goslim mouse.owl
type: Ontology
version IRI: goslim mouse.owl
version info: 2024-02-21

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

immune system process
type: Class
definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
RO_0002161: NCBITaxon 4895
database_cross_reference: Wikipedia:Immune_system
has_obo_namespace: biological_process
id: GO:0002376
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).

Axiom
annotated source: immune system process
annotated property: definition
annotated target: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

DNA binding
type: Class
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

DNA-binding transcription factor activity
type: Class
subclass of: Restriction
  on property: has part
  some values from: DNA binding
definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/15704
term tracker item: https://github.com/geneontology/go-ontology/issues/16534
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
created by: krc
creation date: 2010-10-21T04:37:54Z
has_alternative_id: GO:0000130
has_alternative_id: GO:0001071
has_alternative_id: GO:0001130
has_alternative_id: GO:0001131
has_alternative_id: GO:0001151
has_alternative_id: GO:0001199
has_alternative_id: GO:0001204
has_broad_synonym: nucleic acid binding transcription factor activity
has_broad_synonym: transcription factor activity
has_exact_synonym: DNA binding transcription factor activity
has_exact_synonym: gene-specific transcription factor activity
has_exact_synonym: sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has_narrow_synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has_narrow_synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has_narrow_synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
has_obo_namespace: molecular_function
id: GO:0003700
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast
comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.

Axiom
annotated source: DNA-binding transcription factor activity
annotated property: definition
annotated target: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:txnOH-2018

RNA binding
type: Class
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

signaling receptor binding
type: Class
definition: Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
has_broad_synonym: receptor binding
database_cross_reference: Wikipedia:Ligand_(biochemistry)
has_narrow_synonym: receptor ligand
has_obo_namespace: molecular_function
has_related_synonym: receptor-associated protein activity
id: GO:0005102
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim plant
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.

Axiom
annotated source: signaling receptor binding
annotated property: definition
annotated target: Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ceb
database_cross_reference: ISBN:0198506732

transporter activity
type: Class
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
has_alternative_id: GO:0005478
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

extracellular region
type: Class
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:go_curators

nucleus
type: Class
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:go_curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

mitochondrion
type: Class
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

endosome
type: Class
subclass of: cytoplasmic vesicle
definition: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: NIF_Subcellular:sao1720343330
database_cross_reference: Wikipedia:Endosome
has_obo_namespace: cellular_component
id: GO:0005768
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: endosome
annotated property: definition
annotated target: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:19696797

vacuole
type: Class
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

endoplasmic reticulum
type: Class
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
database_cross_reference: ISBN:0198506732

cytosol
type: Class
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
id: GO:0005829
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cytosol
annotated property: definition
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:jl

cytoskeleton
type: Class
subclass of: non-membrane-bounded organelle
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

DNA-templated transcription
type: Class
definition: The synthesis of an RNA transcript from a DNA template.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
term tracker item: https://github.com/geneontology/go-ontology/issues/16737
term tracker item: https://github.com/geneontology/go-ontology/issues/22258
term tracker item: https://github.com/geneontology/go-ontology/issues/22555
has_alternative_id: GO:0001121
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database_cross_reference: Wikipedia:Transcription_(genetics)
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: transcription, DNA-dependent
has_exact_synonym: transcription, DNA-templated
has_narrow_synonym: bacterial transcription
has_narrow_synonym: transcription from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
id: GO:0006351
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: DNA-templated transcription
annotated property: definition
annotated target: The synthesis of an RNA transcript from a DNA template.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription
annotated property: has_exact_synonym
annotated target: transcription, DNA-dependent
database_cross_reference: GOC:txnOH

lipid metabolic process
type: Class
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

cytoskeletal protein binding
type: Class
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

cell population proliferation
type: Class
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
RO_0002161: NCBITaxon 4751
has_obo_namespace: biological_process
has_related_synonym: cell proliferation
id: GO:0008283
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.

