity WAS 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity synonyms "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238];"12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238];"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238];"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity" BROAD [EC:1.1.1.238] WAS "12-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238];"12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238];"12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238];"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238] molecular_function GO:0047791 cucurbitacin Delta23 reductase [NAD(P)H] activity name cucurbitacin Delta23 reductase [NAD(P)H] activity WAS cucurbitacin delta23-reductase activity molecular_function GO:0050613 Delta14-sterol reductase activity name Delta14-sterol reductase activity WAS delta14-sterol reductase activity molecular_function GO:0050614 Delta24-sterol reductase activity name Delta24-sterol reductase activity WAS delta24-sterol reductase activity molecular_function GO:0050825 ice binding synonyms "ice crystal binding" EXACT [];"ice nucleation inhibitor activity" RELATED [] WAS "antifreeze activity" RELATED [];"ice crystal binding" EXACT [];"ice nucleation activity" RELATED [];"ice nucleation inhibitor activity" RELATED [] molecular_function GO:0051996 squalene synthase [NAD(P)H] activity synonyms "farnesyl-diphosphate farnesyltransferase activity" NARROW [EC:2.5.1.21];"farnesyltransferase activity" BROAD [EC:2.5.1.21];"presqualene synthase activity" EXACT [EC:2.5.1.21];"presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21];"squalene synthase activity" EXACT [EC:2.5.1.21];"squalene synthetase activity" RELATED [EC:2.5.1.21] WAS "squalene synthetase activity" RELATED [EC:2.5.1.21] molecular_function GO:0052849 curcumin reductase (NADP+) activity name curcumin reductase (NADP+) activity WAS NADPH-dependent curcumin reductase activity synonyms "NADPH-dependent curcumin reductase activity" EXACT [] WAS N/A molecular_function GO:0061776 ATP-dependent topological DNA co-entrapment activity name ATP-dependent topological DNA co-entrapment activity WAS topological DNA co-entrapment activity synonyms "ATP-dependent ring closure activity" EXACT [];"topological DNA entrapment activity" RELATED [] WAS "topological DNA entrapment activity" RELATED [] molecular_function GO:0097269 all-trans-decaprenyl-diphosphate synthase activity synonyms "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [];"2-trans,6-trans-farnesyl diphosphate activity" EXACT [];"decaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.91];"decaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.91];"polyprenylpyrophosphate synthetase activity" BROAD [EC:2.5.1.91];"terpenoidallyltransferase activity" BROAD [EC:2.5.1.91];"terpenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.91];"trans-prenyltransferase activity" BROAD [EC:2.5.1.91] WAS "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [];"2-trans,6-trans-farnesyl diphosphate activity" EXACT [] molecular_function GO:0098531 ligand-modulated transcription factor activity name ligand-modulated transcription factor activity WAS ligand-activated transcription factor activity synonyms "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT [];"ligand-activated transcription factor activity" NARROW [];"transcription factor activity, direct ligand regulated sequence-specific DNA binding" EXACT [] WAS "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT [];"transcription factor activity, direct ligand regulated sequence-specific DNA binding" EXACT [] molecular_function GO:0102059 (2Z,6Z)-farnesyl diphosphate synthase activity name (2Z,6Z)-farnesyl diphosphate synthase activity WAS 2-cis,6-cis-farnesyl pyrophosphate synthase activity synonyms "2-cis,6-cis-farnesyl pyrophosphate synthase activity" EXACT [];"cis,cis-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.92];"neryl-diphosphate:isopentenyl-diphosphate cistransferase activity" NARROW [];"Z,Z-farnesyl pyrophosphate synthase activity" EXACT [EC:2.5.1.92];"Z,Z-FPP synthase activity" EXACT [EC:2.5.1.92];"zFPS activity" EXACT [EC:2.5.1.92] WAS "neryl-diphosphate:isopentenyl-diphosphate cistransferase activity" NARROW [] molecular_function GO:0102175 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase (NAD+) activity name 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase (NAD+) activity WAS 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity molecular_function GO:0102191 3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity name 3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity WAS 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity synonyms "3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity" EXACT [];"4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity" EXACT [] WAS "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity" EXACT [] molecular_function GO:0103031 L-Ala-D/L-Glu epimerase activity definition "Catalysis of the reaction:L-alanyl-L-glutamate = L-alanyl-D-glutamate." [RHEA:28394] WAS "Catalysis of the reaction molecular_function GO:0106350 all-trans-octaprenyl-diphosphate synthase activity name all-trans-octaprenyl-diphosphate synthase activity WAS octaprenyl pyrophosphate synthase activity synonyms "octaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.90];"terpenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.90];"trans-heptaprenyltranstransferase activity" EXACT [EC:2.5.1.90];"trans-prenyltransferase activity" BROAD [EC:2.5.1.90] WAS N/A molecular_function GO:0141096 ligand-modulated transcription repressor activity name ligand-modulated transcription repressor activity WAS ligand-activated transcription repressor activity synonyms "ligand-activated transcription repressor activity" NARROW [] WAS N/A molecular_function GO:0141097 ligand-modulated transcription activator activity name ligand-modulated transcription activator activity WAS ligand-activated transcription activator activity synonyms "ligand-activated transcription activator activity" NARROW [] WAS N/A biological_process GO:0001824 blastocyst development definition "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771] WAS "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] synonyms "blastula development" RELATED [] WAS N/A biological_process GO:0001825 blastocyst formation synonyms "blastula formation" RELATED [] WAS N/A biological_process GO:0001832 blastocyst growth synonyms "blastula growth" RELATED [] WAS N/A biological_process GO:0001835 blastocyst hatching synonyms "blastula hatching" RELATED [] WAS N/A biological_process GO:0006601 creatine biosynthetic process definition "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [GOC:mah, MetaCyc:GLYCGREAT-PWY] WAS "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] biological_process GO:0006675 mannosyl-inositol phosphorylceramide metabolic process definition "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] WAS "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] biological_process GO:0008153 4-aminobenzoate biosynthetic process name 4-aminobenzoate biosynthetic process WAS para-aminobenzoic acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] WAS "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] synonyms "4-aminobenzoic acid biosynthesis" EXACT [];"4-aminobenzoic acid biosynthetic process" EXACT [];"p-aminobenzoic acid biosynthesis" EXACT [];"p-aminobenzoic acid biosynthetic process" EXACT [];"PABA biosynthesis" EXACT [];"PABA biosynthetic process" EXACT [];"para-aminobenzoic acid anabolism" EXACT [];"para-aminobenzoic acid biosynthesis" EXACT [];"para-aminobenzoic acid biosynthetic process" EXACT [];"para-aminobenzoic acid formation" EXACT [];"para-aminobenzoic acid synthesis" EXACT [];"vitamin Bx biosynthesis" EXACT [];"vitamin Bx biosynthetic process" EXACT [] WAS "4-aminobenzoic acid biosynthesis" EXACT [];"4-aminobenzoic acid biosynthetic process" EXACT [];"p-aminobenzoic acid biosynthesis" EXACT [];"p-aminobenzoic acid biosynthetic process" EXACT [];"PABA biosynthesis" EXACT [];"PABA biosynthetic process" EXACT [];"para-aminobenzoic acid anabolism" EXACT [];"para-aminobenzoic acid biosynthesis" EXACT [];"para-aminobenzoic acid formation" EXACT [];"para-aminobenzoic acid synthesis" EXACT [];"vitamin Bx biosynthesis" EXACT [];"vitamin Bx biosynthetic process" EXACT [] biological_process GO:0009626 plant-type hypersensitive response comment Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185. WAS Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. biological_process GO:0010134 sulfate assimilation via adenylyl sulfate reduction definition "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [MetaCyc:SULFMETII-PWY] WAS "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] biological_process GO:0018868 2-aminobenzenesulfonate metabolic process definition "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:curators] WAS "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] biological_process GO:0018873 atrazine metabolic process definition "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [GOC:curators] WAS "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr] biological_process GO:0018882 (+)-camphor metabolic process definition "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [GOC:curators] WAS "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam] biological_process GO:0018901 2,4-dichlorophenoxyacetic acid metabolic process definition "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:curators] WAS "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] biological_process GO:0018952 parathion metabolic process definition "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [GOC:curators] WAS "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] biological_process GO:0018970 toluene metabolic process definition "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [GOC:curators] WAS "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [UM-BBD_pathwayID:tol] biological_process GO:0018983 Z-phenylacetaldoxime metabolic process definition "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:pao] WAS "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car] biological_process GO:0019087 symbiont-mediated transformation of host cell name symbiont-mediated transformation of host cell WAS transformation of host cell by virus definition "A symbiont-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. Usually mediated by viruses." [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315] WAS "A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication." [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315] synonyms "host cell immortalization" EXACT [];"host cell transformation" EXACT [];"immortalization of host cell" EXACT [];"immortalization of host cell by virus" RELATED [];"transformation of host cell" EXACT [];"transformation of host cell by virus" EXACT [];"viral immortalization" EXACT [];"viral transformation" EXACT [];"viral transformation of host cell" EXACT [];"virus-mediated transformation of host cell" RELATED [] WAS "host cell immortalization" EXACT [];"host cell transformation" EXACT [];"immortalization of host cell" EXACT [];"immortalization of host cell by virus" RELATED [];"transformation of host cell" EXACT [];"viral immortalization" EXACT [];"viral transformation" EXACT [];"viral transformation of host cell" EXACT [] biological_process GO:0019329 ammonia oxidation definition "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah] WAS "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] biological_process GO:0019339 parathion catabolic process definition "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [MetaCyc:PARATHION-DEGRADATION-PWY] WAS "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] biological_process GO:0019381 atrazine catabolic process definition "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, MetaCyc:PWY-5724] WAS "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, UM-BBD_pathwayID:atr] biological_process GO:0019383 (+)-camphor catabolic process definition "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [MetaCyc:P601-PWY] WAS "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [UM-BBD_pathwayID:cam] biological_process GO:0019417 sulfur oxidation definition "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl] WAS "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] biological_process GO:0019434 sophorosyloxydocosanoate metabolic process definition "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [GOC:curators] WAS "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] biological_process GO:0019490 2-aminobenzenesulfonate desulfonation definition "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [MetaCyc:2ASDEG-PWY] WAS "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] biological_process GO:0019517 L-threonine catabolic process to D-lactate definition "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:THRDLCTCAT-PWY] WAS "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY] biological_process GO:0019662 non-glycolytic fermentation definition "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl] WAS "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] biological_process GO:0019665 anaerobic amino acid catabolic process definition "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl] WAS "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] biological_process GO:0033108 mitochondrial respiratory chain complex assembly definition "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures." [GOC:mah] WAS "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] biological_process GO:0033302 quercetin O-glucoside metabolic process definition "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah] WAS "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] biological_process GO:0033321 homomethionine metabolic process definition "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah] WAS "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] biological_process GO:0033322 L-homomethionine biosynthetic process name L-homomethionine biosynthetic process WAS homomethionine biosynthetic process definition "The chemical reactions and pathways resulting in the formation of L-homomethionine, a non-protein amino acid synthesized from L-methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] WAS "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonyms "homomethionine anabolism" EXACT [];"homomethionine biosynthesis" EXACT [];"homomethionine biosynthetic process" EXACT [];"homomethionine formation" EXACT [];"homomethionine synthesis" EXACT [] WAS "homomethionine anabolism" EXACT [];"homomethionine biosynthesis" EXACT [];"homomethionine formation" EXACT [];"homomethionine synthesis" EXACT [] biological_process GO:0033329 kaempferol O-glucoside metabolic process definition "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah] WAS "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] biological_process GO:0033331 ent-kaurene metabolic process definition "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, PMID:17064690] WAS "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] biological_process GO:0033359 lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate definition "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY] WAS "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-] biological_process GO:0033383 geranyl diphosphate metabolic process definition "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah] WAS "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] biological_process GO:0033385 geranylgeranyl diphosphate metabolic process definition "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah] WAS "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] biological_process GO:0033386 geranylgeranyl diphosphate biosynthetic process definition "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah] WAS "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120] biological_process GO:0033387 putrescine biosynthetic process from arginine, via ornithine name putrescine biosynthetic process from arginine, via ornithine WAS putrescine biosynthetic process from ornithine definition "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine, via decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] WAS "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] synonyms "putrescine anabolism from ornithine" EXACT [];"putrescine biosynthesis from ornithine" EXACT [];"putrescine biosynthetic process from ornithine" EXACT [];"putrescine formation from ornithine" EXACT [];"putrescine synthesis from ornithine" EXACT [] WAS "putrescine anabolism from ornithine" EXACT [];"putrescine biosynthesis from ornithine" EXACT [];"putrescine formation from ornithine" EXACT [];"putrescine synthesis from ornithine" EXACT [] biological_process GO:0033388 putrescine biosynthetic process from arginine definition "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah] WAS "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46] biological_process GO:0033389 putrescine biosynthetic process from arginine, via agmatine name putrescine biosynthetic process from arginine, via agmatine WAS putrescine biosynthetic process from arginine, using agmatinase definition "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine via agmatine." [GOC:mah, MetaCyc:PWY-40] WAS "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40] synonyms "putrescine anabolism from arginine, using agmatinase" EXACT [];"putrescine biosynthesis from arginine, using agmatinase" EXACT [];"putrescine biosynthetic process from arginine, using agmatinase" EXACT [];"putrescine formation from arginine, using agmatinase" EXACT [];"putrescine synthesis from arginine, using agmatinase" EXACT [] WAS "putrescine anabolism from arginine, using agmatinase" EXACT [];"putrescine biosynthesis from arginine, using agmatinase" EXACT [];"putrescine formation from arginine, using agmatinase" EXACT [];"putrescine synthesis from arginine, using agmatinase" EXACT [] biological_process GO:0033499 galactose catabolic process via UDP-galactose definition "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah] WAS "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821] biological_process GO:0034055 effector-mediated activation of host programmed cell death by symbiont name effector-mediated activation of host programmed cell death by symbiont WAS effector-mediated activation of programmed cell death in host synonyms "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"effector-mediated activation of programmed cell death in host" EXACT [];"effector-mediated induction of programmed cell death in host" EXACT [];"enhancement by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators];"positive regulation by symbiont of host defense-related programmed cell death" RELATED [];"stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators];"up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators];"upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] WAS "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"effector-mediated induction of programmed cell death in host" EXACT [];"enhancement by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators];"positive regulation by symbiont of host defense-related programmed cell death" RELATED [];"stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators];"up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators];"up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators];"upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] biological_process GO:0034077 butanediol metabolic process definition "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123] WAS "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL] biological_process GO:0034078 butanediol catabolic process definition "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123] WAS "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] biological_process GO:0034079 butanediol biosynthetic process definition "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:P125-PWY] WAS "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY] biological_process GO:0039520 symbiont-mediated activation of host autophagy name symbiont-mediated activation of host autophagy WAS induction by virus of host autophagy definition "A process in which a symbiont initiates, promotes, or enhances the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. For example, some viruses are able to activate host autophagy as a cellular survival mechanism, hence delaying or inhibiting apoptosis." [GOC:bf, GOC:sp, VZ:846] WAS "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846] synonyms "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072];"autophagy of host cells involved in interaction with symbiont" RELATED [];"induction by virus of host autophagy" NARROW [];"positive regulation by virus of host autophagy" BROAD [GOC:bf] WAS "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072];"autophagy of host cells involved in interaction with symbiont" RELATED [];"positive regulation by virus of host autophagy" BROAD [GOC:bf] biological_process GO:0039522 symbiont-mediated suppression of host mRNA export from nucleus definition "A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:22334672] WAS "A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp] biological_process GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity name symbiont-mediated-mediated suppression of host tetherin activity WAS suppression by virus of host tetherin activity definition "Any process in which a symbiont stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439] WAS "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439] synonyms "evasion of suppression of viral release by host via inhibition of host tetherin activity" NARROW [];"inhibition of host BST2/Tetherin by virus" EXACT [];"suppression by virus of host tetherin activity" EXACT [] WAS "inhibition of host BST2/Tetherin by virus" EXACT [] biological_process GO:0039635 symbiont-mediated suppression of host peptidoglycan biosynthetic process name symbiont-mediated suppression of host peptidoglycan biosynthetic process WAS suppression by virus of host peptidoglycan biosynthetic process synonyms "suppression by virus of host peptidoglycan biosynthetic process" NARROW [];"viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf] WAS "viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf] biological_process GO:0039636 symbiont-mediated suppression of host cell wall biogenesis name symbiont-mediated suppression of host cell wall biogenesis WAS suppression by virus of host cell wall biogenesis synonyms "suppression by virus of host cell wall biogenesis" NARROW [] WAS N/A biological_process GO:0039671 symbiont-mediated perturbation of host natural killer cell mediated immune response name symbiont-mediated perturbation of host natural killer cell mediated immune response WAS evasion by virus of host natural killer cell activity definition "A