format-version: 1.2 data-version: go/releases/2026-07-02/subsets/goslim_chembl.owl subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3." subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_obsoletion_candidate "Terms planned for obsoletion" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_drosophila "Drosophila GO slim" subsetdef: goslim_euk_cellular_processes_ribbon "GO ribbon for eukaroytic cellular processes" subsetdef: goslim_flybase_ribbon "Insecta GO ribbon slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_plant_ribbon "Plant GO ribbon" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_prokaryote "GO subset for prokaryotes" subsetdef: goslim_prokaryote_ribbon "Prokaryote GO ribbon slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_virus "GO subset for viruses" subsetdef: goslim_yeast "Yeast GO slim" synonymtypedef: syngo_official_label "label approved by the SynGO project" synonymtypedef: systematic_synonym "Systematic synonym" EXACT ontology: go/subsets/goslim_chembl property_value: owl:versionInfo "2026-07-02" xsd:string [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] subset: goslim_chembl synonym: "SNAP receptor binding" EXACT [] xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming" xref: Reactome:R-HSA-210430 "Release of L-Glutamate at the synapse" xref: Reactome:R-HSA-265166 "Exocytosis of Insulin" xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming" xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse" xref: Reactome:R-HSA-374899 "Release of noradrenaline at the synapse" xref: Reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming" xref: Reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport" xref: Reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport" xref: Reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport" xref: Reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming" xref: Reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle" xref: Reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle" xref: Reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming" xref: Reactome:R-HSA-888589 "Release of GABA at the synapse" xref: Reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane" xref: Reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming" is_a: GO:0005515 ! protein binding [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0003674 ! molecular_function [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function alt_id: GO:0008665 def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] subset: goslim_chembl synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160] synonym: "2'-phosphotransferase activity" BROAD [] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN xref: RHEA:23324 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: exactMatch http://purl.uniprot.org/enzyme/2.7.1.160 property_value: exactMatch http://rdf.rhea-db.org/23324 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic" xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:curators, GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] subset: goslim_chembl synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: Reactome:R-HSA-2046222 "CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain" xref: Reactome:R-HSA-3656269 "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG" xref: Reactome:R-HSA-6786012 "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001540 name: amyloid-beta binding namespace: molecular_function def: "Binding to an amyloid-beta peptide/protein." [GOC:hjd] subset: goslim_chembl synonym: "beta-amyloid binding" EXACT [] is_a: GO:0042277 ! peptide binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20109" xsd:anyURI [Term] id: GO:0001618 name: virus receptor activity namespace: molecular_function def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] subset: goslim_chembl subset: goslim_generic synonym: "viral receptor activity" EXACT [] xref: Reactome:R-HSA-9922480 "Dengue virion gets internalized" is_a: GO:0005515 ! protein binding relationship: part_of GO:0044403 ! biological process involved in symbiotic interaction [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0008150 ! biological_process [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Binding to a nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" NARROW [] synonym: "microtubule/chromatin interaction" NARROW [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003700 name: DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 alt_id: GO:0001071 alt_id: GO:0001130 alt_id: GO:0001131 alt_id: GO:0001151 alt_id: GO:0001199 alt_id: GO:0001204 def: "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial-type DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW [] synonym: "DNA binding transcription factor activity" EXACT [] synonym: "gene-specific transcription factor activity" EXACT [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "nucleic acid binding transcription factor activity" BROAD [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] synonym: "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW [] synonym: "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] xref: Reactome:R-HSA-163666 "Formation of ChREBP:MLX heterodimer" is_a: GO:0003674 ! molecular_function relationship: has_part GO:0003677 ! DNA binding relationship: part_of GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/15704" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/16534" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20253" xsd:anyURI created_by: krc creation_date: 2010-10-21T04:37:54Z [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0000498 alt_id: GO:0044822 def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function alt_id: GO:0000499 def: "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] subset: goslim_chembl subset: goslim_yeast synonym: "base pairing with mRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005840 ! ribosome relationship: occurs_in GO:0005622 ! intracellular anatomical structure relationship: occurs_in GO:0005840 ! ribosome [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell." [GOC:jl, ISBN:0198506732, ISBN:0721662544] subset: goslim_chembl subset: goslim_pir synonym: "antibody activity" RELATED [] synonym: "B cell receptor activity" NARROW [] synonym: "major histocompatibility complex activity" NARROW [] synonym: "major histocompatibility complex antigen display activity" NARROW [] synonym: "MHC activity" NARROW [] synonym: "opsonin activity" NARROW [] is_a: GO:0003674 ! molecular_function property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25644" xsd:anyURI [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+." [RHEA:17777] subset: goslim_chembl synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" RELATED [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN xref: Reactome:R-HSA-8869206 "PAFAH2 hydrolyses PAF to lyso-PAF and acetate" xref: RHEA:17777 xref: RHEA:40479 xref: RHEA:41183 xref: RHEA:41368 xref: RHEA:41372 xref: RHEA:41376 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.47 property_value: exactMatch http://rdf.rhea-db.org/17777 property_value: narrowMatch http://rdf.rhea-db.org/40479 property_value: narrowMatch http://rdf.rhea-db.org/41183 property_value: narrowMatch http://rdf.rhea-db.org/41368 property_value: narrowMatch http://rdf.rhea-db.org/41372 property_value: narrowMatch http://rdf.rhea-db.org/41376 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+." [EC:2.7.6.3, RHEA:11412] subset: goslim_chembl synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" RELATED [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" RELATED [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" RELATED [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" RELATED [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" RELATED [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" RELATED [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" RELATED [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" RELATED [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG_REACTION:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11412 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: exactMatch http://purl.uniprot.org/enzyme/2.7.6.3 property_value: exactMatch http://rdf.rhea-db.org/11412 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function alt_id: GO:0061745 def: "Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "GTPase activity, coupled" RELATED [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: MetaCyc:RXN0-5462 xref: Reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP" xref: Reactome:R-HSA-1458485 "RALA hydrolyzes GTP" xref: Reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP" xref: Reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP" xref: Reactome:R-HSA-167415 "G-protein alpha subunit is inactivated" xref: Reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf" xref: Reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf" xref: Reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha" xref: Reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle" xref: Reactome:R-HSA-203973 "Vesicle budding" xref: Reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome" xref: Reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle" xref: Reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP" xref: Reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP" xref: Reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission" xref: Reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha" xref: Reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission" xref: Reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC" xref: Reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA" xref: Reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome" xref: Reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits" xref: Reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)" xref: Reactome:R-HSA-555065 "Formation of clathrin coated vesicle" xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4" xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP" xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity" xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" xref: Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP" xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase" xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity" xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP" xref: Reactome:R-HSA-8847534 "RAB43 hydrolyses GTP" xref: Reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity" xref: Reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity" xref: Reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35" xref: Reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7" xref: Reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7" xref: Reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A" xref: Reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B" xref: Reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission" xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity" xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated" xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated" xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated" xref: Reactome:R-HSA-9018814 "RHOT1 hydrolyzes GTP" xref: Reactome:R-HSA-9018826 "RHOT2 hydrolyzes GTP" xref: Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP" xref: Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP" xref: Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP" xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle" xref: Reactome:R-HSA-9947842 "GBP1 hydrolyzes GTP forming GBP1 oligomers" xref: Reactome:R-HSA-9954919 "ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released" xref: RHEA:19669 is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity property_value: exactMatch http://rdf.rhea-db.org/19669 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19078" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26014" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI created_by: dph creation_date: 2015-11-11T12:47:56Z [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: goslim_chembl synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" RELATED [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" RELATED [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" RELATED [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" RELATED [EC:3.1.1.7] synonym: "choline esterase I activity" RELATED [EC:3.1.1.7] synonym: "true cholinesterase activity" RELATED [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN xref: Reactome:R-HSA-372519 "AcCho is hydrolyzed to Cho and acetate by ACHE" xref: RHEA:17561 is_a: GO:0004104 ! cholinesterase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.7 property_value: exactMatch http://rdf.rhea-db.org/17561 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [RHEA:21708] subset: goslim_chembl synonym: "adenosylhomocysteine hydrolase activity" RELATED [] synonym: "AdoHcyase activity" RELATED [] synonym: "S-adenosyl-L-homocysteine hydrolase activity" RELATED [] synonym: "S-adenosylhomocysteinase activity" RELATED [] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [] synonym: "S-adenosylhomocysteine synthase activity" RELATED [] synonym: "SAHase activity" RELATED [] xref: EC:3.13.2.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:R-HSA-174401 "AHCY:NAD+ tetramer hydrolyses AdoHcy" xref: Reactome:R-HSA-5579084 "Defective AHCY does not hydrolyse AdoHcy" xref: RHEA:21708 is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.13.2.1 property_value: exactMatch http://rdf.rhea-db.org/21708 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24053" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" RELATED [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" RELATED [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" RELATED [EC:2.8.2.2] synonym: "sterol sulfokinase activity" RELATED [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" RELATED [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL" xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP" xref: RHEA:22552 xref: RHEA:59300 xref: RHEA:59304 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.2 property_value: exactMatch http://rdf.rhea-db.org/22552 property_value: narrowMatch http://rdf.rhea-db.org/59300 property_value: narrowMatch http://rdf.rhea-db.org/59304 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: goslim_chembl synonym: "1-naphthol phenol sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" RELATED [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "phenol sulfokinase activity" RELATED [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" RELATED [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-158468 "SULT1A1 dimer sulfonates PARA to PARA-SO4" xref: Reactome:R-HSA-158849 "Phenol can form a sulfate conjugate" xref: Reactome:R-HSA-158860 "SULT1A1 dimer sulfonates NHABP" xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS" xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP" xref: RHEA:12164 xref: RHEA:66548 xref: RHEA:66572 xref: RHEA:66576 xref: RHEA:66580 xref: RHEA:67876 xref: RHEA:67888 xref: RHEA:67892 xref: RHEA:83343 xref: RHEA:83351 xref: RHEA:83575 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.1 property_value: exactMatch http://rdf.rhea-db.org/12164 property_value: narrowMatch http://rdf.rhea-db.org/66548 property_value: narrowMatch http://rdf.rhea-db.org/66572 property_value: narrowMatch http://rdf.rhea-db.org/66576 property_value: narrowMatch http://rdf.rhea-db.org/66580 property_value: narrowMatch http://rdf.rhea-db.org/67876 property_value: narrowMatch http://rdf.rhea-db.org/67888 property_value: narrowMatch http://rdf.rhea-db.org/67892 property_value: narrowMatch http://rdf.rhea-db.org/83343 property_value: narrowMatch http://rdf.rhea-db.org/83351 property_value: narrowMatch http://rdf.rhea-db.org/83575 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: goslim_chembl synonym: "acylcholine acylhydrolase activity" RELATED [EC:3.1.1.8] synonym: "anticholineesterase activity" RELATED [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" RELATED [EC:3.1.1.8] synonym: "BtChoEase activity" RELATED [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" RELATED [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" RELATED [EC:3.1.1.8] synonym: "choline esterase activity" RELATED [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" RELATED [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" RELATED [EC:3.1.1.8] synonym: "propionylcholinesterase activity" RELATED [EC:3.1.1.8] synonym: "pseudocholinesterase activity" RELATED [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: RHEA:21964 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.8 property_value: exactMatch http://rdf.rhea-db.org/21964 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate." [RHEA:10248] subset: goslim_chembl synonym: "deoxyuridine-triphosphatase activity" RELATED [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" RELATED [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" RELATED [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" RELATED [EC:3.6.1.23] xref: EC:3.6.1.23 xref: KEGG_REACTION:R02100 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate" xref: RHEA:10248 is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.6.1.23 property_value: exactMatch http://rdf.rhea-db.org/10248 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] subset: goslim_chembl synonym: "blood coagulation factor activity" RELATED [] synonym: "serine elastase activity" RELATED [GOC:krc] xref: EC:3.4.21.