Axiom
annotated source: cell population proliferation
annotated property: definition
annotated target: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mb

lipid binding
type: Class
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

programmed cell death
type: Class
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24835
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim prokaryote
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

cellular component organization
type: Class
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
has_exact_synonym: cell organisation
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
has_obo_namespace: biological_process
has_related_synonym: cell organization and biogenesis
id: GO:0016043
in_subset: goslim agr
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cellular component organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation in other organism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_related_synonym
annotated target: cell organization and biogenesis
database_cross_reference: GOC:mah

oxidoreductase activity
type: Class
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-209921
database_cross_reference: Reactome:R-HSA-209960
database_cross_reference: Reactome:R-HSA-3095889
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-5662660
database_cross_reference: Reactome:R-HSA-8878581
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: GOC:go_curators

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

Monoiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209921

Diiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209960

MMACHC dealkylates RCbl
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3095889

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

Dopachrome is transformed to DHICA by DCT
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5662660

TYRP1 oxidises DHICA to IQCA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8878581

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

transferase activity
type: Class
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: ISBN:0198506732

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

hydrolase activity
type: Class
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

ligase activity
type: Class
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: GOC:mah

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

protein metabolic process
type: Class
definition: The chemical reactions and pathways involving a protein. Includes protein modification.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0006411
has_alternative_id: GO:0044267
has_alternative_id: GO:0044268
database_cross_reference: Wikipedia:Protein_metabolism
has_exact_synonym: cellular protein metabolic process
has_exact_synonym: cellular protein metabolism
has_exact_synonym: protein metabolic process and modification
has_exact_synonym: protein metabolism
has_exact_synonym: protein metabolism and modification
has_narrow_synonym: multicellular organismal protein metabolic process
has_obo_namespace: biological_process
id: GO:0019538
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: protein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a protein. Includes protein modification.
database_cross_reference: GOC:ma

signaling
type: Class
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
created by: jl
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has_exact_synonym: biological signaling
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

Axiom
annotated source: signaling
annotated property: definition
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling
annotated property: has_related_synonym
annotated target: signalling process
database_cross_reference: GOC:mah

cell differentiation
type: Class
definition: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
term tracker item: https://github.com/geneontology/go-ontology/issues/24390
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
id: GO:0030154
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

enzyme regulator activity
type: Class
definition: Binds to and modulates the activity of an enzyme.
has_alternative_id: GO:0010576
has_exact_synonym: catalytic regulator activity
has_exact_synonym: enzyme modulator
has_narrow_synonym: metalloenzyme regulator activity
has_obo_namespace: molecular_function
id: GO:0030234
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: This term should only be used in cases when the regulator directly interacts with the enzyme.

Axiom
annotated source: enzyme regulator activity
annotated property: definition
annotated target: Binds to and modulates the activity of an enzyme.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: enzyme regulator activity
annotated property: has_exact_synonym
annotated target: catalytic regulator activity
database_cross_reference: GOC:dph

cytoplasmic vesicle
type: Class
definition: A vesicle found in the cytoplasm of a cell.
has_alternative_id: GO:0016023
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic membrane bounded vesicle
has_related_synonym: cytoplasmic membrane-enclosed vesicle
has_related_synonym: cytoplasmic, membrane-bounded vesicle
id: GO:0031410
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim yeast

Axiom
annotated source: cytoplasmic vesicle
annotated property: definition
annotated target: A vesicle found in the cytoplasm of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicles

organelle envelope
type: Class
definition: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
has_obo_namespace: cellular_component
id: GO:0031967
in_subset: goslim mouse

Axiom
annotated source: organelle envelope
annotated property: definition
annotated target: A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz

protein-containing complex
type: Class
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
has_alternative_id: GO:0043234
has_exact_synonym: macromolecular complex
has_exact_synonym: macromolecule complex
has_exact_synonym: protein containing complex
has_narrow_synonym: protein complex
has_narrow_synonym: protein-protein complex
has_obo_namespace: cellular_component
id: GO:0032991
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.