process in which a symbiont alters or subverts the natural killer cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131] WAS "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131] synonyms "evasion by virus of host natural killer cell activity" NARROW [];"evasion by virus of host natural killer cell response" EXACT [];"evasion by virus of host NK cell killing" EXACT [GOC:bf];"modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131];"protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710];"suppression by virus of host natural killer cell function" NARROW [PMID:15640804];"viral immunoevasion of host NK cell" NARROW [GOC:bf] WAS "evasion by virus of host natural killer cell response" EXACT [];"evasion by virus of host NK cell killing" EXACT [GOC:bf];"modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131];"protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710];"suppression by virus of host natural killer cell function" EXACT [PMID:15640804];"viral immunoevasion of host NK cell" EXACT [GOC:bf] biological_process GO:0039672 symbiont-mediated suppression of host natural killer cell activation name symbiont-mediated suppression of host natural killer cell activation WAS suppression by virus of host natural killer cell activation definition "A process in which a symbiont interferes with, inhibits or disrupts natural killer cell activation in the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:10799855] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host." [GOC:bf, GOC:jl] synonyms "suppression by virus of host natural killer cell activation" NARROW [];"suppression by virus of host NK-cell activation" EXACT [] WAS "suppression by virus of host NK-cell activation" EXACT [GOC:bf, GOC:jl] biological_process GO:0039673 symbiont-mediated suppression of host dendritic cell mediated immune response name symbiont-mediated suppression of host dendritic cell mediated immune response WAS evasion by virus of host dendritic cell activity definition "A process in which a symbiont inhibits or disrupts the dendritic cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118] WAS "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118] synonyms "evasion by virus of host dendritic cell activity" RELATED [];"evasion by virus of host dendritic cell response" EXACT [];"impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118];"modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118] WAS "evasion by virus of host dendritic cell response" EXACT [];"impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118];"modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118] biological_process GO:0042199 cyanuric acid metabolic process definition "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [GOC:curators] WAS "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya] biological_process GO:0042201 N-cyclopropylmelamine metabolic process definition "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [GOC:curators] WAS "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [UM-BBD_pathwayID:cpm] biological_process GO:0042203 toluene catabolic process definition "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [UM-BBD_pathwayID:tol] WAS "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators] biological_process GO:0042212 cresol metabolic process definition "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:curators] WAS "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [UM-BBD_pathwayID:mcr] biological_process GO:0042783 symbiont-mediated evasion of host immune response name symbiont-mediated evasion of host immune response WAS evasion of host immune response synonyms "active evasion of host immune response" RELATED [];"active evasion of immune response of other organism involved in symbiotic interaction" BROAD [];"active immune evasion" BROAD [];"evasion by virus of host immune response" RELATED [];"evasion of host immune response" EXACT [];"evasion or tolerance of host immune response" BROAD [];"immune evasion" EXACT [];"mitigation by virus of host immune response" RELATED [];"mitigation of host immune response" RELATED [];"mitigation of host immune response by virus" RELATED [];"passive evasion of host immune response" RELATED [];"passive evasion of immune response of other organism involved in symbiotic interaction" RELATED [];"passive immune evasion" RELATED [];"suppression by virus of host immune response" RELATED [] WAS "active evasion of host immune response" RELATED [];"active evasion of immune response of other organism involved in symbiotic interaction" BROAD [];"active immune evasion" BROAD [];"evasion by virus of host immune response" RELATED [];"evasion or tolerance of host immune response" BROAD [];"immune evasion" EXACT [];"mitigation by virus of host immune response" RELATED [];"mitigation of host immune response" RELATED [];"mitigation of host immune response by virus" RELATED [];"passive evasion of host immune response" RELATED [];"passive evasion of immune response of other organism involved in symbiotic interaction" RELATED [];"passive immune evasion" RELATED [];"suppression by virus of host immune response" RELATED [] biological_process GO:0043039 tRNA aminoacylation definition "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah] WAS "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] biological_process GO:0044865 symbiont-mediated suppression of host cell division name symbiont-mediated suppression of host cell division WAS negative regulation by virus of host cell division definition "A process in which a symbiont inhibits or disrupts the normal execution of cell division in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24218612] WAS "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division." [GOC:jl] synonyms "inhibition by virus of host cell division" NARROW [];"negative regulation by virus of host cell division" NARROW [] WAS "inhibition by virus of host cell division" NARROW [] biological_process GO:0046300 2,4-dichlorophenoxyacetic acid catabolic process definition "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai, UM-BBD_pathwayID:2\,4-d] WAS "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] biological_process GO:0046494 rhizobactin 1021 metabolic process definition "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [PMID:11274118] WAS "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] biological_process GO:0046499 S-adenosylmethioninamine metabolic process definition "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah] WAS "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] biological_process GO:0046597 blocking of symbiont entry into host cell name blocking of symbiont entry into host cell WAS negative regulation of viral entry into host cell definition "A process in which a host inhibits or disrupts the entry of a symbiont into a host cell." [PMID:23544079] WAS "Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell." [GOC:jl] synonyms "negative regulation of symbiont entry into host cell" RELATED [];"negative regulation of viral entry into host cell" NARROW [];"negative regulation of viral penetration into host cell" EXACT [];"prevention of symbiont entry into host cell" EXACT [] WAS "negative regulation of viral penetration into host cell" EXACT [] biological_process GO:0051504 diterpene phytoalexin precursor biosynthetic process name diterpene phytoalexin precursor biosynthetic process WAS diterpene phytoalexin precursor biosynthetic process pathway biological_process GO:0052081 symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway definition "A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:35698792] WAS "A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] biological_process GO:0052088 symbiont-mediated perturbation of host jasmonic acid signaling name symbiont-mediated perturbation of host jasmonic acid signaling WAS symbiont defense to host-produced jasmonic acid definition "A process in which a symbiont alters or subverts a jasmonic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:29222513, PMID:35698792] WAS "Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"down regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"down-regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"downregulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [];"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"modulation by organism of host JA-mediated defense response" NARROW [];"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [];"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [];"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"negative regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"suppression by organism of host JA-mediated defense response" EXACT [];"suppression by symbiont of host jasmonic acid-mediated defense response" RELATED [];"symbiont defense to host-produced jasmonic acid" EXACT [];"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] WAS "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"down regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"down-regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"downregulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [];"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"modulation by organism of host JA-mediated defense response" NARROW [];"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [];"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [];"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"negative regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [];"positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [];"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"suppression by organism of host JA-mediated defense response" EXACT [];"suppression by symbiont of host jasmonic acid-mediated defense response" RELATED [];"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [];"upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [];"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] biological_process GO:0052151 symbiont-mediated activation of host apoptosis definition "A process in which a symbiont initiates, promotes, or enhances the normal execution of host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981] WAS "A process in which a symbiont gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981] biological_process GO:0052158 symbiont-mediated perturbation of host resistance gene-dependent defense response name symbiont-mediated perturbation of host resistance gene-dependent defense response WAS modulation by symbiont of host resistance gene-dependent defense response synonyms "modulation by organism of defense response in host by specific elicitors" EXACT [];"modulation by organism of host gene-for-gene resistance" EXACT [];"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [];"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [];"modulation by symbiont of host resistance gene-dependent defense response" EXACT [] WAS "modulation by organism of defense response in host by specific elicitors" EXACT [];"modulation by organism of host gene-for-gene resistance" EXACT [];"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [];"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [] biological_process GO:0052165 symbiont-mediated perturbation of host phytoalexin production name symbiont-mediated perturbation of host phytoalexin production WAS symbiont defense to host-produced phytoalexin definition "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:6870275] WAS "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "evasion or tolerance by symbiont of host-produced phytoalexins" EXACT [];"evasion or tolerance of phytoalexins" EXACT [];"evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [];"host phytoalexin detoxification" NARROW [];"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction" NARROW [];"modulation by symbiont of host phytoalexin production" NARROW [];"phytoalexin detoxification" NARROW [];"response to host phytoalexin production" BROAD [];"response to phytoalexin production by other organism involved in symbiotic interaction" BROAD [];"symbiont defense to host-produced phytoalexin" EXACT [] WAS "evasion or tolerance by symbiont of host-produced phytoalexins" EXACT [];"evasion or tolerance of phytoalexins" EXACT [];"evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [];"host phytoalexin detoxification" NARROW [];"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction" NARROW [];"modulation by symbiont of host phytoalexin production" NARROW [];"phytoalexin detoxification" NARROW [];"response to host phytoalexin production" BROAD [];"response to phytoalexin production by other organism involved in symbiotic interaction" BROAD [] biological_process GO:0052200 symbiont-mediated response to host defenses name symbiont-mediated response to host defenses WAS response to host defenses synonyms "maintenance of symbiont tolerance to host defense molecules" NARROW [];"response of symbiont to host defense molecules" NARROW [];"response to host defense molecules" NARROW [];"response to host defenses" EXACT [] WAS "maintenance of symbiont tolerance to host defense molecules" NARROW [];"response of symbiont to host defense molecules" NARROW [];"response to host defense molecules" NARROW [] biological_process GO:0052315 phytoalexin biosynthetic process definition "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [PMID:22209038, PMID:3882051, Wikipedia:Phytoalexin] WAS "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] biological_process GO:0052776 chitin catabolic process to fructose 6-phosphate via glucosamine name chitin catabolic process to fructose 6-phosphate via glucosamine WAS diacetylchitobiose catabolic process to glucosamine and acetate definition "The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587] WAS "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587] synonyms "diacetylchitobiose catabolic process to glucosamine and acetate" EXACT [] WAS N/A biological_process GO:0061681 Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate definition "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, PMID:12921536] WAS "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536] biological_process GO:0097250 mitochondrial respirasome assembly definition "The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex." [PMID:30030361, PMID:32311046] WAS "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701] biological_process GO:0097294 'de novo' XMP biosynthetic process definition "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [GOC:yaf, PMID:27590927] WAS "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927] biological_process GO:0140415 effector-mediated perturbation of host defenses by symbiont name effector-mediated perturbation of host defenses by symbiont WAS effector-mediated modulation of host defenses by symbiont synonyms "effector-mediated modulation of host defenses by symbiont" EXACT [] WAS N/A biological_process GO:0140418 effector-mediated perturbation of host process by symbiont name effector-mediated perturbation of host process by symbiont WAS effector-mediated modulation of host process by symbiont synonyms "effector mediated modulation of host process by symbiont" EXACT [];"effector triggered modulation of host process by symbiont" EXACT [];"effector-dependent modulation of host process by symbiont" EXACT [];"effector-mediated modulation of host process by symbiont" EXACT [] WAS "effector mediated modulation of host process by symbiont" EXACT [];"effector triggered modulation of host process by symbiont" EXACT [];"effector-dependent modulation of host process by symbiont" EXACT [] biological_process GO:0140645 neutrophil extracellular trap formation name neutrophil extracellular trap formation WAS neutrophic extracellular trap formation biological_process GO:0140883 symbiont-mediated activation of host reticulophagy name symbiont-mediated activation of host reticulophagy WAS induction by virus of host reticulophagy definition "A process in which a symbiont initiates, promotes, or enhances the normal execution of host reticulophagy, leading to an increase in the frequency, rate or extent of reticulophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:35239449] WAS "Any process in which a virus activates or increases the frequency, rate or extent of reticulophagy in the host." [PMID:35239449] synonyms "activation of host reticulophagy by virus" EXACT [];"induction by virus of host reticulophagy" NARROW [];"positive regulation by virus of host reticulophagy" BROAD [] WAS "activation of host reticulophagy by virus" EXACT [];"positive regulation by virus of host reticulophagy" BROAD [] biological_process GO:0140976 host defense response against symbiont-mediated perturbation of plasma membrane integrity name host defense response against symbiont-mediated perturbation of plasma membrane integrity WAS defense response against perturbation of plasma membrane integrity synonyms "defense response against disruption of plasma membrane integrity" EXACT [];"defense response against perturbation of plasma membrane integrity" RELATED [] WAS "defense response against disruption of plasma membrane integrity" EXACT [] biological_process GO:0141154 symbiont-mediated suppression of host-directed shutoff of host translation definition "A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20563710, PMID:21622569] WAS "A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg] biological_process GO:0160164 negative regulation of chromatin looping name negative regulation of chromatin looping WAS negative regulation of chromatin loopin biological_process GO:1901790 3-(2,3-dihydroxyphenyl)propanoate metabolic process definition "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf] WAS "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:HCAMHPDEG-PWY] biological_process GO:1901807 capsanthin metabolic process definition "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806] WAS "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] biological_process GO:1901808 capsanthin catabolic process definition "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806] WAS "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] biological_process GO:1901824 alpha-carotene biosynthetic process name alpha-carotene biosynthetic process WAS delta-carotene biosynthetic process definition "The chemical reactions and pathways resulting in the formation of alpha-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] WAS "The chemical reactions and pathways resulting in the formation of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] synonyms "delta-carotene anabolism" EXACT [GOC:TermGenie];"delta-carotene biosynthesis" EXACT [GOC:TermGenie];"delta-carotene biosynthetic process" EXACT [];"delta-carotene formation" EXACT [GOC:TermGenie];"delta-carotene synthesis" EXACT [GOC:TermGenie] WAS "delta-carotene anabolism" EXACT [GOC:TermGenie];"delta-carotene biosynthesis" EXACT [GOC:TermGenie];"delta-carotene formation" EXACT [GOC:TermGenie];"delta-carotene synthesis" EXACT [GOC:TermGenie] biological_process GO:1901833 neoxanthin biosynthetic process name neoxanthin biosynthetic process WAS all-trans-neoxanthin biosynthetic process definition "The chemical reactions and pathways resulting in the formation of trans-neoxanthin and 9'-cis-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] WAS "The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] synonyms "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie];"all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie];"all-trans-neoxanthin biosynthetic process" NARROW [];"all-trans-neoxanthin formation" EXACT [GOC:TermGenie];"all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie];"neoxanthin anabolism" EXACT [GOC:yaf];"neoxanthin biosynthesis" EXACT [GOC:yaf];"neoxanthin formation" EXACT [GOC:yaf];"neoxanthin synthesis" EXACT [GOC:yaf] WAS "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie];"all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie];"all-trans-neoxanthin formation" EXACT [GOC:TermGenie];"all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie];"neoxanthin anabolism" EXACT [GOC:yaf];"neoxanthin biosynthesis" EXACT [GOC:yaf];"neoxanthin biosynthetic process" EXACT [GOC:yaf];"neoxanthin formation" EXACT [GOC:yaf];"neoxanthin synthesis" EXACT [GOC:yaf] biological_process GO:1901864 capsorubin metabolic process definition "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807] WAS "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] biological_process GO:1901865 capsorubin catabolic process definition "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807] WAS "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] biological_process GO:1990217 symbiont-mediated suppression of host phytoalexin production name symbiont-mediated suppression of host phytoalexin production WAS suppression by symbiont of host phytoalexin production definition "A process in which a symbiont inhibits or disrupts the production of phytoalexins in the host organism. Phytoalexins are produced by plants to fight against pathogens. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357] WAS "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357] synonyms "negative regulation by symbiont of host phytoalexin production" EXACT [];"suppression by symbiont of host phytoalexin production" EXACT [] WAS "negative regulation by symbiont of host phytoalexin production" EXACT [] cellular_component GO:0009390 dimethyl sulfoxide reductase complex definition "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [PMID:21357619, PMID:3280546] WAS "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:r0207] cellular_component GO:0062039 biofilm matrix definition "A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules." [PMID:22571672, PMID:27129222, PMID:28516088, PMID:32663461] WAS "A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells." [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088] subsets gocheck_do_not_annotate WAS N/A cellular_component GO:0098026 virus tail, tube definition "The internal tube of the tail of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [PMID:33188213, VZ:3960] WAS "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm, VZ:3960] comment Applies in particular the Myoviridae bacteriophages. Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell. WAS Applies in particular the Myoviridae bacteriophages. cellular_component GO:0180022 RQC-trigger complex definition "A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B." [PMID:12077347, PMID:28757607, PMID:32099016] WAS "A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (Human TRIP4)." [PMID:28757607, PMID:32099016] synonyms "activating signal cointegrator 1 complex" EXACT [];"ASC-1 complex" EXACT [PMID:12077347];"RQT complex" EXACT [] WAS "RQT complex" EXACT [] 77 CROSS REFERENCES CHANGES molecular_function GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity xrefs EC:6.3.4.15;MetaCyc:BIOTINLIG-RXN;RHEA:11756 WAS EC:6.3.4.15;MetaCyc:BIOTINLIG-RXN;Reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)";Reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2";Reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+";Reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+";Reactome:R-HSA-3323184 "Defective HLCS does not biotinylate ACACA:Mn2+";Reactome:R-HSA-4167511 "HLCS biotinylates ACACB";Reactome:R-HSA-9035987 "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2";Reactome:R-HSA-9035988 "Defective HLCS does not biotinylate PC:Mn2+";Reactome:R-HSA-9035990 "Defective HLCS does not biotinylate 6x(PCCA:PCCB)";RHEA:11756 molecular_function GO:0004177 aminopeptidase activity xrefs EC:3.4.11.