{
  "summary": {
    "current": {
      "release_date": "2024-07-19",
      "valid_terms": 41404,
      "obsolete_terms": 6473,
      "merged_terms": 2436,
      "biological_process_terms": 26953,
      "molecular_function_terms": 10429,
      "cellular_component_terms": 4022,
      "meta_statements": 284769,
      "cross_references": 24583,
      "terms_relations": 82769
    },
    "previous": {
      "release_date": "2024-06-17",
      "valid_terms": 42093,
      "obsolete_terms": 5763,
      "merged_terms": 2436,
      "biological_process_terms": 26994,
      "molecular_function_terms": 11051,
      "cellular_component_terms": 4048,
      "meta_statements": 288028,
      "cross_references": 25491,
      "terms_relations": 83767
    },
    "changes": {
      "created_terms": 21,
      "valid_terms": -689,
      "obsolete_terms": 710,
      "merged_terms": 0,
      "biological_process_terms": -41,
      "molecular_function_terms": -622,
      "cellular_component_terms": -26,
      "meta_statements": 364,
      "meta_statements_by_term": 270,
      "cross_references": 779,
      "cross_references_by_term": 400,
      "relations": 547,
      "relations_by_term": 533
    }
  },
  "detailed_changes": {
    "created_terms": {
      "molecular_function": [
        {
          "id": "GO:0120514",
          "name": "2-hydroxyflavanone C-glucosyltransferase activity"
        },
        {
          "id": "GO:0120515",
          "name": "fatty acid-CoA ligase activity"
        },
        {
          "id": "GO:0120516",
          "name": "diacylglycerol lipase activity"
        },
        {
          "id": "GO:0120517",
          "name": "inositol pentakisphosphate kinase activity"
        },
        {
          "id": "GO:0120518",
          "name": "peptide-methionine-alpha-N-acetyltransferase activity"
        },
        {
          "id": "GO:0120519",
          "name": "tubulin N-terminal N-acetyltransferase activity"
        },
        {
          "id": "GO:0120520",
          "name": "free fatty acid 2-hydroxylase activity"
        },
        {
          "id": "GO:0120521",
          "name": "4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity"
        },
        {
          "id": "GO:0160190",
          "name": "peroxisome-mitochondrion membrane tether activity"
        },
        {
          "id": "GO:0160191",
          "name": "steroid 22S-hydroxylase activity"
        },
        {
          "id": "GO:0160193",
          "name": "L-lactate dehydrogenase inhibitor activity"
        },
        {
          "id": "GO:0180041",
          "name": "glycolipid 1,4-alpha-mannosyltransferase activity"
        },
        {
          "id": "GO:0180043",
          "name": "inositol pyrophosphate sensor activity"
        },
        {
          "id": "GO:0180044",
          "name": "borate channel activity"
        }
      ],
      "biological_process": [
        {
          "id": "GO:0141212",
          "name": "phospholipase C/protein kinase C signal transduction"
        },
        {
          "id": "GO:0141213",
          "name": "symbiont-mediated generation of symbiont replication vacuole"
        },
        {
          "id": "GO:0141214",
          "name": "positive regulation of phospholipase C/protein kinase C signal transduction"
        },
        {
          "id": "GO:0160192",
          "name": "autophagosome-dependent secretion"
        },
        {
          "id": "GO:0160194",
          "name": "stereocilium bundle organization"
        },
        {
          "id": "GO:0180042",
          "name": "polyphosphate import into vacuole"
        }
      ],
      "cellular_component": [
        {
          "id": "GO:0160189",
          "name": "peroxisomal-mitochondrial contact site"
        }
      ]
    },
    "obsolete_terms": {
      "cellular_component": [
        {
          "id": "GO:0000274",
          "name": "mitochondrial proton-transporting ATP synthase, stator stalk"
        },
        {
          "id": "GO:0000275",
          "name": "mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)"
        },
        {
          "id": "GO:0000276",
          "name": "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)"
        },
        {
          "id": "GO:0005746",
          "name": "mitochondrial respirasome"
        },
        {
          "id": "GO:0005750",
          "name": "mitochondrial respiratory chain complex III"
        },
        {
          "id": "GO:0005751",
          "name": "mitochondrial respiratory chain complex IV"
        },
        {
          "id": "GO:0005753",
          "name": "mitochondrial proton-transporting ATP synthase complex"
        },
        {
          "id": "GO:0005754",
          "name": "mitochondrial proton-transporting ATP synthase, catalytic core"
        },
        {
          "id": "GO:0005756",
          "name": "mitochondrial proton-transporting ATP synthase, central stalk"
        },
        {
          "id": "GO:0009544",
          "name": "chloroplast ATP synthase complex"
        },
        {
          "id": "GO:0030685",
          "name": "nucleolar preribosome"
        },
        {
          "id": "GO:0033174",
          "name": "chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)"
        },
        {
          "id": "GO:0033175",
          "name": "chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)"
        },
        {
          "id": "GO:0042652",
          "name": "mitochondrial respiratory chain complex I, peripheral segment"
        },
        {
          "id": "GO:0042653",
          "name": "mitochondrial respiratory chain complex I, membrane segment"
        },
        {
          "id": "GO:0045260",
          "name": "plasma membrane proton-transporting ATP synthase complex"
        },
        {
          "id": "GO:0045262",
          "name": "plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)"
        },
        {
          "id": "GO:0045264",
          "name": "plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)"
        },
        {
          "id": "GO:0045266",
          "name": "plasma membrane proton-transporting ATP synthase, stator stalk"
        },
        {
          "id": "GO:0045268",
          "name": "plasma membrane proton-transporting ATP synthase, catalytic core"
        },
        {
          "id": "GO:0045270",
          "name": "plasma membrane proton-transporting ATP synthase, central stalk"
        },
        {
          "id": "GO:0045276",
          "name": "plasma membrane respiratory chain complex III"
        },
        {
          "id": "GO:0045278",
          "name": "plasma membrane respiratory chain complex IV"
        },
        {
          "id": "GO:0045320",
          "name": "chloroplast proton-transporting ATP synthase complex"
        },
        {
          "id": "GO:0070469",
          "name": "respirasome"
        },
        {
          "id": "GO:0070470",
          "name": "plasma membrane respirasome"
        },
        {
          "id": "GO:1990124",
          "name": "messenger ribonucleoprotein complex"
        }
      ],
      "molecular_function": [
        {
          "id": "GO:0002083",
          "name": "4-hydroxybenzoate decaprenyltransferase activity"
        },
        {
          "id": "GO:0003721",
          "name": "telomerase RNA reverse transcriptase activity"
        },
        {
          "id": "GO:0004023",
          "name": "alcohol dehydrogenase (NAD+) activity, metal ion-independent"
        },
        {
          "id": "GO:0004024",
          "name": "alcohol dehydrogenase (NAD+) activity, zinc-dependent"
        },
        {
          "id": "GO:0004025",
          "name": "alcohol dehydrogenase (NAD+) activity, iron-dependent"
        },
        {
          "id": "GO:0004078",
          "name": "biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity"
        },
        {
          "id": "GO:0004079",
          "name": "biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity"
        },
        {
          "id": "GO:0004080",
          "name": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity"
        },
        {
          "id": "GO:0004085",
          "name": "butyryl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0004120",
          "name": "photoreceptor cyclic-nucleotide phosphodiesterase activity"
        },
        {
          "id": "GO:0004317",
          "name": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"
        },
        {
          "id": "GO:0004727",
          "name": "prenylated protein tyrosine phosphatase activity"
        },
        {
          "id": "GO:0008659",
          "name": "(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"
        },
        {
          "id": "GO:0008693",
          "name": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"
        },
        {
          "id": "GO:0008997",
          "name": "ribonuclease R activity"
        },
        {
          "id": "GO:0009974",
          "name": "zeinoxanthin epsilon hydroxylase activity"
        },
        {
          "id": "GO:0009979",
          "name": "16:0 monogalactosyldiacylglycerol desaturase activity"
        },
        {
          "id": "GO:0010857",
          "name": "calcium-dependent protein kinase activity"
        },
        {
          "id": "GO:0015475",
          "name": "adhesin autotransporter activity"
        },
        {
          "id": "GO:0015476",
          "name": "hemaglutinin autotransporter activity"
        },
        {
          "id": "GO:0016443",
          "name": "bidentate ribonuclease III activity"
        },
        {
          "id": "GO:0016897",
          "name": "RNA exonuclease activity, producing 3'-phosphomonoesters"
        },
        {
          "id": "GO:0016900",
          "name": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor"
        },
        {
          "id": "GO:0018071",
          "name": "NAD(P)-cysteine ADP-ribosyltransferase activity"
        },
        {
          "id": "GO:0018121",
          "name": "NAD(P)-asparagine ADP-ribosyltransferase activity"
        },
        {
          "id": "GO:0018127",
          "name": "NAD(P)-serine ADP-ribosyltransferase activity"
        },
        {
          "id": "GO:0018271",
          "name": "biotin-protein ligase activity"
        },
        {
          "id": "GO:0018446",
          "name": "pinocarveol dehydrogenase activity"
        },
        {
          "id": "GO:0018447",
          "name": "chloral hydrate dehydrogenase activity"
        },
        {
          "id": "GO:0018448",
          "name": "hydroxymethylmethylsilanediol oxidase activity"
        },
        {
          "id": "GO:0018450",
          "name": "myrtenol dehydrogenase activity"
        },
        {
          "id": "GO:0018451",
          "name": "epoxide dehydrogenase activity"
        },
        {
          "id": "GO:0018453",
          "name": "2-hydroxytetrahydrofuran dehydrogenase activity"
        },
        {
          "id": "GO:0018466",
          "name": "limonene-1,2-diol dehydrogenase activity"
        },
        {
          "id": "GO:0018469",
          "name": "myrtenal dehydrogenase activity"
        },
        {
          "id": "GO:0018470",
          "name": "4-hydroxybutaraldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0018471",
          "name": "4-chlorobenzaldehyde oxidase activity"
        },
        {
          "id": "GO:0018472",
          "name": "1-hydroxy-2-naphthaldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0018473",
          "name": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity"
        },
        {
          "id": "GO:0018475",
          "name": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity"
        },
        {
          "id": "GO:0018486",
          "name": "2-butanone oxidase activity"
        },
        {
          "id": "GO:0018487",
          "name": "vanillate O-demethylase (anaerobic) activity"
        },
        {
          "id": "GO:0018495",
          "name": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0018496",
          "name": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0018497",
          "name": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity"
        },
        {
          "id": "GO:0018499",
          "name": "cis-2,3-dihydrodiol DDT dehydrogenase activity"
        },
        {
          "id": "GO:0018500",
          "name": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity"
        },
        {
          "id": "GO:0018501",
          "name": "cis-chlorobenzene dihydrodiol dehydrogenase activity"
        },
        {
          "id": "GO:0018503",
          "name": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity"
        },
        {
          "id": "GO:0018524",
          "name": "acetophenone carboxylase activity"
        },
        {
          "id": "GO:0018526",
          "name": "2-aminobenzoyl-CoA reductase activity"
        },
        {
          "id": "GO:0018528",
          "name": "iminodiacetate dehydrogenase activity"
        },
        {
          "id": "GO:0018532",
          "name": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity"
        },
        {
          "id": "GO:0018534",
          "name": "nitrilotriacetate dehydrogenase activity"
        },
        {
          "id": "GO:0018542",
          "name": "2,3-dihydroxy DDT 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018547",
          "name": "nitroglycerin reductase activity"
        },
        {
          "id": "GO:0018548",
          "name": "pentaerythritol trinitrate reductase activity"
        },
        {
          "id": "GO:0018550",
          "name": "tetrachloro-p-hydroquinone reductive dehalogenase activity"
        },
        {
          "id": "GO:0018553",
          "name": "3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018555",
          "name": "phenanthrene dioxygenase activity"
        },
        {
          "id": "GO:0018556",
          "name": "2,2',3-trihydroxybiphenyl dioxygenase activity"
        },
        {
          "id": "GO:0018557",
          "name": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity"
        },
        {
          "id": "GO:0018558",
          "name": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity"
        },
        {
          "id": "GO:0018559",
          "name": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018560",
          "name": "protocatechuate 3,4-dioxygenase type II activity"
        },
        {
          "id": "GO:0018561",
          "name": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018562",
          "name": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity"
        },
        {
          "id": "GO:0018563",
          "name": "2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018565",
          "name": "dihydroxydibenzothiophene dioxygenase activity"
        },
        {
          "id": "GO:0018566",
          "name": "1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity"
        },
        {
          "id": "GO:0018567",
          "name": "styrene dioxygenase activity"
        },
        {
          "id": "GO:0018568",
          "name": "3,4-dihydroxyphenanthrene dioxygenase activity"
        },
        {
          "id": "GO:0018569",
          "name": "hydroquinone 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018572",
          "name": "3,5-dichlorocatechol 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018573",
          "name": "2-aminophenol 1,6-dioxygenase activity"
        },
        {
          "id": "GO:0018574",
          "name": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018575",
          "name": "chlorocatechol 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018584",
          "name": "2,4,5-trichlorophenoxyacetic acid oxygenase activity"
        },
        {
          "id": "GO:0018585",
          "name": "fluorene oxygenase activity"
        },
        {
          "id": "GO:0018586",
          "name": "mono-butyltin dioxygenase activity"
        },
        {
          "id": "GO:0018588",
          "name": "tri-n-butyltin dioxygenase activity"
        },
        {
          "id": "GO:0018589",
          "name": "di-n-butyltin dioxygenase activity"
        },
        {
          "id": "GO:0018590",
          "name": "methylsilanetriol hydroxylase activity"
        },
        {
          "id": "GO:0018593",
          "name": "4-chlorophenoxyacetate monooxygenase activity"
        },
        {
          "id": "GO:0018596",
          "name": "dimethylsilanediol hydroxylase activity"
        },
        {
          "id": "GO:0018598",
          "name": "hydroxymethylsilanetriol oxidase activity"
        },
        {
          "id": "GO:0018599",
          "name": "2-hydroxyisobutyrate 3-monooxygenase activity"
        },
        {
          "id": "GO:0018603",
          "name": "nitrobenzene 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018604",
          "name": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity"
        },
        {
          "id": "GO:0018606",
          "name": "benzenesulfonate dioxygenase activity"
        },
        {
          "id": "GO:0018607",
          "name": "1-indanone monooxygenase activity"
        },
        {
          "id": "GO:0018608",
          "name": "1-indanone dioxygenase activity"
        },
        {
          "id": "GO:0018609",
          "name": "chlorobenzene dioxygenase activity"
        },
        {
          "id": "GO:0018611",
          "name": "toluate dioxygenase activity"
        },
        {
          "id": "GO:0018612",
          "name": "dibenzothiophene dioxygenase activity"
        },
        {
          "id": "GO:0018613",
          "name": "9-fluorenone dioxygenase activity"
        },
        {
          "id": "GO:0018614",
          "name": "ethylbenzene dioxygenase activity"
        },
        {
          "id": "GO:0018615",
          "name": "2-indanone monooxygenase activity"
        },
        {
          "id": "GO:0018617",
          "name": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity"
        },
        {
          "id": "GO:0018630",
          "name": "3,5-xylenol methylhydroxylase activity"
        },
        {
          "id": "GO:0018636",
          "name": "phenanthrene 9,10-monooxygenase activity"
        },
        {
          "id": "GO:0018639",
          "name": "xylene monooxygenase activity"
        },
        {
          "id": "GO:0018641",
          "name": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity"
        },
        {
          "id": "GO:0018642",
          "name": "chlorophenol 4-monooxygenase activity"
        },
        {
          "id": "GO:0018643",
          "name": "carbon disulfide oxygenase activity"
        },
        {
          "id": "GO:0018646",
          "name": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity"
        },
        {
          "id": "GO:0018647",
          "name": "phenanthrene 1,2-monooxygenase activity"
        },
        {
          "id": "GO:0018649",
          "name": "tetrahydrofuran hydroxylase activity"
        },
        {
          "id": "GO:0018650",
          "name": "styrene monooxygenase activity"
        },
        {
          "id": "GO:0018651",
          "name": "toluene-4-sulfonate monooxygenase activity"
        },
        {
          "id": "GO:0018653",
          "name": "3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity"
        },
        {
          "id": "GO:0018654",
          "name": "2-hydroxy-phenylacetate hydroxylase activity"
        },
        {
          "id": "GO:0018655",
          "name": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity"
        },
        {
          "id": "GO:0018656",
          "name": "phenanthrene 3,4-monooxygenase activity"
        },
        {
          "id": "GO:0018680",
          "name": "deethylatrazine monooxygenase activity"
        },
        {
          "id": "GO:0018681",
          "name": "deisopropylatrazine monooxygenase activity"
        },
        {
          "id": "GO:0018682",
          "name": "atrazine N-dealkylase activity"
        },
        {
          "id": "GO:0018686",
          "name": "6-hydroxy pseudo-oxynicotine monooxygenase activity"
        },
        {
          "id": "GO:0018688",
          "name": "DDT 2,3-dioxygenase activity"
        },
        {
          "id": "GO:0018689",
          "name": "naphthalene disulfonate 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0018699",
          "name": "1,1,1-trichloroethane reductive dehalogenase activity"
        },
        {
          "id": "GO:0018700",
          "name": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity"
        },
        {
          "id": "GO:0018701",
          "name": "2,5-dichlorohydroquinone reductive dehalogenase activity"
        },
        {
          "id": "GO:0018702",
          "name": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity"
        },
        {
          "id": "GO:0018703",
          "name": "2,4-dichlorophenoxyacetate dehalogenase activity"
        },
        {
          "id": "GO:0018705",
          "name": "1,2-dichloroethene reductive dehalogenase activity"
        },
        {
          "id": "GO:0018707",
          "name": "1-phenanthrol methyltransferase activity"
        },
        {
          "id": "GO:0018715",
          "name": "9-phenanthrol UDP-glucuronosyltransferase activity"
        },
        {
          "id": "GO:0018716",
          "name": "1-phenanthrol glycosyltransferase activity"
        },
        {
          "id": "GO:0018717",
          "name": "9-phenanthrol glycosyltransferase activity"
        },
        {
          "id": "GO:0018718",
          "name": "1,2-dihydroxy-phenanthrene glycosyltransferase activity"
        },
        {
          "id": "GO:0018721",
          "name": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity"
        },
        {
          "id": "GO:0018722",
          "name": "1-phenanthrol sulfotransferase activity"
        },
        {
          "id": "GO:0018723",
          "name": "3-phenanthrol sulfotransferase activity"
        },
        {
          "id": "GO:0018724",
          "name": "4-phenanthrol sulfotransferase activity"
        },
        {
          "id": "GO:0018725",
          "name": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity"
        },
        {
          "id": "GO:0018726",
          "name": "9-phenanthrol sulfotransferase activity"
        },
        {
          "id": "GO:0018727",
          "name": "2-phenanthrol sulfotransferase activity"
        },
        {
          "id": "GO:0018731",
          "name": "1-oxa-2-oxocycloheptane lactonase activity"
        },
        {
          "id": "GO:0018732",
          "name": "sulfolactone hydrolase activity"
        },
        {
          "id": "GO:0018733",
          "name": "3,4-dihydrocoumarin hydrolase activity"
        },
        {
          "id": "GO:0018734",
          "name": "butyrolactone hydrolase activity"
        },
        {
          "id": "GO:0018736",
          "name": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity"
        },
        {
          "id": "GO:0018737",
          "name": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity"
        },
        {
          "id": "GO:0018742",
          "name": "epoxide hydrolase B activity"
        },
        {
          "id": "GO:0018743",
          "name": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity"
        },
        {
          "id": "GO:0018745",
          "name": "epoxide hydrolase A activity"
        },
        {
          "id": "GO:0018746",
          "name": "phenanthrene-3,4-epoxide hydrolase activity"
        },
        {
          "id": "GO:0018747",
          "name": "phenanthrene-1,2-epoxide hydrolase activity"
        },
        {
          "id": "GO:0018748",
          "name": "iprodione amidohydrolase activity"
        },
        {
          "id": "GO:0018749",
          "name": "(3,5-dichlorophenylurea)acetate amidohydrolase activity"
        },
        {
          "id": "GO:0018751",
          "name": "3,5-dichlorophenylcarboximide hydrolase activity"
        },
        {
          "id": "GO:0018758",
          "name": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity"
        },
        {
          "id": "GO:0018767",
          "name": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity"
        },
        {
          "id": "GO:0018769",
          "name": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity"
        },
        {
          "id": "GO:0018770",
          "name": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity"
        },
        {
          "id": "GO:0018776",
          "name": "trans-chloroacrylic acid dehalogenase activity"
        },
        {
          "id": "GO:0018777",
          "name": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity"
        },
        {
          "id": "GO:0018778",
          "name": "DL-2 haloacid dehalogenase activity"
        },
        {
          "id": "GO:0018780",
          "name": "dichloroacetate halidohydrolase activity"
        },
        {
          "id": "GO:0018781",
          "name": "S-triazine hydrolase activity"
        },
        {
          "id": "GO:0018782",
          "name": "cis-chloroacrylic acid dehalogenase activity"
        },
        {
          "id": "GO:0018783",
          "name": "deisopropyldeethylatrazine hydrolase activity"
        },
        {
          "id": "GO:0018791",
          "name": "2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity"
        },
        {
          "id": "GO:0018792",
          "name": "bis(4-chlorophenyl)acetate decarboxylase activity"
        },
        {
          "id": "GO:0018793",
          "name": "3,5-dibromo-4-hydroxybenzoate decarboxylase activity"
        },
        {
          "id": "GO:0018794",
          "name": "2-hydroxyisobutyrate decarboxylase activity"
        },
        {
          "id": "GO:0018795",
          "name": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity"
        },
        {
          "id": "GO:0018802",
          "name": "2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity"
        },
        {
          "id": "GO:0018808",
          "name": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity"
        },
        {
          "id": "GO:0018809",
          "name": "E-phenylitaconyl-CoA hydratase activity"
        },
        {
          "id": "GO:0018810",
          "name": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity"
        },
        {
          "id": "GO:0018816",
          "name": "2-hydroxyisobutyrate dehydratase activity"
        },
        {
          "id": "GO:0018825",
          "name": "triethanolamine lyase activity"
        },
        {
          "id": "GO:0018827",
          "name": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity"
        },
        {
          "id": "GO:0018828",
          "name": "halohydrin hydrogen-halide-lyase A activity"
        },
        {
          "id": "GO:0018829",
          "name": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity"
        },
        {
          "id": "GO:0018830",
          "name": "gamma-hexachlorocyclohexane dehydrochlorinase activity"
        },
        {
          "id": "GO:0018831",
          "name": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity"
        },
        {
          "id": "GO:0018832",
          "name": "halohydrin hydrogen-halide-lyase B activity"
        },
        {
          "id": "GO:0018837",
          "name": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity"
        },
        {
          "id": "GO:0018839",
          "name": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity"
        },
        {
          "id": "GO:0018844",
          "name": "2-hydroxytetrahydrofuran isomerase activity"
        },
        {
          "id": "GO:0018848",
          "name": "pinocarveol isomerase activity"
        },
        {
          "id": "GO:0018854",
          "name": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity"
        },
        {
          "id": "GO:0018857",
          "name": "2,4-dichlorobenzoate-CoA ligase activity"
        },
        {
          "id": "GO:0018863",
          "name": "phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity"
        },
        {
          "id": "GO:0030745",
          "name": "dimethylhistidine N-methyltransferase activity"
        },
        {
          "id": "GO:0030945",
          "name": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate"
        },
        {
          "id": "GO:0032450",
          "name": "maltose alpha-glucosidase activity"
        },
        {
          "id": "GO:0033201",
          "name": "alpha-1,4-glucan synthase activity"
        },
        {
          "id": "GO:0033250",
          "name": "penicillinase activity"
        },
        {
          "id": "GO:0033251",
          "name": "cephalosporinase activity"
        },
        {
          "id": "GO:0033824",
          "name": "alternansucrase activity"
        },
        {
          "id": "GO:0033898",
          "name": "Bacillus subtilis ribonuclease activity"
        },
        {
          "id": "GO:0034520",
          "name": "2-naphthaldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0034521",
          "name": "1-naphthoic acid dioxygenase activity"
        },
        {
          "id": "GO:0034522",
          "name": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity"
        },
        {
          "id": "GO:0034523",
          "name": "3-formylsalicylate oxidase activity"
        },
        {
          "id": "GO:0034524",
          "name": "2-hydroxyisophthalate decarboxylase activity"
        },
        {
          "id": "GO:0034525",
          "name": "1-naphthaldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0034526",
          "name": "2-methylnaphthalene hydroxylase activity"
        },
        {
          "id": "GO:0034527",
          "name": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity"
        },
        {
          "id": "GO:0034528",
          "name": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity"
        },
        {
          "id": "GO:0034529",
          "name": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity"
        },
        {
          "id": "GO:0034530",
          "name": "4-hydroxymethylsalicyaldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0034531",
          "name": "2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity"
        },
        {
          "id": "GO:0034532",
          "name": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity"
        },
        {
          "id": "GO:0034533",
          "name": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity"
        },
        {
          "id": "GO:0034534",
          "name": "1-methylnaphthalene hydroxylase activity"
        },
        {
          "id": "GO:0034535",
          "name": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity"
        },
        {
          "id": "GO:0034536",
          "name": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity"
        },
        {
          "id": "GO:0034537",
          "name": "2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity"
        },
        {
          "id": "GO:0034538",
          "name": "3-methylsalicylaldehyde dehydrogenase activity"
        },
        {
          "id": "GO:0034539",
          "name": "3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity"
        },
        {
          "id": "GO:0034540",
          "name": "3-monobromobisphenol A reductive dehalogenase activity"
        },
        {
          "id": "GO:0034541",
          "name": "dimethylarsinite methyltransferase activity"
        },
        {
          "id": "GO:0034542",
          "name": "trimethylarsine oxidase activity"
        },
        {
          "id": "GO:0034543",
          "name": "5-aminosalicylate dioxygenase activity"
        },
        {
          "id": "GO:0034544",
          "name": "trans-ACOHDA hydrolase activity"
        },
        {
          "id": "GO:0034546",
          "name": "2,4-dichloroaniline reductive dehalogenase activity"
        },
        {
          "id": "GO:0034550",
          "name": "dimethylarsinate reductase activity"
        },
        {
          "id": "GO:0034554",
          "name": "3,3',5-tribromobisphenol A reductive dehalogenase activity"
        },
        {
          "id": "GO:0034555",
          "name": "3,3'-dibromobisphenol A reductive dehalogenase activity"
        },
        {
          "id": "GO:0034556",
          "name": "nitrobenzoate nitroreductase activity"
        },
        {
          "id": "GO:0034558",
          "name": "technetium (VII) reductase activity"
        },
        {
          "id": "GO:0034559",
          "name": "bisphenol A hydroxylase B activity"
        },
        {
          "id": "GO:0034560",
          "name": "bisphenol A hydroxylase A activity"
        },
        {
          "id": "GO:0034561",
          "name": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity"
        },
        {
          "id": "GO:0034562",
          "name": "2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity"
        },
        {
          "id": "GO:0034563",
          "name": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity"
        },
        {
          "id": "GO:0034564",
          "name": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity"
        },
        {
          "id": "GO:0034565",
          "name": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity"
        },
        {
          "id": "GO:0034568",
          "name": "isoproturon dimethylaminedehydrogenase activity"
        },
        {
          "id": "GO:0034569",
          "name": "monodemethylisoproturon dehydrogenase activity"
        },
        {
          "id": "GO:0034570",
          "name": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity"
        },
        {
          "id": "GO:0034571",
          "name": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity"
        },
        {
          "id": "GO:0034572",
          "name": "monodemethylisoproturon dimethylaminedehydrogenase activity"
        },
        {
          "id": "GO:0034573",
          "name": "didemethylisoproturon amidohydrolase activity"
        },
        {
          "id": "GO:0034574",
          "name": "didemethylisoproturon dehydrogenase activity"
        },
        {
          "id": "GO:0034575",
          "name": "4-isopropylaniline dehydrogenase activity"
        },
        {
          "id": "GO:0034576",
          "name": "N-isopropylacetanilide amidohydrolase activity"
        },
        {
          "id": "GO:0034577",
          "name": "N-isopropylacetaniline monooxygenase activity"
        },
        {
          "id": "GO:0034578",
          "name": "limonene 8-hydratase activity"
        },
        {
          "id": "GO:0034579",
          "name": "(1-methylpentyl)succinate synthase activity"
        },
        {
          "id": "GO:0034580",
          "name": "4-methyloctanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034581",
          "name": "4-methyloct-2-enoyl-CoA hydratase activity"
        },
        {
          "id": "GO:0034582",
          "name": "3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034778",
          "name": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034779",
          "name": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity"
        },
        {
          "id": "GO:0034780",
          "name": "glyphosate dehydrogenase activity"
        },
        {
          "id": "GO:0034781",
          "name": "N-cyclohexylformamide amidohydrolase activity"
        },
        {
          "id": "GO:0034782",
          "name": "dimethylmalonate decarboxylase activity"
        },
        {
          "id": "GO:0034783",
          "name": "pivalate-CoA ligase activity"
        },
        {
          "id": "GO:0034786",
          "name": "9-fluorenone-3,4-dioxygenase activity"
        },
        {
          "id": "GO:0034787",
          "name": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity"
        },
        {
          "id": "GO:0034788",
          "name": "2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0034789",
          "name": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity"
        },
        {
          "id": "GO:0034790",
          "name": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity"
        },
        {
          "id": "GO:0034791",
          "name": "isobutylamine N-hydroxylase activity"
        },
        {
          "id": "GO:0034792",
          "name": "hypophosphite dioxygenase activity"
        },
        {
          "id": "GO:0034793",
          "name": "cyclopropanecarboxylate-CoA ligase activity"
        },
        {
          "id": "GO:0034794",
          "name": "cyclopropanecarboxyl-CoA decyclase activity"
        },
        {
          "id": "GO:0034795",
          "name": "cyclohexane monooxygenase activity"
        },
        {
          "id": "GO:0034796",
          "name": "adipate-CoA ligase activity"
        },
        {
          "id": "GO:0034797",
          "name": "fosfomycin 2-glutathione ligase activity"
        },
        {
          "id": "GO:0034798",
          "name": "fosfomycin 2-L-cysteine ligase activity"
        },
        {
          "id": "GO:0034799",
          "name": "dihydride TNP tautomerase activity"
        },
        {
          "id": "GO:0034800",
          "name": "trinitrophenol dihydride denitratase activity"
        },
        {
          "id": "GO:0034801",
          "name": "2,4-dinitrocyclohexanone hydrolase activity"
        },
        {
          "id": "GO:0034802",
          "name": "branched-chain dodecylbenzene sulfonate monooxygenase activity"
        },
        {
          "id": "GO:0034803",
          "name": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity"
        },
        {
          "id": "GO:0034804",
          "name": "benzo(a)pyrene 11,12-epoxidase activity"
        },
        {
          "id": "GO:0034805",
          "name": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity"
        },
        {
          "id": "GO:0034806",
          "name": "benzo(a)pyrene 11,12-dioxygenase activity"
        },
        {
          "id": "GO:0034807",
          "name": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity"
        },
        {
          "id": "GO:0034808",
          "name": "benzo(a)pyrene 4,5-dioxygenase activity"
        },
        {
          "id": "GO:0034809",
          "name": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity"
        },
        {
          "id": "GO:0034810",
          "name": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity"
        },
        {
          "id": "GO:0034811",
          "name": "benzo(a)pyrene 9,10-dioxygenase activity"
        },
        {
          "id": "GO:0034812",
          "name": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity"
        },
        {
          "id": "GO:0034813",
          "name": "benzo(a)pyrene 7,8-dioxygenase activity"
        },
        {
          "id": "GO:0034814",
          "name": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity"
        },
        {
          "id": "GO:0034815",
          "name": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity"
        },
        {
          "id": "GO:0034816",
          "name": "anthracene 9,10-dioxygenase activity"
        },
        {
          "id": "GO:0034817",
          "name": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity"
        },
        {
          "id": "GO:0034818",
          "name": "ADD 9alpha-hydroxylase activity"
        },
        {
          "id": "GO:0034819",
          "name": "3-HSA hydroxylase activity"
        },
        {
          "id": "GO:0034820",
          "name": "4,9-DSHA hydrolase activity"
        },
        {
          "id": "GO:0034821",
          "name": "citronellol dehydrogenase activity"
        },
        {
          "id": "GO:0034822",
          "name": "citronellal dehydrogenase activity"
        },
        {
          "id": "GO:0034825",
          "name": "tetralin ring-hydroxylating dioxygenase activity"
        },
        {
          "id": "GO:0034826",
          "name": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity"
        },
        {
          "id": "GO:0034827",
          "name": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity"
        },
        {
          "id": "GO:0034828",
          "name": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity"
        },
        {
          "id": "GO:0034829",
          "name": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity"
        },
        {
          "id": "GO:0034830",
          "name": "(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity"
        },
        {
          "id": "GO:0034831",
          "name": "(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity"
        },
        {
          "id": "GO:0034833",
          "name": "geranylate CoA-transferase activity"
        },
        {
          "id": "GO:0034834",
          "name": "2-mercaptobenzothiazole dioxygenase activity"
        },
        {
          "id": "GO:0034835",
          "name": "2-mercaptobenzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034836",
          "name": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034837",
          "name": "2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity"
        },
        {
          "id": "GO:0034838",
          "name": "menthone dehydrogenase activity"
        },
        {
          "id": "GO:0034839",
          "name": "menth-2-enone hydratase activity"
        },
        {
          "id": "GO:0034840",
          "name": "3-hydroxymenthone dehydrogenase activity"
        },
        {
          "id": "GO:0034841",
          "name": "mentha-1,3-dione-CoA ligase activity"
        },
        {
          "id": "GO:0034842",
          "name": "thiophene-2-carboxylate-CoA ligase activity"
        },
        {
          "id": "GO:0034843",
          "name": "2-oxoglutaryl-CoA thioesterase activity"
        },
        {
          "id": "GO:0034844",
          "name": "naphthyl-2-methyl-succinate CoA-transferase activity"
        },
        {
          "id": "GO:0034845",
          "name": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034846",
          "name": "naphthyl-2-methylene-succinyl-CoA lyase activity"
        },
        {
          "id": "GO:0034847",
          "name": "naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034848",
          "name": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity"
        },
        {
          "id": "GO:0034849",
          "name": "2-naphthoate CoA-transferase activity"
        },
        {
          "id": "GO:0034850",
          "name": "isooctane monooxygenase activity"
        },
        {
          "id": "GO:0034851",
          "name": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity"
        },
        {
          "id": "GO:0034852",
          "name": "4,4-dimethyl-3-oxopentanal dehydrogenase activity"
        },
        {
          "id": "GO:0034853",
          "name": "2,4,4-trimethyl-3-oxopentanoate decarboxylase activity"
        },
        {
          "id": "GO:0034854",
          "name": "4,4-dimethyl-3-oxopentanoate decarboxylase activity"
        },
        {
          "id": "GO:0034855",
          "name": "4-AD 9alpha-hydroxylase activity"
        },
        {
          "id": "GO:0034857",
          "name": "2-(methylthio)benzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034858",
          "name": "2-hydroxybenzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034859",
          "name": "benzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034860",
          "name": "2-mercaptobenzothiazole desulfurase activity"
        },
        {
          "id": "GO:0034861",
          "name": "benzothiazole-2-sulfonate hydrolase activity"
        },
        {
          "id": "GO:0034862",
          "name": "2,6-dihydroxybenzothiazole monooxygenase activity"
        },
        {
          "id": "GO:0034863",
          "name": "2,4,4-trimethyl-1-pentanol dehydrogenase activity"
        },
        {
          "id": "GO:0034864",
          "name": "2,4,4-trimethylpentanal dehydrogenase activity"
        },
        {
          "id": "GO:0034865",
          "name": "2,4,4-trimethylpentanoate-CoA ligase activity"
        },
        {
          "id": "GO:0034866",
          "name": "2,4,4-trimethylpentanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034867",
          "name": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity"
        },
        {
          "id": "GO:0034868",
          "name": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034869",
          "name": "2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity"
        },
        {
          "id": "GO:0034870",
          "name": "pinacolone 5-monooxygenase activity"
        },
        {
          "id": "GO:0034871",
          "name": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity"
        },
        {
          "id": "GO:0034872",
          "name": "trans-geranyl-CoA isomerase activity"
        },
        {
          "id": "GO:0034873",
          "name": "thioacetamide S-oxygenase activity"
        },
        {
          "id": "GO:0034874",
          "name": "thioacetamide S-oxide S-oxygenase activity"
        },
        {
          "id": "GO:0034876",
          "name": "isonicotinic acid hydrazide hydrolase activity"
        },
        {
          "id": "GO:0034877",
          "name": "isonicotinate dehydrogenase activity"
        },
        {
          "id": "GO:0034878",
          "name": "2-hydroxyisonicotinate dehydrogenase activity"
        },
        {
          "id": "GO:0034879",
          "name": "2,3,6-trihydroxyisonicotinate decarboxylase activity"
        },
        {
          "id": "GO:0034880",
          "name": "citrazinate dehydrogenase activity"
        },
        {
          "id": "GO:0034881",
          "name": "citrazinate hydrolase activity"
        },
        {
          "id": "GO:0034882",
          "name": "cis-aconitamide amidase activity"
        },
        {
          "id": "GO:0034885",
          "name": "gamma-N-formylaminovinylacetate hydrolase activity"
        },
        {
          "id": "GO:0034886",
          "name": "gamma-aminovinylacetate deaminase activity"
        },
        {
          "id": "GO:0034888",
          "name": "endosulfan monooxygenase I activity"
        },
        {
          "id": "GO:0034889",
          "name": "endosulfan hemisulfate sulfatase activity"
        },
        {
          "id": "GO:0034890",
          "name": "endosulfan diol hydrolyase (cyclizing) activity"
        },
        {
          "id": "GO:0034891",
          "name": "endosulfan diol dehydrogenase activity"
        },
        {
          "id": "GO:0034892",
          "name": "endosulfan lactone lactonase activity"
        },
        {
          "id": "GO:0034893",
          "name": "N-nitrodimethylamine hydroxylase activity"
        },
        {
          "id": "GO:0034894",
          "name": "4-hydroxypyridine-3-hydroxylase activity"
        },
        {
          "id": "GO:0034895",
          "name": "pyridine-3,4-diol dioxygenase activity"
        },
        {
          "id": "GO:0034896",
          "name": "3-formiminopyruvate hydrolase activity"
        },
        {
          "id": "GO:0034897",
          "name": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity"
        },
        {
          "id": "GO:0034898",
          "name": "hexadecyltrimethylammonium chloride monooxygenase activity"
        },
        {
          "id": "GO:0034900",
          "name": "3-(N-formyl)-formiminopyruvate hydrolase activity"
        },
        {
          "id": "GO:0034901",
          "name": "endosulfan hydroxyether dehydrogenase activity"
        },
        {
          "id": "GO:0034902",
          "name": "endosulfan sulfate hydrolase activity"
        },
        {
          "id": "GO:0034903",
          "name": "endosulfan ether monooxygenase activity"
        },
        {
          "id": "GO:0034904",
          "name": "5-chloro-2-oxopent-4-enoate hydratase activity"
        },
        {
          "id": "GO:0034905",
          "name": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity"
        },
        {
          "id": "GO:0034906",
          "name": "N-isopropylaniline 1,2-dixoxygenase activity"
        },
        {
          "id": "GO:0034907",
          "name": "acetanilide 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0034908",
          "name": "2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0034910",
          "name": "6-hydroxy-3-succinoylpyridine hydrolase activity"
        },
        {
          "id": "GO:0034911",
          "name": "phthalate 3,4-dioxygenase activity"
        },
        {
          "id": "GO:0034914",
          "name": "trinitrophenol hydride denitratase activity"
        },
        {
          "id": "GO:0034915",
          "name": "2-methylhexanoyl-CoA C-acetyltransferase activity"
        },
        {
          "id": "GO:0034916",
          "name": "2-methylhexanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034917",
          "name": "2-methylhex-2-enoyl-CoA hydratase activity"
        },
        {
          "id": "GO:0034918",
          "name": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034919",
          "name": "butyryl-CoA 2-C-propionyltransferase activity"
        },
        {
          "id": "GO:0034920",
          "name": "pyrene dioxygenase activity"
        },
        {
          "id": "GO:0034921",
          "name": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity"
        },
        {
          "id": "GO:0034922",
          "name": "4,5-dihydroxypyrene dioxygenase activity"
        },
        {
          "id": "GO:0034923",
          "name": "phenanthrene-4,5-dicarboxylate decarboxylase activity"
        },
        {
          "id": "GO:0034924",
          "name": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity"
        },
        {
          "id": "GO:0034925",
          "name": "pyrene 4,5-monooxygenase activity"
        },
        {
          "id": "GO:0034926",
          "name": "pyrene-4,5-epoxide hydrolase activity"
        },
        {
          "id": "GO:0034927",
          "name": "pyrene 1,2-monooxygenase activity"
        },
        {
          "id": "GO:0034928",
          "name": "1-hydroxypyrene 6,7-monooxygenase activity"
        },
        {
          "id": "GO:0034929",
          "name": "1-hydroxypyrene 7,8-monooxygenase activity"
        },
        {
          "id": "GO:0034930",
          "name": "1-hydroxypyrene sulfotransferase activity"
        },
        {
          "id": "GO:0034931",
          "name": "1-hydroxypyrene methyltransferase activity"
        },
        {
          "id": "GO:0034932",
          "name": "1-methoxypyrene 6,7-monooxygenase activity"
        },
        {
          "id": "GO:0034933",
          "name": "1-hydroxy-6-methoxypyrene methyltransferase activity"
        },
        {
          "id": "GO:0034934",
          "name": "phenanthrene-4-carboxylate dioxygenase activity"
        },
        {
          "id": "GO:0034935",
          "name": "tetrachlorobenzene dioxygenase activity"
        },
        {
          "id": "GO:0034936",
          "name": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0034937",
          "name": "perchlorate reductase activity"
        },
        {
          "id": "GO:0034939",
          "name": "5-hydroxypyrrole-2-carboxylate tautomerase activity"
        },
        {
          "id": "GO:0034940",
          "name": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity"
        },
        {
          "id": "GO:0034942",
          "name": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity"
        },
        {
          "id": "GO:0034943",
          "name": "trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity"
        },
        {
          "id": "GO:0034944",
          "name": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0034945",
          "name": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity"
        },
        {
          "id": "GO:0034946",
          "name": "3-isopropylbut-3-enoyl-CoA thioesterase activity"
        },
        {
          "id": "GO:0034947",
          "name": "terephthalate decarboxylase activity"
        },
        {
          "id": "GO:0034948",
          "name": "2,6-dihydroxypseudooxynicotine hydrolase activity"
        },
        {
          "id": "GO:0034949",
          "name": "1,1-dichloroethane reductive dehalogenase activity"
        },
        {
          "id": "GO:0034950",
          "name": "phenylboronic acid monooxygenase activity"
        },
        {
          "id": "GO:0034951",
          "name": "o-hydroxylaminobenzoate mutase activity"
        },
        {
          "id": "GO:0034952",
          "name": "malonate semialdehyde decarboxylase activity"
        },
        {
          "id": "GO:0034953",
          "name": "perillyl-CoA hydratase activity"
        },
        {
          "id": "GO:0034954",
          "name": "diphenyl ether 2,3-dioxygenase activity"
        },
        {
          "id": "GO:0034955",
          "name": "2,3-dihydroxydiphenyl ether dioxygenase activity"
        },
        {
          "id": "GO:0034956",
          "name": "diphenyl ether 1,2-dioxygenase activity"
        },
        {
          "id": "GO:0034957",
          "name": "3-nitrophenol nitroreductase activity"
        },
        {
          "id": "GO:0034958",
          "name": "aminohydroquinone monooxygenase activity"
        },
        {
          "id": "GO:0035049",
          "name": "juvenile hormone acid methyltransferase activity"
        },
        {
          "id": "GO:0036132",
          "name": "13-prostaglandin reductase activity"
        },
        {
          "id": "GO:0036136",
          "name": "kynurenine-oxaloacetate transaminase activity"
        },
        {
          "id": "GO:0036137",
          "name": "kynurenine aminotransferase activity"
        },
        {
          "id": "GO:0036141",
          "name": "L-phenylalanine-oxaloacetate transaminase activity"
        },
        {
          "id": "GO:0036357",
          "name": "2-phosphoglycerate kinase activity"
        },
        {
          "id": "GO:0043727",
          "name": "5-amino-4-imidazole carboxylate lyase activity"
        },
        {
          "id": "GO:0043728",
          "name": "2-keto-4-methylthiobutyrate aminotransferase activity"
        },
        {
          "id": "GO:0043749",
          "name": "phenol, water dikinase activity"
        },
        {
          "id": "GO:0043783",
          "name": "oxidoreductase activity, acting on metal ions, flavin as acceptor"
        },
        {
          "id": "GO:0043830",
          "name": "thiol-driven fumarate reductase activity"
        },
        {
          "id": "GO:0043840",
          "name": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity"
        },
        {
          "id": "GO:0043912",
          "name": "D-lysine oxidase activity"
        },
        {
          "id": "GO:0044019",
          "name": "histone H3K72 acetyltransferase activity"
        },
        {
          "id": "GO:0044318",
          "name": "L-aspartate:fumarate oxidoreductase activity"
        },
        {
          "id": "GO:0044653",
          "name": "dextrin alpha-glucosidase activity"
        },
        {
          "id": "GO:0044654",
          "name": "starch alpha-glucosidase activity"
        },
        {
          "id": "GO:0044685",
          "name": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity"
        },
        {
          "id": "GO:0046566",
          "name": "DOPA dioxygenase activity"
        },
        {
          "id": "GO:0046571",
          "name": "aspartate-2-keto-4-methylthiobutyrate transaminase activity"
        },
        {
          "id": "GO:0047217",
          "name": "sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity"
        },
        {
          "id": "GO:0047293",
          "name": "4-hydroxybenzoate nonaprenyltransferase activity"
        },
        {
          "id": "GO:0047450",
          "name": "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity"
        },
        {
          "id": "GO:0047451",
          "name": "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"
        },
        {
          "id": "GO:0050141",
          "name": "nitroethane oxidase activity"
        },
        {
          "id": "GO:0050522",
          "name": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors"
        },
        {
          "id": "GO:0051909",
          "name": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate"
        },
        {
          "id": "GO:0052580",
          "name": "(+)-pulegone reductase, (-)-menthone as substrate, activity"
        },
        {
          "id": "GO:0052585",
          "name": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor"
        },
        {
          "id": "GO:0052586",
          "name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor"
        },
        {
          "id": "GO:0052599",
          "name": "methylputrescine oxidase activity"
        },
        {
          "id": "GO:0052600",
          "name": "propane-1,3-diamine oxidase activity"
        },
        {
          "id": "GO:0052637",
          "name": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity"
        },
        {
          "id": "GO:0052665",
          "name": "tRNA (uracil-2'-O-)-methyltransferase activity"
        },
        {
          "id": "GO:0052667",
          "name": "phosphomethylethanolamine N-methyltransferase activity"
        },
        {
          "id": "GO:0052685",
          "name": "perillic acid-CoA ligase (ADP-forming) activity"
        },
        {
          "id": "GO:0052705",
          "name": "methylhistidine N-methyltransferase activity"
        },
        {
          "id": "GO:0052758",
          "name": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity"
        },
        {
          "id": "GO:0052759",
          "name": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity"
        },
        {
          "id": "GO:0052760",
          "name": "coenzyme F420-dependent 2,4-dinitrophenol reductase activity"
        },
        {
          "id": "GO:0052789",
          "name": "mannan 1,3-beta-mannosidase activity"
        },
        {
          "id": "GO:0052790",
          "name": "chitooligosaccharide deacetylase activity"
        },
        {
          "id": "GO:0052808",
          "name": "reduced coenzyme F420:NADP+ oxidoreductase activity"
        },
        {
          "id": "GO:0052818",
          "name": "heteroglycan 3-alpha-mannosyltransferase activity"
        },
        {
          "id": "GO:0052819",
          "name": "heteroglycan 2-alpha-mannosyltransferase activity"
        },
        {
          "id": "GO:0052858",
          "name": "peptidyl-lysine acetyltransferase activity"
        },
        {
          "id": "GO:0052862",
          "name": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group"
        },
        {
          "id": "GO:0052886",
          "name": "9,9'-dicis-carotene:quinone oxidoreductase activity"
        },
        {
          "id": "GO:0052887",
          "name": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity"
        },
        {
          "id": "GO:0070546",
          "name": "L-phenylalanine aminotransferase activity"
        },
        {
          "id": "GO:0070547",
          "name": "L-tyrosine aminotransferase activity"
        },
        {
          "id": "GO:0070774",
          "name": "phytoceramidase activity"
        },
        {
          "id": "GO:0071633",
          "name": "dihydroceramidase activity"
        },
        {
          "id": "GO:0071734",
          "name": "biotin-[pyruvate-carboxylase] ligase activity"
        },
        {
          "id": "GO:0072373",
          "name": "alpha-carotene epsilon hydroxylase activity"
        },
        {
          "id": "GO:0080101",
          "name": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity"
        },
        {
          "id": "GO:0090600",
          "name": "alpha-1,3-glucosidase activity"
        },
        {
          "id": "GO:0102027",
          "name": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"
        },
        {
          "id": "GO:0102035",
          "name": "2-methylpropanoyl-CoA dehydrogenase activity"
        },
        {
          "id": "GO:0102055",
          "name": "12-hydroxyjasmonate sulfotransferase activity"
        },
        {
          "id": "GO:0102056",
          "name": "11-hydroxyjasmonate sulfotransferase activity"
        },
        {
          "id": "GO:0102085",
          "name": "N-(4-aminobenzoyl)-L-glutamate synthetase activity"
        },
        {
          "id": "GO:0102086",
          "name": "N-vanillate-L-glutamate synthetase activity"
        },
        {
          "id": "GO:0102087",
          "name": "N-benzoyl-L-glutamate synthetase activity"
        },
        {
          "id": "GO:0102088",
          "name": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity"
        },
        {
          "id": "GO:0102090",
          "name": "adrenaline O-methyltransferase activity"
        },
        {
          "id": "GO:0102094",
          "name": "S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"
        },
        {
          "id": "GO:0102104",
          "name": "demethoxycurcumin synthase activity"
        },
        {
          "id": "GO:0102105",
          "name": "demethoxycurcumin synthase activity from feruloylacetyl-CoA"
        },
        {
          "id": "GO:0102121",
          "name": "ceramidase activity"
        },
        {
          "id": "GO:0102128",
          "name": "chalcone synthase activity"
        },
        {
          "id": "GO:0102137",
          "name": "7-oxateasterone synthase activity"
        },
        {
          "id": "GO:0102138",
          "name": "7-oxatyphasterol synthase activity"
        },
        {
          "id": "GO:0102139",
          "name": "2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity"
        },
        {
          "id": "GO:0102151",
          "name": "3-oxo-myristate decarboxylase activity"
        },
        {
          "id": "GO:0102154",
          "name": "8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity"
        },
        {
          "id": "GO:0102156",
          "name": "2,5-DHBA UDP-glucosyltransferase activity"
        },
        {
          "id": "GO:0102163",
          "name": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity"
        },
        {
          "id": "GO:0102253",
          "name": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity"
        },
        {
          "id": "GO:0102254",
          "name": "neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity"
        },
        {
          "id": "GO:0102256",
          "name": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity"
        },
        {
          "id": "GO:0102279",
          "name": "lecithin:11-cis retinol acyltransferase activity"
        },
        {
          "id": "GO:0102308",
          "name": "erythromycin D 3''-o-methyltransferase activity"
        },
        {
          "id": "GO:0102328",
          "name": "3-oxoacid decarboxylase activity"
        },
        {
          "id": "GO:0102359",
          "name": "daphnetin 4-O-beta-glucosyltransferase activity"
        },
        {
          "id": "GO:0102360",
          "name": "daphnetin 3-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102361",
          "name": "esculetin 4-O-beta-glucosyltransferase activity"
        },
        {
          "id": "GO:0102362",
          "name": "esculetin 3-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102366",
          "name": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity"
        },
        {
          "id": "GO:0102367",
          "name": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity"
        },
        {
          "id": "GO:0102383",
          "name": "steviol 19-O glucosyltransferase activity"
        },
        {
          "id": "GO:0102384",
          "name": "19-O-beta-glucopyranosyl-steviol glucosyltransferase activity"
        },
        {
          "id": "GO:0102387",
          "name": "2-phenylethanol acetyltransferase activity"
        },
        {
          "id": "GO:0102402",
          "name": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity"
        },
        {
          "id": "GO:0102404",
          "name": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity"
        },
        {
          "id": "GO:0102410",
          "name": "quercetin-4',3-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102411",
          "name": "quercetin-3,4'-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102414",
          "name": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102415",
          "name": "quercetin gentiobioside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102416",
          "name": "quercetin gentiotrioside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102417",
          "name": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102418",
          "name": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102420",
          "name": "sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"
        },
        {
          "id": "GO:0102421",
          "name": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102422",
          "name": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102424",
          "name": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102425",
          "name": "myricetin 3-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102426",
          "name": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102428",
          "name": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102429",
          "name": "genistein-3-O-glucoside 1,6-glucosyltransferase activity"
        },
        {
          "id": "GO:0102456",
          "name": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102458",
          "name": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102460",
          "name": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102461",
          "name": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102462",
          "name": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102463",
          "name": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102470",
          "name": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity"
        },
        {
          "id": "GO:0102473",
          "name": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity"
        },
        {
          "id": "GO:0102474",
          "name": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity"
        },
        {
          "id": "GO:0102480",
          "name": "5-fluorocytosine deaminase activity"
        },
        {
          "id": "GO:0102484",
          "name": "esculetin glucosyltransferase activity"
        },
        {
          "id": "GO:0102493",
          "name": "wogonin 7-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102498",
          "name": "maltose glucosidase activity"
        },
        {
          "id": "GO:0102500",
          "name": "beta-maltose 4-alpha-glucanotransferase activity"
        },
        {
          "id": "GO:0102502",
          "name": "ADP-glucose-starch glucosyltransferase activity"
        },
        {
          "id": "GO:0102504",
          "name": "luteolinidin 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102505",
          "name": "apigeninidin 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102507",
          "name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity"
        },
        {
          "id": "GO:0102510",
          "name": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102511",
          "name": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102512",
          "name": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102513",
          "name": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102514",
          "name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102515",
          "name": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102516",
          "name": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102560",
          "name": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity"
        },
        {
          "id": "GO:0102562",
          "name": "hydroxyproline O-arbinofuranose transferase activity"
        },
        {
          "id": "GO:0102577",
          "name": "3-oxo-palmitate decarboxylase activity"
        },
        {
          "id": "GO:0102584",
          "name": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102587",
          "name": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity"
        },
        {
          "id": "GO:0102588",
          "name": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity"
        },
        {
          "id": "GO:0102590",
          "name": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity"
        },
        {
          "id": "GO:0102593",
