---
layout: rule
id: GORULE:0000050
title: "Annotations to ISS, ISA and ISO should not be self-referential"
type: report
fail_mode: soft
status: implemented
contact: "go-quality@lists.stanford.edu"
implementations:
  - language: python
    source: https://github.com/biolink/ontobio/blob/master/ontobio/io/qc.py
---

Annotations to ISS, ISA and ISO should not have the same identifier in the 'gene product column' (column 2) and in the 'with/from' column (column 8).