-;https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE;MetaCyc:RXN0-5052;Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles";Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1";Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases" WAS EC:3.4.11.-;MetaCyc:RXN0-5052;Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles";Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1";Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases" molecular_function GO:0004197 cysteine-type endopeptidase activity xrefs EC:3.4.22.-;Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome";Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9";Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome";Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle";Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage";Reactome:R-HSA-139952 "Caspase-8 processing in the DISC";Reactome:R-HSA-1678920 "TLR processing at low pH";Reactome:R-HSA-1678981 "TLR9 processing at neutral pH";Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1";Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta";Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin";Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1";Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin";Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)";Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau";Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus";Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3";Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1";Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin";Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1";Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2";Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha";Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3";Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3";Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1";Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin";Reactome:R-HSA-202947 "Caspase mediated cleavage of APC";Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1";Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55";Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin";Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin";Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3";Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)";Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212";Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta";Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22";Reactome:R-HSA-2130349 "Generation of CLIP from lip10";Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10";Reactome:R-HSA-2130706 "MHC class II antigen processing";Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex";Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A";Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1";Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC";Reactome:R-HSA-350158 "LGMN degrades GC";Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)";Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)";Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK";Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk";Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2";Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin";Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2";Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31";Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3";Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1";Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin";Reactome:R-HSA-352268 "Cleavage of Satb1";Reactome:R-HSA-418845 "Activation of caspase-3";Reactome:R-HSA-418846 "Caspase cleavage of UNC5A";Reactome:R-HSA-418852 "Caspase cleavage of UNC5B";Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1";Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8";Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases";Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor";Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4";Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4";Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin";Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37";Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex";Reactome:R-HSA-933532 "Processing of caspases";Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3";Reactome:R-HSA-9647632 "CASP3 cleaves GSDME";Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD";Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins";Reactome:R-HSA-9684273 "3CLp cleaves pp1a";Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11";Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4";Reactome:R-HSA-9684336 "nsp1-4 cleaves itself";Reactome:R-HSA-9684340 "3CLp cleaves pp1ab";Reactome:R-HSA-9684351 "pp1a cleaves itself";Reactome:R-HSA-9684352 "nsp3-4 cleaves itself";Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD";Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8";Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8";Reactome:R-HSA-9694338 "nsp1-4 cleaves itself";Reactome:R-HSA-9694377 "pp1a cleaves itself";Reactome:R-HSA-9694441 "3CLp cleaves pp1a";Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11";Reactome:R-HSA-9694601 "nsp3-4 cleaves itself";Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4";Reactome:R-HSA-9694732 "3CLp cleaves pp1ab";Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)";Reactome:R-HSA-9710101 "CASP4, CASP5 cleave GSDMD";Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1";Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3";Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12" WAS EC:3.4.22.-;Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome";Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9";Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome";Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle";Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage";Reactome:R-HSA-139952 "Caspase-8 processing in the DISC";Reactome:R-HSA-1678920 "TLR processing at low pH";Reactome:R-HSA-1678981 "TLR9 processing at neutral pH";Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1";Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta";Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin";Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1";Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin";Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)";Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau";Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus";Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3";Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1";Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin";Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1";Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2";Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha";Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3";Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3";Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1";Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin";Reactome:R-HSA-202947 "Caspase mediated cleavage of APC";Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1";Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55";Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin";Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin";Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3";Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)";Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212";Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta";Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22";Reactome:R-HSA-2130349 "Generation of CLIP from lip10";Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10";Reactome:R-HSA-2130706 "MHC class II antigen processing";Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex";Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A";Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1";Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC";Reactome:R-HSA-350158 "LGMN degrades GC";Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)";Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)";Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK";Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk";Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2";Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin";Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2";Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31";Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3";Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1";Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin";Reactome:R-HSA-352268 "Cleavage of Satb1";Reactome:R-HSA-418845 "Activation of caspase-3";Reactome:R-HSA-418846 "Caspase cleavage of UNC5A";Reactome:R-HSA-418852 "Caspase cleavage of UNC5B";Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1";Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8";Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases";Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor";Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4";Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4";Reactome:R-HSA-6800797 "The PIDDosome activates CASP2";Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin";Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37";Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex";Reactome:R-HSA-933532 "Processing of caspases";Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3";Reactome:R-HSA-9647632 "CASP3 cleaves GSDME";Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD";Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins";Reactome:R-HSA-9684273 "3CLp cleaves pp1a";Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11";Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4";Reactome:R-HSA-9684336 "nsp1-4 cleaves itself";Reactome:R-HSA-9684340 "3CLp cleaves pp1ab";Reactome:R-HSA-9684351 "pp1a cleaves itself";Reactome:R-HSA-9684352 "nsp3-4 cleaves itself";Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD";Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8";Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8";Reactome:R-HSA-9694338 "nsp1-4 cleaves itself";Reactome:R-HSA-9694377 "pp1a cleaves itself";Reactome:R-HSA-9694441 "3CLp cleaves pp1a";Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11";Reactome:R-HSA-9694601 "nsp3-4 cleaves itself";Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4";Reactome:R-HSA-9694732 "3CLp cleaves pp1ab";Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)";Reactome:R-HSA-9710101 "CASP4, CASP5 cleave GSDMD";Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1";Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3";Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12" molecular_function GO:0004619 phosphoglycerate mutase activity xrefs KEGG_REACTION:R01516;Reactome:R-HSA-71445 "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG";Reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate";RHEA:15901 WAS Reactome:R-HSA-71445 "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG";Reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate";RHEA:15901 molecular_function GO:0004674 protein serine/threonine kinase activity xrefs EC:2.7.11.