          "name": "UDP-glucose"
        },
        {
          "id": "GO:0102638",
          "name": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity"
        },
        {
          "id": "GO:0102659",
          "name": "UDP-glucose"
        },
        {
          "id": "GO:0102669",
          "name": "isoflavone-7-O-glucoside beta-glucosidase activity"
        },
        {
          "id": "GO:0102677",
          "name": "campesterol,NADPH:oxygen oxidoreductase activity"
        },
        {
          "id": "GO:0102685",
          "name": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102686",
          "name": "UDP-glucose:trans-zeatin 9-N-glucosyltransferase"
        },
        {
          "id": "GO:0102687",
          "name": "UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102688",
          "name": "dihydrozeatin UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102689",
          "name": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102690",
          "name": "isopentenyladenine UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102691",
          "name": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102692",
          "name": "benzyladenine UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102693",
          "name": "UDP-glucose:kinetin 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102694",
          "name": "kinetin UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102695",
          "name": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity"
        },
        {
          "id": "GO:0102696",
          "name": "cis-zeatin UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102697",
          "name": "trans-zeatin-O-glucoside UDP glycosyltransferase activity"
        },
        {
          "id": "GO:0102707",
          "name": "S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity"
        },
        {
          "id": "GO:0102723",
          "name": "UDP-glucose:curcumin glucosyltransferase activity"
        },
        {
          "id": "GO:0102724",
          "name": "UDP-glucose:curcumin monoglucoside glucosyltransferase activity"
        },
        {
          "id": "GO:0102729",
          "name": "6-oxocampestanol hydroxylase activity"
        },
        {
          "id": "GO:0102740",
          "name": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity"
        },
        {
          "id": "GO:0102751",
          "name": "UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity"
        },
        {
          "id": "GO:0102752",
          "name": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"
        },
        {
          "id": "GO:0102759",
          "name": "campestanol hydroxylase activity"
        },
        {
          "id": "GO:0102760",
          "name": "6-deoxocathasterone hydroxylase activity"
        },
        {
          "id": "GO:0102776",
          "name": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102777",
          "name": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity"
        },
        {
          "id": "GO:0102780",
          "name": "sitosterol hydroxylase activity"
        },
        {
          "id": "GO:0102789",
          "name": "UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity"
        },
        {
          "id": "GO:0102790",
          "name": "cyanidin 5,3-O-glycosyltransferase activity"
        },
        {
          "id": "GO:0102807",
          "name": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102808",
          "name": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102809",
          "name": "delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102813",
          "name": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102815",
          "name": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity"
        },
        {
          "id": "GO:0102823",
          "name": "kaempferol-3-rhamnoside-glucosyltransferase activity"
        },
        {
          "id": "GO:0102824",
          "name": "UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102825",
          "name": "quercetin 3-O-rhamnoside-glucosyltransferase activity"
        },
        {
          "id": "GO:0102826",
          "name": "kaempferol-3-glucoside-glucosyltransferase activity"
        },
        {
          "id": "GO:0102828",
          "name": "stachyose galactinol:verbascose galactosyltransferase activity"
        },
        {
          "id": "GO:0102829",
          "name": "ajugose synthase activity"
        },
        {
          "id": "GO:0102833",
          "name": "sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity"
        },
        {
          "id": "GO:0102869",
          "name": "6-hydroxyflavone-glucosyltransferase activity"
        },
        {
          "id": "GO:0102870",
          "name": "7-hydroxyflavone-glucosyltransferase activity"
        },
        {
          "id": "GO:0102891",
          "name": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102892",
          "name": "betanidin 5-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102893",
          "name": "betanidin 6-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0102918",
          "name": "(R)-reticuline 7-O-methyltransferase activity"
        },
        {
          "id": "GO:0102920",
          "name": "acyl coenzyme A"
        },
        {
          "id": "GO:0102927",
          "name": "beta-chaconine rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102928",
          "name": "beta-solanine rhamnosyltransferase activity"
        },
        {
          "id": "GO:0102935",
          "name": "gypsogenin-UDP-glucosyltransferase activity"
        },
        {
          "id": "GO:0102936",
          "name": "gypsogenate-UDP-glucosyltransferase activity"
        },
        {
          "id": "GO:0102944",
          "name": "medicagenate UDP-glucosyltransferase activity"
        },
        {
          "id": "GO:0102945",
          "name": "soyasapogenol B UDP-glucosyl transferase activity"
        },
        {
          "id": "GO:0102946",
          "name": "soyasapogenol E UDP-glucosyltransferase activity"
        },
        {
          "id": "GO:0102948",
          "name": "luteolin C-glucosyltransferase activity"
        },
        {
          "id": "GO:0102952",
          "name": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity"
        },
        {
          "id": "GO:0102955",
          "name": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"
        },
        {
          "id": "GO:0102956",
          "name": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity"
        },
        {
          "id": "GO:0102996",
          "name": "beta,beta digalactosyldiacylglycerol galactosyltransferase activity"
        },
        {
          "id": "GO:0102999",
          "name": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0103000",
          "name": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0103047",
          "name": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity"
        },
        {
          "id": "GO:0103058",
          "name": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0103059",
          "name": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0103060",
          "name": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0103077",
          "name": "quercetin 3-glucoside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0103078",
          "name": "quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity"
        },
        {
          "id": "GO:0103099",
          "name": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity"
        },
        {
          "id": "GO:0103100",
          "name": "UDP-glucose"
        },
        {
          "id": "GO:0103101",
          "name": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity"
        },
        {
          "id": "GO:0103102",
          "name": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity"
        },
        {
          "id": "GO:0103103",
          "name": "UDP-glucose"
        },
        {
          "id": "GO:0103106",
          "name": "brassinolide 23-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0103107",
          "name": "castasterone 23-O-glucosyltransferase activity"
        },
        {
          "id": "GO:0106325",
          "name": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"
        },
        {
          "id": "GO:0106326",
          "name": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity"
        },
        {
          "id": "GO:0140868",
          "name": "4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)"
        }
      ],
      "biological_process": [
        {
          "id": "GO:0006539",
          "name": "glutamate catabolic process via 2-oxoglutarate"
        },
        {
          "id": "GO:0007205",
          "name": "protein kinase C-activating G protein-coupled receptor signaling pathway"
        },
        {
          "id": "GO:0010243",
          "name": "response to organonitrogen compound"
        },
        {
          "id": "GO:0018265",
          "name": "GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018266",
          "name": "GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018267",
          "name": "GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018268",
          "name": "GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018269",
          "name": "GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018270",
          "name": "GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0018865",
          "name": "acrylonitrile metabolic process"
        },
        {
          "id": "GO:0018912",
          "name": "1,4-dichlorobenzene metabolic process"
        },
        {
          "id": "GO:0018913",
          "name": "anaerobic ethylbenzene metabolic process"
        },
        {
          "id": "GO:0018967",
          "name": "tetrachloroethylene metabolic process"
        },
        {
          "id": "GO:0019389",
          "name": "glucuronoside metabolic process"
        },
        {
          "id": "GO:0019390",
          "name": "glucuronoside biosynthetic process"
        },
        {
          "id": "GO:0019391",
          "name": "glucuronoside catabolic process"
        },
        {
          "id": "GO:0019460",
          "name": "glutamine catabolic process to fumarate"
        },
        {
          "id": "GO:0019461",
          "name": "glutamine catabolic process to fumarate, using glutamate synthase (NADPH)"
        },
        {
          "id": "GO:0019462",
          "name": "glutamine catabolic process to fumarate, using glutaminase"
        },
        {
          "id": "GO:0019468",
          "name": "nopaline catabolic process"
        },
        {
          "id": "GO:0019469",
          "name": "octopine catabolic process"
        },
        {
          "id": "GO:0019516",
          "name": "lactate oxidation"
        },
        {
          "id": "GO:0019549",
          "name": "glutamate catabolic process to succinate via succinate semialdehyde"
        },
        {
          "id": "GO:0019671",
          "name": "glutamate catabolic process via mesaconate and citramalate"
        },
        {
          "id": "GO:0033253",
          "name": "regulation of penicillinase activity"
        },
        {
          "id": "GO:0035593",
          "name": "positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region"
        },
        {
          "id": "GO:0036242",
          "name": "glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity"
        },
        {
          "id": "GO:0042458",
          "name": "nopaline catabolic process to proline"
        },
        {
          "id": "GO:0042459",
          "name": "octopine catabolic process to proline"
        },
        {
          "id": "GO:0046418",
          "name": "nopaline metabolic process"
        },
        {
          "id": "GO:0046419",
          "name": "octopine metabolic process"
        },
        {
          "id": "GO:0050493",
          "name": "GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine"
        },
        {
          "id": "GO:0051972",
          "name": "regulation of telomerase activity"
        },
        {
          "id": "GO:0051973",
          "name": "positive regulation of telomerase activity"
        },
        {
          "id": "GO:0051974",
          "name": "negative regulation of telomerase activity"
        },
        {
          "id": "GO:0052707",
          "name": "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine"
        },
        {
          "id": "GO:0071417",
          "name": "cellular response to organonitrogen compound"
        },
        {
          "id": "GO:0141078",
          "name": "symbiont-mediated suppression of host RIG-I signaling pathway"
        },
        {
          "id": "GO:1901564",
          "name": "organonitrogen compound metabolic process"
        },
        {
          "id": "GO:1901565",
          "name": "organonitrogen compound catabolic process"
        },
        {
          "id": "GO:1901566",
          "name": "organonitrogen compound biosynthetic process"
        },
        {
          "id": "GO:1904938",
          "name": "planar cell polarity pathway involved in axon guidance"
        },
        {
          "id": "GO:1905661",
          "name": "regulation of telomerase RNA reverse transcriptase activity"
        },
        {
          "id": "GO:1905662",
          "name": "negative regulation of telomerase RNA reverse transcriptase activity"
        },
        {
          "id": "GO:1905663",
          "name": "positive regulation of telomerase RNA reverse transcriptase activity"
        },
        {
          "id": "GO:2000162",
          "name": "negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis"
        },
        {
          "id": "GO:2000286",
          "name": "receptor internalization involved in canonical Wnt signaling pathway"
        }
      ]
    },
    "merged_terms": {},
    "meta_statements": {
      "biological_process": [
        {
          "id": "GO:0000196",
          "name": "cell integrity MAPK cascade",
          "changes": {
            "name": {
              "current": "cell integrity MAPK cascade",
              "previous": "cell wall integrity MAPK cascade"
            },
            "definition": {
              "current": "\"A MAPK cascade that specifically ensures the maintenance and regulation of cellular structure in response to external signals, including plasma membrane stretching or cell wall alteration, to coordinate cellular responses such as growth, differentiation, and stress adaptation, thereby preserving cell integrity. Contains the  SLT2 (S.cerevisiae)/Pmk1 (S.pombe) MAP kinase or orthologs.\" [GOC:vw]",
              "previous": "\"A MAPK cascade containing at least the SLT2 (S.cerevisiae)/Pmk1 (S.pombe) MAP kinase. It starts with the activation of an upstream MAP4K, and continues with the consecutive activation of a MAP3K and a MAP2K. The upstream MAP4K is activated following the detection of stretching of the plasma membrane or alterations of its connections to the cell wall by membrane sensors.\" [PMID:15944456, PMID:17604854, PMID:22174182, PMID:26945038, PMID:9561267]"
            },
            "synonyms": {
              "current": [
                "\"cell integrity MAPK pathway\" EXACT [GOC:vw, PMID:23934882]",
                "\"cell wall integrity MAPK cascade\" NARROW []",
                "\"CWI pathway\" RELATED []",
                "\"Mpk1 cascade\" NARROW [PMID:10523653]",
                "\"Pmk1 MAPK cell integrity signaling\" NARROW [PMID:20032302]",
                "\"Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [PMID:23934882]",
                "\"PMK1-MAPK signal transduction pathway\" NARROW [PMID:23454094]",
                "\"Slt2 cascade\" NARROW [PMID:10523653]"
              ],
              "previous": [
                "\"cell integrity MAPK pathway\" EXACT [GOC:vw, PMID:23934882]",
                "\"cell wall biogenesis, MAPKKK cascade\" EXACT []",
                "\"CWI pathway\" RELATED []",
                "\"MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:vw]",
                "\"MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:signaling]",
                "\"Mpk1 cascade\" NARROW [PMID:10523653]",
                "\"Pmk1 MAPK cell integrity signaling\" NARROW [PMID:20032302]",
                "\"Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [PMID:23934882]",
                "\"PMK1-MAPK signal transduction pathway\" NARROW [PMID:23454094]",
                "\"Slt2 cascade\" NARROW [PMID:10523653]"
              ]
            }
          }
        },
        {
          "id": "GO:0000366",
          "name": "mRNA alternative trans-splicing",
          "changes": {
            "name": {
              "current": "mRNA alternative trans-splicing",
              "previous": "intergenic mRNA trans splicing"
            },
            "synonyms": {
              "current": [
                "\"intergenic mRNA trans splicing\" EXACT []",
                "\"intergenic nuclear mRNA trans splicing\" EXACT [GOC:vw]"
              ],
              "previous": [
                "\"intergenic nuclear mRNA trans splicing\" EXACT [GOC:vw]"
              ]
            }
          }
        },
        {
          "id": "GO:0001932",
          "name": "regulation of protein phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0001933",
          "name": "negative regulation of protein phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0001934",
          "name": "positive regulation of protein phosphorylation",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC."
            },
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0006540",
          "name": "gamma-aminobutyrate shunt",
          "changes": {
            "name": {
              "current": "gamma-aminobutyrate shunt",
              "previous": "glutamate decarboxylation to succinate"
            },
            "synonyms": {
              "current": [
                "\"4-aminobutyrate shunt\" EXACT []",
                "\"degradation of glutamate to succinate through GABA\" EXACT [MetaCyc:GLUDEG-I-PWY]",
                "\"GABA shunt\" EXACT []",
                "\"gamma aminobutyrate shunt\" EXACT []",
                "\"glutamate decarboxylation to succinate\" EXACT []",
                "\"glutamate degradation via 4-aminobutyrate\" EXACT [MetaCyc:GLUDEG-I-PWY]",
                "\"glutamate degradation via GABA\" EXACT [MetaCyc:GLUDEG-I-PWY]"
              ],
              "previous": [
                "\"4-aminobutyrate shunt\" EXACT []",
                "\"degradation of glutamate to succinate through GABA\" EXACT [MetaCyc:GLUDEG-I-PWY]",
                "\"GABA shunt\" EXACT []",
                "\"gamma-aminobutyrate shunt\" EXACT []",
                "\"glutamate degradation via 4-aminobutyrate\" EXACT [MetaCyc:GLUDEG-I-PWY]",
                "\"glutamate degradation via GABA\" EXACT [MetaCyc:GLUDEG-I-PWY]"
              ]
            }
          }
        },
        {
          "id": "GO:0006635",
          "name": "fatty acid beta-oxidation",
          "changes": {
            "definition": {
              "current": "\"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:mah, ISBN:0198506732]",
              "previous": "\"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]"
            }
          }
        },
        {
          "id": "GO:0006950",
          "name": "response to stress",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC."
            }
          }
        },
        {
          "id": "GO:0007175",
          "name": "negative regulation of epidermal growth factor-activated receptor activity",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": [
                "gocheck_do_not_annotate"
              ]
            }
          }
        },
        {
          "id": "GO:0007200",
          "name": "phospholipase C-activating G protein-coupled receptor signaling pathway",
          "changes": {
            "definition": {
              "current": "\"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.\" [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]",
              "previous": "\"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).\" [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]"
            },
            "comment": {
              "current": "N/A",
              "previous": "This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity."
            },
            "synonyms": {
              "current": [
                "\"activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger\" RELATED [GOC:signaling]",
                "\"G protein signaling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"G protein signalling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"G-protein coupled receptor signaling pathway coupled to IP3 second messenger\" EXACT [GOC:signaling]",
                "\"G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT [GOC:dph, GOC:tb]",
                "\"G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"phospholipase C-activating G-protein coupled receptor signaling pathway\" EXACT []",
                "\"PLC-activating GPCR signaling pathway\" EXACT [GOC:signaling]",
                "\"protein kinase C-activating G protein-coupled receptor signaling pathway\" EXACT []"
              ],
              "previous": [
                "\"activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger\" RELATED [GOC:signaling]",
                "\"G protein signaling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"G protein signalling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"G-protein coupled receptor signaling pathway coupled to IP3 second messenger\" EXACT [GOC:signaling]",
                "\"G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT [GOC:dph, GOC:tb]",
                "\"G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)\" EXACT []",
                "\"phospholipase C-activating dopamine receptor signaling pathway\" NARROW [GOC:dph, GOC:tb]",
                "\"phospholipase C-activating G-protein coupled receptor signaling pathway\" EXACT []",
                "\"PLC-activating GPCR signaling pathway\" EXACT [GOC:signaling]"
              ]
            }
          }
        },
        {
          "id": "GO:0010799",
          "name": "regulation of peptidyl-threonine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0010800",
          "name": "positive regulation of peptidyl-threonine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0010801",
          "name": "negative regulation of peptidyl-threonine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0010999",
          "name": "regulation of eIF2 alpha phosphorylation by heme",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0018911",
          "name": "1,2,4-trichlorobenzene catabolic process",
          "changes": {
            "name": {
              "current": "1,2,4-trichlorobenzene catabolic process",
              "previous": "1,2,4-trichlorobenzene metabolic process"
            },
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides.\" [PMID:1987135]",
              "previous": "\"The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides.\" [http://www.speclab.com/compound/c120821.htm]"
            },
            "synonyms": {
              "current": [
                "\"1,2,4-trichlorobenzene metabolic process\" BROAD []",
                "\"1,2,4-trichlorobenzene metabolism\" BROAD []"
              ],
              "previous": [
                "\"1,2,4-trichlorobenzene metabolism\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0018914",
          "name": "chlorobenzene catabolic process",
          "changes": {
            "name": {
              "current": "chlorobenzene catabolic process",
              "previous": "chlorobenzene metabolic process"
            },
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone.\" [PMID:10808489, PMID:8626733]",
              "previous": "\"The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone.\" [http://www.shsu.edu/]"
            },
            "synonyms": {
              "current": [
                "\"chlorobenzene metabolic process\" BROAD []",
                "\"chlorobenzene metabolism\" BROAD []"
              ],
              "previous": [
                "\"chlorobenzene metabolism\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0018915",
          "name": "ethylbenzene catabolic process",
          "changes": {
            "name": {
              "current": "ethylbenzene catabolic process",
              "previous": "ethylbenzene metabolic process"
            },
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels.\" [PMID:8795196]",
              "previous": "\"The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels.\" [http://www.speclab.com/compound/c100414.htm]"
            },
            "synonyms": {
              "current": [
                "\"ethylbenzene metabolic process\" BROAD []",
                "\"ethylbenzene metabolism\" BROAD []"
              ],
              "previous": [
                "\"ethylbenzene metabolism\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0019256",
          "name": "acrylonitrile catabolic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers.\" [GOC:ai, PMID:1390687, PMID:3830164]",
              "previous": "\"The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers.\" [GOC:ai]"
            }
          }
        },
        {
          "id": "GO:0019261",
          "name": "1,4-dichlorobenzene catabolic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.\" [GOC:ai, PMID:9148781]",
              "previous": "\"The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.\" [GOC:ai]"
            }
          }
        },
        {
          "id": "GO:0019337",
          "name": "tetrachloroethylene catabolic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.\" [GOC:ai, PMID:7988892, PMID:8663199]",
              "previous": "\"The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.\" [GOC:ai]"
            }
          }
        },
        {
          "id": "GO:0019395",
          "name": "fatty acid oxidation",
          "changes": {
            "definition": {
              "current": "\"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.\" [ISBN:0198506732]",
              "previous": "\"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.\" [ISBN:0198506732, MetaCyc:FAO-PWY]"
            }
          }
        },
        {
          "id": "GO:0019418",
          "name": "sulfide oxidation",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.\" [MetaCyc:Sulfide-Oxidation]",
              "previous": "\"The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.\" [MetaCyc:P222-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]"
            }
          }
        },
        {
          "id": "GO:0019590",
          "name": "L-arabitol catabolic process to xylulose 5-phosphate",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate.\" [GOC:curators]",
              "previous": "\"The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate.\" [MetaCyc:LARABITOLUTIL-PWY]"
            }
          }
        },
        {
          "id": "GO:0019640",
          "name": "D-glucuronate catabolic process to D-xylulose 5-phosphate",
          "changes": {
            "name": {
              "current": "D-glucuronate catabolic process to D-xylulose 5-phosphate",
              "previous": "glucuronate catabolic process to xylulose 5-phosphate"
            },
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the breakdown of D-glucuronate into D-xylulose 5-phosphate.\" [GOC:go_curators, PMID:27189775]",
              "previous": "\"The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.\" [GOC:go_curators]"
            },
            "synonyms": {
              "current": [
                "\"glucuronate breakdown to xylulose 5-phosphate\" EXACT []",
                "\"glucuronate catabolic process to xylulose 5-phosphate\" EXACT []",
                "\"glucuronate degradation to xylulose 5-phosphate\" EXACT []"
              ],
              "previous": [
                "\"glucuronate breakdown to xylulose 5-phosphate\" EXACT []",
                "\"glucuronate degradation to xylulose 5-phosphate\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0031566",
          "name": "actomyosin contractile ring maturation",
          "changes": {
            "synonyms": {
              "current": [
                "\"actomyosin contractile ring maintenance\" RELATED []",
                "\"cytokinesis, contractile ring maintenance\" RELATED []"
              ],
              "previous": [
                "\"actomyosin contractile ring maintenance\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0031952",
          "name": "regulation of protein autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0031953",
          "name": "negative regulation of protein autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0031954",
          "name": "positive regulation of protein autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033135",
          "name": "regulation of peptidyl-serine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033137",
          "name": "negative regulation of peptidyl-serine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033138",
          "name": "positive regulation of peptidyl-serine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033140",
          "name": "negative regulation of peptidyl-serine phosphorylation of STAT protein",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033141",
          "name": "positive regulation of peptidyl-serine phosphorylation of STAT protein",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033468",
          "name": "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate.\" [GOC:mah, MetaCyc:PWY-1269]",
              "previous": "\"The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate.\" [GOC:mah, MetaCyc:PWY-5111]"
            }
          }
        },
        {
          "id": "GO:0033539",
          "name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase",
          "changes": {
            "definition": {
              "current": "\"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:mah, MetaCyc:FAO-PWY]",
              "previous": "\"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]"
            }
          }
        },
        {
          "id": "GO:0033554",
          "name": "cellular response to stress",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC."
            },
            "subsets": {
              "current": "N/A",
              "previous": [
                "gocheck_do_not_annotate"
              ]
            }
          }
        },
        {
          "id": "GO:0034077",
          "name": "butanediol metabolic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123, MetaCyc:BUTANEDIOL]",
              "previous": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]"
            }
          }
        },
        {
          "id": "GO:0034079",
          "name": "butanediol biosynthetic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]",
              "previous": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]"
            }
          }
        },
        {
          "id": "GO:0035499",
          "name": "carnosine biosynthetic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).\" [PMID:20097752]",
              "previous": "\"The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).\" [EC:6.3.2.11, PMID:20097752]"
            }
          }
        },
        {
          "id": "GO:0039540",
          "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"inhibition by virus of host DDX58 activity\" RELATED [GOC:sp]",
                "\"inhibition by virus of host RIG-I\" RELATED []",
                "\"inhibition by virus of host RIG-I signaling\" RELATED []",
                "\"inhibition of host DDX58/RIG-I by virus\" EXACT []",
                "\"suppression by virus of host DDX58 signaling pathway\" RELATED []",
                "\"suppression by virus of host RIG-I activity\" RELATED []",
                "\"suppression by virus of host RIG-I signaling pathway\" RELATED []",
                "\"suppression by virus of host RIG-I signalling pathway\" EXACT []",
                "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity\" NARROW []",
                "\"symbiont-mediated suppression of host RIG-I signaling pathway\" RELATED []"
              ],
              "previous": [
                "\"inhibition by virus of host DDX58 activity\" RELATED [GOC:sp]",
                "\"inhibition by virus of host RIG-I\" RELATED []",
                "\"inhibition by virus of host RIG-I signaling\" RELATED []",
                "\"inhibition of host DDX58/RIG-I by virus\" EXACT []",
                "\"suppression by virus of host DDX58 signaling pathway\" RELATED []",
                "\"suppression by virus of host RIG-I activity\" RELATED []",
                "\"suppression by virus of host RIG-I signaling pathway\" RELATED []",
                "\"suppression by virus of host RIG-I signalling pathway\" EXACT []",
                "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity\" NARROW []"
              ]
            }
          }
        },
        {
          "id": "GO:0039723",
          "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"inhibition of host TBK1 by virus\" RELATED []",
                "\"suppression by virus of host TBK1 activity\" RELATED []",
                "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity\" NARROW []",
                "\"symbiont-mediated suppression of host TKB signaling\" RELATED []"
              ],
              "previous": [
                "\"inhibition of host TBK1 by virus\" RELATED []",
                "\"suppression by virus of host TBK1 activity\" RELATED []",
                "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity\" NARROW []"
              ]
            }
          }
        },
        {
          "id": "GO:0042509",
          "name": "regulation of tyrosine phosphorylation of STAT protein",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0042531",
          "name": "positive regulation of tyrosine phosphorylation of STAT protein",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0042532",
          "name": "negative regulation of tyrosine phosphorylation of STAT protein",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0043538",
          "name": "regulation of actin phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0044083",
          "name": "symbiont-mediated perturbation of host Rho small GTPase signal transduction",
          "changes": {
            "name": {
              "current": "symbiont-mediated perturbation of host Rho small GTPase signal transduction",
              "previous": "symbiont-mediated perturbation of host Rho signal transduction"
            }
          }
        },
        {
          "id": "GO:0044085",
          "name": "cellular component biogenesis",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "goslim_pir"
              ],
              "previous": [
                "goslim_pir"
              ]
            }
          }
        },
        {
          "id": "GO:0045741",
          "name": "positive regulation of epidermal growth factor-activated receptor activity",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": [
                "gocheck_do_not_annotate"
              ]
            }
          }
        },
        {
          "id": "GO:0050730",
          "name": "regulation of peptidyl-tyrosine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0050732",
          "name": "negative regulation of peptidyl-tyrosine phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0060734",
          "name": "regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0060735",
          "name": "regulation of eIF2 alpha phosphorylation by dsRNA",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0061680",
          "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde",
          "changes": {
            "definition": {
              "current": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.\" [GOC:dph, MetaCyc:NPGLUCAT-PWY, PMID:12921536]",
              "previous": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.\" [GOC:dph, MetaCyc:ENTNER-DOUDOROFF-PWY-II, PMID:12921536]"
            }
          }
        },
        {
          "id": "GO:0141127",
          "name": "symbiont-mediated perturbation of host Rab small GTPase signal transduction",
          "changes": {
            "name": {
              "current": "symbiont-mediated perturbation of host Rab small GTPase signal transduction",
              "previous": "symbiont-mediated perturbation of host Rab signal transduction"
            }
          }
        },
        {
          "id": "GO:1900084",
          "name": "regulation of peptidyl-tyrosine autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1900085",
          "name": "negative regulation of peptidyl-tyrosine autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1900086",
          "name": "positive regulation of peptidyl-tyrosine autophosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1901792",
          "name": "3-(2,3-dihydroxyphenyl)propanoate biosynthetic process",
          "changes": {
            "definition": {
              "current": "\"The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN]",
              "previous": "\"The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]"
            }
          }
        },
        {
          "id": "GO:1902406",
          "name": "mitotic actomyosin contractile ring maturation",
          "changes": {
            "synonyms": {
              "current": [
                "\"mitotic cytokinesis contractile ring maintenance\" RELATED []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1903137",
          "name": "regulation of cell integrity MAPK cascade",
          "changes": {
            "name": {
              "current": "regulation of cell integrity MAPK cascade",
              "previous": "regulation of cell wall integrity MAPK cascade"
            },
            "definition": {
              "current": "\"Any process that modulates the frequency, rate or extent of a cell integrity MAPK cascade.\" [GOC:vw]",
              "previous": "\"Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.\" [GO_REF:0000058, GOC:TermGenie]"
            },
            "synonyms": {
              "current": [
                "\"regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"regulation of cell wall integrity MAPK cascade\" NARROW []",
                "\"regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"regulation of Slt2 cascade\" NARROW [GOC:TermGenie]"
              ],
              "previous": [
                "\"regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"regulation of Slt2 cascade\" NARROW [GOC:TermGenie]"
              ]
            }
          }
        },
        {
          "id": "GO:1903138",
          "name": "negative regulation of cell integrity MAPK cascade",
          "changes": {
            "name": {
              "current": "negative regulation of cell integrity MAPK cascade",
              "previous": "negative regulation of cell wall integrity MAPK cascade"
            },
            "definition": {
              "current": "\"Any process that stops, prevents or reduces the frequency, rate or extent of a cell integrity MAPK cascade.\" [GOC:vw]",
              "previous": "\"Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.\" [GO_REF:0000058, GOC:TermGenie, PMID:23934882]"
            },
            "synonyms": {
              "current": [
                "\"inhibition of cell wall biogenesis, MAPKKK cascade\" NARROW [GOC:TermGenie]",
                "\"inhibition of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"negative regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"negative regulation of cell wall integrity MAPK cascade\" NARROW []",
                "\"negative regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"negative regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"negative regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"negative regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]"
              ],
              "previous": [
                "\"down regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"down regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"down regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"down regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"down regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"down regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"down regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"down regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"down regulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"down-regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"down-regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"down-regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"down-regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"down-regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"down-regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"down-regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"down-regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"down-regulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"downregulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"downregulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"downregulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"downregulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"downregulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"downregulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"downregulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"downregulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"downregulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"inhibition of cell integrity MAPK pathway\" NARROW [GOC:TermGenie]",
                "\"inhibition of cell wall biogenesis, MAPKKK cascade\" NARROW [GOC:TermGenie]",
                "\"inhibition of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"inhibition of MAPK cascade involved in cell wall organization or biogenesis\" NARROW [GOC:TermGenie]",
                "\"inhibition of MAPKKK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"inhibition of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"inhibition of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"inhibition of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"inhibition of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"negative regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"negative regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"negative regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"negative regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"negative regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"negative regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"negative regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"negative regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"negative regulation of Slt2 cascade\" NARROW [GOC:TermGenie]"
              ]
            }
          }
        },
        {
          "id": "GO:1903139",
          "name": "positive regulation of cell integrity MAPK cascade",
          "changes": {
            "name": {
              "current": "positive regulation of cell integrity MAPK cascade",
              "previous": "positive regulation of cell wall integrity MAPK cascade"
            },
            "definition": {
              "current": "\"Any process that activates or increases the frequency, rate or extent of a cell integrity MAPK cascade.\" [GOC:vw]",
              "previous": "\"Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis.\" [GO_REF:0000058, GOC:TermGenie]"
            },
            "synonyms": {
              "current": [
                "\"activation of cell integrity MAPK pathway\" NARROW [GOC:TermGenie]",
                "\"activation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"activation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"activation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"activation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"positive regulation of cell wal integrity MAPK pathway\" EXACT []",
                "\"positive regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"positive regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"positive regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"positive regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"positive regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Slt2 cascade\" NARROW [GOC:TermGenie]"
              ],
              "previous": [
                "\"activation of cell integrity MAPK pathway\" NARROW [GOC:TermGenie]",
                "\"activation of cell wall biogenesis, MAPKKK cascade\" NARROW [GOC:TermGenie]",
                "\"activation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"activation of MAPK cascade involved in cell wall organization or biogenesis\" NARROW [GOC:TermGenie]",
                "\"activation of MAPKKK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"activation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"activation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"activation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"activation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"positive regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"positive regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"positive regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"positive regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT []",
                "\"positive regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"positive regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"positive regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"positive regulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"up regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"up regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"up regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"up regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"up regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"up regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"up regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"up regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"up regulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"up-regulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"up-regulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"up-regulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"up-regulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"up-regulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"up-regulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"up-regulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"up-regulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"up-regulation of Slt2 cascade\" NARROW [GOC:TermGenie]",
                "\"upregulation of cell integrity MAPK pathway\" EXACT [GOC:TermGenie]",
                "\"upregulation of cell wall biogenesis, MAPKKK cascade\" EXACT [GOC:TermGenie]",
                "\"upregulation of MAPK cascade involved in cell wall biogenesis\" NARROW [GOC:TermGenie]",
                "\"upregulation of MAPK cascade involved in cell wall organization or biogenesis\" EXACT [GOC:TermGenie]",
                "\"upregulation of MAPKKK cascade involved in cell wall biogenesis\" EXACT [GOC:TermGenie]",
                "\"upregulation of Mpk1 cascade\" NARROW [GOC:TermGenie]",
                "\"upregulation of Pmk1 MAPK cell integrity signaling\" NARROW [GOC:TermGenie]",
                "\"upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway\" NARROW [GOC:TermGenie]",
                "\"upregulation of PMK1-MAPK signal transduction pathway\" NARROW [GOC:TermGenie]",
                "\"upregulation of Slt2 cascade\" NARROW [GOC:TermGenie]"
              ]
            }
          }
        },
        {
          "id": "GO:1903719",
          "name": "regulation of I-kappaB phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1903720",
          "name": "negative regulation of I-kappaB phosphorylation",
          "changes": {
            "synonyms": {
              "current": [
                "\"inhibition of I-kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of IkappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of IKB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of inhibitor of kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of inhibitor of NF-kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"negative regulation of IkappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of IKB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of inhibitor of kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of inhibitor of NF-kappaB phosphorylation\" EXACT [GOC:TermGenie]"
              ],
              "previous": [
                "\"down regulation of I-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down regulation of IkappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down regulation of IKB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down regulation of inhibitor of kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down regulation of inhibitor of NF-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down-regulation of I-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down-regulation of IkappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down-regulation of IKB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down-regulation of inhibitor of kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"down-regulation of inhibitor of NF-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"downregulation of I-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"downregulation of IkappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"downregulation of IKB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"downregulation of inhibitor of kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"downregulation of inhibitor of NF-kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"inhibition of I-kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of IkappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of IKB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of inhibitor of kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"inhibition of inhibitor of NF-kappaB phosphorylation\" NARROW [GOC:TermGenie]",
                "\"negative regulation of IkappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of IKB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of inhibitor of kappaB phosphorylation\" EXACT [GOC:TermGenie]",
                "\"negative regulation of inhibitor of NF-kappaB phosphorylation\" EXACT [GOC:TermGenie]"
              ]
            },
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1903721",
          "name": "positive regulation of I-kappaB phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1903912",
          "name": "negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1904323",
          "name": "regulation of inhibitory G protein-coupled receptor phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1904324",
          "name": "negative regulation of inhibitory G protein-coupled receptor phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1904325",
          "name": "positive regulation of inhibitory G protein-coupled receptor phosphorylation",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "gocheck_obsoletion_candidate"
              ],
              "previous": "N/A"
            }
          }
        }
      ],
      "molecular_function": [
        {
          "id": "GO:0000225",
          "name": "N-acetylglucosaminylphosphatidylinositol deacetylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:3.1.1.69."
            }
          }
        },
        {
          "id": "GO:0000247",
          "name": "C-8 sterol isomerase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.\" [MetaCyc:RXN3O-203, PMID:8988026]"
            }
          }
        },
        {
          "id": "GO:0000824",
          "name": "inositol-1,4,5,6-tetrakisphosphate 3-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,4,5,6-tetrakisphosphate 3-kinase activity",
              "previous": "inositol tetrakisphosphate 3-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-tetrakisphosphate 3-kinase activity\" BROAD []",
                "\"inositol 1,4,5,6-tetrakisphosphate 3-kinase activity\" EXACT []",
                "\"inositol polyphosphate multikinase activity\" BROAD []",
                "\"inositol tetrakisphosphate 3-kinase activity\" BROAD []",
                "\"IpmK\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-tetrakisphosphate 3-kinase activity\" EXACT []",
                "\"EC:2.7.1.151\" BROAD []",
                "\"inositol 1,4,5,6-tetrakisphosphate 3-kinase activity\" EXACT []",
                "\"inositol polyphosphate multikinase activity\" BROAD []",
                "\"IpmK\" BROAD []"
              ]
            }
          }
        },
        {
          "id": "GO:0000825",
          "name": "inositol-1,3,4,5-tetrakisphosphate 6-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,3,4,5-tetrakisphosphate 6-kinase activity",
              "previous": "inositol tetrakisphosphate 6-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-tetrakisphosphate 6-kinase activity\" BROAD []",
                "\"inositol 1,3,4,5-tetrakisphosphate 6-kinase activity\" EXACT []",
                "\"inositol tetrakisphosphate 6-kinase activity\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-tetrakisphosphate 6-kinase activity\" EXACT []",
                "\"inositol 1,3,4,5-tetrakisphosphate 6-kinase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0000829",
          "name": "diphosphoinositol pentakisphosphate kinase activity",
          "changes": {
            "name": {
              "current": "diphosphoinositol pentakisphosphate kinase activity",
              "previous": "inositol heptakisphosphate kinase activity"
            },
            "synonyms": {
              "current": [
                "\"inositol heptakisphosphate kinase activity\" EXACT []",
                "\"PP-IP5 kinase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0000833",
          "name": "5-diphosphoinositol pentakisphosphate 4-kinase activity",
          "changes": {
            "name": {
              "current": "5-diphosphoinositol pentakisphosphate 4-kinase activity",
              "previous": "inositol heptakisphosphate 4-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"diphosphoinositol-pentakisphosphate 4-kinase activity\" BROAD []",
                "\"inositol heptakisphosphate 4-kinase activity\" BROAD []",
                "\"IP7 4-kinase activity\" EXACT []"
              ],
              "previous": [
                "\"diphosphoinositol-pentakisphosphate 4-kinase activity\" EXACT []",
                "\"IP7 4-kinase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0000834",
          "name": "5-diphosphoinositol pentakisphosphate 6-kinase activity",
          "changes": {
            "name": {
              "current": "5-diphosphoinositol pentakisphosphate 6-kinase activity",
              "previous": "inositol heptakisphosphate 6-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"inositol heptakisphosphate 6-kinase activity\" BROAD []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0001512",
          "name": "dihydronicotinamide riboside quinone reductase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.10.99.2."
            }
          }
        },
        {
          "id": "GO:0002952",
          "name": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione.\" [EC:5.3.1.32]"
            }
          }
        },
        {
          "id": "GO:0003720",
          "name": "telomerase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"telomerase RNA reverse transcriptase activity\" EXACT []",
                "\"telomerase, catalyst\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0003834",
          "name": "beta-carotene 15,15'-dioxygenase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.13.11.n2, EC:1.13.11.21 and then EC 1.14.99.36."
            }
          }
        },
        {
          "id": "GO:0003849",
          "name": "3-deoxy-7-phosphoheptulonate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.2.15."
            }
          }
        },
        {
          "id": "GO:0003851",
          "name": "N-acylsphingosine galactosyltransferase activity",
          "changes": {
            "name": {
              "current": "N-acylsphingosine galactosyltransferase activity",
              "previous": "N-acylsphingosine galactosyltransferase"
            }
          }
        },
        {
          "id": "GO:0003852",
          "name": "2-isopropylmalate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.12."
            }
          }
        },
        {
          "id": "GO:0003853",
          "name": "short-chain 2-methyl fatty acyl-CoA dehydrogenase activity",
          "changes": {
            "name": {
              "current": "short-chain 2-methyl fatty acyl-CoA dehydrogenase activity",
              "previous": "2-methylbutanoyl-CoA dehydrogenase activity"
            },
            "synonyms": {
              "current": [
                "\"2-methyl branched chain acyl-CoA dehydrogenase activity\" NARROW [EC:1.3.8.5]",
                "\"2-methyl-branched-chain-enoyl-CoA reductase activity\" RELATED []",
                "\"2-methylacyl-CoA dehydrogenase activity\" NARROW []",
                "\"2-methylbutanoyl-CoA dehydrogenase activity\" NARROW []",
                "\"2-methylpropanoyl-CoA dehydrogenase activity\" NARROW []",
                "\"branched-chain acyl-CoA dehydrogenase activity\" NARROW [EC:1.3.8.5]",
                "\"isobutyryl-CoA:FAD oxidoreductase activity\" NARROW []"
              ],
              "previous": [
                "\"2-methyl branched chain acyl-CoA dehydrogenase activity\" RELATED [EC:1.3.8.5]",
                "\"2-methyl-branched-chain-enoyl-CoA reductase activity\" RELATED []",
                "\"2-methylacyl-CoA dehydrogenase activity\" BROAD []",
                "\"branched-chain acyl-CoA dehydrogenase activity\" RELATED [EC:1.3.8.5]"
              ]
            }
          }
        },
        {
          "id": "GO:0003875",
          "name": "ADP-ribosylarginine hydrolase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reactions",
              "previous": "\"Catalysis of the reaction"
            }
          }
        },
        {
          "id": "GO:0003878",
          "name": "ATP citrate synthase activity",
          "changes": {
            "comment": {
              "current": "Note that this term has a MetaCyc pathway reference as the pathway only has a single step.",
              "previous": "Note that this function was formerly EC:4.1.3.8. Note that this term has a MetaCyc pathway reference as the pathway only has a single step."
            }
          }
        },
        {
          "id": "GO:0003886",
          "name": "DNA (cytosine-5-)-methyltransferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37)."
            }
          }
        },
        {
          "id": "GO:0003920",
          "name": "GMP reductase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.6.6.8."
            }
          }
        },
        {
          "id": "GO:0003941",
          "name": "L-serine ammonia-lyase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.3.1.13."
            }
          }
        },
        {
          "id": "GO:0003950",
          "name": "NAD+-protein poly-ADP-ribosyltransferase activity",
          "changes": {
            "name": {
              "current": "NAD+-protein poly-ADP-ribosyltransferase activity",
              "previous": "NAD+ ADP-ribosyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"ADP-ribosyltransferase (polymerizing) activity\" RELATED [EC:2.4.2.30]",
                "\"NAD ADP-ribosyltransferase activity\" EXACT []",
                "\"NAD+ ADP-ribosyltransferase activity\" BROAD []",
                "\"NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(adenosine diphosphate ribose) polymerase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose) synthase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose) synthetase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose)polymerase activity\" RELATED [EC:2.4.2.30]"
              ],
              "previous": [
                "\"ADP-ribosyltransferase (polymerizing) activity\" RELATED [EC:2.4.2.30]",
                "\"NAD ADP-ribosyltransferase activity\" EXACT []",
                "\"NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(adenosine diphosphate ribose) polymerase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose) synthase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose) synthetase activity\" RELATED [EC:2.4.2.30]",
                "\"poly(ADP-ribose)polymerase activity\" RELATED [EC:2.4.2.30]"
              ]
            }
          }
        },
        {
          "id": "GO:0003961",
          "name": "O-acetylhomoserine aminocarboxypropyltransferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.2.99.10."
            }
          }
        },
        {
          "id": "GO:0003984",
          "name": "acetolactate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.18."
            }
          }
        },
        {
          "id": "GO:0004051",
          "name": "arachidonate 5-lipoxygenase activity",
          "changes": {
            "comment": {
              "current": "Note that this is a multi-step reaction.",
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0004077",
          "name": "biotin--[biotin carboxyl-carrier protein] ligase activity",
          "changes": {
            "name": {
              "current": "biotin--[biotin carboxyl-carrier protein] ligase activity",
              "previous": "biotin-[acetyl-CoA-carboxylase] ligase activity"
            },
            "synonyms": {
              "current": [
                "\"acetyl CoA holocarboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"acetyl coenzyme A holocarboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"acetyl-CoA carboxylase biotin holoenzyme synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin holoenzyme synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin--[acetyl-CoA carboxylase] synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin--protein ligase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin-acetyl coenzyme A carboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin-acetyl-CoA carboxylase synthetase\" BROAD [EC:6.3.4.15]",
                "\"biotin-acetyl-CoA-carboxylase ligase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin-protein ligase activity\" EXACT []",
                "\"biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)\" RELATED [EC:6.3.4.15]",
                "\"biotin:apocarboxylase ligase activity\" RELATED [EC:6.3.4.15]",
                "\"HCS\" RELATED [EC:6.3.4.15]"
              ],
              "previous": [
                "\"acetyl CoA holocarboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"acetyl coenzyme A holocarboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"acetyl-CoA carboxylase biotin holoenzyme synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin holoenzyme synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin--[acetyl-CoA carboxylase] synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin--protein ligase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin-acetyl coenzyme A carboxylase synthetase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin-acetyl-CoA carboxylase synthetase\" BROAD [EC:6.3.4.15]",
                "\"biotin-acetyl-CoA-carboxylase ligase activity\" RELATED [EC:6.3.4.15]",
                "\"biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)\" RELATED [EC:6.3.4.15]",
                "\"biotin:apocarboxylase ligase activity\" RELATED [EC:6.3.4.15]",
                "\"HCS\" RELATED [EC:6.3.4.15]"
              ]
            }
          }
        },
        {
          "id": "GO:0004108",
          "name": "citrate (Si)-synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.7."
            }
          }
        },
        {
          "id": "GO:0004124",
          "name": "cysteine synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly 4.2.99.8."
            }
          }
        },
        {
          "id": "GO:0004155",
          "name": "6,7-dihydropteridine reductase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.6.99.7."
            }
          }
        },
        {
          "id": "GO:0004311",
          "name": "farnesyltranstransferase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"geranylgeranyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.29]",
                "\"geranylgeranyl pyrophosphate synthetase activity\" EXACT [EC:2.5.1.29]",
                "\"geranylgeranyl-diphosphate synthase activity\" EXACT [EC:2.5.1.29]",
                "\"geranylgeranyl-PP synthetase activity\" EXACT [EC:2.5.1.29]",
                "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]"
              ],
              "previous": [
                "\"farnesyltransferase activity\" BROAD [EC:2.5.1.29]",
                "\"geranylgeranyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.29]",
                "\"geranylgeranyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.29]",
                "\"geranylgeranyl-diphosphate synthase activity\" RELATED [EC:2.5.1.29]",
                "\"geranylgeranyl-PP synthetase activity\" RELATED [EC:2.5.1.29]",
                "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]"
              ]
            }
          }
        },
        {
          "id": "GO:0004342",
          "name": "glucosamine-6-phosphate deaminase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:5.3.1.10."
            }
          }
        },
        {
          "id": "GO:0004362",
          "name": "glutathione-disulfide reductase (NADPH) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.6.4.2."
            }
          }
        },
        {
          "id": "GO:0004373",
          "name": "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity",
          "changes": {
            "name": {
              "current": "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity",
              "previous": "glycogen (starch) synthase activity"
            },
            "synonyms": {
              "current": [
                "\"glycogen (starch) synthetase activity\" EXACT []",
                "\"glyucogen (starch) synthase activity\" EXACT []",
                "\"UDP-glucose-glycogen glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"UDP-glycogen synthase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPG-glycogen synthetase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPG-glycogen transglucosylase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"uridine diphosphoglucose-glycogen glucosyltransferase activity\" RELATED [EC:2.4.1.11]"
              ],
              "previous": [
                "\"glycogen (starch) synthetase activity\" EXACT []",
                "\"UDP-glucose-glycogen glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"UDP-glycogen synthase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPG-glycogen synthetase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPG-glycogen transglucosylase activity\" RELATED [EC:2.4.1.11]",
                "\"UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity\" RELATED [EC:2.4.1.11]",
                "\"uridine diphosphoglucose-glycogen glucosyltransferase activity\" RELATED [EC:2.4.1.11]"
              ]
            }
          }
        },
        {
          "id": "GO:0004410",
          "name": "homocitrate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.21."
            }
          }
        },
        {
          "id": "GO:0004418",
          "name": "hydroxymethylbilane synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.3.1.8."
            }
          }
        },
        {
          "id": "GO:0004421",
          "name": "hydroxymethylglutaryl-CoA synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.5."
            }
          }
        },
        {
          "id": "GO:0004436",
          "name": "phosphatidylinositol diacylglycerol-lyase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:3.1.4.10."
            }
          }
        },
        {
          "id": "GO:0004474",
          "name": "malate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.2."
