goslim generic.owl
type: Ontology
version IRI: goslim generic.owl
version info: 2024-06-14

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

nuclear chromosome
type: Class
equivalent class: Class
  intersection of: chromosome
  intersection of: Restriction
    on property: part of
    some values from: nucleus
subclass of: chromosome
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
has_narrow_synonym: nuclear interphase chromosome
has_obo_namespace: cellular_component
id: GO:0000228
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: nuclear chromosome
annotated property: definition
annotated target: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah

mitotic cell cycle
type: Class
subclass of: Restriction
  on property: has part
  some values from: mitotic nuclear division
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

cytokinesis
type: Class
subclass of: Restriction
  on property: has part
  some values from: membrane organization
definition: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Wikipedia:Cytokinesis
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
has_obo_namespace: biological_process
id: GO:0000910
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.

Axiom
annotated source: cytokinesis
annotated property: definition
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
database_cross_reference: GOC:mtg_cell_cycle

Axiom
annotated source: cytokinesis
annotated property: has_exact_synonym
annotated target: cytokinesis involved in cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

virus receptor activity
type: Class
definition: Combining with a virus component and mediating entry of the virus into the cell.
has_exact_synonym: viral receptor activity
has_obo_namespace: molecular_function
id: GO:0001618
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: virus receptor activity
annotated property: definition
annotated target: Combining with a virus component and mediating entry of the virus into the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:dph
database_cross_reference: PMID:7621403
database_cross_reference: UniProtKB-KW:KW-1183

cytoplasmic translation
type: Class
definition: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
created by: hjd
creation date: 2011-06-09T03:11:53Z
has_obo_namespace: biological_process
id: GO:0002181
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.

Axiom
annotated source: cytoplasmic translation
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
database_cross_reference: GOC:hjd

immune system process
type: Class
definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
RO_0002161: NCBITaxon 4895
database_cross_reference: Wikipedia:Immune_system
has_obo_namespace: biological_process
id: GO:0002376
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).

Axiom
annotated source: immune system process
annotated property: definition
annotated target: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

muscle system process
type: Class
definition: A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
has_obo_namespace: biological_process
has_related_synonym: muscle physiological process
id: GO:0003012
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: muscle system process
annotated property: definition
annotated target: A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
database_cross_reference: GOC:mtg_cardio

circulatory system process
type: Class
definition: A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
database_cross_reference: Wikipedia:Circulatory_system
has_obo_namespace: biological_process
id: GO:0003013
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: circulatory system process
annotated property: definition
annotated target: A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
database_cross_reference: GOC:mtg_cardio

renal system process
type: Class
definition: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
has_exact_synonym: excretory system process
has_obo_namespace: biological_process
has_related_synonym: kidney system process
id: GO:0003014
in_subset: goslim generic

Axiom
annotated source: renal system process
annotated property: definition
annotated target: A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
database_cross_reference: GOC:cjm
database_cross_reference: GOC:mtg_cardio
database_cross_reference: GOC:mtg_kidney_jan10

respiratory system process
type: Class
definition: A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
has_alternative_id: GO:0010802
has_exact_synonym: respiratory gaseous exchange
has_obo_namespace: biological_process
id: GO:0003016
in_subset: goslim generic

Axiom
annotated source: respiratory system process
annotated property: definition
annotated target: A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mtg_cardio
database_cross_reference: GOC:tb

DNA binding
type: Class
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

RNA binding
type: Class
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

cytoskeletal motor activity
type: Class
definition: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
term tracker item: https://github.com/geneontology/go-ontology/issues/19590
term tracker item: https://github.com/geneontology/go-ontology/issues/21756
has_broad_synonym: motor activity
database_cross_reference: Reactome:R-HSA-1861595
has_obo_namespace: molecular_function
id: GO:0003774
in_subset: goslim candida
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: cytoskeletal motor activity
annotated property: definition
annotated target: Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:11242086
database_cross_reference: PMID:29716949

Extension of pseudopodia by myosin-X in a PI3K dependent manner
type: Axiom
annotated source: cytoskeletal motor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1861595

catalytic activity
type: Class
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
id: GO:0003824
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon

Axiom
annotated source: catalytic activity
annotated property: definition
annotated target: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198506732

Axiom
annotated source: catalytic activity
annotated property: has_exact_synonym
annotated target: enzyme activity
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

GTPase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
term tracker item: https://github.com/geneontology/go-ontology/issues/26014
created by: dph
creation date: 2015-11-11T12:47:56Z
has_alternative_id: GO:0061745
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
database_cross_reference: MetaCyc:RXN0-5462
database_cross_reference: RHEA:19669
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9018814
database_cross_reference: Reactome:R-HSA-9018826
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
has_narrow_synonym: ARF small monomeric GTPase activity
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation
has_narrow_synonym: protein-synthesizing GTPase activity, initiation
has_narrow_synonym: protein-synthesizing GTPase activity, termination
has_narrow_synonym: signal-recognition-particle GTPase activity

