goslim synapse.owl
type: Ontology
version IRI: goslim synapse.owl
version info: 2024-07-19

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

neurotransmitter uptake
type: Class
definition: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
has_broad_synonym: neurotransmitter recycling
has_exact_synonym: neurotransmitter import
has_narrow_synonym: neurotransmitter import into glial cell
has_narrow_synonym: neurotransmitter import into neuron
has_obo_namespace: biological_process
id: GO:0001504
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter uptake
annotated property: definition
annotated target: The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
database_cross_reference: ISBN:0123668387

Axiom
annotated source: neurotransmitter uptake
annotated property: has_exact_synonym
annotated target: neurotransmitter import
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

chemical synaptic transmission
type: Class
subclass of: trans-synaptic signaling
definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
has_broad_synonym: signal transmission across a synapse
has_broad_synonym: synaptic transmission
database_cross_reference: Wikipedia:Neurotransmission
has_obo_namespace: biological_process
has_related_synonym: neurotransmission
id: GO:0007268
in_subset: goslim synapse

Axiom
annotated source: chemical synaptic transmission
annotated property: definition
annotated target: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
database_cross_reference: GOC:jl
database_cross_reference: MeSH:D009435

Axiom
annotated source: chemical synaptic transmission
annotated property: has_related_synonym
annotated target: neurotransmission
database_cross_reference: GOC:dph

neurotransmitter secretion
type: Class
subclass of: signal release from synapse
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
has_alternative_id: GO:0010554
has_exact_synonym: neurotransmitter release
has_exact_synonym: neurotransmitter secretory pathway
has_obo_namespace: biological_process
id: GO:0007269
in_subset: goslim synapse
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.

Axiom
annotated source: neurotransmitter secretion
annotated property: definition
annotated target: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
database_cross_reference: GOC:dph

synapse assembly
type: Class
subclass of: synapse organization
definition: The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
database_cross_reference: Wikipedia:Synaptogenesis
has_exact_synonym: synapse biogenesis
has_exact_synonym: synaptogenesis
has_obo_namespace: biological_process
id: GO:0007416
in_subset: goslim synapse

Axiom
annotated source: synapse assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
database_cross_reference: GOC:mah

Axiom
annotated source: synapse assembly
annotated property: has_exact_synonym
annotated target: synapse biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: synapse assembly
annotated property: has_exact_synonym
annotated target: synaptogenesis
database_cross_reference: GOC:mah

synaptic vesicle
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
database_cross_reference: NIF_Subcellular:sao1071221672
database_cross_reference: Wikipedia:Synaptic_vesicle
has_narrow_synonym: docked vesicle
has_obo_namespace: cellular_component
id: GO:0008021
in_subset: goslim synapse
comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.

Axiom
annotated source: synaptic vesicle
annotated property: definition
annotated target: A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
database_cross_reference: PMID:10099709
database_cross_reference: PMID:12563290

Axiom
annotated source: synaptic vesicle
annotated property: has_narrow_synonym
annotated target: docked vesicle
database_cross_reference: NIF_Subcellular:sao403156667

synaptic target recognition
type: Class
definition: The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
has_exact_synonym: neuronal targeting
has_obo_namespace: biological_process
id: GO:0008039
in_subset: goslim synapse

Axiom
annotated source: synaptic target recognition
annotated property: definition
annotated target: The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0878932437

axo-dendritic transport
type: Class
definition: The directed movement of organelles or molecules along microtubules in neuron projections.
database_cross_reference: Wikipedia:Axoplasmic_transport
has_narrow_synonym: axon cargo transport
has_narrow_synonym: axonal transport
has_narrow_synonym: axoplasmic transport
has_obo_namespace: biological_process
id: GO:0008088
in_subset: goslim synapse

Axiom
annotated source: axo-dendritic transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules in neuron projections.
database_cross_reference: ISBN:0815316194

anterograde axonal transport
type: Class
subclass of: axonal transport
definition: The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
has_exact_synonym: anterograde axon cargo transport
has_obo_namespace: biological_process
id: GO:0008089
in_subset: goslim synapse

Axiom
annotated source: anterograde axonal transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
database_cross_reference: ISBN:0815316194

retrograde axonal transport
type: Class
subclass of: axonal transport
definition: The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
has_exact_synonym: retrograde axon cargo transport
has_obo_namespace: biological_process
id: GO:0008090
in_subset: goslim synapse

Axiom
annotated source: retrograde axonal transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
database_cross_reference: ISBN:0815316194

regulation of synaptic vesicle priming
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle priming
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
has_obo_namespace: biological_process
id: GO:0010807
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle priming
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
database_cross_reference: GOC:dph
database_cross_reference: GOC:kmv
database_cross_reference: GOC:tb
database_cross_reference: PMID:15489511

postsynaptic density
type: Class
subclass of: postsynaptic specialization
definition: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
created by: pr
creation date: 2013-07-02T09:44:28Z
has_alternative_id: GO:0097481
has_alternative_id: GO:0097483
database_cross_reference: NIF_Subcellular:sao1196688972
database_cross_reference: Wikipedia:Postsynaptic_density
has_exact_synonym: neuronal postsynaptic density
has_exact_synonym: post synaptic density
has_exact_synonym: post-synaptic density
has_narrow_synonym: postsynaptic density of dendrite
has_obo_namespace: cellular_component
id: GO:0014069
in_subset: goslim synapse

Axiom
annotated source: postsynaptic density
annotated property: definition
annotated target: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dos
database_cross_reference: GOC:ef
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr
database_cross_reference: GOC:sjp
database_cross_reference: PMID:14532281
database_cross_reference: Wikipedia:Postsynaptic_density

Axiom
annotated source: postsynaptic density
annotated property: has_exact_synonym
annotated target: neuronal postsynaptic density
database_cross_reference: GO:0097481

synaptic vesicle exocytosis
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: signal release from synapse
subclass of: Restriction
  on property: part of
  some values from: neurotransmitter secretion
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
has_obo_namespace: biological_process
id: GO:0016079
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle exocytosis
annotated property: definition
annotated target: Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
database_cross_reference: GOC:jid
database_cross_reference: GOC:lmg

synaptic vesicle docking
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle exocytosis
definition: The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
has_exact_synonym: synaptic vesicle docking involved in exocytosis
has_obo_namespace: biological_process
has_related_synonym: synaptic vesicle docking during exocytosis
id: GO:0016081
in_subset: goslim synapse
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015).

Axiom
annotated source: synaptic vesicle docking
annotated property: definition
annotated target: The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
database_cross_reference: PMID:15217342

Axiom
annotated source: synaptic vesicle docking
annotated property: has_related_synonym
annotated target: synaptic vesicle docking during exocytosis
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

synaptic vesicle priming
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle exocytosis
definition: A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
has_obo_namespace: biological_process
id: GO:0016082
in_subset: goslim synapse
comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)

Axiom
annotated source: synaptic vesicle priming
annotated property: definition
annotated target: A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
database_cross_reference: GOC:mah
database_cross_reference: PMID:15217342
database_cross_reference: PMID:23060190

synaptic vesicle budding from endosome
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle recycling via endosome
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle transport
definition: Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
has_exact_synonym: synaptic vesicle budding involved in synaptic vesicle exocytosis
has_obo_namespace: biological_process
has_related_synonym: endosome to synaptic vesicle budding
id: GO:0016182
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle budding from endosome
annotated property: definition
annotated target: Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
database_cross_reference: GOC:curators
database_cross_reference: PMID:10099709
database_cross_reference: PMID:24596248

Axiom
annotated source: synaptic vesicle budding from endosome
annotated property: has_exact_synonym
annotated target: synaptic vesicle budding involved in synaptic vesicle exocytosis
database_cross_reference: GOC:mah

Axiom
annotated source: synaptic vesicle budding from endosome
annotated property: has_related_synonym
annotated target: endosome to synaptic vesicle budding
database_cross_reference: GOC:mah

synaptic vesicle coating
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle budding from presynaptic endocytic zone membrane
definition: The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
has_obo_namespace: biological_process
id: GO:0016183
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle coating
annotated property: definition
annotated target: The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
database_cross_reference: GOC:curators
database_cross_reference: PMID:10099709
database_cross_reference: PMID:20448150

synaptic vesicle budding from presynaptic endocytic zone membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle endocytosis
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle transport
definition: Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
has_exact_synonym: synaptic vesicle budding from pre-synaptic membrane
has_exact_synonym: synaptic vesicle budding involved in synaptic vesicle endocytosis
has_obo_namespace: biological_process
id: GO:0016185
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle budding from presynaptic endocytic zone membrane
annotated property: definition
annotated target: Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
database_cross_reference: GOC:curators
database_cross_reference: PMID:10099709
database_cross_reference: PMID:20448150

Axiom
annotated source: synaptic vesicle budding from presynaptic endocytic zone membrane
annotated property: has_exact_synonym
annotated target: synaptic vesicle budding involved in synaptic vesicle endocytosis
database_cross_reference: GOC:mah

synaptic vesicle to endosome fusion
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle endosomal processing
definition: Fusion of a synaptic vesicle with an endosome.
has_obo_namespace: biological_process
id: GO:0016189
in_subset: goslim synapse
comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.

Axiom
annotated source: synaptic vesicle to endosome fusion
annotated property: definition
annotated target: Fusion of a synaptic vesicle with an endosome.
database_cross_reference: GOC:curators
database_cross_reference: PMID:10099709

synaptic vesicle uncoating
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle endocytosis
definition: The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.
has_exact_synonym: synaptic vesicle coat depolymerization
has_exact_synonym: synaptic vesicle coat protein depolymerization
has_obo_namespace: biological_process
id: GO:0016191
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle uncoating
annotated property: definition
annotated target: The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.
database_cross_reference: GOC:curators
database_cross_reference: PMID:10099709
database_cross_reference: PMID:24596248

axonal transport of mitochondrion
type: Class
subclass of: axonal transport
definition: The directed movement of mitochondria along microtubules in nerve cell axons.
has_exact_synonym: axon transport of mitochondria
has_obo_namespace: biological_process
id: GO:0019896
in_subset: goslim synapse

Axiom
annotated source: axonal transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in nerve cell axons.
database_cross_reference: GOC:ai

synaptic vesicle membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle
definition: The lipid bilayer surrounding a synaptic vesicle.
has_obo_namespace: cellular_component
id: GO:0030672
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a synaptic vesicle.
database_cross_reference: GOC:mah

synaptic vesicle fusion to presynaptic active zone membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle exocytosis
definition: Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
has_broad_synonym: synaptic vesicle fusion
has_exact_synonym: synaptic vesicle fusion to pre-synaptic membrane
has_exact_synonym: synaptic vesicle fusion to presynaptic membrane
has_obo_namespace: biological_process
id: GO:0031629
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle fusion to presynaptic active zone membrane
annotated property: definition
annotated target: Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: ISBN:0071120009
database_cross_reference: PMID:18618940

regulation of synaptic vesicle fusion to presynaptic active zone membrane
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle fusion to presynaptic active zone membrane
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
has_exact_synonym: regulation of synaptic vesicle fusion to pre-synaptic membrane
has_exact_synonym: regulation of synaptic vesicle fusion to presynaptic membrane
has_obo_namespace: biological_process
id: GO:0031630
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle fusion to presynaptic active zone membrane
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
database_cross_reference: GOC:mah

synaptic vesicle lumen
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle
definition: The volume enclosed by the synaptic vesicle membrane.
has_obo_namespace: cellular_component
id: GO:0034592
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle lumen
annotated property: definition
annotated target: The volume enclosed by the synaptic vesicle membrane.
database_cross_reference: GOC:rph

synaptic vesicle recycling via endosome
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle endosomal processing
definition: Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
created by: bf
creation date: 2014-06-26T11:07:46Z
has_alternative_id: GO:0099090
has_exact_synonym: recycling endosome localization within postsynapse
has_obo_namespace: biological_process
id: GO:0036466
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle recycling via endosome
annotated property: definition
annotated target: Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:bf
database_cross_reference: GOC:dos
database_cross_reference: GOC:pad
database_cross_reference: PMID:15217342

presynaptic membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
has_exact_synonym: pre-synaptic membrane
has_exact_synonym: presynaptic plasma membrane
has_obo_namespace: cellular_component
id: GO:0042734
in_subset: goslim synapse

Axiom
annotated source: presynaptic membrane
annotated property: definition
annotated target: A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0815316194

synaptic cleft
type: Class
definition: The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
database_cross_reference: NIF_Subcellular:sao243541954
has_obo_namespace: cellular_component
id: GO:0043083
in_subset: goslim synapse

Axiom
annotated source: synaptic cleft
annotated property: definition
annotated target: The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
database_cross_reference: GOC:jl
database_cross_reference: PMID:30784960

dendritic spine
type: Class
subclass of: postsynapse
definition: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
database_cross_reference: NIF_Subcellular:sao1799103720
database_cross_reference: Wikipedia:Dendritic_spine
has_exact_synonym: dendrite spine
has_narrow_synonym: branched dendritic spine
has_narrow_synonym: mushroom dendritic spine
has_narrow_synonym: sessile dendritic spine
has_narrow_synonym: stubby dendritic spine
has_narrow_synonym: thin dendritic spine
has_obo_namespace: cellular_component
id: GO:0043197
in_subset: goslim synapse

Axiom
annotated source: dendritic spine
annotated property: definition
annotated target: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
database_cross_reference: GOC:nln

Axiom
annotated source: dendritic spine
annotated property: has_narrow_synonym
annotated target: branched dendritic spine
database_cross_reference: NIF_Subcellular:sao965204139

Axiom
annotated source: dendritic spine
annotated property: has_narrow_synonym
annotated target: mushroom dendritic spine
database_cross_reference: NIF_Subcellular:sao876577163

Axiom
annotated source: dendritic spine
annotated property: has_narrow_synonym
annotated target: sessile dendritic spine
database_cross_reference: NIF_Subcellular:sao1536532595

Axiom
annotated source: dendritic spine
annotated property: has_narrow_synonym
annotated target: stubby dendritic spine
database_cross_reference: NIF_Subcellular:sao317384566

Axiom
annotated source: dendritic spine
annotated property: has_narrow_synonym
annotated target: thin dendritic spine
database_cross_reference: NIF_Subcellular:sao1232858786

synapse
type: Class
definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: NIF_Subcellular:sao914572699
database_cross_reference: Wikipedia:Chemical_synapse
has_exact_synonym: synaptic junction
has_narrow_synonym: mixed synapse
has_obo_namespace: cellular_component
has_related_synonym: electrotonic synapse
id: GO:0045202
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim synapse

Axiom
annotated source: synapse
annotated property: definition
annotated target: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: GOC:aruk
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:24619342
database_cross_reference: PMID:29383328
database_cross_reference: PMID:31998110

Axiom
annotated source: synapse
annotated property: has_narrow_synonym
annotated target: mixed synapse
database_cross_reference: NIF_Subcellular:sao1506103497

Axiom
annotated source: synapse
annotated property: has_related_synonym
annotated target: electrotonic synapse
database_cross_reference: NIF_Subcellular:sao1311109124

postsynaptic membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
has_exact_synonym: post-synaptic membrane
has_obo_namespace: cellular_component
id: GO:0045211
in_subset: goslim synapse

Axiom
annotated source: postsynaptic membrane
annotated property: definition
annotated target: A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: ISBN:0198506732

synaptic vesicle endocytosis
type: Class
subclass of: presynaptic endocytosis
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
definition: A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
term tracker item: https://github.com/geneontology/synapse/issues/230
has_alternative_id: GO:0008099
has_obo_namespace: biological_process
has_related_synonym: synaptic vesicle retrieval
id: GO:0048488
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle endocytosis
annotated property: definition
annotated target: A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:jid
database_cross_reference: GOC:lmg
database_cross_reference: GOC:mah
database_cross_reference: PMID:20448150
database_cross_reference: PMID:26430111

synaptic vesicle transport
type: Class
definition: The directed movement of synaptic vesicles.
has_alternative_id: GO:0016181
has_obo_namespace: biological_process
has_related_synonym: synaptic vesicle fission
has_related_synonym: synaptic vesicle fusion
has_related_synonym: synaptic vesicle trafficking
id: GO:0048489
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle transport
annotated property: definition
annotated target: The directed movement of synaptic vesicles.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:jid
database_cross_reference: GOC:lmg
database_cross_reference: GOC:pr

Axiom
annotated source: synaptic vesicle transport
annotated property: has_related_synonym
annotated target: synaptic vesicle trafficking
database_cross_reference: PMID:15217342

anterograde synaptic vesicle transport
type: Class
subclass of: anterograde axonal transport
subclass of: synaptic vesicle transport along microtubule
definition: The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
has_exact_synonym: anterograde axonal transport of synaptic vesicle
has_obo_namespace: biological_process
id: GO:0048490
in_subset: goslim synapse

Axiom
annotated source: anterograde synaptic vesicle transport
annotated property: definition
annotated target: The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
database_cross_reference: GOC:jid
database_cross_reference: GOC:lmg

retrograde synaptic vesicle transport
type: Class
subclass of: retrograde axonal transport
subclass of: synaptic vesicle transport along microtubule
definition: The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body.
has_exact_synonym: retrograde axonal transport of synaptic vesicle
has_obo_namespace: biological_process
id: GO:0048491
in_subset: goslim synapse

Axiom
annotated source: retrograde synaptic vesicle transport
annotated property: definition
annotated target: The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body.
database_cross_reference: GOC:jid
database_cross_reference: GOC:lmg
database_cross_reference: PMID:24762653

presynaptic active zone
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
database_cross_reference: NIF_Subcellular:sao792027222
has_exact_synonym: pre-synaptic active zone
has_exact_synonym: presynaptic specialization
has_narrow_synonym: pre-synaptic active zone component
has_obo_namespace: cellular_component
id: GO:0048786
in_subset: goslim synapse

Axiom
annotated source: presynaptic active zone
annotated property: definition
annotated target: A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
database_cross_reference: GOC:dh
database_cross_reference: GOC:dl
database_cross_reference: GOC:ef
database_cross_reference: GOC:jid
database_cross_reference: GOC:pr
database_cross_reference: PMID:3152289

Axiom
annotated source: presynaptic active zone
annotated property: has_narrow_synonym
annotated target: pre-synaptic active zone component
database_cross_reference: NIF_Subcellular:sao1911631652

presynaptic active zone membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic active zone
definition: The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
database_cross_reference: NIF_Subcellular:sao2038461087
has_exact_synonym: active zone plasma membrane
has_exact_synonym: active zone pre-synaptic plasma membrane
has_exact_synonym: active zone presynaptic plasma membrane
has_exact_synonym: pre-synaptic active zone membrane
has_obo_namespace: cellular_component
id: GO:0048787
in_subset: goslim synapse

Axiom
annotated source: presynaptic active zone membrane
annotated property: definition
annotated target: The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
database_cross_reference: PMID:12812759
database_cross_reference: PMID:12923177
database_cross_reference: PMID:3152289

Axiom
annotated source: presynaptic active zone membrane
annotated property: has_exact_synonym
annotated target: active zone plasma membrane
database_cross_reference: NIF_Subcellular:sao2038461087

maintenance of presynaptic active zone structure
type: Class
subclass of: maintenance of synapse structure
subclass of: Restriction
  on property: part of
  some values from: synapse organization
definition: A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.
has_exact_synonym: maintenance of pre-synaptic active zone structure
has_obo_namespace: biological_process
id: GO:0048790
in_subset: goslim synapse

Axiom
annotated source: maintenance of presynaptic active zone structure
annotated property: definition
annotated target: A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:pr

modulation of chemical synaptic transmission
type: Class
subclass of: Restriction
  on property: regulates
  some values from: chemical synaptic transmission
definition: Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
has_broad_synonym: modulation of synaptic transmission
has_exact_synonym: regulation of chemical synaptic transmission
has_exact_synonym: regulation of synaptic transmission
has_obo_namespace: biological_process
id: GO:0050804
in_subset: goslim synapse