Axiom
annotated source: protein-containing complex
annotated property: definition
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

signaling receptor activity
type: Class
definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
created by: bf
creation date: 2011-08-01T02:45:27Z
has_alternative_id: GO:0004872
has_alternative_id: GO:0019041
has_broad_synonym: receptor activity
has_exact_synonym: receptor activity involved in signal transduction
has_exact_synonym: signalling receptor activity
has_obo_namespace: molecular_function
id: GO:0038023
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: signaling receptor activity
annotated property: definition
annotated target: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
database_cross_reference: GOC:bf
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity involved in signal transduction
database_cross_reference: GOC:bf

homeostatic process
type: Class
definition: Any biological process involved in the maintenance of an internal steady state.
has_alternative_id: GO:0032844
has_alternative_id: GO:0032845
has_alternative_id: GO:0032846
has_exact_synonym: homeostasis
has_narrow_synonym: activation of homeostatic process
has_narrow_synonym: inhibition of homeostatic process
has_obo_namespace: biological_process
has_related_synonym: negative regulation of homeostatic process
has_related_synonym: positive regulation of homeostatic process
has_related_synonym: regulation of homeostatic process
id: GO:0042592
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim mouse

Axiom
annotated source: homeostatic process
annotated property: definition
annotated target: Any biological process involved in the maintenance of an internal steady state.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172

cell projection
type: Class
definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
has_broad_synonym: cell process
has_broad_synonym: cellular process
has_exact_synonym: cellular projection
has_obo_namespace: cellular_component
id: GO:0042995
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: cell projection
annotated property: definition
annotated target: A prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: http://www.cogsci.princeton.edu/~wn/

non-membrane-bounded organelle
type: Class
definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
term tracker item: https://github.com/geneontology/go-ontology/issues/21881
database_cross_reference: NIF_Subcellular:sao1456184038
has_exact_synonym: non-membrane-enclosed organelle
has_obo_namespace: cellular_component
has_related_synonym: biological condensate
id: GO:0043228
in_subset: goslim mouse

Axiom
annotated source: non-membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: GOC:go_curators

organelle lumen
type: Class
definition: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
has_obo_namespace: cellular_component
id: GO:0043233
in_subset: goslim mouse

Axiom
annotated source: organelle lumen
annotated property: definition
annotated target: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

synapse
type: Class
definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: NIF_Subcellular:sao914572699
database_cross_reference: Wikipedia:Chemical_synapse
has_exact_synonym: synaptic junction
has_narrow_synonym: mixed synapse
has_obo_namespace: cellular_component
has_related_synonym: electrotonic synapse
id: GO:0045202
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim synapse

Axiom
annotated source: synapse
annotated property: definition
annotated target: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: GOC:aruk
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:24619342
database_cross_reference: PMID:29383328
database_cross_reference: PMID:31998110

Axiom
annotated source: synapse
annotated property: has_narrow_synonym
annotated target: mixed synapse
database_cross_reference: NIF_Subcellular:sao1506103497

Axiom
annotated source: synapse
annotated property: has_related_synonym
annotated target: electrotonic synapse
database_cross_reference: NIF_Subcellular:sao1311109124

system development
type: Class
definition: The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
has_obo_namespace: biological_process
id: GO:0048731
in_subset: goslim mouse

Axiom
annotated source: system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

response to stimulus
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
has_alternative_id: GO:0051869
has_exact_synonym: physiological response to stimulus
has_obo_namespace: biological_process
id: GO:0050896
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf

establishment of localization
type: Class
definition: Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
term tracker item: https://github.com/geneontology/go-ontology/issues/24200
has_exact_synonym: establishment of localisation
has_obo_namespace: biological_process
id: GO:0051234
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir

Axiom
annotated source: establishment of localization
annotated property: definition
annotated target: Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dos

Axiom
annotated source: establishment of localization
annotated property: has_exact_synonym
annotated target: establishment of localisation
database_cross_reference: GOC:mah

carbohydrate derivative binding
type: Class
definition: Binding to a carbohydrate derivative.
created by: pr
creation date: 2012-08-02T13:03:39Z
has_obo_namespace: molecular_function
id: GO:0097367
in_subset: goslim agr
in_subset: goslim mouse

