goslim prokaryote.owl
type: Ontology
version IRI: goslim prokaryote.owl
version info: 2024-10-21

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

cytokinesis
type: Class
subclass of: Restriction
  on property: has part
  some values from: membrane organization
definition: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Wikipedia:Cytokinesis
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
has_obo_namespace: biological_process
id: GO:0000910
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.

Axiom
annotated source: cytokinesis
annotated property: definition
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
database_cross_reference: GOC:mtg_cell_cycle

Axiom
annotated source: cytokinesis
annotated property: has_exact_synonym
annotated target: cytokinesis involved in cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

DNA binding
type: Class
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

RNA binding
type: Class
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

cytoskeletal motor activity
type: Class
definition: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
term tracker item: https://github.com/geneontology/go-ontology/issues/19590
term tracker item: https://github.com/geneontology/go-ontology/issues/21756
has_broad_synonym: motor activity
database_cross_reference: Reactome:R-HSA-1861595
has_obo_namespace: molecular_function
id: GO:0003774
in_subset: goslim candida
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: cytoskeletal motor activity
annotated property: definition
annotated target: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:11242086
database_cross_reference: PMID:29716949

Extension of pseudopodia by myosin-X in a PI3K dependent manner
type: Axiom
annotated source: cytoskeletal motor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1861595

GTPase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
term tracker item: https://github.com/geneontology/go-ontology/issues/26014
created by: dph
creation date: 2015-11-11T12:47:56Z
has_alternative_id: GO:0061745
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
database_cross_reference: MetaCyc:RXN0-5462
database_cross_reference: RHEA:19669
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9018814
database_cross_reference: Reactome:R-HSA-9018826
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
has_narrow_synonym: ARF small monomeric GTPase activity
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation
has_narrow_synonym: protein-synthesizing GTPase activity, initiation
has_narrow_synonym: protein-synthesizing GTPase activity, termination
has_narrow_synonym: signal-recognition-particle GTPase activity

Axiom
annotated source: GTPase activity
annotated property: definition
annotated target: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
database_cross_reference: PMID:26832457
database_cross_reference: PMID:27218782

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983422

structural molecule activity
type: Class
definition: The action of a molecule that contributes to the structural integrity of a complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/24130
has_obo_namespace: molecular_function
id: GO:0005198
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: structural molecule activity
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a complex.
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

transporter activity
type: Class
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
term tracker item: https://github.com/geneontology/go-ontology/issues/27621
has_alternative_id: GO:0005478
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

extracellular region
type: Class
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:go_curators

cell wall
type: Class
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/21669
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

chromosome
type: Class
subclass of: organelle
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: Wikipedia:Chromosome
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
id: GO:0005694
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684

cytoplasm
type: Class
definition: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
term tracker item: https://github.com/geneontology/go-ontology/issues/23023
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
id: GO:0005737
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cytoplasm
annotated property: definition
annotated target: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684

ribosome
type: Class
subclass of: organelle
definition: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
has_alternative_id: GO:0033279
database_cross_reference: NIF_Subcellular:sao1429207766
database_cross_reference: Wikipedia:Ribosome
has_narrow_synonym: free ribosome
has_narrow_synonym: membrane bound ribosome
has_obo_namespace: cellular_component
has_related_synonym: ribosomal RNA
id: GO:0005840
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: ribosome
annotated property: definition
annotated target: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: free ribosome
database_cross_reference: NIF_Subcellular:sao1139385046

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: membrane bound ribosome
database_cross_reference: NIF_Subcellular:sao1291545653

cytoskeleton
type: Class
subclass of: organelle
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

carbohydrate metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
term tracker item: https://github.com/geneontology/go-ontology/issues/22880
created by: jl
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

generation of precursor metabolites and energy
type: Class
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
has_broad_synonym: energy pathways
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
has_related_synonym: metabolic energy generation
id: GO:0006091
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
database_cross_reference: GOC:jl

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

DNA replication
type: Class
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/10596
has_alternative_id: GO:0055133
database_cross_reference: Wikipedia:DNA_replication
has_obo_namespace: biological_process
id: GO:0006260
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.