Axiom
annotated source: modulation of chemical synaptic transmission
annotated property: definition
annotated target: Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
database_cross_reference: GOC:ai

regulation of synapse organization
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synapse organization
definition: Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
has_exact_synonym: regulation of synapse organisation
has_exact_synonym: regulation of synapse structure
has_obo_namespace: biological_process
has_related_synonym: regulation of synapse organization and biogenesis
id: GO:0050807
in_subset: goslim synapse

Axiom
annotated source: regulation of synapse organization
annotated property: definition
annotated target: Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of synapse organization
annotated property: has_exact_synonym
annotated target: regulation of synapse organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of synapse organization
annotated property: has_related_synonym
annotated target: regulation of synapse organization and biogenesis
database_cross_reference: GOC:mah

synapse organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
has_exact_synonym: synapse organisation
has_obo_namespace: biological_process
has_related_synonym: synapse development
has_related_synonym: synapse morphogenesis
has_related_synonym: synapse organization and biogenesis
id: GO:0050808
in_subset: goslim drosophila
in_subset: goslim synapse

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: synapse organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
database_cross_reference: GOC:ai
database_cross_reference: GOC:pr

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse development
database_cross_reference: GOC:aruk

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse morphogenesis
database_cross_reference: GOC:BHF

regulation of neurotransmitter uptake
type: Class
subclass of: Restriction
  on property: regulates
  some values from: neurotransmitter uptake
definition: Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
has_exact_synonym: regulation of neurotransmitter import
has_exact_synonym: regulation of neurotransmitter reuptake
has_obo_namespace: biological_process
id: GO:0051580
in_subset: goslim synapse

Axiom
annotated source: regulation of neurotransmitter uptake
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
database_cross_reference: GOC:ai

Axiom
annotated source: regulation of neurotransmitter uptake
annotated property: has_exact_synonym
annotated target: regulation of neurotransmitter import
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of synapse assembly
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: synapse assembly
definition: Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
has_exact_synonym: regulation of synapse biogenesis
has_exact_synonym: regulation of synaptogenesis
has_obo_namespace: biological_process
id: GO:0051963
in_subset: goslim synapse

Axiom
annotated source: regulation of synapse assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
database_cross_reference: GOC:ai
database_cross_reference: GOC:pr

synapse maturation
type: Class
subclass of: synapse organization
definition: The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
has_exact_synonym: synaptic maturation
has_obo_namespace: biological_process
id: GO:0060074
in_subset: goslim synapse

Axiom
annotated source: synapse maturation
annotated property: definition
annotated target: The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ef

regulation of postsynaptic membrane potential
type: Class
definition: Any process that modulates the potential difference across a post-synaptic membrane.
has_exact_synonym: regulation of post-synaptic membrane potential
has_obo_namespace: biological_process
id: GO:0060078
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any process that modulates the potential difference across a post-synaptic membrane.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ef

regulation of synapse maturation
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: synapse maturation
definition: Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
created by: tb
creation date: 2009-12-07T03:00:58Z
has_obo_namespace: biological_process
id: GO:0090128
in_subset: goslim synapse

Axiom
annotated source: regulation of synapse maturation
annotated property: definition
annotated target: Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

synaptic membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse
definition: A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
created by: pr
creation date: 2011-06-07T11:22:09Z
has_obo_namespace: cellular_component
id: GO:0097060
in_subset: goslim synapse

Axiom
annotated source: synaptic membrane
annotated property: definition
annotated target: A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
database_cross_reference: GOC:BHF
database_cross_reference: PMID:20410104

synaptic vesicle clustering
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
definition: The process that results in grouping synaptic vesicles in presynaptic structures.
term tracker item: https://github.com/geneontology/synapse/issues/163
created by: pr
creation date: 2011-07-04T01:48:24Z
has_obo_namespace: biological_process
id: GO:0097091
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle clustering
annotated property: definition
annotated target: The process that results in grouping synaptic vesicles in presynaptic structures.
database_cross_reference: GOC:ans
database_cross_reference: GOC:pr
database_cross_reference: PMID:19900895
database_cross_reference: PMID:7568108

postsynaptic membrane assembly
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse assembly
subclass of: Restriction
  on property: part of
  some values from: postsynapse organization
definition: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
created by: pr
creation date: 2011-07-27T01:26:49Z
has_exact_synonym: post-synaptic membrane assembly
has_obo_namespace: biological_process
id: GO:0097104
in_subset: goslim synapse

Axiom
annotated source: postsynaptic membrane assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
database_cross_reference: GOC:BHF
database_cross_reference: GOC:sjp
database_cross_reference: PMID:21424692

presynaptic membrane assembly
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse assembly
definition: The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
created by: pr
creation date: 2011-07-27T01:30:45Z
has_exact_synonym: pre-synaptic membrane assembly
has_obo_namespace: biological_process
id: GO:0097105
in_subset: goslim synapse
comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.

Axiom
annotated source: presynaptic membrane assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:pr
database_cross_reference: GOC:sjp
database_cross_reference: PMID:15797875
database_cross_reference: PMID:18550748

postsynaptic density assembly
type: Class
subclass of: postsynaptic specialization assembly
definition: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
created by: pr
creation date: 2011-07-27T05:21:39Z
has_exact_synonym: PSD assembly
has_exact_synonym: post synaptic density assembly
has_exact_synonym: post-synaptic density assembly
has_obo_namespace: biological_process
id: GO:0097107
in_subset: goslim synapse

Axiom
annotated source: postsynaptic density assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:sjp
database_cross_reference: PMID:21525273

synaptic vesicle lumen acidification
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
definition: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
created by: pr
creation date: 2012-10-25T09:03:34Z
has_exact_synonym: synaptic vesicle lumen pH reduction
has_exact_synonym: synaptic vesicle proton loading
has_obo_namespace: biological_process
id: GO:0097401
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle lumen acidification
annotated property: definition
annotated target: The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
database_cross_reference: GOC:dsf
database_cross_reference: PMID:21172605
database_cross_reference: PMID:22875945

Axiom
annotated source: synaptic vesicle lumen acidification
annotated property: has_exact_synonym
annotated target: synaptic vesicle proton loading
has_synonym_type: label approved by the SynGO project

spine apparatus
type: Class
subclass of: Restriction
  on property: part of
  some values from: dendritic spine
definition: A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
created by: pr
creation date: 2012-12-06T14:05:58Z
database_cross_reference: NIF_Subcellular:sao725931194
has_narrow_synonym: dense material
has_obo_namespace: cellular_component
id: GO:0097444
in_subset: goslim synapse

Axiom
annotated source: spine apparatus
annotated property: definition
annotated target: A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
database_cross_reference: NIF_Subcellular:sao725931194
database_cross_reference: PMID:20400711
database_cross_reference: PMID:8987748

Axiom
annotated source: spine apparatus
annotated property: has_narrow_synonym
annotated target: dense material
database_cross_reference: NIF_Subcellular:sao1004601938

mossy fiber rosette
type: Class
subclass of: synapse
subclass of: Restriction
  on property: has part
  some values from: postsynaptic density
definition: A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.
created by: pr
creation date: 2013-02-21T07:42:52Z
database_cross_reference: NIF_Subcellular:nlx_subcell_091021
has_exact_synonym: cerebellar mossy fiber to granule cell synapse
has_obo_namespace: cellular_component
id: GO:0097471
in_subset: goslim synapse

Axiom
annotated source: mossy fiber rosette
annotated property: definition
annotated target: A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.
database_cross_reference: NIF_Subcellular:nlx_subcell_091021
database_cross_reference: Wikipedia:Mossy_fiber_(cerebellum)

Axiom
annotated source: mossy fiber rosette
annotated property: has_exact_synonym
annotated target: cerebellar mossy fiber to granule cell synapse
has_synonym_type: label approved by the SynGO project

extrinsic component of neuronal dense core vesicle membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: neuronal dense core vesicle membrane
definition: The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
created by: dos
creation date: 2017-01-17T16:20:56Z
has_obo_namespace: cellular_component
id: GO:0098674
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of neuronal dense core vesicle membrane
annotated property: definition
annotated target: The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:dos

cochlear hair cell ribbon synapse
type: Class
subclass of: synapse
definition: A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.
created by: dos
creation date: 2017-02-05T16:16:49Z
has_obo_namespace: cellular_component
id: GO:0098683
in_subset: goslim synapse

Axiom
annotated source: cochlear hair cell ribbon synapse
annotated property: definition
annotated target: A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.
database_cross_reference: PMID:15626493

photoreceptor ribbon synapse
type: Class
subclass of: synapse
definition: A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
created by: dos
creation date: 2017-02-05T16:26:27Z
has_obo_namespace: cellular_component
id: GO:0098684
in_subset: goslim synapse

Axiom
annotated source: photoreceptor ribbon synapse
annotated property: definition
annotated target: A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
database_cross_reference: PMID:15626493

Schaffer collateral - CA1 synapse
type: Class
subclass of: synapse
definition: A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
created by: dos
creation date: 2017-02-05T16:29:43Z
has_obo_namespace: cellular_component
id: GO:0098685
in_subset: goslim synapse

Axiom
annotated source: Schaffer collateral - CA1 synapse
annotated property: definition
annotated target: A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
database_cross_reference: PMID:16399689

hippocampal mossy fiber to CA3 synapse
type: Class
subclass of: synapse
subclass of: Restriction
  on property: has part
  some values from: dendritic spine
subclass of: Restriction
  on property: has part
  some values from: presynapse
definition: One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
created by: dos
creation date: 2017-02-05T16:29:58Z
has_obo_namespace: cellular_component
id: GO:0098686
in_subset: goslim synapse

Axiom
annotated source: hippocampal mossy fiber to CA3 synapse
annotated property: definition
annotated target: One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
database_cross_reference: DOI:10.1002/1096-9861
database_cross_reference: PMID:13869693
database_cross_reference: PMID:23264762

parallel fiber to Purkinje cell synapse
type: Class
subclass of: synapse
definition: An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
created by: dos
creation date: 2017-02-21T18:32:05Z
has_obo_namespace: cellular_component
id: GO:0098688
in_subset: goslim synapse

Axiom
annotated source: parallel fiber to Purkinje cell synapse
annotated property: definition
annotated target: An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
database_cross_reference: PMID:16623829
database_cross_reference: PMID:3209740

glycinergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses glycine as a neurotransmitter.
created by: dos
creation date: 2017-03-07T14:50:33Z
has_obo_namespace: cellular_component
id: GO:0098690
in_subset: goslim synapse

Axiom
annotated source: glycinergic synapse
annotated property: definition
annotated target: A synapse that uses glycine as a neurotransmitter.
database_cross_reference: GOC:dos

dopaminergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses dopamine as a neurotransmitter.
created by: dos
creation date: 2017-03-07T14:51:52Z
has_obo_namespace: cellular_component
id: GO:0098691
in_subset: goslim synapse

Axiom
annotated source: dopaminergic synapse
annotated property: definition
annotated target: A synapse that uses dopamine as a neurotransmitter.
database_cross_reference: GOC:dos

regulation of synaptic vesicle cycle
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle cycle
definition: Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
created by: dos
creation date: 2017-03-21T16:06:48Z
has_obo_namespace: biological_process
id: GO:0098693
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle cycle
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
database_cross_reference: GOC:dos

regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle budding from presynaptic endocytic zone membrane
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.
created by: dos
creation date: 2017-04-04T17:03:29Z
has_obo_namespace: biological_process
id: GO:0098694
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.
database_cross_reference: GOC:dos

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
definition: Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2017-04-04T17:07:09Z
has_exact_synonym: IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:0098695
in_subset: goslim synapse

Axiom
annotated source: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: definition
annotated target: Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:dos

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
type: Class
subclass of: Restriction
  on property: regulates
  some values from: neurotransmitter receptor localization to postsynaptic specialization membrane
definition: Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
created by: dos
creation date: 2017-04-04T16:33:38Z
has_obo_namespace: biological_process
id: GO:0098696
in_subset: goslim synapse

Axiom
annotated source: regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
database_cross_reference: GOC:dos

ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
type: Class
subclass of: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
definition: Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2017-04-04T17:11:38Z
has_obo_namespace: molecular_function
id: GO:0098697
in_subset: goslim synapse

Axiom
annotated source: ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: definition
annotated target: Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:dos

postsynaptic specialization assembly
type: Class
subclass of: postsynaptic specialization organization
subclass of: Restriction
  on property: part of
  some values from: synapse assembly
definition: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
created by: dos
creation date: 2017-04-04T17:22:01Z
has_obo_namespace: biological_process
id: GO:0098698
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
database_cross_reference: GOC:dos

structural constituent of presynaptic actin cytoskeleton
type: Class
subclass of: structural constituent of presynapse
subclass of: Restriction
  on property: part of
  some values from: presynaptic actin cytoskeleton organization
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic actin cytoskeleton
definition: The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton.
created by: dos
creation date: 2017-06-09T18:33:07Z
has_obo_namespace: molecular_function
id: GO:0098699
in_subset: goslim synapse

Axiom
annotated source: structural constituent of presynaptic actin cytoskeleton
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton.
database_cross_reference: GOC:dos

neurotransmitter loading into synaptic vesicle
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle cycle
definition: The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.
has_exact_synonym: neurotransmitter import into synaptic vesicle
has_exact_synonym: neurotransmitter uptake into synaptic vesicle
has_exact_synonym: synaptic vesicle neurotransmitter loading
has_obo_namespace: biological_process
id: GO:0098700
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter loading into synaptic vesicle
annotated property: definition
annotated target: The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:bf
database_cross_reference: GOC:pad
database_cross_reference: PMID:10099709
database_cross_reference: PMID:15217342

Axiom
annotated source: neurotransmitter loading into synaptic vesicle
annotated property: has_exact_synonym
annotated target: neurotransmitter uptake into synaptic vesicle
database_cross_reference: PMID:15217342

Axiom
annotated source: neurotransmitter loading into synaptic vesicle
annotated property: has_exact_synonym
annotated target: synaptic vesicle neurotransmitter loading
has_synonym_type: label approved by the SynGO project

presynapse
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse
definition: The part of a synapse that is part of the presynaptic cell.
has_exact_synonym: presynaptic terminal
has_obo_namespace: cellular_component
id: GO:0098793
in_subset: goslim synapse

Axiom
annotated source: presynapse
annotated property: definition
annotated target: The part of a synapse that is part of the presynaptic cell.
database_cross_reference: GOC:dos

postsynapse
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse
definition: The part of a synapse that is part of the post-synaptic cell.
has_obo_namespace: cellular_component
id: GO:0098794
in_subset: goslim synapse

Axiom
annotated source: postsynapse
annotated property: definition
annotated target: The part of a synapse that is part of the post-synaptic cell.
database_cross_reference: GOC:dos

neurotransmitter reuptake
type: Class
subclass of: neurotransmitter uptake
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0098810
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter reuptake
annotated property: definition
annotated target: The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.
database_cross_reference: GOC:dos

spontaneous synaptic transmission
type: Class
subclass of: chemical synaptic transmission
subclass of: Restriction
  on property: has part
  some values from: neurotransmitter secretion
definition: The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
has_exact_synonym: basal synaptic transmission
has_obo_namespace: biological_process
id: GO:0098814
in_subset: goslim synapse
comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).

Axiom
annotated source: spontaneous synaptic transmission
annotated property: definition
annotated target: The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
database_cross_reference: PMID:20200227

Axiom
annotated source: spontaneous synaptic transmission
annotated property: has_exact_synonym
annotated target: basal synaptic transmission
database_cross_reference: PMID:16899074

trans-synaptic protein complex
type: Class
definition: A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.
has_obo_namespace: cellular_component
id: GO:0098820
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic protein complex
annotated property: definition
annotated target: A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.
database_cross_reference: PMID:20200227

presynaptic endosome
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
has_obo_namespace: cellular_component
id: GO:0098830
in_subset: goslim synapse
comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details.

Axiom
annotated source: presynaptic endosome
annotated property: definition
annotated target: An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
database_cross_reference: PMID:20200227
database_cross_reference: PMID:25939282

presynaptic active zone cytoplasmic component
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynaptic active zone
definition: A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
has_exact_synonym: cortex of presynaptic active zone
has_exact_synonym: presynaptic zone cortex
has_obo_namespace: cellular_component
id: GO:0098831
in_subset: goslim synapse

Axiom
annotated source: presynaptic active zone cytoplasmic component
annotated property: definition
annotated target: A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
database_cross_reference: GOC:dos

presynaptic endocytic zone
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
has_obo_namespace: cellular_component
id: GO:0098833
in_subset: goslim synapse
comment: May be identical to periactive zone?

Axiom
annotated source: presynaptic endocytic zone
annotated property: definition
annotated target: A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
database_cross_reference: PMID:17455288

presynaptic endocytic zone cytoplasmic component
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynaptic endocytic zone
definition: The cytoplasmic component of the presynaptic endocytic zone.
has_exact_synonym: cortex of presynaptic endocytic zone
has_obo_namespace: cellular_component
id: GO:0098834
in_subset: goslim synapse

Axiom
annotated source: presynaptic endocytic zone cytoplasmic component
annotated property: definition
annotated target: The cytoplasmic component of the presynaptic endocytic zone.
database_cross_reference: GOC:dos

presynaptic endocytic zone membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic endocytic zone
definition: The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release.
has_obo_namespace: cellular_component
id: GO:0098835
in_subset: goslim synapse

Axiom
annotated source: presynaptic endocytic zone membrane
annotated property: definition
annotated target: The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release.
database_cross_reference: GOC:dos

postsynaptic recycling endosome
type: Class
subclass of: postsynaptic endosome
definition: A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.
has_broad_synonym: postsynaptic endosomal recycling compartment
has_exact_synonym: postsynaptic recycling outpost
has_obo_namespace: cellular_component
id: GO:0098837
in_subset: goslim synapse

Axiom
annotated source: postsynaptic recycling endosome
annotated property: definition
annotated target: A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.
database_cross_reference: PMID:20820847

Axiom
annotated source: postsynaptic recycling endosome
annotated property: has_broad_synonym
annotated target: postsynaptic endosomal recycling compartment
database_cross_reference: PMID:20820847

Axiom
annotated source: postsynaptic recycling endosome
annotated property: has_exact_synonym
annotated target: postsynaptic recycling outpost
database_cross_reference: PMID:20820847

postsynaptic density membrane
type: Class
subclass of: postsynaptic specialization membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic density
definition: The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
has_obo_namespace: cellular_component
id: GO:0098839
in_subset: goslim synapse

Axiom
annotated source: postsynaptic density membrane
annotated property: definition
annotated target: The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
database_cross_reference: GOC:dos

postsynaptic early endosome
type: Class
subclass of: postsynaptic endosome
definition: An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
has_obo_namespace: cellular_component
id: GO:0098842
in_subset: goslim synapse
comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1.