Axiom
annotated source: carbohydrate derivative binding
annotated property: definition
annotated target: Binding to a carbohydrate derivative.
database_cross_reference: GOC:pr

carbohydrate derivative metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrate derivative.
created by: bf
creation date: 2012-07-12T04:05:09Z
has_exact_synonym: carbohydrate derivative metabolism
has_obo_namespace: biological_process
id: GO:1901135
in_subset: goslim agr
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrate derivative.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: has_exact_synonym
annotated target: carbohydrate derivative metabolism
database_cross_reference: GOC:TermGenie

preceded by
database_cross_reference: BFO:0000062
has_obo_namespace: external
id: preceded_by
shorthand: preceded_by

precedes
database_cross_reference: BFO:0000063
has_obo_namespace: external
id: precedes
shorthand: precedes

results in
created by: cjm
creation date: 2012-03-14T10:35:44Z
database_cross_reference: GOREL:0000040
has_obo_namespace: external
id: results_in
shorthand: results_in
comment: This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.

results in division of
database_cross_reference: GOREL:0001019
has_obo_namespace: external
id: results_in_division_of
shorthand: results_in_division_of
comment: use occurs_in

results in distribution of
database_cross_reference: GOREL:0002003
has_obo_namespace: external
id: results_in_distribution_of
shorthand: results_in_distribution_of

results in fission of
database_cross_reference: GOREL:0002004
has_obo_namespace: external
id: results_in_fission_of
shorthand: results_in_fission_of

results in maintenance of
database_cross_reference: GOREL:0012006
has_obo_namespace: external
id: results_in_maintenance_of
shorthand: results_in_maintenance_of

bearer of
database_cross_reference: RO:0000053
has_obo_namespace: external
id: bearer_of
shorthand: bearer_of

participates in
database_cross_reference: RO:0000056
has_obo_namespace: external
id: participates_in
shorthand: participates_in

has participant
database_cross_reference: RO:0000057
has_obo_namespace: external
id: has_participant
shorthand: has_participant

bounding layer of
database_cross_reference: RO:0002007
has_obo_namespace: external
id: bounding_layer_of
shorthand: bounding_layer_of

coincident with
database_cross_reference: RO:0002008
has_obo_namespace: external
id: coincident_with
shorthand: coincident_with

regulates in other organism
database_cross_reference: RO:0002010
has_obo_namespace: external
id: regulates_in_other_organism
shorthand: regulates_in_other_organism

has regulatory component activity
database_cross_reference: RO:0002013
has_obo_namespace: external
id: has_regulatory_component_activity
shorthand: has_regulatory_component_activity

has negative regulatory component activity
database_cross_reference: RO:0002014
has_obo_namespace: external
id: has_negative_regulatory_component_activity
shorthand: has_negative_regulatory_component_activity

has necessary component activity
database_cross_reference: RO:0002016
has_obo_namespace: external
id: has_necessary_component_activity
shorthand: has_necessary_component_activity

immediately preceded by
database_cross_reference: RO:0002087
has_obo_namespace: external
id: immediately_preceded_by
shorthand: immediately_preceded_by

immediately precedes
database_cross_reference: RO:0002090
has_obo_namespace: external
id: immediately_precedes
shorthand: immediately_precedes

overlaps
database_cross_reference: RO:0002131
has_obo_namespace: external
id: overlaps
shorthand: overlaps

has component
database_cross_reference: RO:0002180
has_obo_namespace: external
id: has_component
shorthand: has_component

capable of
database_cross_reference: RO:0002215
has_obo_namespace: external
id: capable_of
shorthand: capable_of

capable of part of
database_cross_reference: RO:0002216
has_obo_namespace: external
id: capable_of_part_of
shorthand: capable_of_part_of

adjacent to
database_cross_reference: RO:0002220
has_obo_namespace: external
id: adjacent_to
shorthand: adjacent_to

starts with
database_cross_reference: RO:0002224
has_obo_namespace: external
id: starts_with
shorthand: starts_with

ends with
database_cross_reference: RO:0002230
has_obo_namespace: external
id: ends_with
shorthand: ends_with

has start location
database_cross_reference: RO:0002231
has_obo_namespace: external
id: has_start_location
shorthand: has_start_location