- xref: EC:3.4.21.1 xref: EC:3.4.21.10 xref: EC:3.4.21.102 xref: EC:3.4.21.20 xref: EC:3.4.21.21 xref: EC:3.4.21.22 xref: EC:3.4.21.26 xref: EC:3.4.21.27 xref: EC:3.4.21.34 xref: EC:3.4.21.35 xref: EC:3.4.21.36 xref: EC:3.4.21.38 xref: EC:3.4.21.39 xref: EC:3.4.21.4 xref: EC:3.4.21.41 xref: EC:3.4.21.42 xref: EC:3.4.21.43 xref: EC:3.4.21.45 xref: EC:3.4.21.46 xref: EC:3.4.21.47 xref: EC:3.4.21.48 xref: EC:3.4.21.5 xref: EC:3.4.21.53 xref: EC:3.4.21.54 xref: EC:3.4.21.59 xref: EC:3.4.21.6 xref: EC:3.4.21.61 xref: EC:3.4.21.62 xref: EC:3.4.21.68 xref: EC:3.4.21.69 xref: EC:3.4.21.7 xref: EC:3.4.21.71 xref: EC:3.4.21.73 xref: EC:3.4.21.75 xref: EC:3.4.21.78 xref: EC:3.4.21.79 xref: EC:3.4.21.83 xref: EC:3.4.21.88 xref: EC:3.4.21.9 xref: EC:3.4.21.92 xref: EC:3.4.21.93 xref: EC:3.4.21.94 xref: Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them" xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein" xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage" xref: Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides" xref: Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)" xref: Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide (thrombin catalyst)" xref: Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)" xref: Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)" xref: Reactome:R-HSA-140769 "factor VII -> factor VIIa" xref: Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)" xref: Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)" xref: Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B" xref: Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin" xref: Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form" xref: Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C" xref: Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin" xref: Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2" xref: Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases" xref: Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases" xref: Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS" xref: Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer" xref: Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)" xref: Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)" xref: Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin" xref: Reactome:R-HSA-158313 "factor XII -> factor XIIa" xref: Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)" xref: Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)" xref: Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin" xref: Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)" xref: Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin" xref: Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)" xref: Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)" xref: Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR" xref: Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)" xref: Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE" xref: Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2" xref: Reactome:R-HSA-1592297 "Full activation of MMP1" xref: Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)" xref: Reactome:R-HSA-1592316 "Initial activation of proMMP1" xref: Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3" xref: Reactome:R-HSA-1592371 "Initial activation of proMMP3" xref: Reactome:R-HSA-1592398 "Activation of proMMP8" xref: Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs" xref: Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin" xref: Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X" xref: Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C" xref: Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S" xref: Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX" xref: Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII" xref: Reactome:R-HSA-1602458 "Activation of proMMP10" xref: Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN" xref: Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1" xref: Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN" xref: Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin" xref: Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7" xref: Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14" xref: Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2" xref: Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs" xref: Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin" xref: Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases" xref: Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3" xref: Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13" xref: Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)" xref: Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3" xref: Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7" xref: Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z" xref: Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6" xref: Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2" xref: Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b" xref: Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b" xref: Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases" xref: Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN" xref: Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein" xref: Reactome:R-HSA-173626 "Activation of C1r" xref: Reactome:R-HSA-173631 "Activation of C1s" xref: Reactome:R-HSA-173680 "Activation of C5" xref: Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B" xref: Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase" xref: Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein" xref: Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B" xref: Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a" xref: Reactome:R-HSA-186785 "PDGF-AA clevage by Furin" xref: Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF" xref: Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH" xref: Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN" xref: Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))" xref: Reactome:R-HSA-2129357 "Fibrillin C-terminal processing" xref: Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release" xref: Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding" xref: Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding" xref: Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1" xref: Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins" xref: Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding" xref: Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE" xref: Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2" xref: Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE" xref: Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS" xref: Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)" xref: Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1" xref: Reactome:R-HSA-265301 "Corticotropin cleavage from POMC" xref: Reactome:R-HSA-3244626 "DENV protease NS2B3 cleaves STING" xref: Reactome:R-HSA-3266557 "Factor I cleaves iC3b" xref: Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG" xref: Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8" xref: Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)" xref: Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS" xref: Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1" xref: Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1" xref: Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs" xref: Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB" xref: Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1" xref: Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP" xref: Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP" xref: Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin" xref: Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin" xref: Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)" xref: Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)" xref: Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)" xref: Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va" xref: Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa" xref: Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein" xref: Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer" xref: Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer" xref: Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer" xref: Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)" xref: Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP" xref: Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5" xref: Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2" xref: Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8" xref: Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5" xref: Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)" xref: Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin" xref: Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin" xref: Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)" xref: Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4" xref: Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3" xref: Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2" xref: Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3" xref: Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1" xref: Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))" xref: Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)" xref: Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH" xref: Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS" xref: Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1" xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1" xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2" xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1" xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4" xref: Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin" xref: Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1" xref: Reactome:R-HSA-9662786 "FURIN cleaves ADAM17" xref: Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin" xref: Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L" xref: Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa" xref: Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa" xref: Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)" xref: Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2" xref: Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis" xref: Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2" xref: Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis" xref: Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid" xref: Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis" xref: Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it" xref: Reactome:R-HSA-9710106 "ELANE cleaves GSDMD" xref: Reactome:R-HSA-9710263 "GZMB cleaves GSDME" xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b" xref: Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage" xref: Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion" xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b" xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" xref: Reactome:R-HSA-9816275 "CDH1 is proteolytically cleaved in Golgi" xref: Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane" xref: Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)" xref: Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated" xref: Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane" xref: Reactome:R-HSA-9839367 "TGFBR3_mem cleavage by MMPs" xref: Reactome:R-HSA-9911236 "ELANE cleaves NOTCH2NLA" xref: Reactome:R-HSA-9911383 "LepB cleaves prepro-STa" xref: Reactome:R-HSA-9912368 "LepB cleaves pre-EltA" xref: Reactome:R-HSA-9912371 "LepB cleaves pre-EltB" xref: Reactome:R-HSA-9913329 "Autoproteolysis of DAG1 to alpha and beta chains" xref: Reactome:R-HSA-9918772 "Dengue polyprotein cis-auto-cleaves" xref: Reactome:R-HSA-9918780 "Unknown peptidase cleaves NS1-NS2A" xref: Reactome:R-HSA-9918787 "NS2B3 cleaves C-prM-E-NS1-NS2A" xref: Reactome:R-HSA-9918795 "Signalase cleaves prM-E-NS1-NS2A" xref: Reactome:R-HSA-9918813 "NS2B3 cleaves NS4AB" xref: Reactome:R-HSA-9918817 "NS2B3 cleaves polyprotein" xref: Reactome:R-HSA-9918823 "NS345:NS2B cleaves NS345" xref: Reactome:R-HSA-9918871 "Signalase cleaves prepro-NS4B" xref: Reactome:R-HSA-9918876 "NS2B3 cleaves prepro-C at the C-prM junction" xref: Reactome:R-HSA-9919050 "Furin cleaves prM:E" xref: Reactome:R-HSA-9921595 "NS2B3 cleaves FAM134B" xref: Reactome:R-HSA-9921689 "NS3 cleaves GrpEL1" xref: Reactome:R-HSA-9926936 "EspC(54-1018) cleaves hemoglobin" xref: Reactome:R-HSA-9926963 "Hbp cis-autocleaves" xref: Reactome:R-HSA-9927009 "Hbp(53-1100) cleaves hemoglobin" xref: Reactome:R-HSA-9932162 "Removal of CDH1 signal peptide" xref: Reactome:R-HSA-9947496 "ACOT2 cleaves NS345" is_a: GO:0008233 ! peptidase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.4.21.