Axiom
annotated source: DNA replication
annotated property: definition
annotated target: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
database_cross_reference: GOC:mah

DNA repair
type: Class
subclass of: response to stimulus
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
id: GO:0006281
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA repair
annotated property: definition
annotated target: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: PMID:11563486

DNA recombination
type: Class
definition: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
has_obo_namespace: biological_process
id: GO:0006310
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA recombination
annotated property: definition
annotated target: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
database_cross_reference: ISBN:0198506732

DNA-templated transcription
type: Class
subclass of: RNA metabolic process
definition: The synthesis of an RNA transcript from a DNA template.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
term tracker item: https://github.com/geneontology/go-ontology/issues/16737
term tracker item: https://github.com/geneontology/go-ontology/issues/22258
term tracker item: https://github.com/geneontology/go-ontology/issues/22555
has_alternative_id: GO:0001121
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database_cross_reference: Wikipedia:Transcription_(genetics)
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: transcription, DNA-dependent
has_exact_synonym: transcription, DNA-templated
has_narrow_synonym: bacterial transcription
has_narrow_synonym: transcription from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
id: GO:0006351
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: DNA-templated transcription
annotated property: definition
annotated target: The synthesis of an RNA transcript from a DNA template.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription
annotated property: has_exact_synonym
annotated target: transcription, DNA-dependent
database_cross_reference: GOC:txnOH

regulation of DNA-templated transcription
type: Class
subclass of: Restriction
  on property: regulates
  some values from: DNA-templated transcription
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/25256
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_broad_synonym: transcriptional control
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-templated
has_obo_namespace: biological_process
has_related_synonym: regulation of gene-specific transcription
id: GO:0006355
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: has_exact_synonym
annotated target: regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

translation
type: Class
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
database_cross_reference: Wikipedia:Translation_(genetics)
has_exact_synonym: protein anabolism
has_exact_synonym: protein biosynthesis
has_exact_synonym: protein biosynthetic process
has_exact_synonym: protein formation
has_exact_synonym: protein synthesis
has_exact_synonym: protein translation
has_obo_namespace: biological_process
id: GO:0006412
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation
annotated property: definition
annotated target: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: GOC:go_curators

protein folding
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein maturation
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
term tracker item: https://github.com/geneontology/go-ontology/issues/25673
has_alternative_id: GO:0007022
has_alternative_id: GO:0007024
has_alternative_id: GO:0007025
database_cross_reference: Wikipedia:Protein_folding
has_narrow_synonym: alpha-tubulin folding
has_narrow_synonym: beta-tubulin folding
has_narrow_synonym: chaperonin-mediated tubulin folding
has_obo_namespace: biological_process
has_related_synonym: chaperone activity
has_related_synonym: chaperonin ATPase activity
has_related_synonym: co-chaperone activity
has_related_synonym: co-chaperonin activity
has_related_synonym: glycoprotein-specific chaperone activity
has_related_synonym: non-chaperonin molecular chaperone ATPase activity
has_related_synonym: protein complex assembly, multichaperone pathway
id: GO:0006457
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: protein folding
annotated property: definition
annotated target: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:rb

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: alpha-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: beta-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: chaperonin-mediated tubulin folding
database_cross_reference: GOC:mah

protein glycosylation
type: Class
subclass of: protein modification process
subclass of: Restriction
  on property: part of
  some values from: carbohydrate derivative metabolic process
definition: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
has_alternative_id: GO:0065006
has_exact_synonym: protein amino acid glycosylation
has_obo_namespace: biological_process
has_related_synonym: protein-carbohydrate complex assembly
id: GO:0006486
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein glycosylation
annotated property: definition
annotated target: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pr

Axiom
annotated source: protein glycosylation
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation
database_cross_reference: GOC:bf

amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
term tracker item: https://github.com/geneontology/go-ontology/issues/17904
has_alternative_id: GO:0006519
has_exact_synonym: cellular amino acid metabolic process
has_exact_synonym: cellular amino acid metabolism
has_obo_namespace: biological_process
has_related_synonym: amino acid and derivative metabolism
has_related_synonym: cellular amino acid and derivative metabolic process
id: GO:0006520
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
database_cross_reference: ISBN:0198506732

modified amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
term tracker item: https://github.com/geneontology/go-ontology/issues/28908
has_exact_synonym: amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolism
has_exact_synonym: cellular modified amino acid metabolic process
has_exact_synonym: cellular modified amino acid metabolism
has_exact_synonym: modified amino acid metabolism
has_obo_namespace: biological_process
id: GO:0006575
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: modified amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
database_cross_reference: GOC:ai