Axiom
annotated source: GTPase activity
annotated property: definition
annotated target: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
database_cross_reference: PMID:26832457
database_cross_reference: PMID:27218782

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983422

structural molecule activity
type: Class
definition: The action of a molecule that contributes to the structural integrity of a complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/24130
has_obo_namespace: molecular_function
id: GO:0005198
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: structural molecule activity
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a complex.
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

transporter activity
type: Class
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
term tracker item: https://github.com/geneontology/go-ontology/issues/27621
has_alternative_id: GO:0005478
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

extracellular region
type: Class
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:go_curators

extracellular space
type: Class
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: NIF_Subcellular:sao1425028079
has_obo_namespace: cellular_component
has_related_synonym: intercellular space
id: GO:0005615
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

Axiom
annotated source: extracellular space
annotated property: definition
annotated target: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: ISBN:0198547684

cell wall
type: Class
subclass of: external encapsulating structure
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/21669
RO_0002161: NCBITaxon_33208
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

nucleus
type: Class
subclass of: organelle
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:go_curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

nuclear envelope
type: Class
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
has_alternative_id: GO:0005636
database_cross_reference: Wikipedia:Nuclear_envelope
has_obo_namespace: cellular_component
id: GO:0005635
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: nuclear envelope
annotated property: definition
annotated target: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
database_cross_reference: ISBN:0198547684

nucleoplasm
type: Class
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: That part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: NIF_Subcellular:sao661522542
database_cross_reference: Wikipedia:Nucleoplasm
has_obo_namespace: cellular_component
id: GO:0005654
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: nucleoplasm
annotated property: definition
annotated target: That part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: GOC:ma
database_cross_reference: ISBN:0124325653

chromosome
type: Class
subclass of: organelle
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: Wikipedia:Chromosome
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
id: GO:0005694
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684

nucleolus
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
id: GO:0005730
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleolus
annotated property: definition
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732

mitochondrion
type: Class
subclass of: organelle
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

lysosome
type: Class
subclass of: vacuole
definition: A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
RO_0002161: NCBITaxon 4751
database_cross_reference: NIF_Subcellular:sao585356902
database_cross_reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
id: GO:0005764
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: lysosome
annotated property: definition
annotated target: A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

endosome
type: Class
subclass of: cytoplasmic vesicle
definition: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: NIF_Subcellular:sao1720343330
database_cross_reference: Wikipedia:Endosome
has_obo_namespace: cellular_component
id: GO:0005768
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: endosome
annotated property: definition
annotated target: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:19696797

vacuole
type: Class
subclass of: organelle
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

peroxisome
type: Class
subclass of: organelle
definition: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
has_alternative_id: GO:0019818
has_broad_synonym: peroxisome vesicle
database_cross_reference: NIF_Subcellular:sao499555322
database_cross_reference: Wikipedia:Peroxisome
has_obo_namespace: cellular_component
has_related_synonym: peroxisomal
id: GO:0005777
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: peroxisome
annotated property: definition
annotated target: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
database_cross_reference: GOC:pm
database_cross_reference: PMID:9302272
database_cross_reference: UniProtKB-KW:KW-0576

endoplasmic reticulum
type: Class
subclass of: organelle
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
subclass of: organelle
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
database_cross_reference: ISBN:0198506732

lipid droplet
type: Class
subclass of: organelle
definition: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
has_exact_synonym: adiposome
has_exact_synonym: lipid body
has_exact_synonym: lipid particle
has_obo_namespace: cellular_component
id: GO:0005811
in_subset: goslim chembl
in_subset: goslim generic
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.

Axiom
annotated source: lipid droplet
annotated property: definition
annotated target: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

microtubule organizing center
type: Class
subclass of: Restriction
  on property: part of
  some values from: cytoskeleton
definition: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: Wikipedia:Microtubule_organizing_center
has_exact_synonym: MTOC
has_exact_synonym: microtubule organising centre
has_obo_namespace: cellular_component
id: GO:0005815
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: microtubule organizing center
annotated property: definition
annotated target: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:17072892
database_cross_reference: PMID:17245416
database_cross_reference: Wikipedia:Microtubule_organizing_center

cytosol
type: Class
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
id: GO:0005829
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cytosol
annotated property: definition
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:jl

ribosome
type: Class
subclass of: organelle
definition: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
has_alternative_id: GO:0033279
database_cross_reference: NIF_Subcellular:sao1429207766
database_cross_reference: Wikipedia:Ribosome
has_narrow_synonym: free ribosome
has_narrow_synonym: membrane bound ribosome
has_obo_namespace: cellular_component
has_related_synonym: ribosomal RNA
id: GO:0005840
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: ribosome
annotated property: definition
annotated target: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: free ribosome
database_cross_reference: NIF_Subcellular:sao1139385046