- property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.1 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.10 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.102 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.20 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.21 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.22 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.26 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.27 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.34 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.35 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.36 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.38 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.39 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.4 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.41 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.42 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.43 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.45 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.46 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.47 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.48 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.5 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.53 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.54 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.59 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.6 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.61 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.62 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.68 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.69 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.7 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.71 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.73 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.75 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.78 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.79 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.83 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.88 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.9 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.92 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.93 property_value: narrowMatch http://purl.uniprot.org/enzyme/3.4.21.94 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20581" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = an ethanediol." [EC:3.3.2.10] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" RELATED [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" RELATED [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: Reactome:R-HSA-2161961 "5,6-EET is hydrolysed to 5,6-DHET by EPHX2" xref: Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1" xref: Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1" xref: Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2" xref: Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4" xref: Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1" xref: Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2" xref: Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4" xref: Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1" xref: Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1" xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2" xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA" xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA" xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA" xref: Reactome:R-HSA-9915968 "8,9-EET is hydrolysed to 8.9-DHET by EPHX2" xref: Reactome:R-HSA-9915986 "11,12-EET is hydrolysed to 11,12-DHET by EPHX2" xref: Reactome:R-HSA-9915994 "14,15-EET is hydrolysed to 14,15-DHET by EPHX2" xref: RHEA:19037 xref: RHEA:44032 xref: RHEA:44036 xref: RHEA:44040 xref: RHEA:44044 xref: RHEA:44048 xref: RHEA:45352 xref: RHEA:53972 xref: RHEA:53976 xref: RHEA:53980 xref: RHEA:53984 xref: RHEA:53992 xref: RHEA:53996 xref: RHEA:54000 xref: RHEA:54004 xref: RHEA:54008 xref: RHEA:54012 xref: RHEA:54016 xref: RHEA:56584 xref: RHEA:80591 xref: RHEA:80779 xref: RHEA:80783 xref: RHEA:80787 xref: RHEA:80791 xref: RHEA:80795 xref: RHEA:80799 xref: RHEA:81855 is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.3.2.10 property_value: exactMatch http://rdf.rhea-db.org/19037 property_value: narrowMatch http://rdf.rhea-db.org/44032 property_value: narrowMatch http://rdf.rhea-db.org/44036 property_value: narrowMatch http://rdf.rhea-db.org/44040 property_value: narrowMatch http://rdf.rhea-db.org/44044 property_value: narrowMatch http://rdf.rhea-db.org/44048 property_value: narrowMatch http://rdf.rhea-db.org/45352 property_value: narrowMatch http://rdf.rhea-db.org/53972 property_value: narrowMatch http://rdf.rhea-db.org/53976 property_value: narrowMatch http://rdf.rhea-db.org/53980 property_value: narrowMatch http://rdf.rhea-db.org/53984 property_value: narrowMatch http://rdf.rhea-db.org/53992 property_value: narrowMatch http://rdf.rhea-db.org/53996 property_value: narrowMatch http://rdf.rhea-db.org/54000 property_value: narrowMatch http://rdf.rhea-db.org/54004 property_value: narrowMatch http://rdf.rhea-db.org/54008 property_value: narrowMatch http://rdf.rhea-db.org/54012 property_value: narrowMatch http://rdf.rhea-db.org/54016 property_value: narrowMatch http://rdf.rhea-db.org/56584 property_value: narrowMatch http://rdf.rhea-db.org/80591 property_value: narrowMatch http://rdf.rhea-db.org/80779 property_value: narrowMatch http://rdf.rhea-db.org/80783 property_value: narrowMatch http://rdf.rhea-db.org/80787 property_value: narrowMatch http://rdf.rhea-db.org/80791 property_value: narrowMatch http://rdf.rhea-db.org/80795 property_value: narrowMatch http://rdf.rhea-db.org/80799 property_value: narrowMatch http://rdf.rhea-db.org/81855 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27074" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004386 name: helicase activity namespace: molecular_function alt_id: GO:0008026 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "ATP-dependent helicase activity" EXACT [] xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding" xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding" xref: Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction" xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA" xref: Reactome:R-HSA-9922957 "NS3 melts (+)-RNA secondary structures" xref: Reactome:R-HSA-9923073 "NS3 unwinds dsRNA secondary structures" is_a: GO:0016853 ! isomerase activity is_a: GO:0140657 ! ATP-dependent activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21393" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29690" xsd:anyURI [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [PMID:11267890, RHEA:16393] subset: goslim_chembl synonym: "JH esterase activity" RELATED [EC:3.1.1.59] synonym: "JH-esterase activity" RELATED [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" RELATED [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" RELATED [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" RELATED [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN xref: RHEA:16393 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.59 property_value: exactMatch http://rdf.rhea-db.org/16393 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the cleavage of ester linkages within nucleic acids." [ISBN:0198547684] comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases. subset: goslim_chembl subset: goslim_drosophila subset: goslim_plant subset: goslim_yeast is_a: GO:0003824 ! catalytic activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24408" xsd:anyURI [Term] id: GO:0004620 name: glycerophospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [PMID:30109646] subset: goslim_chembl synonym: "glycerophospholipid hydrolase activity" EXACT [] synonym: "phospholipase activity" RELATED [] xref: Reactome:R-HSA-6786650 "DDHD1,2 hydrolyse PA" xref: Reactome:R-HSA-6792445 "LIPH, I hydrolyse PA to 2-acyl LPA" is_a: GO:0016298 ! lipase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21843" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30258" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31030" xsd:anyURI [Term] id: GO:0004622 name: phosphatidylcholine lysophospholipase A1 activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [RHEA:15177] subset: goslim_chembl synonym: "2-lysophosphatidylcholine acylhydrolase activity" RELATED [EC:3.1.1.5] synonym: "lecithinase B activity" RELATED [EC:3.1.1.5] synonym: "lecitholipase activity" RELATED [EC:3.1.1.5] synonym: "lysolecithinase activity" RELATED [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" RELATED [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" RELATED [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "lysophospholipase activity" BROAD [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phosphatidylcholine lysophospholipase A1-type activity" EXACT [] synonym: "phospholipase B activity" RELATED [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN xref: Reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: Reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: Reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: Reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: Reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: Reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: Reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho" xref: RHEA:15177 is_a: GO:0004620 ! glycerophospholipase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.5 property_value: exactMatch http://rdf.rhea-db.org/15177 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27557" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30258" xsd:anyURI [Term] id: GO:0004623 name: A2-type glycerophospholipase activity namespace: molecular_function alt_id: GO:0102567 alt_id: GO:0102568 def: "A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [PMID:30109646] subset: goslim_chembl synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" RELATED [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" RELATED [EC:3.1.1.4] synonym: "phospholipase A2 activity" EXACT [] synonym: "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)" NARROW [] synonym: "phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" NARROW [] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN xref: MetaCyc:RXN-15065 xref: MetaCyc:RXN-15067 xref: Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)" xref: Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]" xref: Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A" xref: Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)" xref: Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)" xref: Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]" xref: Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A" xref: Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)" xref: Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]" xref: Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]" xref: Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]" xref: Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" xref: Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]" xref: Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]" xref: Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]" xref: Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]" xref: Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A" xref: Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]" xref: Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]" xref: Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]" xref: Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]" xref: Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1" xref: Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]" xref: Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]" xref: Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane" xref: RHEA:15801 xref: RHEA:38779 xref: RHEA:38847 xref: RHEA:40427 xref: RHEA:40519 xref: RHEA:40643 xref: RHEA:40651 xref: RHEA:40811 xref: RHEA:41223 xref: RHEA:53500 xref: RHEA:56428 xref: RHEA:62036 is_a: GO:0004620 ! glycerophospholipase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.4 property_value: narrowMatch http://identifiers.org/metacyc.reaction/RXN-15065 property_value: narrowMatch http://identifiers.org/metacyc.reaction/RXN-15067 property_value: narrowMatch http://rdf.rhea-db.org/15801 property_value: narrowMatch http://rdf.rhea-db.org/38779 property_value: narrowMatch http://rdf.rhea-db.org/38847 property_value: narrowMatch http://rdf.rhea-db.org/40427 property_value: narrowMatch http://rdf.rhea-db.org/40519 property_value: narrowMatch http://rdf.rhea-db.org/40643 property_value: narrowMatch http://rdf.rhea-db.org/40651 property_value: narrowMatch http://rdf.rhea-db.org/40811 property_value: narrowMatch http://rdf.rhea-db.org/41223 property_value: narrowMatch http://rdf.rhea-db.org/53500 property_value: narrowMatch http://rdf.rhea-db.org/56428 property_value: narrowMatch http://rdf.rhea-db.org/62036 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21259" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30258" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31049" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31198" xsd:anyURI [Term] id: GO:0004630 name: D-type glycerophospholipase activity namespace: molecular_function def: "A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid." [PMID:30109646] subset: goslim_chembl synonym: "choline phosphatase activity" RELATED [EC:3.1.4.4] synonym: "D-type phospholipase activity" EXACT [] synonym: "lecithinase D activity" RELATED [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" RELATED [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" RELATED [EC:3.1.4.4] synonym: "phospholipase D activity" EXACT [] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6" xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2" xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD" xref: RHEA:14445 xref: RHEA:41412 xref: RHEA:41416 is_a: GO:0004620 ! glycerophospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.4.4 property_value: narrowMatch http://rdf.rhea-db.org/14445 property_value: narrowMatch http://rdf.rhea-db.org/41412 property_value: narrowMatch http://rdf.rhea-db.org/41416 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31049" xsd:anyURI [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+." [EC:3.1.4.12, RHEA:19253] subset: goslim_chembl synonym: "sphingomyelin cholinephosphohydrolase activity" RELATED [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: KEGG_REACTION:R02541 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM" xref: Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)" xref: Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)" xref: Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin" xref: Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets" xref: RHEA:19253 xref: RHEA:45324 xref: RHEA:54284 is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0016298 ! lipase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.4.12 property_value: exactMatch http://rdf.rhea-db.org/19253 property_value: narrowMatch http://rdf.rhea-db.org/45324 property_value: narrowMatch http://rdf.rhea-db.org/54284 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31030" xsd:anyURI [Term] id: GO:0004771 name: sterol ester esterase activity namespace: molecular_function def: "Catalysis of the reaction: a sterol ester + H2O = a fatty acid + a sterol + H+." [RHEA:10100] subset: goslim_chembl synonym: "acylcholesterol lipase activity" RELATED [EC:3.1.1.13] synonym: "cholesterase activity" RELATED [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" RELATED [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" RELATED [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" RELATED [EC:3.1.1.13] synonym: "cholesteryl esterase activity" RELATED [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" RELATED [EC:3.1.1.13] synonym: "sterol esterase activity" EXACT [] synonym: "steryl-ester acylhydrolase activity" RELATED [EC:3.1.1.13] synonym: "triterpenol esterase activity" RELATED [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters" xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids" xref: RHEA:10100 xref: RHEA:33543 xref: RHEA:33547 xref: RHEA:33875 xref: RHEA:36403 is_a: GO:0016298 ! lipase activity property_value: exactMatch http://identifiers.org/metacyc.reaction/STEROL-ESTERASE-RXN property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.13 property_value: exactMatch http://rdf.rhea-db.org/10100 property_value: narrowMatch http://rdf.rhea-db.org/33543 property_value: narrowMatch http://rdf.rhea-db.org/33547 property_value: narrowMatch http://rdf.rhea-db.org/33875 property_value: narrowMatch http://rdf.rhea-db.org/36403 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI [Term] id: GO:0004806 name: triacylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+." [RHEA:12044] subset: goslim_chembl synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" RELATED [EC:3.1.1.3] synonym: "cacordase activity" RELATED [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" RELATED [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" RELATED [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "TAG activity" EXACT [PMID:16054079] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" RELATED [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" RELATED [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" RELATED [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" RELATED [EC:3.1.1.3] synonym: "tributyrinase activity" RELATED [EC:3.1.1.3] synonym: "triglyceridase activity" RELATED [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" RELATED [EC:3.1.1.3] synonym: "triglyceride lipase activity" EXACT [] synonym: "triolein hydrolase activity" RELATED [EC:3.1.1.3] synonym: "tween hydrolase activity" RELATED [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" RELATED [EC:3.1.1.3] synonym: "tweenase activity" RELATED [EC:3.1.1.3] synonym: "tweenesterase activity" RELATED [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:RXN-19278 xref: Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3" xref: Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid" xref: Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA" xref: Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG" xref: Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG" xref: RHEA:12044 xref: RHEA:33271 xref: RHEA:35667 xref: RHEA:38379 xref: RHEA:38387 xref: RHEA:38391 xref: RHEA:38395 xref: RHEA:38399 xref: RHEA:38403 xref: RHEA:38407 xref: RHEA:38411 xref: RHEA:38415 xref: RHEA:38419 xref: RHEA:38423 xref: RHEA:38427 xref: RHEA:38431 xref: RHEA:38495 xref: RHEA:38499 xref: RHEA:38575 xref: RHEA:39931 xref: RHEA:40047 xref: RHEA:40055 xref: RHEA:40475 xref: RHEA:40611 xref: RHEA:40615 xref: RHEA:40619 xref: RHEA:40623 xref: RHEA:40627 xref: RHEA:40631 xref: RHEA:43732 xref: RHEA:44864 xref: RHEA:47864 xref: RHEA:48024 xref: RHEA:48028 xref: RHEA:59020 xref: RHEA:59024 xref: RHEA:63432 xref: RHEA:63436 is_a: GO:0016298 ! lipase activity property_value: broadMatch http://purl.uniprot.org/enzyme/3.1.1.79 property_value: exactMatch http://identifiers.org/metacyc.reaction/RXN-19278 property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.3 property_value: exactMatch http://rdf.rhea-db.org/12044 property_value: narrowMatch http://rdf.rhea-db.org/33271 property_value: narrowMatch http://rdf.rhea-db.org/35667 property_value: narrowMatch http://rdf.rhea-db.org/38379 property_value: narrowMatch http://rdf.rhea-db.org/38387 property_value: narrowMatch http://rdf.rhea-db.org/38391 property_value: narrowMatch http://rdf.rhea-db.org/38395 property_value: narrowMatch http://rdf.rhea-db.org/38399 property_value: narrowMatch http://rdf.rhea-db.org/38403 property_value: narrowMatch http://rdf.rhea-db.org/38407 property_value: narrowMatch http://rdf.rhea-db.org/38411 property_value: narrowMatch http://rdf.rhea-db.org/38415 property_value: narrowMatch http://rdf.rhea-db.org/38419 property_value: narrowMatch http://rdf.rhea-db.org/38423 property_value: narrowMatch http://rdf.rhea-db.org/38427 property_value: narrowMatch http://rdf.rhea-db.org/38431 property_value: narrowMatch http://rdf.rhea-db.org/38495 property_value: narrowMatch http://rdf.rhea-db.org/38499 property_value: narrowMatch http://rdf.rhea-db.org/38575 property_value: narrowMatch http://rdf.rhea-db.org/39931 property_value: narrowMatch http://rdf.rhea-db.org/40047 property_value: narrowMatch http://rdf.rhea-db.org/40055 property_value: narrowMatch http://rdf.rhea-db.org/40475 property_value: narrowMatch http://rdf.rhea-db.org/40611 property_value: narrowMatch http://rdf.rhea-db.org/40615 property_value: narrowMatch http://rdf.rhea-db.org/40619 property_value: narrowMatch http://rdf.rhea-db.org/40623 property_value: narrowMatch http://rdf.rhea-db.org/40627 property_value: narrowMatch http://rdf.rhea-db.org/40631 property_value: narrowMatch http://rdf.rhea-db.org/43732 property_value: narrowMatch http://rdf.rhea-db.org/44864 property_value: narrowMatch http://rdf.rhea-db.org/47864 property_value: narrowMatch http://rdf.rhea-db.org/48024 property_value: narrowMatch http://rdf.rhea-db.org/48028 property_value: narrowMatch http://rdf.rhea-db.org/59020 property_value: narrowMatch http://rdf.rhea-db.org/59024 property_value: narrowMatch http://rdf.rhea-db.org/63432 property_value: narrowMatch http://rdf.rhea-db.org/63436 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein] subset: goslim_chembl is_a: GO:0003674 ! molecular_function relationship: has_part GO:0003674 ! molecular_function relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13" xref: Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq" xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)" xref: Wikipedia:GPCR is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0007165 ! signal transduction [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. subset: goslim_chembl synonym: "macrophage receptor activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0003674 ! molecular_function relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0005086 alt_id: GO:0005087 alt_id: GO:0005088 alt_id: GO:0005089 alt_id: GO:0005090 alt_id: GO:0008321 alt_id: GO:0008433 alt_id: GO:0016219 alt_id: GO:0016220 alt_id: GO:0017034 alt_id: GO:0017112 alt_id: GO:0017132 alt_id: GO:0019839 alt_id: GO:0030676 def: "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "ARF guanyl-nucleotide exchange factor activity" NARROW [] synonym: "cAMP-dependent guanyl-nucleotide exchange factor activity" NARROW [] synonym: "GDP-dissociation stimulator activity" EXACT [] synonym: "GDS" EXACT [] synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] synonym: "Rab guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Rac guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Ral guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Ran guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Rap guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Ras guanyl-nucleotide exchange factor activity" NARROW [] synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "Rho guanyl-nucleotide exchange factor activity" NARROW [] synonym: "RhoGEF" EXACT [] synonym: "Sar guanyl-nucleotide exchange factor activity" NARROW [] xref: Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA" xref: Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP" xref: Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)" xref: Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)" xref: Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4" xref: Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers" xref: Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers" xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers" xref: Reactome:R-HSA-1433415 "Activation of RAC1" xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1" xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity" xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL" xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)" xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP" xref: Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)" xref: Reactome:R-HSA-187746 "RIT/RIN are activated" xref: Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth" xref: Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP" xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV" xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO" xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding" xref: Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor" xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)" xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)" xref: Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3" xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)" xref: Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt" xref: Reactome:R-HSA-2730840 "Activation of RAC1 by VAV" xref: Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation" xref: Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs" xref: Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs" xref: Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11" xref: Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi" xref: Reactome:R-HSA-381727 "RAP1A exchanges GDP for GTP" xref: Reactome:R-HSA-389348 "Activation of Rac1 by pVav1" xref: Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1" xref: Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras" xref: Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12" xref: Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it" xref: Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it" xref: Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it" xref: Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA" xref: Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor" xref: Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange" xref: Reactome:R-HSA-399938 "Activation of Rac1 by FARP2" xref: Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq" xref: Reactome:R-HSA-400037 "Gi,Go Heterotrimeric G-protein complex dissociates" xref: Reactome:R-HSA-400092 "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins" xref: Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-416530 "FFAR1:FFAR1 ligands activate Gq" xref: Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF" xref: Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1" xref: Reactome:R-HSA-418850 "Activation of Cdc42" xref: Reactome:R-HSA-418856 "Activation of Rac1" xref: Reactome:R-HSA-419166 "GEFs activate RhoA,B,C" xref: Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t" xref: Reactome:R-HSA-428535 "Activation of RAC1 by SOS" xref: Reactome:R-HSA-428750 "Gq activation by TP receptor" xref: Reactome:R-HSA-428917 "G13 activation by TP receptor" xref: Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases" xref: Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases" xref: Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases" xref: Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS" xref: Reactome:R-HSA-445064 "Activation of Rac1 by VAV2" xref: Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism" xref: Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1" xref: Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4" xref: Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)" xref: Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)" xref: Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655277 "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange" xref: Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1" xref: Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange" xref: Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF" xref: Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane" xref: Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange" xref: Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz" xref: Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13" xref: Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange" xref: Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex" xref: Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18" xref: Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1" xref: Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET" xref: Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET" xref: Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A" xref: Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5" xref: Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1" xref: Reactome:R-HSA-8875591 "DOCK7 activates RAC1" xref: Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10" xref: Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8" xref: Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9" xref: Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6" xref: Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12" xref: Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13" xref: Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14" xref: Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21" xref: Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27" xref: Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31" xref: Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7" xref: Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1" xref: Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35" xref: Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38" xref: Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39" xref: Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18" xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated" xref: Reactome:R-HSA-8980691 "RHOA GEFs activate RHOA" xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t" xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)" xref: Reactome:R-HSA-9013023 "RHOB GEFs activate RHOB" xref: Reactome:R-HSA-9013109 "RHOC GEFs activate RHOC" xref: Reactome:R-HSA-9013143 "RAC1 GEFs activate RAC1" xref: Reactome:R-HSA-9013159 "CDC42 GEFs activate CDC42" xref: Reactome:R-HSA-9013435 "RHOD auto-activates" xref: Reactome:R-HSA-9014296 "RAC2 GEFs activate RAC2" xref: Reactome:R-HSA-9014433 "RHOG GEFs activate RHOG" xref: Reactome:R-HSA-9017491 "RHOJ GEFs activate RHOJ" xref: Reactome:R-HSA-9018747 "RHOQ GEFs activate RHOQ" xref: Reactome:R-HSA-9018768 "RHOU auto-activates" xref: Reactome:R-HSA-9018804 "RAC3 GEFs activate RAC3" xref: Reactome:R-HSA-9018817 "RHOT1 GEFs activate RHOT1" xref: Reactome:R-HSA-9018825 "RHOT2 GEFs activate RHOT2" xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1" xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS" xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2" xref: Reactome:R-HSA-9032798 "DOCK3 activates RAC1" xref: Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1" xref: Reactome:R-HSA-9036301 "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s" xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs" xref: Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3" xref: Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1" xref: Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN" xref: Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1" xref: Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP" xref: Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP" xref: Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs" xref: Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants" xref: Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR" xref: Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1" xref: Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2" xref: Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants" xref: Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR" xref: Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP" xref: Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP" xref: Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS" xref: Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers" xref: Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors" xref: Reactome:R-HSA-9680385 "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS" xref: Reactome:R-HSA-9693111 "RHOF auto-activates" xref: Reactome:R-HSA-9695853 "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS" xref: Reactome:R-HSA-9703441 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants" xref: Reactome:R-HSA-9751201 "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1" is_a: GO:0030234 ! enzyme regulator activity relationship: negatively_regulates GO:0000166 ! nucleotide binding relationship: negatively_regulates GO:0043167 ! ion binding relationship: positively_regulates GO:0000166 ! nucleotide binding relationship: positively_regulates GO:0043167 ! ion binding relationship: regulates GO:0000166 ! nucleotide binding relationship: regulates GO:0003924 ! GTPase activity relationship: regulates GO:0043167 ! ion binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18749" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18750" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27684" xsd:anyURI [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function alt_id: GO:0005110 def: "Binding to a frizzled (fz) receptor." [GOC:ceb] subset: goslim_chembl synonym: "frizzled ligand" NARROW [] synonym: "frizzled-2 binding" NARROW [] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] synonym: "fz2 binding" NARROW [] synonym: "fz2 ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] subset: goslim_chembl synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802] subset: goslim_chembl synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] synonym: "phytocytokine activity" NARROW [PMID:23072994] is_a: GO:0048018 ! receptor ligand activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19116" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29424" xsd:anyURI [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Binding to an interleukin-5 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Binding to an interleukin-6 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Binding to an interleukin-8 receptor." [GOC:curators] subset: goslim_chembl synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Binding to an epidermal growth factor receptor." [GOC:ai] subset: goslim_chembl synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Binding to a tumor necrosis factor receptor." [GOC:ai] subset: goslim_chembl synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Binding to an integrin." [GOC:ceb] subset: goslim_chembl synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] subset: goslim_chembl synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast is_a: GO:0003674 ! molecular_function property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24130" xsd:anyURI [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "carrier" RELATED [] is_a: GO:0003674 ! molecular_function property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27621" xsd:anyURI [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] subset: goslim_chembl synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0030674 ! protein-macromolecule adaptor activity relationship: part_of GO:0003674 ! molecular_function relationship: part_of GO:0061024 ! membrane organization property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31564" xsd:anyURI [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Binding to a protein." [GOC:curators] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: goslim_chembl xref: Reactome:R-HSA-202110 "eNOS:Caveolin-1 complex binds to CaM" is_a: GO:0005515 ! protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732] subset: goslim_chembl synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005537 name: D-mannose binding namespace: molecular_function def: "Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981] subset: goslim_chembl synonym: "mannose binding" BROAD [] synonym: "mannose binding lectin" RELATED [] xref: Reactome:R-HSA-947991 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi" is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0003674 ! molecular_function [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17729" xsd:anyURI [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31545" xsd:anyURI [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, ISBN:0198547684, PMID:15134259, Wikipedia:Microbial_cyst] comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995). subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21669" xsd:anyURI [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0005575 ! cellular_component property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17776" xsd:anyURI [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:curators] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005634 ! nucleus property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29832" xsd:anyURI [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043226 ! organelle relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23023" xsd:anyURI [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0005773 ! vacuole [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "peroxisomal" RELATED [] synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732, PMID:9695800] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14798" xsd:anyURI [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17777" xsd:anyURI [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005887 alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "integral component of plasma membrane" NARROW [] synonym: "integral to plasma membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: has_part GO:0032991 ! protein-containing complex [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22880" xsd:anyURI created_by: jl creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_chembl subset: goslim_yeast synonym: "mRNA maturation" RELATED [] is_a: GO:0008152 ! metabolic process relationship: part_of GO:0009058 ! biosynthetic process [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "tRNA metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:curators] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "protein translation" EXACT [] xref: Reactome:R-HSA-72766 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0009058 ! biosynthetic process relationship: has_part GO:0009058 ! biosynthetic process relationship: has_part GO:0016746 ! acyltransferase activity relationship: has_part GO:0022618 ! protein-RNA complex assembly relationship: part_of GO:0009058 ! biosynthetic process [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:curators, GOC:rb] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:R-HSA-389960 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:R-HSA-390450 "Folding of actin by CCT/TriC" xref: Reactome:R-HSA-390466 "Chaperonin-mediated protein folding" xref: Reactome:R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" xref: Wikipedia:Protein_folding is_a: GO:0008150 ! biological_process relationship: part_of GO:0051604 ! protein maturation property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25673" xsd:anyURI [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0008152 ! metabolic process [Term] id: GO:0006520 name: amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "amino acid and derivative metabolism" RELATED [] synonym: "cellular amino acid and derivative metabolic process" RELATED [] synonym: "cellular amino acid metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] subset: goslim_chembl subset: goslim_pombe subset: goslim_yeast synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26248" xsd:anyURI [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:R-HSA-556833 "Metabolism of lipids" xref: Wikipedia:Lipid_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process alt_id: GO:0017144 def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc] subset: goslim_chembl subset: goslim_pir synonym: "drug metabolic process" RELATED [] synonym: "drug metabolism" RELATED [] synonym: "xenobiotic metabolism" EXACT [] xref: Reactome:R-HSA-211859 "Biological oxidations" xref: Reactome:R-HSA-211981 "Xenobiotics" xref: Reactome:R-HSA-2161541 "Abacavir metabolism" xref: Reactome:R-HSA-9748784 "Drug ADME" xref: Wikipedia:Drug_metabolism xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0008152 ! metabolic process relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19460" xsd:anyURI [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "single-organism transport" RELATED [] xref: Reactome:R-HSA-382551 "Transport of small molecules" is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20292" xsd:anyURI created_by: jl creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Reactome:R-HSA-9612973 "Autophagy" xref: Wikipedia:Autophagy_(cellular) is_a: GO:0009056 ! catabolic process relationship: has_part GO:0055085 ! transmembrane transport property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25541" xsd:anyURI [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26810" xsd:anyURI [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrial biogenesis" EXACT [] synonym: "mitochondrial organization" EXACT [] synonym: "mitochondrion biogenesis" EXACT [] synonym: "mitochondrion morphogenesis" RELATED [] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [] xref: Reactome:R-HSA-1592230 "Mitochondrial biogenesis" is_a: GO:0008150 ! biological_process [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell-division cycle" EXACT [] xref: Reactome:R-HSA-1640170 "Cell Cycle" xref: Wikipedia:Cell_cycle is_a: GO:0008150 ! biological_process [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0008150 ! biological_process relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0008150 ! biological_process created_by: dos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023014 alt_id: GO:0023015 alt_id: GO:0023016 alt_id: GO:0023033 alt_id: GO:0023045 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [] xref: Reactome:R-HSA-212718 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant is_a: GO:0048856 ! anatomical structure development property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21234" xsd:anyURI [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0022414 ! reproductive process [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Reactome:R-HSA-8935690 "Digestion" xref: Wikipedia:Digestion is_a: GO:0008150 ! biological_process [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine] subset: goslim_chembl is_a: GO:0005102 ! signaling receptor binding is_a: GO:0005125 ! cytokine activity relationship: part_of GO:0040011 ! locomotion relationship: part_of GO:0048870 ! cell motility [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-] subset: goslim_chembl synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4.- xref: Reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.4.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] synonym: "transcription regulator binding" RELATED [] is_a: GO:0005515 ! protein binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19354" xsd:anyURI [Term] id: GO:0008135 name: translation factor activity, RNA binding namespace: molecular_function def: "Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] subset: goslim_chembl subset: goslim_plant subset: goslim_yeast synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0003723 ! RNA binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2.-] subset: goslim_chembl synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2.- xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP" xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP" xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP" xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate" xref: Reactome:R-HSA-9753277 "SULT dimers sulfate APAP to APAP-SO3" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.- [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24968" xsd:anyURI created_by: jl creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote_ribbon synonym: "metabolism" EXACT [] xref: Reactome:R-HSA-1430728 "Metabolism" xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI created_by: jl creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "methylase" BROAD [] xref: EC:2.1.1.- xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT" xref: Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA" xref: Reactome:R-HSA-5333608 "GSSebGalNac is reduced and methylated to MeSebGalNac" xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII" xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine" xref: Reactome:R-HSA-9710490 "The GSDME gene promoter is hypermethylated" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.1.1.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Bioluminescence is_a: GO:0008152 ! metabolic process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function alt_id: GO:0070010 alt_id: GO:0070011 def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [EC:3.4.-.-, GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4.-.- xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl" xref: Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl" xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" xref: Reactome:R-HSA-9935547 "Lysosomal degradation of ubiqutinated CDH1" is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.4.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Binding to a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast is_a: GO:0003674 ! molecular_function [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] subset: goslim_chembl synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: Reactome:R-HSA-203613 "Depalmitoylation of eNOS" xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins" xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43" xref: Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated" xref: RHEA:19233 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0008152 ! metabolic process property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.2.22 property_value: exactMatch http://rdf.rhea-db.org/19233 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" RELATED [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" RELATED [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2" xref: Reactome:R-HSA-9668023 "TPST1,2 transfer SO4(2-) from PAPS to FVIII" xref: Reactome:R-HSA-9668148 "F8 variant is not sulfonated at Y1699" xref: RHEA:16801 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.20 property_value: exactMatch http://rdf.rhea-db.org/16801 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP." [RHEA:21920] comment: Note that EC classifies all three 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under EC:2.7.8.13. subset: goslim_chembl synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" RELATED [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" RELATED [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" RELATED [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" RELATED [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" RELATED [EC:2.7.8.13] xref: MetaCyc:RXN-8975 xref: RHEA:21920 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: broadMatch http://purl.uniprot.org/enzyme/2.7.8.13 property_value: exactMatch http://rdf.rhea-db.org/21920 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI [Term] id: GO:0008970 name: glycerophospholipid phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H+. Note that the substrate has a diacyl group attached to the glycerol group." [RHEA:67424] subset: goslim_chembl synonym: "diacylphospholipase A1 activity" BROAD [] synonym: "phosphatidylcholine 1-acylhydrolase activity" NARROW [] synonym: "phosphatidylserine 1-acylhydrolase activity" NARROW [] synonym: "phospholipase A1 activity" RELATED [] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN xref: Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C" xref: Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]" xref: Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)" xref: Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]" xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C" xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]" xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]" xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC" xref: Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS" xref: RHEA:18689 xref: RHEA:35263 xref: RHEA:38783 xref: RHEA:38787 xref: RHEA:40487 xref: RHEA:41167 xref: RHEA:41171 xref: RHEA:41207 xref: RHEA:41320 xref: RHEA:42212 xref: RHEA:43968 xref: RHEA:44408 xref: RHEA:44648 xref: RHEA:53496 xref: RHEA:56448 xref: RHEA:62032 xref: RHEA:62044 xref: RHEA:62464 xref: RHEA:62480 xref: RHEA:62484 xref: RHEA:62488 xref: RHEA:66708 xref: RHEA:67424 xref: RHEA:67428 xref: RHEA:73967 xref: RHEA:73971 xref: RHEA:73975 xref: RHEA:74103 xref: RHEA:74159 xref: RHEA:74163 xref: RHEA:74247 xref: RHEA:74251 xref: RHEA:76971 xref: RHEA:76975 xref: RHEA:76979 xref: RHEA:76983 is_a: GO:0004620 ! glycerophospholipase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.32 property_value: exactMatch http://rdf.rhea-db.org/67424 property_value: narrowMatch http://rdf.rhea-db.org/18689 property_value: narrowMatch http://rdf.rhea-db.org/35263 property_value: narrowMatch http://rdf.rhea-db.org/38783 property_value: narrowMatch http://rdf.rhea-db.org/38787 property_value: narrowMatch http://rdf.rhea-db.org/40487 property_value: narrowMatch http://rdf.rhea-db.org/41167 property_value: narrowMatch http://rdf.rhea-db.org/41171 property_value: narrowMatch http://rdf.rhea-db.org/41207 property_value: narrowMatch http://rdf.rhea-db.org/41320 property_value: narrowMatch http://rdf.rhea-db.org/42212 property_value: narrowMatch http://rdf.rhea-db.org/43968 property_value: narrowMatch http://rdf.rhea-db.org/44408 property_value: narrowMatch http://rdf.rhea-db.org/44648 property_value: narrowMatch http://rdf.rhea-db.org/53496 property_value: narrowMatch http://rdf.rhea-db.org/56448 property_value: narrowMatch http://rdf.rhea-db.org/62032 property_value: narrowMatch http://rdf.rhea-db.org/62044 property_value: narrowMatch http://rdf.rhea-db.org/62464 property_value: narrowMatch http://rdf.rhea-db.org/62480 property_value: narrowMatch http://rdf.rhea-db.org/62484 property_value: narrowMatch http://rdf.rhea-db.org/62488 property_value: narrowMatch http://rdf.rhea-db.org/66708 property_value: narrowMatch http://rdf.rhea-db.org/67428 property_value: narrowMatch http://rdf.rhea-db.org/73967 property_value: narrowMatch http://rdf.rhea-db.org/73971 property_value: narrowMatch http://rdf.rhea-db.org/73975 property_value: narrowMatch http://rdf.rhea-db.org/74103 property_value: narrowMatch http://rdf.rhea-db.org/74159 property_value: narrowMatch http://rdf.rhea-db.org/74163 property_value: narrowMatch http://rdf.rhea-db.org/74247 property_value: narrowMatch http://rdf.rhea-db.org/74251 property_value: narrowMatch http://rdf.rhea-db.org/76971 property_value: narrowMatch http://rdf.rhea-db.org/76975 property_value: narrowMatch http://rdf.rhea-db.org/76979 property_value: narrowMatch http://rdf.rhea-db.org/76983 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_plant subset: goslim_plant_ribbon synonym: "breakdown of chemical" EXACT [] synonym: "breakdown of molecule" EXACT [] synonym: "breakdown of substance" EXACT [] synonym: "catabolism" EXACT [] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28921" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29627" xsd:anyURI created_by: jl creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI created_by: jl creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process alt_id: GO:0044106 def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Plastid is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/13958" xsd:anyURI [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: goslim_chembl synonym: "cytokinin metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Reactome:R-HSA-5619507 "Activation of HOX genes during differentiation" xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate subset: goslim_chembl xref: Reactome:R-HSA-5218900 "CASP8 activity is inhibited" is_a: GO:0050790 ! regulation of catalytic activity relationship: negatively_regulates GO:0006508 ! proteolysis relationship: negatively_regulates GO:0008233 ! peptidase activity relationship: regulates GO:0006508 ! proteolysis relationship: regulates GO:0008233 ! peptidase activity created_by: tb creation_date: 2009-04-27T11:47:01Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Reactome:R-HSA-5357801 "Programmed Cell Death" xref: Wikipedia:Programmed_cell_death is_a: GO:0008150 ! biological_process relationship: has_part GO:0007165 ! signal transduction property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24835" xsd:anyURI [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0015976 name: carbon utilization namespace: biological_process alt_id: GO:0015978 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: goslim_chembl subset: goslim_pir synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] synonym: "heterotrophy" EXACT [] xref: Wikipedia:Heterotroph is_a: GO:0008150 ! biological_process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: Wikipedia:Photosynthesis is_a: GO:0008152 ! metabolic process [Term] id: GO:0016020 name: membrane namespace: cellular_component alt_id: GO:0016021 alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "integral component of membrane" NARROW [] synonym: "integral to membrane" NARROW [] synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane xref: Wikipedia:Transmembrane_protein is_a: GO:0005575 ! cellular_component creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25421" xsd:anyURI [Term] id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila xref: Reactome:R-HSA-163402 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid" xref: Reactome:R-HSA-163432 "cholesterol ester + H2O -> cholesterol + fatty acid" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21843" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: gocheck_obsoletion_candidate subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0016485 name: protein processing namespace: biological_process alt_id: GO:0051605 def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] xref: Reactome:R-HSA-159782 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:R-HSA-9033500 "TYSND1 cleaves peroxisomal proteins" is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1.-.-.- xref: Reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" xref: Reactome:R-HSA-2161612 "PGH2 is reduced to PGF2a by FAM213B" xref: Reactome:R-HSA-265296 "Arachidonate is oxidised to 5S-HpETE by ALOX5" xref: Reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5" xref: Reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds" xref: Reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" xref: Reactome:R-HSA-9020260 "Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5" xref: Reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" xref: Reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" xref: Reactome:R-HSA-9693722 "Unknown sepiapterin synthase transforms PTHP to sepiapterin" xref: Reactome:R-HSA-9759549 "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin" is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/1.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016540 name: protein autoprocessing namespace: biological_process def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] subset: goslim_chembl is_a: GO:0016485 ! protein processing [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5333607 "GSSeH combines with bGalNAc derivative to form GSSebGalNac" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016746 name: acyltransferase activity namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] subset: goslim_chembl subset: goslim_drosophila synonym: "transferase activity, transferring acyl groups" EXACT [] xref: EC:2.3.-.- xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.3.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20486" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016757 name: glycosyltransferase activity namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "transferase activity, transferring glycosyl groups" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4.-.- xref: Reactome:R-HSA-5173005 "B3GALTL transfers glucose to O-fucosyl-proteins" xref: Reactome:R-HSA-6785565 "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.4.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [EC:2.5.1.-] subset: goslim_chembl subset: goslim_drosophila synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5.1.- xref: Reactome:R-HSA-3095889 "MMACHC dealkylates RCbl" xref: Reactome:R-HSA-4419978 "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP" xref: Reactome:R-HSA-4755545 "Defective DHDDS does not elongate E,E-FPP" xref: Reactome:R-HSA-6782893 "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.5.1.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [EC:2.7.-.-] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7.-.- xref: Reactome:R-HSA-9932322 "BcsG transfers pEtN from PE onto cellulose" is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.7.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor)." [EC:2.7.7.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7.- xref: Reactome:R-HSA-6782434 "THG1L transfers GMP to 5' end of tRNA(His)" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: exactMatch http://purl.uniprot.org/enzyme/2.7.7.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" xref: Reactome:R-HSA-9942295 "QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate" is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: goslim_chembl synonym: "esterase activity" EXACT [] xref: EC:3.1.-.- xref: Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid" xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-" is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate." [GOC:curators, GOC:pg] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] xref: EC:3.1.3.- xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P" xref: Reactome:R-HSA-9837419 "PANK4 hydrolyzes PPANT to pantetheine" xref: Reactome:R-HSA-9940993 "PXYLP1 dephosphorylates Xyl moiety" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.3.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25755" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2.-.- xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" xref: Reactome:R-HSA-5333609 "MeSebGalNac is hydrolysed to MeSeH and bGalNac" is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.2.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [EC:3.5.-.-] subset: goslim_chembl subset: goslim_drosophila synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5.-.- xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine" is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.5.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast xref: EC:4.-.-.- xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL" xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/4.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5.-.-.- xref: Reactome:R-HSA-2161666 "PGA2 is isomerised to PGC2" xref: Reactome:R-HSA-2161735 "PGC2 is isomerised to PGB2" xref: Reactome:R-HSA-6787623 "GFUS dimer epimerises GDP-DHDMan to GDP-KDGal" is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/5.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6.-.-.- is_a: GO:0003824 ! catalytic activity property_value: exactMatch http://purl.uniprot.org/enzyme/6.-.-.- property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19380" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0016936 name: galactoside binding namespace: molecular_function def: "Binding to a glycoside in which the sugar group is galactose." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0003674 ! molecular_function [Term] id: GO:0017111 name: ribonucleoside triphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [] synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" BROAD [] synonym: "nucleoside triphosphate hydrolase activity" BROAD [] synonym: "nucleoside triphosphate phosphatase activity" BROAD [] synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-triphosphatase activity" BROAD [] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 xref: RHEA:64900 xref: RHEA:65580 is_a: GO:0016787 ! hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.6.1.15 property_value: exactMatch http://rdf.rhea-db.org/23680 property_value: narrowMatch http://rdf.rhea-db.org/64900 property_value: narrowMatch http://rdf.rhea-db.org/65580 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21232" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23401" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0017147 name: Wnt-protein binding namespace: molecular_function def: "Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0018738 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+." [EC:3.1.2.12, RHEA:14961] subset: goslim_chembl xref: EC:3.1.2.12 xref: KEGG_REACTION:R00527 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: Reactome:R-HSA-5693724 "ESD dimer hydrolyses S-FGSH to GSH" xref: RHEA:14961 xref: UM-BBD_reactionID:r0241 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.2.12 property_value: exactMatch http://rdf.rhea-db.org/14961 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0019013 name: viral nucleocapsid namespace: cellular_component alt_id: GO:0019014 def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] subset: goslim_chembl synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] is_a: GO:0044423 ! virion component relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0019028 name: viral capsid namespace: cellular_component alt_id: GO:0046728 def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_chembl subset: goslim_virus xref: Wikipedia:Capsid is_a: GO:0044423 ! virion component [Term] id: GO:0019031 name: viral envelope namespace: cellular_component def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] subset: goslim_chembl synonym: "viral glycoprotein" RELATED [] synonym: "viral outside membrane" EXACT [] xref: Wikipedia:Viral_envelope is_a: GO:0044423 ! virion component [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:curators] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0008150 ! biological_process [Term] id: GO:0019838 name: growth factor binding namespace: molecular_function def: "Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] subset: goslim_chembl synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019843 name: rRNA binding namespace: molecular_function alt_id: GO:0000944 def: "Binding to a ribosomal RNA." [GOC:jl] subset: goslim_chembl subset: goslim_yeast synonym: "base pairing with rRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0019864 name: IgG binding namespace: molecular_function def: "Binding to an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149] subset: goslim_chembl is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] subset: goslim_chembl subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0019904 name: protein domain specific binding namespace: molecular_function def: "Binding to a specific domain of a protein." [GOC:curators] subset: goslim_chembl synonym: "protein domain-specific binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] subset: goslim_chembl is_a: GO:0008150 ! biological_process [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0019952 alt_id: GO:0044702 alt_id: GO:0050876 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "single organism reproductive process" RELATED [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI created_by: jl creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0022618 name: protein-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl synonym: "ribonucleoprotein complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" xref: Reactome:R-HSA-561041 "OAT1,2,3 transport organic anions with antiport of dicarboxylic acids" xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" xref: Reactome:R-HSA-8954513 "NAASP translocates from mitochondrial matrix to cytosol" xref: Reactome:R-HSA-9794270 "SLCO1A2 transports Cipro(1+) into the cytosol" xref: Reactome:R-HSA-9794523 "SLC22A1 transports Cipro into renal cell" xref: Reactome:R-HSA-9794830 "SLC22A8 transports Cipro into renal cell" xref: Reactome:R-HSA-9795207 "SLC22A1 transports Cipro into hepatic cell" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Cellular_differentiation is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI [Term] id: GO:0030169 name: low-density lipoprotein particle binding namespace: molecular_function def: "Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] subset: goslim_chembl synonym: "LDL binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] xref: Reactome:R-HSA-1474244 "Extracellular matrix organization" is_a: GO:0008150 ! biological_process [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function alt_id: GO:0010576 def: "A molecular function regulator that modulates a catalytic activity." [GOC:pdt] comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] synonym: "metalloenzyme regulator activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005515 ! protein binding relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005576 ! extracellular region property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31720" xsd:anyURI [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_candida subset: goslim_chembl subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0003729 ! mRNA binding