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolic process
database_cross_reference: GOC:mah

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolism
database_cross_reference: GOC:mah

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolism
database_cross_reference: GOC:mah

lipid metabolic process
type: Class
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

sulfur compound metabolic process
type: Class
definition: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: Wikipedia:Sulfur_metabolism
has_exact_synonym: sulfur metabolism
has_exact_synonym: sulphur metabolic process
has_exact_synonym: sulphur metabolism
has_obo_namespace: biological_process
id: GO:0006790
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: sulfur compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: GOC:ai

transport
type: Class
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/20292
created by: jl
creation date: 2012-12-13T16:25:32Z
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
has_alternative_id: GO:0044765
has_obo_namespace: biological_process
has_related_synonym: single-organism transport
id: GO:0006810
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.

Axiom
annotated source: transport
annotated property: definition
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
database_cross_reference: GOC:dos
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

intracellular protein transport
type: Class
subclass of: transport
definition: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
has_alternative_id: GO:0032779
has_obo_namespace: biological_process
has_related_synonym: copper-induced intracellular protein transport
id: GO:0006886
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: intracellular protein transport
annotated property: definition
annotated target: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein transport
annotated property: has_related_synonym
annotated target: copper-induced intracellular protein transport
database_cross_reference: GOC:al

cytoskeleton organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

chromosome segregation
type: Class
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

cell adhesion
type: Class
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
created by: dos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion
annotated property: definition
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf

establishment or maintenance of cell polarity
type: Class
definition: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
has_alternative_id: GO:0030012
has_alternative_id: GO:0030467
has_obo_namespace: biological_process
has_related_synonym: cell polarity
has_related_synonym: establishment and/or maintenance of cell polarity
has_related_synonym: establishment and/or maintenance of cell polarization
id: GO:0007163
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: definition
annotated target: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
database_cross_reference: GOC:mah

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: has_related_synonym
annotated target: cell polarity
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

cytoskeletal protein binding
type: Class
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

lipid binding
type: Class
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

cell outer membrane
type: Class
definition: A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
has_exact_synonym: outer membrane of cell
has_obo_namespace: cellular_component
id: GO:0009279
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886.

Axiom
annotated source: cell outer membrane
annotated property: definition
annotated target: A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
database_cross_reference: GOC:md
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0135712254

thylakoid
type: Class
subclass of: organelle
definition: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
term tracker item: https://github.com/geneontology/go-ontology/issues/13958
database_cross_reference: Wikipedia:Thylakoid
has_obo_namespace: cellular_component
has_related_synonym: photosynthetic membrane
id: GO:0009579
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.

Axiom
annotated source: thylakoid
annotated property: definition
annotated target: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
database_cross_reference: GOC:ds
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

cyclase activity
type: Class
definition: Catalysis of a ring closure reaction.
has_obo_namespace: molecular_function
id: GO:0009975
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: cyclase activity
annotated property: definition
annotated target: Catalysis of a ring closure reaction.
database_cross_reference: ISBN:0198547684

programmed cell death
type: Class
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24835
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

photosynthesis
type: Class
definition: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
database_cross_reference: Wikipedia:Photosynthesis
has_obo_namespace: biological_process
id: GO:0015979
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: photosynthesis
annotated property: definition
annotated target: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
database_cross_reference: ISBN:0198547684

RNA metabolic process
type: Class
definition: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
has_exact_synonym: RNA metabolism
has_obo_namespace: biological_process
id: GO:0016070
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: RNA metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
database_cross_reference: ISBN:0198506732

mRNA metabolic process
type: Class
subclass of: RNA metabolic process
definition: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
has_exact_synonym: mRNA metabolism
has_obo_namespace: biological_process
id: GO:0016071
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: mRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
database_cross_reference: ISBN:0198506732

antioxidant activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: detoxification
definition: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
has_obo_namespace: molecular_function
id: GO:0016209
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: antioxidant activity
annotated property: definition
annotated target: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
database_cross_reference: ISBN:0198506732

oxidoreductase activity
type: Class
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-209921
database_cross_reference: Reactome:R-HSA-209960
database_cross_reference: Reactome:R-HSA-3095889
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-5662660
database_cross_reference: Reactome:R-HSA-8878581
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

Monoiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209921

Diiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209960

MMACHC dealkylates RCbl
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3095889

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

Dopachrome is transformed to DHICA by DCT
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5662660

TYRP1 oxidises DHICA to IQCA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8878581

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

transferase activity
type: Class
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

hydrolase activity
type: Class
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

lyase activity
type: Class
definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-
database_cross_reference: Reactome:R-HSA-5696408
database_cross_reference: Reactome:R-HSA-6782895
has_obo_namespace: molecular_function
id: GO:0016829
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lyase activity
annotated property: definition
annotated target: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5696408

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782895

isomerase activity
type: Class
definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: EC:5.-.-.-
database_cross_reference: Reactome:R-HSA-6787623
has_narrow_synonym: other isomerase activity
has_obo_namespace: molecular_function
id: GO:0016853
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: isomerase activity
annotated property: definition
annotated target: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: ISBN:0198506732

TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787623

ligase activity
type: Class
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: EC:6.-.-.-

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

signaling
type: Class
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
created by: jl
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has_exact_synonym: biological signaling
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in_subset: goslim agr
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

Axiom
annotated source: signaling
annotated property: definition
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling
annotated property: has_related_synonym
annotated target: signalling process
database_cross_reference: GOC:mah

cell projection organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
term tracker item: https://github.com/geneontology/go-ontology/issues/26279
has_exact_synonym: cell projection organisation
has_obo_namespace: biological_process
has_related_synonym: cell projection organization and biogenesis
has_related_synonym: cell surface structure organization and biogenesis
id: GO:0030030
in_subset: goslim prokaryote

Axiom
annotated source: cell projection organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: PMID:16318917

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell projection organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell surface structure organization and biogenesis
database_cross_reference: GOC:mah

protein catabolic process
type: Class
definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0044254
has_alternative_id: GO:0044257
database_cross_reference: Wikipedia:Protein_catabolism
has_exact_synonym: cellular protein breakdown
has_exact_synonym: cellular protein catabolic process
has_exact_synonym: cellular protein catabolism
has_exact_synonym: cellular protein degradation
has_exact_synonym: protein breakdown
has_exact_synonym: protein catabolism
has_exact_synonym: protein degradation
has_narrow_synonym: multicellular organismal protein catabolic process
has_obo_namespace: biological_process
has_related_synonym: pheromone catabolic process
has_related_synonym: pheromone catabolism
id: GO:0030163
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.

Axiom
annotated source: protein catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
database_cross_reference: GOC:mah

extracellular matrix
type: Class
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
has_alternative_id: GO:0005578
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: Wikipedia:Extracellular_matrix
has_exact_synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: extracellular matrix
annotated property: definition
annotated target: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rph
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: PMID:21123617
database_cross_reference: PMID:28089324

protein tag activity
type: Class
definition: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
has_broad_synonym: covalent modifier
has_exact_synonym: protein tag
has_exact_synonym: ubiquitin-like protein modifier
has_obo_namespace: molecular_function
has_related_synonym: protein tagging activity
has_related_synonym: ubiquitin
id: GO:0031386
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.

Axiom
annotated source: protein tag activity
annotated property: definition
annotated target: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19028679
database_cross_reference: PMID:20054389
database_cross_reference: PMID:6305978

Axiom
annotated source: protein tag activity
annotated property: has_broad_synonym
annotated target: covalent modifier
database_cross_reference: GOC:vw

tetrapyrrole metabolic process
type: Class
definition: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
has_exact_synonym: tetrapyrrole metabolism
has_obo_namespace: biological_process
id: GO:0033013
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: tetrapyrrole metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
database_cross_reference: GOC:mah

protein modification process
type: Class
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
created by: bf
creation date: 2012-04-26T01:47:12Z
has_alternative_id: GO:0006464
has_exact_synonym: cellular protein modification process
has_exact_synonym: process resulting in protein modification
has_exact_synonym: protein modification
has_obo_namespace: biological_process
id: GO:0036211
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote

Axiom
annotated source: protein modification process
annotated property: definition
annotated target: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