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: membrane bound ribosome
database_cross_reference: NIF_Subcellular:sao1291545653

cytoskeleton
type: Class
subclass of: organelle
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

cilium
type: Class
subclass of: organelle
definition: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
RO_0002161: NCBITaxon 3176
RO_0002161: NCBITaxon 3312
RO_0002161: NCBITaxon 3378
RO_0002161: NCBITaxon 3398
RO_0002161: NCBITaxon 4890
RO_0002161: NCBITaxon 5782
has_alternative_id: GO:0072372
database_cross_reference: FMA:67181
database_cross_reference: NIF_Subcellular:sao787716553
database_cross_reference: Wikipedia:Cilium
has_exact_synonym: eukaryotic flagellum
has_exact_synonym: microtubule-based flagellum
has_narrow_synonym: primary cilium
has_obo_namespace: cellular_component
has_related_synonym: flagellum
id: GO:0005929
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.

Axiom
annotated source: cilium
annotated property: definition
annotated target: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:curators
database_cross_reference: GOC:kmv
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16824949
database_cross_reference: PMID:17009929
database_cross_reference: PMID:20144998

carbohydrate metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
term tracker item: https://github.com/geneontology/go-ontology/issues/22880
created by: jl
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

generation of precursor metabolites and energy
type: Class
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
has_broad_synonym: energy pathways
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
has_related_synonym: metabolic energy generation
id: GO:0006091
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
database_cross_reference: GOC:jl

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

DNA replication
type: Class
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/10596
has_alternative_id: GO:0055133
database_cross_reference: Wikipedia:DNA_replication
has_obo_namespace: biological_process
id: GO:0006260
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.

Axiom
annotated source: DNA replication
annotated property: definition
annotated target: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
database_cross_reference: GOC:mah

DNA repair
type: Class
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
id: GO:0006281
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA repair
annotated property: definition
annotated target: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: PMID:11563486

DNA recombination
type: Class
definition: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
has_obo_namespace: biological_process
id: GO:0006310
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA recombination
annotated property: definition
annotated target: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
database_cross_reference: ISBN:0198506732

chromatin organization
type: Class
definition: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/22130
term tracker item: https://github.com/geneontology/go-ontology/issues/23549
has_alternative_id: GO:0006333
has_alternative_id: GO:0006336
has_alternative_id: GO:0016568
has_alternative_id: GO:0031497
has_alternative_id: GO:0034724
has_broad_synonym: chromatin maintenance
has_exact_synonym: chromatin organisation
has_exact_synonym: establishment of chromatin architecture
has_exact_synonym: establishment or maintenance of chromatin architecture
has_narrow_synonym: DNA replication-independent chromatin assembly
has_narrow_synonym: DNA replication-independent chromatin organization
has_narrow_synonym: DNA replication-independent nucleosome organisation
has_narrow_synonym: DNA replication-independent nuclesome assembly
has_narrow_synonym: chromatin assembly
has_narrow_synonym: transcription-coupled nucleosome assembly
has_obo_namespace: biological_process
has_related_synonym: chromatin assembly or disassembly
has_related_synonym: chromatin assembly/disassembly
has_related_synonym: chromatin modification
id: GO:0006325
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: chromatin organization
annotated property: definition
annotated target: The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
database_cross_reference: PMID:20404130

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: chromatin organisation
database_cross_reference: GOC:mah

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: establishment of chromatin architecture
database_cross_reference: GOC:mah

Axiom
annotated source: chromatin organization
annotated property: has_exact_synonym
annotated target: establishment or maintenance of chromatin architecture
database_cross_reference: GOC:mah