            }
          }
        },
        {
          "id": "GO:0004486",
          "name": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"5,10-methylene-THF dehydrogenase activity\" EXACT [GOC:vw]",
                "\"N5,N10-methylenetetrahydrofolate dehydrogenase activity\" RELATED []"
              ],
              "previous": [
                "\"5,10-methylene-THF dehydrogenase activity\" EXACT [GOC:vw]",
                "\"N5,N10-methylenetetrahydrofolate dehydrogenase activity\" RELATED [EC:1.5.1.5]"
              ]
            }
          }
        },
        {
          "id": "GO:0004533",
          "name": "exoribonuclease H activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.\" [EC:3.1.13.2]",
              "previous": "\"Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.\" [EC:3.1.13.2, ISBN:0198547684]"
            }
          }
        },
        {
          "id": "GO:0004558",
          "name": "alpha-1,4-glucosidase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"acid maltase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-D-glucosidase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-D-glucoside glucohydrolase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-glucopyranosidase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-glucoside hydrolase activity\" RELATED [EC:3.2.1.20]",
                "\"glucoinvertase activity\" RELATED [EC:3.2.1.20]",
                "\"glucosidoinvertase activity\" RELATED [EC:3.2.1.20]",
                "\"glucosidosucrase activity\" RELATED [EC:3.2.1.20]",
                "\"lysosomal alpha-glucosidase activity\" BROAD [EC:3.2.1.20]",
                "\"maltase-glucoamylase activity\" RELATED [EC:3.2.1.20]"
              ],
              "previous": [
                "\"acid maltase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-D-glucosidase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-D-glucoside glucohydrolase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-glucopyranosidase activity\" RELATED [EC:3.2.1.20]",
                "\"alpha-glucosidase II\" RELATED []",
                "\"alpha-glucoside hydrolase activity\" RELATED [EC:3.2.1.20]",
                "\"glucoinvertase activity\" RELATED [EC:3.2.1.20]",
                "\"glucosidoinvertase activity\" RELATED [EC:3.2.1.20]",
                "\"glucosidosucrase activity\" RELATED [EC:3.2.1.20]",
                "\"lysosomal alpha-glucosidase activity\" BROAD [EC:3.2.1.20]",
                "\"maltase-glucoamylase activity\" RELATED [EC:3.2.1.20]"
              ]
            }
          }
        },
        {
          "id": "GO:0004611",
          "name": "phosphoenolpyruvate carboxykinase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"PEP carboxykinase activity\" RELATED []",
                "\"PEPCK activity\" RELATED []",
                "\"phosphopyruvate carboxylase activity\" RELATED []"
              ],
              "previous": [
                "\"PEP carboxykinase activity\" RELATED [EC:4.1.1.32]",
                "\"PEPCK activity\" RELATED [EC:4.1.1.32]",
                "\"phosphopyruvate carboxylase activity\" RELATED [EC:4.1.1.32]"
              ]
            }
          }
        },
        {
          "id": "GO:0004683",
          "name": "calcium/calmodulin-dependent protein kinase activity",
          "changes": {
            "name": {
              "current": "calcium/calmodulin-dependent protein kinase activity",
              "previous": "calmodulin-dependent protein kinase activity"
            },
            "comment": {
              "current": "N/A",
              "previous": "These reactions require the presence of calcium-bound calmodulin."
            },
            "synonyms": {
              "current": [
                "\"ATP:caldesmon O-phosphotransferase activity\" NARROW [EC:2.7.11.17]",
                "\"ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity\" RELATED [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase 1 activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase activity\" RELATED [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase IV activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase kinase activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase kinase beta activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/CaM-dependent kinase activity\" EXACT []",
                "\"calcium- and calmodulin-dependent protein kinase activity\" EXACT []",
                "\"calcium/calmodulin-dependent protein kinase type II activity\" NARROW [EC:2.7.11.17]",
                "\"caldesmon kinase (phosphorylating) activity\" NARROW [EC:2.7.11.17]",
                "\"calmodulin regulated protein kinase activity\" EXACT []",
                "\"calmodulin-dependent kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"calmodulin-dependent protein kinase activity\" EXACT []",
                "\"calmodulin-dependent protein kinase I activity\" NARROW []",
                "\"CaM kinase activity\" RELATED [EC:2.7.11.17]",
                "\"CaM kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"CAM PKII\" RELATED [EC:2.7.11.17]",
                "\"CaM-regulated serine/threonine kinase activity\" RELATED [EC:2.7.11.17]",
                "\"CaMKI\" RELATED [EC:2.7.11.17]",
                "\"CaMKII\" RELATED [EC:2.7.11.17]",
                "\"CaMKIV\" RELATED [EC:2.7.11.17]",
                "\"CaMKKalpha\" RELATED [EC:2.7.11.17]",
                "\"CaMKKbeta\" RELATED [EC:2.7.11.17]",
                "\"microtubule-associated protein 2 kinase activity\" RELATED [EC:2.7.11.17]",
                "\"multifunctional calcium- and calmodulin-regulated protein kinase activity\" RELATED []",
                "\"multifunctional calcium/calmodulin regulated protein kinase activity\" RELATED []",
                "\"STK20\" RELATED [EC:2.7.11.17]"
              ],
              "previous": [
                "\"ATP:caldesmon O-phosphotransferase activity\" NARROW [EC:2.7.11.17]",
                "\"ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity\" RELATED [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase 1 activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase activity\" RELATED [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase IV activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase kinase activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/calmodulin-dependent protein kinase kinase beta activity\" NARROW [EC:2.7.11.17]",
                "\"Ca2+/CaM-dependent kinase activity\" EXACT []",
                "\"calcium- and calmodulin-dependent protein kinase activity\" EXACT []",
                "\"calcium/calmodulin-dependent protein kinase activity\" RELATED [EC:2.7.11.17]",
                "\"calcium/calmodulin-dependent protein kinase type II activity\" NARROW [EC:2.7.11.17]",
                "\"caldesmon kinase (phosphorylating) activity\" NARROW [EC:2.7.11.17]",
                "\"calmodulin regulated protein kinase activity\" EXACT []",
                "\"calmodulin-dependent kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"calmodulin-dependent protein kinase I activity\" NARROW []",
                "\"CaM kinase activity\" RELATED [EC:2.7.11.17]",
                "\"CaM kinase II activity\" NARROW [EC:2.7.11.17]",
                "\"CAM PKII\" RELATED [EC:2.7.11.17]",
                "\"CaM-regulated serine/threonine kinase activity\" RELATED [EC:2.7.11.17]",
                "\"CaMKI\" RELATED [EC:2.7.11.17]",
                "\"CaMKII\" RELATED [EC:2.7.11.17]",
                "\"CaMKIV\" RELATED [EC:2.7.11.17]",
                "\"CaMKKalpha\" RELATED [EC:2.7.11.17]",
                "\"CaMKKbeta\" RELATED [EC:2.7.11.17]",
                "\"microtubule-associated protein 2 kinase activity\" RELATED [EC:2.7.11.17]",
                "\"multifunctional calcium- and calmodulin-regulated protein kinase activity\" RELATED []",
                "\"multifunctional calcium/calmodulin regulated protein kinase activity\" RELATED []",
                "\"STK20\" RELATED [EC:2.7.11.17]"
              ]
            }
          }
        },
        {
          "id": "GO:0004698",
          "name": "calcium,diacylglycerol-dependent serine/threonine kinase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "This reaction requires diacylglycerol and calcium."
            }
          }
        },
        {
          "id": "GO:0004699",
          "name": "diacylglycerol-dependent, calcium-independent serine/threonine kinase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"atypical protein kinase C activity\" RELATED []",
                "\"calcium-independent PKC activity\" EXACT []",
                "\"novel protein kinase C activity\" EXACT [PMID:9601053]"
              ],
              "previous": [
                "\"calcium-independent PKC activity\" EXACT []",
                "\"novel protein kinase C activity\" EXACT [PMID:9601053]"
              ]
            }
          }
        },
        {
          "id": "GO:0004768",
          "name": "stearoyl-CoA 9-desaturase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.14.99.5."
            }
          }
        },
        {
          "id": "GO:0004771",
          "name": "sterol ester esterase activity",
          "changes": {
            "name": {
              "current": "sterol ester esterase activity",
              "previous": "sterol esterase activity"
            },
            "synonyms": {
              "current": [
                "\"acylcholesterol lipase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterol ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterol ester synthase activity\" NARROW [EC:3.1.1.13]",
                "\"cholesterol esterase activity\" NARROW [EC:3.1.1.13]",
                "\"cholesteryl ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesteryl ester synthase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesteryl esterase activity\" RELATED [EC:3.1.1.13]",
                "\"sterol ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"sterol esterase activity\" EXACT []",
                "\"steryl-ester acylhydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"triterpenol esterase activity\" RELATED [EC:3.1.1.13]"
              ],
              "previous": [
                "\"acylcholesterol lipase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterol ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesterol ester synthase activity\" NARROW [EC:3.1.1.13]",
                "\"cholesterol esterase activity\" NARROW [EC:3.1.1.13]",
                "\"cholesteryl ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesteryl ester synthase activity\" RELATED [EC:3.1.1.13]",
                "\"cholesteryl esterase activity\" RELATED [EC:3.1.1.13]",
                "\"sterol ester hydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"steryl-ester acylhydrolase activity\" RELATED [EC:3.1.1.13]",
                "\"triterpenol esterase activity\" RELATED [EC:3.1.1.13]"
              ]
            }
          }
        },
        {
          "id": "GO:0004806",
          "name": "triacylglycerol lipase activity",
          "changes": {
            "name": {
              "current": "triacylglycerol lipase activity",
              "previous": "triglyceride lipase activity"
            },
            "synonyms": {
              "current": [
                "\"amano AP\" RELATED [EC:3.1.1.3]",
                "\"amano B\" RELATED [EC:3.1.1.3]",
                "\"amano CE\" RELATED [EC:3.1.1.3]",
                "\"amano CES\" RELATED [EC:3.1.1.3]",
                "\"amano P\" RELATED [EC:3.1.1.3]",
                "\"amno N-AP\" RELATED [EC:3.1.1.3]",
                "\"butyrinase activity\" RELATED [EC:3.1.1.3]",
                "\"cacordase activity\" RELATED [EC:3.1.1.3]",
                "\"capalase L\" RELATED [EC:3.1.1.3]",
                "\"GA 56\" RELATED [EC:3.1.1.3]",
                "\"GEH\" RELATED [EC:3.1.1.3]",
                "\"glycerol ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"glycerol-ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"heparin releasable hepatic lipase\" NARROW [EC:3.1.1.3]",
                "\"hepatic lipase\" NARROW [EC:3.1.1.3]",
                "\"hepatic monoacylglycerol acyltransferase\" NARROW [EC:3.1.1.3]",
                "\"lipazin\" RELATED [EC:3.1.1.3]",
                "\"liver lipase\" NARROW [EC:3.1.1.3]",
                "\"meito MY 30\" RELATED [EC:3.1.1.3]",
                "\"meito sangyo OF lipase\" RELATED [EC:3.1.1.3]",
                "\"post-heparin plasma protamine-resistant lipase\" NARROW [EC:3.1.1.3]",
                "\"PPL\" RELATED [EC:3.1.1.3]",
                "\"salt-resistant post-heparin lipase\" NARROW [EC:3.1.1.3]",
                "\"steapsin\" RELATED [EC:3.1.1.3]",
                "\"TAG activity\" EXACT [PMID:16054079]",
                "\"takedo 1969-4-9\" RELATED [EC:3.1.1.3]",
                "\"triacetinase activity\" RELATED [EC:3.1.1.3]",
                "\"triacylglycerol acylhydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"triacylglycerol ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrin esterase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrinase activity\" RELATED [EC:3.1.1.3]",
                "\"triglyceridase activity\" RELATED [EC:3.1.1.3]",
                "\"triglyceride hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"triglyceride lipase activity\" EXACT []",
                "\"triolein hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"tween hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"tween-hydrolyzing esterase activity\" RELATED [EC:3.1.1.3]",
                "\"tweenase activity\" RELATED [EC:3.1.1.3]",
                "\"tweenesterase activity\" RELATED [EC:3.1.1.3]"
              ],
              "previous": [
                "\"amano AP\" RELATED [EC:3.1.1.3]",
                "\"amano B\" RELATED [EC:3.1.1.3]",
                "\"amano CE\" RELATED [EC:3.1.1.3]",
                "\"amano CES\" RELATED [EC:3.1.1.3]",
                "\"amano P\" RELATED [EC:3.1.1.3]",
                "\"amno N-AP\" RELATED [EC:3.1.1.3]",
                "\"butyrinase activity\" RELATED [EC:3.1.1.3]",
                "\"cacordase activity\" RELATED [EC:3.1.1.3]",
                "\"capalase L\" RELATED [EC:3.1.1.3]",
                "\"GA 56\" RELATED [EC:3.1.1.3]",
                "\"GEH\" RELATED [EC:3.1.1.3]",
                "\"glycerol ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"glycerol-ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"heparin releasable hepatic lipase\" NARROW [EC:3.1.1.3]",
                "\"hepatic lipase\" NARROW [EC:3.1.1.3]",
                "\"hepatic monoacylglycerol acyltransferase\" NARROW [EC:3.1.1.3]",
                "\"lipazin\" RELATED [EC:3.1.1.3]",
                "\"liver lipase\" NARROW [EC:3.1.1.3]",
                "\"meito MY 30\" RELATED [EC:3.1.1.3]",
                "\"meito sangyo OF lipase\" RELATED [EC:3.1.1.3]",
                "\"post-heparin plasma protamine-resistant lipase\" NARROW [EC:3.1.1.3]",
                "\"PPL\" RELATED [EC:3.1.1.3]",
                "\"salt-resistant post-heparin lipase\" NARROW [EC:3.1.1.3]",
                "\"steapsin\" RELATED [EC:3.1.1.3]",
                "\"TAG activity\" EXACT [PMID:16054079]",
                "\"takedo 1969-4-9\" RELATED [EC:3.1.1.3]",
                "\"triacetinase activity\" RELATED [EC:3.1.1.3]",
                "\"triacylglycerol acylhydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"triacylglycerol ester hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"triacylglycerol lipase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrin esterase activity\" RELATED [EC:3.1.1.3]",
                "\"tributyrinase activity\" RELATED [EC:3.1.1.3]",
                "\"triglyceridase activity\" RELATED [EC:3.1.1.3]",
                "\"triglyceride hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"triolein hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"tween hydrolase activity\" RELATED [EC:3.1.1.3]",
                "\"tween-hydrolyzing esterase activity\" RELATED [EC:3.1.1.3]",
                "\"tweenase activity\" RELATED [EC:3.1.1.3]",
                "\"tweenesterase activity\" RELATED [EC:3.1.1.3]"
              ]
            }
          }
        },
        {
          "id": "GO:0004838",
          "name": "L-tyrosine-2-oxoglutarate transaminase activity",
          "changes": {
            "name": {
              "current": "L-tyrosine-2-oxoglutarate transaminase activity",
              "previous": "L-tyrosine:2-oxoglutarate aminotransferase activity"
            },
            "synonyms": {
              "current": [
                "\"glutamic phenylpyruvic aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"glutamic-hydroxyphenylpyruvic transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"L-phenylalanine 2-oxoglutarate aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"L-tyrosine aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"L-tyrosine transaminase activity\" BROAD []",
                "\"L-tyrosine:2-oxoglutarate aminotransferase activity\" EXACT []",
                "\"phenylalanine aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylalanine transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylalanine-alpha-ketoglutarate transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylpyruvate transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylpyruvic acid transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"TyrAT activity\" RELATED [EC:2.6.1.5]",
                "\"tyrosine aminotransferase activity\" BROAD []",
                "\"tyrosine transaminase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-2-ketoglutarate aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-alpha-ketoglutarate aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-alpha-ketoglutarate transaminase activity\" BROAD [EC:2.6.1.5]"
              ],
              "previous": [
                "\"glutamic phenylpyruvic aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"glutamic-hydroxyphenylpyruvic transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"L-phenylalanine 2-oxoglutarate aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"L-tyrosine aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"phenylalanine aminotransferase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylalanine transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylalanine-alpha-ketoglutarate transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylpyruvate transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"phenylpyruvic acid transaminase activity\" RELATED [EC:2.6.1.5]",
                "\"TyrAT activity\" RELATED [EC:2.6.1.5]",
                "\"tyrosine aminotransferase activity\" BROAD []",
                "\"tyrosine transaminase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-2-ketoglutarate aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-alpha-ketoglutarate aminotransferase activity\" BROAD [EC:2.6.1.5]",
                "\"tyrosine-alpha-ketoglutarate transaminase activity\" BROAD [EC:2.6.1.5]"
              ]
            }
          }
        },
        {
          "id": "GO:0008118",
          "name": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity",
          "changes": {
            "comment": {
              "current": "The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.",
              "previous": "N/A"
            },
            "synonyms": {
              "current": [
                "\"alpha2->3 sialyltransferase activity\" RELATED [EC:2.4.3.6]",
                "\"cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity\" RELATED [EC:2.4.3.6]",
                "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\" EXACT [EC:2.4.3.6]",
                "\"neolactotetraosylceramide alpha-2,3-sialyltransferase activity\" NARROW [EC:2.4.3.6]"
              ],
              "previous": [
                "\"alpha2->3 sialyltransferase activity\" RELATED [EC:2.4.3.6]",
                "\"cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity\" RELATED [EC:2.4.3.6]",
                "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\" EXACT [EC:2.4.3.6]",
                "\"neolactotetraosylceramide alpha-2,3-sialyltransferase activity\" RELATED [EC:2.4.3.6]"
              ]
            }
          }
        },
        {
          "id": "GO:0008131",
          "name": "primary methylamine oxidase activity",
          "changes": {
            "name": {
              "current": "primary methylamine oxidase activity",
              "previous": "primary amine oxidase activity"
            },
            "synonyms": {
              "current": [
                "\"amine oxidase (copper-containing) activity\" NARROW []",
                "\"amine oxidase activity\" BROAD [EC:1.4.3.21]",
                "\"primary amine oxidase activity\" RELATED []",
                "\"primary-amine:oxygen oxidoreductase (deaminating) activity\" EXACT systematic_synonym [EC:1.4.3.21]"
              ],
              "previous": [
                "\"amine oxidase (copper-containing) activity\" NARROW []",
                "\"amine oxidase activity\" BROAD [EC:1.4.3.21]",
                "\"primary-amine:oxygen oxidoreductase (deaminating) activity\" EXACT systematic_synonym [EC:1.4.3.21]"
              ]
            }
          }
        },
        {
          "id": "GO:0008412",
          "name": "4-hydroxybenzoate polyprenyltransferase activity",
          "changes": {
            "name": {
              "current": "4-hydroxybenzoate polyprenyltransferase activity",
              "previous": "4-hydroxybenzoate octaprenyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0008470",
          "name": "3-methylbutanoyl-CoA dehydrogenase activity",
          "changes": {
            "name": {
              "current": "3-methylbutanoyl-CoA dehydrogenase activity",
              "previous": "isovaleryl-CoA dehydrogenase activity"
            },
            "synonyms": {
              "current": [
                "\"3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity\" RELATED [EC:1.3.8.4]",
                "\"3-methylbutanoyl-CoA:acceptor oxidoreductase activity\" RELATED [EC:1.3.8.4]",
                "\"isovaleroyl-coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.4]",
                "\"isovaleryl-CoA dehydrogenase activity\" EXACT []",
                "\"isovaleryl-coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.4]"
              ],
              "previous": [
                "\"3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity\" RELATED [EC:1.3.8.4]",
                "\"3-methylbutanoyl-CoA:acceptor oxidoreductase activity\" RELATED [EC:1.3.8.4]",
                "\"isovaleroyl-coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.4]",
                "\"isovaleryl-coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.4]"
              ]
            }
          }
        },
        {
          "id": "GO:0008660",
          "name": "1-aminocyclopropane-1-carboxylate deaminase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.99.4."
            }
          }
        },
        {
          "id": "GO:0008670",
          "name": "2,4-dienoyl-CoA reductase (NADPH) activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reactions",
              "previous": "\"Catalysis of the reaction"
            }
          }
        },
        {
          "id": "GO:0008676",
          "name": "3-deoxy-8-phosphooctulonate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.2.16."
            }
          }
        },
        {
          "id": "GO:0008700",
          "name": "(R,S)-4-hydroxy-2-oxoglutarate aldolase activity",
          "changes": {
            "name": {
              "current": "(R,S)-4-hydroxy-2-oxoglutarate aldolase activity",
              "previous": "4-hydroxy-2-oxoglutarate aldolase activity"
            },
            "synonyms": {
              "current": [
                "\"2-keto-4-hydroxybutyrate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-keto-4-hydroxyglutarate aldolase activity\" EXACT [EC:4.1.3.16]",
                "\"2-keto-4-hydroxyglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-oxo-4-hydroxyglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-oxo-4-hydroxyglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-ketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-ketoglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-oxoglutarate glyoxylate-lyase activity\" RELATED [EC:4.1.3.16]",
                "\"DL-4-hydroxy-2-ketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"hydroxyketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"hydroxyketoglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"KHG-aldolase activity\" RELATED [EC:4.1.3.16]"
              ],
              "previous": [
                "\"2-keto-4-hydroxybutyrate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-keto-4-hydroxyglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-keto-4-hydroxyglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-oxo-4-hydroxyglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"2-oxo-4-hydroxyglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-ketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-ketoglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)\" RELATED [EC:4.1.3.16]",
                "\"4-hydroxy-2-oxoglutarate glyoxylate-lyase activity\" RELATED [EC:4.1.3.16]",
                "\"DL-4-hydroxy-2-ketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"hydroxyketoglutarate aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"hydroxyketoglutaric aldolase activity\" RELATED [EC:4.1.3.16]",
                "\"KHG-aldolase activity\" RELATED [EC:4.1.3.16]"
              ]
            }
          }
        },
        {
          "id": "GO:0008721",
          "name": "D-serine ammonia-lyase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.3.1.14."
            }
          }
        },
        {
          "id": "GO:0008725",
          "name": "DNA-3-methyladenine glycosylase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"3-methyladenine DNA glycosylase I\" RELATED [EC:3.2.2.20]",
                "\"deoxyribonucleate 3-methyladenine glycosidase I\" RELATED [EC:3.2.2.20]",
                "\"DNA glycosidase I activity\" RELATED [EC:3.2.2.20]",
                "\"DNA-3-methyladenine glycosidase I activity\" RELATED [EC:3.2.2.20]",
                "\"DNA-3-methyladenine glycosylase I activity\" EXACT []"
              ],
              "previous": [
                "\"3-methyladenine DNA glycosylase I\" RELATED [EC:3.2.2.20]",
                "\"alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)\" BROAD [EC:3.2.2.20]",
                "\"deoxyribonucleate 3-methyladenine glycosidase I\" RELATED [EC:3.2.2.20]",
                "\"DNA glycosidase I activity\" RELATED [EC:3.2.2.20]",
                "\"DNA-3-methyladenine glycosidase I activity\" RELATED [EC:3.2.2.20]",
                "\"DNA-3-methyladenine glycosylase I activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0008793",
          "name": "aromatic-amino-acid transaminase activity",
          "changes": {
            "name": {
              "current": "aromatic-amino-acid transaminase activity",
              "previous": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity"
            },
            "synonyms": {
              "current": [
                "\"ArAT\" RELATED [EC:2.6.1.57]",
                "\"aromatic amino acid aminotransferase activity\" EXACT [EC:2.6.1.57]",
                "\"aromatic amino acid transferase activity\" EXACT []",
                "\"aromatic aminotransferase activity\" EXACT []",
                "\"aromatic-amino-acid:2-oxoglutarate aminotransferase activity\" EXACT []"
              ],
              "previous": [
                "\"ArAT\" RELATED [EC:2.6.1.57]",
                "\"aromatic amino acid aminotransferase activity\" RELATED [EC:2.6.1.57]",
                "\"aromatic amino acid transferase activity\" EXACT []",
                "\"aromatic aminotransferase activity\" EXACT []",
                "\"aromatic-amino-acid transaminase activity\" RELATED [EC:2.6.1.57]"
              ]
            }
          }
        },
        {
          "id": "GO:0008824",
          "name": "cyanate hydratase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.3.99.1."
            }
          }
        },
        {
          "id": "GO:0008876",
          "name": "quinoprotein glucose dehydrogenase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.99.17."
            }
          }
        },
        {
          "id": "GO:0008901",
          "name": "ferredoxin hydrogenase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.12.1.1, EC:1.12.7.1, EC:1.98.1.1, EC:1.18.3.1 and EC:1.18.99.1."
            }
          }
        },
        {
          "id": "GO:0008909",
          "name": "isochorismate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:5.4.99.6."
            }
          }
        },
        {
          "id": "GO:0009011",
          "name": "alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity",
          "changes": {
            "name": {
              "current": "alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity",
              "previous": "starch synthase activity"
            },
            "synonyms": {
              "current": [
                "\"adenosine diphosphate glucose-starch glucosyltransferase activity\" EXACT []",
                "\"adenosine diphosphoglucose-starch glucosyltransferase activity\" EXACT []",
                "\"ADP-glucose starch synthase activity\" RELATED [EC:2.4.1.21]",
                "\"ADP-glucose transglucosylase activity\" EXACT []",
                "\"ADP-glucose--starch glucosyltransferase activity\" RELATED [EC:2.4.1.21]",
                "\"ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity\" EXACT []",
                "\"ADPG starch synthetase activity\" EXACT []",
                "\"ADPG-starch glucosyltransferase activity\" EXACT []",
                "\"ADPglucose-starch glucosyltransferase activity\" EXACT []",
                "\"ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity\" EXACT []",
                "\"glycogen synthase activity\" RELATED [EC:2.4.1.21]",
                "\"starch (bacterial glycogen) synthase activity\" NARROW [EC:2.4.1.21]",
                "\"starch synthase activity\" EXACT []",
                "\"starch synthetase activity\" EXACT []"
              ],
              "previous": [
                "\"adenosine diphosphate glucose-starch glucosyltransferase activity\" EXACT []",
                "\"adenosine diphosphoglucose-starch glucosyltransferase activity\" EXACT []",
                "\"ADP-glucose starch synthase activity\" RELATED [EC:2.4.1.21]",
                "\"ADP-glucose transglucosylase activity\" EXACT []",
                "\"ADP-glucose--starch glucosyltransferase activity\" RELATED [EC:2.4.1.21]",
                "\"ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity\" EXACT []",
                "\"ADPG starch synthetase activity\" EXACT []",
                "\"ADPG-starch glucosyltransferase activity\" EXACT []",
                "\"ADPglucose-starch glucosyltransferase activity\" EXACT []",
                "\"ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity\" EXACT []",
                "\"glycogen synthase activity\" RELATED [EC:2.4.1.21]",
                "\"starch (bacterial glycogen) synthase activity\" NARROW [EC:2.4.1.21]",
                "\"starch synthetase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0009931",
          "name": "calcium-dependent protein serine/threonine kinase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "These reactions are dependent on the presence of calcium ions."
            }
          }
        },
        {
          "id": "GO:0010945",
          "name": "coenzyme A diphosphatase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate.\" [PMID:10922370, PMID:16185196, RHEA:50044]"
            }
          }
        },
        {
          "id": "GO:0015451",
          "name": "decarboxylation-driven active transmembrane transporter activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"decarboxylation-driven transporter\" EXACT []"
              ],
              "previous": [
                "\"decarboxylation-driven transporter\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0016231",
          "name": "beta-N-acetylglucosaminidase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides.\" [EC:3.2.1.52]",
              "previous": "\"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides.\" [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]"
            }
          }
        },
        {
          "id": "GO:0016298",
          "name": "lipase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the hydrolysis of a lipid.\" [GOC:mah, ISBN:0198506732]",
              "previous": "\"Catalysis of the hydrolysis of a lipid or phospholipid.\" [GOC:mah, ISBN:0198506732]"
            }
          }
        },
        {
          "id": "GO:0016412",
          "name": "serine O-acyltransferase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.\" [GOC:ai]"
            }
          }
        },
        {
          "id": "GO:0016652",
          "name": "oxidoreductase activity, acting on NAD(P)H as acceptor",
          "changes": {
            "name": {
              "current": "oxidoreductase activity, acting on NAD(P)H as acceptor",
              "previous": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"
            },
            "definition": {
              "current": "\"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP.\" [EC:1.6.1.-]",
              "previous": "\"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP.\" [GOC:ai]"
            }
          }
        },
        {
          "id": "GO:0016712",
          "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
          "changes": {
            "synonyms": {
              "current": [
                "\"aryl hydrocarbon hydroxylase activity\" NARROW [EC:1.14.14.1]",
                "\"aryl-4-monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"cytochrome p450 activity\" NARROW [EC:1.14.14.1]",
                "\"cytochrome P450 CYP19\" NARROW []",
                "\"flavoprotein monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"flavoprotein-linked monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"microsomal monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"microsomal P-450\" NARROW [EC:1.14.14.1]",
                "\"microsomal p450 activity\" NARROW [EC:1.14.14.1]",
                "\"substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)\" RELATED [EC:1.14.14.1]",
                "\"unspecific monooxygenase activity\" NARROW []",
                "\"xenobiotic monooxygenase activity\" NARROW [EC:1.14.14.1]"
              ],
              "previous": [
                "\"aryl hydrocarbon hydroxylase activity\" NARROW [EC:1.14.14.1]",
                "\"aryl-4-monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"cytochrome p450 activity\" NARROW [EC:1.14.14.1]",
                "\"cytochrome P450 CYP19\" NARROW []",
                "\"flavoprotein monooxygenase activity\" RELATED [EC:1.14.14.1]",
                "\"flavoprotein-linked monooxygenase activity\" RELATED [EC:1.14.14.1]",
                "\"microsomal monooxygenase activity\" NARROW [EC:1.14.14.1]",
                "\"microsomal P-450\" RELATED [EC:1.14.14.1]",
                "\"microsomal p450 activity\" NARROW [EC:1.14.14.1]",
                "\"substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)\" RELATED [EC:1.14.14.1]",
                "\"unspecific monooxygenase activity\" RELATED []",
                "\"xenobiotic monooxygenase activity\" RELATED [EC:1.14.14.1]"
              ]
            }
          }
        },
        {
          "id": "GO:0016759",
          "name": "cellulose synthase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"cellulose synthetase activity\" RELATED []"
              ],
              "previous": [
                "\"cellulose synthetase activity\" RELATED [EC:2.4.1.29]"
              ]
            }
          }
        },
        {
          "id": "GO:0016779",
          "name": "nucleotidyltransferase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).\" [EC:2.7.7.-]",
              "previous": "\"Catalysis of the transfer of a nucleotidyl group to a reactant.\" [ISBN:0198506732]"
            }
          }
        },
        {
          "id": "GO:0016841",
          "name": "ammonia-lyase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.\" [GOC:krc]",
              "previous": "\"Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.\" [EC:4.3.-.-, GOC:krc]"
            }
          }
        },
        {
          "id": "GO:0016842",
          "name": "amidine-lyase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate.\" [GOC:krc]",
              "previous": "\"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate.\" [EC:4.3.-.-, GOC:krc]"
            }
          }
        },
        {
          "id": "GO:0016843",
          "name": "amine-lyase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate.\" [GOC:krc]",
              "previous": "\"Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate.\" [EC:4.3.-.-, GOC:krc]"
            }
          }
        },
        {
          "id": "GO:0016847",
          "name": "1-aminocyclopropane-1-carboxylate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.99.4."
            }
          }
        },
        {
          "id": "GO:0017040",
          "name": "N-acylsphingosine amidohydrolase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"acylsphingosine deacylase activity\" RELATED [EC:3.5.1.23]",
                "\"ceramidase activity\" NARROW []",
                "\"glycosphingolipid ceramide deacylase\" BROAD [EC:3.5.1.23]"
              ],
              "previous": [
                "\"acylsphingosine deacylase activity\" RELATED [EC:3.5.1.23]",
                "\"glycosphingolipid ceramide deacylase\" BROAD [EC:3.5.1.23]"
              ]
            }
          }
        },
        {
          "id": "GO:0018684",
          "name": "2,5-diketocamphane 1,2-monooxygenase",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.15.2."
            }
          }
        },
        {
          "id": "GO:0019010",
          "name": "farnesoic acid O-methyltransferase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"juvenile hormone acid methyltransferase activity\" EXACT []",
                "\"juvenile hormone-III synthase activity\" EXACT []",
                "\"S-adenosyl-methionine:farnesoic acid O-methyltransferase activity\" EXACT []"
              ],
              "previous": [
                "\"S-adenosyl-methionine:farnesoic acid O-methyltransferase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0019142",
          "name": "2-hydroxyglutarate synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.9."
            }
          }
        },
        {
          "id": "GO:0030058",
          "name": "aliphatic amine dehydrogenase activity",
          "changes": {
            "name": {
              "current": "aliphatic amine dehydrogenase activity",
              "previous": "amine dehydrogenase activity"
            },
            "synonyms": {
              "current": [
                "\"amine dehydrogenase activity\" BROAD []",
                "\"amine",
                "\"MADH activity\" RELATED []",
                "\"methylamine dehydrogenase activity\" RELATED []",
                "\"primary-amine dehydrogenase activity\" BROAD []",
                "\"primary-amine:acceptor oxidoreductase (deaminating)\" RELATED []"
              ],
              "previous": [
                "\"amine",
                "\"MADH activity\" RELATED []",
                "\"methylamine dehydrogenase activity\" RELATED []",
                "\"primary-amine dehydrogenase activity\" BROAD []",
                "\"primary-amine:acceptor oxidoreductase (deaminating)\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0030586",
          "name": "[methionine synthase] reductase (NADPH) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:2.1.1.135."
            }
          }
        },
        {
          "id": "GO:0030674",
          "name": "protein-macromolecule adaptor activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"protein binding, bridging\" EXACT []",
                "\"protein complex scaffold activity\" BROAD []",
                "\"protein recruiting activity\" RELATED []",
                "\"protein-containing complex scaffold activity\" BROAD []",
                "\"protein-protein adaptor\" NARROW []"
              ],
              "previous": [
                "\"protein binding, bridging\" EXACT []",
                "\"protein recruiting activity\" RELATED []",
                "\"protein-protein adaptor\" NARROW []"
              ]
            }
          }
        },
        {
          "id": "GO:0032942",
          "name": "inositol-1,4,5,6-tetrakisphosphate 2-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,4,5,6-tetrakisphosphate 2-kinase activity",
              "previous": "inositol tetrakisphosphate 2-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-tetrakisphosphate 2-kinase activity\" BROAD []",
                "\"inositol tetrakisphosphate 2-kinase activity\" BROAD []",
                "\"inositol-tetrakisphosphate 2-kinase activity\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-tetrakisphosphate 2-kinase activity\" EXACT []",
                "\"inositol 1,3,4,6-tetrakisphosphate 2-kinase activity\" EXACT []",
                "\"inositol-tetrakisphosphate 2-kinase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0033200",
          "name": "diphosphoinositol pentakisphosphate 5-kinase activity",
          "changes": {
            "name": {
              "current": "diphosphoinositol pentakisphosphate 5-kinase activity",
              "previous": "inositol heptakisphosphate 5-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"diphosphoinositol-pentakisphosphate 5-kinase activity\" EXACT []",
                "\"inositol heptakisphosphate 5-kinase activity\" EXACT []",
                "\"IP7 5-kinase activity\" EXACT []"
              ],
              "previous": [
                "\"diphosphoinositol-pentakisphosphate 5-kinase activity\" EXACT []",
                "\"IP7 5-kinase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0033773",
          "name": "isoflavone 2'-hydroxylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.13.89."
            }
          }
        },
        {
          "id": "GO:0033782",
          "name": "24-hydroxycholesterol 7alpha-hydroxylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.13.99."
            }
          }
        },
        {
          "id": "GO:0033787",
          "name": "cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.6.99.12."
            }
          }
        },
        {
          "id": "GO:0033792",
          "name": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity",
          "changes": {
            "comment": {
              "current": "Note that this was originally described as bile acid 7-dehydroxylase (PubMed:3549693). In fact, the 7-dehydroxylation process is catalyzed by multiple enzymes.",
              "previous": "Formerly EC:1.17.99.5. Was originally described as bile acid 7-dehydroxylase (PubMed:3549693). In fact, the 7-dehydroxylation process is catalyzed by multiple enzymes."
            }
          }
        },
        {
          "id": "GO:0033799",
          "name": "myricetin 3'-O-methyltransferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267"
            }
          }
        },
        {
          "id": "GO:0033840",
          "name": "alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity",
          "changes": {
            "name": {
              "current": "alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity",
              "previous": "NDP-glucose-starch glucosyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0033857",
          "name": "5-diphosphoinositol pentakisphosphate 1-kinase activity",
          "changes": {
            "name": {
              "current": "5-diphosphoinositol pentakisphosphate 1-kinase activity",
              "previous": "diphosphoinositol-pentakisphosphate kinase activity"
            },
            "synonyms": {
              "current": [
                "\"diphosphoinositol-pentakisphosphate kinase activity\" BROAD []",
                "\"inositol heptakisphosphate 1-kinase activity\" BROAD []",
                "\"PP-InsP5 kinase activity\" RELATED [EC:2.7.4.24]",
                "\"PP-IP5 kinase activity\" RELATED [EC:2.7.4.24]",
                "\"PPIP5K\" RELATED []"
              ],
              "previous": [
                "\"5-diphosphoinositol pentakisphosphate 3-kinase activity\" EXACT []",
                "\"PP-InsP5 kinase activity\" RELATED [EC:2.7.4.24]",
                "\"PP-IP5 kinase activity\" RELATED [EC:2.7.4.24]",
                "\"PPIP5K\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0033881",
          "name": "bile-acid-CoA transferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:3.1.2.26 and RHEA:17693."
            }
          }
        },
        {
          "id": "GO:0033897",
          "name": "ribonuclease T2 activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.\" [EC:4.6.1.19]"
            }
          }
        },
        {
          "id": "GO:0033987",
          "name": "2-hydroxyisoflavanone dehydratase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reactions",
              "previous": "\"Catalysis of the reaction"
            }
          }
        },
        {
          "id": "GO:0034061",
          "name": "DNA polymerase activity",
          "changes": {
            "synonyms": {
              "current": "N/A",
              "previous": [
                "\"deoxynucleate polymerase activity\" RELATED [EC:2.7.7.7]",
                "\"deoxyribonucleate nucleotidyltransferase activity\" RELATED [EC:2.7.7.7]",
                "\"deoxyribonucleic acid polymerase activity\" RELATED [EC:2.7.7.7]",
                "\"deoxyribonucleic polymerase activity\" RELATED [EC:2.7.7.7]",
                "\"DNA nucleotidyltransferase activity\" RELATED [EC:2.7.7.7]"
              ]
            }
          }
        },
        {
          "id": "GO:0034317",
          "name": "nicotinate riboside kinase activity",
          "changes": {
            "name": {
              "current": "nicotinate riboside kinase activity",
              "previous": "nicotinic acid riboside kinase activity"
            },
            "synonyms": {
              "current": [
                "\"nicotinic acid riboside kinase\" EXACT []",
                "\"ribosylnicotinic acid kinase\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0035299",
          "name": "inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity",
              "previous": "inositol pentakisphosphate 2-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"inositol hexakisphosphate synthase\" RELATED []",
                "\"inositol pentakisphosphate 2-kinase activity\" EXACT []",
                "\"inositol polyphosphate kinase activity\" RELATED [EC:2.7.1.158]",
                "\"inositol-pentakisphosphate 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"Ins(1,3,4,5,6)P5 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"IP5 2-kinase activity\" RELATED [EC:2.7.1.158]"
              ],
              "previous": [
                "\"Gsl1p\" RELATED [EC:2.7.1.158]",
                "\"inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"inositol hexakisphosphate synthase\" RELATED []",
                "\"inositol polyphosphate kinase activity\" RELATED [EC:2.7.1.158]",
                "\"inositol-pentakisphosphate 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"Ins(1,3,4,5,6)P5 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"IP5 2-kinase activity\" RELATED [EC:2.7.1.158]",
                "\"Ipk1p\" RELATED [EC:2.7.1.158]"
              ]
            }
          }
        },
        {
          "id": "GO:0036209",
          "name": "9beta-pimara-7,15-diene oxidase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.13.144."
            }
          }
        },
        {
          "id": "GO:0036397",
          "name": "formate dehydrogenase (quinone) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.5.6."
            }
          }
        },
        {
          "id": "GO:0043860",
          "name": "cyanophycin synthetase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).\" [GOC:jl]",
              "previous": "\"Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).\" [EC:6.3.2.29, EC:6.3.2.30, GOC:jl]"
            }
          }
        },
        {
          "id": "GO:0043891",
          "name": "glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity",
          "changes": {
            "name": {
              "current": "glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity",
              "previous": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"
            }
          }
        },
        {
          "id": "GO:0045486",
          "name": "flavanone 3-dioxygenase activity",
          "changes": {
            "name": {
              "current": "flavanone 3-dioxygenase activity",
              "previous": "naringenin 3-dioxygenase activity"
            },
            "synonyms": {
              "current": [
                "\"(2S)-flavanone 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3-beta-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3beta-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone synthase I activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)\" RELATED [EC:1.14.11.9]",
                "\"naringenin 3-dioxygenase activity\" NARROW []",
                "\"naringenin 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity\" RELATED [EC:1.14.11.9]"
              ],
              "previous": [
                "\"(2S)-flavanone 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3-beta-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3-dioxygenase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone 3beta-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone synthase I activity\" RELATED [EC:1.14.11.9]",
                "\"flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)\" RELATED [EC:1.14.11.9]",
                "\"naringenin 3-hydroxylase activity\" RELATED [EC:1.14.11.9]",
                "\"naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity\" RELATED [EC:1.14.11.9]"
              ]
            }
          }
        },
        {
          "id": "GO:0046428",
          "name": "1,4-dihydroxy-2-naphthoate polyprenyltransferase activity",
          "changes": {
            "name": {
              "current": "1,4-dihydroxy-2-naphthoate polyprenyltransferase activity",
              "previous": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"1,4-dihydroxy-2-naphtoate prenyltransferase activity\" EXACT []"
              ],
              "previous": [
                "\"1,4-Dihydroxy-2-naphtoate prenyltransferase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0046589",
          "name": "ribonuclease T1 activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates.\" [EC:4.6.1.24]",
              "previous": "\"Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates.\" [GOC:curators]"
            }
          }
        },
        {
          "id": "GO:0047040",
          "name": "pteridine reductase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:1.1.1.253."
            }
          }
        },
        {
          "id": "GO:0047057",
          "name": "vitamin-K-epoxide reductase (warfarin-sensitive) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.4.1."
            }
          }
        },
        {
          "id": "GO:0047058",
          "name": "vitamin-K-epoxide reductase (warfarin-insensitive) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.4.2."
            }
          }
        },
        {
          "id": "GO:0047059",
          "name": "polyvinyl alcohol dehydrogenase (cytochrome) activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.99.23."
            }
          }
        },
        {
          "id": "GO:0047183",
          "name": "anthocyanin 5-(6'''-hydroxycinnamoyltransferase) activity",
          "changes": {
            "name": {
              "current": "anthocyanin 5-(6'''-hydroxycinnamoyltransferase) activity",
              "previous": "anthocyanin 5-aromatic acyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"anthocyanin 5-aromatic acyltransferase activity\" EXACT []",
                "\"hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity\" RELATED [EC:2.3.1.153]"
              ],
              "previous": [
                "\"hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity\" RELATED [EC:2.3.1.153]"
              ]
            }
          }
        },
        {
          "id": "GO:0047312",
          "name": "L-phenylalanine-pyruvate transaminase activity",
          "changes": {
            "name": {
              "current": "L-phenylalanine-pyruvate transaminase activity",
              "previous": "L-phenylalanine:pyruvate aminotransferase activity"
            },
            "synonyms": {
              "current": [
                "\"histidine aminotransferase activity\" RELATED [GOC:kad]",
                "\"histidine:pyruvate aminotransferase activity\" RELATED [EC:2.6.1.58, GOC:kad]",
                "\"L-histidine:pyruvate aminotransferase activity\" RELATED [GOC:kad]",
                "\"L-phenylalanine(L-histidine):pyruvate aminotransferase activity\" BROAD [EC:2.6.1.58]",
                "\"L-phenylalanine:pyruvate aminotransferase activity\" EXACT []",
                "\"L-phenylalanine:pyruvate transaminase activity\" EXACT [GOC:kad]",
                "\"phenylalanine (histidine) aminotransferase activity\" BROAD [EC:2.6.1.58]",
                "\"phenylalanine(histidine) aminotransferase activity\" BROAD []",
                "\"phenylalanine(histidine) transaminase activity\" BROAD [EC:2.6.1.58]",
                "\"phenylalanine(histidine):pyruvate aminotransferase activity\" BROAD [EC:2.6.1.58]"
              ],
              "previous": [
                "\"histidine aminotransferase activity\" RELATED [GOC:kad]",
                "\"histidine:pyruvate aminotransferase activity\" RELATED [EC:2.6.1.58, GOC:kad]",
                "\"L-histidine:pyruvate aminotransferase activity\" RELATED [GOC:kad]",
                "\"L-phenylalanine(L-histidine):pyruvate aminotransferase activity\" BROAD [EC:2.6.1.58]",
                "\"L-phenylalanine:pyruvate transaminase activity\" EXACT [GOC:kad]",
                "\"phenylalanine (histidine) aminotransferase activity\" BROAD [EC:2.6.1.58]",
                "\"phenylalanine(histidine) aminotransferase activity\" BROAD []",
                "\"phenylalanine(histidine) transaminase activity\" BROAD [EC:2.6.1.58]",
                "\"phenylalanine(histidine):pyruvate aminotransferase activity\" BROAD [EC:2.6.1.58]"
              ]
            }
          }
        },
        {
          "id": "GO:0047325",
          "name": "inositol-3,4,5,6-tetrakisphosphate 1-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-3,4,5,6-tetrakisphosphate 1-kinase activity",
              "previous": "inositol tetrakisphosphate 1-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-tetrakisphosphate 1-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"1D-myo-inositol-trisphosphate 5-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"1D-myo-inositol-trisphosphate 6-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity\" RELATED [EC:2.7.1.134]",
                "\"inositol 3,4,5,6-tetrakisphosphate 1-kinase activity\" EXACT []",
                "\"inositol tetrakisphosphate 1-kinase activity\" BROAD []",
                "\"inositol-trisphosphate 5-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"inositol-trisphosphate 6-kinase activity\" RELATED [EC:2.7.1.134]"
              ],
              "previous": [
                "\"1D-myo-inositol-tetrakisphosphate 1-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"1D-myo-inositol-trisphosphate 5-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"1D-myo-inositol-trisphosphate 6-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity\" RELATED [EC:2.7.1.134]",
                "\"inositol 3,4,5,6-tetrakisphosphate 1-kinase activity\" EXACT []",
                "\"inositol-tetrakisphosphate 1-kinase activity\" BROAD []",
                "\"inositol-trisphosphate 5-kinase activity\" RELATED [EC:2.7.1.134]",
                "\"inositol-trisphosphate 6-kinase activity\" RELATED [EC:2.7.1.134]"
              ]
            }
          }
        },
        {
          "id": "GO:0047326",
          "name": "inositol-1,3,4,6-tetrakisphosphate 5-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,3,4,6-tetrakisphosphate 5-kinase activity",
              "previous": "inositol tetrakisphosphate 5-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-tetrakisphosphate 5-kinase activity\" BROAD []",
                "\"ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity\" RELATED [EC:2.7.1.140]",
                "\"inositol 1,3,4,6-tetrakisphosphate 5-kinase activity\" EXACT []",
                "\"inositol tetrakisphosphate 5-kinase activity\" BROAD []",
                "\"inositol-tetrakisphosphate 5-kinase activity\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-tetrakisphosphate 5-kinase activity\" EXACT []",
                "\"ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity\" RELATED [EC:2.7.1.140]",
                "\"inositol 1,3,4,6-tetrakisphosphate 5-kinase activity\" EXACT []",
                "\"inositol-tetrakisphosphate 5-kinase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0047372",
          "name": "monoacylglycerol lipase activity",
          "changes": {
            "name": {
              "current": "monoacylglycerol lipase activity",
              "previous": "acylglycerol lipase activity"
            },
            "synonyms": {
              "current": [
                "\"acylglycerol lipase activity\" BROAD []",
                "\"fatty acyl monoester lipase activity\" RELATED [EC:3.1.1.23]",
                "\"glycerol-ester acylhydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoacylglycerol hydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoacylglycerolipase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceridase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceride hydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceride lipase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceridyllipase activity\" RELATED [EC:3.1.1.23]"
              ],
              "previous": [
                "\"fatty acyl monoester lipase activity\" RELATED [EC:3.1.1.23]",
                "\"glycerol-ester acylhydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoacylglycerol hydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoacylglycerol lipase activity\" RELATED [EC:3.1.1.23]",
                "\"monoacylglycerolipase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceridase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceride hydrolase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceride lipase activity\" RELATED [EC:3.1.1.23]",
                "\"monoglyceridyllipase activity\" RELATED [EC:3.1.1.23]"
              ]
            }
          }
        },
        {
          "id": "GO:0047388",
          "name": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:3.1.4.15, MetaCyc:3.1.4.15-RXN."
            }
          }
        },
        {
          "id": "GO:0047443",
          "name": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reactions",
              "previous": "\"Catalysis of the reaction"
            }
          }
        },
        {
          "id": "GO:0047522",
          "name": "15-oxoprostaglandin 13-oxidase [NAD(P)+] activity",
          "changes": {
            "name": {
              "current": "15-oxoprostaglandin 13-oxidase [NAD(P)+] activity",
              "previous": "15-oxoprostaglandin 13-oxidase activity"
            },
            "comment": {
              "current": "N/A",
              "previous": "Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'."
            },
            "synonyms": {
              "current": [
                "\"(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity\" EXACT [EC:1.3.1.48]",
                "\"15-oxo-Delta(13)-prostaglandin reductase activity\" EXACT []",
                "\"15-oxoprostaglandin 13-oxidase activity\" EXACT []"
              ],
              "previous": [
                "\"(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity\" RELATED [EC:1.3.1.48]"
              ]
            }
          }
        },
        {
          "id": "GO:0047592",
          "name": "5-pyridoxate dioxygenase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.12.5."
            }
          }
        },
        {
          "id": "GO:0047606",
          "name": "(S)-hydroxynitrile lyase activity",
          "changes": {
            "name": {
              "current": "(S)-hydroxynitrile lyase activity",
              "previous": "hydroxynitrilase activity"
            },
            "synonyms": {
              "current": [
                "\"alpha-hydroxynitrile lyase activity\" NARROW []",
                "\"hydroxynitrilase activity\" BROAD []",
                "\"hydroxynitrile lyase activity\" EXACT []",
                "\"oxynitrilase activity\" RELATED []"
              ],
              "previous": [
                "\"alpha-hydroxynitrile lyase activity\" NARROW []",
                "\"hydroxynitrile lyase activity\" EXACT []",
                "\"oxynitrilase activity\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0047810",
          "name": "D-alanine-2-oxoglutarate aminotransferase activity",
          "changes": {
            "name": {
              "current": "D-alanine-2-oxoglutarate aminotransferase activity",
              "previous": "D-alanine:2-oxoglutarate aminotransferase activity"
            }
          }
        },
        {
          "id": "GO:0047856",
          "name": "dihydrocoumarin hydrolase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"3,4-dihydrocoumarin hydrolase activity\" EXACT []",
                "\"dihydrocoumarin lactonohydrolase activity\" RELATED [EC:3.1.1.35]",
                "\"dihydrocoumarin lipase activity\" EXACT []"
              ],
              "previous": [
                "\"dihydrocoumarin lactonohydrolase activity\" RELATED [EC:3.1.1.35]",
                "\"dihydrocoumarin lipase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0050012",
          "name": "juglone 3-hydroxylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.14.99.27."