Axiom
annotated source: protein modification process
annotated property: has_exact_synonym
annotated target: protein modification
database_cross_reference: GOC:bf

bacterial nucleoid packaging
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: bacterial nucleoid
definition: A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling.
created by: bf
creation date: 2013-05-30T10:41:08Z
has_broad_synonym: chromosomal compaction
has_broad_synonym: nucleoid compaction
has_broad_synonym: prokaryotic DNA condensation
has_exact_synonym: bacterial nucleoid DNA packaging
has_obo_namespace: biological_process
id: GO:0036386
in_subset: goslim prokaryote

Axiom
annotated source: bacterial nucleoid packaging
annotated property: definition
annotated target: A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling.
database_cross_reference: GOC:bf
database_cross_reference: GOC:bhm
database_cross_reference: PMID:17097674
database_cross_reference: PMID:17360520

Axiom
annotated source: bacterial nucleoid packaging
annotated property: has_broad_synonym
annotated target: chromosomal compaction
database_cross_reference: PMID:17097674

Axiom
annotated source: bacterial nucleoid packaging
annotated property: has_broad_synonym
annotated target: nucleoid compaction
database_cross_reference: PMID:17097674

Axiom
annotated source: bacterial nucleoid packaging
annotated property: has_broad_synonym
annotated target: prokaryotic DNA condensation
database_cross_reference: Wikipedia:DNA_condensation

sRNA-mediated post-transcriptional gene silencing
type: Class
definition: A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria.
term tracker item: https://github.com/geneontology/go-ontology/issues/22860
term tracker item: https://github.com/geneontology/go-ontology/issues/22863
has_broad_synonym: RNA-mediated gene silencing by inhibition of translation
has_broad_synonym: downregulation of mRNA translation, ncRNA-mediated
has_broad_synonym: inhibition of mRNA translation, ncRNA-mediated
has_broad_synonym: sRNA-mediated gene silencing
has_exact_synonym: small RNA-mediated gene silencing
has_obo_namespace: biological_process
id: GO:0040033
in_subset: goslim prokaryote
comment: It is postulated that there 3 mechanisms of sRNA-mediated gene silencing: (i) translation inhibition, (ii) RNA destabilization, and (iii) transcription termination loop formation (as this is common when looking at riboswitches). sRNA mediated gene silencing is sometimes referred to as 'regulation of riboswitch'.

Axiom
annotated source: sRNA-mediated post-transcriptional gene silencing
annotated property: definition
annotated target: A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria.
database_cross_reference: PMID:12460531
database_cross_reference: PMID:2468565
database_cross_reference: PMID:33963446

xenobiotic catabolic process
type: Class
subclass of: Restriction
  on property: part of
  some values from: response to stimulus
definition: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organism exposed to it, carried out by individual cells. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
term tracker item: https://github.com/geneontology/go-ontology/issues/19460
term tracker item: https://github.com/geneontology/go-ontology/issues/28908
has_alternative_id: GO:0042737
has_alternative_id: GO:0042738
has_exact_synonym: xenobiotic breakdown
has_exact_synonym: xenobiotic catabolism
has_exact_synonym: xenobiotic degradation
has_obo_namespace: biological_process
has_related_synonym: drug breakdown
has_related_synonym: drug catabolic process
has_related_synonym: drug catabolism
has_related_synonym: drug degradation
has_related_synonym: exogenous drug breakdown
has_related_synonym: exogenous drug catabolic process
has_related_synonym: exogenous drug catabolism
has_related_synonym: exogenous drug degradation
id: GO:0042178
in_subset: goslim prokaryote

Axiom
annotated source: xenobiotic catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organism exposed to it, carried out by individual cells. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
database_cross_reference: GOC:jl
database_cross_reference: GOC:krc

ribosome biogenesis
type: Class
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
has_alternative_id: GO:0007046
has_exact_synonym: ribosome biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042254
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: ribosome biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:ma
database_cross_reference: PMID:26404467
database_cross_reference: Wikipedia:Ribosome_biogenesis

histone binding
type: Class
definition: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/23106
has_obo_namespace: molecular_function
has_related_synonym: histone-specific chaperone activity
id: GO:0042393
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: histone binding
annotated property: definition
annotated target: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16209651
database_cross_reference: PMID:30212449
database_cross_reference: PMID:9305837