Axiom
annotated source: postsynaptic early endosome
annotated property: definition
annotated target: An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
database_cross_reference: PMID:19603039
database_cross_reference: PMID:20820847
database_cross_reference: PMID:24727350

postsynaptic endocytic zone
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.
has_obo_namespace: cellular_component
id: GO:0098843
in_subset: goslim synapse

Axiom
annotated source: postsynaptic endocytic zone
annotated property: definition
annotated target: A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.
database_cross_reference: PMID:17880892

postsynaptic endocytic zone membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic endocytic zone
definition: The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.
has_obo_namespace: cellular_component
id: GO:0098844
in_subset: goslim synapse

Axiom
annotated source: postsynaptic endocytic zone membrane
annotated property: definition
annotated target: The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.
database_cross_reference: PMID:17880892

postsynaptic endosome
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.
has_obo_namespace: cellular_component
id: GO:0098845
in_subset: goslim synapse

Axiom
annotated source: postsynaptic endosome
annotated property: definition
annotated target: An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.
database_cross_reference: PMID:20820847

extrinsic component of synaptic vesicle membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle membrane
definition: The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098850
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of synaptic vesicle membrane
annotated property: definition
annotated target: The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:dos

postsynaptic actin cytoskeleton
type: Class
subclass of: postsynaptic cytoskeleton
definition: The actin cytoskeleton that is part of a postsynapse.
has_obo_namespace: cellular_component
id: GO:0098871
in_subset: goslim synapse

Axiom
annotated source: postsynaptic actin cytoskeleton
annotated property: definition
annotated target: The actin cytoskeleton that is part of a postsynapse.
database_cross_reference: GOC:dos

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
definition: A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.
has_exact_synonym: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:0098872
in_subset: goslim synapse

Axiom
annotated source: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.
database_cross_reference: GOC:dos

Axiom
annotated source: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

neurotransmitter receptor transport to plasma membrane
type: Class
subclass of: neurotransmitter receptor transport
definition: The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.
has_obo_namespace: biological_process
id: GO:0098877
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport to plasma membrane
annotated property: definition
annotated target: The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.
database_cross_reference: GOC:dos

structural constituent of postsynaptic specialization
type: Class
subclass of: structural constituent of postsynapse
subclass of: Restriction
  on property: part of
  some values from: maintenance of postsynaptic specialization structure
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic specialization
definition: The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
has_obo_namespace: molecular_function
id: GO:0098879
in_subset: goslim synapse

Axiom
annotated source: structural constituent of postsynaptic specialization
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
database_cross_reference: GOC:dos

maintenance of postsynaptic specialization structure
type: Class
subclass of: postsynaptic specialization organization
subclass of: maintenance of synapse structure
definition: A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
has_obo_namespace: biological_process
id: GO:0098880
in_subset: goslim synapse

Axiom
annotated source: maintenance of postsynaptic specialization structure
annotated property: definition
annotated target: A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
database_cross_reference: GOC:dos

exocytic insertion of neurotransmitter receptor to plasma membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: neurotransmitter receptor transport to plasma membrane
definition: The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.
has_exact_synonym: neurotransmitter receptor insertion
has_obo_namespace: biological_process
id: GO:0098881
in_subset: goslim synapse

Axiom
annotated source: exocytic insertion of neurotransmitter receptor to plasma membrane
annotated property: definition
annotated target: The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:19503082

structural constituent of presynaptic active zone
type: Class
subclass of: structural constituent of synapse
subclass of: Restriction
  on property: part of
  some values from: maintenance of presynaptic active zone structure
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic active zone
definition: The action of a molecule that contributes to the structural integrity of a presynaptic active zone.
has_exact_synonym: structural constituent of active zone
has_obo_namespace: molecular_function
id: GO:0098882
in_subset: goslim synapse

Axiom
annotated source: structural constituent of presynaptic active zone
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a presynaptic active zone.
database_cross_reference: GOC:dos

Axiom
annotated source: structural constituent of presynaptic active zone
annotated property: has_exact_synonym
annotated target: structural constituent of active zone
has_synonym_type: label approved by the SynGO project

synapse pruning
type: Class
subclass of: synapse organization
definition: A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
has_exact_synonym: synapse clearance
has_exact_synonym: synapse disassembly
has_exact_synonym: synapse elimination
has_exact_synonym: synapse removal
has_obo_namespace: biological_process
id: GO:0098883
in_subset: goslim synapse

Axiom
annotated source: synapse pruning
annotated property: definition
annotated target: A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
database_cross_reference: GOC:dos
database_cross_reference: PMID:12062020
database_cross_reference: PMID:18083105
database_cross_reference: PMID:22632716
database_cross_reference: PMID:29844190

Axiom
annotated source: synapse pruning
annotated property: has_exact_synonym
annotated target: synapse clearance
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:22632716

Axiom
annotated source: synapse pruning
annotated property: has_exact_synonym
annotated target: synapse disassembly
database_cross_reference: PMID:12062020
has_synonym_type: label approved by the SynGO project

Axiom
annotated source: synapse pruning
annotated property: has_exact_synonym
annotated target: synapse elimination
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:18083105
database_cross_reference: PMID:29844190

Axiom
annotated source: synapse pruning
annotated property: has_exact_synonym
annotated target: synapse removal
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:22632716

postsynaptic neurotransmitter receptor internalization
type: Class
subclass of: regulation of postsynaptic membrane neurotransmitter receptor levels
subclass of: postsynaptic endocytosis
definition: A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
term tracker item: https://github.com/geneontology/synapse/issues/230
has_exact_synonym: postsynaptic neurotransmitter receptor endocytosis
has_obo_namespace: biological_process
id: GO:0098884
in_subset: goslim synapse

Axiom
annotated source: postsynaptic neurotransmitter receptor internalization
annotated property: definition
annotated target: A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
database_cross_reference: GOC:dos

Axiom
annotated source: postsynaptic neurotransmitter receptor internalization
annotated property: has_exact_synonym
annotated target: postsynaptic neurotransmitter receptor endocytosis
has_synonym_type: label approved by the SynGO project

modification of postsynaptic actin cytoskeleton
type: Class
subclass of: modification of postsynaptic structure
definition: Any process that modifies the structure of a postsynaptic actin cytoskeleton.
has_exact_synonym: postsynaptic actin cytoskeleton remodelling
has_obo_namespace: biological_process
id: GO:0098885
in_subset: goslim synapse
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.

Axiom
annotated source: modification of postsynaptic actin cytoskeleton
annotated property: definition
annotated target: Any process that modifies the structure of a postsynaptic actin cytoskeleton.
database_cross_reference: GOC:dos

neurotransmitter receptor transport, endosome to postsynaptic membrane
type: Class
subclass of: neurotransmitter receptor transport to postsynaptic membrane
subclass of: neurotransmitter receptor transport, endosome to plasma membrane
definition: The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
has_broad_synonym: postsynaptic neurotransmitter receptor endosomal trafficking
has_obo_namespace: biological_process
id: GO:0098887
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport, endosome to postsynaptic membrane
annotated property: definition
annotated target: The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
database_cross_reference: GOC:dos

extrinsic component of presynaptic membrane
type: Class
subclass of: extrinsic component of synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic membrane
definition: The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_exact_synonym: extrinsic component of presynaptic plasma membrane
has_obo_namespace: cellular_component
id: GO:0098888
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of presynaptic membrane
annotated property: definition
annotated target: The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of postsynaptic membrane
type: Class
subclass of: extrinsic component of synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic membrane
definition: The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098890
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic membrane
annotated property: definition
annotated target: The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of presynaptic active zone membrane
type: Class
subclass of: extrinsic component of presynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic active zone membrane
definition: The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098891
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of presynaptic active zone membrane
annotated property: definition
annotated target: The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of postsynaptic specialization membrane
type: Class
subclass of: extrinsic component of postsynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic specialization membrane
definition: The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098892
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic specialization membrane
annotated property: definition
annotated target: The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of postsynaptic endocytic zone
type: Class
subclass of: extrinsic component of postsynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic endocytic zone membrane
definition: The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098893
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic endocytic zone
annotated property: definition
annotated target: The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of presynaptic endocytic zone membrane
type: Class
subclass of: extrinsic component of presynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: presynaptic endocytic zone membrane
definition: The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098894
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of presynaptic endocytic zone membrane
annotated property: definition
annotated target: The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

postsynaptic endosome membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynaptic endosome
definition: The lipid bilayer surrounding a postsynaptic endosome.
has_obo_namespace: cellular_component
id: GO:0098895
in_subset: goslim synapse

Axiom
annotated source: postsynaptic endosome membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a postsynaptic endosome.
database_cross_reference: GOC:pz

postsynaptic early endosome membrane
type: Class
subclass of: postsynaptic endosome membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic early endosome
definition: The lipid bilayer surrounding a postsynaptic early endosome.
has_obo_namespace: cellular_component
id: GO:0098896
in_subset: goslim synapse

Axiom
annotated source: postsynaptic early endosome membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a postsynaptic early endosome.
database_cross_reference: GOC:pz

spine apparatus membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: spine apparatus
definition: The lipid bilayer surrounding the spine apparatus.
has_obo_namespace: cellular_component
id: GO:0098897
in_subset: goslim synapse

Axiom
annotated source: spine apparatus membrane
annotated property: definition
annotated target: The lipid bilayer surrounding the spine apparatus.
database_cross_reference: GOC:mah

spine apparatus lumen
type: Class
subclass of: Restriction
  on property: part of
  some values from: spine apparatus
definition: The volume enclosed by the spine apparatus membrane.
has_obo_namespace: cellular_component
id: GO:0098899
in_subset: goslim synapse

Axiom
annotated source: spine apparatus lumen
annotated property: definition
annotated target: The volume enclosed by the spine apparatus membrane.
database_cross_reference: GOC:dos

structural constituent of synapse
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse organization
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: The action of a molecule that contributes to the structural integrity of a synapse.
has_obo_namespace: molecular_function
id: GO:0098918
in_subset: goslim synapse

Axiom
annotated source: structural constituent of synapse
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a synapse.
database_cross_reference: GOC:dos

structural constituent of postsynaptic density
type: Class
subclass of: structural constituent of postsynaptic specialization
subclass of: Restriction
  on property: part of
  some values from: maintenance of postsynaptic density structure
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic density
definition: The action of a molecule that contributes to the structural integrity of a postsynaptic density.
has_obo_namespace: molecular_function
id: GO:0098919
in_subset: goslim synapse

Axiom
annotated source: structural constituent of postsynaptic density
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a postsynaptic density.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by lipid
type: Class
subclass of: trans-synaptic signaling by lipid
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.
has_obo_namespace: biological_process
id: GO:0098920
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by lipid
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by endocannabinoid
type: Class
subclass of: retrograde trans-synaptic signaling by lipid
subclass of: trans-synaptic signaling by endocannabinoid
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.
has_obo_namespace: biological_process
id: GO:0098921
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by endocannabinoid
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by soluble gas
type: Class
subclass of: trans-synaptic signaling by soluble gas
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand.
has_obo_namespace: biological_process
id: GO:0098923
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by soluble gas
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by nitric oxide
type: Class
subclass of: retrograde trans-synaptic signaling by soluble gas
subclass of: trans-synaptic signaling by nitric oxide
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
has_obo_namespace: biological_process
id: GO:0098924
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by nitric oxide
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
type: Class
subclass of: retrograde trans-synaptic signaling by nitric oxide
subclass of: trans-synaptic signaling by nitric oxide, modulating synaptic transmission
definition: Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
has_obo_namespace: biological_process
id: GO:0098925
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
annotated property: definition
annotated target: Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
database_cross_reference: GOC:dos

postsynaptic signal transduction
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic signaling
definition: Signal transduction in which the initial step occurs in a postsynapse.
has_exact_synonym: postsynaptic signaling pathway
has_obo_namespace: biological_process
id: GO:0098926
in_subset: goslim synapse

Axiom
annotated source: postsynaptic signal transduction
annotated property: definition
annotated target: Signal transduction in which the initial step occurs in a postsynapse.
database_cross_reference: GOC:dos

Axiom
annotated source: postsynaptic signal transduction
annotated property: has_exact_synonym
annotated target: postsynaptic signaling pathway
has_synonym_type: label approved by the SynGO project

presynaptic signal transduction
type: Class
definition: Signal transduction in which the initial step occurs in a presynapse.
has_exact_synonym: presynaptic signaling pathway
has_obo_namespace: biological_process
id: GO:0098928
in_subset: goslim synapse

Axiom
annotated source: presynaptic signal transduction
annotated property: definition
annotated target: Signal transduction in which the initial step occurs in a presynapse.
database_cross_reference: GOC:dos

Axiom
annotated source: presynaptic signal transduction
annotated property: has_exact_synonym
annotated target: presynaptic signaling pathway
has_synonym_type: label approved by the SynGO project

axonal transport
type: Class
subclass of: axo-dendritic transport
definition: The directed movement of organelles or molecules along microtubules in axons.
database_cross_reference: Wikipedia:Axoplasmic_transport
has_exact_synonym: axon cargo transport
has_exact_synonym: axoplasmic transport
has_obo_namespace: biological_process
id: GO:0098930
in_subset: goslim synapse

Axiom
annotated source: axonal transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules in axons.
database_cross_reference: ISBN:0815316194

retrograde dendritic transport
type: Class
subclass of: dendritic transport
definition: The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.
has_obo_namespace: biological_process
id: GO:0098934
in_subset: goslim synapse

Axiom
annotated source: retrograde dendritic transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.
database_cross_reference: GOC:dos

dendritic transport
type: Class
subclass of: axo-dendritic transport
definition: The directed movement of organelles or molecules along microtubules in dendrites.
has_exact_synonym: dendrite cargo transport
has_obo_namespace: biological_process
id: GO:0098935
in_subset: goslim synapse

Axiom
annotated source: dendritic transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules in dendrites.
database_cross_reference: ISBN:0815316194

anterograde dendritic transport
type: Class
subclass of: dendritic transport
definition: The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.
has_obo_namespace: biological_process
id: GO:0098937
in_subset: goslim synapse

Axiom
annotated source: anterograde dendritic transport
annotated property: definition
annotated target: The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.
database_cross_reference: ISBN:0815316194

actin cytoskeleton of dendritic spine
type: Class
subclass of: postsynaptic actin cytoskeleton
subclass of: Restriction
  on property: part of
  some values from: dendritic spine
definition: The actin cytoskeleton that is part of a dendritic spine.
has_obo_namespace: cellular_component
id: GO:0098938
in_subset: goslim synapse

Axiom
annotated source: actin cytoskeleton of dendritic spine
annotated property: definition
annotated target: The actin cytoskeleton that is part of a dendritic spine.
database_cross_reference: GOC:dos

dendritic transport of mitochondrion
type: Class
subclass of: dendritic transport
definition: The directed movement of mitochondria along microtubules in nerve cell dendrites.
has_obo_namespace: biological_process
id: GO:0098939
in_subset: goslim synapse

Axiom
annotated source: dendritic transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in nerve cell dendrites.
database_cross_reference: GOC:ai

anterograde trans-synaptic signaling by nitric oxide
type: Class
subclass of: trans-synaptic signaling by nitric oxide
definition: Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide.
has_obo_namespace: biological_process
id: GO:0098940
in_subset: goslim synapse

Axiom
annotated source: anterograde trans-synaptic signaling by nitric oxide
annotated property: definition
annotated target: Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide.
database_cross_reference: GOC:dos

anterograde trans-synaptic signaling by trans-synaptic protein complex
type: Class
subclass of: trans-synaptic signaling by trans-synaptic complex
definition: Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex.
has_obo_namespace: biological_process
id: GO:0098941
in_subset: goslim synapse

Axiom
annotated source: anterograde trans-synaptic signaling by trans-synaptic protein complex
annotated property: definition
annotated target: Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by trans-synaptic protein complex
type: Class
subclass of: trans-synaptic signaling by trans-synaptic complex
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.
has_obo_namespace: biological_process
id: GO:0098942
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by trans-synaptic protein complex
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.
database_cross_reference: GOC:dos

neurotransmitter receptor transport, postsynaptic endosome to lysosome
type: Class
subclass of: neurotransmitter receptor transport
definition: The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
has_broad_synonym: postsynaptic neurotransmitter receptor endosomal trafficking
has_obo_namespace: biological_process
id: GO:0098943
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport, postsynaptic endosome to lysosome
annotated property: definition
annotated target: The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
database_cross_reference: GOC:dos

postsynaptic recycling endosome membrane
type: Class
subclass of: postsynaptic endosome membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic recycling endosome
definition: The lipid bilayer surrounding a postsynaptic recycling endosome.
has_obo_namespace: cellular_component
id: GO:0098944
in_subset: goslim synapse

Axiom
annotated source: postsynaptic recycling endosome membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a postsynaptic recycling endosome.
database_cross_reference: GOC:pz

presynaptic endosome membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynaptic endosome
definition: The lipid bilayer surrounding a presynaptic endosome.
has_obo_namespace: cellular_component
id: GO:0098954
in_subset: goslim synapse

Axiom
annotated source: presynaptic endosome membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a presynaptic endosome.
database_cross_reference: GOC:pz

anterograde axonal transport of mitochondrion
type: Class
subclass of: anterograde axonal transport
subclass of: axonal transport of mitochondrion
definition: The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
has_exact_synonym: anterograde axon transport of mitochondria
has_obo_namespace: biological_process
id: GO:0098957
in_subset: goslim synapse

Axiom
annotated source: anterograde axonal transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
database_cross_reference: GOC:dos

retrograde axonal transport of mitochondrion
type: Class
subclass of: retrograde axonal transport
subclass of: axonal transport of mitochondrion
definition: The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse.
has_exact_synonym: retrograde axon transport of mitochondria
has_obo_namespace: biological_process
id: GO:0098958
in_subset: goslim synapse

Axiom
annotated source: retrograde axonal transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse.
database_cross_reference: GOC:dos

retrograde dendritic transport of mitochondrion
type: Class
subclass of: dendritic transport of mitochondrion
definition: The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse.
has_exact_synonym: retrograde dendrite transport of mitochondria
has_obo_namespace: biological_process
id: GO:0098959
in_subset: goslim synapse

Axiom
annotated source: retrograde dendritic transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse.
database_cross_reference: GOC:dos

dendritic transport of ribonucleoprotein complex
type: Class
subclass of: dendritic transport
definition: The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites.
has_exact_synonym: dendritic transport of RNP complex
has_obo_namespace: biological_process
id: GO:0098961
in_subset: goslim synapse

Axiom
annotated source: dendritic transport of ribonucleoprotein complex
annotated property: definition
annotated target: The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites.
database_cross_reference: GOC:dos

regulation of postsynaptic neurotransmitter receptor activity
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: regulation of neurotransmitter receptor activity
definition: Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors.
has_obo_namespace: biological_process
id: GO:0098962
in_subset: gocheck do not annotate
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic neurotransmitter receptor activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors.
database_cross_reference: GOC:dos

dendritic transport of messenger ribonucleoprotein complex
type: Class
subclass of: dendritic transport
definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.
has_exact_synonym: dendritic transport of mRNA RNP complex
has_obo_namespace: biological_process
id: GO:0098963
in_subset: goslim synapse

Axiom
annotated source: dendritic transport of messenger ribonucleoprotein complex
annotated property: definition
annotated target: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.
database_cross_reference: GOC:dos

anterograde dendritic transport of messenger ribonucleoprotein complex
type: Class
subclass of: anterograde dendritic transport
definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.
has_exact_synonym: anterograde dendritic transport of mRNA RNP complex
has_obo_namespace: biological_process
id: GO:0098964
in_subset: goslim synapse

Axiom
annotated source: anterograde dendritic transport of messenger ribonucleoprotein complex
annotated property: definition
annotated target: The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.
database_cross_reference: GOC:dos

extracellular matrix of synaptic cleft
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse-associated extracellular matrix
definition: The portion of the extracellular matrix that lies within the synaptic cleft.
has_exact_synonym: ECM of synaptic cleft
has_exact_synonym: synaptic cleft ECM
has_obo_namespace: cellular_component
id: GO:0098965
in_subset: goslim synapse

Axiom
annotated source: extracellular matrix of synaptic cleft
annotated property: definition
annotated target: The portion of the extracellular matrix that lies within the synaptic cleft.
database_cross_reference: GOC:dos

perisynaptic extracellular matrix
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse-associated extracellular matrix
definition: The portion of the extracellular matrix that lies within the perisynaptic space.
has_exact_synonym: extrasynaptic extracellular matrix
has_exact_synonym: perisynaptic ECM
has_obo_namespace: cellular_component
id: GO:0098966
in_subset: goslim synapse