            }
          }
        },
        {
          "id": "GO:0050079",
          "name": "acetylenecarboxylate hydratase activity",
          "changes": {
            "name": {
              "current": "acetylenecarboxylate hydratase activity",
              "previous": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate"
            },
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.2.1.71."
            },
            "synonyms": {
              "current": [
                "\"3-oxopropanoate hydro-lyase (propynoate-forming)\" RELATED [EC:4.2.1.27]",
                "\"3-oxopropanoate hydro-lyase activity\" RELATED [EC:4.2.1.27]",
                "\"acetylenecarboxylate hydratase activity, producing malonate-semialdehyde\" NARROW []",
                "\"acetylenemonocarboxylate hydrase activity\" RELATED [EC:4.2.1.27]",
                "\"acetylenemonocarboxylate hydratase activity\" BROAD []",
                "\"acetylmonocarboxylic acid hydrase activity\" RELATED [EC:4.2.1.27]",
                "\"alkynoate hydratase activity\" BROAD []",
                "\"malonate-semialdehyde dehydratase activity\" RELATED []"
              ],
              "previous": [
                "\"3-oxopropanoate hydro-lyase (propynoate-forming)\" RELATED [EC:4.2.1.27]",
                "\"3-oxopropanoate hydro-lyase activity\" RELATED [EC:4.2.1.27]",
                "\"acetylenecarboxylate hydratase activity\" BROAD []",
                "\"acetylenecarboxylate hydratase activity, producing malonate-semialdehyde\" EXACT []",
                "\"acetylenemonocarboxylate hydrase activity\" RELATED [EC:4.2.1.27]",
                "\"acetylenemonocarboxylate hydratase activity\" BROAD []",
                "\"acetylmonocarboxylic acid hydrase activity\" RELATED [EC:4.2.1.27]",
                "\"alkynoate hydratase activity\" BROAD []",
                "\"malonate-semialdehyde dehydratase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0050232",
          "name": "putrescine oxidase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"putrescine:oxygen oxidoreductase (deaminating)\" EXACT [EC:1.4.3.10]"
              ],
              "previous": [
                "\"putrescine:oxygen oxidoreductase (deaminating)\" RELATED [EC:1.4.3.10]"
              ]
            }
          }
        },
        {
          "id": "GO:0050297",
          "name": "stizolobate synthase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)\" RELATED [EC:1.13.11.29]",
                "\"DOPA dioxygenase activity\" EXACT []"
              ],
              "previous": [
                "\"3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)\" RELATED [EC:1.13.11.29]"
              ]
            }
          }
        },
        {
          "id": "GO:0050404",
          "name": "zeatin O-beta-D-xylosyltransferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:2.4.1.204."
            }
          }
        },
        {
          "id": "GO:0050697",
          "name": "trichloroethene reductive dehalogenase activity",
          "changes": {
            "name": {
              "current": "trichloroethene reductive dehalogenase activity",
              "previous": "1,1,2-trichloroethene reductive dehalogenase activity"
            },
            "synonyms": {
              "current": [
                "\"1,1,2-trichloroethene reductive dehalogenase activity\" EXACT []",
                "\"1,1,2-trichloroethylene reductive dehalogenase activity\" EXACT []",
                "\"TCE-reductive dehalogenase activity\" EXACT []"
              ],
              "previous": [
                "\"1,1,2-trichloroethylene reductive dehalogenase activity\" EXACT []",
                "\"TCE-reductive dehalogenase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0051269",
          "name": "alpha-ketoester reductase (NADPH) activity",
          "changes": {
            "name": {
              "current": "alpha-ketoester reductase (NADPH) activity",
              "previous": "alpha-keto ester reductase activity"
            }
          }
        },
        {
          "id": "GO:0051566",
          "name": "anthocyanidin 3-glucoside rhamnosyltransferase activity",
          "changes": {
            "name": {
              "current": "anthocyanidin 3-glucoside rhamnosyltransferase activity",
              "previous": "anthocyanidin-3-glucoside rhamnosyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0052381",
          "name": "tRNA dimethylallyltransferase activity",
          "changes": {
            "comment": {
              "current": "Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.",
              "previous": "Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC:2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate."
            }
          }
        },
        {
          "id": "GO:0052577",
          "name": "germacrene-D synthase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-germacrene-D-forming] activity\" EXACT [EC:4.2.3.75]"
              ],
              "previous": [
                "\"2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity\" RELATED [EC:4.2.3.22]"
              ]
            }
          }
        },
        {
          "id": "GO:0052579",
          "name": "(+)-pulegone reductase (NADP+) activity",
          "changes": {
            "name": {
              "current": "(+)-pulegone reductase (NADP+) activity",
              "previous": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity"
            }
          }
        },
        {
          "id": "GO:0052625",
          "name": "N-(4-aminobenzoyl)-L-glutamate synthetase activity",
          "changes": {
            "name": {
              "current": "N-(4-aminobenzoyl)-L-glutamate synthetase activity",
              "previous": "4-aminobenzoate amino acid synthetase activity"
            },
            "synonyms": {
              "current": [
                "\"4-aminobenzoate amino acid synthetase activity\" BROAD []",
                "\"4-aminobenzoyl amino acid synthetase activity\" EXACT []",
                "\"p-aminobenzoate amino acid synthetase activity\" EXACT []",
                "\"p-aminobenzoyl amino acid synthetase activity\" EXACT []",
                "\"pABA amino acid synthetase activity\" EXACT []"
              ],
              "previous": [
                "\"4-aminobenzoyl amino acid synthetase activity\" EXACT []",
                "\"p-aminobenzoate amino acid synthetase activity\" EXACT []",
                "\"p-aminobenzoyl amino acid synthetase activity\" EXACT []",
                "\"pABA amino acid synthetase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0052626",
          "name": "N-benzoyl-L-glutamate synthetase activity",
          "changes": {
            "name": {
              "current": "N-benzoyl-L-glutamate synthetase activity",
              "previous": "benzoate amino acid synthetase activity"
            },
            "synonyms": {
              "current": [
                "\"benzoate amino acid synthetase activity\" BROAD []",
                "\"benzoyl amino acid synthetase activity\" EXACT []"
              ],
              "previous": [
                "\"benzoyl amino acid synthetase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0052627",
          "name": "N-vanillate-L-glutamate synthetase activity",
          "changes": {
            "name": {
              "current": "N-vanillate-L-glutamate synthetase activity",
              "previous": "vanillate amino acid synthetase activity"
            },
            "synonyms": {
              "current": [
                "\"vanillate amino acid synthetase activity\" BROAD []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052628",
          "name": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity",
          "changes": {
            "name": {
              "current": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity",
              "previous": "4-hydroxybenzoate amino acid synthetase activity"
            },
            "synonyms": {
              "current": [
                "\"4-hydroxybenzoate amino acid synthetase activity\" BROAD []",
                "\"4-hydroxybenzoyl amino acid synthetase activity\" EXACT []",
                "\"4HBA amino acid synthetase activity\" EXACT []",
                "\"p-hydroxybenzoate amino acid synthetase activity\" EXACT []",
                "\"p-hydroxybenzoyl amino acid synthetase activity\" EXACT []"
              ],
              "previous": [
                "\"4-hydroxybenzoyl amino acid synthetase activity\" EXACT []",
                "\"4HBA amino acid synthetase activity\" EXACT []",
                "\"p-hydroxybenzoate amino acid synthetase activity\" EXACT []",
                "\"p-hydroxybenzoyl amino acid synthetase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0052662",
          "name": "zeaxanthin epoxidase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Multi-step reaction"
            }
          }
        },
        {
          "id": "GO:0052706",
          "name": "L-histidine N(alpha)-methyltransferase activity",
          "changes": {
            "name": {
              "current": "L-histidine N(alpha)-methyltransferase activity",
              "previous": "histidine N-methyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"histidine methyltransferase activity\" EXACT [EC:2.1.1.44]",
                "\"histidine N-methyltransferase activity\" EXACT []",
                "\"histidine-alpha-N-methyltransferase activity\" EXACT [EC:2.1.1.44]",
                "\"S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity\" EXACT [EC:2.1.1.44]",
                "\"S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity\" EXACT [EC:2.1.1.44]"
              ],
              "previous": [
                "\"histidine methyltransferase activity\" RELATED [EC:2.1.1.44]",
                "\"histidine-alpha-N-methyltransferase activity\" BROAD [EC:2.1.1.44]",
                "\"S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity\" RELATED [EC:2.1.1.44]",
                "\"S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity\" RELATED [EC:2.1.1.44]"
              ]
            }
          }
        },
        {
          "id": "GO:0052725",
          "name": "inositol-1,3,4-trisphosphate 6-kinase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-trisphosphate 6-kinase activity\" BROAD []",
                "\"inositol 1,3,4-trisphosphate 6-kinase activity\" EXACT []",
                "\"inositol-trisphosphate 6-kinase activity\" BROAD []",
                "\"ins(1,3,4)P(3) 6-kinase activity\" RELATED []",
                "\"Ins(1,3,4)P3 6-kinase activity\" RELATED []",
                "\"IP3 6-kinase activity\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-trisphosphate 6-kinase activity\" BROAD []",
                "\"inositol 1,3,4-trisphosphate 6-kinase activity\" EXACT []",
                "\"inositol-trisphosphate 6-kinase activity\" BROAD []",
                "\"ins(1,3,4)P(3) 6-kinase activity\" RELATED [EC:2.7.1.127]",
                "\"Ins(1,3,4)P3 6-kinase activity\" RELATED [EC:2.7.1.127]",
                "\"IP3 6-kinase activity\" BROAD [EC:2.7.1.127]"
              ]
            }
          }
        },
        {
          "id": "GO:0052726",
          "name": "inositol-1,3,4-trisphosphate 5-kinase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-trisphosphate 5-kinase activity\" BROAD []",
                "\"inositol 1,3,4-trisphosphate 5-kinase activity\" EXACT []",
                "\"inositol-trisphosphate 5-kinase activity\" BROAD []",
                "\"ins(1,3,4)P(3) 5-kinase activity\" RELATED []",
                "\"IP3 5-kinase activity\" BROAD []"
              ],
              "previous": [
                "\"1D-myo-inositol-trisphosphate 5-kinase activity\" BROAD []",
                "\"inositol 1,3,4-trisphosphate 5-kinase activity\" EXACT []",
                "\"inositol-trisphosphate 5-kinase activity\" BROAD []",
                "\"ins(1,3,4)P(3) 5-kinase activity\" RELATED [EC:2.7.1.127]",
                "\"IP3 5-kinase activity\" BROAD [EC:2.7.1.127]"
              ]
            }
          }
        },
        {
          "id": "GO:0052822",
          "name": "DNA-3-methylguanine glycosylase activity",
          "changes": {
            "synonyms": {
              "current": "N/A",
              "previous": [
                "\"3-methylguanine DNA glycosylase I\" RELATED [EC:3.2.2.20]",
                "\"alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)\" BROAD [EC:3.2.2.20]",
                "\"deoxyribonucleate 3-methylguanine glycosidase I\" RELATED [EC:3.2.2.20]",
                "\"DNA glycosidase I activity\" RELATED [EC:3.2.2.20]"
              ]
            }
          }
        },
        {
          "id": "GO:0052839",
          "name": "diphosphoinositol tetrakisphosphate kinase activity",
          "changes": {
            "name": {
              "current": "diphosphoinositol tetrakisphosphate kinase activity",
              "previous": "inositol diphosphate tetrakisphosphate kinase activity"
            },
            "synonyms": {
              "current": [
                "\"inositol diphosphate tetrakisphosphate kinase activity\" EXACT []",
                "\"PP-IP4 kinase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052855",
          "name": "ADP-dependent NAD(P)H-hydrate dehydratase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)\" RELATED [EC:4.2.1.136]",
                "\"(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)\" RELATED [EC:4.2.1.136]",
                "\"ADP-dependent H(4)NAD(P)OH dehydratase activity\" EXACT []",
                "\"ADP-dependent H4NAD(P)OH dehydratase activity\" EXACT []"
              ],
              "previous": [
                "\"(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)\" RELATED [EC:4.2.1.136]",
                "\"(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)\" RELATED [EC:4.2.1.136]",
                "\"ADP-dependent H(4)NAD(P)OH dehydratase activity\" EXACT []",
                "\"ADP-dependent H4NAD(P)OH dehydratase activity\" EXACT []",
                "\"reduced nicotinamide adenine dinucleotide hydrate dehydratase activity\" BROAD [EC:4.2.1.93]"
              ]
            }
          }
        },
        {
          "id": "GO:0052861",
          "name": "endo-1,3(4)-beta-glucanase activity",
          "changes": {
            "name": {
              "current": "endo-1,3(4)-beta-glucanase activity",
              "previous": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group"
            },
            "definition": {
              "current": "\"Catalysis of the endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3. Substrates include laminarin, lichenin and cereal D-glucans.\" [EC:3.2.1.6]",
              "previous": "\"Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.\" [EC:3.2.1.6]"
            },
            "synonyms": {
              "current": [
                "\"1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity\" NARROW [EC:3.2.1.6]",
                "\"glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group\" NARROW []",
                "\"glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group\" NARROW []",
                "\"laminaranase activity\" RELATED [EC:3.2.1.6]",
                "\"laminarinase activity\" RELATED [EC:3.2.1.6]"
              ],
              "previous": [
                "\"1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity\" RELATED [EC:3.2.1.6]",
                "\"laminaranase activity\" RELATED [EC:3.2.1.6]",
                "\"laminarinase activity\" RELATED [EC:3.2.1.6]"
              ]
            }
          }
        },
        {
          "id": "GO:0052899",
          "name": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]",
                "\"polyamine oxidase activity\" BROAD [EC:1.5.3.13]"
              ],
              "previous": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]",
                "\"polyamine oxidase activity\" BROAD [EC:1.5.3.13, EC:1.5.3.17]"
              ]
            }
          }
        },
        {
          "id": "GO:0052903",
          "name": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]"
              ],
              "previous": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]",
                "\"non-specific polyamine oxidase activity\" BROAD [EC:1.5.3.17]",
                "\"polyamine oxidase activity\" BROAD [EC:1.5.3.13, EC:1.5.3.17]"
              ]
            }
          }
        },
        {
          "id": "GO:0052904",
          "name": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]"
              ],
              "previous": [
                "\"N(1)-acetylpolyamine oxidase activity\" BROAD [EC:1.5.3.13]",
                "\"non-specific polyamine oxidase activity\" BROAD [EC:1.5.3.17]",
                "\"polyamine oxidase activity\" BROAD [EC:1.5.3.13, EC:1.5.3.17]"
              ]
            }
          }
        },
        {
          "id": "GO:0060090",
          "name": "molecular adaptor activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"binding, bridging\" EXACT []",
                "\"protein complex scaffold activity\" BROAD []",
                "\"protein-containing complex scaffold activity\" BROAD []"
              ],
              "previous": [
                "\"binding, bridging\" EXACT []",
                "\"protein complex scaffold activity\" RELATED []",
                "\"protein-containing complex scaffold activity\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0062193",
          "name": "D-ribose pyranase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reactions",
              "previous": "\"Catalysis of the reaction"
            }
          }
        },
        {
          "id": "GO:0070204",
          "name": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this function was formerly EC:4.1.3.18."
            }
          }
        },
        {
          "id": "GO:0070330",
          "name": "aromatase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction",
              "previous": "\"Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.\" [GOC:cb]"
            }
          }
        },
        {
          "id": "GO:0070448",
          "name": "laricitrin 5'-O-methyltransferase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267."
            }
          }
        },
        {
          "id": "GO:0080098",
          "name": "L-tyrosine-pyruvate transaminase activity",
          "changes": {
            "name": {
              "current": "L-tyrosine-pyruvate transaminase activity",
              "previous": "L-tyrosine:pyruvate aminotransferase activity"
            },
            "synonyms": {
              "current": [
                "\"L-tyrosine aminotransferase activity\" BROAD []",
                "\"L-tyrosine:pyruvate aminotransferase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0080130",
          "name": "L-phenylalanine-2-oxoglutarate transaminase activity",
          "changes": {
            "name": {
              "current": "L-phenylalanine-2-oxoglutarate transaminase activity",
              "previous": "L-phenylalanine:2-oxoglutarate aminotransferase activity"
            },
            "comment": {
              "current": "N/A",
              "previous": "This reaction falls within the larger set of reactions associated with EC:2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57)."
            },
            "synonyms": {
              "current": [
                "\"L-phenylalanine:2-oxoglutarate aminotransferase activity\" EXACT []",
                "\"L-phenylalanine:alpha-ketoglutarate aminotransferase activity\" EXACT []"
              ],
              "previous": [
                "\"L-phenylalanine:alpha-ketoglutarate aminotransferase activity\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0080132",
          "name": "fatty acid 2-hydroxylase activity",
          "changes": {
            "name": {
              "current": "fatty acid 2-hydroxylase activity",
              "previous": "fatty acid alpha-hydroxylase activity"
            },
            "definition": {
              "current": "\"Catalysis of the hydroxylation of the C-2 position in a fatty acid. The 2-hydroxylation may occur on free fatty acids or within the fatty acyl chain of a sphingolipid.\" [PMID:36902339]",
              "previous": "\"Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain.\" [PMID:19054355]"
            },
            "synonyms": {
              "current": [
                "\"fatty acid alpha-hydroxylase activity\" EXACT []"
              ],
              "previous": [
                "\"fatty acid 2-hydroxylase\" EXACT []"
              ]
            }
          }
        },
        {
          "id": "GO:0102097",
          "name": "22alpha-hydroxysteroid 23-monooxygenase activity",
          "changes": {
            "name": {
              "current": "22alpha-hydroxysteroid 23-monooxygenase activity",
              "previous": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity"
            },
            "synonyms": {
              "current": [
                "\"(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102103",
          "name": "demethoxycurcumin synthase activity",
          "changes": {
            "name": {
              "current": "demethoxycurcumin synthase activity",
              "previous": "demethoxycurcumin synthase"
            }
          }
        },
        {
          "id": "GO:0102160",
          "name": "cyanidin 3-O-glucoside 2-O-glucuronosyltransferase activity",
          "changes": {
            "name": {
              "current": "cyanidin 3-O-glucoside 2-O-glucuronosyltransferase activity",
              "previous": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102238",
          "name": "ATP:geraniol kinase activity",
          "changes": {
            "name": {
              "current": "ATP:geraniol kinase activity",
              "previous": "geraniol kinase activity (ATP-dependent) activity"
            },
            "synonyms": {
              "current": [
                "\"geraniol kinase activity (ATP-dependent) activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102243",
          "name": "ATP:geranylgeraniol kinase activity",
          "changes": {
            "name": {
              "current": "ATP:geranylgeraniol kinase activity",
              "previous": "ATP:geranylgeraniol phosphotransferase activity"
            },
            "synonyms": {
              "current": [
                "\"ATP:geranylgeraniol phosphotransferase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102244",
          "name": "3-aminopropanal dehydrogenase (NAD+) activity",
          "changes": {
            "name": {
              "current": "3-aminopropanal dehydrogenase (NAD+) activity",
              "previous": "3-aminopropanal dehydrogenase activity"
            }
          }
        },
        {
          "id": "GO:0102261",
          "name": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"F420-dependent NADP reductase activity\" BROAD []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102307",
          "name": "erythromycin 3''-o-methyltransferase activity",
          "changes": {
            "name": {
              "current": "erythromycin 3''-o-methyltransferase activity",
              "previous": "erythromycin C 3''-o-methyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"erythromycin C 3''-o-methyltransferase activity\" NARROW []",
                "\"erythromycin D 3''-o-methyltransferase activity\" NARROW []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102365",
          "name": "taxoid 2alpha-hydroxylase activity",
          "changes": {
            "name": {
              "current": "taxoid 2alpha-hydroxylase activity",
              "previous": "taxusin 2-alpha-hydroxylase activity"
            },
            "synonyms": {
              "current": [
                "\"taxusin 2-alpha-hydroxylase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102457",
          "name": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) activity",
          "changes": {
            "name": {
              "current": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) activity",
              "previous": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity"
            },
            "synonyms": {
              "current": [
                "\"cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity\" RELATED []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102506",
          "name": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) activity",
          "changes": {
            "name": {
              "current": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) activity",
              "previous": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity"
            }
          }
        },
        {
          "id": "GO:0102561",
          "name": "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity",
          "changes": {
            "name": {
              "current": "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity",
              "previous": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity"
            },
            "synonyms": {
              "current": [
                "\"cyclic phosphate dihydrolase activity\" RELATED []",
                "\"D-ribose 2,5-bisphosphate 2-phosphohydrolase activity\" RELATED []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102672",
          "name": "fatty acid alpha-dioxygenase activity",
          "changes": {
            "name": {
              "current": "fatty acid alpha-dioxygenase activity",
              "previous": "fatty acid alpha-oxygenase activity"
            },
            "synonyms": {
              "current": [
                "\"fatty acid alpha-oxygenase activity\" BROAD []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102731",
          "name": "inositol-1,3,4,6-tetrakisphosphate 2-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,3,4,6-tetrakisphosphate 2-kinase activity",
              "previous": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102732",
          "name": "inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity",
          "changes": {
            "name": {
              "current": "inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity",
              "previous": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity"
            },
            "synonyms": {
              "current": [
                "\"1D-myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity\" EXACT []",
                "\"1D-myo-inositol-pentakisphosphate 5-kinase activity\" BROAD []",
                "\"inositol-pentakisphosphate 5-kinase activity\" BROAD []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102741",
          "name": "caffeine synthase activity",
          "changes": {
            "name": {
              "current": "caffeine synthase activity",
              "previous": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"3N-methyltransferase activity\" RELATED []",
                "\"dimethylxanthine methyltransferase activity\" RELATED []",
                "\"paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity\" NARROW []",
                "\"theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity\" NARROW []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102771",
          "name": "dihydroceramide fatty acyl 2-hydroxylase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"plant sphingolipid fatty acid 2-hydroxylase actitivy\" EXACT [EC:1.14.18.7]",
                "\"sphingolipid very long chain fatty acid alpha-hydroxylase activity\" RELATED []"
              ],
              "previous": [
                "\"sphingolipid very long chain fatty acid alpha-hydroxylase activity\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0102890",
          "name": "chalcone 4'-O-glucosyltransferase activity",
          "changes": {
            "name": {
              "current": "chalcone 4'-O-glucosyltransferase activity",
              "previous": "naringenin chalcone 4'-O-glucosyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"naringenin chalcone 4'-O-glucosyltransferase activity\" NARROW []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102917",
          "name": "(R,S)-reticuline 7-O-methyltransferase activity",
          "changes": {
            "name": {
              "current": "(R,S)-reticuline 7-O-methyltransferase activity",
              "previous": "(S)-reticuline 7-O-methyltransferase activity"
            },
            "synonyms": {
              "current": [
                "\"(R)-reticuline 7-O-methyltransferase activity\" EXACT []",
                "\"(S)-reticuline 7-O-methyltransferase activity\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0103043",
          "name": "phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity",
          "changes": {
            "name": {
              "current": "phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity",
              "previous": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity"
            },
            "synonyms": {
              "current": [
                "\"5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity\" RELATED []"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0106009",
          "name": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity",
          "changes": {
            "definition": {
              "current": "\"Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Specific for the (4S) enantiomer of 4-hydroxy-2-oxoglutarate.\" [PMID:1098660, PMID:1339418, RHEA:35639]",
              "previous": "\"Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.\" [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418]"
            }
          }
        },
        {
          "id": "GO:0106223",
          "name": "germacrene A hydroxylase activity",
          "changes": {
            "comment": {
              "current": "N/A",
              "previous": "Formerly EC:1.1.1.314."
            }
          }
        },
        {
          "id": "GO:0106407",
          "name": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"glucosidase II\" BROAD []"
              ],
              "previous": [
                "\"Glucosidase II\" BROAD []"
              ]
            }
          }
        },
        {
          "id": "GO:0106438",
          "name": "protein-glutamic acid ligase activity, elongating",
          "changes": {
            "definition": {
              "current": "\"Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate.\" [PMID:32747782, RHEA:60148]",
              "previous": "\"Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate.\" [PMID:32747782, Rhea:60148]"
            }
          }
        },
        {
          "id": "GO:0140803",
          "name": "NAD+-protein-cysteine ADP-ribosyltransferase activity",
          "changes": {
            "name": {
              "current": "NAD+-protein-cysteine ADP-ribosyltransferase activity",
              "previous": "NAD+- protein-cysteine ADP-ribosyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0140804",
          "name": "NAD+-protein-lysine ADP-ribosyltransferase activity",
          "changes": {
            "name": {
              "current": "NAD+-protein-lysine ADP-ribosyltransferase activity",
              "previous": "NAD+- protein-lysine ADP-ribosyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0140806",
          "name": "NAD+-protein-aspartate ADP-ribosyltransferase activity",
          "changes": {
            "name": {
              "current": "NAD+-protein-aspartate ADP-ribosyltransferase activity",
              "previous": "NAD+- protein-aspartate ADP-ribosyltransferase activity"
            }
          }
        },
        {
          "id": "GO:0160183",
          "name": "autophagosome-membrane adaptor activity",
          "changes": {
            "definition": {
              "current": "\"The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy.\" [PMID:30544615, PMID:36635405]",
              "previous": "\"The binding activity of a molecule that brings together a target membrane and an autophagosome during mitophagy.\" [PMID:30544615, PMID:36635405]"
            }
          }
        },
        {
          "id": "GO:1990404",
          "name": "NAD+-protein ADP-ribosyltransferase activity",
          "changes": {
            "synonyms": {
              "current": [
                "\"NAD+ ADP-ribosyltransferase activity\" BROAD []",
                "\"protein ADP-ribosylase activity\" EXACT []",
                "\"protein ADP-ribosyltransferase activity\" BROAD []",
                "\"ribosylase activity\" BROAD []"
              ],
              "previous": [
                "\"protein ADP-ribosylase activity\" EXACT []",
                "\"protein ADP-ribosyltransferase activity\" BROAD []",
                "\"ribosylase activity\" BROAD []"
              ]
            }
          }
        }
      ],
      "cellular_component": [
        {
          "id": "GO:0009390",
          "name": "dimethyl sulfoxide reductase complex",
          "changes": {
            "definition": {
              "current": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [UM-BBD_enzymeID:r0207]",
              "previous": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [UM-BBD_enzymeID:e0188]"
            }
          }
        },
        {
          "id": "GO:0019028",
          "name": "viral capsid",
          "changes": {
            "subsets": {
              "current": [
                "goslim_chembl",
                "goslim_virus"
              ],
              "previous": [
                "goslim_chembl"
              ]
            }
          }
        },
        {
          "id": "GO:0020002",
          "name": "host cell plasma membrane",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0020003",
          "name": "symbiont-containing vacuole",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0030964",
          "name": "NADH dehydrogenase complex",
          "changes": {
            "synonyms": {
              "current": [
                "\"NADH dehydrogenase complex (plastoquinone)\" NARROW []",
                "\"NADH dehydrogenase complex (quinone)\" NARROW []",
                "\"NADH dehydrogenase complex (ubiquinone)\" NARROW []",
                "\"NADH:plastoquinone reductase complex\" NARROW []",
                "\"plastid NADH dehydrogenase complex (plastoquinone)\" NARROW []"
              ],
              "previous": [
                "\"Complex I\" EXACT []",
                "\"NADH dehydrogenase complex (plastoquinone)\" NARROW []",
                "\"NADH dehydrogenase complex (quinone)\" NARROW []",
                "\"NADH dehydrogenase complex (ubiquinone)\" NARROW []",
                "\"NADH:plastoquinone reductase complex\" NARROW []",
                "\"plastid NADH dehydrogenase complex (plastoquinone)\" NARROW []"
              ]
            }
          }
        },
        {
          "id": "GO:0035098",
          "name": "ESC/E(Z) complex",
          "changes": {
            "definition": {
              "current": "\"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.\" [GOC:bf, GOC:krc, GOC:sp, PMID:12408863, PMID:12408864, PMID:17107999, PMID:20064375, PMID:31123059, PMID:33232890]",
              "previous": "\"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.\" [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]"
            },
            "synonyms": {
              "current": [
                "\"Extra Sex Combs/Enhancer of Zeste complex\" EXACT []",
                "\"polycomb repressive complex 2\" EXACT []",
                "\"PRC2 complex\" EXACT [GOC:sp, PMID:20064375]"
              ],
              "previous": [
                "\"Extra Sex Combs/Enhancer of Zeste complex\" EXACT []",
                "\"PRC2 complex\" EXACT [GOC:sp, PMID:20064375]"
              ]
            }
          }
        },
        {
          "id": "GO:0042025",
          "name": "host cell nucleus",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0043227",
          "name": "membrane-bounded organelle",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0043228",
          "name": "non-membrane-bounded organelle",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "goslim_mouse"
              ],
              "previous": [
                "goslim_mouse"
              ]
            }
          }
        },
        {
          "id": "GO:0043229",
          "name": "intracellular organelle",
          "changes": {
            "subsets": {
              "current": [
                "gocheck_do_not_annotate",
                "goslim_pir"
              ],
              "previous": [
                "goslim_pir"
              ]
            }
          }
        },
        {
          "id": "GO:0044161",
          "name": "host cell cytoplasmic vesicle",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0044165",
          "name": "host cell endoplasmic reticulum",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0044177",
          "name": "host cell Golgi apparatus",
          "changes": {
            "subsets": {
              "current": [
                "goslim_virus"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0097545",
          "name": "axonemal doublet microtubule",
          "changes": {
            "name": {
              "current": "axonemal doublet microtubule",
              "previous": "axonemal outer doublet"
            },
            "definition": {
              "current": "\"A cellular anatomical entity that is part of an axoneme consisting of a doublet microtubule.\" [GOC:cilia, GOC:krc, GOC:pr, https://github.com/geneontology/go-ontology/issues/26128, PMID:5044758, PMID:5664206, Wikipedia:Axoneme]",
              "previous": "\"Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium.\" [GOC:cilia, GOC:krc, GOC:pr, PMID:5044758, PMID:5664206, Wikipedia:Axoneme]"
            },
            "synonyms": {
              "current": [
                "\"axonemal outer doublet\" EXACT []",
                "\"axoneme outer doublet\" EXACT []",
                "\"DMT\" RELATED []",
                "\"outer doublet\" BROAD []",
                "\"outer-doublet microtubules\" RELATED []"
              ],
              "previous": [
                "\"axoneme outer doublet\" EXACT []",
                "\"outer doublet\" BROAD []",
                "\"outer-doublet microtubules\" RELATED []"
              ]
            }
          }
        },
        {
          "id": "GO:0098803",
          "name": "respiratory chain complex",
          "changes": {
            "synonyms": {
              "current": [
                "\"respirasome\" EXACT []"
              ],
              "previous": "N/A"
            }
          }
        }
      ]
    },
    "cross_references": {
      "molecular_function": [
        {
          "id": "GO:0000121",
          "name": "glycerol-1-phosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.3.21",
                "MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN",
                "RHEA:46084"
              ],
              "previous": [
                "EC:3.1.3.21",
                "MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN",
                "RHEA:11476"
              ]
            }
          }
        },
        {
          "id": "GO:0000234",
          "name": "phosphoethanolamine N-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.103",
                "KEGG_REACTION:R02037",
                "KEGG_REACTION:R06868"
              ],
              "previous": [
                "EC:2.1.1.103",
                "KEGG_REACTION:R02037",
                "MetaCyc:2.1.1.103-RXN",
                "RHEA:20365"
              ]
            }
          }
        },
        {
          "id": "GO:0000247",
          "name": "C-8 sterol isomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN3O-203",
                "RHEA:33435"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0000249",
          "name": "C-22 sterol desaturase (NADPH) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.19.41",
                "MetaCyc:RXN3O-227"
              ],
              "previous": [
                "EC:1.14.19.41 {comment=\"skos:exactMatch\"}",
                "MetaCyc:RXN3O-227"
              ]
            }
          }
        },
        {
          "id": "GO:0000257",
          "name": "nitrilase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.5.1",
                "KEGG_REACTION:R00540",
                "MetaCyc:3.5.5.1-RXN",
                "RHEA:21724",
                "UM-BBD_reactionID:r0377",
                "UM-BBD_reactionID:r0701"
              ],
              "previous": [
                "EC:3.5.5.1",
                "KEGG_REACTION:R00540",
                "MetaCyc:3.5.5.1-RXN",
                "RHEA:21724",
                "UM-BBD_enzymeID:e0283"
              ]
            }
          }
        },
        {
          "id": "GO:0000773",
          "name": "phosphatidyl-N-methylethanolamine N-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.71",
                "MetaCyc:2.1.1.71-RXN"
              ],
              "previous": [
                "EC:2.1.1.71",
                "MetaCyc:2.1.1.71-RXN",
                "RHEA:32735"
              ]
            }
          }
        },
        {
          "id": "GO:0000823",
          "name": "inositol-1,4,5-trisphosphate 6-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.151",
                "KEGG_REACTION:R05800",
                "MetaCyc:2.7.1.151-RXN",
                "RHEA:17717"
              ],
              "previous": [
                "EC:2.7.1.151",
                "KEGG_REACTION:R05800",
                "MetaCyc:2.7.1.151-RXN",
                "RHEA:32359"
              ]
            }
          }
        },
        {
          "id": "GO:0000824",
          "name": "inositol-1,4,5,6-tetrakisphosphate 3-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.151",
                "KEGG_REACTION:R05801",
                "MetaCyc:RXN-7162",
                "Reactome:R-HSA-1855185 \"I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\"",
                "RHEA:11856"
              ],
              "previous": [
                "Reactome:R-HSA-1855185 \"I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\"",
                "RHEA:11856"
              ]
            }
          }
        },
        {
          "id": "GO:0000825",
          "name": "inositol-1,3,4,5-tetrakisphosphate 6-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.151",
                "KEGG_REACTION:R10953",
                "MetaCyc:RXN-7184",
                "Reactome:R-HSA-1855206 \"I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\""
              ],
              "previous": [
                "MetaCyc:RXN-7184",
                "Reactome:R-HSA-1855206 \"I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\""
              ]
            }
          }
        },
        {
          "id": "GO:0000827",
          "name": "inositol-1,3,4,5,6-pentakisphosphate kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-1855181 \"I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus\"",
                "Reactome:R-HSA-1855223 \"I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol\""
              ],
              "previous": [
                "EC:2.7.4.21",
                "Reactome:R-HSA-1855181 \"I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus\"",
                "Reactome:R-HSA-1855223 \"I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol\""
              ]
            }
          }
        },
        {
          "id": "GO:0002952",
          "name": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.3.1.32",
                "MetaCyc:RXN-15216",
                "RHEA:44360"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0003844",
          "name": "1,4-alpha-glucan branching enzyme activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.18",
                "MetaCyc:GLYCOGEN-BRANCH-RXN",
                "MetaCyc:RXN-7669",
                "Reactome:R-HSA-3322005 \"GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a\"",
                "Reactome:R-HSA-3322016 \"GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a\"",
                "Reactome:R-HSA-3322057 \"GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b\"",
                "Reactome:R-HSA-3878762 \"Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)\""
              ],
              "previous": [
                "EC:2.4.1.18",
                "MetaCyc:GLYCOGEN-BRANCH-RXN",
                "Reactome:R-HSA-3322005 \"GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a\"",
                "Reactome:R-HSA-3322016 \"GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a\"",
                "Reactome:R-HSA-3322057 \"GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b\"",
                "Reactome:R-HSA-3878762 \"Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)\""
              ]
            }
          }
        },
        {
          "id": "GO:0003845",
          "name": "11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-194023 \"HSD11B2,HSD11B1 dimer oxidise CORT to COR\"",
                "Wikipedia:11beta-hydroxysteroid_dehydrogenase"
              ],
              "previous": [
                "MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN",
                "Reactome:R-HSA-194023 \"HSD11B2,HSD11B1 dimer oxidise CORT to COR\"",
                "Wikipedia:11beta-hydroxysteroid_dehydrogenase"
              ]
            }
          }
        },
        {
          "id": "GO:0003853",
          "name": "short-chain 2-methyl fatty acyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.8.5",
                "KEGG_REACTION:R03169"
              ],
              "previous": [
                "EC:1.3.8.5",
                "KEGG_REACTION:R03169",
                "MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN",
                "RHEA:43780"
              ]
            }
          }
        },
        {
          "id": "GO:0003857",
          "name": "3-hydroxyacyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.35",
                "MetaCyc:OHACYL-COA-DEHYDROG-RXN",
                "Reactome:R-HSA-193455 \"(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA\"",
                "Reactome:R-HSA-193508 \"(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA\"",
                "Reactome:R-HSA-389995 \"3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+\"",
                "Reactome:R-HSA-390251 \"HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA\"",
                "Reactome:R-HSA-508369 \"alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+\"",
                "Reactome:R-HSA-6809264 \"EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA\"",
                "Reactome:R-HSA-70837 \"alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+\"",
                "Reactome:R-HSA-77254 \"(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77283 \"(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77303 \"(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77312 \"(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77323 \"(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77331 \"(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77342 \"(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H\"",
                "RHEA:22432",
                "UM-BBD_reactionID:r1063"
              ],
              "previous": [
                "EC:1.1.1.35",
                "MetaCyc:OHACYL-COA-DEHYDROG-RXN",
                "Reactome:R-HSA-193455 \"(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA\"",
                "Reactome:R-HSA-193508 \"(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA\"",
                "Reactome:R-HSA-389995 \"3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+\"",
                "Reactome:R-HSA-390251 \"HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA\"",
                "Reactome:R-HSA-508369 \"alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+\"",
                "Reactome:R-HSA-6809264 \"EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA\"",
                "Reactome:R-HSA-70837 \"alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+\"",
                "Reactome:R-HSA-77254 \"(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77283 \"(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77303 \"(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77312 \"(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77323 \"(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77331 \"(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H\"",
                "Reactome:R-HSA-77342 \"(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H\"",
                "RHEA:22432",
                "UM-BBD_enzymeID:e0664"
              ]
            }
          }
        },
        {
          "id": "GO:0003865",
          "name": "3-oxo-5-alpha-steroid 4-dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.99.5",
                "MetaCyc:RXN-13682",
                "Reactome:R-HSA-469659 \"SRD5A1 dehydrogenates TEST to DHTEST\"",
                "Reactome:R-HSA-9705713 \"SRD5A2 dehydrogenates TEST to DHTEST\"",
                "Reactome:R-HSA-9705714 \"SRD5A3 dehydrogenates TEST to DHTEST\"",
                "RHEA:13805"
              ],
              "previous": [
                "EC:1.3.99.5",
                "MetaCyc:1.3.99.5-RXN",
                "Reactome:R-HSA-469659 \"SRD5A1 dehydrogenates TEST to DHTEST\"",
                "Reactome:R-HSA-9705713 \"SRD5A2 dehydrogenates TEST to DHTEST\"",
                "Reactome:R-HSA-9705714 \"SRD5A3 dehydrogenates TEST to DHTEST\"",
                "RHEA:13805"
              ]
            }
          }
        },
        {
          "id": "GO:0003867",
          "name": "4-aminobutyrate transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-916855 \"PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA\""
              ],
              "previous": [
                "MetaCyc:GABATRANSAM-RXN",
                "Reactome:R-HSA-916855 \"PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA\"",
                "RHEA:23352"
              ]
            }
          }
        },
        {
          "id": "GO:0003875",
          "name": "ADP-ribosylarginine hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.2.19"
              ],
              "previous": [
                "EC:3.2.2.19",
                "MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN",
                "RHEA:20784"
              ]
            }
          }
        },
        {
          "id": "GO:0003904",
          "name": "deoxyribodipyrimidine photo-lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.99.3",
                "RHEA:10672"
              ],
              "previous": [
                "EC:4.1.99.3",
                "MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN",
                "RHEA:10672"
              ]
            }
          }
        },
        {
          "id": "GO:0003913",
          "name": "DNA photolyase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0003959",
          "name": "NADPH dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.6.99.1",
                "MetaCyc:NADPH-DEHYDROGENASE-RXN",
                "Reactome:R-HSA-9018867 \"5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2\"",
                "Reactome:R-HSA-9018901 \"5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2\"",
                "Reactome:R-HSA-9027625 \"5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3\"",
                "Reactome:R-HSA-9027631 \"5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA\"",
                "Reactome:R-HSA-9027632 \"5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA\"",
                "RHEA:13149"
              ],
              "previous": [
                "EC:1.6.99.1",
                "MetaCyc:NADPH-DEHYDROGENASE-RXN",
                "Reactome:R-HSA-9018867 \"5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2\"",
                "Reactome:R-HSA-9018901 \"5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2\"",
                "Reactome:R-HSA-9027625 \"5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3\"",
                "Reactome:R-HSA-9027631 \"5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA\"",
                "Reactome:R-HSA-9027632 \"5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA\"",
                "RHEA:13149",
                "UM-BBD_enzymeID:e0523"
              ]
            }
          }
        },
        {
          "id": "GO:0003985",
          "name": "acetyl-CoA C-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.9",
                "MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN",
                "Reactome:R-HSA-70844 \"alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA\"",
                "Reactome:R-HSA-73916 \"2 acetyl-CoA <=> acetoacetyl-CoA + CoA\"",
                "Reactome:R-HSA-74181 \"acetoacetyl-CoA + CoA <=> 2 acetyl-CoA\"",
                "Reactome:R-HSA-8848215 \"ACAT2 condenses 2 Ac-CoA to form ACA-CoA\"",
                "RHEA:21036",
                "UM-BBD_reactionID:r0201"
              ],
              "previous": [
                "EC:2.3.1.9",
                "MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN",
                "Reactome:R-HSA-70844 \"alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA\"",
                "Reactome:R-HSA-73916 \"2 acetyl-CoA <=> acetoacetyl-CoA + CoA\"",
                "Reactome:R-HSA-74181 \"acetoacetyl-CoA + CoA <=> 2 acetyl-CoA\"",
                "Reactome:R-HSA-8848215 \"ACAT2 condenses 2 Ac-CoA to form ACA-CoA\"",
                "RHEA:21036",
                "UM-BBD_enzymeID:e0144"
              ]
            }
          }
        },
        {
          "id": "GO:0004022",
          "name": "alcohol dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.1",
                "MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN",
                "Reactome:R-HSA-2162078 \"abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+\"",
                "Reactome:R-HSA-71707 \"ethanol + NAD+ => acetaldehyde + NADH + H+\"",
                "RHEA:10740",
                "UM-BBD_reactionID:r0022",
                "UM-BBD_reactionID:r0603"
              ],
              "previous": [
                "EC:1.1.1.1",
                "MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN",
                "Reactome:R-HSA-2162078 \"abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+\"",
                "RHEA:10740",
                "UM-BBD_enzymeID:e0023"
              ]
            }
          }
        },
        {
          "id": "GO:0004028",
          "name": "3-chloroallyl aldehyde dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "UM-BBD_enzymeID:e0432"
              ]
            }
          }
        },
        {
          "id": "GO:0004029",
          "name": "aldehyde dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.2.1.3",
                "MetaCyc:ALDHDEHYDROG-RXN",
                "Reactome:R-HSA-380608 \"5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid\"",
                "Reactome:R-HSA-389609 \"ALDH3A2-2 oxidizes pristanal to pristanate\"",
                "Reactome:R-HSA-5692261 \"ALDH3A2-1 oxidises HD2NAL to PALM\"",
                "Reactome:R-HSA-5696091 \"ALDH1B1 tetramer oxidises CH3CHO to CH3COOH\"",
                "Reactome:R-HSA-6808487 \"ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG\"",
                "Reactome:R-HSA-6808496 \"ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG\"",
                "Reactome:R-HSA-6813749 \"ALDH1A1 oxidises GA to DGA\"",
                "Reactome:R-HSA-71691 \"acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]\"",
                "Reactome:R-HSA-71723 \"acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]\"",
                "RHEA:16185",
                "UM-BBD_reactionID:r0003",
                "UM-BBD_reactionID:r0023",
                "UM-BBD_reactionID:r0605",
                "Wikipedia:Aldehyde_dehydrogenase_(NAD+)"
              ],
              "previous": [
                "EC:1.2.1.3",
                "MetaCyc:ALDHDEHYDROG-RXN",
                "Reactome:R-HSA-380608 \"5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid\"",
                "Reactome:R-HSA-389609 \"ALDH3A2-2 oxidizes pristanal to pristanate\"",
                "Reactome:R-HSA-5692261 \"ALDH3A2-1 oxidises HD2NAL to PALM\"",
                "Reactome:R-HSA-5696091 \"ALDH1B1 tetramer oxidises CH3CHO to CH3COOH\"",
                "Reactome:R-HSA-6808487 \"ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG\"",
                "Reactome:R-HSA-6808496 \"ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG\"",
                "Reactome:R-HSA-6813749 \"ALDH1A1 oxidises GA to DGA\"",
                "Reactome:R-HSA-71691 \"acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]\"",
                "Reactome:R-HSA-71723 \"acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]\"",
                "RHEA:16185",
                "UM-BBD_enzymeID:e0024",
                "Wikipedia:Aldehyde_dehydrogenase_(NAD+)"
              ]
            }
          }
        },
        {
          "id": "GO:0004030",
          "name": "aldehyde dehydrogenase [NAD(P)+] activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.2.1.5",
                "MetaCyc:ALDEHYDE-DEHYDROGENASE-NADORNOP+-RXN",
                "Reactome:R-HSA-5692283 \"ALD3A1 oxidises 4HPCP to CXPA\"",
                "Reactome:R-HSA-5696080 \"ALDH3B1 oxidises HXAL to PALM\"",
                "Reactome:R-HSA-6808464 \"ALDH3B2 oxidises HXAL to PALM\""
              ],
              "previous": [
                "EC:1.2.1.5",
                "MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN",
                "Reactome:R-HSA-5692283 \"ALD3A1 oxidises 4HPCP to CXPA\"",
                "Reactome:R-HSA-5696080 \"ALDH3B1 oxidises HXAL to PALM\"",
                "Reactome:R-HSA-6808464 \"ALDH3B2 oxidises HXAL to PALM\""
              ]
            }
          }
        },
        {
          "id": "GO:0004034",
          "name": "aldose 1-epimerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.1.3.3",
                "MetaCyc:ALDOSE-1-EPIMERASE-RXN"
              ],
              "previous": [
                "EC:5.1.3.3",
                "MetaCyc:ALDOSE-1-EPIMERASE-RXN",
                "RHEA:10264"
              ]
            }
          }
        },
        {
          "id": "GO:0004040",
          "name": "amidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.1.4",
                "MetaCyc:AMIDASE-RXN",
                "RHEA:12020",
                "UM-BBD_reactionID:r0084",
                "UM-BBD_reactionID:r0375",
                "UM-BBD_reactionID:r1440"
              ],
              "previous": [
                "EC:3.5.1.4",
                "MetaCyc:AMIDASE-RXN",
                "RHEA:12020",
                "UM-BBD_enzymeID:e0068"
              ]
            }
          }
        },
        {
          "id": "GO:0004050",
          "name": "apyrase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.6.1.5",
                "MetaCyc:RXN-14024",
                "RHEA:36795"
              ],
              "previous": [
                "EC:3.6.1.5",
                "MetaCyc:APYRASE-RXN",
                "RHEA:36795"
              ]
            }
          }
        },
        {
          "id": "GO:0004051",
          "name": "arachidonate 5-lipoxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.34",
                "Reactome:R-HSA-265296 \"Arachidonic acid is oxidised to 5S-HpETE by ALOX5\"",
                "Reactome:R-HSA-266051 \"5S-HpETE is dehydrated to LTA4 by ALOX5\"",
                "Reactome:R-HSA-9018858 \"ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE\"",
                "Reactome:R-HSA-9018859 \"ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE\"",
                "Reactome:R-HSA-9018863 \"ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE\"",
                "Reactome:R-HSA-9018894 \"ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE\"",
                "Reactome:R-HSA-9020251 \"ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA\"",
                "Reactome:R-HSA-9020255 \"ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA\"",
                "Reactome:R-HSA-9020256 \"ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA\"",
                "Reactome:R-HSA-9020259 \"ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA\"",
                "Reactome:R-HSA-9020264 \"ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA\"",
                "Reactome:R-HSA-9020277 \"ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA\"",
                "Reactome:R-HSA-9020278 \"ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA\"",
                "Reactome:R-HSA-9020282 \"ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA\"",
                "Reactome:R-HSA-9024997 \"ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA\"",
                "Reactome:R-HSA-9025995 \"ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3\"",
                "Reactome:R-HSA-9025996 \"ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3\"",
                "Reactome:R-HSA-9025999 \"ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3\"",
                "Reactome:R-HSA-9026005 \"ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA\"",
                "Reactome:R-HSA-9026405 \"ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4\"",
                "Reactome:R-HSA-9027624 \"ALOX5 oxidises DHA to 7-HDHA\"",
                "Reactome:R-HSA-9027628 \"ALOX5 oxidises EPA to 5-HEPE\"",
                "Reactome:R-HSA-9027633 \"ALOX5 oxidises DPAn-3 to 7-HDPAn-3\"",
                "RHEA:32307"
              ],
              "previous": [
                "EC:1.13.11.34",
                "MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN",
                "Reactome:R-HSA-265296 \"Arachidonic acid is oxidised to 5S-HpETE by ALOX5\"",
                "Reactome:R-HSA-266051 \"5S-HpETE is dehydrated to LTA4 by ALOX5\"",
                "Reactome:R-HSA-9018858 \"ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE\"",
                "Reactome:R-HSA-9018859 \"ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE\"",
                "Reactome:R-HSA-9018863 \"ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE\"",
                "Reactome:R-HSA-9018894 \"ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE\"",
                "Reactome:R-HSA-9020251 \"ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA\"",
                "Reactome:R-HSA-9020255 \"ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA\"",
                "Reactome:R-HSA-9020256 \"ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA\"",
                "Reactome:R-HSA-9020259 \"ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA\"",
                "Reactome:R-HSA-9020264 \"ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA\"",
                "Reactome:R-HSA-9020277 \"ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA\"",
                "Reactome:R-HSA-9020278 \"ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA\"",
                "Reactome:R-HSA-9020282 \"ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA\"",
                "Reactome:R-HSA-9024997 \"ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA\"",
                "Reactome:R-HSA-9025995 \"ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3\"",
                "Reactome:R-HSA-9025996 \"ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3\"",
                "Reactome:R-HSA-9025999 \"ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3\"",
                "Reactome:R-HSA-9026005 \"ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA\"",
                "Reactome:R-HSA-9026405 \"ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4\"",
                "Reactome:R-HSA-9027624 \"ALOX5 oxidises DHA to 7-HDHA\"",
                "Reactome:R-HSA-9027628 \"ALOX5 oxidises EPA to 5-HEPE\"",
                "Reactome:R-HSA-9027633 \"ALOX5 oxidises DPAn-3 to 7-HDPAn-3\"",
                "RHEA:32307"
              ]
            }
          }
        },
        {
          "id": "GO:0004060",
          "name": "arylamine N-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.5",
                "MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN",
                "Reactome:R-HSA-174963 \"NAT1 acetylation\"",
                "Reactome:R-HSA-174967 \"NAT2 acetylation\"",
                "Reactome:R-HSA-9753676 \"NAT1,2 acetylate APAP-Cys to APAP-Mer\"",
                "RHEA:16613",
                "UM-BBD_reactionID:r1333",
                "UM-BBD_reactionID:r1626"
              ],
              "previous": [
                "EC:2.3.1.5",
                "MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN",
                "Reactome:R-HSA-174963 \"NAT1 acetylation\"",
                "Reactome:R-HSA-174967 \"NAT2 acetylation\"",
                "Reactome:R-HSA-9753676 \"NAT1,2 acetylate APAP-Cys to APAP-Mer\"",
                "RHEA:16613",
                "UM-BBD_enzymeID:e0341"
              ]
            }
          }
        },
        {
          "id": "GO:0004063",
          "name": "aryldialkylphosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.8.1",
                "MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN",
                "RHEA:18053",
                "UM-BBD_enzymeID:r0067",
                "UM-BBD_reactionID:r0064"
              ],
              "previous": [
                "EC:3.1.8.1",
                "MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN",
                "RHEA:18053",
                "UM-BBD_enzymeID:e0054"
              ]
            }
          }
        },
        {
          "id": "GO:0004077",
          "name": "biotin--[biotin carboxyl-carrier protein] ligase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.3.4.15",
                "MetaCyc:BIOTINLIG-RXN",
                "Reactome:R-HSA-2993447 \"HLCS biotinylates 6x(PCCA:PCCB)\"",
                "Reactome:R-HSA-2993799 \"HLCS biotinylates 6xMCCC1:6xMCCC2\"",
                "Reactome:R-HSA-2993802 \"HLCS biotinylates PC:Mn2+\"",
                "Reactome:R-HSA-2993814 \"HLCS biotinylates ACACA:Mn2+\"",
                "Reactome:R-HSA-3323184 \"Defective HLCS does not biotinylate ACACA:Mn2+\"",
                "Reactome:R-HSA-4167511 \"HLCS biotinylates ACACB\"",
                "Reactome:R-HSA-9035987 \"Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2\"",
                "Reactome:R-HSA-9035988 \"Defective HLCS does not biotinylate PC:Mn2+\"",
                "Reactome:R-HSA-9035990 \"Defective HLCS does not biotinylate 6x(PCCA:PCCB)\"",
                "RHEA:11756"
              ],
              "previous": [
                "EC:6.3.4.15",
                "MetaCyc:BIOTINLIG-RXN",
                "RHEA:11756"
              ]
            }
          }
        },
        {
          "id": "GO:0004096",
          "name": "catalase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.11.1.6",
                "MetaCyc:CATAL-RXN",
                "Reactome:R-HSA-1222704 \"KatG reduces H2O2\"",
                "Reactome:R-HSA-76031 \"2 H2O2 => O2 + 2 H2O\"",
                "RHEA:20309",
                "UM-BBD_enzymeID:r1335"
              ],
              "previous": [
                "EC:1.11.1.6",
                "MetaCyc:CATAL-RXN",
                "Reactome:R-HSA-1222704 \"KatG reduces H2O2\"",
                "Reactome:R-HSA-76031 \"2 H2O2 => O2 + 2 H2O\"",
                "RHEA:20309",
                "UM-BBD_enzymeID:e0834"
              ]
            }
          }
        },
        {
          "id": "GO:0004108",
          "name": "citrate (Si)-synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.3.1",
                "Reactome:R-HSA-70975 \"Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA\""
              ],
              "previous": [
                "EC:2.3.3.1",
                "MetaCyc:CITSYN-RXN",
                "Reactome:R-HSA-70975 \"Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA\""
              ]
            }
          }
        },
        {
          "id": "GO:0004126",
          "name": "cytidine deaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.4.5",
                "Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"",
                "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"",
                "Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine\""
              ],
              "previous": [
                "EC:3.5.4.14",
                "EC:3.5.4.5",
                "Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"",
                "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"",
                "Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine\""
              ]
            }
          }
        },
        {
          "id": "GO:0004300",
          "name": "enoyl-CoA hydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.17",
                "MetaCyc:ENOYL-COA-HYDRAT-RXN",
                "Reactome:R-HSA-70830 \"tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA\"",
                "Reactome:R-HSA-70870 \"ECHS1 hydrates methacrylyl-CoA\"",
                "Reactome:R-HSA-77256 \"2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA\"",
                "Reactome:R-HSA-77277 \"trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA\"",
                "Reactome:R-HSA-77301 \"trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA\"",
                "Reactome:R-HSA-77314 \"Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA\"",
                "Reactome:R-HSA-77325 \"trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA\"",
                "Reactome:R-HSA-77333 \"trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA\"",
                "Reactome:R-HSA-77344 \"trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA\""
              ],
              "previous": [
                "EC:4.2.1.17",
                "MetaCyc:ENOYL-COA-HYDRAT-RXN",
                "Reactome:R-HSA-70830 \"tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA\"",
                "Reactome:R-HSA-70870 \"ECHS1 hydrates methacrylyl-CoA\"",
                "Reactome:R-HSA-77256 \"2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA\"",
                "Reactome:R-HSA-77277 \"trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA\"",
                "Reactome:R-HSA-77301 \"trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA\"",
                "Reactome:R-HSA-77314 \"Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA\"",
                "Reactome:R-HSA-77325 \"trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA\"",
                "Reactome:R-HSA-77333 \"trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA\"",
                "Reactome:R-HSA-77344 \"trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA\"",
                "UM-BBD_enzymeID:e0014"
              ]
            }
          }
        },
        {
          "id": "GO:0004301",
          "name": "epoxide hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.3.2.10",
                "MetaCyc:3.3.2.10-RXN",
                "Reactome:R-HSA-2161961 \"EET(1) is hydrolysed to DHET(1) by EPHX2\"",
                "Reactome:R-HSA-9018862 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1\"",
                "Reactome:R-HSA-9018877 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1\"",
                "Reactome:R-HSA-9020252 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2\"",
                "Reactome:R-HSA-9020253 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4\"",
                "Reactome:R-HSA-9020257 \"LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1\"",
                "Reactome:R-HSA-9020258 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2\"",
                "Reactome:R-HSA-9020270 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4\"",
                "Reactome:R-HSA-9024890 \"LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1\"",
                "Reactome:R-HSA-9024973 \"Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1\"",
                "Reactome:R-HSA-9024993 \"EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2\"",
                "Reactome:R-HSA-9025998 \"Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA\"",
                "Reactome:R-HSA-9026000 \"Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA\"",
                "Reactome:R-HSA-9026008 \"Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA\"",
                "RHEA:19037"
              ],
              "previous": [
                "EC:3.3.2.10",
                "MetaCyc:3.3.2.10-RXN",
                "Reactome:R-HSA-2161961 \"EET(1) is hydrolysed to DHET(1) by EPHX2\"",
                "Reactome:R-HSA-9018862 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1\"",
                "Reactome:R-HSA-9018877 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1\"",
                "Reactome:R-HSA-9020252 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2\"",
                "Reactome:R-HSA-9020253 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4\"",