DNA-templated transcription
type: Class
definition: The synthesis of an RNA transcript from a DNA template.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
term tracker item: https://github.com/geneontology/go-ontology/issues/16737
term tracker item: https://github.com/geneontology/go-ontology/issues/22258
term tracker item: https://github.com/geneontology/go-ontology/issues/22555
has_alternative_id: GO:0001121
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database_cross_reference: Wikipedia:Transcription_(genetics)
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: transcription, DNA-dependent
has_exact_synonym: transcription, DNA-templated
has_narrow_synonym: bacterial transcription
has_narrow_synonym: transcription from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
id: GO:0006351
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: DNA-templated transcription
annotated property: definition
annotated target: The synthesis of an RNA transcript from a DNA template.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Axiom
annotated source: DNA-templated transcription
annotated property: has_exact_synonym
annotated target: transcription, DNA-dependent
database_cross_reference: GOC:txnOH

regulation of DNA-templated transcription
type: Class
subclass of: Restriction
  on property: regulates
  some values from: DNA-templated transcription
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/25256
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_broad_synonym: transcriptional control
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-templated
has_obo_namespace: biological_process
has_related_synonym: regulation of gene-specific transcription
id: GO:0006355
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: has_exact_synonym
annotated target: regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

tRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
has_exact_synonym: tRNA metabolism
has_obo_namespace: biological_process
id: GO:0006399
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: tRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
database_cross_reference: ISBN:0198506732

protein folding
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein maturation
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
term tracker item: https://github.com/geneontology/go-ontology/issues/25673
has_alternative_id: GO:0007022
has_alternative_id: GO:0007024
has_alternative_id: GO:0007025
database_cross_reference: Wikipedia:Protein_folding
has_narrow_synonym: alpha-tubulin folding
has_narrow_synonym: beta-tubulin folding
has_narrow_synonym: chaperonin-mediated tubulin folding
has_obo_namespace: biological_process
has_related_synonym: chaperone activity
has_related_synonym: chaperonin ATPase activity
has_related_synonym: co-chaperone activity
has_related_synonym: co-chaperonin activity
has_related_synonym: glycoprotein-specific chaperone activity
has_related_synonym: non-chaperonin molecular chaperone ATPase activity
has_related_synonym: protein complex assembly, multichaperone pathway
id: GO:0006457
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: protein folding
annotated property: definition
annotated target: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:rb

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: alpha-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: beta-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: chaperonin-mediated tubulin folding
database_cross_reference: GOC:mah

protein glycosylation
type: Class
subclass of: Restriction
  on property: part of
  some values from: carbohydrate derivative metabolic process
definition: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
has_alternative_id: GO:0065006
has_exact_synonym: protein amino acid glycosylation
has_obo_namespace: biological_process
has_related_synonym: protein-carbohydrate complex assembly
id: GO:0006486
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein glycosylation
annotated property: definition
annotated target: A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pr

Axiom
annotated source: protein glycosylation
annotated property: has_exact_synonym
annotated target: protein amino acid glycosylation
database_cross_reference: GOC:bf

amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
term tracker item: https://github.com/geneontology/go-ontology/issues/17904
has_alternative_id: GO:0006519
has_exact_synonym: cellular amino acid metabolic process
has_exact_synonym: cellular amino acid metabolism
has_obo_namespace: biological_process
has_related_synonym: amino acid and derivative metabolism
has_related_synonym: cellular amino acid and derivative metabolic process
id: GO:0006520
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
database_cross_reference: ISBN:0198506732

cellular modified amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
has_exact_synonym: amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolism
has_exact_synonym: cellular modified amino acid metabolism
has_exact_synonym: modified amino acid metabolic process
has_exact_synonym: modified amino acid metabolism
has_obo_namespace: biological_process
id: GO:0006575
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
database_cross_reference: GOC:ai

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolic process
database_cross_reference: GOC:mah

Axiom
annotated source: cellular modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolism
database_cross_reference: GOC:mah

lipid metabolic process
type: Class
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

vitamin metabolic process
type: Class
definition: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
has_exact_synonym: vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006766
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: GOC:ai

sulfur compound metabolic process
type: Class
definition: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: Wikipedia:Sulfur_metabolism
has_exact_synonym: sulfur metabolism
has_exact_synonym: sulphur metabolic process
has_exact_synonym: sulphur metabolism
has_obo_namespace: biological_process
id: GO:0006790
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: sulfur compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: GOC:ai

intracellular protein transport
type: Class
definition: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
has_alternative_id: GO:0032779
has_obo_namespace: biological_process
has_related_synonym: copper-induced intracellular protein transport
id: GO:0006886
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: intracellular protein transport
annotated property: definition
annotated target: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein transport
annotated property: has_related_synonym
annotated target: copper-induced intracellular protein transport
database_cross_reference: GOC:al

nucleocytoplasmic transport
type: Class
definition: The directed movement of molecules between the nucleus and the cytoplasm.
has_alternative_id: GO:0000063
has_narrow_synonym: nucleocytoplasmic shuttling
has_obo_namespace: biological_process
id: GO:0006913
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.