Axiom
annotated source: perisynaptic extracellular matrix
annotated property: definition
annotated target: The portion of the extracellular matrix that lies within the perisynaptic space.
database_cross_reference: GOC:dos

exocytic insertion of neurotransmitter receptor to postsynaptic membrane
type: Class
subclass of: regulation of postsynaptic membrane neurotransmitter receptor levels
subclass of: Restriction
  on property: part of
  some values from: neurotransmitter receptor transport to postsynaptic membrane
definition: The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
has_obo_namespace: biological_process
id: GO:0098967
in_subset: goslim synapse

Axiom
annotated source: exocytic insertion of neurotransmitter receptor to postsynaptic membrane
annotated property: definition
annotated target: The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
database_cross_reference: PMID:19503082

neurotransmitter receptor transport postsynaptic membrane to endosome
type: Class
subclass of: neurotransmitter receptor transport
definition: Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.
has_obo_namespace: biological_process
id: GO:0098968
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport postsynaptic membrane to endosome
annotated property: definition
annotated target: Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.
database_cross_reference: GOC:dos

neurotransmitter receptor transport to postsynaptic membrane
type: Class
subclass of: neurotransmitter receptor transport to plasma membrane
subclass of: regulation of postsynaptic membrane neurotransmitter receptor levels
definition: The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.
has_obo_namespace: biological_process
id: GO:0098969
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport to postsynaptic membrane
annotated property: definition
annotated target: The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.
database_cross_reference: GOC:dos

postsynaptic neurotransmitter receptor diffusion trapping
type: Class
subclass of: regulation of postsynaptic membrane neurotransmitter receptor levels
subclass of: neurotransmitter receptor diffusion trapping
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic specialization membrane
definition: The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
has_obo_namespace: biological_process
id: GO:0098970
in_subset: goslim synapse

Axiom
annotated source: postsynaptic neurotransmitter receptor diffusion trapping
annotated property: definition
annotated target: The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
database_cross_reference: PMID:18832033

anterograde dendritic transport of neurotransmitter receptor complex
type: Class
subclass of: anterograde dendritic transport
definition: The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
has_obo_namespace: biological_process
id: GO:0098971
in_subset: goslim synapse

Axiom
annotated source: anterograde dendritic transport of neurotransmitter receptor complex
annotated property: definition
annotated target: The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
database_cross_reference: GOC:dos

anterograde dendritic transport of mitochondrion
type: Class
subclass of: anterograde dendritic transport
subclass of: dendritic transport of mitochondrion
definition: The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body.
has_obo_namespace: biological_process
id: GO:0098972
in_subset: goslim synapse

Axiom
annotated source: anterograde dendritic transport of mitochondrion
annotated property: definition
annotated target: The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body.
database_cross_reference: GOC:dos

structural constituent of postsynaptic actin cytoskeleton
type: Class
subclass of: structural constituent of postsynapse
subclass of: Restriction
  on property: part of
  some values from: postsynaptic actin cytoskeleton organization
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic actin cytoskeleton
definition: The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.
has_obo_namespace: molecular_function
id: GO:0098973
in_subset: goslim synapse

Axiom
annotated source: structural constituent of postsynaptic actin cytoskeleton
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.
database_cross_reference: GOC:dos

postsynaptic actin cytoskeleton organization
type: Class
subclass of: postsynaptic cytoskeleton organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
has_obo_namespace: biological_process
id: GO:0098974
in_subset: goslim synapse

Axiom
annotated source: postsynaptic actin cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
database_cross_reference: GOC:dos

glutamatergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses glutamate as a neurotransmitter.
has_obo_namespace: cellular_component
id: GO:0098978
in_subset: goslim synapse

Axiom
annotated source: glutamatergic synapse
annotated property: definition
annotated target: A synapse that uses glutamate as a neurotransmitter.
database_cross_reference: GOC:dos

cholinergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses acetylcholine as a neurotransmitter.
has_obo_namespace: cellular_component
id: GO:0098981
in_subset: goslim synapse

Axiom
annotated source: cholinergic synapse
annotated property: definition
annotated target: A synapse that uses acetylcholine as a neurotransmitter.
database_cross_reference: GOC:dos

GABA-ergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
has_obo_namespace: cellular_component
id: GO:0098982
in_subset: goslim synapse

Axiom
annotated source: GABA-ergic synapse
annotated property: definition
annotated target: A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
database_cross_reference: GOC:dos

regulation of modification of synapse structure, modulating synaptic transmission
type: Class
equivalent class: Class
  intersection of: regulation of modification of synaptic structure
  intersection of: Restriction
    on property: regulates
    some values from: chemical synaptic transmission
subclass of: modulation of chemical synaptic transmission
subclass of: regulation of modification of synaptic structure
definition: Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.
has_obo_namespace: biological_process
id: GO:0098987
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of modification of synapse structure, modulating synaptic transmission
annotated property: definition
annotated target: Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.
database_cross_reference: GOC:dos

AMPA selective glutamate receptor signaling pathway
type: Class
definition: The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
has_obo_namespace: biological_process
id: GO:0098990
in_subset: goslim synapse

Axiom
annotated source: AMPA selective glutamate receptor signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
database_cross_reference: GOC:dos
database_cross_reference: ISBN:9780071120005

kainate selective glutamate receptor signaling pathway
type: Class
definition: The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription.
has_obo_namespace: biological_process
id: GO:0098991
in_subset: goslim synapse

Axiom
annotated source: kainate selective glutamate receptor signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription.
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:9780071120005

neuronal dense core vesicle
type: Class
definition: A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
has_obo_namespace: cellular_component
id: GO:0098992
in_subset: goslim synapse

Axiom
annotated source: neuronal dense core vesicle
annotated property: definition
annotated target: A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
database_cross_reference: GOC:dos
database_cross_reference: ISBN:978-0-07-181001-2
database_cross_reference: Wikipedia:Neuropeptide&oldid=713905176

extrinsic component of postsynaptic early endosome membrane
type: Class
subclass of: extrinsic component of postsynaptic endosome membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic early endosome membrane
definition: The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098998
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic early endosome membrane
annotated property: definition
annotated target: The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of postsynaptic endosome membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynaptic endosome membrane
definition: The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0098999
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic endosome membrane
annotated property: definition
annotated target: The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

vesicle-mediated transport in synapse
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Any vesicle-mediated transport that occurs in a synapse.
has_obo_namespace: biological_process
id: GO:0099003
in_subset: goslim synapse

Axiom
annotated source: vesicle-mediated transport in synapse
annotated property: definition
annotated target: Any vesicle-mediated transport that occurs in a synapse.
database_cross_reference: GOC:dos

extrinsic component of postsynaptic recycling endosome membrane
type: Class
subclass of: extrinsic component of postsynaptic endosome membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic recycling endosome membrane
definition: The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0099005
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic recycling endosome membrane
annotated property: definition
annotated target: The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

extrinsic component of presynaptic endosome membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynaptic endosome membrane
definition: The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
has_obo_namespace: cellular_component
id: GO:0099007
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of presynaptic endosome membrane
annotated property: definition
annotated target: The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

modification of postsynaptic structure
type: Class
subclass of: modification of synaptic structure
definition: Any process that modifies the structure of a postsynapse.
has_broad_synonym: synapse remodelling
has_obo_namespace: biological_process
id: GO:0099010
in_subset: goslim synapse
comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones.

Axiom
annotated source: modification of postsynaptic structure
annotated property: definition
annotated target: Any process that modifies the structure of a postsynapse.
database_cross_reference: GOC:dos

neuronal dense core vesicle membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: neuronal dense core vesicle
definition: The lipid bilayer surrounding a neuronal dense core vesicle.
has_obo_namespace: cellular_component
id: GO:0099012
in_subset: goslim synapse

Axiom
annotated source: neuronal dense core vesicle membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a neuronal dense core vesicle.
database_cross_reference: GOC:dos

neuronal dense core vesicle lumen
type: Class
subclass of: Restriction
  on property: part of
  some values from: neuronal dense core vesicle
definition: The volume enclosed by a neuronal dense core vesicle membrane.
has_obo_namespace: cellular_component
id: GO:0099013
in_subset: goslim synapse

Axiom
annotated source: neuronal dense core vesicle lumen
annotated property: definition
annotated target: The volume enclosed by a neuronal dense core vesicle membrane.
database_cross_reference: GOC:dos

presynapse assembly
type: Class
subclass of: presynapse organization
subclass of: Restriction
  on property: part of
  some values from: synapse assembly
definition: The aggregation, arrangement and bonding together of a set of components to form a presynapse.
has_exact_synonym: presynapse biogenesis
has_exact_synonym: presynaptic terminal assembly
has_obo_namespace: biological_process
id: GO:0099054
in_subset: goslim synapse

Axiom
annotated source: presynapse assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form a presynapse.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:bf
database_cross_reference: GOC:dos
database_cross_reference: PMID:24449494

Axiom
annotated source: presynapse assembly
annotated property: has_exact_synonym
annotated target: presynapse biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: presynapse assembly
annotated property: has_exact_synonym
annotated target: presynaptic terminal assembly
database_cross_reference: PMID:24449494

regulation of postsynaptic membrane neurotransmitter receptor levels
type: Class
definition: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
has_obo_namespace: biological_process
id: GO:0099072
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic membrane neurotransmitter receptor levels
annotated property: definition
annotated target: Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
database_cross_reference: GOC:dos

retrograde trans-synaptic signaling by neuropeptide
type: Class
subclass of: trans-synaptic signaling by neuropeptide
definition: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
has_obo_namespace: biological_process
id: GO:0099082
in_subset: goslim synapse

Axiom
annotated source: retrograde trans-synaptic signaling by neuropeptide
annotated property: definition
annotated target: Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:bf
database_cross_reference: GOC:dos
database_cross_reference: PMID:19448629

retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
type: Class
subclass of: retrograde trans-synaptic signaling by neuropeptide
subclass of: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
definition: Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
has_obo_namespace: biological_process
id: GO:0099083
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
annotated property: definition
annotated target: Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:bf
database_cross_reference: GOC:dos
database_cross_reference: PMID:19448629

postsynaptic specialization organization
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse organization
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
created by: pr
creation date: 2011-07-27T05:17:12Z
has_exact_synonym: post synaptic specialization organization
has_exact_synonym: post-synaptic specialization organization
has_exact_synonym: postsynaptic specialization organisation
has_obo_namespace: biological_process
id: GO:0099084
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:sjp
database_cross_reference: PMID:21525273
database_cross_reference: PMID:26834556

anterograde axonal transport of messenger ribonucleoprotein complex
type: Class
subclass of: anterograde axonal transport
definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
has_exact_synonym: anterograde axonal transport of mRNA RNP complex
has_obo_namespace: biological_process
id: GO:0099087
in_subset: goslim synapse

Axiom
annotated source: anterograde axonal transport of messenger ribonucleoprotein complex
annotated property: definition
annotated target: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:26586091

axonal transport of messenger ribonucleoprotein complex
type: Class
subclass of: axonal transport
definition: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
has_exact_synonym: axonal transport of mRNA RNP complex
has_obo_namespace: biological_process
id: GO:0099088
in_subset: goslim synapse

Axiom
annotated source: axonal transport of messenger ribonucleoprotein complex
annotated property: definition
annotated target: The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
database_cross_reference: GOC:dos
database_cross_reference: PMID:26586091

establishment of endoplasmic reticulum localization to postsynapse
type: Class
definition: The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
has_exact_synonym: establishment of ER localization to postsynapse
has_obo_namespace: biological_process
id: GO:0099089
in_subset: goslim synapse

Axiom
annotated source: establishment of endoplasmic reticulum localization to postsynapse
annotated property: definition
annotated target: The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
database_cross_reference: GOC:dos
database_cross_reference: PMID:21151132

Axiom
annotated source: establishment of endoplasmic reticulum localization to postsynapse
annotated property: has_exact_synonym
annotated target: establishment of ER localization to postsynapse
database_cross_reference: GOC:dos

postsynaptic specialization, intracellular component
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynaptic specialization
definition: A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
has_obo_namespace: cellular_component
id: GO:0099091
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization, intracellular component
annotated property: definition
annotated target: A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
database_cross_reference: GOC:dos

postsynaptic density, intracellular component
type: Class
subclass of: postsynaptic specialization, intracellular component
subclass of: Restriction
  on property: part of
  some values from: postsynaptic density
definition: A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
has_obo_namespace: cellular_component
id: GO:0099092
in_subset: goslim synapse

Axiom
annotated source: postsynaptic density, intracellular component
annotated property: definition
annotated target: A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
database_cross_reference: GOC:dos

G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
definition: Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
has_obo_namespace: molecular_function
id: GO:0099102
in_subset: goslim synapse

Axiom
annotated source: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
database_cross_reference: GOC:dos
database_cross_reference: PMID:9429760

potassium channel activator activity involved in G protein-coupled receptor signaling pathway
type: Class
definition: Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
has_exact_synonym: potassium channel activator activity involved in G-protein coupled receptor signaling pathway
has_obo_namespace: molecular_function
id: GO:0099108
in_subset: goslim synapse
comment: Examples include G-protein beta-gamma complexes that bind to and activate potassium channels.

Axiom
annotated source: potassium channel activator activity involved in G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
database_cross_reference: PMID:9429760

negative regulation of presynaptic cytosolic calcium concentration
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process that decreases the concentration of calcium ions in the presynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0099113
in_subset: goslim synapse

Axiom
annotated source: negative regulation of presynaptic cytosolic calcium concentration
annotated property: definition
annotated target: Any process that decreases the concentration of calcium ions in the presynaptic cytosol.
database_cross_reference: GOC:dos

presynaptic actin cytoskeleton organization
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
created by: dos
creation date: 2017-06-09T18:34:19Z
has_obo_namespace: biological_process
id: GO:0099140
in_subset: goslim synapse

Axiom
annotated source: presynaptic actin cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
database_cross_reference: GOC:dos

presynaptic actin cytoskeleton
type: Class
subclass of: presynaptic cytoskeleton
definition: The actin cytoskeleton that is part of a presynapse.
created by: dos
creation date: 2017-06-09T18:36:19Z
has_obo_namespace: cellular_component
id: GO:0099143
in_subset: goslim synapse

Axiom
annotated source: presynaptic actin cytoskeleton
annotated property: definition
annotated target: The actin cytoskeleton that is part of a presynapse.
database_cross_reference: GOC:dos

regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
type: Class
subclass of: Restriction
  on property: regulates
  some values from: exocytic insertion of neurotransmitter receptor to postsynaptic membrane
definition: Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
created by: dos
creation date: 2017-06-09T18:49:26Z
has_obo_namespace: biological_process
id: GO:0099145
in_subset: goslim synapse

Axiom
annotated source: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
database_cross_reference: GOC:dos

extrinsic component of postsynaptic density membrane
type: Class
subclass of: extrinsic component of postsynaptic specialization membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic density membrane
definition: The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
created by: dos
creation date: 2017-07-05T10:44:43Z
has_obo_namespace: cellular_component
id: GO:0099147
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of postsynaptic density membrane
annotated property: definition
annotated target: The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:autophagy
database_cross_reference: GOC:mf

regulation of synaptic vesicle docking
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle docking
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle docking.
created by: dos
creation date: 2017-07-05T13:10:10Z
has_obo_namespace: biological_process
id: GO:0099148
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle docking
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle docking.
database_cross_reference: GOC:dos

regulation of postsynaptic neurotransmitter receptor internalization
type: Class
subclass of: Restriction
  on property: regulates
  some values from: postsynaptic neurotransmitter receptor internalization
definition: Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
created by: dos
creation date: 2017-07-05T13:13:49Z
has_exact_synonym: regulation of postsynaptic neurotransmitter receptor endocytosis
has_obo_namespace: biological_process
id: GO:0099149
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic neurotransmitter receptor internalization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
database_cross_reference: GOC:ai

Axiom
annotated source: regulation of postsynaptic neurotransmitter receptor internalization
annotated property: has_exact_synonym
annotated target: regulation of postsynaptic neurotransmitter receptor endocytosis
has_synonym_type: label approved by the SynGO project

regulation of postsynaptic specialization assembly
type: Class
subclass of: Restriction
  on property: regulates
  some values from: postsynaptic specialization assembly
definition: Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
created by: dos
creation date: 2017-07-05T13:20:48Z
has_obo_namespace: biological_process
id: GO:0099150
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic specialization assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
database_cross_reference: GOC:dos

regulation of postsynaptic density assembly
type: Class
subclass of: regulation of synapse assembly
subclass of: regulation of postsynaptic specialization assembly
subclass of: regulation of postsynapse organization
subclass of: Restriction
  on property: regulates
  some values from: postsynaptic density assembly
definition: Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
created by: dos
creation date: 2017-07-05T13:20:48Z
has_obo_namespace: biological_process
id: GO:0099151
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic density assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
database_cross_reference: GOC:dos

regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
type: Class
subclass of: Restriction
  on property: regulates
  some values from: neurotransmitter receptor transport, endosome to postsynaptic membrane
definition: Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
created by: dos
creation date: 2017-08-25T15:01:11Z
has_obo_namespace: biological_process
id: GO:0099152
in_subset: goslim synapse

Axiom
annotated source: regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
database_cross_reference: GOC:dos
database_cross_reference: PMID:20098723

serotonergic synapse
type: Class
subclass of: synapse
definition: A synapse that uses serotonin as a neurotransmitter.
created by: dos
creation date: 2017-07-05T14:22:05Z
has_obo_namespace: cellular_component
id: GO:0099154
in_subset: goslim synapse

Axiom
annotated source: serotonergic synapse
annotated property: definition
annotated target: A synapse that uses serotonin as a neurotransmitter.
database_cross_reference: GOC:dos

trans-synaptic signaling via exosome
type: Class
subclass of: trans-synaptic signaling
definition: Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
created by: dos
creation date: 2017-07-05T16:49:44Z
has_exact_synonym: exosome mediated transynaptic signalling
has_exact_synonym: trans-synaptic signalling via exosome
has_obo_namespace: biological_process
id: GO:0099157
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling via exosome
annotated property: definition
annotated target: Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19837038

regulation of recycling endosome localization within postsynapse
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle recycling via endosome
definition: Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
created by: dos
creation date: 2017-08-25T15:37:50Z
has_obo_namespace: biological_process
id: GO:0099158
in_subset: goslim synapse

Axiom
annotated source: regulation of recycling endosome localization within postsynapse
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:20098723

regulation of modification of postsynaptic structure
type: Class
subclass of: regulation of modification of synaptic structure
subclass of: Restriction
  on property: regulates
  some values from: modification of postsynaptic structure
definition: Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
created by: dos
creation date: 2017-08-25T15:47:55Z
has_exact_synonym: regulation of postsynapse remodelling
has_obo_namespace: biological_process
id: GO:0099159
in_subset: goslim synapse

Axiom
annotated source: regulation of modification of postsynaptic structure
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
database_cross_reference: GOC:dos

postsynaptic intermediate filament cytoskeleton
type: Class
subclass of: postsynaptic cytoskeleton
definition: The intermediate filament cytoskeleton that is part of a postsynapse.
created by: dos
creation date: 2017-08-28T15:26:08Z
has_obo_namespace: cellular_component
id: GO:0099160
in_subset: goslim synapse

Axiom
annotated source: postsynaptic intermediate filament cytoskeleton
annotated property: definition
annotated target: The intermediate filament cytoskeleton that is part of a postsynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:25869803

regulation of presynaptic dense core granule exocytosis
type: Class
subclass of: presynaptic modulation of chemical synaptic transmission
subclass of: regulation of synaptic vesicle exocytosis
subclass of: Restriction
  on property: regulates
  some values from: presynaptic dense core vesicle exocytosis
definition: Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
created by: dos
creation date: 2017-09-10T10:59:08Z
has_exact_synonym: regulation of presynaptic dense core vesicle exocytosis
has_obo_namespace: biological_process
id: GO:0099161
in_subset: goslim synapse