-;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes";Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes";Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202111 "AKT1 phosphorylates eNOS";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1";Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2";Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357";Reactome:R-HSA-9824582 "MAPK1 phosphorylates SOX10";Reactome:R-HSA-9824897 "p-S-TBK1 phosphorylates OPTN";Reactome:R-HSA-9824977 "MAPK1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824994 "RPS6KA1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824995 "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405";Reactome:R-HSA-9824999 "GSK3B phosphorylates p-S73 MITF-M at residue S69";Reactome:R-HSA-9825704 "AKT3 phosphorylates TBX3";Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P";Reactome:R-HSA-9831712 "M dimer is phosphorylated";Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated";Reactome:R-HSA-9834076 "PINK1 is autophosphorylated";Reactome:R-HSA-9834945 "PINK1 phosphorylates Ub on MOM proteins";Reactome:R-HSA-9835011 "PINK1 phosphorylates PRKN at S65";Reactome:R-HSA-9839363 "TGFBR3 phosphorylation by TGFBR2 complex";Reactome:R-HSA-9851972 "PLK1 phosphorylates FIRRM at S43";Reactome:R-HSA-9853369 "PLK1 phosphorylates FIRMM at S744";Reactome:R-HSA-9855910 "USF1 is phosphorylated by p-MAPK14";Reactome:R-HSA-9860292 "Activated IKBKB phosphorylates IRF5";Reactome:R-HSA-9860785 "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816";Reactome:R-HSA-9860800 "mTORC2 phosphorylates AKT1 on serine-473";Reactome:R-HSA-9861642 "NEK1 phosphorylates ME1" WAS EC:2.7.11.1;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes";Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes";Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202111 "AKT1 phosphorylates eNOS";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1";Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2";Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357";Reactome:R-HSA-9824582 "MAPK1 phosphorylates SOX10";Reactome:R-HSA-9824897 "p-S-TBK1 phosphorylates OPTN";Reactome:R-HSA-9824977 "MAPK1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824994 "RPS6KA1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824995 "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405";Reactome:R-HSA-9824999 "GSK3B phosphorylates p-S73 MITF-M at residue S69";Reactome:R-HSA-9825704 "AKT3 phosphorylates TBX3";Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P";Reactome:R-HSA-9831712 "M dimer is phosphorylated";Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated";Reactome:R-HSA-9834076 "PINK1 is autophosphorylated";Reactome:R-HSA-9834945 "PINK1 phosphorylates Ub on MOM proteins";Reactome:R-HSA-9835011 "PINK1 phosphorylates PRKN at S65";Reactome:R-HSA-9839363 "TGFBR3 phosphorylation by TGFBR2 complex";Reactome:R-HSA-9851972 "PLK1 phosphorylates FIRRM at S43";Reactome:R-HSA-9853369 "PLK1 phosphorylates FIRMM at S744";Reactome:R-HSA-9855910 "USF1 is phosphorylated by p-MAPK14";Reactome:R-HSA-9860292 "Activated IKBKB phosphorylates IRF5";Reactome:R-HSA-9860785 "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816";Reactome:R-HSA-9860800 "mTORC2 phosphorylates AKT1 on serine-473";Reactome:R-HSA-9861642 "NEK1 phosphorylates ME1" molecular_function GO:0008396 oxysterol 7-alpha-hydroxylase activity xrefs Reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated";Reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL";Reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL";Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL";RHEA:68740 WAS Reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated";Reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL";Reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL";Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL" molecular_function GO:0008412 4-hydroxybenzoate polyprenyltransferase activity xrefs EC:2.5.1.39;MetaCyc:RXN-11368;RHEA:44504 WAS EC:2.5.1.39;MetaCyc:RXN-11368;Reactome:R-HSA-2162192 "COQ2 ligates all-E-10PrP2 to PHB";RHEA:44504 molecular_function GO:0008695 3-phenylpropionate dioxygenase activity xrefs EC:1.14.12.19;MetaCyc:HCAMULTI-RXN;RHEA:20357;UM-BBD_enzymeID:e0307 WAS EC:1.14.12.19;MetaCyc:HCAMULTI-RXN;RHEA:20357;UM-BBD_enzymeID:r0434 molecular_function GO:0008942 nitrite reductase [NAD(P)H] activity xrefs EC:1.7.1.4;KEGG_REACTION:R00787;KEGG_REACTION:R00789;MetaCyc:RXN0-6377 WAS EC:1.7.1.4;KEGG_REACTION:R00787;KEGG_REACTION:R00789;MetaCyc:RXN0-6377;RHEA:24632 molecular_function GO:0016303 1-phosphatidylinositol-3-kinase activity xrefs EC:2.7.1.137;KEGG_REACTION:R03362;MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN;Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3";Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K";Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane";Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane";Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane";Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3";Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns";Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P";Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3";Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2";RHEA:12709 WAS EC:2.7.1.137;KEGG_REACTION:R03362;MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN;Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3";Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K";Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane";Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane";Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane";Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3";Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns";Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P";Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3";Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2";RHEA:12709;Wikipedia:Phosphoinositide_3-kinase molecular_function GO:0017040 N-acylsphingosine amidohydrolase activity xrefs EC:3.5.1.23;MetaCyc:CERAMIDASE-RXN;Reactome:R-HSA-1606583 "ASAH2 hydrolyzes ceramide (plasma membrane)";Reactome:R-HSA-1606602 "ASAH1 hydrolyzes ceramide";Reactome:R-HSA-428205 "ACER2 hydrolyzes ceramide (Golgi)";Reactome:R-HSA-428231 "ACER1 hydrolyzes ceramide (endoplasmic reticulum)";RHEA:20856 WAS EC:3.5.1.23;MetaCyc:CERAMIDASE-RXN;Reactome:R-HSA-1606583 "ASAH2 hydrolyzes ceramide (plasma membrane)";Reactome:R-HSA-1606602 "ASAH1 hydrolyzes ceramide";Reactome:R-HSA-428205 "ACER2 hydrolyzes ceramide (Golgi)";Reactome:R-HSA-428231 "ACER1 hydrolyzes ceramide (endoplasmic reticulum)";Reactome:R-HSA-428262 "ACER3 hydrolyzes phytoceramide";RHEA:20856 molecular_function GO:0018591 methyl tertiary butyl ether 3-monooxygenase activity xrefs UM-BBD_reactionID:r1023 WAS N/A molecular_function GO:0018594 tert-butanol 2-monooxygenase activity xrefs UM-BBD_reactionID:r0615 WAS N/A molecular_function GO:0018755 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity xrefs UM-BBD_reactionID:r1414 WAS N/A molecular_function GO:0018812 3-hydroxyacyl-CoA dehydratase activity xrefs EC:4.2.1.74;Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA";Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA";Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA";RHEA:33767 WAS EC:4.2.1.74;MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN;Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA";Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA";Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA";RHEA:33767 molecular_function GO:0019833 ice nucleation activity xrefs TC:9.B.133.1.1 WAS N/A molecular_function GO:0035241 protein-arginine omega-N monomethyltransferase activity xrefs EC:2.1.1.321;RHEA:48100 WAS EC:2.1.1.321;MetaCyc:2.1.1.124-RXN;RHEA:48100 molecular_function GO:0035244 protein-arginine C-methyltransferase activity xrefs EC:2.1.1.379;RHEA:66028 WAS EC:2.1.1.379;RESID:AA0272;RHEA:66028 molecular_function GO:0043786 cinnamate reductase activity xrefs RHEA:50944 WAS N/A molecular_function GO:0047403 lacto-N-biosidase activity xrefs EC:3.2.1.140;MetaCyc:RXN-8731;RHEA:21568 WAS EC:3.2.1.140;RHEA:21568 molecular_function GO:0047792 cyanohydrin beta-glucosyltransferase activity xrefs EC:2.4.1.85;MetaCyc:RXN-743;RHEA:12853 WAS EC:2.4.1.85;RHEA:12853 molecular_function GO:0051996 squalene synthase [NAD(P)H] activity xrefs EC:2.5.1.21;MetaCyc:RXN66-281 WAS EC:2.5.1.21;MetaCyc:RXN66-281;Reactome:R-HSA-191402 "Reduction of presqualene diphosphate to form squalene";Reactome:R-HSA-191405 "Two FPP molecules dimerize to form presqualene diphosphate" molecular_function GO:0052849 curcumin reductase (NADP+) activity xrefs MetaCyc:RXN0-6676;RHEA:34815 WAS EC:1.3.1.n3;MetaCyc:RXN0-6676 molecular_function GO:0052856 NAD(P)HX epimerase activity xrefs EC:5.1.99.6 WAS EC:5.1.99.6;Reactome:R-HSA-6806966 "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX" molecular_function GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity xrefs EC:1.5.3.13;KEGG_REACTION:R03899;MetaCyc:RXN-12090 WAS EC:1.5.3.13;KEGG_REACTION:R03899;MetaCyc:RXN-12090;Reactome:R-HSA-141348 "PAO:FAD oxidises NASPM to PTCN";Reactome:R-HSA-141351 "PAOX:FAD oxidises NASPN to SPM" molecular_function GO:0055056 D-glucose transmembrane transporter activity xrefs Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol";Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region";Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol";Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol";Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" WAS Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol";Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region";Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2";Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol";Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol";Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen";Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol";Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" molecular_function GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity xrefs EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9";RHEA:11508 WAS EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9";RESID:AA0026;RHEA:11508 molecular_function GO:0070330 aromatase activity xrefs EC:1.14.14.14 WAS EC:1.14.14.14;UM-BBD_reactionID:r1132;UM-BBD_reactionID:r1137 molecular_function GO:0102140 heparan sulfate N-deacetylase activity xrefs RHEA:70587 WAS MetaCyc:RXN-11557 molecular_function GO:0102274 glutathione S-conjugate carboxypeptidase activity xrefs EC:3.4.17.25;MetaCyc:RXN-12532;RHEA:60448 WAS MetaCyc:RXN-12532 molecular_function GO:0103031 L-Ala-D/L-Glu epimerase activity xrefs EC:5.1.1.20;MetaCyc:RXN0-5228;RHEA:28394 WAS MetaCyc:RXN0-5228;RHEA:28394 molecular_function GO:0106359 2-hydroxyacyl-CoA lyase activity xrefs EC:4.1.2.63 WAS EC:4.1.2.63;MetaCyc:RXN66-471 molecular_function GO:0141207 peptide lactyltransferase (ATP-dependent) activity xrefs RHEA:80271 WAS N/A