has end location
database_cross_reference: RO:0002232
has_obo_namespace: external
id: has_end_location
shorthand: has_end_location

has input
database_cross_reference: RO:0002233
has_obo_namespace: external
id: has_input
shorthand: has_input

has output
database_cross_reference: RO:0002234
has_obo_namespace: external
id: has_output
shorthand: has_output

results in developmental progression of
database_cross_reference: RO:0002295
has_obo_namespace: external
id: results_in_developmental_progression_of
shorthand: results_in_developmental_progression_of

results in development of
database_cross_reference: RO:0002296
has_obo_namespace: external
id: results_in_development_of
shorthand: results_in_development_of

results in formation of
database_cross_reference: RO:0002297
has_obo_namespace: external
id: results_in_formation_of
shorthand: results_in_formation_of

results in morphogenesis of
database_cross_reference: RO:0002298
has_obo_namespace: external
id: results_in_morphogenesis_of
shorthand: results_in_morphogenesis_of

results in maturation of
database_cross_reference: RO:0002299
has_obo_namespace: external
id: results_in_maturation_of
shorthand: results_in_maturation_of

causally upstream of, positive effect
database_cross_reference: RO:0002304
has_obo_namespace: external
id: causally_upstream_of,_positive_effect
shorthand: causally_upstream_of,_positive_effect

causally upstream of, negative effect
database_cross_reference: RO:0002305
has_obo_namespace: external
id: causally_upstream_of,_negative_effect
shorthand: causally_upstream_of,_negative_effect

results in acquisition of features of
database_cross_reference: RO:0002315
has_obo_namespace: external
id: results_in_acquisition_of_features_of
shorthand: results_in_acquisition_of_features_of

regulates levels of
database_cross_reference: RO:0002332
has_obo_namespace: external
id: regulates_levels_of
shorthand: regulates_levels_of

regulated by
database_cross_reference: RO:0002334
has_obo_namespace: external
id: regulated_by
shorthand: regulated_by

negatively regulated by
database_cross_reference: RO:0002335
has_obo_namespace: external
id: negatively_regulated_by
shorthand: negatively_regulated_by

positively regulated by
database_cross_reference: RO:0002336
has_obo_namespace: external
id: positively_regulated_by
shorthand: positively_regulated_by

has target start location
database_cross_reference: RO:0002338
has_obo_namespace: external
id: has_target_start_location
shorthand: has_target_start_location

has target end location
database_cross_reference: RO:0002339
has_obo_namespace: external
id: has_target_end_location
shorthand: has_target_end_location

results in transport along
database_cross_reference: RO:0002341
has_obo_namespace: external
id: results_in_transport_along
shorthand: results_in_transport_along

results in transport across
database_cross_reference: RO:0002342
has_obo_namespace: external
id: results_in_transport_across
shorthand: results_in_transport_across

results in growth of
database_cross_reference: RO:0002343
has_obo_namespace: external
id: results_in_growth_of
shorthand: results_in_growth_of

results in transport to from or in
database_cross_reference: RO:0002344
has_obo_namespace: external
id: results_in_transport_to_from_or_in
shorthand: results_in_transport_to_from_or_in

results in commitment to
database_cross_reference: RO:0002348
has_obo_namespace: external
id: results_in_commitment_to
shorthand: results_in_commitment_to

results in determination of
database_cross_reference: RO:0002349
has_obo_namespace: external
id: results_in_determination_of
shorthand: results_in_determination_of

output of
database_cross_reference: RO:0002353
has_obo_namespace: external
id: output_of
shorthand: output_of

results in structural organization of
database_cross_reference: RO:0002355
has_obo_namespace: external
id: results_in_structural_organization_of
shorthand: results_in_structural_organization_of

results in specification of
database_cross_reference: RO:0002356
has_obo_namespace: external
id: results_in_specification_of
shorthand: results_in_specification_of

causally downstream of
database_cross_reference: RO:0002404
has_obo_namespace: external
id: causally_downstream_of
shorthand: causally_downstream_of

immediately causally downstream of
database_cross_reference: RO:0002405
has_obo_namespace: external
id: immediately_causally_downstream_of
shorthand: immediately_causally_downstream_of