Axiom
annotated source: regulation of presynaptic dense core granule exocytosis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
database_cross_reference: GOC:dos
database_cross_reference: PMID:17881523

Axiom
annotated source: regulation of presynaptic dense core granule exocytosis
annotated property: has_exact_synonym
annotated target: regulation of presynaptic dense core vesicle exocytosis
has_synonym_type: label approved by the SynGO project

regulation of neurotransmitter loading into synaptic vesicle
type: Class
subclass of: regulation of synaptic vesicle cycle
subclass of: Restriction
  on property: regulates
  some values from: neurotransmitter loading into synaptic vesicle
definition: Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
created by: dos
creation date: 2017-09-10T11:07:57Z
has_exact_synonym: regulation of neurotransmitter uptake into synaptic vesicle
has_exact_synonym: regulation of synaptic vesicle neurotransmitter loading
has_obo_namespace: biological_process
id: GO:0099162
in_subset: goslim synapse

Axiom
annotated source: regulation of neurotransmitter loading into synaptic vesicle
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
database_cross_reference: GOC:dos
database_cross_reference: PMID:25176177

Axiom
annotated source: regulation of neurotransmitter loading into synaptic vesicle
annotated property: has_exact_synonym
annotated target: regulation of neurotransmitter uptake into synaptic vesicle
database_cross_reference: PMID:15217342

Axiom
annotated source: regulation of neurotransmitter loading into synaptic vesicle
annotated property: has_exact_synonym
annotated target: regulation of synaptic vesicle neurotransmitter loading
has_synonym_type: label approved by the SynGO project

synaptic signaling by nitric oxide
type: Class
subclass of: synaptic signaling
definition: Cell-cell signaling to or from a synapse, mediated by nitric oxide.
has_obo_namespace: biological_process
id: GO:0099163
in_subset: goslim synapse

Axiom
annotated source: synaptic signaling by nitric oxide
annotated property: definition
annotated target: Cell-cell signaling to or from a synapse, mediated by nitric oxide.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19038221

postsynaptic specialization membrane of symmetric synapse
type: Class
subclass of: postsynaptic specialization membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic specialization of symmetric synapse
definition: The membrane component of the postsynaptic specialization of a symmetric synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
created by: dos
creation date: 2017-09-10T11:50:44Z
has_obo_namespace: cellular_component
id: GO:0099164
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization membrane of symmetric synapse
annotated property: definition
annotated target: The membrane component of the postsynaptic specialization of a symmetric synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
database_cross_reference: GOC:dos

postsynaptic specialization of symmetric synapse, intracellular component
type: Class
subclass of: postsynaptic specialization, intracellular component
subclass of: Restriction
  on property: part of
  some values from: postsynaptic specialization of symmetric synapse
definition: A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.
created by: dos
creation date: 2017-09-10T11:54:15Z
has_obo_namespace: cellular_component
id: GO:0099165
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization of symmetric synapse, intracellular component
annotated property: definition
annotated target: A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.
database_cross_reference: GOC:dos

postsynaptic modulation of chemical synaptic transmission
type: Class
equivalent class: Class
  intersection of: modulation of chemical synaptic transmission
  intersection of: Restriction
    on property: occurs in
    some values from: postsynapse
subclass of: modulation of chemical synaptic transmission
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
created by: dos
creation date: 2017-09-11T17:09:17Z
has_obo_namespace: biological_process
id: GO:0099170
in_subset: goslim synapse

Axiom
annotated source: postsynaptic modulation of chemical synaptic transmission
annotated property: definition
annotated target: Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
database_cross_reference: GOC:dos

presynaptic modulation of chemical synaptic transmission
type: Class
equivalent class: Class
  intersection of: modulation of chemical synaptic transmission
  intersection of: Restriction
    on property: occurs in
    some values from: presynapse
subclass of: modulation of chemical synaptic transmission
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
created by: dos
creation date: 2017-09-11T17:09:31Z
has_obo_namespace: biological_process
id: GO:0099171
in_subset: goslim synapse

Axiom
annotated source: presynaptic modulation of chemical synaptic transmission
annotated property: definition
annotated target: Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
database_cross_reference: GOC:dos

presynapse organization
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.
has_exact_synonym: presynapse development
has_exact_synonym: presynapse organisation
has_obo_namespace: biological_process
has_related_synonym: presynapse morphogenesis
has_related_synonym: presynapse organization and biogenesis
id: GO:0099172
in_subset: goslim synapse

Axiom
annotated source: presynapse organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.
database_cross_reference: GOC:dos

Axiom
annotated source: presynapse organization
annotated property: has_related_synonym
annotated target: presynapse morphogenesis
database_cross_reference: GOC:BHF

Axiom
annotated source: presynapse organization
annotated property: has_related_synonym
annotated target: presynapse organization and biogenesis
database_cross_reference: GOC:mah

postsynapse organization
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
has_exact_synonym: postsynapse development
has_exact_synonym: postsynapse organisation
has_obo_namespace: biological_process
has_related_synonym: postsynapse morphogenesis
has_related_synonym: postsynapse organization and biogenesis
id: GO:0099173
in_subset: goslim synapse

Axiom
annotated source: postsynapse organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
database_cross_reference: GOC:dos

Axiom
annotated source: postsynapse organization
annotated property: has_related_synonym
annotated target: postsynapse morphogenesis
database_cross_reference: GOC:BHF

Axiom
annotated source: postsynapse organization
annotated property: has_related_synonym
annotated target: postsynapse organization and biogenesis
database_cross_reference: GOC:mah

regulation of presynapse organization
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: presynapse organization
definition: Any process that modulates the physical form of a presynapse.
has_exact_synonym: regulation of presynapse organisation
has_exact_synonym: regulation of presynapse structure
has_obo_namespace: biological_process
has_related_synonym: regulation of presynapse organization and biogenesis
id: GO:0099174
in_subset: goslim synapse

Axiom
annotated source: regulation of presynapse organization
annotated property: definition
annotated target: Any process that modulates the physical form of a presynapse.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of presynapse organization
annotated property: has_exact_synonym
annotated target: regulation of presynapse organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of presynapse organization
annotated property: has_related_synonym
annotated target: regulation of presynapse organization and biogenesis
database_cross_reference: GOC:mah

regulation of postsynapse organization
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: postsynapse organization
definition: Any process that modulates the physical form of a postsynapse.
has_exact_synonym: regulation of postsynapse organisation
has_exact_synonym: regulation of postsynapse structure
has_obo_namespace: biological_process
has_related_synonym: regulation of postsynapse organization and biogenesis
id: GO:0099175
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynapse organization
annotated property: definition
annotated target: Any process that modulates the physical form of a postsynapse.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of postsynapse organization
annotated property: has_exact_synonym
annotated target: regulation of postsynapse organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of postsynapse organization
annotated property: has_related_synonym
annotated target: regulation of postsynapse organization and biogenesis
database_cross_reference: GOC:mah

regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
type: Class
subclass of: Restriction
  on property: regulates
  some values from: retrograde trans-synaptic signaling by trans-synaptic protein complex
definition: Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
has_obo_namespace: biological_process
has_related_synonym: regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling
id: GO:0099176
in_subset: goslim synapse

Axiom
annotated source: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
database_cross_reference: GOC:dos
database_cross_reference: PMID:23209303

Axiom
annotated source: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
annotated property: has_related_synonym
annotated target: regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling
database_cross_reference: GOC:bf

regulation of synaptic membrane adhesion
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: synaptic membrane adhesion
definition: Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
has_exact_synonym: regulation of synapse adhesion between pre- and post-synapse
has_obo_namespace: biological_process
id: GO:0099179
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic membrane adhesion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
database_cross_reference: GOC:dos

Axiom
annotated source: regulation of synaptic membrane adhesion
annotated property: has_exact_synonym
annotated target: regulation of synapse adhesion between pre- and post-synapse
has_synonym_type: label approved by the SynGO project

zinc ion import into synaptic vesicle
type: Class
definition: The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
has_exact_synonym: Zn2+ import into synaptic vesicle
has_exact_synonym: zinc import into synaptic vesicle
has_obo_namespace: biological_process
id: GO:0099180
in_subset: goslim synapse

Axiom
annotated source: zinc ion import into synaptic vesicle
annotated property: definition
annotated target: The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
database_cross_reference: PMID:9990090

structural constituent of presynapse
type: Class
subclass of: structural constituent of synapse
subclass of: Restriction
  on property: part of
  some values from: presynapse organization
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The action of a molecule that contributes to the structural integrity of a presynapse.
created by: dos
creation date: 2017-12-20T13:42:46Z
has_obo_namespace: molecular_function
id: GO:0099181
in_subset: goslim synapse

Axiom
annotated source: structural constituent of presynapse
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a presynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:23751498

presynaptic intermediate filament cytoskeleton
type: Class
subclass of: presynaptic cytoskeleton
definition: The intermediate filament cytoskeleton that is part of a presynapse.
created by: dos
creation date: 2017-12-01T18:10:21Z
has_obo_namespace: cellular_component
id: GO:0099182
in_subset: goslim synapse

Axiom
annotated source: presynaptic intermediate filament cytoskeleton
annotated property: definition
annotated target: The intermediate filament cytoskeleton that is part of a presynapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by BDNF, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by BDNF
subclass of: trans-synaptic signaling, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
created by: dos
creation date: 2017-12-01T18:25:24Z
has_obo_namespace: biological_process
id: GO:0099183
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by BDNF, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

structural constituent of postsynaptic intermediate filament cytoskeleton
type: Class
subclass of: structural constituent of postsynapse
subclass of: Restriction
  on property: part of
  some values from: postsynaptic intermediate filament cytoskeleton organization
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic intermediate filament cytoskeleton
definition: The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
created by: dos
creation date: 2017-12-20T13:45:35Z
has_obo_namespace: molecular_function
id: GO:0099184
in_subset: goslim synapse

Axiom
annotated source: structural constituent of postsynaptic intermediate filament cytoskeleton
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
database_cross_reference: GOC:dos

postsynaptic intermediate filament cytoskeleton organization
type: Class
subclass of: postsynaptic cytoskeleton organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
created by: dos
creation date: 2017-12-20T13:47:30Z
has_obo_namespace: biological_process
id: GO:0099185
in_subset: goslim synapse

Axiom
annotated source: postsynaptic intermediate filament cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
database_cross_reference: GOC:dos

structural constituent of postsynapse
type: Class
subclass of: structural constituent of synapse
subclass of: Restriction
  on property: part of
  some values from: postsynapse organization
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: The action of a molecule that contributes to the structural integrity of a postsynapse.
created by: dos
creation date: 2017-12-20T14:54:33Z
has_obo_namespace: molecular_function
id: GO:0099186
in_subset: goslim synapse

Axiom
annotated source: structural constituent of postsynapse
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a postsynapse.
database_cross_reference: GOC:dos

postsynaptic cytoskeleton organization
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
created by: dos
creation date: 2017-12-20T15:06:57Z
has_obo_namespace: biological_process
id: GO:0099188
in_subset: goslim synapse

Axiom
annotated source: postsynaptic cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
database_cross_reference: GOC:dos

postsynaptic spectrin-associated cytoskeleton
type: Class
subclass of: postsynaptic cytoskeleton
definition: The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
created by: dos
creation date: 2017-12-20T15:29:09Z
has_obo_namespace: cellular_component
id: GO:0099189
in_subset: goslim synapse

Axiom
annotated source: postsynaptic spectrin-associated cytoskeleton
annotated property: definition
annotated target: The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:28576936

postsynaptic spectrin-associated cytoskeleton organization
type: Class
subclass of: postsynaptic cytoskeleton organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
created by: dos
creation date: 2017-12-20T15:34:26Z
has_obo_namespace: biological_process
id: GO:0099190
in_subset: goslim synapse

Axiom
annotated source: postsynaptic spectrin-associated cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:28576936

trans-synaptic signaling by BDNF
type: Class
subclass of: trans-synaptic signaling
definition: Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.
created by: dos
creation date: 2017-12-20T15:48:33Z
has_exact_synonym: trans-synaptic signaling by brain-derived neurotrophic factor
has_obo_namespace: biological_process
id: GO:0099191
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by BDNF
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.
database_cross_reference: GOC:dos

cerebellar Golgi cell to granule cell synapse
type: Class
subclass of: synapse
definition: A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
created by: dos
creation date: 2017-12-20T16:12:25Z
has_obo_namespace: cellular_component
id: GO:0099192
in_subset: goslim synapse

Axiom
annotated source: cerebellar Golgi cell to granule cell synapse
annotated property: definition
annotated target: A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
database_cross_reference: PMID:26134650

extrinsic component of synaptic membrane
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic membrane
definition: The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
created by: dos
creation date: 2017-05-25T17:24:23Z
has_obo_namespace: cellular_component
id: GO:0099243
in_subset: goslim synapse

Axiom
annotated source: extrinsic component of synaptic membrane
annotated property: definition
annotated target: The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
database_cross_reference: GOC:dos

calcium-dependent activation of synaptic vesicle fusion
type: Class
subclass of: regulation of synaptic vesicle fusion to presynaptic active zone membrane
subclass of: Restriction
  on property: part of
  some values from: synaptic vesicle exocytosis
subclass of: Restriction
  on property: positively regulates
  some values from: synaptic vesicle fusion to presynaptic active zone membrane
definition: The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
has_obo_namespace: biological_process
id: GO:0099502
in_subset: goslim synapse

Axiom
annotated source: calcium-dependent activation of synaptic vesicle fusion
annotated property: definition
annotated target: The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
database_cross_reference: PMID:23060190

synaptic vesicle cycle
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
has_obo_namespace: biological_process
id: GO:0099504
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle cycle
annotated property: definition
annotated target: A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:15217342

regulation of presynaptic membrane potential
type: Class
definition: Any process that modulates the potential difference across a presynaptic membrane.
has_exact_synonym: regulation of pre-synaptic membrane potential
has_obo_namespace: biological_process
id: GO:0099505
in_subset: goslim synapse

Axiom
annotated source: regulation of presynaptic membrane potential
annotated property: definition
annotated target: Any process that modulates the potential difference across a presynaptic membrane.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ef

synaptic vesicle transport along actin filament
type: Class
subclass of: synaptic vesicle cytoskeletal transport
definition: The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
has_obo_namespace: biological_process
id: GO:0099506
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle transport along actin filament
annotated property: definition
annotated target: The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
database_cross_reference: GOC:dos

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
has_broad_synonym: ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: ligand gated ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
has_exact_synonym: ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099507
in_subset: goslim synapse

Axiom
annotated source: ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
database_cross_reference: GOC:dos
database_cross_reference: PMID:15145529
database_cross_reference: PMID:19558451

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
term tracker item: https://github.com/geneontology/go-ontology/issues/24479
has_broad_synonym: voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: voltage gated ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
has_exact_synonym: voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential
has_exact_synonym: voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099508
in_subset: goslim synapse

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
database_cross_reference: GOC:dos

regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process that regulates the concentration of calcium in the presynaptic cytosol.
has_exact_synonym: regulation of presynaptic cytosolic calcium levels
has_obo_namespace: biological_process
id: GO:0099509
in_subset: goslim synapse

Axiom
annotated source: regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any process that regulates the concentration of calcium in the presynaptic cytosol.
database_cross_reference: GOC:dos

Axiom
annotated source: regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
type: Class
definition: Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
has_obo_namespace: molecular_function
id: GO:0099511
in_subset: goslim synapse

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
annotated property: definition
annotated target: Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
database_cross_reference: GOC:dos

synaptic vesicle cytoskeletal transport
type: Class
subclass of: synaptic vesicle transport
definition: The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
has_obo_namespace: biological_process
id: GO:0099514
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle cytoskeletal transport
annotated property: definition
annotated target: The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
database_cross_reference: GOC:dos

synaptic vesicle transport along microtubule
type: Class
subclass of: synaptic vesicle cytoskeletal transport
definition: The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
has_obo_namespace: biological_process
id: GO:0099517
in_subset: goslim synapse

Axiom
annotated source: synaptic vesicle transport along microtubule
annotated property: definition
annotated target: The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
database_cross_reference: GOC:dos

monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
term tracker item: https://github.com/geneontology/go-ontology/issues/24479
has_exact_synonym: ion antiporter activity involved in regulation of pre-synaptic membrane potential
has_exact_synonym: ion antiporter activity involved in regulation of presynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099520
in_subset: goslim synapse

Axiom
annotated source: monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
database_cross_reference: GOC:dos

ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
has_exact_synonym: ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential
has_exact_synonym: ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099521
in_subset: goslim synapse

Axiom
annotated source: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
database_cross_reference: GOC:dos
database_cross_reference: PMID:17220883

presynaptic cytosol
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: The region of the cytosol consisting of all cytosol that is part of the presynapse.
has_obo_namespace: cellular_component
id: GO:0099523
in_subset: goslim synapse

Axiom
annotated source: presynaptic cytosol
annotated property: definition
annotated target: The region of the cytosol consisting of all cytosol that is part of the presynapse.
database_cross_reference: GOC:dos

postsynaptic cytosol
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: The region of the cytosol consisting of all cytosol that is part of the postsynapse.
has_obo_namespace: cellular_component
id: GO:0099524
in_subset: goslim synapse

Axiom
annotated source: postsynaptic cytosol
annotated property: definition
annotated target: The region of the cytosol consisting of all cytosol that is part of the postsynapse.
database_cross_reference: GOC:dos

presynaptic dense core vesicle exocytosis
type: Class
subclass of: synaptic vesicle exocytosis
definition: The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
has_obo_namespace: biological_process
id: GO:0099525
in_subset: goslim synapse

Axiom
annotated source: presynaptic dense core vesicle exocytosis
annotated property: definition
annotated target: The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
database_cross_reference: PMID:17553987
database_cross_reference: PMID:24653208

presynapse to nucleus signaling pathway
type: Class
subclass of: presynaptic signal transduction
definition: The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
has_exact_synonym: presynaptic signaling to nucleus
has_obo_namespace: biological_process
id: GO:0099526
in_subset: goslim synapse
comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.

Axiom
annotated source: presynapse to nucleus signaling pathway
annotated property: definition
annotated target: The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
database_cross_reference: GOC:dos
database_cross_reference: PMID:24317321
database_cross_reference: PMID:25652077

postsynapse to nucleus signaling pathway
type: Class
subclass of: postsynaptic signal transduction
definition: The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
has_exact_synonym: postsynaptic signaling to nucleus
has_obo_namespace: biological_process
id: GO:0099527
in_subset: goslim synapse

Axiom
annotated source: postsynapse to nucleus signaling pathway
annotated property: definition
annotated target: The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
database_cross_reference: GOC:dos
database_cross_reference: PMID:24317321
database_cross_reference: PMID:25652077

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission, postsynaptic
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
definition: Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
has_obo_namespace: molecular_function
id: GO:0099529
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
database_cross_reference: GOC:dos

G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
definition: A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
has_exact_synonym: G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099530
in_subset: goslim synapse

Axiom
annotated source: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
database_cross_reference: GOC:dos

presynaptic process involved in chemical synaptic transmission
type: Class
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
has_obo_namespace: biological_process
id: GO:0099531
in_subset: gocheck do not annotate
in_subset: goslim synapse

Axiom
annotated source: presynaptic process involved in chemical synaptic transmission
annotated property: definition
annotated target: The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
database_cross_reference: GOC:dos

synaptic vesicle endosomal processing
type: Class
definition: The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
has_exact_synonym: synaptic vesicle processing via endosome
has_obo_namespace: biological_process
id: GO:0099532
in_subset: goslim synapse
comment: This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.