periplasmic space
type: Class
definition: The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
has_alternative_id: GO:0005620
has_exact_synonym: periplasm
has_obo_namespace: cellular_component
id: GO:0042597
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: periplasmic space
annotated property: definition
annotated target: The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:md

cell projection
type: Class
definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
has_broad_synonym: cell process
has_broad_synonym: cellular process
has_exact_synonym: cellular projection
has_obo_namespace: cellular_component
id: GO:0042995
in_subset: goslim agr
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: cell projection
annotated property: definition
annotated target: A prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16318917

extracellular structure organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
has_exact_synonym: extracellular structure organisation
has_exact_synonym: extracellular structure organization and biogenesis
has_obo_namespace: biological_process
id: GO:0043062
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: extracellular structure organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: extracellular structure organization
annotated property: has_exact_synonym
annotated target: extracellular structure organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

organelle
type: Class
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao1539965131
database_cross_reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
id: GO:0043226
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

bacterial nucleoid
type: Class
subclass of: organelle
definition: The region of a bacterial cell to which the DNA is confined.
has_obo_namespace: cellular_component
id: GO:0043590
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: bacterial nucleoid
annotated property: definition
annotated target: The region of a bacterial cell to which the DNA is confined.
database_cross_reference: GOC:jl

protein folding chaperone
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein folding
definition: Binding to a protein or a protein-containing complex to assist the protein folding process.
created by: jl
creation date: 2009-09-25T11:33:48Z
has_broad_synonym: chaperone activity
database_cross_reference: Reactome:R-HSA-9018785
has_exact_synonym: protein binding involved in protein folding
has_obo_namespace: molecular_function
id: GO:0044183
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: protein folding chaperone
annotated property: definition
annotated target: Binding to a protein or a protein-containing complex to assist the protein folding process.
database_cross_reference: GOC:mtg_cambridge_2009

RHOBTB2 binds GTP
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018785

small molecule biosynthetic process
type: Class
definition: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
created by: jl
creation date: 2010-01-26T12:06:49Z
has_exact_synonym: small molecule biosynthesis
has_obo_namespace: biological_process
id: GO:0044283
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

secondary metabolite biosynthetic process
type: Class
definition: The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
created by: jl
creation date: 2012-03-29T01:55:18Z
has_exact_synonym: secondary metabolite biosynthesis
has_obo_namespace: biological_process
id: GO:0044550
in_subset: goslim prokaryote

Axiom
annotated source: secondary metabolite biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
database_cross_reference: GOC:jl

translation regulator activity
type: Class
definition: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
has_exact_synonym: translation factor activity
has_obo_namespace: molecular_function
id: GO:0045182
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation regulator activity
annotated property: definition
annotated target: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
database_cross_reference: GOC:ai

nutrient reservoir activity
type: Class
definition: Functions in the storage of nutritious substrates.
has_obo_namespace: molecular_function
has_related_synonym: storage protein
has_related_synonym: storage protein of fat body
has_related_synonym: yolk protein
id: GO:0045735
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.

Axiom
annotated source: nutrient reservoir activity
annotated property: definition
annotated target: Functions in the storage of nutritious substrates.
database_cross_reference: GOC:ai

cell motility
type: Class
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
has_exact_synonym: cell locomotion
has_exact_synonym: movement of a cell
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0048870
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell motility
annotated property: definition
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg

response to stimulus
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
has_alternative_id: GO:0051869
has_exact_synonym: physiological response to stimulus
has_obo_namespace: biological_process
id: GO:0050896
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf

protein maturation
type: Class
definition: Any process leading to the attainment of the full functional capacity of a protein.
has_obo_namespace: biological_process
id: GO:0051604
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein maturation
annotated property: definition
annotated target: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:ai

nucleobase-containing small molecule metabolic process
type: Class
definition: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
has_exact_synonym: nucleobase, nucleoside and nucleotide metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
id: GO:0055086
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: GOC:vw

molecular transducer activity
type: Class
definition: A compound molecular function in which an effector function is controlled by one or more regulatory components.
has_obo_namespace: molecular_function
id: GO:0060089
in_subset: gocheck do not annotate
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: molecular transducer activity
annotated property: definition
annotated target: A compound molecular function in which an effector function is controlled by one or more regulatory components.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pdt