causally upstream of
database_cross_reference: RO:0002411
has_obo_namespace: external
id: causally_upstream_of
shorthand: causally_upstream_of

immediately causally upstream of
database_cross_reference: RO:0002412
has_obo_namespace: external
id: immediately_causally_upstream_of
shorthand: immediately_causally_upstream_of

causally upstream of or within
database_cross_reference: RO:0002418
has_obo_namespace: external
id: causally_upstream_of_or_within
shorthand: causally_upstream_of_or_within

causally downstream of or within
database_cross_reference: RO:0002427
has_obo_namespace: external
id: causally_downstream_of_or_within
shorthand: causally_downstream_of_or_within

has intermediate
database_cross_reference: RO:0002505
has_obo_namespace: external
id: has_intermediate
shorthand: has_intermediate

results in movement of
database_cross_reference: RO:0002565
has_obo_namespace: external
id: results_in_movement_of
shorthand: results_in_movement_of

directly regulates
database_cross_reference: RO:0002578
has_obo_namespace: external
id: directly_regulates
shorthand: directly_regulates

results in assembly of
database_cross_reference: RO:0002588
has_obo_namespace: external
id: results_in_assembly_of
shorthand: results_in_assembly_of

results in disassembly of
database_cross_reference: RO:0002590
has_obo_namespace: external
id: results_in_disassembly_of
shorthand: results_in_disassembly_of

results in remodeling of
database_cross_reference: RO:0002591
has_obo_namespace: external
id: results_in_remodeling_of
shorthand: results_in_remodeling_of

results in organization of
database_cross_reference: RO:0002592
has_obo_namespace: external
id: results_in_organization_of
shorthand: results_in_organization_of

process has causal agent
database_cross_reference: RO:0002608
has_obo_namespace: external
id: process_has_causal_agent
shorthand: process_has_causal_agent

directly positively regulates
database_cross_reference: RO:0002629
has_obo_namespace: external
id: directly_positively_regulates
shorthand: directly_positively_regulates

directly negatively regulates
database_cross_reference: RO:0002630
has_obo_namespace: external
id: directly_negatively_regulates
shorthand: directly_negatively_regulates

produces
database_cross_reference: RO:0003000
has_obo_namespace: external
id: produces
shorthand: produces

produced by
database_cross_reference: RO:0003001
has_obo_namespace: external
id: produced_by
shorthand: produced_by

has primary input or output
database_cross_reference: RO:0004007
has_obo_namespace: external
id: has_primary_input_or_output
shorthand: has_primary_input_or_output

has primary output
database_cross_reference: RO:0004008
has_obo_namespace: external
id: has_primary_output
shorthand: has_primary_output

has primary input
database_cross_reference: RO:0004009
has_obo_namespace: external
id: has_primary_input
shorthand: has_primary_input

has small molecule activator
database_cross_reference: RO:0012001
has_obo_namespace: external
id: has_small_molecule_activator
shorthand: has_small_molecule_activator

acts on population of
database_cross_reference: RO:0012003
has_obo_namespace: external
id: acts_on_population_of
shorthand: acts_on_population_of

results in fusion of
database_cross_reference: RO:0012008
has_obo_namespace: external
id: results_in_fusion_of
shorthand: results_in_fusion_of

regulates characteristic
database_cross_reference: RO:0019000
has_obo_namespace: gene_ontology
id: regulates_characteristic
shorthand: regulates_characteristic

positively regulates characteristic
database_cross_reference: RO:0019001
has_obo_namespace: gene_ontology
id: positively_regulates_characteristic
shorthand: positively_regulates_characteristic

negatively regulates characteristic
database_cross_reference: RO:0019002
has_obo_namespace: gene_ontology
id: negatively_regulates_characteristic
shorthand: negatively_regulates_characteristic

results in changes to anatomical or cellular structure
database_cross_reference: RO:0040036
has_obo_namespace: external
id: results_in_changes_to_anatomical_or_cellular_structure
shorthand: results_in_changes_to_anatomical_or_cellular_structure