                "Reactome:R-HSA-9020257 \"LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1\"",
                "Reactome:R-HSA-9020258 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2\"",
                "Reactome:R-HSA-9020270 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4\"",
                "Reactome:R-HSA-9024890 \"LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1\"",
                "Reactome:R-HSA-9024973 \"Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1\"",
                "Reactome:R-HSA-9024993 \"EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2\"",
                "Reactome:R-HSA-9025998 \"Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA\"",
                "Reactome:R-HSA-9026000 \"Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA\"",
                "Reactome:R-HSA-9026008 \"Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA\"",
                "RHEA:19037",
                "UM-BBD_enzymeID:e0397"
              ]
            }
          }
        },
        {
          "id": "GO:0004467",
          "name": "long-chain fatty acid-CoA ligase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.2.1.3",
                "MetaCyc:PWY-5143",
                "MetaCyc:RXN-7904",
                "Reactome:R-HSA-159425 \"Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-192137 \"THCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193401 \"THCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193407 \"DHCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193424 \"DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193711 \"3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193727 \"TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193743 \"3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193766 \"TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-201035 \"ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA\"",
                "Reactome:R-HSA-2046085 \"Activation of alpha-linolenic acid to alpha-linolenoyl-CoA\"",
                "Reactome:R-HSA-2046098 \"Activation of linoleic acid to linoleoyl-CoA\"",
                "Reactome:R-HSA-548843 \"ACSL3,4 ligate CoA to AA to form AA-CoA\"",
                "Reactome:R-HSA-5696004 \"ACSF2 ligates CoA-SH to MCFA\"",
                "Reactome:R-HSA-9734535 \"SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA\"",
                "RHEA:15421"
              ],
              "previous": [
                "EC:6.2.1.3",
                "MetaCyc:PWY-5143",
                "MetaCyc:RXN-7904",
                "Reactome:R-HSA-159425 \"Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-192137 \"THCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193401 \"THCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193407 \"DHCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193424 \"DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193711 \"3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-193727 \"TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193743 \"3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)\"",
                "Reactome:R-HSA-193766 \"TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)\"",
                "Reactome:R-HSA-201035 \"ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA\"",
                "Reactome:R-HSA-2046085 \"Activation of alpha-linolenic acid to alpha-linolenoyl-CoA\"",
                "Reactome:R-HSA-2046098 \"Activation of linoleic acid to linoleoyl-CoA\"",
                "Reactome:R-HSA-548843 \"ACSL3,4 ligate CoA to AA to form AA-CoA\"",
                "Reactome:R-HSA-5696004 \"ACSF2 ligates CoA-SH to MCFA\"",
                "Reactome:R-HSA-9734535 \"SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA\"",
                "RHEA:15421",
                "UM-BBD_enzymeID:e0025"
              ]
            }
          }
        },
        {
          "id": "GO:0004486",
          "name": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-200644 \"5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+\"",
                "Reactome:R-HSA-200718 \"MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG\""
              ],
              "previous": [
                "EC:1.5.1.5",
                "Reactome:R-HSA-200644 \"5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+\"",
                "Reactome:R-HSA-200718 \"MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG\""
              ]
            }
          }
        },
        {
          "id": "GO:0004522",
          "name": "ribonuclease A activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.6.1.18",
                "Wikipedia:Ribonuclease_A"
              ],
              "previous": [
                "EC:4.6.1.18",
                "MetaCyc:3.1.27.5-RXN",
                "Wikipedia:Ribonuclease_A"
              ]
            }
          }
        },
        {
          "id": "GO:0004551",
          "name": "dinucleotide phosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-196955 \"2xENPP1 hydrolyzes FAD to FMN\""
              ],
              "previous": [
                "MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN",
                "Reactome:R-HSA-196955 \"2xENPP1 hydrolyzes FAD to FMN\""
              ]
            }
          }
        },
        {
          "id": "GO:0004574",
          "name": "oligo-1,6-glucosidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.1.10"
              ],
              "previous": [
                "EC:3.2.1.10",
                "MetaCyc:3.2.1.10-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0004596",
          "name": "peptide alpha-N-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.255",
                "Reactome:R-HSA-6814090 \"NatC acetylates ARFFRP1\"",
                "RHEA:21028"
              ],
              "previous": [
                "EC:2.3.1.255",
                "Reactome:R-HSA-6814090 \"NatC acetylates ARFFRP1\""
              ]
            }
          }
        },
        {
          "id": "GO:0004611",
          "name": "phosphoenolpyruvate carboxykinase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:4.1.1.32"
              ]
            }
          }
        },
        {
          "id": "GO:0004675",
          "name": "transmembrane receptor protein serine/threonine kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:2.7.11.30-RXN",
                "Reactome:R-HSA-170868 \"Activated type I receptor phosphorylates SMAD2/3 directly\"",
                "Reactome:R-HSA-198732 \"STAT3 activation\"",
                "Reactome:R-HSA-201476 \"Activated type I receptor phosphorylates R-Smad1/5/8 directly\"",
                "RHEA:18673"
              ],
              "previous": [
                "EC:2.7.11.30",
                "MetaCyc:2.7.11.30-RXN",
                "Reactome:R-HSA-170868 \"Activated type I receptor phosphorylates SMAD2/3 directly\"",
                "Reactome:R-HSA-198732 \"STAT3 activation\"",
                "Reactome:R-HSA-201476 \"Activated type I receptor phosphorylates R-Smad1/5/8 directly\"",
                "RHEA:18673"
              ]
            }
          }
        },
        {
          "id": "GO:0004764",
          "name": "shikimate 3-dehydrogenase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.25",
                "EC:1.1.1.282",
                "KEGG_REACTION:R02413",
                "MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN",
                "RHEA:17737"
              ],
              "previous": [
                "EC:1.1.1.25",
                "EC:1.1.1.282 {comment=\"skos:broadMatch\"}",
                "KEGG_REACTION:R02413",
                "MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN",
                "RHEA:17737"
              ]
            }
          }
        },
        {
          "id": "GO:0004806",
          "name": "triacylglycerol lipase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.3",
                "EC:3.1.1.79",
                "MetaCyc:RXN-19278",
                "Reactome:R-HSA-1482777 \"TAG is hydrolyzed to DAG by PNPLA2/3\"",
                "Reactome:R-HSA-163551 \"triacylglycerol + H2O -> diacylglycerol + fatty acid\"",
                "Reactome:R-HSA-5694109 \"LIPC dimer hydrolyses TAG to DAG and FA\"",
                "Reactome:R-HSA-8848338 \"PNPLA4 hydrolyzes TAG\"",
                "Reactome:R-HSA-8848339 \"PNPLA5 hydrolyzes TAG\"",
                "RHEA:12044"
              ],
              "previous": [
                "EC:3.1.1.3",
                "MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN",
                "Reactome:R-HSA-1482777 \"TAG is hydrolyzed to DAG by PNPLA2/3\"",
                "Reactome:R-HSA-163551 \"triacylglycerol + H2O -> diacylglycerol + fatty acid\"",
                "Reactome:R-HSA-5694109 \"LIPC dimer hydrolyses TAG to DAG and FA\"",
                "Reactome:R-HSA-8848338 \"PNPLA4 hydrolyzes TAG\"",
                "Reactome:R-HSA-8848339 \"PNPLA5 hydrolyzes TAG\"",
                "RHEA:12044"
              ]
            }
          }
        },
        {
          "id": "GO:0004828",
          "name": "serine-tRNA ligase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.1.1.11",
                "MetaCyc:SERINE--TRNA-LIGASE-RXN",
                "Reactome:R-HSA-379992 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\"",
                "Reactome:R-HSA-380239 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\""
              ],
              "previous": [
                "EC:6.1.1.11",
                "MetaCyc:SERINE--TRNA-LIGASE-RXN",
                "Reactome:R-HSA-379992 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\"",
                "Reactome:R-HSA-380239 \"serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate\"",
                "RHEA:12292"
              ]
            }
          }
        },
        {
          "id": "GO:0004838",
          "name": "L-tyrosine-2-oxoglutarate transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.6.1.5",
                "MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN",
                "Reactome:R-HSA-517444 \"p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate\"",
                "Reactome:R-HSA-71155 \"tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate\"",
                "RHEA:15093",
                "UM-BBD_reactionID:r0297"
              ],
              "previous": [
                "EC:2.6.1.5",
                "MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN",
                "Reactome:R-HSA-517444 \"p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate\"",
                "Reactome:R-HSA-71155 \"tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate\"",
                "RHEA:15093"
              ]
            }
          }
        },
        {
          "id": "GO:0004851",
          "name": "uroporphyrin-III C-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.107",
                "MetaCyc:RXN-13403",
                "RHEA:32459"
              ],
              "previous": [
                "EC:2.1.1.107",
                "MetaCyc:UROPORIIIMETHYLTRANSA-RXN",
                "RHEA:32459"
              ]
            }
          }
        },
        {
          "id": "GO:0004855",
          "name": "xanthine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.17.3.2",
                "MetaCyc:XANTHINE-OXIDASE-RXN",
                "Reactome:R-HSA-74258 \"XDH oxidizes xanthine to form urate\"",
                "Reactome:R-HSA-9748991 \"XDH oxidises 6MP to 6TU\"",
                "RHEA:21132"
              ],
              "previous": [
                "EC:1.17.3.2",
                "MetaCyc:XANTHINE-OXIDASE-RXN",
                "Reactome:R-HSA-74258 \"XDH oxidizes xanthine to form urate\"",
                "Reactome:R-HSA-9748991 \"XDH oxidises 6MP to 6TU\"",
                "RHEA:21132",
                "UM-BBD_enzymeID:e0781"
              ]
            }
          }
        },
        {
          "id": "GO:0005024",
          "name": "transforming growth factor beta receptor activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.11.30"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0008106",
          "name": "alcohol dehydrogenase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.2",
                "MetaCyc:ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN",
                "MetaCyc:RXN0-7119",
                "RHEA:15937"
              ],
              "previous": [
                "EC:1.1.1.2",
                "MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN",
                "MetaCyc:RXN0-7119",
                "RHEA:15937"
              ]
            }
          }
        },
        {
          "id": "GO:0008109",
          "name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.150",
                "MetaCyc:2.4.1.150-RXN",
                "RHEA:54820"
              ],
              "previous": [
                "EC:2.4.1.150",
                "EC:2.4.1.164",
                "MetaCyc:2.4.1.150-RXN",
                "RHEA:54820"
              ]
            }
          }
        },
        {
          "id": "GO:0008118",
          "name": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.3.6",
                "MetaCyc:2.4.99.6-RXN",
                "RHEA:52316"
              ],
              "previous": [
                "EC:2.4.3.6",
                "MetaCyc:2.4.99.6-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0008131",
          "name": "primary methylamine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.4.3.21",
                "KEGG_REACTION:R01853",
                "KEGG_REACTION:R02173",
                "KEGG_REACTION:R02613",
                "MetaCyc:RXN-10817",
                "MetaCyc:RXN-1401",
                "MetaCyc:RXN-9597",
                "Reactome:R-HSA-141186 \"MAOA:FAD oxidatively deaminates of 5HT\"",
                "Reactome:R-HSA-141200 \"MAOB:FAD oxidatively deaminates of PEA\"",
                "Reactome:R-HSA-141202 \"MAOB:FAD oxidatively deaminates TYR\"",
                "Reactome:R-HSA-374909 \"Catabolism of Noradrenaline\"",
                "Reactome:R-HSA-379382 \"MAOA:FAD deaminates DA to DOPAC\"",
                "Reactome:R-HSA-379395 \"MAOA:FAD deaminates 3MT to HVA\"",
                "Reactome:R-HSA-5603108 \"Defective MAOA does not oxidatively deaminate 5HT\"",
                "Reactome:R-HSA-5696146 \"AOC2 deaminates TYR\"",
                "Reactome:R-HSA-5696183 \"AOC3 deaminates BZAM\"",
                "RHEA:16153"
              ],
              "previous": [
                "EC:1.4.3.21",
                "KEGG_REACTION:R01853",
                "KEGG_REACTION:R02173",
                "KEGG_REACTION:R02529",
                "KEGG_REACTION:R02613",
                "MetaCyc:AMACETOXID-RXN",
                "MetaCyc:RXN-10817",
                "MetaCyc:RXN-1401",
                "MetaCyc:RXN-9597",
                "Reactome:R-HSA-141186 \"MAOA:FAD oxidatively deaminates of 5HT\"",
                "Reactome:R-HSA-141200 \"MAOB:FAD oxidatively deaminates of PEA\"",
                "Reactome:R-HSA-141202 \"MAOB:FAD oxidatively deaminates TYR\"",
                "Reactome:R-HSA-374909 \"Catabolism of Noradrenaline\"",
                "Reactome:R-HSA-379382 \"MAOA:FAD deaminates DA to DOPAC\"",
                "Reactome:R-HSA-379395 \"MAOA:FAD deaminates 3MT to HVA\"",
                "Reactome:R-HSA-5603108 \"Defective MAOA does not oxidatively deaminate 5HT\"",
                "Reactome:R-HSA-5696146 \"AOC2 deaminates TYR\"",
                "Reactome:R-HSA-5696183 \"AOC3 deaminates BZAM\"",
                "RHEA:16153",
                "RHEA:28186 {xref=\"skos:narrowMatch\"}"
              ]
            }
          }
        },
        {
          "id": "GO:0008239",
          "name": "dipeptidyl-peptidase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:3.4.14.1",
                "EC:3.4.14.2",
                "EC:3.4.14.4",
                "EC:3.4.14.5"
              ]
            }
          }
        },
        {
          "id": "GO:0008412",
          "name": "4-hydroxybenzoate polyprenyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.5.1.39",
                "MetaCyc:RXN-11368",
                "Reactome:R-HSA-2162192 \"PHB and all-E-10PrP2 are combined into DHB by COQ2\"",
                "RHEA:44504"
              ],
              "previous": [
                "EC:2.5.1.39",
                "MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN",
                "RHEA:27782"
              ]
            }
          }
        },
        {
          "id": "GO:0008440",
          "name": "inositol-1,4,5-trisphosphate 3-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.127",
                "EC:2.7.1.151",
                "KEGG_REACTION:R03433",
                "MetaCyc:2.7.1.127-RXN",
                "Reactome:R-HSA-1855153 \"I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol\"",
                "Reactome:R-HSA-1855233 \"I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus\"",
                "RHEA:11020"
              ],
              "previous": [
                "EC:2.7.1.127",
                "KEGG_REACTION:R03433",
                "MetaCyc:2.7.1.127-RXN",
                "Reactome:R-HSA-1855153 \"I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol\"",
                "Reactome:R-HSA-1855233 \"I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus\"",
                "RHEA:11020"
              ]
            }
          }
        },
        {
          "id": "GO:0008466",
          "name": "glycogenin glucosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.186",
                "Reactome:R-HSA-3322003 \"Autoglucosylation of GYG1 complexed with GYS1-b\"",
                "Reactome:R-HSA-3322014 \"Autoglucosylation of GYG2 complexed with GYS2-a\"",
                "Reactome:R-HSA-3322019 \"Autoglucosylation of GYG2 complexed with GYS2-b\"",
                "Reactome:R-HSA-3322025 \"Autoglucosylation of GYG1 complexed with GYS1-a\"",
                "Reactome:R-HSA-3814838 \"Defective GYG1 is not autoglucosyolated\""
              ],
              "previous": [
                "EC:2.4.1.186",
                "MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN",
                "Reactome:R-HSA-3322003 \"Autoglucosylation of GYG1 complexed with GYS1-b\"",
                "Reactome:R-HSA-3322014 \"Autoglucosylation of GYG2 complexed with GYS2-a\"",
                "Reactome:R-HSA-3322019 \"Autoglucosylation of GYG2 complexed with GYS2-b\"",
                "Reactome:R-HSA-3322025 \"Autoglucosylation of GYG1 complexed with GYS1-a\"",
                "Reactome:R-HSA-3814838 \"Defective GYG1 is not autoglucosyolated\"",
                "RHEA:23360"
              ]
            }
          }
        },
        {
          "id": "GO:0008532",
          "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.149",
                "MetaCyc:2.4.1.149-RXN",
                "MetaCyc:2.4.1.163-RXN",
                "Reactome:R-HSA-2025724 \"B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG\"",
                "RHEA:14389"
              ],
              "previous": [
                "EC:2.4.1.149",
                "MetaCyc:2.4.1.149-RXN",
                "MetaCyc:2.4.1.163-RXN",
                "Reactome:R-HSA-2025724 \"B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG\""
              ]
            }
          }
        },
        {
          "id": "GO:0008551",
          "name": "P-type cadmium transporter activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:7.2.2.21",
                "MetaCyc:3.6.3.3-RXN",
                "RHEA:12132"
              ],
              "previous": [
                "EC:7.2.2.21",
                "MetaCyc:3.6.3.3-RXN",
                "MetaCyc:RXN-21035",
                "RHEA:12132"
              ]
            }
          }
        },
        {
          "id": "GO:0008670",
          "name": "2,4-dienoyl-CoA reductase (NADPH) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.34"
              ],
              "previous": [
                "EC:1.3.1.34",
                "MetaCyc:DIENOYLCOAREDUCT-RXN",
                "RHEA:12136"
              ]
            }
          }
        },
        {
          "id": "GO:0008672",
          "name": "2-dehydro-3-deoxyglucarate aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.2.20",
                "MetaCyc:4.1.2.20-RXN",
                "RHEA:10268"
              ],
              "previous": [
                "EC:4.1.2.20",
                "MetaCyc:KDGALDOL-RXN",
                "RHEA:10268"
              ]
            }
          }
        },
        {
          "id": "GO:0008684",
          "name": "2-oxopent-4-enoate hydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.80",
                "MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN",
                "RHEA:22580",
                "UM-BBD_enzymeID:r0101"
              ],
              "previous": [
                "EC:4.2.1.80",
                "MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN",
                "RHEA:22580",
                "UM-BBD_enzymeID:e0078"
              ]
            }
          }
        },
        {
          "id": "GO:0008695",
          "name": "3-phenylpropionate dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.12.19",
                "MetaCyc:HCAMULTI-RXN",
                "RHEA:20357",
                "UM-BBD_enzymeID:r0434"
              ],
              "previous": [
                "EC:1.14.12.19",
                "MetaCyc:HCAMULTI-RXN",
                "RHEA:20357",
                "UM-BBD_enzymeID:e0307"
              ]
            }
          }
        },
        {
          "id": "GO:0008700",
          "name": "(R,S)-4-hydroxy-2-oxoglutarate aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.3.16",
                "Reactome:R-HSA-6784423 \"HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate\"",
                "RHEA:18169"
              ],
              "previous": [
                "EC:4.1.3.16",
                "MetaCyc:4OH2OXOGLUTARALDOL-RXN",
                "Reactome:R-HSA-6784423 \"HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate\"",
                "RHEA:18169"
              ]
            }
          }
        },
        {
          "id": "GO:0008701",
          "name": "4-hydroxy-2-oxovalerate aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.3.39",
                "KEGG_REACTION:R00750",
                "MetaCyc:MHPELY-RXN",
                "RHEA:22624",
                "UM-BBD_enzymeID:r0100"
              ],
              "previous": [
                "EC:4.1.3.39",
                "KEGG_REACTION:R00750",
                "MetaCyc:MHPELY-RXN",
                "RHEA:22624",
                "UM-BBD_enzymeID:e0077"
              ]
            }
          }
        },
        {
          "id": "GO:0008718",
          "name": "D-amino-acid dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:18125"
              ],
              "previous": [
                "MetaCyc:RXN-11193",
                "RHEA:18125"
              ]
            }
          }
        },
        {
          "id": "GO:0008725",
          "name": "DNA-3-methyladenine glycosylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.2.20",
                "EC:3.2.2.21",
                "MetaCyc:RXN0-5189"
              ],
              "previous": [
                "EC:3.2.2.20",
                "EC:3.2.2.21",
                "MetaCyc:3.2.2.21-RXN",
                "MetaCyc:RXN0-5189"
              ]
            }
          }
        },
        {
          "id": "GO:0008734",
          "name": "L-aspartate oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.4.3.16"
              ],
              "previous": [
                "EC:1.4.3.16",
                "MetaCyc:L-ASPARTATE-OXID-RXN",
                "MetaCyc:RXN-9772",
                "RHEA:25876"
              ]
            }
          }
        },
        {
          "id": "GO:0008775",
          "name": "acetate CoA-transferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.8.3.8",
                "MetaCyc:ACECOATRANS-RXN",
                "Reactome:R-HSA-2066788 \"Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase\"",
                "RHEA:13381",
                "UM-BBD_enzymeID:r0012"
              ],
              "previous": [
                "EC:2.8.3.8",
                "MetaCyc:ACECOATRANS-RXN",
                "Reactome:R-HSA-2066788 \"Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase\"",
                "RHEA:13381",
                "UM-BBD_enzymeID:e0012"
              ]
            }
          }
        },
        {
          "id": "GO:0008785",
          "name": "alkyl hydroperoxide reductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-1222526 \"AhpC reduces peroxidated lipids\""
              ],
              "previous": [
                "Reactome:R-HSA-1222526 \"AhpC reduces peroxidated lipids\"",
                "UM-BBD_reactionID:r0684"
              ]
            }
          }
        },
        {
          "id": "GO:0008793",
          "name": "aromatic-amino-acid transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.6.1.57",
                "MetaCyc:2.6.1.57-RXN",
                "RHEA:17533"
              ],
              "previous": [
                "EC:2.6.1.57",
                "MetaCyc:2.6.1.57-RXN",
                "RHEA:17533",
                "UM-BBD_reactionID:r0297"
              ]
            }
          }
        },
        {
          "id": "GO:0008806",
          "name": "carboxymethylenebutenolidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.45",
                "MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN",
                "RHEA:12372",
                "UM-BBD_enzymeID:r0110",
                "UM-BBD_enzymeID:r0286"
              ],
              "previous": [
                "EC:3.1.1.45",
                "MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN",
                "RHEA:12372",
                "UM-BBD_enzymeID:e0066"
              ]
            }
          }
        },
        {
          "id": "GO:0008838",
          "name": "diaminopropionate ammonia-lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.3.1.15",
                "MetaCyc:4.3.1.15-RXN"
              ],
              "previous": [
                "EC:4.3.1.15",
                "MetaCyc:4.3.1.15-RXN",
                "RHEA:22084"
              ]
            }
          }
        },
        {
          "id": "GO:0008863",
          "name": "formate dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.17.1.9",
                "KEGG_REACTION:R00519",
                "MetaCyc:1.2.1.2-RXN",
                "RHEA:15985",
                "UM-BBD_reactionID:r0103"
              ],
              "previous": [
                "EC:1.17.1.9",
                "KEGG_REACTION:R00519",
                "MetaCyc:1.2.1.2-RXN",
                "MetaCyc:FORMATEDEHYDROG-RXN",
                "RHEA:15985",
                "UM-BBD_reactionID:r0103"
              ]
            }
          }
        },
        {
          "id": "GO:0008880",
          "name": "glucuronate isomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.3.1.12",
                "MetaCyc:GLUCUROISOM-RXN"
              ],
              "previous": [
                "EC:5.3.1.12",
                "MetaCyc:GLUCUROISOM-RXN",
                "RHEA:13049"
              ]
            }
          }
        },
        {
          "id": "GO:0008901",
          "name": "ferredoxin hydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.12.7.2",
                "MetaCyc:HYDROG-RXN",
                "RHEA:17445"
              ],
              "previous": [
                "EC:1.12.7.2",
                "MetaCyc:HYDROG-RXN",
                "RHEA:17445",
                "UM-BBD_enzymeID:e0418"
              ]
            }
          }
        },
        {
          "id": "GO:0008919",
          "name": "lipopolysaccharide glucosyltransferase I activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.58",
                "MetaCyc:RXN0-5126",
                "RHEA:30015"
              ],
              "previous": [
                "EC:2.4.1.58",
                "MetaCyc:RXN0-5126"
              ]
            }
          }
        },
        {
          "id": "GO:0008973",
          "name": "phosphopentomutase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.4.2.7",
                "MetaCyc:PPENTOMUT-RXN",
                "Reactome:R-HSA-6787329 \"PGM2:Mg2+ isomerises R1P to R5P\"",
                "Reactome:R-HSA-8982667 \"PGM2:Mg2+ isomerises  dR1P to dR5P\""
              ],
              "previous": [
                "EC:5.4.2.7",
                "MetaCyc:PPENTOMUT-RXN",
                "Reactome:R-HSA-6787329 \"PGM2:Mg2+ isomerises R1P to R5P\"",
                "Reactome:R-HSA-8982667 \"PGM2:Mg2+ isomerises  dR1P to dR5P\"",
                "RHEA:18793"
              ]
            }
          }
        },
        {
          "id": "GO:0008999",
          "name": "peptide-alanine-alpha-N-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-17860",
                "RHEA:50500"
              ],
              "previous": [
                "MetaCyc:2.3.1.128-RXN",
                "RHEA:43756"
              ]
            }
          }
        },
        {
          "id": "GO:0009011",
          "name": "alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.21",
                "MetaCyc:GLYCOGENSYN-RXN",
                "RHEA:18189"
              ],
              "previous": [
                "EC:2.4.1.21",
                "MetaCyc:GLYCOGENSYN-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0009389",
          "name": "dimethyl sulfoxide reductase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "UM-BBD_reactionID:r0207"
              ]
            }
          }
        },
        {
          "id": "GO:0010283",
          "name": "pinoresinol reductase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:RXN-8678",
                "MetaCyc:RXN-8683"
              ]
            }
          }
        },
        {
          "id": "GO:0010284",
          "name": "lariciresinol reductase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:RXN-8679",
                "MetaCyc:RXN-8684"
              ]
            }
          }
        },
        {
          "id": "GO:0010303",
          "name": "limit dextrinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.1.142",
                "MetaCyc:3.2.1.142-RXN"
              ],
              "previous": [
                "EC:3.2.1.142",
                "MetaCyc:3.2.1.10-RXN",
                "MetaCyc:3.2.1.142-RXN",
                "MetaCyc:RXN-1824"
              ]
            }
          }
        },
        {
          "id": "GO:0010326",
          "name": "methionine-oxo-acid transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.6.1.88",
                "MetaCyc:R15-RXN",
                "RHEA:31763"
              ],
              "previous": [
                "MetaCyc:R15-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0010945",
          "name": "coenzyme A diphosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"",
                "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"",
                "Reactome:R-HSA-9837354 \"NUDT8 hydrolyzes CoA-SH to PPANT\""
              ],
              "previous": [
                "MetaCyc:RXN-10811",
                "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"",
                "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"",
                "Reactome:R-HSA-9837354 \"NUDT8 hydrolyzes CoA-SH to PPANT\"",
                "RHEA:50044"
              ]
            }
          }
        },
        {
          "id": "GO:0015049",
          "name": "methane monooxygenase [NAD(P)H] activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.25",
                "MetaCyc:METHANE-MONOOXYGENASE-RXN",
                "UM-BBD_enzymeID:r0237"
              ],
              "previous": [
                "EC:1.14.13.25",
                "MetaCyc:METHANE-MONOOXYGENASE-RXN",
                "UM-BBD_enzymeID:e0007"
              ]
            }
          }
        },
        {
          "id": "GO:0015451",
          "name": "decarboxylation-driven active transmembrane transporter activity",
          "changes": {
            "xrefs": {
              "current": [
                "TC:3.B"
              ],
              "previous": [
                "EC:7.2.4.1",
                "EC:7.2.4.2",
                "EC:7.2.4.3",
                "EC:7.2.4.4",
                "EC:7.2.4.5",
                "TC:3.B"
              ]
            }
          }
        },
        {
          "id": "GO:0015614",
          "name": "ABC-type D-xylose transporter activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:7.5.2.10",
                "EC:7.5.2.13",
                "MetaCyc:ABC-33-RXN",
                "RHEA:29899"
              ],
              "previous": [
                "EC:7.5.2.10",
                "MetaCyc:ABC-33-RXN",
                "RHEA:29899"
              ]
            }
          }
        },
        {
          "id": "GO:0015625",
          "name": "ABC-type ferric hydroxamate transporter activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:7.2.2.16",
                "MetaCyc:ABC-11-RXN"
              ],
              "previous": [
                "EC:7.2.2.16",
                "MetaCyc:3.6.3.34-RXN",
                "MetaCyc:ABC-11-RXN",
                "MetaCyc:ABC-9-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0015927",
          "name": "trehalase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:TREHALA-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0015929",
          "name": "hexosaminidase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:3.2.1.52-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0016157",
          "name": "sucrose synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.13",
                "MetaCyc:SUCROSE-SYNTHASE-RXN",
                "RHEA:16241"
              ],
              "previous": [
                "EC:2.4.1.13",
                "MetaCyc:SUCROSE-SYNTHASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0016206",
          "name": "catechol O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.6",
                "MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN",
                "Reactome:R-HSA-175983 \"COMT transfer CH3 from AdoMet to 3,4DHBNZ\"",
                "Reactome:R-HSA-8955010 \"LRTOMT transfers Met to DA, forming 3MT\"",
                "RHEA:17877"
              ],
              "previous": [
                "EC:2.1.1.6",
                "MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN",
                "MetaCyc:RXN-10870",
                "MetaCyc:RXN-9017",
                "Reactome:R-HSA-175983 \"COMT transfer CH3 from AdoMet to 3,4DHBNZ\"",
                "Reactome:R-HSA-8955010 \"LRTOMT transfers Met to DA, forming 3MT\"",
                "RHEA:17877"
              ]
            }
          }
        },
        {
          "id": "GO:0016211",
          "name": "ammonia ligase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:6.3.1.-"
              ]
            }
          }
        },
        {
          "id": "GO:0016212",
          "name": "kynurenine-oxoglutarate transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.6.1.7",
                "Reactome:R-HSA-893583 \"kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate\"",
                "Reactome:R-HSA-893596 \"PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu\"",
                "Reactome:R-HSA-901097 \"kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]\""
              ],
              "previous": [
                "EC:2.6.1.7",
                "MetaCyc:2.6.1.7-RXN",
                "Reactome:R-HSA-893583 \"kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate\"",
                "Reactome:R-HSA-893596 \"PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu\"",
                "Reactome:R-HSA-901097 \"kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]\"",
                "RHEA:20964"
              ]
            }
          }
        },
        {
          "id": "GO:0016412",
          "name": "serine O-acyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:68272"
              ],
              "previous": [
                "EC:2.3.1.30"
              ]
            }
          }
        },
        {
          "id": "GO:0016419",
          "name": "S-malonyltransferase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:2.3.1.39"
              ]
            }
          }
        },
        {
          "id": "GO:0016712",
          "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.-",
                "Reactome:R-HSA-211966 \"CYP2D6 4-hydroxylates debrisoquine\""
              ],
              "previous": [
                "EC:1.14.14.-",
                "Reactome:R-HSA-211966 \"CYP2D6 4-hydroxylates debrisoquine\"",
                "UM-BBD_enzymeID:e0551"
              ]
            }
          }
        },
        {
          "id": "GO:0016805",
          "name": "dipeptidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.4.13.-",
                "MetaCyc:3.4.13.18-RXN",
                "Reactome:R-HSA-266012 \"LTD4 is converted to LTE4 by DPEP1/2\"",
                "Reactome:R-HSA-5433067 \"DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG\"",
                "Reactome:R-HSA-5693783 \"NAALADases hydrolyse NAAG\"",
                "Reactome:R-HSA-9026771 \"DPEP hydrolyses MCTR2 to MCTR3\""
              ],
              "previous": [
                "EC:3.4.13.-",
                "Reactome:R-HSA-266012 \"LTD4 is converted to LTE4 by DPEP1/2\"",
                "Reactome:R-HSA-5433067 \"DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG\"",
                "Reactome:R-HSA-5693783 \"NAALADases hydrolyse NAAG\"",
                "Reactome:R-HSA-9026771 \"DPEP hydrolyses MCTR2 to MCTR3\""
              ]
            }
          }
        },
        {
          "id": "GO:0016937",
          "name": "short-chain fatty acyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.8.1",
                "KEGG_REACTION:R01178",
                "MetaCyc:RXN-13449",
                "RHEA:47196"
              ],
              "previous": [
                "EC:1.3.8.1",
                "RHEA:47196"
              ]
            }
          }
        },
        {
          "id": "GO:0017040",
          "name": "N-acylsphingosine amidohydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.1.23",
                "MetaCyc:CERAMIDASE-RXN",
                "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"",
                "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"",
                "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"",
                "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"",
                "Reactome:R-HSA-428262 \"ACER3 hydrolyzes phytoceramide\"",
                "RHEA:20856"
              ],
              "previous": [
                "EC:3.5.1.23",
                "MetaCyc:CERAMIDASE-RXN",
                "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"",
                "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"",
                "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"",
                "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"",
                "RHEA:20856"
              ]
            }
          }
        },
        {
          "id": "GO:0017042",
          "name": "glycosylceramidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.1.62",
                "MetaCyc:GLYCOSYLCERAMIDASE-RXN"
              ],
              "previous": [
                "EC:3.2.1.62",
                "MetaCyc:GALACTOSYLCERAMIDASE-RXN",
                "MetaCyc:GLYCOSYLCERAMIDASE-RXN",
                "MetaCyc:RXN-22900"
              ]
            }
          }
        },
        {
          "id": "GO:0017099",
          "name": "very-long-chain fatty acyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.8.9",
                "MetaCyc:RXN-13451",
                "Reactome:R-HSA-548831 \"TECR,TECRL dehydrogenate TOD-CoA to ST-CoA\"",
                "RHEA:19181"
              ],
              "previous": [
                "EC:1.3.8.9",
                "Reactome:R-HSA-548831 \"TECR,TECRL dehydrogenate TOD-CoA to ST-CoA\"",
                "RHEA:19181"
              ]
            }
          }
        },
        {
          "id": "GO:0018423",
          "name": "protein C-terminal leucine carboxyl O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-8856945 \"PP2A methylation by LCMT1\""
              ],
              "previous": [
                "Reactome:R-HSA-8856945 \"PP2A methylation by LCMT1\"",
                "RHEA:48544 {comment=\"skos:narrowMatch\"}"
              ]
            }
          }
        },
        {
          "id": "GO:0018456",
          "name": "aryl-alcohol dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.90",
                "MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN",
                "RHEA:12076"
              ],
              "previous": [
                "EC:1.1.1.90",
                "MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN",
                "RHEA:12076",
                "UM-BBD_enzymeID:e0019"
              ]
            }
          }
        },
        {
          "id": "GO:0018477",
          "name": "benzaldehyde dehydrogenase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.2.1.7",
                "MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN",
                "RHEA:21660",
                "UM-BBD_enzymeID:r0214",
                "UM-BBD_enzymeID:r0222"
              ],
              "previous": [
                "EC:1.2.1.7",
                "MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN",
                "RHEA:21660",
                "UM-BBD_enzymeID:e0079"
              ]
            }
          }
        },
        {
          "id": "GO:0018485",
          "name": "salicylaldehyde dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.2.1.65",
                "MetaCyc:1.2.1.65-RXN",
                "RHEA:18537",
                "UM-BBD_enzymeID:r0339"
              ],
              "previous": [
                "EC:1.2.1.65",
                "MetaCyc:1.2.1.65-RXN",
                "RHEA:18537",
                "UM-BBD_enzymeID:e0256"
              ]
            }
          }
        },
        {
          "id": "GO:0018489",
          "name": "vanillate monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.82",
                "KEGG_REACTION:R05274",
                "MetaCyc:RXN-10891",
                "RHEA:13021",
                "UM-BBD_reactionID:r0146"
              ],
              "previous": [
                "EC:1.14.13.82",
                "KEGG_REACTION:R05274",
                "MetaCyc:RXN-10891",
                "MetaCyc:RXN-2",
                "RHEA:13021",
                "UM-BBD_reactionID:r0146"
              ]
            }
          }
        },
        {
          "id": "GO:0018498",
          "name": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.87",
                "MetaCyc:PHENPRODIOLDEHYDROG-RXN",
                "UM-BBD_enzymeID:r0436",
                "UM-BBD_enzymeID:r1620"
              ],
              "previous": [
                "EC:1.3.1.87",
                "MetaCyc:PHENPRODIOLDEHYDROG-RXN",
                "UM-BBD_enzymeID:e0308"
              ]
            }
          }
        },
        {
          "id": "GO:0018504",
          "name": "cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.19",
                "MetaCyc:1.3.1.19-RXN",
                "RHEA:15457",
                "UM-BBD_enzymeID:r0080"
              ],
              "previous": [
                "EC:1.3.1.19",
                "MetaCyc:1.3.1.19-RXN",
                "RHEA:15457",
                "UM-BBD_enzymeID:e0060"
              ]
            }
          }
        },
        {
          "id": "GO:0018505",
          "name": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.29",
                "MetaCyc:1.3.1.29-RXN",
                "RHEA:11832"
              ],
              "previous": [
                "EC:1.3.1.29",
                "MetaCyc:1.3.1.29-RXN",
                "RHEA:11832",
                "UM-BBD_enzymeID:e0122"
              ]
            }
          }
        },
        {
          "id": "GO:0018506",
          "name": "maleylacetate reductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.32",
                "MetaCyc:MALEYLACETATE-REDUCTASE-RXN",
                "UM-BBD_enzymeID:r0099"
              ],
              "previous": [
                "EC:1.3.1.32",
                "MetaCyc:MALEYLACETATE-REDUCTASE-RXN",
                "UM-BBD_enzymeID:e0063"
              ]
            }
          }
        },
        {
          "id": "GO:0018509",
          "name": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.56",
                "MetaCyc:1.3.1.56-RXN",
                "RHEA:17033",
                "UM-BBD_enzymeID:r0389"
              ],
              "previous": [
                "EC:1.3.1.56",
                "MetaCyc:1.3.1.56-RXN",
                "RHEA:17033",
                "UM-BBD_enzymeID:e0134"
              ]
            }
          }
        },
        {
          "id": "GO:0018535",
          "name": "nicotine dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.99.4",
                "MetaCyc:NICOTINE-DEHYDROGENASE-RXN",
                "RHEA:14769",
                "UM-BBD_enzymeID:r0978",
                "UM-BBD_enzymeID:r0979"
              ],
              "previous": [
                "EC:1.5.99.4",
                "MetaCyc:NICOTINE-DEHYDROGENASE-RXN",
                "RHEA:14769",
                "UM-BBD_enzymeID:e0337"
              ]
            }
          }
        },
        {
          "id": "GO:0018541",
          "name": "p-benzoquinone reductase (NADPH) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.6.5.6",
                "KEGG_REACTION:R05244",
                "MetaCyc:1.6.5.6-RXN",
                "RHEA:23488"
              ],
              "previous": [
                "EC:1.6.5.6",
                "KEGG_REACTION:R05244",
                "MetaCyc:1.6.5.6-RXN",
                "RHEA:23488",
                "UM-BBD_enzymeID:e0422"
              ]
            }
          }
        },
        {
          "id": "GO:0018546",
          "name": "nitrobenzene nitroreductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.7.1.16",
                "MetaCyc:RXN-8815",
                "MetaCyc:RXN-8833",
                "RHEA:52884",
                "UM-BBD_enzymeID:r0303"
              ],
              "previous": [
                "EC:1.7.1.16",
                "MetaCyc:RXN-8815",
                "MetaCyc:RXN-8833",
                "RHEA:52884",
                "UM-BBD_enzymeID:e0245"
              ]
            }
          }
        },
        {
          "id": "GO:0018554",
          "name": "1,2-dihydroxynaphthalene dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.56",
                "RHEA:27310",
                "UM-BBD_enzymeID:r0336"
              ],
              "previous": [
                "EC:1.13.11.56",
                "RHEA:27310",
                "UM-BBD_enzymeID:e0255"
              ]
            }
          }
        },
        {
          "id": "GO:0018576",
          "name": "catechol 1,2-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.1",
                "MetaCyc:CATECHOL-12-DIOXYGENASE-RXN",
                "RHEA:23852",
                "UM-BBD_enzymeID:r0601"
              ],
              "previous": [
                "EC:1.13.11.1",
                "MetaCyc:CATECHOL-12-DIOXYGENASE-RXN",
                "RHEA:23852",
                "UM-BBD_enzymeID:e0064"
              ]
            }
          }
        },
        {
          "id": "GO:0018577",
          "name": "catechol 2,3-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.2",
                "MetaCyc:CATECHOL-23-DIOXYGENASE-RXN",
                "RHEA:17337",
                "UM-BBD_enzymeID:r0307"
              ],
              "previous": [
                "EC:1.13.11.2",
                "MetaCyc:CATECHOL-23-DIOXYGENASE-RXN",
                "RHEA:17337",
                "UM-BBD_enzymeID:e0156"
              ]
            }
          }
        },
        {
          "id": "GO:0018583",
          "name": "biphenyl-2,3-diol 1,2-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.39",
                "MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN",
                "RHEA:14413",
                "UM-BBD_enzymeID:r0390"
              ],
              "previous": [
                "EC:1.13.11.39",
                "MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN",
                "RHEA:14413",
                "UM-BBD_enzymeID:e0127"
              ]
            }
          }
        },
        {
          "id": "GO:0018597",
          "name": "ammonia monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.99.39",
                "RHEA:27341"
              ],
              "previous": [
                "EC:1.14.99.39",
                "RHEA:27341",
                "UM-BBD_enzymeID:e0061"
              ]
            }
          }
        },
        {
          "id": "GO:0018610",
          "name": "dibenzofuran 4,4a-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:R606-RXN",
                "RHEA:42460",
                "UM-BBD_enzymeID:r0026"
              ],
              "previous": [
                "MetaCyc:R606-RXN",
                "RHEA:42460",
                "UM-BBD_enzymeID:e0030"
              ]
            }
          }
        },
        {
          "id": "GO:0018623",
          "name": "benzoate 1,2-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.12.10",
                "MetaCyc:BENZOATE-12-DIOXYGENASE-RXN",
                "RHEA:12633",
                "UM-BBD_enzymeID:r0245"
              ],
              "previous": [
                "EC:1.14.12.10",
                "MetaCyc:BENZOATE-12-DIOXYGENASE-RXN",
                "RHEA:12633",
                "UM-BBD_enzymeID:e0154"
              ]
            }
          }
        },
        {
          "id": "GO:0018624",
          "name": "toluene dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.12.11",
                "KEGG_REACTION:R03559",
                "MetaCyc:TOLUENE-DIOXYGENASE-RXN",
                "RHEA:16737",
                "UM-BBD_enzymeID:r0253"
              ],
              "previous": [
                "EC:1.14.12.11",
                "KEGG_REACTION:R03559",
                "MetaCyc:TOLUENE-DIOXYGENASE-RXN",
                "RHEA:16737",
                "UM-BBD_enzymeID:e0155"
              ]
            }
          }
        },
        {
          "id": "GO:0018625",
          "name": "naphthalene 1,2-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.12.12",
                "MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN",
                "RHEA:19173",
                "UM-BBD_enzymeID:r0334"
              ],
              "previous": [
                "EC:1.14.12.12",
                "MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN",
                "RHEA:19173",
                "UM-BBD_enzymeID:e0002"
              ]
            }
          }
        },
        {
          "id": "GO:0018638",
          "name": "toluene 4-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.236",
                "RHEA:41380",
                "UM-BBD_enzymeID:r0255"
              ],
              "previous": [
                "EC:1.14.13.236",
                "RHEA:41380",
                "UM-BBD_enzymeID:e0225"
              ]
            }
          }
        },
        {
          "id": "GO:0018640",
          "name": "dibenzothiophene monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-621",
                "RHEA:49076",
                "UM-BBD_enzymeID:r0037"
              ],
              "previous": [
                "MetaCyc:RXN-621",
                "RHEA:49076",
                "UM-BBD_enzymeID:e0214"
              ]
            }
          }
        },
        {
          "id": "GO:0018644",
          "name": "toluene 2-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.243",
                "MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN",
                "RHEA:20349",
                "UM-BBD_enzymeID:r0260"
              ],
              "previous": [
                "EC:1.14.13.243",
                "MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN",
                "RHEA:20349",
                "UM-BBD_enzymeID:e0222"
              ]
            }
          }
        },
        {
          "id": "GO:0018645",
          "name": "alkene monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.69",
                "MetaCyc:1.14.13.69-RXN",
                "RHEA:11792",
                "UM-BBD_enzymeID:r0856",
                "UM-BBD_enzymeID:r0857"
              ],
              "previous": [
                "EC:1.14.13.69",
                "MetaCyc:1.14.13.69-RXN",
                "RHEA:11792",
                "UM-BBD_enzymeID:e0039"
              ]
            }
          }
        },
        {
          "id": "GO:0018658",
          "name": "salicylate 1-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.1",
                "MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN",
                "RHEA:11004",
                "UM-BBD_enzymeID:r0340"
              ],
              "previous": [
                "EC:1.14.13.1",
                "MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN",
                "RHEA:11004",
                "UM-BBD_enzymeID:e0149"
              ]
            }
          }
        },
        {
          "id": "GO:0018662",
          "name": "phenol 2-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.7",
                "MetaCyc:PHENOL-2-MONOOXYGENASE-RXN",
                "RHEA:17061",
                "UM-BBD_enzymeID:r0696"
              ],
              "previous": [
                "EC:1.14.13.7",
                "MetaCyc:PHENOL-2-MONOOXYGENASE-RXN",
                "RHEA:17061",
                "UM-BBD_enzymeID:e0208"
              ]
            }
          }
        },
        {
          "id": "GO:0018666",
          "name": "2,4-dichlorophenol 6-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.20",
                "MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN",
                "RHEA:20920",
                "UM-BBD_enzymeID:r0275"
              ],
              "previous": [
                "EC:1.14.13.20",
                "MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN",
                "RHEA:20920",
                "UM-BBD_enzymeID:e0152"
              ]
            }
          }
        },
        {
          "id": "GO:0018677",
          "name": "pentachlorophenol monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.50",
                "MetaCyc:PCP4MONO-RXN",
                "RHEA:18685",
                "UM-BBD_enzymeID:r0313"
              ],
              "previous": [
                "EC:1.14.13.50",
                "MetaCyc:PCP4MONO-RXN",
                "RHEA:18685",
                "UM-BBD_enzymeID:e0148"
              ]
            }
          }
        },
        {
          "id": "GO:0018683",
          "name": "camphor 5-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.15.1",
                "MetaCyc:R541-RXN",
                "RHEA:13525",
                "UM-BBD_enzymeID:r0426"
              ],
              "previous": [
                "EC:1.14.15.1",
                "MetaCyc:R541-RXN",
                "RHEA:13525",
                "UM-BBD_enzymeID:e0300"
              ]
            }
          }
        },
        {
          "id": "GO:0018684",
          "name": "2,5-diketocamphane 1,2-monooxygenase",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.108",
                "MetaCyc:R543-RXN",
                "RHEA:34415",
                "UM-BBD_enzymeID:r0428"
              ],
              "previous": [
                "EC:1.14.14.108",
                "MetaCyc:R543-RXN",
                "RHEA:34415",
                "UM-BBD_enzymeID:e0302"
              ]
            }
          }
        },
        {
          "id": "GO:0018685",
          "name": "alkane 1-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.15.3",
                "MetaCyc:ALKANE-1-MONOOXYGENASE-RXN",
                "RHEA:19341",
                "UM-BBD_enzymeID:r0021"
              ],
              "previous": [
                "EC:1.14.15.3",
                "MetaCyc:ALKANE-1-MONOOXYGENASE-RXN",
                "RHEA:19341",
                "UM-BBD_enzymeID:e0022"
              ]
            }
          }
        },
        {
          "id": "GO:0018687",
          "name": "biphenyl 2,3-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.12.18",
                "MetaCyc:1.14.12.18-RXN",
                "RHEA:18165",
                "UM-BBD_enzymeID:r0388"
              ],
              "previous": [
                "EC:1.14.12.18",
                "MetaCyc:1.14.12.18-RXN",
                "RHEA:18165",
                "UM-BBD_enzymeID:e0089"
              ]
            }
          }
        },
        {
          "id": "GO:0018708",
          "name": "thiol S-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.9",
                "MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN",
                "Reactome:R-HSA-175976 \"TMT transfers CH3 from AdoMet to BME\"",
                "RHEA:18277"
              ],
              "previous": [
                "EC:2.1.1.9",
                "MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN",
                "Reactome:R-HSA-175976 \"TMT transfers CH3 from AdoMet to BME\"",
                "RHEA:18277",
                "UM-BBD_enzymeID:e0146"
              ]
            }
          }
        },
        {
          "id": "GO:0018740",
          "name": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.13.1.3",
                "KEGG_REACTION:R07311",
                "MetaCyc:RXN-624",
                "RHEA:12945",
                "UM-BBD_enzymeID:r0236"
              ],
              "previous": [
                "EC:3.13.1.3",
                "KEGG_REACTION:R07311",
                "MetaCyc:RXN-624",
                "RHEA:12945",
                "UM-BBD_enzymeID:e0216"
              ]
            }
          }
        },
        {
          "id": "GO:0018761",
          "name": "bromoxynil nitrilase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.5.6",
                "KEGG_REACTION:R04349",
                "MetaCyc:3.5.5.6-RXN",
                "RHEA:22100",
                "UM-BBD_enzymeID:r0548"
              ],
              "previous": [
                "EC:3.5.5.6",
                "KEGG_REACTION:R04349",
                "MetaCyc:3.5.5.6-RXN",
                "RHEA:22100",
                "UM-BBD_enzymeID:e0357"
              ]
            }
          }
        },
        {
          "id": "GO:0018763",
          "name": "hydroxydechloroatrazine ethylaminohydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.4.43",
                "MetaCyc:R122-RXN",
                "RHEA:23092",
                "UM-BBD_enzymeID:r0114"
              ],
              "previous": [
                "EC:3.5.4.43",
                "MetaCyc:R122-RXN",
                "RHEA:23092",
                "UM-BBD_enzymeID:e0085"
              ]
            }
          }
        },
        {
          "id": "GO:0018764",
          "name": "N-isopropylammelide isopropylaminohydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.4.42",
                "MetaCyc:R123-RXN",
                "RHEA:23608",
                "UM-BBD_enzymeID:r0115"
              ],
              "previous": [
                "EC:3.5.4.42",
                "MetaCyc:R123-RXN",
                "RHEA:23608",
                "UM-BBD_enzymeID:e0086"
              ]
            }
          }
        },
        {
          "id": "GO:0018768",
          "name": "2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.7.1.13",
                "MetaCyc:RXN-11543",
                "RHEA:27870",
                "UM-BBD_reactionID:r0458"
              ],
              "previous": [
                "EC:3.7.1.13",
                "UM-BBD_reactionID:r0458"
              ]
            }
          }
        },
        {
          "id": "GO:0018774",
          "name": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.7.1.8",
                "MetaCyc:3.7.1.8-RXN",
                "RHEA:17161",
                "UM-BBD_enzymeID:r0391"
              ],
              "previous": [
                "EC:3.7.1.8",
                "MetaCyc:3.7.1.8-RXN",
                "RHEA:17161",
                "UM-BBD_enzymeID:e0033"
              ]
            }
          }
        },
        {
          "id": "GO:0018775",
          "name": "2-hydroxymuconate-semialdehyde hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.7.1.9",
                "MetaCyc:3.7.1.9-RXN",
                "RHEA:14549",
                "UM-BBD_enzymeID:r1671"
              ],
              "previous": [
                "EC:3.7.1.9",
                "MetaCyc:3.7.1.9-RXN",
                "RHEA:14549",
                "UM-BBD_enzymeID:e0139"
              ]
            }
          }
        },
        {
          "id": "GO:0018785",
          "name": "haloacetate dehalogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.8.1.3",
                "MetaCyc:HALOACETATE-DEHALOGENASE-RXN",
                "RHEA:11044",
                "UM-BBD_enzymeID:r0004",
                "UM-BBD_enzymeID:r1028"
              ],
              "previous": [
                "EC:3.8.1.3",
                "MetaCyc:HALOACETATE-DEHALOGENASE-RXN",
                "RHEA:11044",
                "UM-BBD_enzymeID:e0006"
              ]
            }
          }
        },
        {
          "id": "GO:0018786",
          "name": "haloalkane dehalogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.8.1.5",
                "MetaCyc:HALOALKANE-DEHALOGENASE-RXN",
                "RHEA:19081",
                "UM-BBD_enzymeID:r0001"
              ],
              "previous": [
                "EC:3.8.1.5",
                "MetaCyc:HALOALKANE-DEHALOGENASE-RXN",
                "RHEA:19081",
                "UM-BBD_enzymeID:e0003"
              ]
            }
          }
        },
        {
          "id": "GO:0018787",
          "name": "4-chlorobenzoyl-CoA dehalogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.8.1.7",
                "MetaCyc:3.8.1.7-RXN",
                "RHEA:14853",
                "UM-BBD_enzymeID:r0140"
              ],
              "previous": [
                "EC:3.8.1.7",
                "MetaCyc:3.8.1.7-RXN",
                "RHEA:14853",
                "UM-BBD_enzymeID:e0113"
              ]
            }
          }
        },
        {
          "id": "GO:0018796",
          "name": "4,5-dihydroxyphthalate decarboxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.1.55",
                "MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN",
                "RHEA:24184",
                "UM-BBD_enzymeID:r0149"
              ],
              "previous": [
                "EC:4.1.1.55",
                "MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN",
                "RHEA:24184",
                "UM-BBD_enzymeID:e0106"
              ]
            }
          }
        },
        {
          "id": "GO:0018805",
          "name": "benzylsuccinate synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.99.11",
                "KEGG_REACTION:R05598",
                "MetaCyc:RXN-863",
                "RHEA:10416",
                "UM-BBD_enzymeID:r0328"
              ],
              "previous": [
                "EC:4.1.99.11",
                "KEGG_REACTION:R05598",
                "MetaCyc:RXN-863",
                "RHEA:10416",
                "UM-BBD_enzymeID:e0259"
              ]
            }
          }
        },
        {
          "id": "GO:0018813",
          "name": "trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.2.45",
                "RHEA:27389",
                "UM-BBD_enzymeID:r0338"
              ],
              "previous": [
                "EC:4.1.2.45",
                "RHEA:27389",
                "UM-BBD_enzymeID:e0257"
              ]
            }
          }
        },
        {
          "id": "GO:0018822",
          "name": "nitrile hydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.84",
                "MetaCyc:NITRILE-HYDRATASE-RXN",
                "RHEA:12673"
              ],
              "previous": [
                "EC:4.2.1.84",
                "MetaCyc:NITRILE-HYDRATASE-RXN",
                "RHEA:12673",
                "UM-BBD_enzymeID:e0067"
              ]
            }
          }
        },
        {
          "id": "GO:0018836",
          "name": "alkylmercury lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.99.1.2",
                "MetaCyc:ALKYLMERCURY-LYASE-RXN",
                "RHEA:18777"
              ],
              "previous": [
                "EC:4.99.1.2",
                "MetaCyc:ALKYLMERCURY-LYASE-RXN",
                "RHEA:18777",
                "UM-BBD_enzymeID:e0055"
              ]
            }
          }
        },
        {
          "id": "GO:0018849",
          "name": "muconate cycloisomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.5.1.1",
                "MetaCyc:MUCONATE-CYCLOISOMERASE-RXN",
                "RHEA:30031"
              ],
              "previous": [
                "EC:5.5.1.1",
                "MetaCyc:MUCONATE-CYCLOISOMERASE-RXN",
                "RHEA:30031",
                "UM-BBD_enzymeID:e0133"
              ]
            }
          }
        },
        {
          "id": "GO:0018850",
          "name": "chloromuconate cycloisomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.5.1.7",
                "RHEA:11032"
              ],
              "previous": [
                "EC:5.5.1.7",
                "RHEA:11032",
                "UM-BBD_enzymeID:e0065"
              ]
            }
          }
        },
        {
          "id": "GO:0019010",
          "name": "farnesoic acid O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.325"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0019116",
          "name": "hydroxy-nicotine oxidase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:1.5.3.6"
              ]
            }
          }
        },
        {
          "id": "GO:0019141",
          "name": "2-dehydropantolactone reductase (B-specific) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.214",
                "MetaCyc:1.1.1.168-RXN"
              ],
              "previous": [
                "EC:1.1.1.214",
                "MetaCyc:1.1.1.209-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0019171",
          "name": "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.59",
                "MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN",
                "RHEA:13097"
              ],
              "previous": [
                "EC:4.2.1.59",
                "MetaCyc:4.2.1.59-RXN",
                "RHEA:13097"
              ]
            }
          }
        },
        {
          "id": "GO:0019875",
          "name": "6-aminohexanoate-dimer hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.1.46",
                "MetaCyc:RXN-3962",
                "RHEA:21364",
                "UM-BBD_enzymeID:r1096"
              ],
              "previous": [
                "EC:3.5.1.46",
                "MetaCyc:RXN-3962",
                "RHEA:21364",
                "UM-BBD_enzymeID:e0673"
              ]
            }
          }
        },
        {
          "id": "GO:0030058",
          "name": "aliphatic amine dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:51128"
              ],
              "previous": [
                "RHEA:51128",
                "UM-BBD_enzymeID:e0058"
              ]
            }
          }
        },
        {
          "id": "GO:0031956",
          "name": "medium-chain fatty acid-CoA ligase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.2.1.2",
                "Reactome:R-HSA-8875013 \"ACSM3,ACSM6 ligate CoA to BUT\"",
                "RHEA:48340"
              ],
              "previous": [
                "EC:6.2.1.2",
                "MetaCyc:BUTYRATE--COA-LIGASE-RXN",
                "Reactome:R-HSA-8875013 \"ACSM3,ACSM6 ligate CoA to BUT\"",
                "RHEA:48340"
              ]
            }
          }
        },
        {
          "id": "GO:0032942",
          "name": "inositol-1,4,5,6-tetrakisphosphate 2-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-7182"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033230",
          "name": "ABC-type cysteine transporter activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN0-3",
                "RHEA:29783"
              ],
              "previous": [
                "MetaCyc:RXN0-3",
                "RHEA:32795"
              ]
            }
          }
        },
        {
          "id": "GO:0033727",
          "name": "aldehyde dehydrogenase (FAD-independent) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.2.99.7",
                "MetaCyc:1.2.99.7-RXN"
              ],
              "previous": [
                "EC:1.2.99.7",
                "MetaCyc:1.2.99.3-RXN",
                "MetaCyc:1.2.99.7-RXN",
                "MetaCyc:CARBOXYLATE-REDUCTASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0033773",
          "name": "isoflavone 2'-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.90",
                "MetaCyc:RXN-11846",
                "RHEA:18849"
              ],
              "previous": [
                "EC:1.14.14.90",
                "MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN",
                "RHEA:18849"
              ]
            }
          }
        },
        {
          "id": "GO:0033799",
          "name": "myricetin 3'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.267",
                "KEGG_REACTION:R06815",
                "MetaCyc:RXN-8451",
                "RHEA:25629"
              ],
              "previous": [
                "EC:2.1.1.267",
                "KEGG_REACTION:R06815",
                "MetaCyc:RXN-13912",
                "MetaCyc:RXN-8451",
                "RHEA:25629"
              ]
            }
          }
        },
        {
          "id": "GO:0033840",
          "name": "alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.242",
                "MetaCyc:2.4.1.242-RXN",
                "MetaCyc:RXN-14378",
                "RHEA:15873"
              ],
              "previous": [
                "EC:2.4.1.242",
                "MetaCyc:2.4.1.242-RXN",
                "RHEA:15873"
              ]
            }
          }
        },
        {
          "id": "GO:0033878",
          "name": "hormone-sensitive lipase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.79"
              ],
              "previous": [
                "EC:3.1.1.79",
                "MetaCyc:STEROL-ESTERASE-RXN",
                "MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0033897",
          "name": "ribonuclease T2 activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.6.1.19",
                "MetaCyc:3.1.27.5-RXN",
                "RHEA:68052"
              ],
              "previous": [
                "EC:4.6.1.19",
                "MetaCyc:3.1.27.5-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0033976",
          "name": "2-haloacid dehalogenase (configuration-inverting) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.8.1.10",
                "MetaCyc:2-HALOACID-DEHALOGENASE-RXN"
              ],
              "previous": [
                "MetaCyc:2-HALOACID-DEHALOGENASE-RXN",
                "MetaCyc:RXN-6264"
              ]
            }
          }
        },
        {
          "id": "GO:0033987",
          "name": "2-hydroxyisoflavanone dehydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.105",
                "MetaCyc:RXN-3284"
              ],
              "previous": [
                "EC:4.2.1.105",
                "MetaCyc:RXN-3284",
                "RHEA:16445"
              ]
            }
          }
        },
        {
          "id": "GO:0034004",
          "name": "germacradienol synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.3.22",
                "KEGG_REACTION:R07647",
                "RHEA:22436"
              ],
              "previous": [
                "EC:4.2.3.22",
                "KEGG_REACTION:R07647",
                "MetaCyc:RXN-8648",
                "RHEA:22436"
              ]
            }
          }
        },
        {
          "id": "GO:0034022",
          "name": "3-(hydroxyamino)phenol mutase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.4.4.3",
                "KEGG_REACTION:R06988",
                "MetaCyc:5.4.4.3-RXN",
                "RHEA:20577",
                "UM-BBD_enzymeID:r1496"
              ],
              "previous": [
                "EC:5.4.4.3",
                "KEGG_REACTION:R06988",
                "MetaCyc:5.4.4.3-RXN",
                "RHEA:20577",
                "UM-BBD_enzymeID:e0953"
              ]
            }
          }
        },
        {
          "id": "GO:0034061",
          "name": "DNA polymerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:22508"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0034317",
          "name": "nicotinate riboside kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.173",