Axiom
annotated source: nucleocytoplasmic transport
annotated property: definition
annotated target: The directed movement of molecules between the nucleus and the cytoplasm.
database_cross_reference: GOC:go_curators

autophagy
type: Class
definition: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
term tracker item: https://github.com/geneontology/go-ontology/issues/25541
has_alternative_id: GO:0016238
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
id: GO:0006914
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: autophagy
annotated property: definition
annotated target: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
database_cross_reference: GOC:autophagy
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:11099404
database_cross_reference: PMID:29455577
database_cross_reference: PMID:9412464

inflammatory response
type: Class
definition: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
has_broad_synonym: inflammation
database_cross_reference: Wikipedia:Inflammation
has_obo_namespace: biological_process
id: GO:0006954
in_subset: goslim generic

Axiom
annotated source: inflammatory response
annotated property: definition
annotated target: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0198506732

mitochondrion organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
has_exact_synonym: mitochondria organization
has_exact_synonym: mitochondrial biogenesis
has_exact_synonym: mitochondrial organization
has_exact_synonym: mitochondrion biogenesis
has_exact_synonym: mitochondrion organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrion morphogenesis
has_related_synonym: mitochondrion organization and biogenesis
id: GO:0007005
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: mitochondrion organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:sgd_curators
database_cross_reference: PMID:9786946

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondria organization
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondrion organisation
database_cross_reference: GOC:mah

cytoskeleton organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

microtubule-based movement
type: Class
definition: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
has_obo_namespace: biological_process
id: GO:0007018
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: microtubule-based movement
annotated property: definition
annotated target: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
database_cross_reference: GOC:cjm
database_cross_reference: ISBN:0815316194

peroxisome organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
has_exact_synonym: peroxisome organisation
has_obo_namespace: biological_process
has_related_synonym: peroxisome organization and biogenesis
id: GO:0007031
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: peroxisome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
database_cross_reference: GOC:mah

Axiom
annotated source: peroxisome organization
annotated property: has_related_synonym
annotated target: peroxisome organization and biogenesis
database_cross_reference: GOC:mah

lysosome organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
RO_0002161: NCBITaxon 4751
has_exact_synonym: lysosome organisation
has_obo_namespace: biological_process
has_related_synonym: lysosome organization and biogenesis
id: GO:0007040
in_subset: goslim generic

Axiom
annotated source: lysosome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
database_cross_reference: GOC:mah

Axiom
annotated source: lysosome organization
annotated property: has_related_synonym
annotated target: lysosome organization and biogenesis
database_cross_reference: GOC:mah

chromosome segregation
type: Class
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

cell adhesion
type: Class
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
created by: dos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion
annotated property: definition
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf

establishment or maintenance of cell polarity
type: Class
definition: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
has_alternative_id: GO:0030012
has_alternative_id: GO:0030467
has_obo_namespace: biological_process
has_related_synonym: cell polarity
has_related_synonym: establishment and/or maintenance of cell polarity
has_related_synonym: establishment and/or maintenance of cell polarization
id: GO:0007163
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: definition
annotated target: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
database_cross_reference: GOC:mah

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: has_related_synonym
annotated target: cell polarity
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

cytoskeletal protein binding
type: Class
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

lipid binding
type: Class
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

plastid
type: Class
subclass of: organelle
definition: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
RO_0002161: NCBITaxon 2
RO_0002161: NCBITaxon 2157
RO_0002161: NCBITaxon_28009
RO_0002161: NCBITaxon_33208
RO_0002161: NCBITaxon 4751
RO_0002161: NCBITaxon_554915
database_cross_reference: Wikipedia:Plastid
has_obo_namespace: cellular_component
id: GO:0009536
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: plastid
annotated property: definition
annotated target: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198547684

thylakoid
type: Class
subclass of: organelle
definition: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
term tracker item: https://github.com/geneontology/go-ontology/issues/13958
RO_0002161: NCBITaxon_33208
database_cross_reference: Wikipedia:Thylakoid
has_obo_namespace: cellular_component
has_related_synonym: photosynthetic membrane
id: GO:0009579
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.

Axiom
annotated source: thylakoid
annotated property: definition
annotated target: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
database_cross_reference: GOC:ds
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

cyclase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of a ring closure reaction.
has_obo_namespace: molecular_function
id: GO:0009975
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: cyclase activity
annotated property: definition
annotated target: Catalysis of a ring closure reaction.
database_cross_reference: ISBN:0198547684

programmed cell death
type: Class
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24835
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

photosynthesis
type: Class
definition: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
RO_0002161: NCBITaxon_33208
RO_0002161: NCBITaxon 4895
database_cross_reference: Wikipedia:Photosynthesis
has_obo_namespace: biological_process
id: GO:0015979
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: photosynthesis
annotated property: definition
annotated target: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
database_cross_reference: ISBN:0198547684

mRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
has_exact_synonym: mRNA metabolism
has_obo_namespace: biological_process
id: GO:0016071
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: mRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
database_cross_reference: ISBN:0198506732

snRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
has_exact_synonym: snRNA metabolism
has_obo_namespace: biological_process
id: GO:0016073
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: snRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
database_cross_reference: ISBN:0198506732

vesicle-mediated transport
type: Class
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/25421
has_alternative_id: GO:0006899
has_exact_synonym: vesicle transport
has_exact_synonym: vesicular transport
has_narrow_synonym: nonselective vesicle transport
has_obo_namespace: biological_process
has_related_synonym: protein sorting along secretory pathway
has_related_synonym: vesicle trafficking
id: GO:0016192
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: vesicle-mediated transport
annotated property: definition
annotated target: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: ISBN:08789310662000

Axiom
annotated source: vesicle-mediated transport
annotated property: has_exact_synonym
annotated target: vesicular transport
database_cross_reference: GOC:mah

antioxidant activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: detoxification
definition: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
has_obo_namespace: molecular_function
id: GO:0016209
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: antioxidant activity
annotated property: definition
annotated target: Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
database_cross_reference: ISBN:0198506732

oxidoreductase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-209921
database_cross_reference: Reactome:R-HSA-209960
database_cross_reference: Reactome:R-HSA-3095889
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-5662660
database_cross_reference: Reactome:R-HSA-8878581
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: GOC:go_curators

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

Monoiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209921

Diiodinated tyrosine can be deiodinated
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-209960

MMACHC dealkylates RCbl
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3095889

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

Dopachrome is transformed to DHICA by DCT
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5662660

TYRP1 oxidises DHICA to IQCA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8878581

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

transferase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: ISBN:0198506732

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

hydrolase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

lyase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-
database_cross_reference: Reactome:R-HSA-5696408
database_cross_reference: Reactome:R-HSA-6782895
has_obo_namespace: molecular_function
id: GO:0016829
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lyase activity
annotated property: definition
annotated target: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: ISBN:0198547684

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5696408

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782895

isomerase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: EC:5.-.-.-
database_cross_reference: Reactome:R-HSA-6787623
has_narrow_synonym: other isomerase activity
has_obo_namespace: molecular_function
id: GO:0016853
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: isomerase activity
annotated property: definition
annotated target: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: ISBN:0198506732

TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787623

ligase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: GOC:mah

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

reproductive process
type: Class
definition: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
created by: jl
creation date: 2012-09-19T15:56:06Z
has_alternative_id: GO:0044702
database_cross_reference: Wikipedia:Reproduction
has_obo_namespace: biological_process
has_related_synonym: single organism reproductive process
id: GO:0022414
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete

digestive system process
type: Class
definition: A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
has_obo_namespace: biological_process
id: GO:0022600
in_subset: goslim generic

Axiom
annotated source: digestive system process
annotated property: definition
annotated target: A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:jid
database_cross_reference: GOC:mtg_cardio

signaling
type: Class
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
created by: jl
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has_exact_synonym: biological signaling
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in_subset: goslim agr
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

Axiom
annotated source: signaling
annotated property: definition
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling
annotated property: has_related_synonym
annotated target: signalling process
database_cross_reference: GOC:mah

cell differentiation
type: Class
definition: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
term tracker item: https://github.com/geneontology/go-ontology/issues/24390
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
id: GO:0030154
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

protein catabolic process
type: Class
definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0044254
has_alternative_id: GO:0044257
database_cross_reference: Wikipedia:Protein_catabolism
has_exact_synonym: cellular protein breakdown
has_exact_synonym: cellular protein catabolic process
has_exact_synonym: cellular protein catabolism
has_exact_synonym: cellular protein degradation
has_exact_synonym: protein breakdown
has_exact_synonym: protein catabolism
has_exact_synonym: protein degradation
has_narrow_synonym: multicellular organismal protein catabolic process
has_obo_namespace: biological_process
has_related_synonym: pheromone catabolic process
has_related_synonym: pheromone catabolism
id: GO:0030163
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.

Axiom
annotated source: protein catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
database_cross_reference: GOC:mah

extracellular matrix organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
has_exact_synonym: extracellular matrix organisation
has_obo_namespace: biological_process
has_related_synonym: extracellular matrix organization and biogenesis
id: GO:0030198
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: extracellular matrix organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: GOC:mah

Axiom
annotated source: extracellular matrix organization
annotated property: has_related_synonym
annotated target: extracellular matrix organization and biogenesis
database_cross_reference: GOC:mah

external encapsulating structure
type: Class
definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
has_obo_namespace: cellular_component
id: GO:0030312
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.

