# GORULE violations assigned by ARUK-UCL

## SUMMARY

This report generated on 2024-10-22

## Contents

[gorule-0000008](#gorule-0000008)[No annotations should be made to uninformative high level terms]{}

[gorule-0000020](#gorule-0000020)[Automatic repair of annotations to merged or obsoleted terms]{}

[gorule-0000046](#gorule-0000046)[The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.]{}

[gorule-0000061](#gorule-0000061)[Allowed gene product to term relations (gp2term)]{}

## MESSAGES

###gorule-0000008

No annotations should be made to uninformative high level terms

* total: 4
#### Messages
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:97321	Ngf	involved_in	GO:0043388	PMID:10362258	IMP		P	Beta-nerve growth factor		protein	taxon:10090	20180124	ARUK-UCL	has_input(UniProtKB:B2RWS6),has_input(UniProtKB:P38936),has_input(CHEBI:4705)|has_input(UniProtKB:O89090),has_input(UniProtKB:P38936),has_input(CHEBI:4705)|has_input(UniProtKB:O70494),has_input(UniProtKB:P38936),has_input(CHEBI:4705)	
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:95629	Slc6a13	enables	GO:0005368	PMID:22896705	IMP		F	Sodium- and chloride-dependent GABA transporter 2		protein	taxon:10090	20200605	ARUK-UCL	part_of(UBERON:0002107)	
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:87904	Actb	involved_in	GO:0032091	PMID:19118186	IDA		P	Actin, cytoplasmic 1		protein	taxon:10090	20171103	ARUK-UCL	has_input(UniProtKB:P61809),has_input(UniProtKB:P49615)	
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1341865	Mark3	involved_in	GO:0032092	PMID:9543386	ISS	UniProtKB:P27448	P	MAP/microtubule affinity-regulating kinase 3		protein	taxon:10090	20180328	ARUK-UCL	has_input(UniProtKB:P48967),has_input(UniProtKB:P63101)	
`

###gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 6
#### Messages
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:97810	Ptprc	involved_in	GO:0044855	PMID:15661907	IGI	UniProtKB:P05480	P	Receptor-type tyrosine-protein phosphatase C		protein	taxon:10090	20180724	ARUK-UCL	occurs_in(CL:0000084),has_end_location(GO:0042101),part_of(GO:0031668),occurs_in(GO:0098857)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:894311	Lilrb3	involved_in	GO:0035307	PMID:24052308	IGI	ComplexPortal:CPX-1134	P	Leukocyte immunoglobulin-like receptor subfamily B member 3		protein	taxon:10090	20170725	ARUK-UCL	occurs_in(CL:0010012),has_input(UniProtKB:P18760)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1196625	Fzd1	involved_in	GO:0036520	PMID:21752258	IMP		P	Frizzled-1		protein	taxon:10090	20190918	ARUK-UCL	occurs_in(CL:2000097),causally_upstream_of(GO:1903204)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1196625	Fzd1	involved_in	GO:0060070	PMID:21752258	IMP		P	Frizzled-1		protein	taxon:10090	20190918	ARUK-UCL	occurs_in(CL:2000097),part_of(GO:0036520),part_of(GO:1903204)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:98953	Wnt1	involved_in	GO:0060070	PMID:21752258	IMP		P	Proto-oncogene Wnt-1		protein	taxon:10090	20190918	ARUK-UCL	occurs_in(CL:2000097),part_of(GO:0036520),part_of(GO:1903204)	
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI	MGI:95665	Gba1	acts_upstream_of_or_within	GO:1904925	PMID:23707074	IMP		P	Lysosomal acid glucosylceramidase		protein	taxon:10090	20230704	ARUK-UCL	occurs_in(UBERON:0001891),occurs_in(CL:0000540)|occurs_in(UBERON:0001891),occurs_in(CL:0000127)	
`

###gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 3
#### Messages
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1196458	Scarb2	enables	GO:0042803	PMID:29199275	IPI	UniProtKB:O35114	F	Lysosome membrane protein 2		protein	taxon:10090	20181031	ARUK-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:97275	Myod1	enables	GO:0042803	PMID:10652346	IPI	UniProtKB:P10085	F	Myoblast determination protein 1		protein	taxon:10090	20230314	ARUK-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:894311	Lilrb3	enables	GO:0042803	PMID:24052308	IPI	UniProtKB:P97484	F	Leukocyte immunoglobulin-like receptor subfamily B member 3		protein	taxon:10090	20230314	ARUK-UCL	causally_upstream_of(GO:0001540)	
`

###gorule-0000061

Allowed gene product to term relations (gp2term)

* total: 2
#### Messages
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI	MGI:96247	Hsp90ab1	is_active_in	GO:0101031	PMID:17517623	IMP		C	Heat shock protein HSP 90-beta		protein	taxon:10090	20240320	ARUK-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI	MGI:2442926	Mettl14	is_active_in	GO:0036396	PMID:29290617	IDA		C	N6-adenosine-methyltransferase non-catalytic subunit		protein	taxon:10090	20240206	ARUK-UCL		
`