                "MetaCyc:RXN-8443",
                "RHEA:25568"
              ],
              "previous": [
                "MetaCyc:RXN-8443"
              ]
            }
          }
        },
        {
          "id": "GO:0034386",
          "name": "4-aminobutyrate:2-oxoglutarate transaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.6.1.19",
                "MetaCyc:GABATRANSAM-RXN",
                "RHEA:23352"
              ],
              "previous": [
                "EC:2.6.1.19",
                "MetaCyc:GABATRANSAM-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0034601",
          "name": "oxoglutarate dehydrogenase [NAD(P)+] activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:1.2.1.52"
              ]
            }
          }
        },
        {
          "id": "GO:0034701",
          "name": "tripeptidase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:3.4.11.4-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0034824",
          "name": "citronellyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "UM-BBD_reactionID:r1159"
              ]
            }
          }
        },
        {
          "id": "GO:0034832",
          "name": "geranial dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "UM-BBD_reactionID:r1164"
              ]
            }
          }
        },
        {
          "id": "GO:0035446",
          "name": "cysteine-glucosaminylinositol ligase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.3.1.13",
                "MetaCyc:RXN1G-121",
                "RHEA:26176"
              ],
              "previous": [
                "EC:6.3.1.13",
                "MetaCyc:RXN1G-4",
                "RHEA:26176"
              ]
            }
          }
        },
        {
          "id": "GO:0035888",
          "name": "isoguanine deaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN0-6708",
                "RHEA:47720"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0036239",
          "name": "taxoid 7beta-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.182",
                "KEGG_REACTION:R09868"
              ],
              "previous": [
                "EC:1.14.14.182",
                "KEGG_REACTION:R09868",
                "MetaCyc:RXN-12885"
              ]
            }
          }
        },
        {
          "id": "GO:0036311",
          "name": "chitin disaccharide deacetylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.1.105",
                "MetaCyc:RXN-11313",
                "RHEA:27469"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0043136",
          "name": "glycerol-3-phosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.3.21",
                "MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN",
                "Reactome:R-HSA-8955794 \"PGP:Mg2+ dimer hydrolyses 3PG to glycerol\"",
                "RHEA:66372"
              ],
              "previous": [
                "MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN",
                "Reactome:R-HSA-8955794 \"PGP:Mg2+ dimer hydrolyses 3PG to glycerol\""
              ]
            }
          }
        },
        {
          "id": "GO:0043748",
          "name": "O-succinylbenzoate synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.113",
                "RHEA:10196"
              ],
              "previous": [
                "EC:4.2.1.113"
              ]
            }
          }
        },
        {
          "id": "GO:0043770",
          "name": "demethylmenaquinone methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.163",
                "MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN",
                "MetaCyc:RXN-11046",
                "MetaCyc:RXN-9191"
              ],
              "previous": [
                "EC:2.1.1.163"
              ]
            }
          }
        },
        {
          "id": "GO:0043793",
          "name": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.2.54"
              ],
              "previous": [
                "MetaCyc:RXN-8124"
              ]
            }
          }
        },
        {
          "id": "GO:0043794",
          "name": "formate dehydrogenase (coenzyme F420) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.17.98.3",
                "MetaCyc:RXN-15617",
                "RHEA:42764"
              ],
              "previous": [
                "EC:1.2.99.-"
              ]
            }
          }
        },
        {
          "id": "GO:0043817",
          "name": "phosphosulfolactate synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.4.1.19",
                "KEGG_REACTION:R07476",
                "MetaCyc:4.4.1.19-RXN",
                "RHEA:22784"
              ],
              "previous": [
                "EC:4.4.1.19",
                "KEGG_REACTION:R07476",
                "MetaCyc:ABC-16-RXN",
                "RHEA:22784"
              ]
            }
          }
        },
        {
          "id": "GO:0043842",
          "name": "Kdo transferase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:2.4.99.12",
                "EC:2.4.99.13",
                "EC:2.4.99.14",
                "EC:2.4.99.15",
                "MetaCyc:KDOTRANS-RXN",
                "MetaCyc:KDOTRANS2-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0043860",
          "name": "cyanophycin synthetase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:6.3.1.-"
              ]
            }
          }
        },
        {
          "id": "GO:0043876",
          "name": "D-threonine aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.2.42",
                "MetaCyc:4.1.2.42-RXN"
              ],
              "previous": [
                "EC:4.1.2.42",
                "MetaCyc:4.1.2.42-RXN",
                "RHEA:15257"
              ]
            }
          }
        },
        {
          "id": "GO:0043883",
          "name": "malolactic enzyme activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.1.101",
                "MetaCyc:RXN-16819",
                "RHEA:46277"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0043916",
          "name": "DNA-7-methylguanine glycosylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.2.21"
              ],
              "previous": [
                "EC:3.2.2.21",
                "MetaCyc:3.2.2.21-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0043959",
          "name": "L-erythro-3-methylmalyl-CoA lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.3.24",
                "RHEA:38259"
              ],
              "previous": [
                "EC:4.1.3.24"
              ]
            }
          }
        },
        {
          "id": "GO:0044024",
          "name": "histone H2AS1 kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.11.1"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0044540",
          "name": "L-cystine L-cysteine-lyase (deaminating)",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.4.1.1",
                "EC:4.4.1.35",
                "KEGG_REACTION:R02408",
                "RHEA:24927"
              ],
              "previous": [
                "EC:4.4.1.1",
                "KEGG_REACTION:R02408",
                "RHEA:24927"
              ]
            }
          }
        },
        {
          "id": "GO:0045486",
          "name": "flavanone 3-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.11.9",
                "MetaCyc:1.14.11.9-RXN",
                "RHEA:18621"
              ],
              "previous": [
                "EC:1.14.11.9",
                "MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN",
                "RHEA:18621"
              ]
            }
          }
        },
        {
          "id": "GO:0046353",
          "name": "aminoglycoside 3-N-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.81",
                "MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN",
                "RHEA:12665"
              ],
              "previous": [
                "EC:2.3.1.60",
                "EC:2.3.1.81",
                "MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN",
                "MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0046428",
          "name": "1,4-dihydroxy-2-naphthoate polyprenyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.5.1.74",
                "MetaCyc:RXN-11047",
                "RHEA:26478"
              ],
              "previous": [
                "EC:2.5.1.74",
                "MetaCyc:DMK-RXN",
                "RHEA:30099"
              ]
            }
          }
        },
        {
          "id": "GO:0046592",
          "name": "polyamine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.3.17"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0046857",
          "name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.7.1.-"
              ],
              "previous": [
                "EC:1.7.1.-",
                "UM-BBD_enzymeID:e0346"
              ]
            }
          }
        },
        {
          "id": "GO:0046961",
          "name": "proton-transporting ATPase activity, rotational mechanism",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:ATPSYN-RXN",
                "RHEA:57721"
              ],
              "previous": [
                "RHEA:57721"
              ]
            }
          }
        },
        {
          "id": "GO:0046976",
          "name": "histone H3K27 methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "Reactome:R-HSA-3240295 \"PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter\""
              ],
              "previous": [
                "EC:2.1.1.356",
                "Reactome:R-HSA-3240295 \"PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter\""
              ]
            }
          }
        },
        {
          "id": "GO:0047026",
          "name": "androsterone dehydrogenase (A-specific) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.213",
                "MetaCyc:1.1.1.209-RXN",
                "Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)"
              ],
              "previous": [
                "EC:1.1.1.213",
                "MetaCyc:1.1.1.213-RXN",
                "Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)"
              ]
            }
          }
        },
        {
          "id": "GO:0047196",
          "name": "long-chain-alcohol O-fatty-acyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.75",
                "MetaCyc:2.3.1.75-RXN",
                "MetaCyc:RXNQT-4193",
                "Reactome:R-HSA-5696424 \"AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters\"",
                "Reactome:R-HSA-8848582 \"AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester\"",
                "RHEA:38443"
              ],
              "previous": [
                "EC:2.3.1.75",
                "MetaCyc:2.3.1.75-RXN",
                "MetaCyc:RXN-9356",
                "MetaCyc:RXNQT-4193",
                "Reactome:R-HSA-5696424 \"AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters\"",
                "Reactome:R-HSA-8848582 \"AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester\"",
                "RHEA:38443"
              ]
            }
          }
        },
        {
          "id": "GO:0047224",
          "name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.147",
                "MetaCyc:2.4.1.147-RXN"
              ],
              "previous": [
                "EC:2.4.1.147",
                "MetaCyc:2.4.1.147-RXN",
                "RHEA:46884 {comment=\"skos:narrowMatch\"}"
              ]
            }
          }
        },
        {
          "id": "GO:0047264",
          "name": "heteroglycan alpha-mannosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.48",
                "KEGG_REACTION:R03768",
                "KEGG_REACTION:R03769",
                "MetaCyc:2.4.1.48-RXN",
                "MetaCyc:RXN-7992"
              ],
              "previous": [
                "EC:2.4.1.48"
              ]
            }
          }
        },
        {
          "id": "GO:0047270",
          "name": "lipopolysaccharide glucosyltransferase II activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.73",
                "MetaCyc:RXN0-5125",
                "RHEA:30003"
              ],
              "previous": [
                "EC:2.4.1.73",
                "MetaCyc:RXN0-5125"
              ]
            }
          }
        },
        {
          "id": "GO:0047322",
          "name": "[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.11.31",
                "MetaCyc:2.7.1.109-RXN"
              ],
              "previous": [
                "EC:2.7.11.27",
                "EC:2.7.11.31",
                "MetaCyc:2.7.1.109-RXN",
                "MetaCyc:2.7.11.27-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0047325",
          "name": "inositol-3,4,5,6-tetrakisphosphate 1-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.134",
                "KEGG_REACTION:R03479",
                "MetaCyc:2.7.1.134-RXN",
                "Reactome:R-HSA-1855162 \"I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol\"",
                "Reactome:R-HSA-994137 \"ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5\"",
                "RHEA:12452"
              ],
              "previous": [
                "EC:2.7.1.134",
                "MetaCyc:2.7.1.134-RXN",
                "Reactome:R-HSA-1855162 \"I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol\"",
                "Reactome:R-HSA-994137 \"ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5\"",
                "RHEA:12452"
              ]
            }
          }
        },
        {
          "id": "GO:0047326",
          "name": "inositol-1,3,4,6-tetrakisphosphate 5-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.140",
                "EC:2.7.1.151",
                "KEGG_REACTION:R03478",
                "MetaCyc:2.7.1.140-RXN",
                "Reactome:R-HSA-1855228 \"I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\"",
                "RHEA:12717"
              ],
              "previous": [
                "EC:2.7.1.140",
                "MetaCyc:2.7.1.140-RXN",
                "Reactome:R-HSA-1855228 \"I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus\"",
                "RHEA:12717"
              ]
            }
          }
        },
        {
          "id": "GO:0047372",
          "name": "monoacylglycerol lipase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.23",
                "EC:3.1.1.79",
                "MetaCyc:RXN-19280",
                "Reactome:R-HSA-1482543 \"2-MAG is hydrolyzed to fatty acid and glycerol by MGLL\"",
                "Reactome:R-HSA-163595 \"2-acylglycerol + H2O -> glycerol + fatty acid\"",
                "Reactome:R-HSA-192422 \"Digestion of triacylglycerols by extracellular PTL:colipase\"",
                "Reactome:R-HSA-192425 \"Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)\"",
                "Reactome:R-HSA-192430 \"Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)\"",
                "Reactome:R-HSA-192434 \"Digestion of diacylglycerols by extracellular PTL:colipase\"",
                "Reactome:R-HSA-192475 \"Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2\"",
                "Reactome:R-HSA-426032 \"DAG is metabolized by DAGL to 2-AG\"",
                "Reactome:R-HSA-426043 \"2-AG hydrolysis to arachidonate by MAGL\"",
                "Reactome:R-HSA-5694462 \"ABHD6,12 hydrolyse 3AG\"",
                "RHEA:15245"
              ],
              "previous": [
                "EC:3.1.1.23",
                "MetaCyc:3.1.1.23-RXN",
                "Reactome:R-HSA-1482543 \"2-MAG is hydrolyzed to fatty acid and glycerol by MGLL\"",
                "Reactome:R-HSA-163595 \"2-acylglycerol + H2O -> glycerol + fatty acid\"",
                "Reactome:R-HSA-192422 \"Digestion of triacylglycerols by extracellular PTL:colipase\"",
                "Reactome:R-HSA-192425 \"Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)\"",
                "Reactome:R-HSA-192430 \"Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)\"",
                "Reactome:R-HSA-192434 \"Digestion of diacylglycerols by extracellular PTL:colipase\"",
                "Reactome:R-HSA-192475 \"Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2\"",
                "Reactome:R-HSA-426032 \"DAG is metabolized by DAGL to 2-AG\"",
                "Reactome:R-HSA-426043 \"2-AG hydrolysis to arachidonate by MAGL\"",
                "Reactome:R-HSA-5694462 \"ABHD6,12 hydrolyse 3AG\"",
                "RHEA:34019"
              ]
            }
          }
        },
        {
          "id": "GO:0047443",
          "name": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.3.17",
                "MetaCyc:4.1.3.17-RXN"
              ],
              "previous": [
                "EC:4.1.3.17",
                "MetaCyc:4.1.3.17-RXN",
                "RHEA:22748"
              ]
            }
          }
        },
        {
          "id": "GO:0047453",
          "name": "ATP-dependent NAD(P)H-hydrate dehydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.93",
                "KEGG_REACTION:R00129",
                "MetaCyc:4.2.1.93-RXN",
                "Reactome:R-HSA-6806967 \"CARKD dehydrates S-NAD(P)HX to NADPH\""
              ],
              "previous": [
                "EC:4.2.1.93",
                "KEGG_REACTION:R00129",
                "MetaCyc:4.2.1.93-RXN",
                "Reactome:R-HSA-6806967 \"CARKD dehydrates S-NAD(P)HX to NADPH\"",
                "RHEA:19017"
              ]
            }
          }
        },
        {
          "id": "GO:0047508",
          "name": "(R)-2-methylmalate dehydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.35",
                "KEGG_REACTION:R03896"
              ],
              "previous": [
                "EC:4.2.1.35",
                "KEGG_REACTION:R03896",
                "MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN",
                "RHEA:22332"
              ]
            }
          }
        },
        {
          "id": "GO:0047522",
          "name": "15-oxoprostaglandin 13-oxidase [NAD(P)+] activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.48",
                "MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN",
                "Reactome:R-HSA-2161692 \"15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1\""
              ],
              "previous": [
                "EC:1.3.1.48",
                "KEGG_REACTION:R04556",
                "KEGG_REACTION:R04557",
                "MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0047562",
          "name": "3-hydroxyaspartate aldolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.3.14",
                "KEGG_REACTION:R00478",
                "MetaCyc:RXN-11769",
                "RHEA:14377"
              ],
              "previous": [
                "EC:4.1.3.14",
                "KEGG_REACTION:R00478",
                "MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN",
                "RHEA:14377"
              ]
            }
          }
        },
        {
          "id": "GO:0047571",
          "name": "3-oxosteroid 1-dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.99.4",
                "MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN",
                "RHEA:13329"
              ],
              "previous": [
                "EC:1.3.99.4",
                "MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN",
                "RHEA:13329",
                "UM-BBD_enzymeID:e0712"
              ]
            }
          }
        },
        {
          "id": "GO:0047606",
          "name": "(S)-hydroxynitrile lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.2.47"
              ],
              "previous": [
                "EC:4.1.2.47",
                "MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0047617",
          "name": "fatty acyl-CoA hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.2.20",
                "MetaCyc:ACYL-COA-HYDROLASE-RXN",
                "Reactome:R-HSA-5690042 \"Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA\"",
                "Reactome:R-HSA-5690043 \"Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA\"",
                "Reactome:R-HSA-5690066 \"ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA\"",
                "RHEA:16781"
              ],
              "previous": [
                "EC:3.1.2.20",
                "EC:3.1.2.3",
                "MetaCyc:ACYL-COA-HYDROLASE-RXN",
                "Reactome:R-HSA-5690042 \"Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA\"",
                "Reactome:R-HSA-5690043 \"Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA\"",
                "Reactome:R-HSA-5690066 \"ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA\"",
                "RHEA:16781"
              ]
            }
          }
        },
        {
          "id": "GO:0047748",
          "name": "cholestanetetraol 26-dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.15.15",
                "MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN",
                "MetaCyc:RXN-13690",
                "RHEA:34631"
              ],
              "previous": [
                "EC:1.14.15.15",
                "MetaCyc:1.2.1.40-RXN",
                "MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN",
                "MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN",
                "RHEA:34631"
              ]
            }
          }
        },
        {
          "id": "GO:0047751",
          "name": "3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.22",
                "KEGG_REACTION:R02610",
                "MetaCyc:1.3.99.5-RXN",
                "RHEA:54384"
              ],
              "previous": [
                "EC:1.3.1.22",
                "EC:1.3.1.30",
                "KEGG_REACTION:R02610",
                "MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN",
                "MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN",
                "MetaCyc:RXN-4229",
                "MetaCyc:RXN-711",
                "RHEA:54384"
              ]
            }
          }
        },
        {
          "id": "GO:0047804",
          "name": "cysteine-S-conjugate beta-lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.4.1.13",
                "MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN",
                "MetaCyc:RXN-6763",
                "RHEA:18121"
              ],
              "previous": [
                "EC:4.4.1.13",
                "EC:4.4.1.6",
                "MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN",
                "MetaCyc:RXN-6763",
                "MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN",
                "RHEA:18121"
              ]
            }
          }
        },
        {
          "id": "GO:0047806",
          "name": "cytochrome-c3 hydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.12.2.1",
                "MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN",
                "RHEA:20625"
              ],
              "previous": [
                "EC:1.12.2.1",
                "MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN",
                "RHEA:20625",
                "UM-BBD_enzymeID:e0481"
              ]
            }
          }
        },
        {
          "id": "GO:0047847",
          "name": "deoxyuridine phosphorylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.2.2",
                "EC:2.4.2.3",
                "MetaCyc:URA-PHOSPH-RXN",
                "RHEA:22824"
              ],
              "previous": [
                "MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN",
                "RHEA:22824"
              ]
            }
          }
        },
        {
          "id": "GO:0047849",
          "name": "dextransucrase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.125",
                "EC:2.4.1.140",
                "EC:2.4.1.5",
                "MetaCyc:2.4.1.125-RXN",
                "MetaCyc:2.4.1.140-RXN",
                "RHEA:18825"
              ],
              "previous": [
                "EC:2.4.1.5",
                "MetaCyc:2.4.1.125-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0047880",
          "name": "erythrulose reductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.162",
                "KEGG_REACTION:R08573",
                "MetaCyc:RXN-17773",
                "RHEA:18005"
              ],
              "previous": [
                "EC:1.1.1.162",
                "KEGG_REACTION:R08573",
                "MetaCyc:ERYTHRULOSE-REDUCTASE-RXN",
                "RHEA:18005"
              ]
            }
          }
        },
        {
          "id": "GO:0047991",
          "name": "hydroxylamine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.7.3.6",
                "KEGG_REACTION:R00793",
                "MetaCyc:RXN-13595",
                "RHEA:19969"
              ],
              "previous": [
                "EC:1.7.3.6",
                "KEGG_REACTION:R00793",
                "MetaCyc:HAONITRO-RXN",
                "RHEA:19969"
              ]
            }
          }
        },
        {
          "id": "GO:0047995",
          "name": "hydroxyphenylpyruvate reductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.237",
                "MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN",
                "RHEA:10780"
              ],
              "previous": [
                "EC:1.1.1.237",
                "MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN",
                "MetaCyc:RXN-7632",
                "RHEA:10780"
              ]
            }
          }
        },
        {
          "id": "GO:0050040",
          "name": "lactate 2-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.12.4",
                "KEGG_REACTION:R00319",
                "MetaCyc:RXN-19631",
                "RHEA:16513"
              ],
              "previous": [
                "EC:1.13.12.4",
                "KEGG_REACTION:R00319",
                "MetaCyc:LACTATE-2-MONOOXYGENASE-RXN",
                "RHEA:16513"
              ]
            }
          }
        },
        {
          "id": "GO:0050079",
          "name": "acetylenecarboxylate hydratase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.1.27",
                "MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN",
                "MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN",
                "RHEA:17957"
              ],
              "previous": [
                "EC:4.2.1.27",
                "MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN",
                "RHEA:17957"
              ]
            }
          }
        },
        {
          "id": "GO:0050138",
          "name": "nicotinate dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.17.1.5",
                "KEGG_REACTION:R01720",
                "MetaCyc:RXN-7637",
                "RHEA:12236"
              ],
              "previous": [
                "EC:1.17.1.5",
                "KEGG_REACTION:R01720",
                "MetaCyc:NICOTINATE-DEHYDROGENASE-RXN",
                "MetaCyc:RXN-7637",
                "RHEA:12236"
              ]
            }
          }
        },
        {
          "id": "GO:0050183",
          "name": "phosphatidylcholine 12-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.18.4",
                "KEGG_REACTION:R03476",
                "MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN",
                "RHEA:46360"
              ],
              "previous": [
                "EC:1.14.18.4",
                "KEGG_REACTION:R03476",
                "MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN",
                "MetaCyc:RXN-14488",
                "RHEA:46360"
              ]
            }
          }
        },
        {
          "id": "GO:0050450",
          "name": "citrate (Re)-synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.3.3"
              ],
              "previous": [
                "EC:2.3.3.3",
                "MetaCyc:CITSYN-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0050470",
          "name": "trimethylamine dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.8.2",
                "MetaCyc:1.5.8.2-RXN",
                "RHEA:11864",
                "UM-BBD_enzymeID:r1378"
              ],
              "previous": [
                "EC:1.5.8.2",
                "MetaCyc:1.5.8.2-RXN",
                "RHEA:11864",
                "UM-BBD_enzymeID:e0854"
              ]
            }
          }
        },
        {
          "id": "GO:0050547",
          "name": "feruloyl-CoA hydratase/lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.2.61",
                "KEGG_REACTION:R12566",
                "MetaCyc:RXN-21004",
                "RHEA:62412"
              ],
              "previous": [
                "EC:4.1.2.61",
                "EC:4.2.1.101",
                "KEGG_REACTION:R12566",
                "MetaCyc:4.2.1.101-RXN",
                "MetaCyc:RXN-21004",
                "RHEA:62412"
              ]
            }
          }
        },
        {
          "id": "GO:0050550",
          "name": "pinene synthase activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "RHEA:25496 {xref=\"skos:narrowMatch\"}"
              ]
            }
          }
        },
        {
          "id": "GO:0050555",
          "name": "2-hydroxypropyl-CoM lyase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.4.1.23",
                "MetaCyc:4.2.99.19-RXN",
                "UM-BBD_enzymeID:r0851",
                "UM-BBD_enzymeID:r0858"
              ],
              "previous": [
                "EC:4.4.1.23",
                "MetaCyc:4.2.99.19-RXN",
                "UM-BBD_enzymeID:e0538"
              ]
            }
          }
        },
        {
          "id": "GO:0050563",
          "name": "trans-feruloyl-CoA synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:6.2.1.34",
                "MetaCyc:6.2.1.34-RXN"
              ],
              "previous": [
                "EC:6.2.1.34",
                "MetaCyc:6.2.1.34-RXN",
                "RHEA:19389"
              ]
            }
          }
        },
        {
          "id": "GO:0050697",
          "name": "trichloroethene reductive dehalogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:TCEREDCHLOR-RXN",
                "RHEA:67992",
                "UM-BBD_enzymeID:r0350",
                "UM-BBD_enzymeID:r0932"
              ],
              "previous": [
                "MetaCyc:TCEREDCHLOR-RXN",
                "UM-BBD_enzymeID:e0271"
              ]
            }
          }
        },
        {
          "id": "GO:0051269",
          "name": "alpha-ketoester reductase (NADPH) activity",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "EC:1.2.-.-"
              ]
            }
          }
        },
        {
          "id": "GO:0051698",
          "name": "saccharopine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.3.18",
                "RHEA:28210"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0051717",
          "name": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:3.1.3.62-RXN",
                "Reactome:R-HSA-1855200 \"I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen\"",
                "Reactome:R-HSA-1855205 \"I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol\"",
                "RHEA:77155"
              ],
              "previous": [
                "MetaCyc:3.1.3.62-RXN",
                "Reactome:R-HSA-1855200 \"I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen\"",
                "Reactome:R-HSA-1855205 \"I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol\""
              ]
            }
          }
        },
        {
          "id": "GO:0052577",
          "name": "germacrene-D synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.2.3.22",
                "EC:4.2.3.75",
                "KEGG_REACTION:R07648",
                "MetaCyc:RXN-8562",
                "RHEA:12016"
              ],
              "previous": [
                "EC:4.2.3.22",
                "KEGG_REACTION:R07648",
                "MetaCyc:RXN-8562",
                "RHEA:12016"
              ]
            }
          }
        },
        {
          "id": "GO:0052579",
          "name": "(+)-pulegone reductase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.1.81"
              ],
              "previous": [
                "EC:1.3.1.81",
                "MetaCyc:RXN-5164"
              ]
            }
          }
        },
        {
          "id": "GO:0052601",
          "name": "limonene 1,2-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.13.107"
              ],
              "previous": [
                "EC:1.14.13.107",
                "UM-BBD_enzymeID:e0462"
              ]
            }
          }
        },
        {
          "id": "GO:0052615",
          "name": "ent-kaurene oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.86",
                "MetaCyc:1.14.13.78-RXN",
                "MetaCyc:RXN-7580",
                "RHEA:32323"
              ],
              "previous": [
                "EC:1.14.14.86",
                "MetaCyc:1.14.13.78-RXN",
                "MetaCyc:RXN-5242",
                "MetaCyc:RXN-7580",
                "RHEA:32323"
              ]
            }
          }
        },
        {
          "id": "GO:0052624",
          "name": "2-phytyl-1,4-naphthoquinone methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.329",
                "KEGG_REACTION:R06859",
                "MetaCyc:RXN-7569",
                "RHEA:40551"
              ],
              "previous": [
                "KEGG_REACTION:R06859",
                "MetaCyc:RXN-6723",
                "MetaCyc:RXN-7569"
              ]
            }
          }
        },
        {
          "id": "GO:0052625",
          "name": "N-(4-aminobenzoyl)-L-glutamate synthetase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10884"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052626",
          "name": "N-benzoyl-L-glutamate synthetase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10886"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052627",
          "name": "N-vanillate-L-glutamate synthetase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10885"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052628",
          "name": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10887"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052664",
          "name": "nitroalkane oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.7.3.1"
              ],
              "previous": [
                "EC:1.7.3.1",
                "KEGG_REACTION:R00799",
                "MetaCyc:RXN-11045"
              ]
            }
          }
        },
        {
          "id": "GO:0052706",
          "name": "L-histidine N(alpha)-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.44",
                "KEGG_REACTION:R01169",
                "MetaCyc:RXN-14431",
                "RHEA:38471"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052724",
          "name": "inositol hexakisphosphate 3-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10971"
              ],
              "previous": [
                "EC:2.7.4.21",
                "MetaCyc:RXN-10971"
              ]
            }
          }
        },
        {
          "id": "GO:0052725",
          "name": "inositol-1,3,4-trisphosphate 6-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.159",
                "KEGG_REACTION:R03429",
                "MetaCyc:2.7.1.133-RXN",
                "Reactome:R-HSA-1855197 \"I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol\"",
                "Reactome:R-HSA-2267372 \"ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4\"",
                "RHEA:20940"
              ],
              "previous": [
                "EC:2.7.1.159",
                "MetaCyc:2.7.1.133-RXN",
                "Reactome:R-HSA-1855197 \"I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol\"",
                "Reactome:R-HSA-2267372 \"ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4\"",
                "RHEA:20940"
              ]
            }
          }
        },
        {
          "id": "GO:0052741",
          "name": "(R)-limonene 6-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.53",
                "KEGG_REACTION:R06119",
                "MetaCyc:RXN-10746",
                "RHEA:18957"
              ],
              "previous": [
                "EC:1.14.14.53",
                "KEGG_REACTION:R06119",
                "MetaCyc:1.14.13.84-RXN",
                "RHEA:18957"
              ]
            }
          }
        },
        {
          "id": "GO:0052754",
          "name": "GTP:coenzyme F420 guanyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-18273"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0052773",
          "name": "diacetylchitobiose deacetylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.5.1.136",
                "MetaCyc:RXN-12543",
                "RHEA:62168"
              ],
              "previous": [
                "MetaCyc:RXN-12543"
              ]
            }
          }
        },
        {
          "id": "GO:0052811",
          "name": "1-phosphatidylinositol-3-phosphate 4-kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10957",
                "Reactome:R-HSA-1676145 \"PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane\"",
                "RHEA:63688"
              ],
              "previous": [
                "Reactome:R-HSA-1676145 \"PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane\"",
                "RHEA:63688"
              ]
            }
          }
        },
        {
          "id": "GO:0052821",
          "name": "DNA-7-methyladenine glycosylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.2.21"
              ],
              "previous": [
                "EC:3.2.2.21",
                "MetaCyc:3.2.2.21-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0052822",
          "name": "DNA-3-methylguanine glycosylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.2.21"
              ],
              "previous": [
                "EC:3.2.2.21",
                "MetaCyc:3.2.2.21-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0052903",
          "name": "N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.3.13",
                "KEGG_REACTION:R03899",
                "MetaCyc:RXN-12090",
                "MetaCyc:RXN-9940",
                "RHEA:25800"
              ],
              "previous": [
                "EC:1.5.3.13",
                "EC:1.5.3.17",
                "KEGG_REACTION:R03899",
                "MetaCyc:RXN-12090",
                "MetaCyc:RXN-9940",
                "RHEA:25800"
              ]
            }
          }
        },
        {
          "id": "GO:0052904",
          "name": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.5.3.13",
                "KEGG_REACTION:R09074",
                "MetaCyc:RXN-12091",
                "Reactome:R-HSA-141348 \"PAO:FAD oxidises NASPM to PTCN\"",
                "Reactome:R-HSA-141351 \"PAOX:FAD oxidises NASPN to SPM\"",
                "RHEA:25812"
              ],
              "previous": [
                "EC:1.5.3.13",
                "EC:1.5.3.17",
                "KEGG_REACTION:R09074",
                "MetaCyc:RXN-12091",
                "Reactome:R-HSA-141348 \"PAO:FAD oxidises NASPM to PTCN\"",
                "Reactome:R-HSA-141351 \"PAOX:FAD oxidises NASPN to SPM\"",
                "RHEA:25812"
              ]
            }
          }
        },
        {
          "id": "GO:0052934",
          "name": "alcohol dehydrogenase (cytochrome c) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.2.8",
                "KEGG_REACTION:R05198",
                "KEGG_REACTION:R05285",
                "MetaCyc:RXN-11333",
                "RHEA:51020"
              ],
              "previous": [
                "EC:1.1.2.8",
                "KEGG_REACTION:R05198",
                "KEGG_REACTION:R05285",
                "MetaCyc:RXN-11333",
                "RHEA:51020",
                "UM-BBD_enzymeID:e0004"
              ]
            }
          }
        },
        {
          "id": "GO:0061990",
          "name": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.207",
                "MetaCyc:RXN-13613",
                "RHEA:42264"
              ],
              "previous": [
                "MetaCyc:RXN-13613",
                "RHEA:42264"
              ]
            }
          }
        },
        {
          "id": "GO:0062193",
          "name": "D-ribose pyranase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.4.99.62"
              ],
              "previous": [
                "EC:5.4.99.62",
                "RHEA:25432"
              ]
            }
          }
        },
        {
          "id": "GO:0070040",
          "name": "rRNA (adenine(2503)-C2-)-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.192",
                "MetaCyc:RXN-11586",
                "RHEA:42916"
              ],
              "previous": [
                "EC:2.1.1.192",
                "MetaCyc:RXN-11586",
                "MetaCyc:RXN0-7007",
                "RHEA:42916"
              ]
            }
          }
        },
        {
          "id": "GO:0070330",
          "name": "aromatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.14",
                "UM-BBD_reactionID:r1132",
                "UM-BBD_reactionID:r1137"
              ],
              "previous": [
                "EC:1.14.14.1",
                "MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN",
                "RHEA:17149",
                "UM-BBD_enzymeID:e0551"
              ]
            }
          }
        },
        {
          "id": "GO:0070524",
          "name": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.1.146",
                "MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN",
                "Reactome:R-HSA-9757706 \"HSD11B1 hydrogenates PREDN to PREDL in hepatic cell\"",
                "Reactome:R-HSA-9759259 \"HSD11B2 dehydrogenates PREDL to PREDN\"",
                "RHEA:11388",
                "Wikipedia:11beta-hydroxysteroid_dehydrogenase"
              ],
              "previous": [
                "EC:1.1.1.146",
                "Reactome:R-HSA-9757706 \"HSD11B1 hydrogenates PREDN to PREDL in hepatic cell\"",
                "Reactome:R-HSA-9759259 \"HSD11B2 dehydrogenates PREDL to PREDN\"",
                "RHEA:11388",
                "Wikipedia:11beta-hydroxysteroid_dehydrogenase"
              ]
            }
          }
        },
        {
          "id": "GO:0070780",
          "name": "dihydrosphingosine-1-phosphate phosphatase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:DHS-PHOSPHATASE-RXN",
                "Reactome:R-HSA-428664 \"SGPP1,2 dephosphorylate sphingoid-1-phosphates\"",
                "RHEA:27514"
              ],
              "previous": [
                "MetaCyc:RXN3DJ-25",
                "Reactome:R-HSA-428664 \"SGPP1,2 dephosphorylate sphingoid-1-phosphates\"",
                "RHEA:27514"
              ]
            }
          }
        },
        {
          "id": "GO:0070991",
          "name": "medium-chain fatty acyl-CoA dehydrogenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.8.7",
                "MetaCyc:RXN-11734",
                "RHEA:14477"
              ],
              "previous": [
                "EC:1.3.8.7",
                "RHEA:14477"
              ]
            }
          }
        },
        {
          "id": "GO:0072374",
          "name": "carotene epsilon hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.158"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0080030",
          "name": "methyl indole-3-acetate esterase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10711",
                "RHEA:32919"
              ],
              "previous": [
                "MetaCyc:RXN-10711"
              ]
            }
          }
        },
        {
          "id": "GO:0080031",
          "name": "methyl salicylate esterase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXNQT-4366",
                "RHEA:33611"
              ],
              "previous": [
                "MetaCyc:RXNQT-4366"
              ]
            }
          }
        },
        {
          "id": "GO:0080032",
          "name": "methyl jasmonate esterase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-10767",
                "RHEA:55372"
              ],
              "previous": [
                "MetaCyc:RXN-10767"
              ]
            }
          }
        },
        {
          "id": "GO:0080131",
          "name": "hydroxyjasmonate sulfotransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.8.2.39",
                "MetaCyc:RXN-10451"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0089702",
          "name": "undecaprenyl-phosphate glucose phosphotransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.8.31",
                "RHEA:28126"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0090439",
          "name": "tetraketide alpha-pyrone synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-16407"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0090471",
          "name": "9,15,9'-tri-cis-zeta-carotene isomerase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:5.2.1.12",
                "MetaCyc:RXN-11354",
                "RHEA:30967"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0090499",
          "name": "pimelyl-[acyl-carrier protein] methyl ester esterase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.85",
                "MetaCyc:RXN-11483",
                "RHEA:42700"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0090595",
          "name": "acetyl-CoA:L-lysine N6-acetyltransferase",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.306",
                "MetaCyc:LYSACET-RXN",
                "RHEA:69476"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0090710",
          "name": "phosphomevalonate decarboxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:4.1.1.99",
                "MetaCyc:RXN-10067",
                "RHEA:40955"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0102009",
          "name": "proline dipeptidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.4.13.9",
                "MetaCyc:3.4.13.9-RXN",
                "RHEA:76407"
              ],
              "previous": [
                "EC:3.4.13.9",
                "MetaCyc:3.4.13.9-RXN"
              ]
            }
          }
        },
        {
          "id": "GO:0102014",
          "name": "beta-D-galactose-importing ATPase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:30011"
              ],
              "previous": [
                "MetaCyc:ABC-18-RXN",
                "RHEA:30011"
              ]
            }
          }
        },
        {
          "id": "GO:0102097",
          "name": "22alpha-hydroxysteroid 23-monooxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.147",
                "MetaCyc:RXN-11101"
              ],
              "previous": [
                "EC:1.14.14.147",
                "MetaCyc:RXN-11101",
                "MetaCyc:RXN-11531"
              ]
            }
          }
        },
        {
          "id": "GO:0102103",
          "name": "demethoxycurcumin synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.219"
              ],
              "previous": [
                "EC:2.3.1.219",
                "MetaCyc:RXN-11223",
                "RHEA:35119"
              ]
            }
          }
        },
        {
          "id": "GO:0102223",
          "name": "4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.3.8.2",
                "MetaCyc:RXN-12224",
                "RHEA:31391"
              ],
              "previous": [
                "EC:1.3.8.2",
                "MetaCyc:RXN-12224",
                "MetaCyc:RXN-12258",
                "RHEA:31391",
                "RHEA:42800"
              ]
            }
          }
        },
        {
          "id": "GO:0102237",
          "name": "ATP:farnesol kinase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.7.1.216",
                "MetaCyc:RXN-12304",
                "RHEA:61656"
              ],
              "previous": [
                "MetaCyc:RXN-12304",
                "RHEA:61656"
              ]
            }
          }
        },
        {
          "id": "GO:0102244",
          "name": "3-aminopropanal dehydrogenase (NAD+) activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-12332",
                "RHEA:30695"
              ],
              "previous": [
                "MetaCyc:RXN-12332"
              ]
            }
          }
        },
        {
          "id": "GO:0102289",
          "name": "beta-amyrin 11-oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.152",
                "MetaCyc:RXN-12680",
                "MetaCyc:RXN-12682",
                "RHEA:31711"
              ],
              "previous": [
                "EC:1.14.14.152",
                "MetaCyc:RXN-12680",
                "MetaCyc:RXN-12681",
                "MetaCyc:RXN-12682",
                "RHEA:31711"
              ]
            }
          }
        },
        {
          "id": "GO:0102307",
          "name": "erythromycin 3''-o-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.254"
              ],
              "previous": [
                "EC:2.1.1.254",
                "MetaCyc:RXN-12923",
                "RHEA:32647"
              ]
            }
          }
        },
        {
          "id": "GO:0102358",
          "name": "daphnetin-8-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13448",
                "RHEA:68960"
              ],
              "previous": [
                "MetaCyc:RXN-13448"
              ]
            }
          }
        },
        {
          "id": "GO:0102365",
          "name": "taxoid 2alpha-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.183",
                "MetaCyc:RXN-13486",
                "MetaCyc:RXN-13487"
              ],
              "previous": [
                "MetaCyc:RXN-13486"
              ]
            }
          }
        },
        {
          "id": "GO:0102377",
          "name": "steviol 13-O glucosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13511",
                "RHEA:61732"
              ],
              "previous": [
                "MetaCyc:RXN-13511"
              ]
            }
          }
        },
        {
          "id": "GO:0102378",
          "name": "steviolmonoside glucosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13512",
                "RHEA:61736"
              ],
              "previous": [
                "MetaCyc:RXN-13512"
              ]
            }
          }
        },
        {
          "id": "GO:0102379",
          "name": "steviolbioside glucosyltransferase activity (stevioside forming)",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13514",
                "RHEA:61744"
              ],
              "previous": [
                "MetaCyc:RXN-13514"
              ]
            }
          }
        },
        {
          "id": "GO:0102380",
          "name": "steviolbioside glucosyltransferase activity (rebaudioside B forming)",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13516",
                "RHEA:61752"
              ],
              "previous": [
                "MetaCyc:RXN-13516"
              ]
            }
          }
        },
        {
          "id": "GO:0102381",
          "name": "stevioside glucosyltransferase activity (rebaudioside A forming)",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13517",
                "RHEA:61756"
              ],
              "previous": [
                "MetaCyc:RXN-13517"
              ]
            }
          }
        },
        {
          "id": "GO:0102382",
          "name": "rebaudioside B glucosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13518",
                "RHEA:61760"
              ],
              "previous": [
                "MetaCyc:RXN-13518"
              ]
            }
          }
        },
        {
          "id": "GO:0102432",
          "name": "quercetin 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13906",
                "RHEA:73115"
              ],
              "previous": [
                "MetaCyc:RXN-13906"
              ]
            }
          }
        },
        {
          "id": "GO:0102435",
          "name": "myricetin 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13910",
                "RHEA:74719"
              ],
              "previous": [
                "MetaCyc:RXN-13910"
              ]
            }
          }
        },
        {
          "id": "GO:0102439",
          "name": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13916",
                "RHEA:74739"
              ],
              "previous": [
                "MetaCyc:RXN-13916"
              ]
            }
          }
        },
        {
          "id": "GO:0102440",
          "name": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13918",
                "RHEA:74771"
              ],
              "previous": [
                "MetaCyc:RXN-13918"
              ]
            }
          }
        },
        {
          "id": "GO:0102441",
          "name": "syringetin 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13919",
                "RHEA:74735"
              ],
              "previous": [
                "MetaCyc:RXN-13919"
              ]
            }
          }
        },
        {
          "id": "GO:0102442",
          "name": "syringetin 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13920",
                "RHEA:74767"
              ],
              "previous": [
                "MetaCyc:RXN-13920"
              ]
            }
          }
        },
        {
          "id": "GO:0102444",
          "name": "isorhamnetin 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13929",
                "RHEA:74759"
              ],
              "previous": [
                "MetaCyc:RXN-13929"
              ]
            }
          }
        },
        {
          "id": "GO:0102445",
          "name": "3-methylquercetin 3'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13930",
                "RHEA:74715"
              ],
              "previous": [
                "MetaCyc:RXN-13930"
              ]
            }
          }
        },
        {
          "id": "GO:0102446",
          "name": "rhamnetin 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13932",
                "RHEA:74763"
              ],
              "previous": [
                "MetaCyc:RXN-13932"
              ]
            }
          }
        },
        {
          "id": "GO:0102447",
          "name": "rhamnetin 3'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13933",
                "RHEA:73271"
              ],
              "previous": [
                "MetaCyc:RXN-13933"
              ]
            }
          }
        },
        {
          "id": "GO:0102448",
          "name": "rhamnetin 4'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13934",
                "RHEA:74731"
              ],
              "previous": [
                "MetaCyc:RXN-13934"
              ]
            }
          }
        },
        {
          "id": "GO:0102449",
          "name": "kaempferol 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13935",
                "RHEA:74743"
              ],
              "previous": [
                "MetaCyc:RXN-13935"
              ]
            }
          }
        },
        {
          "id": "GO:0102450",
          "name": "kaempferide 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13936",
                "RHEA:74775"
              ],
              "previous": [
                "MetaCyc:RXN-13936"
              ]
            }
          }
        },
        {
          "id": "GO:0102451",
          "name": "kaempferide 3-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-13937",
                "RHEA:74755"
              ],
              "previous": [
                "MetaCyc:RXN-13937"
              ]
            }
          }
        },
        {
          "id": "GO:0102506",
          "name": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.299",
                "KEGG_REACTION:R10261",
                "MetaCyc:RXN-13967",
                "RHEA:35427"
              ],
              "previous": [
                "EC:2.4.1.299",
                "MetaCyc:RXN-14432"
              ]
            }
          }
        },
        {
          "id": "GO:0102529",
          "name": "apigenin 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14661",
                "RHEA:73071"
              ],
              "previous": [
                "MetaCyc:RXN-14661"
              ]
            }
          }
        },
        {
          "id": "GO:0102532",
          "name": "genkwanin 6-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14748",
                "RHEA:73427"
              ],
              "previous": [
                "MetaCyc:RXN-14748"
              ]
            }
          }
        },
        {
          "id": "GO:0102533",
          "name": "genkwanin 4'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14750",
                "RHEA:73263"
              ],
              "previous": [
                "MetaCyc:RXN-14750"
              ]
            }
          }
        },
        {
          "id": "GO:0102534",
          "name": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14751",
                "RHEA:73435"
              ],
              "previous": [
                "MetaCyc:RXN-14751"
              ]
            }
          }
        },
        {
          "id": "GO:0102535",
          "name": "ladanein 6-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14752",
                "RHEA:73247"
              ],
              "previous": [
                "MetaCyc:RXN-14752"
              ]
            }
          }
        },
        {
          "id": "GO:0102536",
          "name": "sakuranetin 6-hydroxylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-14754",
                "RHEA:73431"
              ],
              "previous": [
                "MetaCyc:RXN-14754"
              ]
            }
          }
        },
        {
          "id": "GO:0102561",
          "name": "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.4.57",
                "MetaCyc:RXN-14996"
              ],
              "previous": [
                "EC:3.1.4.57",
                "MetaCyc:RXN-14996",
                "RHEA:41616"
              ]
            }
          }
        },
        {
          "id": "GO:0102571",
          "name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.1.169",
                "MetaCyc:RXN-15215"
              ],
              "previous": [
                "EC:3.2.1.169",
                "MetaCyc:RXN-11891",
                "MetaCyc:RXN-15215"
              ]
            }
          }
        },
        {
          "id": "GO:0102585",
          "name": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-15331",
                "RHEA:72871"
              ],
              "previous": [
                "MetaCyc:RXN-15331"
              ]
            }
          }
        },
        {
          "id": "GO:0102623",
          "name": "scutellarein 7-methyl ether 6-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-15528",
                "RHEA:73243"
              ],
              "previous": [
                "MetaCyc:RXN-15528"
              ]
            }
          }
        },
        {
          "id": "GO:0102624",
          "name": "scutellarein 7-methyl ether 4'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-15529",
                "RHEA:73239"
              ],
              "previous": [
                "MetaCyc:RXN-15529"
              ]
            }
          }
        },
        {
          "id": "GO:0102625",
          "name": "cirsimaritin 4'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-15530",
                "RHEA:73251"
              ],
              "previous": [
                "MetaCyc:RXN-15530"
              ]
            }
          }
        },
        {
          "id": "GO:0102672",
          "name": "fatty acid alpha-dioxygenase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.13.11.92",
                "MetaCyc:RXN-4121",
                "RHEA:63508"
              ],
              "previous": [
                "MetaCyc:RXN-4121"
              ]
            }
          }
        },
        {
          "id": "GO:0102720",
          "name": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.3.1.224"
              ],
              "previous": [
                "EC:2.3.1.224",
                "MetaCyc:RXN-6762",
                "RHEA:36147"
              ]
            }
          }
        },
        {
          "id": "GO:0102734",
          "name": "brassinolide synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.14.180",
                "MetaCyc:RXN-720"
              ],
              "previous": [
                "MetaCyc:RXN-720"
              ]
            }
          }
        },
        {
          "id": "GO:0102741",
          "name": "caffeine synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.160"
              ],
              "previous": [
                "EC:2.1.1.160",
                "MetaCyc:RXN-7601",
                "RHEA:10280"
              ]
            }
          }
        },
        {
          "id": "GO:0102767",
          "name": "flavanone 4'-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.231",
                "MetaCyc:RXN-12719",
                "RHEA:31743"
              ],
              "previous": [
                "EC:2.1.1.231",
                "MetaCyc:RXN-7777",
                "RHEA:31743"
              ]
            }
          }
        },
        {
          "id": "GO:0102882",
          "name": "beta-acoradiene synthase activity",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:RXN-8423",
                "RHEA:68520"
              ],
              "previous": [
                "MetaCyc:RXN-8423"
              ]
            }
          }
        },
        {
          "id": "GO:0102890",
          "name": "chalcone 4'-O-glucosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.1.286"
              ],
              "previous": [
                "EC:2.4.1.286",
                "MetaCyc:RXN-8453",
                "RHEA:34291"
              ]
            }
          }
        },
        {
          "id": "GO:0102917",
          "name": "(R,S)-reticuline 7-O-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.291",
                "MetaCyc:RXN-8700",
                "MetaCyc:RXN-8701",
                "RHEA:38907"
              ],
              "previous": [
                "EC:2.1.1.291",
                "MetaCyc:RXN-8700",
                "RHEA:10444"
              ]
            }
          }
        },
        {
          "id": "GO:0102998",
          "name": "4-sulfomuconolactone hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.1.1.92",
                "MetaCyc:RXN-9733",
                "RHEA:33711",
                "UM-BBD_reactionID:r0583"
              ],
              "previous": [
                "EC:3.1.1.92",
                "MetaCyc:RXN-9733",
                "RHEA:33711"
              ]
            }
          }
        },
        {
          "id": "GO:0106339",
          "name": "tRNA (cytidine(32)-2'-O)-methyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.1.1.200",
                "EC:2.1.1.205",
                "MetaCyc:RXN-11866",
                "RHEA:42396",
                "RHEA:42932"
              ],
              "previous": [
                "EC:2.1.1.205",
                "MetaCyc:RXN-11866",
                "RHEA:42396"
              ]
            }
          }
        },
        {
          "id": "GO:0106407",
          "name": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:3.2.1.207"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0106437",
          "name": "protein-glutamic acid ligase activity, initiating",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:60144"
              ],
              "previous": [
                "Rhea:60144"
              ]
            }
          }
        },
        {
          "id": "GO:0106438",
          "name": "protein-glutamic acid ligase activity, elongating",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:60148"
              ],
              "previous": [
                "Rhea:60148"
              ]
            }
          }
        },
        {
          "id": "GO:0140292",
          "name": "ADP-ribosylserine hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:58256"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0140680",
          "name": "histone H3K36me/H3K36me2 demethylase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.14.11.27",
                "MetaCyc:RXN-13186",
                "RHEA:42032"
              ],
              "previous": [
                "EC:1.14.11.27",
                "MetaCyc:RXN-8661",
                "RHEA:42032"
              ]
            }
          }
        },
        {
          "id": "GO:0140741",
          "name": "tRNA-uracil-4 sulfurtransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.8.1.4",
                "MetaCyc:RXN-18388",
                "RHEA:24176"
              ],
              "previous": [
                "EC:2.8.1.4",
                "MetaCyc:TRNA-S-TRANSFERASE-RXN",
                "RHEA:24176"
              ]
            }
          }
        },
        {
          "id": "GO:0140749",
          "name": "phlorizin hydrolase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:69639"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0140806",
          "name": "NAD+-protein-aspartate ADP-ribosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:54424"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0140807",
          "name": "NAD+-protein-glutamate ADP-ribosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:58224"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0140860",
          "name": "(3R)-2'-hydroxyisoflavanone reductase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:56284"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0140951",
          "name": "histone H3K27 trimethyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:60292"
              ],
              "previous": [
                "EC:2.1.1.356",
                "RHEA:60292"
              ]
            }
          }
        },
        {
          "id": "GO:1990189",
          "name": "peptide-serine-alpha-N-acetyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:50504"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1990464",
          "name": "D-2-hydroxyacid dehydrogenase (quinone) activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:1.1.5.10",
                "MetaCyc:RXN-14931",
                "RHEA:11272"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1990534",
          "name": "thermospermine oxidase activity",
          "changes": {
            "xrefs": {
              "current": [
                "RHEA:57836"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:1990585",
          "name": "hydroxyproline O-arabinosyltransferase activity",
          "changes": {
            "xrefs": {
              "current": [
                "EC:2.4.2.58",
                "MetaCyc:RXN-15011",
                "RHEA:49472"
              ],
              "previous": "N/A"
            }
          }
        }
      ],
      "biological_process": [
        {
          "id": "GO:0006043",
          "name": "glucosamine catabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:GLUAMCAT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0006055",
          "name": "CMP-N-acetylneuraminate biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-6138",
                "MetaCyc:PWY-6139"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0009085",
          "name": "lysine biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:LYSINE-SYN"
              ],
              "previous": [
                "MetaCyc:PWY-5097"
              ]
            }
          }
        },
        {
          "id": "GO:0009438",
          "name": "methylglyoxal metabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:METHGLYUT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0009821",
          "name": "alkaloid biosynthetic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "UM-BBD_enzymeID:e0711"
              ]
            }
          }
        },
        {
          "id": "GO:0009849",
          "name": "tryptophan-independent indoleacetic acid biosynthetic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:PWY-581"
              ]
            }
          }
        },
        {
          "id": "GO:0010130",
          "name": "anaerobic ethylbenzene catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-481",
                "UM-BBD_pathwayID:ethb"
              ],
              "previous": [
                "MetaCyc:PWY-481"
              ]
            }
          }
        },
        {
          "id": "GO:0010137",
          "name": "ureide biosynthetic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:URSIN-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0015940",
          "name": "pantothenate biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PANTO-PWY",
                "MetaCyc:PWY-3961"
              ],
              "previous": [
                "MetaCyc:PANTO-PWY",
                "MetaCyc:PANTOSYN-PWY",
                "MetaCyc:PWY-3961",
                "MetaCyc:PWY-4221"
              ]
            }
          }
        },
        {
          "id": "GO:0018925",
          "name": "m-cresol metabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "UM-BBD_pathwayID:mcr"
              ],
              "previous": [
                "MetaCyc:M-CRESOL-DEGRADATION-PWY",
                "UM-BBD_pathwayID:mcr"
              ]
            }
          }
        },
        {
          "id": "GO:0019256",
          "name": "acrylonitrile catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:P344-PWY",
                "UM-BBD_pathwayID:acr"
              ],
              "previous": [
                "MetaCyc:P344-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019261",
          "name": "1,4-dichlorobenzene catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:14DICHLORBENZDEG-PWY",
                "UM-BBD_pathwayID:dcz"
              ],
              "previous": [
                "MetaCyc:14DICHLORBENZDEG-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019325",
          "name": "anaerobic fructose catabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:ANAEROFRUCAT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019337",
          "name": "tetrachloroethylene catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PCEDEG-PWY",
                "UM-BBD_pathwayID:tce2"
              ],
              "previous": [
                "MetaCyc:PCEDEG-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019381",
          "name": "atrazine catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-5724"
              ],
              "previous": [
                "MetaCyc:P141-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019395",
          "name": "fatty acid oxidation",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:FAO-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019418",
          "name": "sulfide oxidation",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:Sulfide-Oxidation"
              ],
              "previous": [
                "MetaCyc:P222-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019563",
          "name": "glycerol catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:GLYCEROL-DEG"
              ],
              "previous": [
                "MetaCyc:PWY-4261",
                "MetaCyc:PWY0-381"
              ]
            }
          }
        },
        {
          "id": "GO:0019584",
          "name": "galactonate catabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:GALACTCAT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019590",
          "name": "L-arabitol catabolic process to xylulose 5-phosphate",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:LARABITOLUTIL-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019595",
          "name": "non-phosphorylated glucose catabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:NPGLUCAT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0019624",
          "name": "atrazine catabolic process to isopropylamine",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:P141-PWY"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0019650",
          "name": "glycolytic fermentation to butanediol",
          "changes": {
            "xrefs": {
              "current": [
                "Wikipedia:Butanediol_fermentation"
              ],
              "previous": [
                "MetaCyc:P125-PWY",
                "Wikipedia:Butanediol_fermentation"
              ]
            }
          }
        },
        {
          "id": "GO:0033310",
          "name": "chlorophyll a catabolic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-5098"