Axiom
annotated source: external encapsulating structure
annotated property: definition
annotated target: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
database_cross_reference: GOC:go_curators

extracellular matrix
type: Class
subclass of: external encapsulating structure
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
has_alternative_id: GO:0005578
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: Wikipedia:Extracellular_matrix
has_exact_synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: extracellular matrix
annotated property: definition
annotated target: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rph
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: PMID:21123617
database_cross_reference: PMID:28089324

regulatory ncRNA-mediated gene silencing
type: Class
definition: A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
term tracker item: https://github.com/geneontology/go-ontology/issues/22202
term tracker item: https://github.com/geneontology/go-ontology/issues/22635
has_exact_synonym: RNA-dependent gene silencing
has_obo_namespace: biological_process
has_related_synonym: RNA-mediated gene silencing
has_related_synonym: gene silencing by RNA
id: GO:0031047
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: regulatory ncRNA-mediated gene silencing
annotated property: definition
annotated target: A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
database_cross_reference: PMID:15020054

protein tag activity
type: Class
definition: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
has_broad_synonym: covalent modifier
has_exact_synonym: protein tag
has_exact_synonym: ubiquitin-like protein modifier
has_obo_namespace: molecular_function
has_related_synonym: protein tagging activity
has_related_synonym: ubiquitin
id: GO:0031386
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.

Axiom
annotated source: protein tag activity
annotated property: definition
annotated target: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19028679
database_cross_reference: PMID:20054389
database_cross_reference: PMID:6305978

Axiom
annotated source: protein tag activity
annotated property: has_broad_synonym
annotated target: covalent modifier
database_cross_reference: GOC:vw

cytoplasmic vesicle
type: Class
subclass of: organelle
definition: A vesicle found in the cytoplasm of a cell.
has_alternative_id: GO:0016023
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic membrane bounded vesicle
has_related_synonym: cytoplasmic membrane-enclosed vesicle
has_related_synonym: cytoplasmic, membrane-bounded vesicle
id: GO:0031410
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim yeast

Axiom
annotated source: cytoplasmic vesicle
annotated property: definition
annotated target: A vesicle found in the cytoplasm of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicles

telomere organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.
has_exact_synonym: chromosome organization, telomeric
has_exact_synonym: organization of chromosome, telomeric region
has_exact_synonym: telomere organisation
has_obo_namespace: biological_process
has_related_synonym: telomere organization and biogenesis
id: GO:0032200
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: telomere organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: telomere organization
annotated property: has_exact_synonym
annotated target: telomere organisation
database_cross_reference: GOC:mah

Axiom
annotated source: telomere organization
annotated property: has_related_synonym
annotated target: telomere organization and biogenesis
database_cross_reference: GOC:mah

cell junction organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.
has_exact_synonym: cell junction assembly and maintenance
has_exact_synonym: cell junction organisation
has_obo_namespace: biological_process
has_related_synonym: cell junction biogenesis
id: GO:0034330
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: cell junction organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cell junction organization
annotated property: has_exact_synonym
annotated target: cell junction organisation
database_cross_reference: GOC:mah

cargo receptor activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
subclass of: Restriction
  on property: has part
  some values from: molecular adaptor activity
definition: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
term tracker item: https://github.com/geneontology/go-ontology/issues/26872
created by: bf
creation date: 2011-08-01T02:50:45Z
has_broad_synonym: receptor activity
has_broad_synonym: transport receptor activity
database_cross_reference: Reactome:R-HSA-3000103
database_cross_reference: Reactome:R-HSA-3000112
database_cross_reference: Reactome:R-HSA-3000122
database_cross_reference: Reactome:R-HSA-3000137
database_cross_reference: Reactome:R-HSA-350168
database_cross_reference: Reactome:R-HSA-9759202
database_cross_reference: Reactome:R-HSA-9759209
has_narrow_synonym: endocytic receptor activity
has_narrow_synonym: receptor activity involved in receptor-mediated endocytosis
has_obo_namespace: molecular_function
id: GO:0038024
in_subset: goslim drosophila
in_subset: goslim generic
comment: Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'.