relationship: has_part GO:0003674 ! molecular_function relationship: part_of GO:0006412 ! translation [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0030674 name: protein-macromolecule adaptor activity namespace: molecular_function def: "An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] comment: Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity. subset: goslim_chembl subset: goslim_yeast synonym: "protein binding, bridging" EXACT [] synonym: "protein recruiting activity" RELATED [] synonym: "protein-protein adaptor" NARROW [] xref: Reactome:R-HSA-3780997 "PPP1R3C binds to glycogen:GYG2:GYS2" xref: Reactome:R-HSA-3781001 "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex" xref: Reactome:R-HSA-3781021 "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex" xref: Reactome:R-HSA-3781023 "PPP1R3C binds to glycogen:GYG1:GYS1" xref: Reactome:R-HSA-8871366 "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP" xref: Reactome:R-HSA-8871376 "p-Y389,400-RUFY1 binds PI3P" is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005515 ! protein binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18655" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19409" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22925" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31444" xsd:anyURI [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0030881 name: beta-2-microglobulin binding namespace: molecular_function def: "Binding to beta-2-microglobulin." [GOC:mah] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, PMID:21123617, PMID:28089324, PMID:33605520] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031638 name: zymogen activation namespace: biological_process def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] subset: goslim_chembl synonym: "zymogen activation by proteolytic cleavage" EXACT [] is_a: GO:0016485 ! protein processing [Term] id: GO:0031639 name: plasminogen activation namespace: biological_process def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] subset: goslim_chembl synonym: "cleavage of plasminogen to plasmin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0031994 name: insulin-like growth factor I binding namespace: molecular_function def: "Binding to insulin-like growth factor I." [GOC:mah] subset: goslim_chembl synonym: "IGF-I binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031995 name: insulin-like growth factor II binding namespace: molecular_function def: "Binding to insulin-like growth factor II." [GOC:mah] subset: goslim_chembl synonym: "IGF-II binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0032182 name: ubiquitin-like protein binding namespace: molecular_function def: "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] subset: goslim_chembl subset: goslim_yeast synonym: "small conjugating protein binding" EXACT [GOC:dph] is_a: GO:0005515 ! protein binding [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site." [ISBN:1555812090, PMID:14682279, PMID:25893143] subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Transposon is_a: GO:0008150 ! biological_process [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: gocheck_obsoletion_candidate subset: goslim_chembl xref: Reactome:R-HSA-156581 "Methylation" xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27423" xsd:anyURI [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process alt_id: GO:1903827 def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0033961 name: cis-stilbene-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "cis-epoxide hydrolase activity" RELATED [EC:3.3.2.9] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "mEH" RELATED [EC:3.3.2.9] synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] xref: EC:3.3.2.9 xref: MetaCyc:3.3.2.9-RXN xref: Reactome:R-HSA-5694077 "EPHX1 hydrates BaP4,5O to BaP4,5-DHD" xref: RHEA:23900 is_a: GO:0004301 ! epoxide hydrolase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.3.2.9 property_value: exactMatch http://rdf.rhea-db.org/23900 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27074" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_chembl synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0009056 ! catabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31498" xsd:anyURI [Term] id: GO:0035254 name: glutamate receptor binding namespace: molecular_function def: "Binding to a glutamate receptor." [GOC:bf] subset: goslim_chembl is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0035634 name: response to stilbenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [GOC:yaf, Wikipedia:Stilbenoid] subset: goslim_chembl is_a: GO:0008150 ! biological_process created_by: bf creation_date: 2011-01-12T10:37:33Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process alt_id: GO:0006464 def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote synonym: "cellular protein modification process" EXACT [] synonym: "process resulting in protein modification" EXACT [] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI created_by: bf creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function alt_id: GO:0004872 alt_id: GO:0019041 def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] synonym: "signalling receptor activity" EXACT [] is_a: GO:0003674 ! molecular_function created_by: bf creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0042056 name: chemoattractant activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:curators, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "attractant" BROAD [] is_a: GO:0048018 ! receptor ligand activity relationship: part_of GO:0040011 ! locomotion [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0042393 name: histone binding namespace: molecular_function def: "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "histone-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23106" xsd:anyURI [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0042592 name: homeostatic process namespace: biological_process alt_id: GO:0032844 alt_id: GO:0032845 alt_id: GO:0032846 def: "Any biological process involved in the maintenance of an internal steady state. Homeostasis allows cells and organisms to maintain stable internal conditions despite varying external conditions." [PMID:26265027] subset: goslim_agr subset: goslim_chembl subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31175" xsd:anyURI [Term] id: GO:0042605 name: peptide antigen binding namespace: molecular_function alt_id: GO:0042606 alt_id: GO:0042607 def: "Binding to an antigen peptide." [GOC:add, GOC:jl, GOC:rv] comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule. subset: goslim_chembl synonym: "endogenous peptide antigen binding" NARROW [] synonym: "exogenous peptide antigen binding" NARROW [] is_a: GO:0003823 ! antigen binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0042802 name: identical protein binding namespace: molecular_function def: "Binding to an identical protein or proteins." [GOC:jl] subset: goslim_chembl synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655] synonym: "protein homopolymerization" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042803 name: protein homodimerization activity namespace: molecular_function def: "Binding to an identical protein to form a homodimer." [GOC:jl] subset: goslim_chembl synonym: "dimerization activity" BROAD [] is_a: GO:0042802 ! identical protein binding [Term] id: GO:0042813 name: Wnt receptor activity namespace: molecular_function def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:curators] subset: goslim_chembl synonym: "frizzled receptor activity" RELATED [] synonym: "frizzled-2 receptor activity" RELATED [] synonym: "Wnt-activated receptor activity" EXACT [] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0017147 ! Wnt-protein binding relationship: part_of GO:0007165 ! signal transduction property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23056" xsd:anyURI [Term] id: GO:0043008 name: ATP-dependent protein binding namespace: molecular_function def: "Binding to a protein or protein complex using energy from ATP hydrolysis." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] xref: Reactome:R-HSA-193648 "NRAGE signals death through JNK" xref: Reactome:R-HSA-205043 "NRIF signals cell death from the nucleus" is_a: GO:0008150 ! biological_process relationship: positively_regulates GO:0012501 ! programmed cell death relationship: regulates GO:0012501 ! programmed cell death [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0050790 ! regulation of catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: GO:0003674 ! molecular_function property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0005575 ! cellular_component [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0044179 name: hemolysis in another organism namespace: biological_process alt_id: GO:1990142 def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl, PMID:21590705] subset: goslim_chembl synonym: "envenomation resulting in hemolysis in another organism" NARROW [] synonym: "envenomation resulting in hemolysis in other organism" NARROW [] synonym: "hemolysis in other organism" EXACT [] synonym: "hemolysis of cells in other organism" EXACT [GOC:bf] synonym: "hemolysis of erythrocytes in other organism" EXACT [] synonym: "hemolysis of RBCs in other organism" EXACT [] synonym: "hemolysis of red blood cells in other organism" EXACT [] is_a: GO:0019835 ! cytolysis created_by: jl creation_date: 2009-09-04T03:36:00Z [Term] id: GO:0044183 name: protein folding chaperone namespace: molecular_function def: "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] comment: Note that a protein folding chaperone binds an unfolded protein to fold it. Do not confuse with unfolded protein holdase activity, which binds an unfolded protein and keeps it unfolded to deliver it to its final destination. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote synonym: "chaperone activity" BROAD [] synonym: "protein binding involved in protein folding" EXACT [] xref: Reactome:R-HSA-9018785 "RHOBTB2 binds GTP" xref: Reactome:R-HSA-9855212 "SDHA binds to SDHB" xref: Reactome:R-HSA-9865893 "MT-CYB is translated" xref: Reactome:R-HSA-9866253 "apo-UQCRFS1 binds LYRM7" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0006457 ! protein folding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30552" xsd:anyURI created_by: jl creation_date: 2009-09-25T11:33:48Z [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31485" xsd:anyURI created_by: jl creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044325 name: transmembrane transporter binding namespace: molecular_function def: "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] subset: goslim_chembl synonym: "ion channel binding" NARROW [] is_a: GO:0005515 ! protein binding property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21331" xsd:anyURI created_by: jl creation_date: 2010-08-04T12:52:59Z [Term] id: GO:0044403 name: biological process involved in symbiotic interaction namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129] subset: goslim_chembl synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] synonym: "symbiotic process" RELATED [] xref: Reactome:R-HSA-9839923 "Dengue Virus Infection" is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14807" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI [Term] id: GO:0044423 name: virion component namespace: cellular_component alt_id: GO:0019012 def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" RELATED [] synonym: "virion" RELATED [] synonym: "virion part" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function alt_id: GO:0032403 def: "Binding to a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: GO:0003674 ! molecular_function created_by: jl creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0045569 name: TRAIL binding namespace: molecular_function def: "Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:curators, PMID:9082980] subset: goslim_chembl synonym: "Apo-2L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0046677 name: response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] subset: goslim_chembl synonym: "antibiotic susceptibility/resistance" RELATED [] xref: Reactome:R-HSA-9638771 "Action of antimicrobials" xref: Reactome:R-HSA-9639775 "Antimicrobial action and antimicrobial resistance in Mtb" xref: Reactome:R-HSA-9913143 "Antimicrobial resistance" is_a: GO:0008150 ! biological_process [Term] id: GO:0046789 name: host cell surface receptor binding namespace: molecular_function def: "Binding to a receptor on the host cell surface." [GOC:ai, PMID:11511370] subset: goslim_chembl synonym: "cell surface antigen activity, host-interacting" RELATED [] synonym: "cell surface receptor ligand" RELATED [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0044403 ! biological process involved in symbiotic interaction [Term] id: GO:0046982 name: protein heterodimerization activity namespace: molecular_function def: "Binding to a nonidentical protein to form a heterodimer." [GOC:ai] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0047372 name: monoacylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+." [RHEA:15245] subset: goslim_chembl synonym: "acylglycerol lipase activity" BROAD [] synonym: "fatty acyl monoester lipase activity" RELATED [EC:3.1.1.23] synonym: "glycerol-ester acylhydrolase activity" RELATED [EC:3.1.1.23] synonym: "monoacylglycerol hydrolase activity" RELATED [EC:3.1.1.23] synonym: "monoacylglycerolipase activity" RELATED [EC:3.1.1.23] synonym: "monoglyceridase activity" RELATED [EC:3.1.1.23] synonym: "monoglyceride hydrolase activity" RELATED [EC:3.1.1.23] synonym: "monoglyceride lipase activity" RELATED [EC:3.1.1.23] synonym: "monoglyceridyllipase activity" RELATED [EC:3.1.1.23] xref: EC:3.1.1.23 xref: MetaCyc:RXN-19280 xref: Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL" xref: Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid" xref: Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase" xref: Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase" xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2" xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG" xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL" xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG" xref: RHEA:15245 xref: RHEA:26132 xref: RHEA:32875 xref: RHEA:34019 xref: RHEA:38363 xref: RHEA:38487 xref: RHEA:38491 xref: RHEA:39959 xref: RHEA:39963 xref: RHEA:40603 xref: RHEA:40607 xref: RHEA:44312 xref: RHEA:44316 xref: RHEA:44320 xref: RHEA:44328 xref: RHEA:44688 xref: RHEA:44728 xref: RHEA:44732 xref: RHEA:47072 xref: RHEA:48428 xref: RHEA:58040 xref: RHEA:58076 xref: RHEA:58080 xref: RHEA:58084 xref: RHEA:58088 xref: RHEA:58092 xref: RHEA:58096 xref: RHEA:58100 xref: RHEA:78151 is_a: GO:0016298 ! lipase activity property_value: broadMatch http://purl.uniprot.org/enzyme/3.1.1.79 property_value: exactMatch http://identifiers.org/metacyc.reaction/RXN-19280 property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.1.23 property_value: exactMatch http://rdf.rhea-db.org/15245 property_value: narrowMatch http://rdf.rhea-db.org/26132 property_value: narrowMatch http://rdf.rhea-db.org/32875 property_value: narrowMatch http://rdf.rhea-db.org/34019 property_value: narrowMatch http://rdf.rhea-db.org/38363 property_value: narrowMatch http://rdf.rhea-db.org/38487 property_value: narrowMatch http://rdf.rhea-db.org/38491 property_value: narrowMatch http://rdf.rhea-db.org/39959 property_value: narrowMatch http://rdf.rhea-db.org/39963 property_value: narrowMatch http://rdf.rhea-db.org/40603 property_value: narrowMatch http://rdf.rhea-db.org/40607 property_value: narrowMatch http://rdf.rhea-db.org/44312 property_value: narrowMatch http://rdf.rhea-db.org/44316 property_value: narrowMatch http://rdf.rhea-db.org/44320 property_value: narrowMatch http://rdf.rhea-db.org/44328 property_value: narrowMatch http://rdf.rhea-db.org/44688 property_value: narrowMatch http://rdf.rhea-db.org/44728 property_value: narrowMatch http://rdf.rhea-db.org/44732 property_value: narrowMatch