              ],
              "previous": [
                "MetaCyc:PWY-5086",
                "MetaCyc:PWY-5098"
              ]
            }
          }
        },
        {
          "id": "GO:0033323",
          "name": "choline biosynthetic process via CDP-choline",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-3561"
              ],
              "previous": [
                "MetaCyc:PWY-3561",
                "MetaCyc:PWY-4762"
              ]
            }
          }
        },
        {
          "id": "GO:0033324",
          "name": "choline biosynthetic process via N-monomethylethanolamine",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-3542"
              ],
              "previous": [
                "MetaCyc:PWY-3542",
                "MetaCyc:PWY-4762"
              ]
            }
          }
        },
        {
          "id": "GO:0033325",
          "name": "choline biosynthetic process via phosphoryl-ethanolamine",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-3385"
              ],
              "previous": [
                "MetaCyc:PWY-3385",
                "MetaCyc:PWY-4762"
              ]
            }
          }
        },
        {
          "id": "GO:0033332",
          "name": "ent-kaurene biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-5032"
              ],
              "previous": [
                "MetaCyc:PWY-5032",
                "MetaCyc:PWY-5035"
              ]
            }
          }
        },
        {
          "id": "GO:0033352",
          "name": "UDP-D-apiose biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-5113"
              ],
              "previous": [
                "MetaCyc:PWY-4821",
                "MetaCyc:PWY-5113"
              ]
            }
          }
        },
        {
          "id": "GO:0033468",
          "name": "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-1269"
              ],
              "previous": [
                "MetaCyc:KDOSYN-PWY",
                "MetaCyc:PWY-1269"
              ]
            }
          }
        },
        {
          "id": "GO:0033478",
          "name": "UDP-rhamnose metabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:PWY-3261"
              ]
            }
          }
        },
        {
          "id": "GO:0033559",
          "name": "unsaturated fatty acid metabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:PWY-762",
                "MetaCyc:PWY-782"
              ]
            }
          }
        },
        {
          "id": "GO:0034195",
          "name": "L-galactonate catabolic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:GALACTCAT-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0046656",
          "name": "folic acid biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "Wikipedia:Folic_acid"
              ],
              "previous": [
                "MetaCyc:FOLSYN-PWY",
                "Wikipedia:Folic_acid"
              ]
            }
          }
        },
        {
          "id": "GO:0051484",
          "name": "isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:NONMEVIPP-PWY"
              ]
            }
          }
        },
        {
          "id": "GO:0052889",
          "name": "9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-6475"
              ],
              "previous": [
                "KEGG_REACTION:R07511",
                "MetaCyc:RXN-12242"
              ]
            }
          }
        },
        {
          "id": "GO:0061616",
          "name": "glycolytic process from fructose through fructose-6-phosphate",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:PWY-5484"
              ]
            }
          }
        },
        {
          "id": "GO:0141199",
          "name": "GDP-mannose biosynthetic process from glucose",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:PWY-5659"
              ]
            }
          }
        },
        {
          "id": "GO:1902756",
          "name": "sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process",
          "changes": {
            "xrefs": {
              "current": [
                "MetaCyc:PWY-5963"
              ],
              "previous": [
                "MetaCyc:PWY-6476"
              ]
            }
          }
        }
      ],
      "cellular_component": [
        {
          "id": "GO:0072669",
          "name": "tRNA-splicing ligase complex",
          "changes": {
            "xrefs": {
              "current": "N/A",
              "previous": [
                "MetaCyc:ENTMULTI-CPLX"
              ]
            }
          }
        }
      ]
    },
    "relations": {
      "biological_process": [
        {
          "id": "GO:0000050",
          "name": "urea cycle",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019627",
                "GO:0043604"
              ],
              "previous": [
                "GO:0019627",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0000096",
          "name": "sulfur amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006790",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0000097",
          "name": "sulfur amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000096",
                "GO:0044272",
                "GO:0046394"
              ],
              "previous": [
                "GO:0000096",
                "GO:0044272",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0000098",
          "name": "sulfur amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000096",
                "GO:0044273",
                "GO:0046395"
              ],
              "previous": [
                "GO:0000096",
                "GO:0044273",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0000162",
          "name": "tryptophan biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009073",
                "GO:0046219",
                "GO:1901607"
              ],
              "previous": [
                "GO:0006568",
                "GO:0009073",
                "GO:0046219",
                "GO:1901607"
              ]
            }
          }
        },
        {
          "id": "GO:0000196",
          "name": "cell integrity MAPK cascade",
          "changes": {
            "relationship": {
              "current": "N/A",
              "previous": [
                "part_of GO:0071554"
              ]
            },
            "intersection_of": {
              "current": "N/A",
              "previous": [
                "is_a GO:0051403",
                "part_of GO:0071554"
              ]
            }
          }
        },
        {
          "id": "GO:0000255",
          "name": "allantoin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0000256",
          "name": "allantoin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000255",
                "GO:0043605"
              ],
              "previous": [
                "GO:0000255",
                "GO:0043605",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0002047",
          "name": "phenazine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017000"
              ],
              "previous": [
                "GO:0017000",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0002049",
          "name": "pyoverdine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019290",
                "GO:0043604"
              ],
              "previous": [
                "GO:0019290",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0002050",
          "name": "pyoverdine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:0046215"
              ],
              "previous": [
                "GO:0043603",
                "GO:0046215",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0002936",
          "name": "bradykinin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043043",
                "GO:0043604"
              ],
              "previous": [
                "GO:0043043",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0006022",
          "name": "aminoglycan metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043170",
                "GO:1901135"
              ],
              "previous": [
                "GO:0043170",
                "GO:1901135",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0006023",
          "name": "aminoglycan biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006022",
                "GO:0009059",
                "GO:1901137"
              ],
              "previous": [
                "GO:0006022",
                "GO:0009059",
                "GO:1901137",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0006026",
          "name": "aminoglycan catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006022",
                "GO:0009057",
                "GO:1901136"
              ],
              "previous": [
                "GO:0006022",
                "GO:0009057",
                "GO:1901136",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0006054",
          "name": "N-acetylneuraminate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006040",
                "GO:0019752",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006040",
                "GO:0019752",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0006412",
          "name": "translation",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0019538"
              ],
              "previous": [
                "GO:0009059",
                "GO:0019538",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0006488",
          "name": "dolichol-linked oligosaccharide biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006490"
              ],
              "previous": [
                "GO:0006490",
                "GO:0019348"
              ]
            },
            "relationship": {
              "current": [
                "part_of GO:0018279"
              ],
              "previous": [
                "part_of GO:0006487"
              ]
            }
          }
        },
        {
          "id": "GO:0006490",
          "name": "oligosaccharide-lipid intermediate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901137"
              ],
              "previous": [
                "GO:0044255",
                "GO:1901137"
              ]
            }
          }
        },
        {
          "id": "GO:0006568",
          "name": "tryptophan metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006586",
                "GO:0009072",
                "GO:1902221"
              ],
              "previous": [
                "GO:0006586",
                "GO:0009072",
                "GO:1901605"
              ]
            }
          }
        },
        {
          "id": "GO:0006569",
          "name": "tryptophan catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006586",
                "GO:0009074",
                "GO:0042436",
                "GO:1901606"
              ],
              "previous": [
                "GO:0006568",
                "GO:0009074",
                "GO:0042436",
                "GO:1901606"
              ]
            }
          }
        },
        {
          "id": "GO:0006575",
          "name": "cellular modified amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044237"
              ],
              "previous": [
                "GO:0044237",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0006587",
          "name": "serotonin biosynthetic process from tryptophan",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006586",
                "GO:0009072",
                "GO:0042427",
                "GO:1901605"
              ],
              "previous": [
                "GO:0006568",
                "GO:0042427"
              ]
            }
          }
        },
        {
          "id": "GO:0006656",
          "name": "phosphatidylcholine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046470",
                "GO:0046474"
              ],
              "previous": [
                "GO:0046470",
                "GO:0046474",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0006663",
          "name": "platelet activating factor biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008611",
                "GO:0046469",
                "GO:0046474"
              ],
              "previous": [
                "GO:0008611",
                "GO:0046469",
                "GO:0046474",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0006665",
          "name": "sphingolipid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006643"
              ],
              "previous": [
                "GO:0006643",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0006748",
          "name": "lipoamide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006790",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0006768",
          "name": "biotin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006767",
                "GO:0006790",
                "GO:0032787",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006767",
                "GO:0006790",
                "GO:0032787",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009050",
          "name": "glycopeptide catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:1901136"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901136",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009072",
          "name": "aromatic amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009073",
          "name": "aromatic amino acid family biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009072",
                "GO:0046394"
              ],
              "previous": [
                "GO:0009072",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009074",
          "name": "aromatic amino acid family catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009072",
                "GO:0046395"
              ],
              "previous": [
                "GO:0009072",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009081",
          "name": "branched-chain amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009082",
          "name": "branched-chain amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009081",
                "GO:0046394"
              ],
              "previous": [
                "GO:0009081",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009083",
          "name": "branched-chain amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009063",
                "GO:0009081",
                "GO:0046395"
              ],
              "previous": [
                "GO:0009063",
                "GO:0009081",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009101",
          "name": "glycoprotein biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0009100",
                "GO:1901137"
              ],
              "previous": [
                "GO:0009059",
                "GO:0009100",
                "GO:1901137",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009102",
          "name": "biotin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006768",
                "GO:0042364",
                "GO:0043604",
                "GO:0044272",
                "GO:0072330"
              ],
              "previous": [
                "GO:0006768",
                "GO:0042364",
                "GO:0043604",
                "GO:0044272",
                "GO:0072330",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009112",
          "name": "nucleobase metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0055086"
              ],
              "previous": [
                "GO:0055086",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009116",
          "name": "nucleoside metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0055086",
                "GO:1901657"
              ],
              "previous": [
                "GO:0055086",
                "GO:1901564",
                "GO:1901657"
              ]
            }
          }
        },
        {
          "id": "GO:0009163",
          "name": "nucleoside biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009116",
                "GO:0034404",
                "GO:1901659"
              ],
              "previous": [
                "GO:0009116",
                "GO:0034404",
                "GO:1901566",
                "GO:1901659"
              ]
            }
          }
        },
        {
          "id": "GO:0009164",
          "name": "nucleoside catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009116",
                "GO:0034656",
                "GO:1901658"
              ],
              "previous": [
                "GO:0009116",
                "GO:0034656",
                "GO:1901565",
                "GO:1901658"
              ]
            }
          }
        },
        {
          "id": "GO:0009308",
          "name": "amine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009309",
          "name": "amine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0009308"
              ],
              "previous": [
                "GO:0009308",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009310",
          "name": "amine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0009308"
              ],
              "previous": [
                "GO:0009308",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009439",
          "name": "cyanate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006082"
              ],
              "previous": [
                "GO:0006082",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009440",
          "name": "cyanate catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0009439"
              ],
              "previous": [
                "GO:0009439",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009820",
          "name": "alkaloid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0009821",
          "name": "alkaloid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009820",
                "GO:0044550"
              ],
              "previous": [
                "GO:0009820",
                "GO:0044550",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0009822",
          "name": "alkaloid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0009820"
              ],
              "previous": [
                "GO:0009820",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0009961",
          "name": "response to 1-aminocyclopropane-1-carboxylic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0010130",
          "name": "anaerobic ethylbenzene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0018915"
              ],
              "previous": [
                "GO:0018913"
              ]
            }
          }
        },
        {
          "id": "GO:0010200",
          "name": "response to chitin",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0010238",
          "name": "response to proline",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0010266",
          "name": "response to vitamin B1",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:0097305",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:0097305"
              ]
            }
          }
        },
        {
          "id": "GO:0010814",
          "name": "substance P catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010813",
                "GO:0043603"
              ],
              "previous": [
                "GO:0010813",
                "GO:0043603",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0010815",
          "name": "bradykinin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0010816",
          "name": "calcitonin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042447",
                "GO:0043603"
              ],
              "previous": [
                "GO:0042447",
                "GO:0043603",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0014074",
          "name": "response to purine-containing compound",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0014075",
          "name": "response to amine",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0016063",
          "name": "rhodopsin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006726",
                "GO:0009059",
                "GO:0046154"
              ],
              "previous": [
                "GO:0006726",
                "GO:0009059",
                "GO:0046154",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0018161",
          "name": "dipyrrin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0046453"
              ],
              "previous": [
                "GO:0046453",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0018189",
          "name": "pyrroloquinoline quinone biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042181",
                "GO:0072351"
              ],
              "previous": [
                "GO:0042181",
                "GO:0072351",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0018884",
          "name": "carbazole metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0018889",
          "name": "2-chloro-N-isopropylacetanilide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042537",
                "GO:0043603"
              ],
              "previous": [
                "GO:0042537",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0018911",
          "name": "1,2,4-trichlorobenzene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042537"
              ],
              "previous": [
                "GO:0042537"
              ]
            }
          }
        },
        {
          "id": "GO:0018914",
          "name": "chlorobenzene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042537"
              ],
              "previous": [
                "GO:0042537"
              ]
            }
          }
        },
        {
          "id": "GO:0018915",
          "name": "ethylbenzene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042537",
                "GO:0120253"
              ],
              "previous": [
                "GO:0042537",
                "GO:0120252"
              ]
            }
          }
        },
        {
          "id": "GO:0018930",
          "name": "3-methylquinoline metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0018934",
          "name": "nitrilotriacetate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006805",
                "GO:0072350"
              ],
              "previous": [
                "GO:0006805",
                "GO:0072350",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0018965",
          "name": "s-triazine compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006805"
              ],
              "previous": [
                "GO:0006805",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019256",
          "name": "acrylonitrile catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042178",
                "GO:0050899"
              ],
              "previous": [
                "GO:0018865",
                "GO:0042178",
                "GO:0050899"
              ]
            }
          }
        },
        {
          "id": "GO:0019261",
          "name": "1,4-dichlorobenzene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042537"
              ],
              "previous": [
                "GO:0009056",
                "GO:0018912"
              ]
            }
          }
        },
        {
          "id": "GO:0019262",
          "name": "N-acetylneuraminate catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006054",
                "GO:0046348",
                "GO:0046395"
              ],
              "previous": [
                "GO:0006054",
                "GO:0046348",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0019289",
          "name": "rhizobactin 1021 biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0046394",
                "GO:0046494",
                "GO:1902645"
              ],
              "previous": [
                "GO:0043604",
                "GO:0046394",
                "GO:0046494",
                "GO:1901566",
                "GO:1902645"
              ]
            }
          }
        },
        {
          "id": "GO:0019335",
          "name": "3-methylquinoline catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0018930",
                "GO:0042178"
              ],
              "previous": [
                "GO:0018930",
                "GO:0042178",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0019337",
          "name": "tetrachloroethylene catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042205"
              ],
              "previous": [
                "GO:0018967",
                "GO:0042205"
              ]
            }
          }
        },
        {
          "id": "GO:0019351",
          "name": "dethiobiotin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0046450",
                "GO:0072330"
              ],
              "previous": [
                "GO:0043604",
                "GO:0046450",
                "GO:0072330",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0019356",
          "name": "nicotinate nucleotide biosynthetic process from tryptophan",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006586",
                "GO:0009072",
                "GO:0019357",
                "GO:1901605"
              ],
              "previous": [
                "GO:0006568",
                "GO:0019357"
              ]
            }
          }
        },
        {
          "id": "GO:0019428",
          "name": "allantoin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000255",
                "GO:0043604"
              ],
              "previous": [
                "GO:0000255",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0019491",
          "name": "ectoine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042399",
                "GO:0072330"
              ],
              "previous": [
                "GO:0042399",
                "GO:0072330",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0019529",
          "name": "taurine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019530",
                "GO:0046306"
              ],
              "previous": [
                "GO:0019530",
                "GO:0046306",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0019530",
          "name": "taurine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019694"
              ],
              "previous": [
                "GO:0019694",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019536",
          "name": "vibriobactin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009237",
                "GO:0043603"
              ],
              "previous": [
                "GO:0009237",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019537",
          "name": "vibriobactin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019536",
                "GO:0043604"
              ],
              "previous": [
                "GO:0019536",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0019538",
          "name": "protein metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043170",
                "GO:0044238"
              ],
              "previous": [
                "GO:0043170",
                "GO:0044238",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019627",
          "name": "urea metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:0044281",
                "GO:0071941"
              ],
              "previous": [
                "GO:0043603",
                "GO:0044281",
                "GO:0071941",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019640",
          "name": "D-glucuronate catabolic process to D-xylulose 5-phosphate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042840",
                "GO:1901159"
              ],
              "previous": [
                "GO:0006064",
                "GO:1901159"
              ]
            }
          }
        },
        {
          "id": "GO:0019760",
          "name": "glucosinolate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016143",
                "GO:0043436"
              ],
              "previous": [
                "GO:0016143",
                "GO:0043436",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0019761",
          "name": "glucosinolate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016144",
                "GO:0019760"
              ],
              "previous": [
                "GO:0016144",
                "GO:0019760",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0019762",
          "name": "glucosinolate catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016145",
                "GO:0019760"
              ],
              "previous": [
                "GO:0016145",
                "GO:0019760",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0019877",
          "name": "diaminopimelate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008652",
                "GO:0043650",
                "GO:0046451",
                "GO:1901570"
              ],
              "previous": [
                "GO:0008652",
                "GO:0043650",
                "GO:0046451",
                "GO:1901566",
                "GO:1901570"
              ]
            }
          }
        },
        {
          "id": "GO:0030148",
          "name": "sphingolipid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006665",
                "GO:0046467"
              ],
              "previous": [
                "GO:0006665",
                "GO:0046467",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0030149",
          "name": "sphingolipid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006665",
                "GO:0046466"
              ],
              "previous": [
                "GO:0006665",
                "GO:0046466",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0030163",
          "name": "protein catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009057",
                "GO:0019538"
              ],
              "previous": [
                "GO:0009057",
                "GO:0019538",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0030259",
          "name": "lipid glycosylation",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008610",
                "GO:0030258",
                "GO:0070085"
              ],
              "previous": [
                "GO:0030258",
                "GO:0070085"
              ]
            }
          }
        },
        {
          "id": "GO:0030393",
          "name": "fructoselysine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019752",
                "GO:0030389"
              ],
              "previous": [
                "GO:0019752",
                "GO:0030389",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0030650",
          "name": "peptide antibiotic metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006518",
                "GO:0016999",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006518",
                "GO:0016999",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0030651",
          "name": "peptide antibiotic biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017000",
                "GO:0030650",
                "GO:0043043",
                "GO:0043604"
              ],
              "previous": [
                "GO:0017000",
                "GO:0030650",
                "GO:0043043",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0030652",
          "name": "peptide antibiotic catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017001",
                "GO:0030650",
                "GO:0043171"
              ],
              "previous": [
                "GO:0017001",
                "GO:0030650",
                "GO:0043171",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0031108",
          "name": "holo-[acyl-carrier-protein] biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0019538"
              ],
              "previous": [
                "GO:0009059",
                "GO:0019538",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0031168",
          "name": "ferrichrome metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009237",
                "GO:0043603"
              ],
              "previous": [
                "GO:0009237",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0031169",
          "name": "ferrichrome biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019539",
                "GO:0031168",
                "GO:0043604"
              ],
              "previous": [
                "GO:0019539",
                "GO:0031168",
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0031427",
          "name": "response to methotrexate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0031590",
          "name": "wybutosine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901657"
              ],
              "previous": [
                "GO:1901564",
                "GO:1901657"
              ]
            }
          }
        },
        {
          "id": "GO:0031591",
          "name": "wybutosine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006400",
                "GO:0031590",
                "GO:1901659"
              ],
              "previous": [
                "GO:0006400",
                "GO:0031590",
                "GO:1901566",
                "GO:1901659"
              ]
            }
          }
        },
        {
          "id": "GO:0032324",
          "name": "molybdopterin cofactor biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043545",
                "GO:0090407"
              ],
              "previous": [
                "GO:0043545",
                "GO:0090407",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0032325",
          "name": "molybdopterin cofactor catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043545",
                "GO:0046434"
              ],
              "previous": [
                "GO:0043545",
                "GO:0046434",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0032494",
          "name": "response to peptidoglycan",
          "changes": {
            "is_a": {
              "current": [
                "GO:0002237",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0002237",
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0032495",
          "name": "response to muramyl dipeptide",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0032604",
          "name": "granulocyte macrophage colony-stimulating factor production",
          "changes": {
            "is_a": {
              "current": [
                "GO:0001816",
                "GO:0019538"
              ],
              "previous": [
                "GO:0001816",
                "GO:0019538",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0032605",
          "name": "hepatocyte growth factor production",
          "changes": {
            "is_a": {
              "current": [
                "GO:0001816",
                "GO:0019538"
              ],
              "previous": [
                "GO:0001816",
                "GO:0019538",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0032641",
          "name": "lymphotoxin A production",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019538",
                "GO:0071706"
              ],
              "previous": [
                "GO:0019538",
                "GO:0071706",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0032981",
          "name": "mitochondrial respiratory chain complex I assembly",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010257",
                "GO:0033108",
                "GO:0097250"
              ],
              "previous": [
                "GO:0010257",
                "GO:0033108"
              ]
            }
          }
        },
        {
          "id": "GO:0033013",
          "name": "tetrapyrrole metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0033014",
          "name": "tetrapyrrole biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0033013"
              ],
              "previous": [
                "GO:0033013",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0033015",
          "name": "tetrapyrrole catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0033013"
              ],
              "previous": [
                "GO:0033013",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0033051",
          "name": "aminophosphonate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019637"
              ],
              "previous": [
                "GO:0019637",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0033274",
          "name": "response to vitamin B2",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0033321",
          "name": "homomethionine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019752"
              ],
              "previous": [
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0033322",
          "name": "homomethionine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033321",
                "GO:0046394"
              ],
              "previous": [
                "GO:0033321",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0033590",
          "name": "response to cobalamin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0033614",
          "name": "chloroplast proton-transporting ATP synthase complex assembly",
          "changes": {
            "relationship": {
              "current": [
                "occurs_in GO:0009507",
                "part_of GO:0009658"
              ],
              "previous": [
                "part_of GO:0009658"
              ]
            },
            "intersection_of": {
              "current": [
                "is_a GO:0043461",
                "occurs_in GO:0009507"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033615",
          "name": "mitochondrial proton-transporting ATP synthase complex assembly",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043461",
                "GO:0097250"
              ],
              "previous": [
                "GO:0043461"
              ]
            },
            "relationship": {
              "current": [
                "part_of GO:0007005"
              ],
              "previous": [
                "occurs_in GO:0005739",
                "part_of GO:0007005"
              ]
            }
          }
        },
        {
          "id": "GO:0033616",
          "name": "plasma membrane proton-transporting ATP synthase complex assembly",
          "changes": {
            "relationship": {
              "current": [
                "occurs_in GO:0005886",
                "part_of GO:0007009"
              ],
              "previous": [
                "part_of GO:0007009"
              ]
            },
            "intersection_of": {
              "current": [
                "is_a GO:0043461",
                "occurs_in GO:0005886"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0033617",
          "name": "mitochondrial cytochrome c oxidase assembly",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008535",
                "GO:0033108",
                "GO:0097250"
              ],
              "previous": [
                "GO:0008535",
                "GO:0033108"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "occurs_in GO:0005739"
              ]
            }
          }
        },
        {
          "id": "GO:0034275",
          "name": "kynurenic acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032787"
              ],
              "previous": [
                "GO:0032787",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0034276",
          "name": "kynurenic acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0034275",
                "GO:0072330"
              ],
              "previous": [
                "GO:0034275",
                "GO:0072330",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0034516",
          "name": "response to vitamin B6",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0034551",
          "name": "mitochondrial respiratory chain complex III assembly",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017062",
                "GO:0033108",
                "GO:0097250"
              ],
              "previous": [
                "GO:0017062",
                "GO:0033108"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "occurs_in GO:0005739"
              ]
            }
          }
        },
        {
          "id": "GO:0034553",
          "name": "mitochondrial respiratory chain complex II assembly",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033108",
                "GO:0034552",
                "GO:0097250"
              ],
              "previous": [
                "GO:0033108",
                "GO:0034552"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "occurs_in GO:0005739"
              ]
            }
          }
        },
        {
          "id": "GO:0034638",
          "name": "phosphatidylcholine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046470",
                "GO:0046475"
              ],
              "previous": [
                "GO:0046470",
                "GO:0046475",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0034776",
          "name": "response to histamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0035498",
          "name": "carnosine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0035499",
          "name": "carnosine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008652",
                "GO:0035498",
                "GO:0043604",
                "GO:0046394"
              ],
              "previous": [
                "GO:0008652",
                "GO:0035498",
                "GO:0043604",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0035983",
          "name": "response to trichostatin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0046677",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0046677",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0035984",
          "name": "cellular response to trichostatin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:0035983",
                "GO:0071236",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0035983",
                "GO:0071236",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0036272",
          "name": "response to gemcitabine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0036274",
          "name": "response to lapatinib",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0036280",
          "name": "cellular response to L-canavanine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901354",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901354",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0036288",
          "name": "response to ximelagatran",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0036346",
          "name": "cellular response to L-cysteine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901367",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901367",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0036503",
          "name": "ERAD pathway",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010498",
                "GO:0034976",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0010498",
                "GO:0034976"
              ]
            }
          }
        },
        {
          "id": "GO:0040031",
          "name": "snRNA modification",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009451",
                "GO:0016180"
              ],
              "previous": [
                "GO:0009451",
                "GO:0016073"
              ]
            }
          }
        },
        {
          "id": "GO:0042158",
          "name": "lipoprotein biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0042157"
              ],
              "previous": [
                "GO:0009059",
                "GO:0042157",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042204",
          "name": "s-triazine compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0018965",
                "GO:0042178"
              ],
              "previous": [
                "GO:0018965",
                "GO:0042178",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042219",
          "name": "cellular modified amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006575",
                "GO:0009056"
              ],
              "previous": [
                "GO:0006575",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042367",
          "name": "biotin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006768",
                "GO:0042365",
                "GO:0043605",
                "GO:0044273",
                "GO:0072329"
              ],
              "previous": [
                "GO:0006768",
                "GO:0042365",
                "GO:0043605",
                "GO:0044273",
                "GO:0072329",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042398",
          "name": "cellular modified amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006575",
                "GO:0009058"
              ],
              "previous": [
                "GO:0006575",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042399",
          "name": "ectoine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032787"
              ],
              "previous": [
                "GO:0032787",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0042400",
          "name": "ectoine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042399",
                "GO:0072329"
              ],
              "previous": [
                "GO:0042399",
                "GO:0072329",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042412",
          "name": "taurine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019530",
                "GO:0046305"
              ],
              "previous": [
                "GO:0019530",
                "GO:0046305",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042430",
          "name": "indole-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0042435",
          "name": "indole-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0042430"
              ],
              "previous": [
                "GO:0042430",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042436",
          "name": "indole-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042430"
              ],
              "previous": [
                "GO:0042430",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042541",
          "name": "hemoglobin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0020027"
              ],
              "previous": [
                "GO:0009059",
                "GO:0020027",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042558",
          "name": "pteridine-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0042559",
          "name": "pteridine-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0042558"
              ],
              "previous": [
                "GO:0042558",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042560",
          "name": "pteridine-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042558"
              ],
              "previous": [
                "GO:0042558",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042726",
          "name": "flavin-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0042727",
          "name": "flavin-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0042726"
              ],
              "previous": [
                "GO:0042726",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042728",
          "name": "flavin-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0042726"
              ],
              "previous": [
                "GO:0042726",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042860",
          "name": "achromobactin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009237",
                "GO:0019752",
                "GO:0043603",
                "GO:1901615"
              ],
              "previous": [
                "GO:0009237",
                "GO:0019752",
                "GO:0043603",
                "GO:1901564",
                "GO:1901615"
              ]
            }
          }
        },
        {
          "id": "GO:0042861",
          "name": "achromobactin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019290",
                "GO:0042860",
                "GO:0043604",
                "GO:0046394",
                "GO:1901617"
              ],
              "previous": [
                "GO:0019290",
                "GO:0042860",
                "GO:0043604",
                "GO:0046394",
                "GO:1901566",
                "GO:1901617"
              ]
            }
          }
        },
        {
          "id": "GO:0042862",
          "name": "achromobactin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042860",
                "GO:0046215",
                "GO:0046395",
                "GO:1901616"
              ],
              "previous": [
                "GO:0042860",
                "GO:0046215",
                "GO:0046395",
                "GO:1901565",
                "GO:1901616"
              ]
            }
          }
        },
        {
          "id": "GO:0042863",
          "name": "pyochelin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0009237",
                "GO:0018958",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006790",
                "GO:0009237",
                "GO:0018958",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0042864",
          "name": "pyochelin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019290",
                "GO:0042863",
                "GO:0044272",
                "GO:0046189",
                "GO:0046394"
              ],
              "previous": [
                "GO:0019290",
                "GO:0042863",
                "GO:0044272",
                "GO:0046189",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0042865",
          "name": "pyochelin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019336",
                "GO:0042863",
                "GO:0044273",
                "GO:0046215",
                "GO:0046395"
              ],
              "previous": [
                "GO:0019336",
                "GO:0042863",
                "GO:0044273",
                "GO:0046215",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0042983",
          "name": "amyloid precursor protein biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:0042982"
              ],
              "previous": [
                "GO:0009059",
                "GO:0042982",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0043102",
          "name": "amino acid salvage",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008652",
                "GO:0043094",
                "GO:0046394"
              ],
              "previous": [
                "GO:0008652",
                "GO:0043094",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0043201",
          "name": "response to L-leucine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0043279",
          "name": "response to alkaloid",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0043419",
          "name": "urea catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019627",
                "GO:0043605",
                "GO:0044282"
              ],
              "previous": [
                "GO:0019627",
                "GO:0043605",
                "GO:0044282",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0043434",
          "name": "response to peptide hormone",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009725",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0009725",
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0043545",
          "name": "molybdopterin cofactor metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006796",
                "GO:0019637",
                "GO:0051189"
              ],
              "previous": [
                "GO:0006796",
                "GO:0019637",
                "GO:0051189",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0043606",
          "name": "formamide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0043607",
          "name": "formamide biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0043606"
              ],
              "previous": [
                "GO:0043604",
                "GO:0043606",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0043608",
          "name": "formamide catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043605",
                "GO:0043606"
              ],
              "previous": [
                "GO:0043605",
                "GO:0043606",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0043641",
          "name": "novobiocin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009804",
                "GO:0016137",
                "GO:0016999",
                "GO:0018904",
                "GO:0018958",
                "GO:0043603"
              ],
              "previous": [
                "GO:0009804",
                "GO:0016137",
                "GO:0016999",
                "GO:0018904",
                "GO:0018958",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0043642",
          "name": "novobiocin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009805",
                "GO:0016138",
                "GO:0017000",
                "GO:0043604",
                "GO:0043641",
                "GO:0046189",
                "GO:1901503"
              ],
              "previous": [
                "GO:0009805",
                "GO:0016138",
                "GO:0017000",
                "GO:0043604",
                "GO:0043641",
                "GO:0046189",
                "GO:1901503",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0046112",
          "name": "nucleobase biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0009112"
              ],
              "previous": [
                "GO:0009112",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0046113",
          "name": "nucleobase catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0009112"
              ],
              "previous": [
                "GO:0009112",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0046201",
          "name": "cyanate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0009439"
              ],
              "previous": [
                "GO:0009439",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0046232",
          "name": "carbazole catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0018884",
                "GO:0042178"
              ],
              "previous": [
                "GO:0018884",
                "GO:0042178",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0046302",
          "name": "2-chloro-N-isopropylacetanilide catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0018889"
              ],
              "previous": [
                "GO:0018889",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0046380",
          "name": "N-acetylneuraminate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006054",
                "GO:0043604",
                "GO:0046349",
                "GO:0046394"
              ],
              "previous": [
                "GO:0006054",
                "GO:0043604",
                "GO:0046349",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0046450",
          "name": "dethiobiotin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032787",
                "GO:0043603"
              ],
              "previous": [
                "GO:0032787",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0046451",
          "name": "diaminopimelate metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0043648",
                "GO:1901568"
              ],
              "previous": [
                "GO:0006520",
                "GO:0043648",
                "GO:1901564",
                "GO:1901568"
              ]
            }
          }
        },
        {
          "id": "GO:0046453",
          "name": "dipyrrin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0046469",
          "name": "platelet activating factor metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006650",
                "GO:0046485"
              ],
              "previous": [
                "GO:0006650",
                "GO:0046485",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0046470",
          "name": "phosphatidylcholine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006650"
              ],
              "previous": [
                "GO:0006650",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0046494",
          "name": "rhizobactin 1021 metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009237",
                "GO:0019752",
                "GO:0043603",
                "GO:1902644"
              ],
              "previous": [
                "GO:0009237",
                "GO:0019752",
                "GO:0043603",
                "GO:1901564",
                "GO:1902644"
              ]
            }
          }
        },
        {
          "id": "GO:0046678",
          "name": "response to bacteriocin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046677",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0046677",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0046681",
          "name": "response to carbamate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017085",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0017085",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0046898",
          "name": "response to cycloheximide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0097305",
                "GO:1901654",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0097305",
                "GO:1901654"
              ]
            }
          }
        },
        {
          "id": "GO:0046937",
          "name": "phytochelatin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019748",
                "GO:0043603"
              ],
              "previous": [
                "GO:0019748",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0046938",
          "name": "phytochelatin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0044550",
                "GO:0046937"
              ],
              "previous": [
                "GO:0043604",
                "GO:0044550",
                "GO:0046937",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0048107",
          "name": "4-amino-3-isothiazolidinone biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044272"
              ],
              "previous": [
                "GO:0044272",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0050435",
          "name": "amyloid-beta metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0050761",
          "name": "depsipeptide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0050762",
          "name": "depsipeptide catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0050761"
              ],
              "previous": [
                "GO:0050761",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0050763",
          "name": "depsipeptide biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0050761"
              ],
              "previous": [
                "GO:0043604",
                "GO:0050761",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0050813",
          "name": "epothilone metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0033067",
                "GO:0042180"
              ],
              "previous": [
                "GO:0006790",
                "GO:0033067",
                "GO:0042180",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0050814",
          "name": "epothilone biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033068",
                "GO:0042181",
                "GO:0044272",
                "GO:0050813"
              ],
              "previous": [
                "GO:0033068",
                "GO:0042181",
                "GO:0044272",
                "GO:0050813",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0050898",
          "name": "nitrile metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0050899",
          "name": "nitrile catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0050898"
              ],
              "previous": [
                "GO:0050898",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0051068",
          "name": "dihydrolipoamide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006790",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0051593",
          "name": "response to folic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0052645",
          "name": "F420-0 metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019520",
                "GO:0052648"
              ],
              "previous": [
                "GO:0019520",
                "GO:0052648",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0052649",
          "name": "coenzyme gamma-F420-2 metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0052648",
                "GO:0072350"
              ],
              "previous": [
                "GO:0052648",
                "GO:0072350",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0052704",
          "name": "ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0052699"
              ],
              "previous": [
                "GO:0009072",
                "GO:0052699",
                "GO:0052803",
                "GO:1901605"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "has_part GO:0052707"
              ]
            }
          }
        },
        {
          "id": "GO:0052803",
          "name": "imidazole-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0052805",
          "name": "imidazole-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0052803"
              ],
              "previous": [
                "GO:0052803",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0052837",
          "name": "thiazole biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0018131",
                "GO:0044272",
                "GO:0052838"
              ],
              "previous": [
                "GO:0018131",
                "GO:0044272",
                "GO:0052838",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0052838",
          "name": "thiazole metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0046484"
              ],
              "previous": [
                "GO:0006790",
                "GO:0046484",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0052889",
          "name": "9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene",
          "changes": {
            "relationship": {
              "current": [
                "has_part GO:0016719"
              ],
              "previous": [
                "has_part GO:0052886",
                "has_part GO:0052887"
              ]
            }
          }
        },
        {
          "id": "GO:0055094",
          "name": "response to lipoprotein particle",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009719",
                "GO:1901698"
              ],
              "previous": [
                "GO:0009719",
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0061157",
          "name": "mRNA destabilization",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010629",
                "GO:0043488",
                "GO:0050779",
                "GO:0061014"
              ],
              "previous": [
                "GO:0043488",
                "GO:0050779",
                "GO:0061014"
              ]
            }
          }
        },
        {
          "id": "GO:0061431",
          "name": "cellular response to methionine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0031670",
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1904640"
              ],
              "previous": [
                "GO:0031670",
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1904640"
              ]
            }
          }
        },
        {
          "id": "GO:0061680",
          "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019595",
                "GO:0061679",
                "GO:0061718"
              ],
              "previous": [
                "GO:0005996",
                "GO:0061679"
              ]
            }
          }
        },
        {
          "id": "GO:0061959",
          "name": "response to (R)-carnitine",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0062032",
          "name": "cichorine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044550",
                "GO:0046189"
              ],
              "previous": [
                "GO:0044550",
                "GO:0046189",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0062034",
          "name": "L-pipecolic acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0072330"
              ],
              "previous": [
                "GO:0072330",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0062112",
          "name": "fatty acid primary amide biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0062126",
                "GO:1901570"
              ],
              "previous": [
                "GO:0043604",
                "GO:0062126",
                "GO:1901566",
                "GO:1901570"
              ]
            }
          }
        },
        {
          "id": "GO:0062126",
          "name": "fatty acid primary amide metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:1901568"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564",
                "GO:1901568"
              ]
            }
          }
        },
        {
          "id": "GO:0062127",
          "name": "fatty acid primary amide catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0062126",
                "GO:1901569"
              ],
              "previous": [
                "GO:0062126",
                "GO:1901565",
                "GO:1901569"
              ]
            }
          }
        },
        {
          "id": "GO:0062234",
          "name": "platelet activating factor catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044269",
                "GO:0046469",
                "GO:0046475"
              ],
              "previous": [
                "GO:0044269",
                "GO:0046469",
                "GO:0046475",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0070292",
          "name": "N-acylphosphatidylethanolamine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:0046337"
              ],
              "previous": [
                "GO:0043603",
                "GO:0046337",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0070781",
          "name": "response to biotin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0033273",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0033273",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0071213",
          "name": "cellular response to 1-aminocyclopropane-1-carboxylic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009961",
                "GO:0071230",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0009961",
                "GO:0071230",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071224",
          "name": "cellular response to peptidoglycan",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032494",
                "GO:0071219",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0032494",
                "GO:0071219",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071225",
          "name": "cellular response to muramyl dipeptide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032495",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0032495",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071231",
          "name": "cellular response to folic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0051593",
                "GO:0071295",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0051593",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071232",
          "name": "cellular response to histidine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:0071407",
                "GO:0080052",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071407",
                "GO:0071417",
                "GO:0080052",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071233",
          "name": "cellular response to L-leucine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043201",
                "GO:0071230",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0043201",
                "GO:0071230",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071234",
          "name": "cellular response to phenylalanine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:0071407",
                "GO:0080053",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071407",
                "GO:0071417",
                "GO:0080053",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071235",
          "name": "cellular response to proline",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010238",
                "GO:0071230",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0010238",
                "GO:0071230",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071237",
          "name": "cellular response to bacteriocin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046678",
                "GO:0071236",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0046678",
                "GO:0071236",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071296",
          "name": "cellular response to biotin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0070781",
                "GO:0071295",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0070781",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071297",
          "name": "cellular response to cobalamin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033590",
                "GO:0071295",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0033590",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071301",
          "name": "cellular response to vitamin B1",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010266",
                "GO:0071295",
                "GO:0071407",
                "GO:0097306",
                "GO:1901699"
              ],
              "previous": [
                "GO:0010266",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:0097306"
              ]
            }
          }
        },
        {
          "id": "GO:0071302",
          "name": "cellular response to vitamin B2",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033274",
                "GO:0071295",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0033274",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071304",
          "name": "cellular response to vitamin B6",
          "changes": {
            "is_a": {
              "current": [
                "GO:0034516",
                "GO:0071295",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0034516",
                "GO:0071295",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071312",
          "name": "cellular response to alkaloid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043279",
                "GO:1901699"
              ],
              "previous": [
                "GO:0043279",
                "GO:0071417"
              ]
            }
          }
        },
        {
          "id": "GO:0071318",
          "name": "cellular response to ATP",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033198",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0033198",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071320",
          "name": "cellular response to cAMP",
          "changes": {
            "is_a": {
              "current": [
                "GO:0051591",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0051591",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071321",
          "name": "cellular response to cGMP",
          "changes": {
            "is_a": {
              "current": [
                "GO:0070305",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0070305",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071323",
          "name": "cellular response to chitin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010200",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0010200",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071366",
          "name": "cellular response to indolebutyric acid stimulus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071365",
                "GO:0071407",
                "GO:0080026",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071365",
                "GO:0071407",
                "GO:0071417",
                "GO:0080026",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071375",
          "name": "cellular response to peptide hormone stimulus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032870",
                "GO:0043434",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0032870",