molecular_function GO:0141208 NAD-dependent protein lysine delactylase activity xrefs RHEA:80287 WAS N/A molecular_function GO:0160128 pH-gated monoatomic ion channel activity xrefs Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol" WAS Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol";Wikipedia:Acid-sensing_ion_channel molecular_function GO:0160198 polyprenal reductase activity xrefs EC:1.3.1.94;MetaCyc:RXN-9971;RHEA:80727 WAS EC:1.3.1.94;MetaCyc:RXN-9971 molecular_function GO:1990055 phenylacetaldehyde synthase activity xrefs EC:4.1.1.109;MetaCyc:RXN-8990;RHEA:55532 WAS EC:4.1.1.109;RHEA:55532 biological_process GO:0006113 fermentation xrefs MetaCyc:Fermentation;Wikipedia:Fermentation_(biochemistry) WAS MetaCyc:FERMENTATION-PWY;Wikipedia:Fermentation_(biochemistry) biological_process GO:0006601 creatine biosynthetic process xrefs MetaCyc:GLYCGREAT-PWY WAS N/A biological_process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway xrefs N/A WAS MetaCyc:PWY-922 biological_process GO:0018868 2-aminobenzenesulfonate metabolic process xrefs N/A WAS UM-BBD_pathwayID:abs biological_process GO:0018873 atrazine metabolic process xrefs N/A WAS UM-BBD_pathwayID:atr biological_process GO:0018874 benzoate metabolic process xrefs UM-BBD_pathwayID:benz2 WAS MetaCyc:P321-PWY;UM-BBD_pathwayID:benz2 biological_process GO:0018875 anaerobic benzoate metabolic process xrefs UM-BBD_pathwayID:benz WAS MetaCyc:CENTBENZCOA-PWY;UM-BBD_pathwayID:benz biological_process GO:0018882 (+)-camphor metabolic process xrefs N/A WAS UM-BBD_pathwayID:cam biological_process GO:0018901 2,4-dichlorophenoxyacetic acid metabolic process xrefs N/A WAS UM-BBD_pathwayID:2\,4-d biological_process GO:0018952 parathion metabolic process xrefs N/A WAS UM-BBD_pathwayID:pthn biological_process GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway xrefs MetaCyc:PWY-922 WAS N/A biological_process GO:0019339 parathion catabolic process xrefs MetaCyc:PARATHION-DEGRADATION-PWY;UM-BBD_pathwayID:pthn WAS MetaCyc:PARATHION-DEGRADATION-PWY biological_process GO:0019381 atrazine catabolic process xrefs MetaCyc:PWY-5724;UM-BBD_pathwayID:atr WAS MetaCyc:PWY-5724 biological_process GO:0019383 (+)-camphor catabolic process xrefs MetaCyc:P601-PWY;UM-BBD_pathwayID:cam WAS MetaCyc:P601-PWY biological_process GO:0019490 2-aminobenzenesulfonate desulfonation xrefs MetaCyc:2ASDEG-PWY;UM-BBD_pathwayID:abs WAS MetaCyc:2ASDEG-PWY biological_process GO:0019664 mixed acid fermentation xrefs MetaCyc:FERMENTATION-PWY;Wikipedia:Mixed_acid_fermentation WAS Wikipedia:Mixed_acid_fermentation biological_process GO:0033387 putrescine biosynthetic process from arginine, via ornithine xrefs MetaCyc:PWY-46 WAS N/A biological_process GO:0033389 putrescine biosynthetic process from arginine, via agmatine xrefs MetaCyc:PWY-40 WAS N/A biological_process GO:0033390 putrescine biosynthetic process from arginine via N-carbamoylputrescine xrefs MetaCyc:PWY-43 WAS N/A biological_process GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity xrefs VZ:665 WAS N/A biological_process GO:0039673 symbiont-mediated suppression of host dendritic cell mediated immune response xrefs VZ:869 WAS N/A biological_process GO:0042203 toluene catabolic process xrefs UM-BBD_pathwayID:tol WAS N/A biological_process GO:0046300 2,4-dichlorophenoxyacetic acid catabolic process xrefs UM-BBD_pathwayID:2\,4-d WAS N/A biological_process GO:0052150 symbiont-mediated perturbation of host apoptosis xrefs VZ:1518 "Apoptosis modulation" WAS VZ:1518 "Apoptosis modulation";VZ:1581 "Apoptosis modulation" biological_process GO:0052165 symbiont-mediated perturbation of host phytoalexin production xrefs PMID:28805743 WAS N/A biological_process GO:0052776 chitin catabolic process to fructose 6-phosphate via glucosamine xrefs MetaCyc:PWY-6855 WAS N/A biological_process GO:0071514 genomic imprinting xrefs N/A WAS Wikipedia:Genomic_imprinting biological_process GO:0090638 phosphatidylcholine biosynthesis from phosphatidylethanolamine xrefs MetaCyc:PWY-6825 WAS N/A biological_process GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine xrefs MetaCyc:PWY-7470 WAS N/A biological_process GO:1901158 neomycin biosynthetic process xrefs MetaCyc:PWY-7016 WAS N/A biological_process GO:1901774 lincomycin biosynthetic process xrefs MetaCyc:PWY-6955 WAS N/A biological_process GO:1901780 pentalenolactone biosynthetic process xrefs MetaCyc:PWY-6915 WAS N/A biological_process GO:1901782 p-cumate catabolic process xrefs MetaCyc:PWY-5273 WAS N/A biological_process GO:1901802 1,5-anhydro-D-fructose catabolic process xrefs MetaCyc:PWY-6992 WAS N/A biological_process GO:1901812 beta-carotene biosynthetic process xrefs MetaCyc:PWY-5943 WAS N/A biological_process GO:1901815 astaxanthin biosynthetic process xrefs MetaCyc:PWY-5288 WAS N/A biological_process GO:1901824 alpha-carotene biosynthetic process xrefs MetaCyc:PWY-5946 WAS N/A biological_process GO:1901827 zeaxanthin biosynthetic process xrefs MetaCyc:PWY-5944 WAS N/A biological_process GO:1901830 zeaxanthin bis(beta-D-glucoside) biosynthetic process xrefs MetaCyc:PWY-6288 WAS N/A biological_process GO:1901833 neoxanthin biosynthetic process xrefs MetaCyc:PWY-6809 WAS N/A 141 RELATION CHANGES molecular_function GO:0000010 heptaprenyl diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity is_a GO:0033764 WAS GO:0016616 molecular_function GO:0003707 nuclear steroid receptor activity relationship part_of GO:0030518 WAS part_of GO:0043401 molecular_function GO:0004161 dimethylallyltranstransferase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0004230 glutamyl aminopeptidase activity is_a GO:0004177 WAS N/A molecular_function GO:0004311 geranylgeranyl diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0004508 steroid 17-alpha-monooxygenase activity is_a GO:0008395;GO:0016712 WAS GO:0008395;GO:0016705 molecular_function GO:0004509 steroid 21-monooxygenase activity is_a GO:0008395;GO:0016712 WAS GO:0008395;GO:0016705 molecular_function GO:0004883 nuclear glucocorticoid receptor activity is_a GO:0003707 WAS GO:0004879 molecular_function GO:0008123 cholesterol 7-alpha-monooxygenase activity is_a GO:0008387;GO:0016712 WAS GO:0008387;GO:0016709 molecular_function GO:0008390 testosterone 16-alpha-hydroxylase activity is_a GO:0008395;GO:0016712 WAS GO:0008395;GO:0016705 molecular_function GO:0008834 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0016172 antifreeze activity is_a GO:0050825 WAS N/A molecular_function GO:0016285 alanyl aminopeptidase activity is_a GO:0004177 WAS N/A molecular_function GO:0019833 ice nucleation activity is_a GO:0050825 WAS N/A molecular_function GO:0030284 nuclear estrogen receptor activity is_a GO:0003707 WAS GO:0004879 molecular_function GO:0031073 cholesterol 26-hydroxylase activity is_a GO:0008395;GO:0016716 WAS GO:0008395 molecular_function GO:0033782 24S-hydroxycholesterol 7alpha-hydroxylase activity is_a GO:0008387;GO:0016712 WAS GO:0008396;GO:0016712 molecular_function GO:0033783 25-hydroxycholesterol 7alpha-hydroxylase activity is_a GO:0008387;GO:0016712 WAS GO:0008396;GO:0016712 molecular_function GO:0036423 hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0044687 geranylfarnesyl diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity is_a GO:0030283 WAS GO:0033764 molecular_function GO:0047863 dimethylallylcistransferase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0050212 progesterone 11-alpha-monooxygenase activity is_a GO:0008395;GO:0016705 WAS GO:0004497;GO:0016705 molecular_function GO:0050214 progesterone monooxygenase activity is_a GO:0008395;GO:0016705 WAS GO:0004497;GO:0016705 molecular_function GO:0050267 rubber cis-polyprenylcistransferase activity is_a GO:0120531 WAS GO:0002094 molecular_function GO:0050292 steroid 9-alpha-monooxygenase activity is_a GO:0008395;GO:0016705 WAS GO:0004497;GO:0016705 molecular_function GO:0052922 hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0052923 all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0052924 all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0097269 all-trans-decaprenyl-diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0102059 (2Z,6Z)-farnesyl diphosphate synthase activity is_a GO:0120531 WAS GO:0016765 molecular_function GO:0102175 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase (NAD+) activity is_a GO:0033764 WAS GO:0016616 molecular_function GO:0102191 3-beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (NAD+) activity is_a GO:0102175 WAS GO:0016616 molecular_function GO:0106350 all-trans-octaprenyl-diphosphate synthase activity is_a GO:0120531 WAS GO:0004659 molecular_function GO:0160191 steroid 22S-hydroxylase activity is_a GO:0008395;GO:0016712 WAS GO:0016712 biological_process GO:0002323 natural killer cell activation involved in immune response relationship part_of GO:0045087 WAS N/A intersection_of is_a GO:0030101;part_of GO:0045087 WAS is_a GO:0030101;part_of GO:0006955 biological_process GO:0002324 natural killer cell proliferation involved in immune response is_a GO:0001787;GO:0002285 WAS GO:0001787;GO:0002323 biological_process GO:0002325 natural killer cell differentiation involved in immune response is_a GO:0001779;GO:0002285 WAS GO:0001779;GO:0002323 biological_process GO:0009051 pentose-phosphate shunt, oxidative branch is_a GO:0006740;GO:1901135 WAS GO:0006740;GO:0051156 relationship has_part GO:0004345;has_part GO:0004616;has_part GO:0017057;part_of GO:0006098 WAS has_part GO:0004341;has_part GO:0004345;has_part GO:0004616;part_of GO:0006098 biological_process GO:0009271 phage shock is_a GO:0006950 WAS GO:0006950;GO:0098586 biological_process GO:0010115 regulation of abscisic acid biosynthetic process is_a GO:0019747;GO:0046890;GO:1902930 WAS GO:0010565;GO:0019747;GO:0043455;GO:0046890;GO:1902930 biological_process GO:0019057 symbiont-mediated perturbation of host translation is_a GO:0039656 WAS GO:0044068 biological_process GO:0019065 receptor-mediated endocytosis of virus by host cell relationship part_of GO:0046718 WAS N/A biological_process GO:0019087 symbiont-mediated transformation of host cell is_a GO:0044068 WAS GO:0019054 biological_process GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway is_a GO:0007034;GO:0032509;GO:0045324 WAS GO:0032509;GO:0045324 biological_process GO:0032981 mitochondrial respiratory chain complex I assembly is_a GO:0010257;GO:0033108 WAS GO:0010257;GO:0033108;GO:0097250 biological_process GO:0033108 mitochondrial respiratory chain complex assembly relationship occurs_in GO:0005739;part_of GO:0007005 WAS part_of GO:0007005 biological_process GO:0033387 putrescine biosynthetic process from arginine, via ornithine is_a GO:0033388 WAS GO:0006591;GO:0009446 biological_process GO:0033388 putrescine biosynthetic process from arginine is_a GO:0006525;GO:0009064;GO:0009446 WAS GO:0006525;GO:0009446 biological_process GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly is_a GO:0033108;GO:0043461 WAS GO:0043461;GO:0097250 relationship N/A WAS part_of GO:0007005 biological_process GO:0033617 mitochondrial cytochrome c oxidase assembly is_a GO:0008535;GO:0033108 WAS GO:0008535;GO:0033108;GO:0097250 biological_process GO:0033668 symbiont-mediated suppression of host apoptosis is_a GO:0052041;GO:0052150 WAS GO:0052041 biological_process GO:0034055 effector-mediated activation of host programmed cell death by symbiont is_a GO:0052042;GO:0140403 WAS GO:0034053;GO:0052042;GO:0052170;GO:0140418 biological_process GO:0034551 mitochondrial respiratory chain complex III assembly is_a GO:0017062;GO:0033108 WAS GO:0017062;GO:0033108;GO:0097250 