http://rdf.rhea-db.org/47072 property_value: narrowMatch http://rdf.rhea-db.org/48428 property_value: narrowMatch http://rdf.rhea-db.org/58040 property_value: narrowMatch http://rdf.rhea-db.org/58076 property_value: narrowMatch http://rdf.rhea-db.org/58080 property_value: narrowMatch http://rdf.rhea-db.org/58084 property_value: narrowMatch http://rdf.rhea-db.org/58088 property_value: narrowMatch http://rdf.rhea-db.org/58092 property_value: narrowMatch http://rdf.rhea-db.org/58096 property_value: narrowMatch http://rdf.rhea-db.org/58100 property_value: narrowMatch http://rdf.rhea-db.org/78151 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28339" xsd:anyURI [Term] id: GO:0047617 name: fatty acyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0008778 alt_id: GO:0016291 alt_id: GO:0016292 def: "Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781] subset: goslim_chembl synonym: "acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.20] synonym: "acyl coenzyme A thioesterase activity" RELATED [EC:3.1.2.20] synonym: "acyl-CoA hydrolase activity" BROAD [] synonym: "acyl-CoA thioesterase activity" EXACT [] synonym: "acyl-CoA thioesterase I activity" NARROW [] synonym: "acyl-CoA thioesterase II activity" NARROW [] synonym: "acyl-CoA thiolesterase activity" EXACT [] synonym: "thioesterase B" RELATED [EC:3.1.2.20] synonym: "thioesterase II" RELATED [EC:3.1.2.20] xref: EC:3.1.2.20 xref: MetaCyc:ACYL-COA-HYDROLASE-RXN xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA" xref: Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA" xref: Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA" xref: RHEA:16781 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.2.20 property_value: exactMatch http://rdf.rhea-db.org/16781 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26441" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0047704 name: bile-salt sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" RELATED [EC:2.8.2.14] synonym: "BAST I activity" NARROW [EC:2.8.2.14] synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" RELATED [EC:2.8.2.14] synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" RELATED [EC:2.8.2.14] synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN xref: RHEA:14013 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.14 property_value: exactMatch http://rdf.rhea-db.org/14013 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0047894 name: flavonol 3-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13453] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25] synonym: "flavonol 3-sulphotransferase activity" EXACT [] xref: EC:2.8.2.25 xref: KEGG_REACTION:R02159 xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN xref: RHEA:13453 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.25 property_value: exactMatch http://rdf.rhea-db.org/13453 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0048018 name: receptor ligand activity namespace: molecular_function alt_id: GO:0071884 def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "agonist" BROAD [] synonym: "receptor agonist activity" RELATED [GOC:molecular_function_refactoring] synonym: "signaling molecule" BROAD [] synonym: "signaling receptor ligand activity" EXACT [] xref: Reactome:R-HSA-381612 "GLP1R binds GLP1" xref: Reactome:R-HSA-8848663 "ADIPOQ trimer binds ADIPOR dimers" is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005102 ! signaling receptor binding relationship: part_of GO:0007165 ! signal transduction relationship: positively_regulates GO:0038023 ! signaling receptor activity relationship: regulates GO:0038023 ! signaling receptor activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14220" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27076" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31015" xsd:anyURI created_by: mah creation_date: 2010-09-13T04:51:59Z [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0008150 ! biological_process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_plant_ribbon synonym: "development of an anatomical structure" EXACT [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_prokaryote synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0050294 name: steroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" RELATED [EC:2.8.2.15] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] synonym: "steroid sulphotransferase activity" EXACT [] xref: EC:2.8.2.15 xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176517 "SULTs transfer (SO4)2- group to PREG" xref: Reactome:R-HSA-176521 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP" xref: Reactome:R-HSA-176631 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP" xref: RHEA:52372 xref: RHEA:68460 is_a: GO:0008146 ! sulfotransferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.8.2.15 property_value: exactMatch http://rdf.rhea-db.org/68460 property_value: narrowMatch http://rdf.rhea-db.org/52372 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21412" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0008150 ! biological_process relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050821 name: protein stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] subset: goslim_chembl synonym: "lysosomal protein stabilization" NARROW [] synonym: "positive regulation of protein stability" EXACT [] synonym: "protein sequestering" RELATED [] synonym: "protein stabilisation" EXACT [GOC:ah] synonym: "protein stabilization activity" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Binding to a component of the extracellular matrix." [GOC:ai] subset: goslim_chembl subset: goslim_pir synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/13824" xsd:anyURI [Term] id: GO:0051219 name: phosphoprotein binding namespace: molecular_function def: "Binding to a phosphorylated protein." [GOC:ai] subset: goslim_chembl synonym: "phosphorylated protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0006323 alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "DNA condensation" EXACT [] synonym: "DNA packaging" NARROW [] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22811" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/4585" xsd:anyURI [Term] id: GO:0051287 name: NAD binding namespace: molecular_function alt_id: GO:0051288 def: "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] subset: goslim_chembl synonym: "NAD or NADH binding" RELATED [GOC:mah] synonym: "NAD+ or NADH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] is_a: GO:0030554 ! adenyl nucleotide binding [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:curators, GOC:di, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0008150 ! biological_process [Term] id: GO:0051400 name: BH domain binding namespace: molecular_function def: "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] subset: goslim_chembl synonym: "Bcl-2 homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051428 name: peptide hormone receptor binding namespace: molecular_function def: "Binding to a receptor for a peptide hormone." [GOC:ai] subset: goslim_chembl synonym: "polypeptide hormone receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0051434 name: BH3 domain binding namespace: molecular_function def: "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] subset: goslim_chembl is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast xref: Reactome:R-HSA-9918432 "Maturation of DENV proteins" is_a: GO:0008152 ! metabolic process relationship: part_of GO:0009058 ! biosynthetic process [Term] id: GO:0051992 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP." [RHEA:28386] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl xref: MetaCyc:PHOSNACMURPENTATRANS-RXN xref: RHEA:28386 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: broadMatch http://purl.uniprot.org/enzyme/2.7.8.13 property_value: exactMatch http://rdf.rhea-db.org/28386 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI created_by: ai creation_date: 2010-07-06T12:10:01Z [Term] id: GO:0052654 name: L-leucine:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction:L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [RHEA:18321] subset: goslim_chembl synonym: "L-leucine aminotransferase activity" EXACT [] synonym: "L-leucine-2-oxoglutarate transaminase activity" EXACT [] xref: EC:2.6.1.6 xref: KEGG_REACTION:R01090 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN xref: RHEA:18321 is_a: GO:0016740 ! transferase activity property_value: exactMatch http://purl.uniprot.org/enzyme/2.6.1.6 property_value: exactMatch http://rdf.rhea-db.org/18321 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28176" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31140" xsd:anyURI [Term] id: GO:0052655 name: L-valine:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate." [RHEA:24813] subset: goslim_chembl synonym: "L-valine aminotransferase activity" EXACT [] synonym: "L-valine-2-oxoglutarate transaminase activity" EXACT [] xref: KEGG_REACTION:R01214 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN xref: RHEA:24813 is_a: GO:0016740 ! transferase activity property_value: exactMatch http://rdf.rhea-db.org/24813 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/31140" xsd:anyURI [Term] id: GO:0052656 name: L-isoleucine:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate." [RHEA:24801] subset: goslim_chembl synonym: "L-isoleucine aminotransferase activity" EXACT [] synonym: "L-isoleucine-2-oxoglutarate transaminase activity" EXACT [] xref: KEGG_REACTION:R02199 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN xref: RHEA:24801 is_a: GO:0016740 ! transferase activity property_value: exactMatch http://rdf.rhea-db.org/24801 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28070" xsd:anyURI [Term] id: GO:0055036 name: virion membrane namespace: cellular_component def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106] subset: goslim_chembl is_a: GO:0044423 ! virion component [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process alt_id: GO:0090662 def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] xref: Reactome:R-HSA-382556 "ABC-family proteins mediated transport" xref: Reactome:R-HSA-425407 "SLC-mediated transmembrane transport" xref: Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" is_a: GO:0006810 ! transport created_by: tb creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] xref: Reactome:R-HSA-199991 "Membrane Trafficking" is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 alt_id: GO:0034622 alt_id: GO:0043623 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI [Term] id: GO:0070290 name: N-acylphosphatidylethanolamine-specific phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+." [PMID:14634025, PMID:15878693, RHEA:33159] subset: goslim_chembl synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT [] synonym: "NAPE-specific phospholipase D activity" EXACT [] xref: EC:3.1.4.54 xref: MetaCyc:RXN-12116 xref: Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E" xref: RHEA:33159 xref: RHEA:45528 xref: RHEA:45532 xref: RHEA:45536 xref: RHEA:45540 xref: RHEA:45552 xref: RHEA:45556 xref: RHEA:45596 xref: RHEA:45608 xref: RHEA:45612 xref: RHEA:45616 xref: RHEA:45620 xref: RHEA:56544 xref: RHEA:56548 is_a: GO:0004630 ! D-type glycerophospholipase activity property_value: exactMatch http://purl.uniprot.org/enzyme/3.1.4.54 property_value: exactMatch http://rdf.rhea-db.org/33159 property_value: narrowMatch http://rdf.rhea-db.org/45528 property_value: narrowMatch http://rdf.rhea-db.org/45532 property_value: narrowMatch http://rdf.rhea-db.org/45536 property_value: narrowMatch http://rdf.rhea-db.org/45540 property_value: narrowMatch http://rdf.rhea-db.org/45552 property_value: narrowMatch http://rdf.rhea-db.org/45556 property_value: narrowMatch http://rdf.rhea-db.org/45596 property_value: narrowMatch http://rdf.rhea-db.org/45608 property_value: narrowMatch http://rdf.rhea-db.org/45612 property_value: narrowMatch http://rdf.rhea-db.org/45616 property_value: narrowMatch http://rdf.rhea-db.org/45620 property_value: narrowMatch http://rdf.rhea-db.org/56544 property_value: narrowMatch http://rdf.rhea-db.org/56548 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27559" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/30193" xsd:anyURI [Term] id: GO:0070324 name: thyroid hormone binding namespace: molecular_function def: "Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph] subset: goslim_chembl synonym: "thyroxine binding" NARROW [GOC:mah] synonym: "triiodothyronine binding" NARROW [GOC:mah] is_a: GO:0042562 ! hormone binding [Term] id: GO:0070628 name: proteasome binding namespace: molecular_function def: "Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] subset: goslim_chembl is_a: GO:0044877 ! protein-containing complex binding created_by: mah creation_date: 2009-05-01T04:38:58Z [Term] id: GO:0070976 name: TIR domain binding namespace: molecular_function def: "Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] subset: goslim_chembl synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157] is_a: GO:0019904 ! protein domain specific binding created_by: mah creation_date: 2009-10-02T01:17:29Z [Term] id: GO:0070989 name: oxidative demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] subset: goslim_chembl is_a: GO:0008152 ! metabolic process created_by: mah creation_date: 2009-10-29T03:33:25Z [Term] id: GO:0071466 name: cellular response to xenobiotic stimulus namespace: biological_process alt_id: GO:0035690 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:krc, GOC:mah] subset: goslim_chembl synonym: "cellular response to drug" RELATED [] is_a: GO:0008150 ! biological_process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19460" xsd:anyURI created_by: mah creation_date: 2009-12-18T11:38:48Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0008150 ! biological_process created_by: mah creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071941 name: nitrogen cycle metabolic process namespace: biological_process def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote xref: Wikipedia:Nitrogen_cycle is_a: GO:0008152 ! metabolic process created_by: mah creation_date: 2010-09-30T05:21:03Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0000278 ! mitotic cell cycle property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI created_by: pg creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140657 name: ATP-dependent activity namespace: molecular_function def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "ATP hydrolysis-dependent activity" EXACT [] synonym: "ATPase activity" EXACT [] synonym: "ATPase activity, coupled" EXACT [] synonym: "ATPase-dependent activity" EXACT [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0017111 ! ribonucleoside triphosphate phosphatase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI created_by: pg creation_date: 2021-06-15T07:35:06Z [Typedef] id: ends_during name: ends during namespace: external xref: RO:0002093 [Typedef] id: happens_during name: happens during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends during [Typedef] id: has_ontology_root_term name: has ontology root term namespace: external xref: IAO:0000700 is_metadata_tag: true is_class_level: true [Typedef] id: has_part name: has part namespace: external xref: BFO:0000051 is_transitive: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 is_a: regulates ! regulates [Typedef] id: occurs_in name: occurs in namespace: external xref: BFO:0000066 transitive_over: part_of ! part of [Typedef] id: part_of name: part of namespace: external xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has part [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 holds_over_chain: negatively_regulates negatively_regulates is_a: regulates ! regulates [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 is_transitive: true [Typedef] id: starts_during name: starts during namespace: external xref: RO:0002091 [Typedef] id: term_tracker_item name: term tracker item namespace: external xref: IAO:0000233 is_metadata_tag: true is_class_level: true