                "GO:0043434",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071409",
          "name": "cellular response to cycloheximide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046898",
                "GO:0071407",
                "GO:0097306",
                "GO:1901655",
                "GO:1901699"
              ],
              "previous": [
                "GO:0046898",
                "GO:0071407",
                "GO:0071417",
                "GO:0097306",
                "GO:1901655"
              ]
            }
          }
        },
        {
          "id": "GO:0071414",
          "name": "cellular response to methotrexate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0031427",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0031427",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071415",
          "name": "cellular response to purine-containing compound",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014074",
                "GO:0071407",
                "GO:1901699"
              ],
              "previous": [
                "GO:0014074",
                "GO:0071407",
                "GO:0071417"
              ]
            }
          }
        },
        {
          "id": "GO:0071418",
          "name": "cellular response to amine stimulus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014075",
                "GO:1901699"
              ],
              "previous": [
                "GO:0014075",
                "GO:0071417"
              ]
            }
          }
        },
        {
          "id": "GO:0071420",
          "name": "cellular response to histamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0034776",
                "GO:0071407",
                "GO:1901699"
              ],
              "previous": [
                "GO:0034776",
                "GO:0071407",
                "GO:0071417"
              ]
            }
          }
        },
        {
          "id": "GO:0071503",
          "name": "response to heparin",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0071504",
          "name": "cellular response to heparin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071503",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071417",
                "GO:0071503",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0071680",
          "name": "response to indole-3-methanol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0097305",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0097305"
              ]
            }
          }
        },
        {
          "id": "GO:0071681",
          "name": "cellular response to indole-3-methanol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0071680",
                "GO:0097306",
                "GO:1901699"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0071680",
                "GO:0097306"
              ]
            }
          }
        },
        {
          "id": "GO:0071867",
          "name": "response to monoamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0071868",
          "name": "cellular response to monoamine stimulus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071867",
                "GO:1901699"
              ],
              "previous": [
                "GO:0071417",
                "GO:0071867"
              ]
            }
          }
        },
        {
          "id": "GO:0072338",
          "name": "lactam metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603",
                "GO:0044281"
              ],
              "previous": [
                "GO:0043603",
                "GO:0044281",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0072339",
          "name": "lactam biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:0072338"
              ],
              "previous": [
                "GO:0043604",
                "GO:0072338",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0072340",
          "name": "lactam catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0072338"
              ],
              "previous": [
                "GO:0072338",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0072521",
          "name": "purine-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0072522",
          "name": "purine-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0072521"
              ],
              "previous": [
                "GO:0072521",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0072523",
          "name": "purine-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0072521"
              ],
              "previous": [
                "GO:0072521",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0072524",
          "name": "pyridine-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0072525",
          "name": "pyridine-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0072524"
              ],
              "previous": [
                "GO:0072524",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0072526",
          "name": "pyridine-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0072524"
              ],
              "previous": [
                "GO:0072524",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0072527",
          "name": "pyrimidine-containing compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0072528",
          "name": "pyrimidine-containing compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0072527"
              ],
              "previous": [
                "GO:0072527",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0072529",
          "name": "pyrimidine-containing compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:0072527"
              ],
              "previous": [
                "GO:0072527",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0072712",
          "name": "response to thiabendazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0072713",
          "name": "cellular response to thiabendazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0072712",
                "GO:1901699"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0072712"
              ]
            }
          }
        },
        {
          "id": "GO:0072716",
          "name": "response to actinomycin D",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046677",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0046677",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0072717",
          "name": "cellular response to actinomycin D",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071236",
                "GO:0072716",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071236",
                "GO:0071417",
                "GO:0072716",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072722",
          "name": "response to amitrole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0072723",
          "name": "cellular response to amitrole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0072722",
                "GO:1901699"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0072722"
              ]
            }
          }
        },
        {
          "id": "GO:0072724",
          "name": "response to 4-nitroquinoline N-oxide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0072725",
          "name": "cellular response to 4-nitroquinoline N-oxide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0072724",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0072724",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072739",
          "name": "response to anisomycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042221"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:0072740",
          "name": "cellular response to anisomycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0072739"
              ],
              "previous": [
                "GO:0071417",
                "GO:0072739"
              ]
            }
          }
        },
        {
          "id": "GO:0072745",
          "name": "cellular response to antimycin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901325",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901325",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072747",
          "name": "cellular response to chloramphenicol",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901322",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901322",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072748",
          "name": "cellular response to tacrolimus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901327",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901327",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072749",
          "name": "cellular response to cytochalasin B",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901328",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901328",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072751",
          "name": "cellular response to L-thialysine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901345",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901345",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072752",
          "name": "cellular response to rapamycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071362",
                "GO:0071407",
                "GO:0097306",
                "GO:1901355",
                "GO:1901655",
                "GO:1901699"
              ],
              "previous": [
                "GO:0071362",
                "GO:0071407",
                "GO:0071417",
                "GO:0097306",
                "GO:1901355",
                "GO:1901655"
              ]
            }
          }
        },
        {
          "id": "GO:0072753",
          "name": "cellular response to glutathione",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901370",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901370",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072761",
          "name": "cellular response to capsazepine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901594",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901594",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0072762",
          "name": "cellular response to carbendazim",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901597",
                "GO:1901699",
                "GO:1901701"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901597",
                "GO:1901701"
              ]
            }
          }
        },
        {
          "id": "GO:0080026",
          "name": "response to indolebutyric acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009733",
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0009733",
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0080028",
          "name": "nitrile biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:0050898"
              ],
              "previous": [
                "GO:0050898",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0080052",
          "name": "response to histidine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0080053",
          "name": "response to phenylalanine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0080088",
          "name": "spermidine hydroxycinnamate conjugate biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604"
              ],
              "previous": [
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0090293",
          "name": "nitrogen catabolite regulation of transcription",
          "changes": {
            "relationship": {
              "current": "N/A",
              "previous": [
                "part_of GO:0071417"
              ]
            }
          }
        },
        {
          "id": "GO:0097222",
          "name": "mitochondrial mRNA polyadenylation",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000963"
              ],
              "previous": [
                "GO:0090646"
              ]
            }
          }
        },
        {
          "id": "GO:0097250",
          "name": "mitochondrial respirasome assembly",
          "changes": {
            "relationship": {
              "current": [
                "occurs_in GO:0005739"
              ],
              "previous": "N/A"
            }
          }
        },
        {
          "id": "GO:0097289",
          "name": "alpha-ribazole metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901657"
              ],
              "previous": [
                "GO:1901564",
                "GO:1901657"
              ]
            }
          }
        },
        {
          "id": "GO:0097330",
          "name": "response to 5-fluoro-2'-deoxyuridine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0097331",
          "name": "response to cytarabine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1903416"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1903416"
              ]
            }
          }
        },
        {
          "id": "GO:0097333",
          "name": "response to olanzapine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0097334",
          "name": "response to perphenazine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0097305",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0097305"
              ]
            }
          }
        },
        {
          "id": "GO:0097335",
          "name": "response to quetiapine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0097336",
          "name": "response to risperidone",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:0097337",
          "name": "response to ziprasidone",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0097338",
          "name": "response to clozapine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:0098963",
          "name": "dendritic transport of messenger ribonucleoprotein complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0098935"
              ],
              "previous": [
                "GO:0098961"
              ]
            }
          }
        },
        {
          "id": "GO:0098964",
          "name": "anterograde dendritic transport of messenger ribonucleoprotein complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0098937"
              ],
              "previous": [
                "GO:0098937",
                "GO:0098963"
              ]
            }
          }
        },
        {
          "id": "GO:0099087",
          "name": "anterograde axonal transport of messenger ribonucleoprotein complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008089"
              ],
              "previous": [
                "GO:0008089",
                "GO:0099088"
              ]
            }
          }
        },
        {
          "id": "GO:0099088",
          "name": "axonal transport of messenger ribonucleoprotein complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0098930"
              ],
              "previous": [
                "GO:0031503",
                "GO:0098930"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "occurs_in GO:1904115"
              ]
            }
          }
        },
        {
          "id": "GO:0106220",
          "name": "pyocyanine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058"
              ],
              "previous": [
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0120174",
          "name": "stress-induced homeostatically regulated protein degradation pathway",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033554",
                "GO:0043161",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0033554",
                "GO:0043161"
              ]
            }
          }
        },
        {
          "id": "GO:0140380",
          "name": "psilocybin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006568",
                "GO:0006796",
                "GO:0035835",
                "GO:0042435",
                "GO:0043386",
                "GO:0090407"
              ],
              "previous": [
                "GO:0006568",
                "GO:0006796",
                "GO:0035835",
                "GO:0042435",
                "GO:0043386",
                "GO:0090407",
                "GO:1902221"
              ]
            }
          }
        },
        {
          "id": "GO:0140604",
          "name": "mycofactocin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058"
              ],
              "previous": [
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0140872",
          "name": "viridicatumtoxin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0030639",
                "GO:0042181",
                "GO:0043386",
                "GO:0043604",
                "GO:0046189",
                "GO:0120255",
                "GO:1901503",
                "GO:1902645",
                "GO:1902653"
              ],
              "previous": [
                "GO:0030639",
                "GO:0042181",
                "GO:0043386",
                "GO:0043604",
                "GO:0046189",
                "GO:0120255",
                "GO:1901503",
                "GO:1901566",
                "GO:1902645",
                "GO:1902653"
              ]
            }
          }
        },
        {
          "id": "GO:0141005",
          "name": "retrotransposon silencing by heterochromatin formation",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010526",
                "GO:0031507"
              ],
              "previous": [
                "GO:0010526"
              ]
            }
          }
        },
        {
          "id": "GO:0141008",
          "name": "retrotransposon silencing by mRNA destabilization",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010526",
                "GO:0061157"
              ],
              "previous": [
                "GO:0010526"
              ]
            }
          }
        },
        {
          "id": "GO:0170038",
          "name": "proteinogenic amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046394",
                "GO:0170039"
              ],
              "previous": [
                "GO:0046394",
                "GO:0170039",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0170039",
          "name": "proteinogenic amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0170040",
          "name": "proteinogenic amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046395",
                "GO:0170039"
              ],
              "previous": [
                "GO:0046395",
                "GO:0170039",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:0170041",
          "name": "non-proteinogenic amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:0170043",
          "name": "non-proteinogenic amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046394",
                "GO:0170041"
              ],
              "previous": [
                "GO:0046394",
                "GO:0170041",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:0170044",
          "name": "non-proteinogenic amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046395",
                "GO:0170041"
              ],
              "previous": [
                "GO:0046395",
                "GO:0170041",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1900549",
          "name": "N',N'',N'''-triacetylfusarinine C metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019748"
              ],
              "previous": [
                "GO:0019748",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1900550",
          "name": "N',N'',N'''-triacetylfusarinine C catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090487",
                "GO:1900549"
              ],
              "previous": [
                "GO:0090487",
                "GO:1900549",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1900551",
          "name": "N',N'',N'''-triacetylfusarinine C biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044550",
                "GO:1900549"
              ],
              "previous": [
                "GO:0044550",
                "GO:1900549",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1900603",
          "name": "tensidol A metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019748",
                "GO:0042180",
                "GO:0043603"
              ],
              "previous": [
                "GO:0019748",
                "GO:0042180",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1900604",
          "name": "tensidol A catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042182",
                "GO:0090487",
                "GO:1900603"
              ],
              "previous": [
                "GO:0042182",
                "GO:0090487",
                "GO:1900603",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1900605",
          "name": "tensidol A biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042181",
                "GO:0043604",
                "GO:0044550",
                "GO:1900603"
              ],
              "previous": [
                "GO:0042181",
                "GO:0043604",
                "GO:0044550",
                "GO:1900603",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1900629",
          "name": "methanophenazine metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1900630",
          "name": "methanophenazine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:1900629"
              ],
              "previous": [
                "GO:1900629",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1901103",
          "name": "gramicidin S biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604"
              ],
              "previous": [
                "GO:0043604",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1901122",
          "name": "bacitracin A metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043603"
              ],
              "previous": [
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901123",
          "name": "bacitracin A catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:1901122"
              ],
              "previous": [
                "GO:1901122",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1901124",
          "name": "bacitracin A biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043604",
                "GO:1901122"
              ],
              "previous": [
                "GO:0043604",
                "GO:1901122",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1901160",
          "name": "primary amino compound metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901161",
          "name": "primary amino compound catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:1901160"
              ],
              "previous": [
                "GO:1901160",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1901162",
          "name": "primary amino compound biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:1901160"
              ],
              "previous": [
                "GO:1901160",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1901281",
          "name": "fructoselysine catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0030392",
                "GO:0030393",
                "GO:0046395"
              ],
              "previous": [
                "GO:0030392",
                "GO:0030393",
                "GO:0046395",
                "GO:1901565"
              ]
            }
          }
        },
        {
          "id": "GO:1901282",
          "name": "fructoselysine biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0030391",
                "GO:0030393",
                "GO:0046394"
              ],
              "previous": [
                "GO:0030391",
                "GO:0030393",
                "GO:0046394",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:1901322",
          "name": "response to chloramphenicol",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901325",
          "name": "response to antimycin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901327",
          "name": "response to tacrolimus",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901328",
          "name": "response to cytochalasin B",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901345",
          "name": "response to L-thialysine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901354",
          "name": "response to L-canavanine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901355",
          "name": "response to rapamycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0045472",
                "GO:0097305",
                "GO:1901654",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0045472",
                "GO:0097305",
                "GO:1901654"
              ]
            }
          }
        },
        {
          "id": "GO:1901367",
          "name": "response to L-cysteine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901370",
          "name": "response to glutathione",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901554",
          "name": "response to paracetamol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901556",
          "name": "response to candesartan",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901558",
          "name": "response to metformin",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1901559",
          "name": "response to ribavirin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901594",
          "name": "response to capsazepine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901597",
          "name": "response to carbendazim",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1901605",
          "name": "alpha-amino acid metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006520",
                "GO:0019752"
              ],
              "previous": [
                "GO:0006520",
                "GO:0019752",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901606",
          "name": "alpha-amino acid catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009063",
                "GO:0046395",
                "GO:1901605"
              ],
              "previous": [
                "GO:0009063",
                "GO:0046395",
                "GO:1901565",
                "GO:1901605"
              ]
            }
          }
        },
        {
          "id": "GO:1901607",
          "name": "alpha-amino acid biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008652",
                "GO:0046394",
                "GO:1901605"
              ],
              "previous": [
                "GO:0008652",
                "GO:0046394",
                "GO:1901566",
                "GO:1901605"
              ]
            }
          }
        },
        {
          "id": "GO:1901664",
          "name": "regulation of NAD+ ADP-ribosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010835"
              ],
              "previous": [
                "GO:0051338"
              ]
            }
          }
        },
        {
          "id": "GO:1901665",
          "name": "negative regulation of NAD+ ADP-ribosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010836",
                "GO:1901664"
              ],
              "previous": [
                "GO:0051348",
                "GO:1901664"
              ]
            }
          }
        },
        {
          "id": "GO:1901685",
          "name": "glutathione derivative metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790"
              ],
              "previous": [
                "GO:0006790",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901686",
          "name": "glutathione derivative catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044273",
                "GO:1901685"
              ],
              "previous": [
                "GO:0044273",
                "GO:1901565",
                "GO:1901685"
              ]
            }
          }
        },
        {
          "id": "GO:1901687",
          "name": "glutathione derivative biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0044272",
                "GO:1901685"
              ],
              "previous": [
                "GO:0044272",
                "GO:1901566",
                "GO:1901685"
              ]
            }
          }
        },
        {
          "id": "GO:1901748",
          "name": "leukotriene D4 metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006691",
                "GO:0006790",
                "GO:0043603",
                "GO:1901568"
              ],
              "previous": [
                "GO:0006691",
                "GO:0006790",
                "GO:0043603",
                "GO:1901564",
                "GO:1901568"
              ]
            }
          }
        },
        {
          "id": "GO:1901749",
          "name": "leukotriene D4 catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0036100",
                "GO:0044273",
                "GO:1901523",
                "GO:1901748"
              ],
              "previous": [
                "GO:0036100",
                "GO:0044273",
                "GO:1901523",
                "GO:1901565",
                "GO:1901748"
              ]
            }
          }
        },
        {
          "id": "GO:1901750",
          "name": "leukotriene D4 biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0019370",
                "GO:0043604",
                "GO:0044272",
                "GO:1901570",
                "GO:1901748"
              ],
              "previous": [
                "GO:0019370",
                "GO:0043604",
                "GO:0044272",
                "GO:1901566",
                "GO:1901570",
                "GO:1901748"
              ]
            }
          }
        },
        {
          "id": "GO:1901775",
          "name": "mitomycin C metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042180"
              ],
              "previous": [
                "GO:0042180",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901776",
          "name": "mitomycin C catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042182",
                "GO:1901775"
              ],
              "previous": [
                "GO:0042182",
                "GO:1901565",
                "GO:1901775"
              ]
            }
          }
        },
        {
          "id": "GO:1901777",
          "name": "mitomycin C biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0042181",
                "GO:1901775"
              ],
              "previous": [
                "GO:0042181",
                "GO:1901566",
                "GO:1901775"
              ]
            }
          }
        },
        {
          "id": "GO:1901850",
          "name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008152"
              ],
              "previous": [
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:1901851",
          "name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009056",
                "GO:1901850"
              ],
              "previous": [
                "GO:1901565",
                "GO:1901850"
              ]
            }
          }
        },
        {
          "id": "GO:1901852",
          "name": "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009058",
                "GO:1901850"
              ],
              "previous": [
                "GO:1901566",
                "GO:1901850"
              ]
            }
          }
        },
        {
          "id": "GO:1901986",
          "name": "response to ketamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901654",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901654"
              ]
            }
          }
        },
        {
          "id": "GO:1902065",
          "name": "response to L-glutamate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1902349",
          "name": "response to chloroquine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:1902350",
          "name": "cellular response to chloroquine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1902349"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1902349"
              ]
            }
          }
        },
        {
          "id": "GO:1902351",
          "name": "response to imidacloprid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:1902518",
          "name": "response to cyclophosphamide",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1903493",
          "name": "response to clopidogrel",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1903576",
          "name": "response to L-arginine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1903577",
          "name": "cellular response to L-arginine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1903576"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1903576"
              ]
            }
          }
        },
        {
          "id": "GO:1903605",
          "name": "cytochrome biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0009059",
                "GO:1903604"
              ],
              "previous": [
                "GO:0009059",
                "GO:1901566",
                "GO:1903604"
              ]
            }
          }
        },
        {
          "id": "GO:1903937",
          "name": "response to acrylamide",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1903938",
          "name": "cellular response to acrylamide",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1903937"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1903937"
              ]
            }
          }
        },
        {
          "id": "GO:1903967",
          "name": "response to micafungin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033993",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0033993",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1903968",
          "name": "cellular response to micafungin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071396",
                "GO:1901699",
                "GO:1901701",
                "GO:1903967"
              ],
              "previous": [
                "GO:0071396",
                "GO:0071417",
                "GO:1901701",
                "GO:1903967"
              ]
            }
          }
        },
        {
          "id": "GO:1904101",
          "name": "response to acadesine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904102",
          "name": "cellular response to acadesine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1904101"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1904101"
              ]
            }
          }
        },
        {
          "id": "GO:1904307",
          "name": "response to desipramine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:1904308",
          "name": "cellular response to desipramine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1904307"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1904307"
              ]
            }
          }
        },
        {
          "id": "GO:1904310",
          "name": "cellular response to cordycepin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1904309"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1904309"
              ]
            }
          }
        },
        {
          "id": "GO:1904316",
          "name": "response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033993",
                "GO:0045472",
                "GO:0046683",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0033993",
                "GO:0045472",
                "GO:0046683"
              ]
            }
          }
        },
        {
          "id": "GO:1904317",
          "name": "cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071362",
                "GO:0071396",
                "GO:1901699",
                "GO:1904316"
              ],
              "previous": [
                "GO:0071362",
                "GO:0071396",
                "GO:0071417",
                "GO:1904316"
              ]
            }
          }
        },
        {
          "id": "GO:1904373",
          "name": "response to kainic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904374",
          "name": "cellular response to kainic acid",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1904373"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1904373"
              ]
            }
          }
        },
        {
          "id": "GO:1904386",
          "name": "response to L-phenylalanine derivative",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1904387",
          "name": "cellular response to L-phenylalanine derivative",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1904386"
              ],
              "previous": [
                "GO:0071417",
                "GO:1904386"
              ]
            }
          }
        },
        {
          "id": "GO:1904391",
          "name": "response to ciliary neurotrophic factor",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1904392",
          "name": "cellular response to ciliary neurotrophic factor",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1904391"
              ],
              "previous": [
                "GO:0071417",
                "GO:1904391"
              ]
            }
          }
        },
        {
          "id": "GO:1904402",
          "name": "response to nocodazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901654",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901654"
              ]
            }
          }
        },
        {
          "id": "GO:1904403",
          "name": "cellular response to nocodazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901655",
                "GO:1901699",
                "GO:1904402"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901655",
                "GO:1904402"
              ]
            }
          }
        },
        {
          "id": "GO:1904481",
          "name": "response to tetrahydrofolate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904482",
          "name": "cellular response to tetrahydrofolate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1904481"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1904481"
              ]
            }
          }
        },
        {
          "id": "GO:1904560",
          "name": "response to diphenidol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0097305",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0097305"
              ]
            }
          }
        },
        {
          "id": "GO:1904561",
          "name": "cellular response to diphenidol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0097306",
                "GO:1901699",
                "GO:1904560"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0097306",
                "GO:1904560"
              ]
            }
          }
        },
        {
          "id": "GO:1904583",
          "name": "response to polyamine macromolecule",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1904584",
          "name": "cellular response to polyamine macromolecule",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1904583"
              ],
              "previous": [
                "GO:0071417",
                "GO:1904583"
              ]
            }
          }
        },
        {
          "id": "GO:1904585",
          "name": "response to putrescine",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243"
              ]
            }
          }
        },
        {
          "id": "GO:1904586",
          "name": "cellular response to putrescine",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1904585"
              ],
              "previous": [
                "GO:0071417",
                "GO:1904585"
              ]
            }
          }
        },
        {
          "id": "GO:1904587",
          "name": "response to glycoprotein",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904588",
          "name": "cellular response to glycoprotein",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1904587"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1904587"
              ]
            }
          }
        },
        {
          "id": "GO:1904640",
          "name": "response to methionine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904645",
          "name": "response to amyloid-beta",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904646",
          "name": "cellular response to amyloid-beta",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1904645"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1904645"
              ]
            }
          }
        },
        {
          "id": "GO:1904844",
          "name": "response to L-glutamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904845",
          "name": "cellular response to L-glutamine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1904844"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1904844"
              ]
            }
          }
        },
        {
          "id": "GO:1904975",
          "name": "response to bleomycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1904976",
          "name": "cellular response to bleomycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1904975"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1904975"
              ]
            }
          }
        },
        {
          "id": "GO:1905119",
          "name": "response to haloperidol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0097305",
                "GO:1901654",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0097305",
                "GO:1901654"
              ]
            }
          }
        },
        {
          "id": "GO:1905120",
          "name": "cellular response to haloperidol",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:0097306",
                "GO:1901655",
                "GO:1901699",
                "GO:1905119"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:0097306",
                "GO:1901655",
                "GO:1905119"
              ]
            }
          }
        },
        {
          "id": "GO:1905232",
          "name": "cellular response to L-glutamate",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1902065"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1902065"
              ]
            }
          }
        },
        {
          "id": "GO:1905237",
          "name": "response to cyclosporin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905238",
          "name": "cellular response to cyclosporin A",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1905237"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1905237"
              ]
            }
          }
        },
        {
          "id": "GO:1905242",
          "name": "response to 3,3',5-triiodo-L-thyronine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905243",
          "name": "cellular response to 3,3',5-triiodo-L-thyronine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1905242"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1905242"
              ]
            }
          }
        },
        {
          "id": "GO:1905307",
          "name": "response to miconazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070"
              ]
            }
          }
        },
        {
          "id": "GO:1905308",
          "name": "cellular response to miconazole",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1905307"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1905307"
              ]
            }
          }
        },
        {
          "id": "GO:1905318",
          "name": "meiosis I spindle assembly checkpoint signaling",
          "changes": {
            "relationship": {
              "current": "N/A",
              "previous": [
                "negatively_regulates GO:0051755"
              ]
            }
          }
        },
        {
          "id": "GO:1905374",
          "name": "response to homocysteine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905375",
          "name": "cellular response to homocysteine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1905374"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1905374"
              ]
            }
          }
        },
        {
          "id": "GO:1905429",
          "name": "response to glycine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043200",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0043200",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905430",
          "name": "cellular response to glycine",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071230",
                "GO:1901699",
                "GO:1901701",
                "GO:1905429"
              ],
              "previous": [
                "GO:0071230",
                "GO:0071417",
                "GO:1901701",
                "GO:1905429"
              ]
            }
          }
        },
        {
          "id": "GO:1905439",
          "name": "response to chondroitin 6'-sulfate",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905440",
          "name": "cellular response to chondroitin 6'-sulfate",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1905439"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1905439"
              ]
            }
          }
        },
        {
          "id": "GO:1905441",
          "name": "response to chondroitin 4'-sulfate",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905442",
          "name": "cellular response to chondroitin 4'-sulfate",
          "changes": {
            "is_a": {
              "current": [
                "GO:1901699",
                "GO:1901701",
                "GO:1905441"
              ],
              "previous": [
                "GO:0071417",
                "GO:1901701",
                "GO:1905441"
              ]
            }
          }
        },
        {
          "id": "GO:1905795",
          "name": "cellular response to puromycin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1905794"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1905794"
              ]
            }
          }
        },
        {
          "id": "GO:1905834",
          "name": "response to pyrimidine ribonucleotide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:0046683",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:0046683",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1905835",
          "name": "cellular response to pyrimidine ribonucleotide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0071407",
                "GO:1901699",
                "GO:1901701",
                "GO:1905834"
              ],
              "previous": [
                "GO:0071407",
                "GO:0071417",
                "GO:1901701",
                "GO:1905834"
              ]
            }
          }
        },
        {
          "id": "GO:1990054",
          "name": "response to temozolomide",
          "changes": {
            "is_a": {
              "current": [
                "GO:0014070",
                "GO:1901698",
                "GO:1901700"
              ],
              "previous": [
                "GO:0010243",
                "GO:0014070",
                "GO:1901700"
              ]
            }
          }
        },
        {
          "id": "GO:1990700",
          "name": "nucleolar chromatin organization",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006325"
              ],
              "previous": [
                "GO:0016043"
              ]
            }
          }
        },
        {
          "id": "GO:2001121",
          "name": "coenzyme gamma-F420-2 biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0052649",
                "GO:0072351",
                "GO:0090407",
                "GO:1901137"
              ],
              "previous": [
                "GO:0052649",
                "GO:0072351",
                "GO:0090407",
                "GO:1901137",
                "GO:1901566"
              ]
            }
          }
        },
        {
          "id": "GO:2001308",
          "name": "gliotoxin metabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0006790",
                "GO:0043385",
                "GO:0043603"
              ],
              "previous": [
                "GO:0006790",
                "GO:0043385",
                "GO:0043603",
                "GO:1901564"
              ]
            }
          }
        },
        {
          "id": "GO:2001309",
          "name": "gliotoxin catabolic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043387",
                "GO:0044273",
                "GO:0051410",
                "GO:2001308"
              ],
              "previous": [
                "GO:0043387",
                "GO:0044273",
                "GO:0051410",
                "GO:1901565",
                "GO:2001308"
              ]
            }
          }
        },
        {
          "id": "GO:2001310",
          "name": "gliotoxin biosynthetic process",
          "changes": {
            "is_a": {
              "current": [
                "GO:0043386",
                "GO:0043604",
                "GO:0044272",
                "GO:2001308"
              ],
              "previous": [
                "GO:0043386",
                "GO:0043604",
                "GO:0044272",
                "GO:1901566",
                "GO:2001308"
              ]
            }
          }
        }
      ],
      "cellular_component": [
        {
          "id": "GO:0000148",
          "name": "1,3-beta-D-glucan synthase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:1990234"
              ],
              "previous": [
                "GO:0098797",
                "GO:1990234"
              ]
            }
          }
        },
        {
          "id": "GO:0009319",
          "name": "cytochrome o ubiquinol oxidase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0070069",
                "GO:0098803",
                "GO:1902495",
                "GO:1990204"
              ],
              "previous": [
                "GO:0070069",
                "GO:1902495",
                "GO:1990204"
              ]
            }
          }
        },
        {
          "id": "GO:0009321",
          "name": "alkyl hydroperoxide reductase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032991"
              ],
              "previous": [
                "GO:1990204"
              ]
            }
          }
        },
        {
          "id": "GO:0009390",
          "name": "dimethyl sulfoxide reductase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032991"
              ],
              "previous": [
                "GO:1990204"
              ]
            }
          }
        },
        {
          "id": "GO:0030874",
          "name": "nucleolar chromatin",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000785",
                "GO:0140513"
              ],
              "previous": [
                "GO:0110165"
              ]
            },
            "relationship": {
              "current": [
                "part_of GO:0000228",
                "part_of GO:0005730"
              ],
              "previous": [
                "part_of GO:0000228",
                "part_of GO:0000785",
                "part_of GO:0005730"
              ]
            }
          }
        },
        {
          "id": "GO:0042765",
          "name": "GPI-anchor transamidase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008303",
                "GO:0098796",
                "GO:0140534",
                "GO:1990234"
              ],
              "previous": [
                "GO:0008303",
                "GO:0098796",
                "GO:0140534"
              ]
            }
          }
        },
        {
          "id": "GO:0044799",
          "name": "NarGHI complex",
          "changes": {
            "relationship": {
              "current": "N/A",
              "previous": [
                "part_of GO:0070470"
              ]
            }
          }
        },
        {
          "id": "GO:0045259",
          "name": "proton-transporting ATP synthase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016469",
                "GO:0034703",
                "GO:0098803",
                "GO:1902494"
              ],
              "previous": [
                "GO:0016469",
                "GO:0034703",
                "GO:1902494"
              ]
            }
          }
        },
        {
          "id": "GO:0045273",
          "name": "respiratory chain complex II (succinate dehydrogenase)",
          "changes": {
            "is_a": {
              "current": [
                "GO:0098796",
                "GO:0098803",
                "GO:1990204"
              ],
              "previous": [
                "GO:0098803",
                "GO:1990204"
              ]
            }
          }
        },
        {
          "id": "GO:0045283",
          "name": "fumarate reductase complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0098796",
                "GO:0098803",
                "GO:1902494"
              ],
              "previous": [
                "GO:0098803",
                "GO:1902494"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "part_of GO:0045273"
              ]
            }
          }
        },
        {
          "id": "GO:0098803",
          "name": "respiratory chain complex",
          "changes": {
            "is_a": {
              "current": [
                "GO:0032991"
              ],
              "previous": [
                "GO:0098796"
              ]
            },
            "relationship": {
              "current": "N/A",
              "previous": [
                "part_of GO:0070469"
              ]
            },
            "intersection_of": {
              "current": "N/A",
              "previous": [
                "is_a GO:0032991",
                "part_of GO:0070469"
              ]
            }
          }
        }
      ],
      "molecular_function": [
        {
          "id": "GO:0002952",
          "name": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016861"
              ],
              "previous": [
                "GO:0016853"
              ]
            }
          }
        },
        {
          "id": "GO:0003912",
          "name": "DNA nucleotidylexotransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0034061"
              ],
              "previous": [
                "GO:0016779",
                "GO:0140097"
              ]
            }
          }
        },
        {
          "id": "GO:0003923",
          "name": "GPI-anchor transamidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004197",
                "GO:0016769"
              ],
              "previous": [
                "GO:0004197"
              ]
            }
          }
        },
        {
          "id": "GO:0003939",
          "name": "L-iditol 2-dehydrogenase (NAD+) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004022"
              ],
              "previous": [
                "GO:0016616"
              ]
            }
          }
        },
        {
          "id": "GO:0003950",
          "name": "NAD+-protein poly-ADP-ribosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:1990404"
              ],
              "previous": [
                "GO:0016763"
              ]
            }
          }
        },
        {
          "id": "GO:0004077",
          "name": "biotin--[biotin carboxyl-carrier protein] ligase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016879",
                "GO:0140096"
              ],
              "previous": [
                "GO:0018271"
              ]
            }
          }
        },
        {
          "id": "GO:0004090",
          "name": "carbonyl reductase (NADPH) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004033"
              ],
              "previous": [
                "GO:0016616"
              ]
            }
          }
        },
        {
          "id": "GO:0004336",
          "name": "galactosylceramidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017042"
              ],
              "previous": [
                "GO:0004553"
              ]
            }
          }
        },
        {
          "id": "GO:0004339",
          "name": "glucan 1,4-alpha-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0004348",
          "name": "glucosylceramidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0017042"
              ],
              "previous": [
                "GO:0004553"
              ]
            }
          }
        },
        {
          "id": "GO:0004373",
          "name": "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033840",
                "GO:0035251"
              ],
              "previous": [
                "GO:0035251"
              ]
            }
          }
        },
        {
          "id": "GO:0004378",
          "name": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000033",
                "GO:0004376"
              ],
              "previous": [
                "GO:0004376"
              ]
            }
          }
        },
        {
          "id": "GO:0004467",
          "name": "long-chain fatty acid-CoA ligase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120515"
              ],
              "previous": [
                "GO:0015645",
                "GO:0016405"
              ]
            }
          }
        },
        {
          "id": "GO:0004573",
          "name": "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0004622",
          "name": "lysophospholipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0004620",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0004623",
          "name": "phospholipase A2 activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0004620",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0004720",
          "name": "protein-lysine 6-oxidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0052597",
                "GO:0140096"
              ],
              "previous": [
                "GO:0016641",
                "GO:0140096"
              ]
            }
          }
        },
        {
          "id": "GO:0004771",
          "name": "sterol ester esterase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016298"
              ],
              "previous": [
                "GO:0016298",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0004806",
          "name": "triacylglycerol lipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016298"
              ],
              "previous": [
                "GO:0016298",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0004838",
          "name": "L-tyrosine-2-oxoglutarate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008793"
              ],
              "previous": [
                "GO:0070547"
              ]
            }
          }
        },
        {
          "id": "GO:0008427",
          "name": "calcium-dependent protein kinase inhibitor activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0010858",
                "GO:0030291"
              ],
              "previous": [
                "GO:0004860",
                "GO:0010858"
              ]
            }
          }
        },
        {
          "id": "GO:0008458",
          "name": "carnitine O-octanoyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016406",
                "GO:0016415"
              ],
              "previous": [
                "GO:0016406",
                "GO:0016414"
              ]
            }
          }
        },
        {
          "id": "GO:0008700",
          "name": "(R,S)-4-hydroxy-2-oxoglutarate aldolase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016833"
              ],
              "previous": [
                "GO:0016832",
                "GO:0016833"
              ]
            }
          }
        },
        {
          "id": "GO:0008970",
          "name": "phospholipase A1 activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0004620",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0009011",
          "name": "alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033840"
              ],
              "previous": [
                "GO:0046527"
              ]
            }
          }
        },
        {
          "id": "GO:0009931",
          "name": "calcium-dependent protein serine/threonine kinase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004674"
              ],
              "previous": [
                "GO:0004674",
                "GO:0010857"
              ]
            }
          }
        },
        {
          "id": "GO:0016212",
          "name": "kynurenine-oxoglutarate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008483"
              ],
              "previous": [
                "GO:0036137"
              ]
            }
          }
        },
        {
          "id": "GO:0016298",
          "name": "lipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0052689"
              ],
              "previous": [
                "GO:0016788"
              ]
            }
          }
        },
        {
          "id": "GO:0031955",
          "name": "short-chain fatty acid-CoA ligase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120515"
              ],
              "previous": [
                "GO:0015645",
                "GO:0016405"
              ]
            }
          }
        },
        {
          "id": "GO:0031956",
          "name": "medium-chain fatty acid-CoA ligase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120515"
              ],
              "previous": [
                "GO:0015645",
                "GO:0016405"
              ]
            }
          }
        },
        {
          "id": "GO:0031957",
          "name": "very long-chain fatty acid-CoA ligase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120515"
              ],
              "previous": [
                "GO:0015645",
                "GO:0016405"
              ]
            }
          }
        },
        {
          "id": "GO:0033857",
          "name": "5-diphosphoinositol pentakisphosphate 1-kinase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000829"
              ],
              "previous": [
                "GO:0180030"
              ]
            }
          }
        },
        {
          "id": "GO:0033878",
          "name": "hormone-sensitive lipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016298"
              ],
              "previous": [
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0033913",
          "name": "glucan endo-1,2-beta-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008422"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0033919",
          "name": "glucan 1,3-alpha-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0090600"
              ]
            }
          }
        },
        {
          "id": "GO:0033933",
          "name": "branched-dextran exo-1,2-alpha-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0034321",
          "name": "alcohol O-octanoyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016413",
                "GO:0016415",
                "GO:0034318"
              ],
              "previous": [
                "GO:0016413",
                "GO:0016414",
                "GO:0034318"
              ]
            }
          }
        },
        {
          "id": "GO:0035299",
          "name": "inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120517"
              ],
              "previous": [
                "GO:0016773",
                "GO:0180030"
              ]
            }
          }
        },
        {
          "id": "GO:0036239",
          "name": "taxoid 7beta-hydroxylase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016712"
              ],
              "previous": [
                "GO:0016709"
              ]
            }
          }
        },
        {
          "id": "GO:0042281",
          "name": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004583"
              ],
              "previous": [
                "GO:0046527"
              ]
            }
          }
        },
        {
          "id": "GO:0042283",
          "name": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004583"
              ],
              "previous": [
                "GO:0046527"
              ]
            }
          }
        },
        {
          "id": "GO:0042973",
          "name": "glucan endo-1,3-beta-D-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008422"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0043794",
          "name": "formate dehydrogenase (coenzyme F420) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016725"
              ],
              "previous": [
                "GO:0016903"
              ]
            }
          }
        },
        {
          "id": "GO:0043896",
          "name": "glucan 1,6-alpha-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0046557",
          "name": "glucan endo-1,6-beta-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008422"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0047241",
          "name": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0000026",
                "GO:0008194"
              ],
              "previous": [
                "GO:0008194",
                "GO:0016758"
              ]
            }
          }
        },
        {
          "id": "GO:0047312",
          "name": "L-phenylalanine-pyruvate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008793"
              ],
              "previous": [
                "GO:0070546"
              ]
            }
          }
        },
        {
          "id": "GO:0047315",
          "name": "kynurenine-glyoxylate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008483"
              ],
              "previous": [
                "GO:0036137"
              ]
            }
          }
        },
        {
          "id": "GO:0047372",
          "name": "monoacylglycerol lipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016298"
              ],
              "previous": [
                "GO:0016298",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0047714",
          "name": "galactolipase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016298"
              ],
              "previous": [
                "GO:0016298",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0050419",
          "name": "hydroxymandelonitrile lyase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016832"
              ],
              "previous": [
                "GO:0047606"
              ]
            }
          }
        },
        {
          "id": "GO:0050697",
          "name": "trichloroethene reductive dehalogenase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046992"
              ],
              "previous": [
                "GO:0016491"
              ]
            }
          }
        },
        {
          "id": "GO:0051118",
          "name": "glucan endo-1,3-alpha-glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0015926"
              ]
            }
          }
        },
        {
          "id": "GO:0051269",
          "name": "alpha-ketoester reductase (NADPH) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016620"
              ],
              "previous": [
                "GO:0016903"
              ]
            }
          }
        },
        {
          "id": "GO:0052595",
          "name": "aliphatic amine oxidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016641",
                "GO:0030058"
              ],
              "previous": [
                "GO:0016641"
              ]
            }
          }
        },
        {
          "id": "GO:0052739",
          "name": "phosphatidylserine 1-acylhydrolase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0004620",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0052740",
          "name": "1-acyl-2-lysophosphatidylserine acylhydrolase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0004620",
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0052919",
          "name": "aliphatic (R)-hydroxynitrile lyase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016832"
              ],
              "previous": [
                "GO:0047606"
              ]
            }
          }
        },
        {
          "id": "GO:0072374",
          "name": "carotene epsilon hydroxylase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016712"
              ],
              "previous": [
                "GO:0004497",
                "GO:0016705"
              ]
            }
          }
        },
        {
          "id": "GO:0080098",
          "name": "L-tyrosine-pyruvate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008793"
              ],
              "previous": [
                "GO:0070547"
              ]
            }
          }
        },
        {
          "id": "GO:0080130",
          "name": "L-phenylalanine-2-oxoglutarate transaminase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008793"
              ],
              "previous": [
                "GO:0008793",
                "GO:0070546"
              ]
            }
          }
        },
        {
          "id": "GO:0080132",
          "name": "fatty acid 2-hydroxylase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016716"
              ],
              "previous": [
                "GO:0016491"
              ]
            }
          }
        },
        {
          "id": "GO:0090409",
          "name": "malonyl-CoA synthetase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016405"
              ],
              "previous": [
                "GO:0015645",
                "GO:0016405"
              ]
            }
          }
        },
        {
          "id": "GO:0102244",
          "name": "3-aminopropanal dehydrogenase (NAD+) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004029"
              ],
              "previous": [
                "GO:0016620"
              ]
            }
          }
        },
        {
          "id": "GO:0102365",
          "name": "taxoid 2alpha-hydroxylase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016712"
              ],
              "previous": [
                "GO:0016709"
              ]
            }
          }
        },
        {
          "id": "GO:0102545",
          "name": "phosphatidyl phospholipase B activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0004620"
              ],
              "previous": [
                "GO:0052689"
              ]
            }
          }
        },
        {
          "id": "GO:0102704",
          "name": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0033164"
              ],
              "previous": [
                "GO:0016758"
              ]
            }
          }
        },
        {
          "id": "GO:0102731",
          "name": "inositol-1,3,4,6-tetrakisphosphate 2-kinase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0051765"
              ],
              "previous": [
                "GO:0016773"
              ]
            }
          }
        },
        {
          "id": "GO:0102732",
          "name": "inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0120517"
              ],
              "previous": [
                "GO:0016773"
              ]
            }
          }
        },
        {
          "id": "GO:0102734",
          "name": "brassinolide synthase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0016712"
              ],
              "previous": [
                "GO:0016709"
              ]
            }
          }
        },
        {
          "id": "GO:0102771",
          "name": "dihydroceramide fatty acyl 2-hydroxylase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0080132"
              ],
              "previous": [
                "GO:0016716"
              ]
            }
          }
        },
        {
          "id": "GO:0103045",
          "name": "methione N-acyltransferase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008080"
              ],
              "previous": [
                "GO:0016747"
              ]
            }
          }
        },
        {
          "id": "GO:0106407",
          "name": "Glc2Man9GlcNAc2 oligosaccharide glucosidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0090599"
              ],
              "previous": [
                "GO:0004573"
              ]
            }
          }
        },
        {
          "id": "GO:0160182",
          "name": "nitrate reductase (quinone) activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0008940"
              ],
              "previous": [
                "GO:0008940",
                "GO:0052586"
              ]
            }
          }
        },
        {
          "id": "GO:1990534",
          "name": "thermospermine oxidase activity",
          "changes": {
            "is_a": {
              "current": [
                "GO:0046592"
              ],
              "previous": [
                "GO:0016647"
              ]
            }
          }
        }
      ]
    }
  }
}