Axiom
annotated source: synaptic vesicle endosomal processing
annotated property: definition
annotated target: The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:dos

positive regulation of presynaptic cytosolic calcium concentration
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process that increases the concentration of calcium ions in the presynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0099533
in_subset: goslim synapse

Axiom
annotated source: positive regulation of presynaptic cytosolic calcium concentration
annotated property: definition
annotated target: Any process that increases the concentration of calcium ions in the presynaptic cytosol.
database_cross_reference: GOC:dos

calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic cytosol
definition: The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
has_exact_synonym: calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
has_exact_synonym: presynaptic calcium ion buffering
has_exact_synonym: regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering
has_obo_namespace: molecular_function
id: GO:0099534
in_subset: goslim synapse

Axiom
annotated source: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
database_cross_reference: PMID:24442513
database_cross_reference: PMID:26190970

Axiom
annotated source: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

synapse-associated extracellular matrix
type: Class
definition: The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
has_exact_synonym: extra-synaptic extracellular matrix
has_obo_namespace: cellular_component
id: GO:0099535
in_subset: goslim synapse

Axiom
annotated source: synapse-associated extracellular matrix
annotated property: definition
annotated target: The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
database_cross_reference: GOC:dos

synaptic signaling
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Cell-cell signaling to, from or within a synapse.
has_obo_namespace: biological_process
id: GO:0099536
in_subset: goslim drosophila
in_subset: goslim synapse

Axiom
annotated source: synaptic signaling
annotated property: definition
annotated target: Cell-cell signaling to, from or within a synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling
type: Class
subclass of: synaptic signaling
definition: Cell-cell signaling in either direction across the synaptic cleft.
has_obo_namespace: biological_process
id: GO:0099537
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling
annotated property: definition
annotated target: Cell-cell signaling in either direction across the synaptic cleft.
database_cross_reference: GOC:dos

synaptic signaling via neuropeptide
type: Class
subclass of: synaptic signaling
definition: Cell-cell signaling to or from a synapse, mediated by a peptide.
has_obo_namespace: biological_process
id: GO:0099538
in_subset: goslim synapse

Axiom
annotated source: synaptic signaling via neuropeptide
annotated property: definition
annotated target: Cell-cell signaling to or from a synapse, mediated by a peptide.
database_cross_reference: GOC:dos

neuropeptide secretion from presynapse
type: Class
subclass of: presynaptic dense core vesicle exocytosis
subclass of: Restriction
  on property: part of
  some values from: synaptic signaling via neuropeptide
definition: The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
has_exact_synonym: neuropeptide secretion from presynapse via dense core granule exocytosis
has_obo_namespace: biological_process
id: GO:0099539
in_subset: goslim synapse

Axiom
annotated source: neuropeptide secretion from presynapse
annotated property: definition
annotated target: The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
database_cross_reference: PMID:17553987
database_cross_reference: PMID:24653208

trans-synaptic signaling by neuropeptide
type: Class
subclass of: trans-synaptic signaling
subclass of: synaptic signaling via neuropeptide
definition: Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
has_obo_namespace: biological_process
id: GO:0099540
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by neuropeptide
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
database_cross_reference: GOC:dos

trans-synaptic signaling by lipid
type: Class
subclass of: trans-synaptic signaling
definition: Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
has_obo_namespace: biological_process
id: GO:0099541
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by lipid
annotated property: definition
annotated target: Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
database_cross_reference: GOC:dos

trans-synaptic signaling by endocannabinoid
type: Class
subclass of: trans-synaptic signaling by lipid
definition: Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
has_obo_namespace: biological_process
id: GO:0099542
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by endocannabinoid
annotated property: definition
annotated target: Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
database_cross_reference: GOC:dos

trans-synaptic signaling by soluble gas
type: Class
subclass of: trans-synaptic signaling
definition: Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
has_obo_namespace: biological_process
id: GO:0099543
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by soluble gas
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
database_cross_reference: GOC:dos

perisynaptic space
type: Class
definition: The extracellular region immediately adjacent to to a synapse.
has_exact_synonym: extrasynaptic space
has_obo_namespace: cellular_component
id: GO:0099544
in_subset: goslim synapse

Axiom
annotated source: perisynaptic space
annotated property: definition
annotated target: The extracellular region immediately adjacent to to a synapse.
database_cross_reference: GOC:dos

Axiom
annotated source: perisynaptic space
annotated property: has_exact_synonym
annotated target: extrasynaptic space
has_synonym_type: label approved by the SynGO project

trans-synaptic signaling by trans-synaptic complex
type: Class
subclass of: trans-synaptic signaling
definition: Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
has_obo_namespace: biological_process
id: GO:0099545
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by trans-synaptic complex
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
database_cross_reference: GOC:dos

protein catabolic process, modulating synaptic transmission
type: Class
subclass of: protein catabolic process at synapse
subclass of: Restriction
  on property: regulates
  some values from: chemical synaptic transmission
definition: Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
has_obo_namespace: biological_process
id: GO:0099546
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: protein catabolic process, modulating synaptic transmission
annotated property: definition
annotated target: Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
database_cross_reference: GOC:dos
database_cross_reference: PMID:23083742

regulation of translation at synapse, modulating synaptic transmission
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: regulation of translation at synapse
definition: Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
has_obo_namespace: biological_process
id: GO:0099547
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at synapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by nitric oxide
type: Class
subclass of: synaptic signaling by nitric oxide
subclass of: trans-synaptic signaling by soluble gas
definition: Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide.
has_obo_namespace: biological_process
id: GO:0099548
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by nitric oxide
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide.
database_cross_reference: GOC:dos

trans-synaptic signaling by carbon monoxide
type: Class
subclass of: trans-synaptic signaling by soluble gas
definition: Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide.
has_obo_namespace: biological_process
id: GO:0099549
in_subset: goslim synapse

Axiom
annotated source: trans-synaptic signaling by carbon monoxide
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide.
database_cross_reference: GOC:dos

trans-synaptic signaling, modulating synaptic transmission
type: Class
equivalent class: Class
  intersection of: trans-synaptic signaling
  intersection of: Restriction
    on property: regulates
    some values from: chemical synaptic transmission
subclass of: modulation of chemical synaptic transmission
subclass of: trans-synaptic signaling
definition: Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099550
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by neuropeptide, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by neuropeptide
subclass of: trans-synaptic signaling, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099551
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by lipid, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by lipid
subclass of: trans-synaptic signaling, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099552
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by lipid, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:21531987

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by endocannabinoid
subclass of: trans-synaptic signaling by lipid, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099553
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:21531987

trans-synaptic signaling by soluble gas, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by soluble gas
subclass of: trans-synaptic signaling, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099554
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by soluble gas, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by nitric oxide, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by nitric oxide
subclass of: trans-synaptic signaling by soluble gas, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099555
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by nitric oxide, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by carbon monoxide
subclass of: trans-synaptic signaling by soluble gas, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099556
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos

trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
type: Class
subclass of: trans-synaptic signaling by trans-synaptic complex
subclass of: trans-synaptic signaling, modulating synaptic transmission
definition: Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
has_obo_namespace: biological_process
id: GO:0099557
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
annotated property: definition
annotated target: Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19029886

maintenance of synapse structure
type: Class
subclass of: synapse organization
definition: A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
has_exact_synonym: synaptic maintenance
has_obo_namespace: biological_process
id: GO:0099558
in_subset: goslim synapse

Axiom
annotated source: maintenance of synapse structure
annotated property: definition
annotated target: A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
database_cross_reference: GOC:dos
database_cross_reference: PMID:24449494
database_cross_reference: PMID:25611509

maintenance of alignment of postsynaptic density and presynaptic active zone
type: Class
subclass of: maintenance of synapse structure
definition: The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
has_obo_namespace: biological_process
id: GO:0099559
in_subset: goslim synapse

Axiom
annotated source: maintenance of alignment of postsynaptic density and presynaptic active zone
annotated property: definition
annotated target: The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
database_cross_reference: GOC:dos

synaptic membrane adhesion
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse organization
definition: The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
has_exact_synonym: synapse adhesion between pre- and post-synapse
has_obo_namespace: biological_process
id: GO:0099560
in_subset: goslim synapse

Axiom
annotated source: synaptic membrane adhesion
annotated property: definition
annotated target: The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
database_cross_reference: GOC:dos

Axiom
annotated source: synaptic membrane adhesion
annotated property: has_exact_synonym
annotated target: synapse adhesion between pre- and post-synapse
has_synonym_type: label approved by the SynGO project

synaptic membrane adhesion to extracellular matrix
type: Class
subclass of: Restriction
  on property: part of
  some values from: synapse organization
definition: The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
has_obo_namespace: biological_process
id: GO:0099561
in_subset: goslim synapse

Axiom
annotated source: synaptic membrane adhesion to extracellular matrix
annotated property: definition
annotated target: The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
database_cross_reference: GOC:dos

maintenance of postsynaptic density structure
type: Class
subclass of: maintenance of postsynaptic specialization structure
definition: A process which maintains the organization and the arrangement of proteins in the presynaptic density.
has_obo_namespace: biological_process
id: GO:0099562
in_subset: goslim synapse

Axiom
annotated source: maintenance of postsynaptic density structure
annotated property: definition
annotated target: A process which maintains the organization and the arrangement of proteins in the presynaptic density.
database_cross_reference: GOC:dos

modification of synaptic structure
type: Class
subclass of: synapse organization
definition: Any process that modifies the structure/morphology of a synapse.
has_exact_synonym: synapse remodelling
has_obo_namespace: biological_process
id: GO:0099563
in_subset: goslim synapse
comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.

Axiom
annotated source: modification of synaptic structure
annotated property: definition
annotated target: Any process that modifies the structure/morphology of a synapse.
database_cross_reference: GOC:dos

modification of synaptic structure, modulating synaptic transmission
type: Class
subclass of: modification of synaptic structure
subclass of: Restriction
  on property: regulates
  some values from: chemical synaptic transmission
definition: Any process that modulates synaptic transmission via modification of the structure of the synapse.
has_obo_namespace: biological_process
id: GO:0099564
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: modification of synaptic structure, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission via modification of the structure of the synapse.
database_cross_reference: GOC:dos

chemical synaptic transmission, postsynaptic
type: Class
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
has_exact_synonym: postsynaptic process involved in chemical synaptic transmission
has_obo_namespace: biological_process
id: GO:0099565
in_subset: goslim synapse

Axiom
annotated source: chemical synaptic transmission, postsynaptic
annotated property: definition
annotated target: The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
database_cross_reference: GOC:dos

Axiom
annotated source: chemical synaptic transmission, postsynaptic
annotated property: has_exact_synonym
annotated target: postsynaptic process involved in chemical synaptic transmission
has_synonym_type: label approved by the SynGO project

regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Any process that regulates the concentration of calcium in the postsynaptic cytosol.
has_exact_synonym: regulation of postsynaptic cytosolic calcium levels
has_obo_namespace: biological_process
id: GO:0099566
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any process that regulates the concentration of calcium in the postsynaptic cytosol.
database_cross_reference: GOC:dos

Axiom
annotated source: regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic cytosol
definition: The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
has_exact_synonym: calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
has_exact_synonym: postsynaptic calcium ion buffering
has_obo_namespace: molecular_function
has_related_synonym: regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering
id: GO:0099567
in_subset: goslim synapse

Axiom
annotated source: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
database_cross_reference: PMID:24442513
database_cross_reference: PMID:26190970

Axiom
annotated source: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

presynaptic cytoskeleton
type: Class
subclass of: Restriction
  on property: part of
  some values from: presynapse
definition: The portion of the cytoskeleton contained within the presynapse.
has_obo_namespace: cellular_component
id: GO:0099569
in_subset: goslim synapse

Axiom
annotated source: presynaptic cytoskeleton
annotated property: definition
annotated target: The portion of the cytoskeleton contained within the presynapse.
database_cross_reference: GOC:dos

postsynaptic cytoskeleton
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: The portion of the cytoskeleton contained within the postsynapse.
has_obo_namespace: cellular_component
id: GO:0099571
in_subset: goslim synapse

Axiom
annotated source: postsynaptic cytoskeleton
annotated property: definition
annotated target: The portion of the cytoskeleton contained within the postsynapse.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19889835

postsynaptic specialization
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
has_obo_namespace: cellular_component
id: GO:0099572
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization
annotated property: definition
annotated target: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
database_cross_reference: PMID:22046028

glutamatergic postsynaptic density
type: Class
subclass of: postsynaptic density
definition: The post-synaptic specialization of a glutamatergic excitatory synapse.
has_exact_synonym: postsynaptic specialization, glutamatergic neuron-to-neuron synapse
has_obo_namespace: cellular_component
id: GO:0099573
in_subset: goslim synapse

Axiom
annotated source: glutamatergic postsynaptic density
annotated property: definition
annotated target: The post-synaptic specialization of a glutamatergic excitatory synapse.
database_cross_reference: GOC:dos

Axiom
annotated source: glutamatergic postsynaptic density
annotated property: has_exact_synonym
annotated target: postsynaptic specialization, glutamatergic neuron-to-neuron synapse
has_synonym_type: label approved by the SynGO project

regulation of protein catabolic process at synapse, modulating synaptic transmission
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: regulation protein catabolic process at synapse
definition: Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
has_obo_namespace: biological_process
id: GO:0099574
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of protein catabolic process at synapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
database_cross_reference: GOC:dos

regulation of protein catabolic process at presynapse, modulating synaptic transmission
type: Class
subclass of: presynaptic modulation of chemical synaptic transmission
definition: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
has_obo_namespace: biological_process
id: GO:0099575
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of protein catabolic process at presynapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
database_cross_reference: GOC:dos

regulation of protein catabolic process at postsynapse, modulating synaptic transmission
type: Class
subclass of: postsynaptic modulation of chemical synaptic transmission
definition: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
has_obo_namespace: biological_process
id: GO:0099576
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
database_cross_reference: GOC:dos

regulation of translation at presynapse, modulating synaptic transmission
type: Class
subclass of: presynaptic modulation of chemical synaptic transmission
subclass of: regulation of translation at synapse, modulating synaptic transmission
subclass of: regulation of translation at presynapse
definition: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
has_obo_namespace: biological_process
id: GO:0099577
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at presynapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
database_cross_reference: GOC:dos

regulation of translation at postsynapse, modulating synaptic transmission
type: Class
subclass of: postsynaptic modulation of chemical synaptic transmission
subclass of: regulation of translation at synapse, modulating synaptic transmission
subclass of: regulation of translation at postsynapse
definition: Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
has_obo_namespace: biological_process
id: GO:0099578
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at postsynapse, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
database_cross_reference: GOC:dos

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
subclass of: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
definition: A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
has_exact_synonym: G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099579
in_subset: goslim synapse

Axiom
annotated source: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
database_cross_reference: GOC:dos

monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
definition: Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
term tracker item: https://github.com/geneontology/go-ontology/issues/24479
has_exact_synonym: ion antiporter activity involved in regulation of post-synaptic membrane potential
has_exact_synonym: ion antiporter activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099580
in_subset: goslim synapse

Axiom
annotated source: monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
database_cross_reference: GOC:dos

ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
definition: Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
has_exact_synonym: ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential
has_exact_synonym: ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0099581
in_subset: goslim synapse

Axiom
annotated source: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
database_cross_reference: GOC:dos

neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
has_exact_synonym: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:0099582
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
database_cross_reference: GOC:dos

Axiom
annotated source: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission, postsynaptic
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: postsynaptic membrane
definition: Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.
has_exact_synonym: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:0099583
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.
database_cross_reference: GOC:dos

Axiom
annotated source: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

release of sequestered calcium ion into presynaptic cytosol
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0099585
in_subset: goslim synapse

Axiom
annotated source: release of sequestered calcium ion into presynaptic cytosol
annotated property: definition
annotated target: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
database_cross_reference: GOC:dos

release of sequestered calcium ion into postsynaptic cytosol
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0099586
in_subset: goslim synapse

Axiom
annotated source: release of sequestered calcium ion into postsynaptic cytosol
annotated property: definition
annotated target: The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
database_cross_reference: GOC:dos

positive regulation of postsynaptic cytosolic calcium concentration
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Any process that increases the concentration of calcium ions in the postsynaptic cytosol.
has_obo_namespace: biological_process
id: GO:0099588
in_subset: goslim synapse

Axiom
annotated source: positive regulation of postsynaptic cytosolic calcium concentration
annotated property: definition
annotated target: Any process that increases the concentration of calcium ions in the postsynaptic cytosol.
database_cross_reference: GOC:dos

regulation of neurotransmitter receptor activity
type: Class
definition: Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors.
has_obo_namespace: biological_process
id: GO:0099601
in_subset: gocheck do not annotate
in_subset: goslim synapse

Axiom
annotated source: regulation of neurotransmitter receptor activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors.
database_cross_reference: GOC:dos

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
type: Class
subclass of: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels.
has_exact_synonym: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:0099626
in_subset: goslim synapse

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
annotated property: definition
annotated target: Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels.
database_cross_reference: GOC:dos
database_cross_reference: PMID:15548655

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

neurotransmitter receptor diffusion trapping
type: Class
definition: The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane.
has_obo_namespace: biological_process
id: GO:0099628
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor diffusion trapping
annotated property: definition
annotated target: The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane.
database_cross_reference: PMID:18832033

postsynaptic specialization of symmetric synapse
type: Class
subclass of: postsynaptic specialization
definition: A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses.
has_exact_synonym: postsynaptic density of inhibitory synapse
has_obo_namespace: cellular_component
id: GO:0099629
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization of symmetric synapse
annotated property: definition
annotated target: A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses.
database_cross_reference: PMID:18832033

Axiom
annotated source: postsynaptic specialization of symmetric synapse
annotated property: has_exact_synonym
annotated target: postsynaptic density of inhibitory synapse
database_cross_reference: PMID:18832033

postsynaptic endocytic zone cytoplasmic component
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynaptic endocytic zone
definition: The cytoplasmic component of the postsynaptic endocytic zone.
has_obo_namespace: cellular_component
id: GO:0099631
in_subset: goslim synapse

Axiom
annotated source: postsynaptic endocytic zone cytoplasmic component
annotated property: definition
annotated target: The cytoplasmic component of the postsynaptic endocytic zone.
database_cross_reference: GOC:dos

postsynaptic specialization membrane
type: Class
subclass of: synaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic membrane
subclass of: Restriction
  on property: part of
  some values from: postsynaptic specialization
definition: The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
has_obo_namespace: cellular_component
id: GO:0099634
in_subset: goslim synapse

Axiom
annotated source: postsynaptic specialization membrane
annotated property: definition
annotated target: The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
database_cross_reference: GOC:dos

voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
type: Class
subclass of: Restriction
  on property: part of
  some values from: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.
database_cross_reference: Reactome:R-HSA-9659515
has_obo_namespace: molecular_function
id: GO:0099635
in_subset: goslim synapse

Axiom
annotated source: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
annotated property: definition
annotated target: Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.
database_cross_reference: GOC:dos

CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell
type: Axiom
annotated source: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9659515

neurotransmitter receptor transport
type: Class
definition: The directed movement of neurotransmitter receptors.
has_obo_namespace: biological_process
id: GO:0099637
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport
annotated property: definition
annotated target: The directed movement of neurotransmitter receptors.
database_cross_reference: GOC:dos

neurotransmitter receptor transport, endosome to plasma membrane
type: Class
subclass of: neurotransmitter receptor transport to plasma membrane
definition: The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
has_obo_namespace: biological_process
id: GO:0099639
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport, endosome to plasma membrane
annotated property: definition
annotated target: The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
database_cross_reference: GOC:dos

axo-dendritic protein transport
type: Class
subclass of: axo-dendritic transport
definition: The directed movement of proteins along microtubules in neuron projections.
has_narrow_synonym: axonal protein transport
has_obo_namespace: biological_process
id: GO:0099640
in_subset: goslim synapse