molecular adaptor activity
type: Class
definition: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
has_alternative_id: GO:0032947
has_broad_synonym: protein complex scaffold activity
has_broad_synonym: protein-containing complex scaffold activity
has_exact_synonym: binding, bridging
has_obo_namespace: molecular_function
id: GO:0060090
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular adaptor activity
annotated property: definition
annotated target: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
database_cross_reference: GOC:mtg_MIT_16mar07
database_cross_reference: GOC:vw

membrane organization
type: Class
definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
created by: jl
creation date: 2010-02-08T02:43:11Z
has_alternative_id: GO:0016044
has_alternative_id: GO:0044802
has_exact_synonym: cellular membrane organisation
has_exact_synonym: cellular membrane organization
has_exact_synonym: membrane organisation
has_obo_namespace: biological_process
has_related_synonym: membrane organization and biogenesis
has_related_synonym: single-organism membrane organization
id: GO:0061024
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: membrane organization
annotated property: definition
annotated target: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: membrane organization
annotated property: has_exact_synonym
annotated target: membrane organisation
database_cross_reference: GOC:mah

Axiom
annotated source: membrane organization
annotated property: has_related_synonym
annotated target: membrane organization and biogenesis
database_cross_reference: GOC:mah

protein-containing complex assembly
type: Class
definition: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/22580
has_alternative_id: GO:0006461
has_alternative_id: GO:0034622
has_alternative_id: GO:0043623
has_exact_synonym: cellular protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecule complex assembly
has_related_synonym: cellular protein-containing complex assembly
has_related_synonym: chaperone activity
has_related_synonym: macromolecular complex assembly
has_related_synonym: macromolecule complex assembly
has_related_synonym: protein complex assembly
has_related_synonym: protein complex formation
id: GO:0065003
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: protein-containing complex assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
database_cross_reference: GOC:jl

cell wall organization or biogenesis
type: Class
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
created by: mah
creation date: 2010-01-13T03:19:38Z
has_alternative_id: GO:0070882
has_exact_synonym: cell wall organisation or biogenesis
has_exact_synonym: cell wall organization or biogenesis at cellular level
has_exact_synonym: cellular cell wall organisation or biogenesis
has_exact_synonym: cellular cell wall organization or biogenesis
has_obo_namespace: biological_process
id: GO:0071554
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cell wall organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organization or biogenesis at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular cell wall organisation or biogenesis
database_cross_reference: GOC:mah

nitrogen cycle metabolic process
type: Class
definition: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
created by: mah
creation date: 2010-09-30T05:21:03Z
database_cross_reference: Wikipedia:Nitrogen_cycle
has_obo_namespace: biological_process
id: GO:0071941
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: nitrogen cycle metabolic process
annotated property: definition
annotated target: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16675690
database_cross_reference: Wikipedia:Nitrogen_cycle

protein localization to membrane
type: Class
definition: A process in which a protein is transported to, or maintained in, a specific location in a membrane.
created by: mah
creation date: 2011-02-14T02:35:18Z
has_exact_synonym: protein localisation in membrane
has_exact_synonym: protein localization in membrane
has_obo_namespace: biological_process
id: GO:0072657
in_subset: goslim prokaryote

Axiom
annotated source: protein localization to membrane
annotated property: definition
annotated target: A process in which a protein is transported to, or maintained in, a specific location in a membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to membrane
annotated property: has_exact_synonym
annotated target: protein localisation in membrane
database_cross_reference: GOC:mah

toxin activity
type: Class
definition: Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
created by: tb
creation date: 2016-12-19T15:23:27Z
has_alternative_id: GO:0050827
database_cross_reference: Wikipedia:Toxin
has_exact_synonym: toxin receptor binding
has_obo_namespace: molecular_function
id: GO:0090729
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: toxin activity
annotated property: definition
annotated target: Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
database_cross_reference: GOC:pt

defense response to other organism
type: Class
subclass of: response to stimulus
definition: Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/22173
created by: dos
creation date: 2013-11-11T12:59:11Z
has_alternative_id: GO:0009814
has_narrow_synonym: defence response incompatible interaction
has_narrow_synonym: defence response to pathogen, incompatible interaction
has_narrow_synonym: defense response, incompatible interaction
has_narrow_synonym: resistance response to pathogen
has_obo_namespace: biological_process
id: GO:0098542
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: defense response to other organism
annotated property: definition
annotated target: Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
database_cross_reference: GOC:dos

