# GORULE violations assigned by BHF-UCL

## SUMMARY

This report generated on 2024-10-22

## Contents

[gorule-0000005](#gorule-0000005)[IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding'']{}

[gorule-0000008](#gorule-0000008)[No annotations should be made to uninformative high level terms]{}

[gorule-0000016](#gorule-0000016)[With/From: IC annotations require a With/From GO ID]{}

[gorule-0000020](#gorule-0000020)[Automatic repair of annotations to merged or obsoleted terms]{}

[gorule-0000046](#gorule-0000046)[The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.]{}

[gorule-0000061](#gorule-0000061)[Allowed gene product to term relations (gp2term)]{}

## MESSAGES

###gorule-0000005

IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding''

* total: 2
#### Messages
* WARNING - Violates GO Rule:GORULE:0000005: IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to 'binding ; GO:0005488' or 'protein binding ; GO:0005515'--`MGI	MGI:3613677	Shank1	enables	GO:0005515	GO_REF:0000024	ISS	UniProtKB:Q9WV48	F	SH3 and multiple ankyrin repeat domains protein 1		protein	taxon:10090	20131017	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000005: IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to 'binding ; GO:0005488' or 'protein binding ; GO:0005515'--`MGI	MGI:1277959	Dlg4	enables	GO:0005515	GO_REF:0000024	ISS	UniProtKB:P31016	F	Disks large homolog 4		protein	taxon:10090	20131017	BHF-UCL		
`

###gorule-0000008

No annotations should be made to uninformative high level terms

* total: 9
#### Messages
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1095400	Zfpm1	involved_in	GO:0032091	PMID:18063754	IDA		P	Zinc finger protein ZFPM1		protein	taxon:10090	20110810	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:88246	Anxa2	involved_in	GO:1905597	PMID:22848640	IMP		P	Annexin A2		protein	taxon:10090	20161031	BHF-UCL	occurs_in(UBERON:0002107),part_of(GO:0001921),part_of(GO:0032804),part_of(GO:1905599),part_of(GO:1905597),part_of(GO:1905602)	
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:98310	Ski	involved_in	GO:0043388	GO_REF:0000024	ISS	UniProtKB:P12755	P	Ski oncogene		protein	taxon:10090	20110403	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1346859	Mapk3	involved_in	GO:2000657	PMID:20037141	IMP		P	Mitogen-activated protein kinase 3		protein	taxon:10090	20110707	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:98419	Sri	involved_in	GO:2000678	PMID:22338092	IMP		P	Sorcin		protein	taxon:10090	20130128	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:2443732	Dna2	involved_in	GO:0090304	PMID:23604072	IDA		P	DNA replication ATP-dependent helicase/nuclease DNA2		protein	taxon:10090	20151223	BHF-UCL	part_of(GO:1902990)	
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1345675	Trib3	involved_in	GO:0032092	PMID:16794074	IDA		P	Tribbles homolog 3		protein	taxon:10090	20100430	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1915756	Ctnnbip1	involved_in	GO:0043392	PMID:11751639	IDA		P	Beta-catenin-interacting protein 1		protein	taxon:10090	20100723	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:1314872	Hipk2	involved_in	GO:0032092	PMID:16407227	IDA		P	Homeodomain-interacting protein kinase 2		protein	taxon:10090	20111205	BHF-UCL		
`

###gorule-0000016

With/From: IC annotations require a With/From GO ID

* total: 1
#### Messages
* WARNING - Violates GO Rule:GORULE:0000016: All IC annotations should include a GO ID in the "With/From" column that is also different from the entry in the "GO ID" column--`MGI	MGI:97362	Nos3	located_in	GO:0005737	PMID:11732991	IC	GO:0005737	C	Nitric oxide synthase 3		protein	taxon:10090	20180821	BHF-UCL	part_of(CL:0000115),part_of(UBERON:0011742),existence_overlaps(GO:0003180)	
`

###gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 6
#### Messages
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1346086	Aplnr	involved_in	GO:0060183	PMID:23603510	IMP		P	Apelin receptor		protein	taxon:10090	20210204	BHF-UCL	causally_upstream_of(GO:0031065)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:88276	Ctnnb1	enables	GO:1990226	PMID:22723415	IPI	UniProtKB:O15047	F	Catenin beta-1		protein	taxon:10090	20210113	BHF-UCL	occurs_in(GO:0005634),occurs_in(CL:0002322),has_input(UniProtKB:E9PYH6),part_of(GO:0051571)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:88276	Ctnnb1	enables	GO:0003713	PMID:22723415	IDA		F	Catenin beta-1		protein	taxon:10090	20210113	BHF-UCL	has_input(UniProtKB:O70372),occurs_in(CL:0002322),causally_upstream_of(GO:0051973)	
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:88276	Ctnnb1	involved_in	GO:0045944	PMID:22723415	IMP		P	Catenin beta-1		protein	taxon:10090	20210113	BHF-UCL	has_input(UniProtKB:O70372),occurs_in(CL:0002322),causally_upstream_of(GO:0051973)	
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI	MGI:98262	Ccl5	involved_in	GO:0031328	GO_REF:0000024	ISS	UniProtKB:P13501	P	C-C motif chemokine 5		protein	taxon:10090	20110224	BHF-UCL		
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI	MGI:87866	Acadl	involved_in	GO:0044242	PMID:9861014	IMP		P	Long-chain specific acyl-CoA dehydrogenase, mitochondrial		protein	taxon:10090	20091117	BHF-UCL		
`

###gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 24
#### Messages
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1195972	Terf2	enables	GO:0042803	PMID:9326950	IPI	UniProtKB:O35144	F	Telomeric repeat-binding factor 2		protein	taxon:10090	20081216	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:99665	Syt3	enables	GO:0042803	PMID:10531343	IDA		F	Synaptotagmin-3		protein	taxon:10090	20110630	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1201414	Cer1	enables	GO:0042803	PMID:10748465	IDA		F	Cerberus		protein	taxon:10090	20120213	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1270845	Cidea	enables	GO:0042803	PMID:17080483	IDA		F	Lipid transferase CIDEA		protein	taxon:10090	20071212	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1277234	Tbx15	enables	GO:0042803	PMID:17584735	IPI	UniProtKB:O70306	F	T-box transcription factor TBX15		protein	taxon:10090	20191030	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1339753	Csf1	enables	GO:0042803	PMID:19017797	IPI	UniProtKB:P07141	F	Macrophage colony-stimulating factor 1		protein	taxon:10090	20100311	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1339758	Csf1r	enables	GO:0042803	PMID:19017797	IPI	UniProtKB:P09581	F	Macrophage colony-stimulating factor 1 receptor		protein	taxon:10090	20090115	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:97361	Nos2	enables	GO:0042803	PMID:9271491	IDA		F	Nitric oxide synthase, inducible		protein	taxon:10090	20080725	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:98262	Ccl5	enables	GO:0042803	GO_REF:0000024	ISS	UniProtKB:P13501	F	C-C motif chemokine 5		protein	taxon:10090	20240316	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:104593	Xcl1	enables	GO:0042803	GO_REF:0000024	ISS	UniProtKB:P47992	F	Lymphotactin		protein	taxon:10090	20110403	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:108050	Ext2	enables	GO:0042803	PMID:10639137	IDA		F	Exostosin-2		protein	taxon:10090	20080228	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:103580	Hand2	enables	GO:0042803	PMID:11812799	IPI	UniProtKB:Q61039	F	Heart- and neural crest derivatives-expressed protein 2		protein	taxon:10090	20090827	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:95392	Eng	enables	GO:0042803	PMID:8194490	IPI	UniProtKB:Q63961	F	Endoglin		protein	taxon:10090	20081107	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:103577	Hand1	enables	GO:0042803	PMID:10924525	IPI	UniProtKB:Q64279	F	Heart- and neural crest derivatives-expressed protein 1		protein	taxon:10090	20090826	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:2442682	Slc30a8	enables	GO:0042803	PMID:19095428	IPI	UniProtKB:Q8BGG0	F	Proton-coupled zinc antiporter SLC30A8		protein	taxon:10090	20100128	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:2149946	Gopc	enables	GO:0042803	PMID:11520064	IPI	UniProtKB:Q8BH60	F	Golgi-associated PDZ and coiled-coil motif-containing protein		protein	taxon:10090	20110330	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:2180781	Slc8b1	enables	GO:0042803	PMID:20018762	IPI	UniProtKB:Q925Q3	F	Mitochondrial sodium/calcium exchanger protein		protein	taxon:10090	20140904	BHF-UCL	occurs_in(UBERON:0000948)|occurs_in(UBERON:0000955)	
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1930704	Bhlhe41	enables	GO:0042803	PMID:17487425	IPI	UniProtKB:Q99PV5	F	Class E basic helix-loop-helix protein 41		protein	taxon:10090	20111216	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1915050	Dgat2	enables	GO:0042803	PMID:21680734	IPI	UniProtKB:Q9DCV3	F	Diacylglycerol O-acyltransferase 2		protein	taxon:10090	20111130	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1923615	Tbx18	enables	GO:0042803	PMID:17584735	IPI	UniProtKB:Q9EPZ6	F	T-box transcription factor TBX18		protein	taxon:10090	20191030	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1859546	Syt10	enables	GO:0042803	PMID:10531343	IDA		F	Synaptotagmin-10		protein	taxon:10090	20110630	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1859544	Syt6	enables	GO:0042803	PMID:10531343	IDA		F	Synaptotagmin-6		protein	taxon:10090	20110630	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1316652	Prmt2	enables	GO:0042803	GO_REF:0000024	ISS	UniProtKB:P55345	F	Protein arginine N-methyltransferase 2		protein	taxon:10090	20110403	BHF-UCL		
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1351322	Mixl1	enables	GO:0042803	PMID:22164283	IPI	UniProtKB:Q9WUI0	F	Homeobox protein MIXL1		protein	taxon:10090	20121029	BHF-UCL		
`

###gorule-0000061

Allowed gene product to term relations (gp2term)

* total: 3
#### Messages
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI	MGI:109244	Sema4d	is_active_in	GO:0002116	PMID:22019888	IMP		C	Semaphorin-4D		protein	taxon:10090	20230823	BHF-UCL	occurs_in(CL:0000062)	
`
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI	MGI:95410	Erbb2	is_active_in	GO:0002116	PMID:22019888	IMP		C	Receptor tyrosine-protein kinase erbB-2		protein	taxon:10090	20230823	BHF-UCL	occurs_in(CL:0000062)	
`
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`MGI	MGI:2154238	Plxnb1	is_active_in	GO:0002116	PMID:22019888	IMP		C	Plexin-B1		protein	taxon:10090	20230823	BHF-UCL	occurs_in(CL:0000062)	
`