Axiom
annotated source: axo-dendritic protein transport
annotated property: definition
annotated target: The directed movement of proteins along microtubules in neuron projections.
database_cross_reference: ISBN:0815316194

anterograde axonal protein transport
type: Class
subclass of: anterograde axonal transport
subclass of: axo-dendritic protein transport
definition: The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
has_broad_synonym: anterograde axon cargo transport
has_obo_namespace: biological_process
id: GO:0099641
in_subset: goslim synapse

Axiom
annotated source: anterograde axonal protein transport
annotated property: definition
annotated target: The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
database_cross_reference: GOC:dos

retrograde axonal protein transport
type: Class
subclass of: retrograde axonal transport
subclass of: axo-dendritic protein transport
definition: The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
has_broad_synonym: retrograde axon cargo transport
has_obo_namespace: biological_process
id: GO:0099642
in_subset: goslim synapse

Axiom
annotated source: retrograde axonal protein transport
annotated property: definition
annotated target: The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
database_cross_reference: ISBN:0815316194

signal release from synapse
type: Class
subclass of: Restriction
  on property: part of
  some values from: synaptic signaling
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Any signal release from a synapse.
has_obo_namespace: biological_process
id: GO:0099643
in_subset: goslim synapse

Axiom
annotated source: signal release from synapse
annotated property: definition
annotated target: Any signal release from a synapse.
database_cross_reference: GOC:dos

neurotransmitter receptor localization to postsynaptic specialization membrane
type: Class
subclass of: regulation of postsynaptic membrane neurotransmitter receptor levels
definition: A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
has_exact_synonym: neurotransmitter receptor localisation in postsynaptic specialization membrane
has_obo_namespace: biological_process
id: GO:0099645
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor localization to postsynaptic specialization membrane
annotated property: definition
annotated target: A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
database_cross_reference: GOC:dos

Axiom
annotated source: neurotransmitter receptor localization to postsynaptic specialization membrane
annotated property: has_exact_synonym
annotated target: neurotransmitter receptor localisation in postsynaptic specialization membrane
database_cross_reference: GOC:TermGenie

neurotransmitter receptor transport, plasma membrane to endosome
type: Class
subclass of: neurotransmitter receptor transport
definition: Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome.
has_obo_namespace: biological_process
id: GO:0099646
in_subset: goslim synapse

Axiom
annotated source: neurotransmitter receptor transport, plasma membrane to endosome
annotated property: definition
annotated target: Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome.
database_cross_reference: GOC:dos

induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
type: Class
equivalent class: Class
  intersection of: positive regulation of presynaptic cytosolic calcium concentration
  intersection of: Restriction
    on property: positively regulates
    some values from: synaptic vesicle exocytosis
subclass of: presynaptic modulation of chemical synaptic transmission
subclass of: positive regulation of presynaptic cytosolic calcium concentration
subclass of: regulation of synaptic vesicle exocytosis
subclass of: Restriction
  on property: part of
  some values from: chemical synaptic transmission
subclass of: Restriction
  on property: positively regulates
  some values from: chemical synaptic transmission
subclass of: Restriction
  on property: positively regulates
  some values from: neurotransmitter secretion
subclass of: Restriction
  on property: positively regulates
  some values from: synaptic vesicle exocytosis
definition: The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission.
has_obo_namespace: biological_process
id: GO:0099703
in_subset: goslim synapse

Axiom
annotated source: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission.
database_cross_reference: GOC:dos
database_cross_reference: ISBN:9780071120005

anterograde axonal transport of neurotransmitter receptor complex
type: Class
subclass of: neurotransmitter receptor transport
subclass of: anterograde axonal protein transport
definition: The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
created by: pg
creation date: 2018-07-09T09:41:37Z
has_obo_namespace: biological_process
id: GO:0140231
in_subset: goslim synapse

Axiom
annotated source: anterograde axonal transport of neurotransmitter receptor complex
annotated property: definition
annotated target: The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
database_cross_reference: PMID:28680963

intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
definition: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
term tracker item: https://github.com/geneontology/synapse/issues/231
created by: pg
creation date: 2018-07-09T11:30:40Z
has_exact_synonym: intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0140232
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
database_cross_reference: PMID:21358644

intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
definition: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
term tracker item: https://github.com/geneontology/synapse/issues/231
created by: pg
creation date: 2018-07-09T11:31:18Z
has_exact_synonym: intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0140233
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
database_cross_reference: GOC:pvn

RNA polyadenylation at postsynapse
type: Class
definition: A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
created by: pg
creation date: 2018-07-13T12:03:28Z
has_obo_namespace: biological_process
id: GO:0140235
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: RNA polyadenylation at postsynapse
annotated property: definition
annotated target: A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
database_cross_reference: PMID:22727665

translation at presynapse
type: Class
subclass of: translation at synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Translation that occurs at the presynapse.
term tracker item: https://github.com/geneontology/synapse/issues/216
created by: pg
creation date: 2018-07-13T13:00:33Z
has_obo_namespace: biological_process
id: GO:0140236
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: translation at presynapse
annotated property: definition
annotated target: Translation that occurs at the presynapse.
database_cross_reference: PMID:27321671

translation at presynapse, modulating chemical synaptic transmission
type: Class
subclass of: translation at presynapse
subclass of: Restriction
  on property: regulates
  some values from: chemical synaptic transmission
definition: Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
term tracker item: https://github.com/geneontology/synapse/issues/216
created by: pg
creation date: 2018-07-13T13:07:23Z
has_obo_namespace: biological_process
id: GO:0140237
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: translation at presynapse, modulating chemical synaptic transmission
annotated property: definition
annotated target: Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
database_cross_reference: PMID:27321671

presynaptic endocytosis
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
term tracker item: https://github.com/geneontology/synapse/issues/230
created by: pg
creation date: 2018-07-15T07:33:55Z
has_obo_namespace: biological_process
id: GO:0140238
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: presynaptic endocytosis
annotated property: definition
annotated target: A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
database_cross_reference: PMID:24719103

postsynaptic endocytosis
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
term tracker item: https://github.com/geneontology/synapse/issues/230
created by: pg
creation date: 2018-07-15T07:38:27Z
has_obo_namespace: biological_process
id: GO:0140239
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: postsynaptic endocytosis
annotated property: definition
annotated target: A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
database_cross_reference: PMID:12839988

perforant pathway to dendrate granule cell synapse
type: Class
subclass of: synapse
definition: A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
term tracker item: https://github.com/geneontology/synapse/issues/234
created by: pg
creation date: 2018-07-15T08:21:43Z
has_exact_synonym: perforant pathway to DG granule cell synapse
has_obo_namespace: cellular_component
id: GO:0140240
in_subset: goslim synapse

Axiom
annotated source: perforant pathway to dendrate granule cell synapse
annotated property: definition
annotated target: A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
database_cross_reference: PMID:22727665
database_cross_reference: PMID:29199135

translation at synapse
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Translation that occurs at the synapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T09:23:12Z
has_obo_namespace: biological_process
id: GO:0140241
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: translation at synapse
annotated property: definition
annotated target: Translation that occurs at the synapse.
database_cross_reference: PMID:23083742

translation at postsynapse
type: Class
subclass of: translation at synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Translation that occurs at the postsynapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T09:26:27Z
has_obo_namespace: biological_process
id: GO:0140242
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: translation at postsynapse
annotated property: definition
annotated target: Translation that occurs at the postsynapse.
database_cross_reference: PMID:20427644

regulation of translation at synapse
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Any process that regulates translation occurring at the synapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T09:38:26Z
has_obo_namespace: biological_process
id: GO:0140243
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at synapse
annotated property: definition
annotated target: Any process that regulates translation occurring at the synapse.
database_cross_reference: PMID:20427644

regulation of translation at presynapse
type: Class
subclass of: regulation of translation at synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process that regulates translation occurring at the presynapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T09:38:33Z
has_obo_namespace: biological_process
id: GO:0140244
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at presynapse
annotated property: definition
annotated target: Any process that regulates translation occurring at the presynapse.
database_cross_reference: PMID:20427644

regulation of translation at postsynapse
type: Class
subclass of: regulation of translation at synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Any process that regulates translation occurring at the postsynapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T09:38:54Z
has_obo_namespace: biological_process
id: GO:0140245
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of translation at postsynapse
annotated property: definition
annotated target: Any process that regulates translation occurring at the postsynapse.
database_cross_reference: PMID:20427644

protein catabolic process at synapse
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
term tracker item: https://github.com/geneontology/synapse/issues/210
created by: pg
creation date: 2018-07-15T10:12:51Z
has_obo_namespace: biological_process
id: GO:0140246
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: protein catabolic process at synapse
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
database_cross_reference: PMID:17062563

protein catabolic process at presynapse
type: Class
subclass of: protein catabolic process at synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
term tracker item: https://github.com/geneontology/synapse/issues/204
created by: pg
creation date: 2018-07-15T10:23:49Z
has_obo_namespace: biological_process
id: GO:0140247
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: protein catabolic process at presynapse
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
database_cross_reference: PMID:27764673

protein catabolic process at postsynapse
type: Class
subclass of: protein catabolic process at synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
term tracker item: https://github.com/geneontology/synapse/issues/204
created by: pg
creation date: 2018-07-15T10:25:04Z
has_obo_namespace: biological_process
id: GO:0140249
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: protein catabolic process at postsynapse
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
database_cross_reference: PMID:17062563

regulation protein catabolic process at synapse
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
term tracker item: https://github.com/geneontology/synapse/issues/204
created by: pg
creation date: 2018-07-15T10:34:56Z
has_obo_namespace: biological_process
id: GO:0140250
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation protein catabolic process at synapse
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
database_cross_reference: PMID:23083742

regulation protein catabolic process at presynapse
type: Class
subclass of: regulation protein catabolic process at synapse
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
term tracker item: https://github.com/geneontology/synapse/issues/204
created by: pg
creation date: 2018-07-15T10:35:39Z
has_obo_namespace: biological_process
id: GO:0140251
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation protein catabolic process at presynapse
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
database_cross_reference: PMID:27764673

regulation protein catabolic process at postsynapse
type: Class
subclass of: regulation protein catabolic process at synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
term tracker item: https://github.com/geneontology/synapse/issues/204
created by: pg
creation date: 2018-07-15T10:35:56Z
has_obo_namespace: biological_process
id: GO:0140252
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation protein catabolic process at postsynapse
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
database_cross_reference: PMID:17062563

regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: Restriction
  on property: regulates
  some values from: trans-synaptic signaling by BDNF, modulating synaptic transmission
definition: Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.
created by: bc
creation date: 2018-04-17T13:56:34Z
has_obo_namespace: biological_process
id: GO:0150035
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:19448629

regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: Restriction
  on property: regulates
  some values from: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
definition: Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.
created by: bc
creation date: 2018-04-18T09:54:49Z
has_obo_namespace: biological_process
id: GO:0150036
in_subset: goslim synapse
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.

Axiom
annotated source: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:27296803

regulation of calcium-dependent activation of synaptic vesicle fusion
type: Class
subclass of: regulation of synaptic vesicle fusion to presynaptic active zone membrane
subclass of: Restriction
  on property: regulates
  some values from: calcium-dependent activation of synaptic vesicle fusion
definition: Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.
created by: bc
creation date: 2018-04-18T12:47:38Z
has_obo_namespace: biological_process
id: GO:0150037
in_subset: goslim synapse

Axiom
annotated source: regulation of calcium-dependent activation of synaptic vesicle fusion
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:27052163

postsynaptic dense core vesicle exocytosis
type: Class
subclass of: vesicle-mediated transport in synapse
subclass of: Restriction
  on property: occurs in
  some values from: postsynapse
definition: The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.
created by: bc
creation date: 2018-04-18T14:32:16Z
has_obo_namespace: biological_process
id: GO:0150038
in_subset: goslim synapse

Axiom
annotated source: postsynaptic dense core vesicle exocytosis
annotated property: definition
annotated target: The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:19448629

structural constituent of synapse-associated extracellular matrix
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse-associated extracellular matrix
definition: The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
created by: bc
creation date: 2018-04-19T13:42:40Z
has_exact_synonym: extra-synaptic extracellular matrix structural constituent
has_exact_synonym: structural constituent of extra-synaptic extracellular matrix
has_exact_synonym: synapse-associated extracellular matrix structural constituent
has_obo_namespace: molecular_function
id: GO:0150043
in_subset: goslim synapse

Axiom
annotated source: structural constituent of synapse-associated extracellular matrix
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:17189701

regulation of postsynaptic dense core vesicle exocytosis
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: presynapse
subclass of: Restriction
  on property: regulates
  some values from: postsynaptic dense core vesicle exocytosis
definition: Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.
created by: bc
creation date: 2018-04-20T13:34:32Z
has_obo_namespace: biological_process
id: GO:0150044
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic dense core vesicle exocytosis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:19448629

regulation of synaptic signaling by nitric oxide
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic signaling by nitric oxide
definition: Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.
created by: bc
creation date: 2018-04-23T09:42:25Z
has_obo_namespace: biological_process
id: GO:0150045
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic signaling by nitric oxide
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:26311509

G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic membrane potential
subclass of: Restriction
  on property: occurs in
  some values from: presynaptic membrane
definition: G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.
created by: bc
creation date: 2018-04-23T10:51:20Z
has_exact_synonym: G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:0150047
in_subset: goslim synapse

Axiom
annotated source: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
annotated property: definition
annotated target: G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:11498050

cerebellar granule cell to Purkinje cell synapse
type: Class
subclass of: glutamatergic synapse
subclass of: Restriction
  on property: has part
  some values from: postsynaptic density
definition: A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.
created by: bc
creation date: 2018-04-23T14:44:40Z
has_exact_synonym: cerebellar parallel fiber to Purkinje cell synapse
has_obo_namespace: cellular_component
id: GO:0150048
in_subset: goslim synapse

Axiom
annotated source: cerebellar granule cell to Purkinje cell synapse
annotated property: definition
annotated target: A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:12427822

postsynaptic septin cytoskeleton
type: Class
subclass of: postsynaptic cytoskeleton
definition: The portion of the septin cytoskeleton contained within the postsynapse.
created by: bc
creation date: 2018-04-26T14:45:52Z
has_obo_namespace: cellular_component
id: GO:0150050
in_subset: goslim synapse

Axiom
annotated source: postsynaptic septin cytoskeleton
annotated property: definition
annotated target: The portion of the septin cytoskeleton contained within the postsynapse.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:28065648

postsynaptic Golgi apparatus
type: Class
subclass of: Restriction
  on property: part of
  some values from: postsynapse
definition: The network of the Golgi apparatus structures located within the postsynapse.
created by: bc
creation date: 2018-05-08T15:42:56Z
has_obo_namespace: cellular_component
has_related_synonym: Golgi outpost
id: GO:0150051
in_subset: goslim synapse

Axiom
annotated source: postsynaptic Golgi apparatus
annotated property: definition
annotated target: The network of the Golgi apparatus structures located within the postsynapse.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:23838184

Axiom
annotated source: postsynaptic Golgi apparatus
annotated property: has_related_synonym
annotated target: Golgi outpost
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:21215635

regulation of postsynapse assembly
type: Class
subclass of: regulation of synapse assembly
subclass of: regulation of postsynapse organization
definition: Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
created by: bc
creation date: 2018-05-08T16:38:55Z
has_obo_namespace: biological_process
id: GO:0150052
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynapse assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:16394100
database_cross_reference: PMID:16672654
database_cross_reference: PMID:28185854

cerebellar climbing fiber to Purkinje cell synapse
type: Class
subclass of: glutamatergic synapse
subclass of: Restriction
  on property: has part
  some values from: postsynaptic density
definition: A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.
created by: bc
creation date: 2018-05-09T09:57:20Z
has_exact_synonym: cerebellar climbing fibre to Purkinje cell synapse
has_obo_namespace: cellular_component
id: GO:0150053
in_subset: goslim synapse

Axiom
annotated source: cerebellar climbing fiber to Purkinje cell synapse
annotated property: definition
annotated target: A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:19597563
database_cross_reference: PMID:23811844
database_cross_reference: PMID:5044254

regulation of postsynaptic neurotransmitter receptor diffusion trapping
type: Class
subclass of: Restriction
  on property: regulates
  some values from: postsynaptic neurotransmitter receptor diffusion trapping
definition: Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.
created by: bc
creation date: 2018-05-10T14:26:59Z
has_obo_namespace: biological_process
id: GO:0150054
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynaptic neurotransmitter receptor diffusion trapping
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: PMID:20935643

regulation of synaptic vesicle endocytosis
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle endocytosis
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
created by: rl
creation date: 2012-03-28T01:40:26Z
has_obo_namespace: biological_process
has_related_synonym: regulation of synaptic vesicle retrieval
id: GO:1900242
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle endocytosis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:TermGenie

Axiom
annotated source: regulation of synaptic vesicle endocytosis
annotated property: has_related_synonym
annotated target: regulation of synaptic vesicle retrieval
database_cross_reference: GOC:TermGenie

regulation of synaptic vesicle lumen acidification
type: Class
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle lumen acidification
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification.
created by: dsf
creation date: 2012-10-26T16:09:24Z
has_exact_synonym: regulation of synaptic vesicle lumen pH reduction
has_exact_synonym: regulation of synaptic vesicle lumen proton loading
has_obo_namespace: biological_process
id: GO:1901546
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle lumen acidification
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: regulation of synaptic vesicle lumen acidification
annotated property: has_exact_synonym
annotated target: regulation of synaptic vesicle lumen pH reduction
database_cross_reference: GOC:TermGenie

Axiom
annotated source: regulation of synaptic vesicle lumen acidification
annotated property: has_exact_synonym
annotated target: regulation of synaptic vesicle lumen proton loading
has_synonym_type: label approved by the SynGO project

regulation of anterograde synaptic vesicle transport
type: Class
subclass of: Restriction
  on property: regulates
  some values from: anterograde synaptic vesicle transport
definition: Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
created by: kmv
creation date: 2014-12-12T16:28:27Z
has_obo_namespace: biological_process
id: GO:1903742
in_subset: goslim synapse

Axiom
annotated source: regulation of anterograde synaptic vesicle transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:kmv
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:25329901

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
definition: Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
created by: dos
creation date: 2015-06-10T18:02:07Z
has_broad_synonym: transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
has_narrow_synonym: ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential
has_narrow_synonym: ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
has_obo_namespace: molecular_function
id: GO:1904315
in_subset: goslim synapse

Axiom
annotated source: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:20200227

Axiom
annotated source: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_narrow_synonym
annotated target: ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential
database_cross_reference: GOC:TermGenie

Axiom
annotated source: transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_narrow_synonym
annotated target: ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
database_cross_reference: GOC:TermGenie

voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic membrane potential
definition: Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
term tracker item: https://github.com/geneontology/go-ontology/issues/24479
created by: dos
creation date: 2016-03-04T15:51:54Z
has_broad_synonym: voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
has_exact_synonym: voltage gated ion channel activity involved in regulation of post-synaptic membrane potential
has_exact_synonym: voltage gated ion channel activity involved in regulation of postsynaptic membrane potential
has_exact_synonym: voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential
has_exact_synonym: voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential
has_exact_synonym: voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential
has_obo_namespace: molecular_function
id: GO:1905030
in_subset: goslim synapse

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: definition
annotated target: Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: ISBN:9780071120005

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_exact_synonym
annotated target: voltage gated ion channel activity involved in regulation of post-synaptic membrane potential
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_exact_synonym
annotated target: voltage gated ion channel activity involved in regulation of postsynaptic membrane potential
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_exact_synonym
annotated target: voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_exact_synonym
annotated target: voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
annotated property: has_exact_synonym
annotated target: voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential
database_cross_reference: GOC:TermGenie

calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
definition: Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-17T12:12:53Z
has_exact_synonym: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:1905054
in_subset: goslim synapse