cell adhesion mediator activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: cell adhesion
definition: The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/22959
has_exact_synonym: cell adhesion molecule
has_exact_synonym: protein binding involved in cell adhesion
has_obo_namespace: molecular_function
id: GO:0098631
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion mediator activity
annotated property: definition
annotated target: The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
database_cross_reference: GOC:vw
database_cross_reference: Wikipedia:Cell_adhesion

detoxification
type: Class
subclass of: Restriction
  on property: part of
  some values from: response to stimulus
definition: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
has_obo_namespace: biological_process
id: GO:0098754
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: detoxification
annotated property: definition
annotated target: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
database_cross_reference: GOC:dos

molecular function regulator activity
type: Class
definition: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
term tracker item: https://github.com/geneontology/go-ontology/issues/20854
term tracker item: https://github.com/geneontology/go-ontology/issues/20862
term tracker item: https://github.com/geneontology/go-ontology/issues/25165
has_exact_synonym: molecular function regulator
has_obo_namespace: molecular_function
id: GO:0098772
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular function regulator activity
annotated property: definition
annotated target: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pt

catalytic activity, acting on a protein
type: Class
definition: Catalytic activity that acts to modify a protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
created by: pg
creation date: 2017-09-14T10:32:59Z
has_obo_namespace: molecular_function
id: GO:0140096
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on a protein
annotated property: definition
annotated target: Catalytic activity that acts to modify a protein.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

catalytic activity, acting on DNA
type: Class
definition: Catalytic activity that acts to modify DNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
created by: pg
creation date: 2017-09-14T12:03:51Z
has_obo_namespace: molecular_function
id: GO:0140097
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on DNA
annotated property: definition
annotated target: Catalytic activity that acts to modify DNA.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

catalytic activity, acting on RNA
type: Class
definition: Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
created by: pg
creation date: 2017-09-14T12:05:21Z
has_obo_namespace: molecular_function
id: GO:0140098
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on RNA
annotated property: definition
annotated target: Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

molecular carrier activity
type: Class
definition: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/14221
term tracker item: https://github.com/geneontology/go-ontology/issues/20848
created by: pg
creation date: 2017-09-19T13:10:18Z
has_obo_namespace: molecular_function
id: GO:0140104
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.

Axiom
annotated source: molecular carrier activity
annotated property: definition
annotated target: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

transcription regulator activity
type: Class
definition: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/13588
term tracker item: https://github.com/geneontology/go-ontology/issues/23609
created by: pg
creation date: 2017-10-18T07:05:44Z
has_obo_namespace: molecular_function
id: GO:0140110
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: transcription regulator activity
annotated property: definition
annotated target: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:pg
database_cross_reference: GOC:txnOH-2018
database_cross_reference: Wikipedia:Transcription_factor

molecular sensor activity
type: Class
subclass of: molecular function regulator activity
definition: Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/28772
created by: pg
creation date: 2018-12-10T14:30:28Z
has_exact_synonym: small molecular sensor activity
has_exact_synonym: small molecule sensing activity
has_narrow_synonym: small molecule sensor activity
has_obo_namespace: molecular_function
id: GO:0140299
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular sensor activity
annotated property: definition
annotated target: Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
database_cross_reference: PMID:26328879

molecular sequestering activity
type: Class
definition: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
created by: pg
creation date: 2019-03-28T10:00:25Z
database_cross_reference: Reactome:R-HSA-3245898
has_obo_namespace: molecular_function
id: GO:0140313
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular sequestering activity
annotated property: definition
annotated target: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
database_cross_reference: PMID:13130076

TCN1 binds correnoids in the circulation
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3245898

ATP-dependent activity
type: Class
subclass of: Restriction
  on property: has part
  some values from: hydrolase activity
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324

carbohydrate derivative metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrate derivative.
created by: bf
creation date: 2012-07-12T04:05:09Z
has_exact_synonym: carbohydrate derivative metabolism
has_obo_namespace: biological_process
id: GO:1901135
in_subset: goslim agr
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrate derivative.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: has_exact_synonym
annotated target: carbohydrate derivative metabolism
database_cross_reference: GOC:TermGenie