biological_process GO:0034553 mitochondrial respiratory chain complex II assembly is_a GO:0033108;GO:0034552 WAS GO:0033108;GO:0034552;GO:0097250 biological_process GO:0036522 symbiont-mediated suppression of host protein localization to phagocytic vesicle is_a GO:0044068 WAS GO:0044003 biological_process GO:0039520 symbiont-mediated activation of host autophagy is_a GO:0075071 WAS GO:0010508;GO:0039519;GO:0044068 intersection_of N/A WAS is_a GO:0044068;positively_regulates GO:0006914 biological_process GO:0039522 symbiont-mediated suppression of host mRNA export from nucleus is_a GO:0039657;GO:0052038 WAS GO:0044003 biological_process GO:0039524 symbiont-mediated suppression of host mRNA processing is_a GO:0039656 WAS GO:0044003 biological_process GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity is_a GO:0052031 WAS GO:0019049 biological_process GO:0039592 symbiont-mediated arrest of host cell cycle during G2/M transition is_a GO:0044071 WAS GO:0044003 biological_process GO:0039595 symbiont-mediated degradation of host mRNA is_a GO:0039656 WAS GO:0044068 biological_process GO:0039602 symbiont-mediated suppression of host transcription initiation from RNA polymerase II promoter is_a GO:0039656 WAS GO:0044003 biological_process GO:0039604 symbiont-mediated suppression of host translation is_a GO:0019057 WAS GO:0044003 biological_process GO:0039606 symbiont-mediated suppression of host translation initiation is_a GO:0039656 WAS GO:0044003 biological_process GO:0039635 symbiont-mediated suppression of host peptidoglycan biosynthetic process is_a GO:0044068 WAS GO:0039636 biological_process GO:0039636 symbiont-mediated suppression of host cell wall biogenesis is_a GO:0044068 WAS GO:0019054 biological_process GO:0039639 suppression by virus of host cell lysis in response to superinfection is_a GO:0016032 WAS GO:0098586 biological_process GO:0039653 symbiont-mediated suppression of host transcription is_a GO:0052026 WAS GO:0044003 biological_process GO:0039657 symbiont-mediated suppression of host gene expression is_a GO:0039656 WAS GO:0044003 biological_process GO:0039671 symbiont-mediated perturbation of host natural killer cell mediated immune response is_a GO:0044068;GO:0052167 WAS GO:0019049 biological_process GO:0039673 symbiont-mediated suppression of host dendritic cell mediated immune response is_a GO:0052167 WAS GO:0019049 biological_process GO:0039674 exit of virus from host cell nucleus is_a GO:0016032;GO:0035891 WAS GO:0035891 biological_process GO:0044509 envenomation resulting in modulation of signal transduction in another organism relationship N/A WAS has_part GO:0044501 biological_process GO:0044542 symbiont-mediated activation of host plasminogen is_a GO:0044068 WAS GO:0044003 biological_process GO:0044759 symbiont-mediated suppression of host synaptic transmission is_a GO:0044758 WAS GO:0044758;GO:0050805 biological_process GO:0044761 symbiont-mediated suppression of host cholinergic synaptic transmission is_a GO:0044759;GO:0044760 WAS GO:0044003 biological_process GO:0044865 symbiont-mediated suppression of host cell division is_a GO:0044068 WAS GO:0044863;GO:0051782 biological_process GO:0045324 late endosome to vacuole transport is_a GO:0016192 WAS GO:0007034;GO:0016192 biological_process GO:0046597 blocking of symbiont entry into host cell is_a GO:0035821;GO:0045087;GO:0051851 WAS GO:0046596;GO:1903901 relationship N/A WAS negatively_regulates GO:0046718 intersection_of N/A WAS is_a GO:0065007;negatively_regulates GO:0046718 biological_process GO:0046773 symbiont-mediated suppression of host translation termination is_a GO:0039656 WAS GO:0044003 biological_process GO:0046780 symbiont-mediated suppression of host mRNA splicing is_a GO:0039524 WAS GO:0033119;GO:0039524 biological_process GO:0046784 viral mRNA export from host cell nucleus is_a GO:0016032 WAS GO:0044417 relationship part_of GO:0019080 WAS N/A biological_process GO:0051607 defense response to virus is_a GO:0009615;GO:0098542 WAS GO:0009615;GO:0140546 biological_process GO:0052003 symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway is_a GO:0052081 WAS GO:0009968;GO:0010113;GO:0044414;GO:0052081;GO:0052089 relationship negatively_regulates GO:0009627;negatively_regulates GO:0009862 WAS negatively_regulates GO:0009862 biological_process GO:0052026 symbiont-mediated perturbation of host transcription is_a GO:0039656 WAS GO:0044068 biological_process GO:0052032 symbiont-mediated perturbation of host inflammatory response is_a GO:0052167 WAS GO:0052031 biological_process GO:0052036 symbiont-mediated suppression of host inflammatory response is_a GO:0052032 WAS GO:0044414;GO:0052032 biological_process GO:0052041 symbiont-mediated suppression of host programmed cell death is_a GO:0052040 WAS GO:0044003 biological_process GO:0052042 symbiont-mediated activation of host programmed cell death is_a GO:0052040 WAS GO:0044003 relationship N/A WAS part_of GO:0001907 biological_process GO:0052081 symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway is_a GO:0052027 WAS GO:0052027;GO:0052031 biological_process GO:0052088 symbiont-mediated perturbation of host jasmonic acid signaling is_a GO:0052027;GO:0052167 WAS GO:0042783 biological_process GO:0052091 modulation of nutrient release by host is_a GO:0044002 WAS GO:0044003 relationship N/A WAS part_of GO:0044002 biological_process GO:0052158 symbiont-mediated perturbation of host resistance gene-dependent defense response is_a GO:0030682;GO:0052167 WAS GO:0075136 biological_process GO:0052160 symbiont-mediated perturbation of host systemic acquired resistance is_a GO:0052031 WAS GO:0044003 biological_process GO:0052167 symbiont-mediated perturbation of host innate immune response is_a GO:0052553 WAS GO:0052031;GO:0052553 biological_process GO:0052170 symbiont-mediated suppression of host innate immune response is_a GO:0052167;GO:0052562 WAS GO:0044414;GO:0052167;GO:0052562 biological_process GO:0052200 symbiont-mediated response to host defenses is_a GO:0075136 WAS GO:0052173;GO:0075136 biological_process GO:0052322 positive regulation of phytoalexin biosynthetic process is_a GO:0140546;GO:1900378 WAS GO:0052319;GO:0052320;GO:1900378 biological_process GO:0052553 symbiont-mediated perturbation of host immune response is_a GO:0052031 WAS GO:0044003 biological_process GO:0052562 symbiont-mediated suppression of host immune response is_a GO:0052553 WAS GO:0044003 biological_process GO:0052776 chitin catabolic process to fructose 6-phosphate via glucosamine is_a GO:0006032;GO:0006083;GO:0006796;GO:0019637 WAS GO:0006041;GO:0006083;GO:0052777 biological_process GO:0060141 symbiont-mediated induction of syncytium formation is_a GO:0044068 WAS GO:0044003 biological_process GO:0075509 endocytosis involved in viral entry into host cell is_a GO:0046718 WAS GO:0006897;GO:0046794 relationship N/A WAS part_of GO:0046718 intersection_of N/A WAS is_a GO:0006897;part_of GO:0046718 biological_process GO:0075733 intracellular transport of virus is_a GO:0044403;GO:0046794 WAS GO:0046794 biological_process GO:0080185 effector-mediated activation of plant hypersensitive response by symbiont is_a GO:0034055;GO:0052158 WAS GO:0052042;GO:0052158;GO:0140404 biological_process GO:0090120 lysosome to ER cholesterol transport is_a GO:0007041;GO:0016192;GO:0032367 WAS GO:0007041;GO:0090119 biological_process GO:0090727 positive regulation of brood size is_a GO:0065007 WAS GO:0060378 biological_process GO:0090728 negative regulation of brood size is_a GO:0065007 WAS GO:0060378 biological_process GO:0097250 mitochondrial respirasome assembly is_a GO:0007005;GO:0033108 WAS GO:0007005;GO:0065003 relationship N/A WAS occurs_in GO:0005739 biological_process GO:0098673 symbiont-mediated suppression of host DNA replication is_a GO:0044068 WAS GO:0044003 biological_process GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome is_a GO:0016192;GO:0097120 WAS GO:0016192;GO:0062237;GO:0072594;GO:0097120;GO:0099637;GO:1902946 biological_process GO:0099015 degradation of host chromosome by virus is_a GO:0016032 WAS GO:0039637 relationship part_of GO:0039693 WAS N/A biological_process GO:0140321 symbiont-mediated suppression of host autophagy is_a GO:0075071 WAS GO:0044003 biological_process GO:0140415 effector-mediated perturbation of host defenses by symbiont is_a GO:0052031;GO:0052200;GO:0140418 WAS GO:0052200;GO:0140418 biological_process GO:0140502 effector-mediated suppression of host salicylic acid-mediated innate immune signaling is_a GO:0052003;GO:0052029;GO:0140404 WAS GO:0052003;GO:0140404 biological_process GO:0140590 effector-mediated suppression of host defense response is_a GO:0140415 WAS GO:0044414;GO:0140415 biological_process GO:0140754 reorganization of cellular membranes to establish viral sites of replication is_a GO:0141171 WAS GO:0051702 biological_process GO:0140755 reorganization of host cellular membranes to establish sites of replication is_a GO:0016032;GO:0141171 WAS GO:0019054 biological_process GO:0140883 symbiont-mediated activation of host reticulophagy is_a GO:0039520 WAS GO:0044068;GO:0141088 biological_process GO:0140976 host defense response against symbiont-mediated perturbation of plasma membrane integrity is_a GO:0140546 WAS GO:0098542 biological_process GO:0141023 symbiont-mediated disruption of host cell-cell adhesion is_a GO:0044068 WAS GO:0044003 biological_process GO:0141073 symbiont-mediated perturbation of host opsonization is_a GO:0052031 WAS GO:0044003 biological_process GO:0141083 symbiont-mediated suppression of host reactive oxygen species generation is_a GO:0044068;GO:0052031 WAS GO:0044003 biological_process GO:0141145 symbiont-mediated suppression of host neutrophil extracellular trap formation is_a GO:0044068;GO:0052031 WAS GO:0044068 biological_process GO:0141154 symbiont-mediated suppression of host-directed shutoff of host translation is_a GO:0044414 WAS GO:0019057 biological_process GO:0141155 symbiont-mediated suppression of host translation elongation is_a GO:0039656 WAS GO:0044003 biological_process GO:0141157 symbiont-mediated suppression of host exocytosis is_a GO:1990215 WAS GO:0044003 biological_process GO:0141158 symbiont-mediated suppression of host phagosome maturation is_a GO:0044068 WAS GO:0044003 biological_process GO:0141159 symbiont-mediated suppression of host phagosome acidification is_a GO:0052031 WAS GO:0044003 biological_process GO:1901183 positive regulation of camalexin biosynthetic process is_a GO:0051176;GO:0052322 WAS GO:0051176;GO:0052322;GO:1901182 biological_process GO:1901252 regulation of intracellular transport of viral material is_a GO:0043903;GO:1903900 WAS GO:1903900 biological_process GO:1901824 alpha-carotene biosynthetic process is_a GO:0016117;GO:0016120 WAS GO:0016117;GO:0016120;GO:1901822 biological_process GO:1903914 negative regulation of fusion of virus membrane with host plasma membrane is_a GO:0048525;GO:0051129;GO:1903913 WAS GO:0046597;GO:0051129;GO:1903913 relationship negatively_regulates GO:0019064;negatively_regulates GO:0046718 WAS negatively_regulates GO:0019064 biological_process GO:1904187 regulation of transformation of host cell by virus is_a GO:0043903 WAS GO:0043903;GO:0050792 biological_process GO:1904188 negative regulation of transformation of host cell by virus is_a GO:0048519;GO:1904187 WAS GO:0048525;GO:1904187 biological_process GO:1904189 positive regulation of transformation of host cell by virus is_a GO:0048518;GO:1904187 WAS GO:0048524;GO:1904187 biological_process GO:1990216 symbiont-mediated activation of host transcription is_a GO:0052026 WAS GO:0044003