Axiom
annotated source: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:15919193
database_cross_reference: PMID:23918386

Axiom
annotated source: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
definition: Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-17T14:35:35Z
has_broad_synonym: calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:1905055
in_subset: goslim synapse

Axiom
annotated source: calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:22972962
database_cross_reference: PMID:23255722

Axiom
annotated source: calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of presynaptic cytosolic calcium ion concentration
definition: A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-17T14:35:25Z
has_exact_synonym: ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
has_exact_synonym: Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_narrow_synonym: calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration
has_narrow_synonym: calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
has_narrow_synonym: calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
has_narrow_synonym: plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
has_obo_namespace: molecular_function
id: GO:1905056
in_subset: goslim synapse

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:22972962

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
type: Class
subclass of: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
definition: Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-18T12:31:48Z
has_exact_synonym: depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
has_exact_synonym: voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_obo_namespace: molecular_function
id: GO:1905057
in_subset: goslim synapse

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: definition
annotated target: Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:20734177

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_exact_synonym
annotated target: voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
annotated property: has_narrow_synonym
annotated target: dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
definition: Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-18T12:31:59Z
has_exact_synonym: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels
has_obo_namespace: molecular_function
id: GO:1905058
in_subset: goslim synapse

Axiom
annotated source: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:23639769

Axiom
annotated source: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
definition: A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-18T12:32:08Z
has_exact_synonym: ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
has_exact_synonym: Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels
has_narrow_synonym: calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
has_narrow_synonym: sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
has_obo_namespace: molecular_function
id: GO:1905059
in_subset: goslim synapse

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:20678993

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels
has_synonym_type: label approved by the SynGO project

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

Axiom
annotated source: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_narrow_synonym
annotated target: sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
database_cross_reference: GOC:TermGenie

calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of postsynaptic cytosolic calcium ion concentration
definition: Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
created by: dos
creation date: 2016-03-18T12:32:17Z
has_broad_synonym: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
has_exact_synonym: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
has_obo_namespace: molecular_function
id: GO:1905060
in_subset: goslim synapse

Axiom
annotated source: calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: definition
annotated target: Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000061
database_cross_reference: PMID:18024055

Axiom
annotated source: calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
annotated property: has_exact_synonym
annotated target: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
has_synonym_type: label approved by the SynGO project

regulation of modification of synaptic structure
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: modification of synaptic structure
definition: Any process that modulates the frequency, rate or extent of modification of synaptic structure.
created by: dos
creation date: 2016-06-09T09:43:40Z
has_exact_synonym: regulation of synapse remodelling
has_obo_namespace: biological_process
id: GO:1905244
in_subset: goslim synapse

Axiom
annotated source: regulation of modification of synaptic structure
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of modification of synaptic structure.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:25164660

Axiom
annotated source: regulation of modification of synaptic structure
annotated property: has_exact_synonym
annotated target: regulation of synapse remodelling
database_cross_reference: GOC:TermGenie

regulation of modification of postsynaptic actin cytoskeleton
type: Class
subclass of: regulation of modification of postsynaptic structure
subclass of: Restriction
  on property: regulates
  some values from: modification of postsynaptic actin cytoskeleton
definition: Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
created by: dos
creation date: 2016-06-16T22:34:25Z
has_exact_synonym: regulation of postsynaptic actin cytoskeleton remodelling
has_obo_namespace: biological_process
id: GO:1905274
in_subset: goslim synapse

Axiom
annotated source: regulation of modification of postsynaptic actin cytoskeleton
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:21068295

Axiom
annotated source: regulation of modification of postsynaptic actin cytoskeleton
annotated property: has_exact_synonym
annotated target: regulation of postsynaptic actin cytoskeleton remodelling
database_cross_reference: GOC:TermGenie

regulation of postsynapse to nucleus signaling pathway
type: Class
subclass of: Restriction
  on property: regulates
  some values from: postsynapse to nucleus signaling pathway
definition: Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.
created by: dos
creation date: 2016-10-07T17:03:38Z
has_exact_synonym: regulation of postsynaptic signaling to nucleus
has_obo_namespace: biological_process
id: GO:1905539
in_subset: goslim synapse

Axiom
annotated source: regulation of postsynapse to nucleus signaling pathway
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: ISBN:9780071120005

Axiom
annotated source: regulation of postsynapse to nucleus signaling pathway
annotated property: has_exact_synonym
annotated target: regulation of postsynaptic signaling to nucleus
database_cross_reference: GOC:TermGenie

regulation of presynapse assembly
type: Class
subclass of: regulation of synapse assembly
subclass of: regulation of presynapse organization
subclass of: Restriction
  on property: regulates
  some values from: presynapse assembly
definition: Any process that modulates the frequency, rate or extent of presynapse assembly.
created by: bc
creation date: 2016-10-27T16:08:13Z
has_exact_synonym: regulation of presynapse biogenesis
has_exact_synonym: regulation of presynaptic terminal assembly
has_obo_namespace: biological_process
id: GO:1905606
in_subset: goslim synapse

Axiom
annotated source: regulation of presynapse assembly
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of presynapse assembly.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:bc
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:25533483

Axiom
annotated source: regulation of presynapse assembly
annotated property: has_exact_synonym
annotated target: regulation of presynapse biogenesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: regulation of presynapse assembly
annotated property: has_exact_synonym
annotated target: regulation of presynaptic terminal assembly
database_cross_reference: GOC:TermGenie

calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
type: Class
subclass of: Restriction
  on property: part of
  some values from: negative regulation of presynaptic cytosolic calcium concentration
definition: Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration.
created by: dos
creation date: 2016-12-06T10:53:17Z
has_exact_synonym: calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
has_exact_synonym: mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration
has_obo_namespace: biological_process
id: GO:1905743
in_subset: goslim synapse

Axiom
annotated source: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
annotated property: definition
annotated target: Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000060
database_cross_reference: PMID:26644474

Axiom
annotated source: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
annotated property: has_exact_synonym
annotated target: calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
database_cross_reference: GOC:TermGenie

regulation of synapse pruning
type: Class
subclass of: regulation of synapse organization
subclass of: Restriction
  on property: regulates
  some values from: synapse pruning
definition: Any process that modulates the frequency, rate or extent of synapse pruning.
created by: tb
creation date: 2017-01-11T22:03:15Z
has_exact_synonym: regulation of synapse clearance
has_exact_synonym: regulation of synapse disassembly
has_exact_synonym: regulation of synapse elimination
has_exact_synonym: regulation of synapse removal
has_obo_namespace: biological_process
id: GO:1905806
in_subset: goslim synapse

Axiom
annotated source: regulation of synapse pruning
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synapse pruning.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:27779093

Axiom
annotated source: regulation of synapse pruning
annotated property: has_exact_synonym
annotated target: regulation of synapse disassembly
has_synonym_type: label approved by the SynGO project

anterograde neuronal dense core vesicle transport
type: Class
subclass of: anterograde axonal transport
definition: The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
has_exact_synonym: anterograde dense core granule trafficking
has_exact_synonym: anterograde dense core granule transport
has_obo_namespace: biological_process
id: GO:1990048
in_subset: goslim synapse

Axiom
annotated source: anterograde neuronal dense core vesicle transport
annotated property: definition
annotated target: The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
database_cross_reference: GOC:kmv
database_cross_reference: PMID:23358451

retrograde neuronal dense core vesicle transport
type: Class
subclass of: retrograde axonal transport
definition: The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
created by: pr
creation date: 2013-02-19T13:31:44Z
has_exact_synonym: retrograde dense core granule trafficking
has_exact_synonym: retrograde dense core granule transport
has_obo_namespace: biological_process
id: GO:1990049
in_subset: goslim synapse

Axiom
annotated source: retrograde neuronal dense core vesicle transport
annotated property: definition
annotated target: The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
database_cross_reference: GOC:kmv
database_cross_reference: PMID:23358451
database_cross_reference: PMID:24762653

regulation of synaptic vesicle exocytosis
type: Class
subclass of: modulation of chemical synaptic transmission
subclass of: Restriction
  on property: regulates
  some values from: neurotransmitter secretion
subclass of: Restriction
  on property: regulates
  some values from: synaptic vesicle exocytosis
definition: Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
created by: dph
creation date: 2011-01-03T08:20:40Z
has_obo_namespace: biological_process
id: GO:2000300
in_subset: goslim synapse

Axiom
annotated source: regulation of synaptic vesicle exocytosis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
database_cross_reference: GOC:obol

preceded by
database_cross_reference: BFO:0000062
has_obo_namespace: external
id: preceded_by
shorthand: preceded_by

precedes
database_cross_reference: BFO:0000063
has_obo_namespace: external
id: precedes
shorthand: precedes

results in
created by: cjm
creation date: 2012-03-14T10:35:44Z
database_cross_reference: GOREL:0000040
has_obo_namespace: external
id: results_in
shorthand: results_in
comment: This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.

results in division of
database_cross_reference: GOREL:0001019
has_obo_namespace: external
id: results_in_division_of
shorthand: results_in_division_of
comment: use occurs_in

results in distribution of
database_cross_reference: GOREL:0002003
has_obo_namespace: external
id: results_in_distribution_of
shorthand: results_in_distribution_of

results in fission of
database_cross_reference: GOREL:0002004
has_obo_namespace: external
id: results_in_fission_of
shorthand: results_in_fission_of

results in maintenance of
database_cross_reference: GOREL:0012006
has_obo_namespace: external
id: results_in_maintenance_of
shorthand: results_in_maintenance_of

bearer of
database_cross_reference: RO:0000053
has_obo_namespace: external
id: bearer_of
shorthand: bearer_of

participates in
database_cross_reference: RO:0000056
has_obo_namespace: external
id: participates_in
shorthand: participates_in

has participant
database_cross_reference: RO:0000057
has_obo_namespace: external
id: has_participant
shorthand: has_participant

bounding layer of
database_cross_reference: RO:0002007
has_obo_namespace: external
id: bounding_layer_of
shorthand: bounding_layer_of

coincident with
database_cross_reference: RO:0002008
has_obo_namespace: external
id: coincident_with
shorthand: coincident_with

regulates in other organism
database_cross_reference: RO:0002010
has_obo_namespace: external
id: regulates_in_other_organism
shorthand: regulates_in_other_organism

has regulatory component activity
database_cross_reference: RO:0002013
has_obo_namespace: external
id: has_regulatory_component_activity
shorthand: has_regulatory_component_activity

has negative regulatory component activity
database_cross_reference: RO:0002014
has_obo_namespace: external
id: has_negative_regulatory_component_activity
shorthand: has_negative_regulatory_component_activity

has necessary component activity
database_cross_reference: RO:0002016
has_obo_namespace: external
id: has_necessary_component_activity
shorthand: has_necessary_component_activity

immediately preceded by
database_cross_reference: RO:0002087
has_obo_namespace: external
id: immediately_preceded_by
shorthand: immediately_preceded_by

immediately precedes
database_cross_reference: RO:0002090
has_obo_namespace: external
id: immediately_precedes
shorthand: immediately_precedes

overlaps
database_cross_reference: RO:0002131
has_obo_namespace: external
id: overlaps
shorthand: overlaps

has component
database_cross_reference: RO:0002180
has_obo_namespace: external
id: has_component
shorthand: has_component

capable of
database_cross_reference: RO:0002215
has_obo_namespace: external
id: capable_of
shorthand: capable_of

capable of part of
database_cross_reference: RO:0002216
has_obo_namespace: external
id: capable_of_part_of
shorthand: capable_of_part_of

adjacent to
database_cross_reference: RO:0002220
has_obo_namespace: external
id: adjacent_to
shorthand: adjacent_to

starts with
database_cross_reference: RO:0002224
has_obo_namespace: external
id: starts_with
shorthand: starts_with

ends with
database_cross_reference: RO:0002230
has_obo_namespace: external
id: ends_with
shorthand: ends_with

has start location
database_cross_reference: RO:0002231
has_obo_namespace: external
id: has_start_location
shorthand: has_start_location

has end location
database_cross_reference: RO:0002232
has_obo_namespace: external
id: has_end_location
shorthand: has_end_location

has input
database_cross_reference: RO:0002233
has_obo_namespace: external
id: has_input
shorthand: has_input

has output
database_cross_reference: RO:0002234
has_obo_namespace: external
id: has_output
shorthand: has_output

results in developmental progression of
database_cross_reference: RO:0002295
has_obo_namespace: external
id: results_in_developmental_progression_of
shorthand: results_in_developmental_progression_of

results in development of
database_cross_reference: RO:0002296
has_obo_namespace: external
id: results_in_development_of
shorthand: results_in_development_of

results in formation of
database_cross_reference: RO:0002297
has_obo_namespace: external
id: results_in_formation_of
shorthand: results_in_formation_of

results in morphogenesis of
database_cross_reference: RO:0002298
has_obo_namespace: external
id: results_in_morphogenesis_of
shorthand: results_in_morphogenesis_of

results in maturation of
database_cross_reference: RO:0002299
has_obo_namespace: external
id: results_in_maturation_of
shorthand: results_in_maturation_of

causally upstream of, positive effect
database_cross_reference: RO:0002304
has_obo_namespace: external
id: causally_upstream_of,_positive_effect
shorthand: causally_upstream_of,_positive_effect

causally upstream of, negative effect
database_cross_reference: RO:0002305
has_obo_namespace: external
id: causally_upstream_of,_negative_effect
shorthand: causally_upstream_of,_negative_effect

results in acquisition of features of
database_cross_reference: RO:0002315
has_obo_namespace: external
id: results_in_acquisition_of_features_of
shorthand: results_in_acquisition_of_features_of

regulates levels of
database_cross_reference: RO:0002332
has_obo_namespace: external
id: regulates_levels_of
shorthand: regulates_levels_of

regulated by
database_cross_reference: RO:0002334
has_obo_namespace: external
id: regulated_by
shorthand: regulated_by

negatively regulated by
database_cross_reference: RO:0002335
has_obo_namespace: external
id: negatively_regulated_by
shorthand: negatively_regulated_by

positively regulated by
database_cross_reference: RO:0002336
has_obo_namespace: external
id: positively_regulated_by
shorthand: positively_regulated_by

has target start location
database_cross_reference: RO:0002338
has_obo_namespace: external
id: has_target_start_location
shorthand: has_target_start_location

has target end location
database_cross_reference: RO:0002339
has_obo_namespace: external
id: has_target_end_location
shorthand: has_target_end_location

results in transport along
database_cross_reference: RO:0002341
has_obo_namespace: external
id: results_in_transport_along
shorthand: results_in_transport_along

results in transport across
database_cross_reference: RO:0002342
has_obo_namespace: external
id: results_in_transport_across
shorthand: results_in_transport_across

results in growth of
database_cross_reference: RO:0002343
has_obo_namespace: external
id: results_in_growth_of
shorthand: results_in_growth_of

results in transport to from or in
database_cross_reference: RO:0002344
has_obo_namespace: external
id: results_in_transport_to_from_or_in
shorthand: results_in_transport_to_from_or_in

results in commitment to
database_cross_reference: RO:0002348
has_obo_namespace: external
id: results_in_commitment_to
shorthand: results_in_commitment_to

results in determination of
database_cross_reference: RO:0002349
has_obo_namespace: external
id: results_in_determination_of
shorthand: results_in_determination_of

output of
database_cross_reference: RO:0002353
has_obo_namespace: external
id: output_of
shorthand: output_of

results in structural organization of
database_cross_reference: RO:0002355
has_obo_namespace: external
id: results_in_structural_organization_of
shorthand: results_in_structural_organization_of

results in specification of
database_cross_reference: RO:0002356
has_obo_namespace: external
id: results_in_specification_of
shorthand: results_in_specification_of

causally downstream of
database_cross_reference: RO:0002404
has_obo_namespace: external
id: causally_downstream_of
shorthand: causally_downstream_of

immediately causally downstream of
database_cross_reference: RO:0002405
has_obo_namespace: external
id: immediately_causally_downstream_of
shorthand: immediately_causally_downstream_of

causally upstream of
database_cross_reference: RO:0002411
has_obo_namespace: external
id: causally_upstream_of
shorthand: causally_upstream_of

immediately causally upstream of
database_cross_reference: RO:0002412
has_obo_namespace: external
id: immediately_causally_upstream_of
shorthand: immediately_causally_upstream_of

causally upstream of or within
database_cross_reference: RO:0002418
has_obo_namespace: external
id: causally_upstream_of_or_within
shorthand: causally_upstream_of_or_within

causally downstream of or within
database_cross_reference: RO:0002427
has_obo_namespace: external
id: causally_downstream_of_or_within
shorthand: causally_downstream_of_or_within

has intermediate
database_cross_reference: RO:0002505
has_obo_namespace: external
id: has_intermediate
shorthand: has_intermediate

results in movement of
database_cross_reference: RO:0002565
has_obo_namespace: external
id: results_in_movement_of
shorthand: results_in_movement_of

directly regulates
database_cross_reference: RO:0002578
has_obo_namespace: external
id: directly_regulates
shorthand: directly_regulates

results in assembly of
database_cross_reference: RO:0002588
has_obo_namespace: external
id: results_in_assembly_of
shorthand: results_in_assembly_of

results in disassembly of
database_cross_reference: RO:0002590
has_obo_namespace: external
id: results_in_disassembly_of
shorthand: results_in_disassembly_of

results in remodeling of
database_cross_reference: RO:0002591
has_obo_namespace: external
id: results_in_remodeling_of
shorthand: results_in_remodeling_of

results in organization of
database_cross_reference: RO:0002592
has_obo_namespace: external
id: results_in_organization_of
shorthand: results_in_organization_of

process has causal agent
database_cross_reference: RO:0002608
has_obo_namespace: external
id: process_has_causal_agent
shorthand: process_has_causal_agent

directly positively regulates
database_cross_reference: RO:0002629
has_obo_namespace: external
id: directly_positively_regulates
shorthand: directly_positively_regulates

directly negatively regulates
database_cross_reference: RO:0002630
has_obo_namespace: external
id: directly_negatively_regulates
shorthand: directly_negatively_regulates

produces
database_cross_reference: RO:0003000
has_obo_namespace: external
id: produces
shorthand: produces

produced by
database_cross_reference: RO:0003001
has_obo_namespace: external
id: produced_by
shorthand: produced_by

has primary input or output
database_cross_reference: RO:0004007
has_obo_namespace: external
id: has_primary_input_or_output
shorthand: has_primary_input_or_output

has primary output
database_cross_reference: RO:0004008
has_obo_namespace: external
id: has_primary_output
shorthand: has_primary_output

has primary input
database_cross_reference: RO:0004009
has_obo_namespace: external
id: has_primary_input
shorthand: has_primary_input

has small molecule activator
database_cross_reference: RO:0012001
has_obo_namespace: external
id: has_small_molecule_activator
shorthand: has_small_molecule_activator

acts on population of
database_cross_reference: RO:0012003
has_obo_namespace: external
id: acts_on_population_of
shorthand: acts_on_population_of

results in fusion of
database_cross_reference: RO:0012008
has_obo_namespace: external
id: results_in_fusion_of
shorthand: results_in_fusion_of

regulates characteristic
database_cross_reference: RO:0019000
has_obo_namespace: gene_ontology
id: regulates_characteristic
shorthand: regulates_characteristic

positively regulates characteristic
database_cross_reference: RO:0019001
has_obo_namespace: gene_ontology
id: positively_regulates_characteristic
shorthand: positively_regulates_characteristic

negatively regulates characteristic
database_cross_reference: RO:0019002
has_obo_namespace: gene_ontology
id: negatively_regulates_characteristic
shorthand: negatively_regulates_characteristic

results in changes to anatomical or cellular structure
database_cross_reference: RO:0040036
has_obo_namespace: external
id: results_in_changes_to_anatomical_or_cellular_structure
shorthand: results_in_changes_to_anatomical_or_cellular_structure