Axiom
annotated source: cargo receptor activity
annotated property: definition
annotated target: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
database_cross_reference: PMID:15239958
database_cross_reference: PMID:27903609

Axiom
annotated source: cargo receptor activity
annotated property: has_broad_synonym
annotated target: transport receptor activity
database_cross_reference: GOC:signaling

CUBN:AMN binds CBLIF:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000103

CD320-mediated TCN2:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000112

CD320 binds extracellular TCN2:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000122

CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000137

LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350168

LRP2-mediated TCN2:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759202

LRP2 binds extracellular TCN2:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759209

Axiom
annotated source: cargo receptor activity
annotated property: has_narrow_synonym
annotated target: endocytic receptor activity
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:0123645387
database_cross_reference: PMID:12671190

Axiom
annotated source: cargo receptor activity
annotated property: has_narrow_synonym
annotated target: receptor activity involved in receptor-mediated endocytosis
database_cross_reference: GOC:bf

wound healing
type: Class
subclass of: Restriction
  on property: has part
  some values from: anatomical structure development
definition: The series of events that restore integrity to a damaged tissue, following an injury.
database_cross_reference: Wikipedia:Wound_healing
has_obo_namespace: biological_process
id: GO:0042060
in_subset: goslim generic

Axiom
annotated source: wound healing
annotated property: definition
annotated target: The series of events that restore integrity to a damaged tissue, following an injury.
database_cross_reference: GOC:bf
database_cross_reference: PMID:15269788

ribosome biogenesis
type: Class
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
has_alternative_id: GO:0007046
has_exact_synonym: ribosome biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042254
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: ribosome biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:ma
database_cross_reference: PMID:26404467
database_cross_reference: Wikipedia:Ribosome_biogenesis

histone binding
type: Class
definition: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/23106
has_obo_namespace: molecular_function
has_related_synonym: histone-specific chaperone activity
id: GO:0042393
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: histone binding
annotated property: definition
annotated target: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16209651
database_cross_reference: PMID:30212449
database_cross_reference: PMID:9305837

organelle
type: Class
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao1539965131
database_cross_reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
id: GO:0043226
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

protein folding chaperone
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein folding
definition: Binding to a protein or a protein-containing complex to assist the protein folding process.
created by: jl
creation date: 2009-09-25T11:33:48Z
has_broad_synonym: chaperone activity
database_cross_reference: Reactome:R-HSA-9018785
has_exact_synonym: protein binding involved in protein folding
has_obo_namespace: molecular_function
id: GO:0044183
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: protein folding chaperone
annotated property: definition
annotated target: Binding to a protein or a protein-containing complex to assist the protein folding process.
database_cross_reference: GOC:mtg_cambridge_2009

RHOBTB2 binds GTP
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018785

cilium organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
created by: jl
creation date: 2013-03-27T15:09:58Z
has_exact_synonym: microtubule-based flagellum organization
has_obo_namespace: biological_process
id: GO:0044782
in_subset: goslim drosophila
in_subset: goslim generic
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: cilium organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl

translation regulator activity
type: Class
definition: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
has_exact_synonym: translation factor activity
has_obo_namespace: molecular_function
id: GO:0045182
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation regulator activity
annotated property: definition
annotated target: Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
database_cross_reference: GOC:ai

nutrient reservoir activity
type: Class
definition: Functions in the storage of nutritious substrates.
has_obo_namespace: molecular_function
has_related_synonym: storage protein
has_related_synonym: storage protein of fat body
has_related_synonym: yolk protein
id: GO:0045735
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.

Axiom
annotated source: nutrient reservoir activity
annotated property: definition
annotated target: Functions in the storage of nutritious substrates.
database_cross_reference: GOC:ai

receptor ligand activity
type: Class
subclass of: molecular function regulator activity
subclass of: Restriction
  on property: part of
  some values from: signaling
subclass of: Restriction
  on property: positively regulates
  some values from: molecular transducer activity
definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
term tracker item: https://github.com/geneontology/go-ontology/issues/14220
term tracker item: https://github.com/geneontology/go-ontology/issues/27076
created by: mah
creation date: 2010-09-13T04:51:59Z
has_alternative_id: GO:0071884
has_broad_synonym: receptor agonist activity
has_exact_synonym: signaling molecule
has_exact_synonym: signaling receptor ligand activity
has_obo_namespace: molecular_function
id: GO:0048018
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: receptor ligand activity
annotated property: definition
annotated target: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
database_cross_reference: GOC:kv
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

Axiom
annotated source: receptor ligand activity
annotated property: has_broad_synonym
annotated target: receptor agonist activity
database_cross_reference: GOC:molecular_function_refactoring

anatomical structure development
type: Class
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

cell motility
type: Class
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
RO_0002161: NCBITaxon 4890
has_exact_synonym: cell locomotion
has_exact_synonym: movement of a cell
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0048870
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell motility
annotated property: definition
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg

nervous system process
type: Class
definition: A organ system process carried out by any of the organs or tissues of neurological system.
term tracker item: https://github.com/geneontology/go-ontology/issues/13824
has_exact_synonym: neurological system process
has_exact_synonym: neurophysiological process
has_obo_namespace: biological_process
has_related_synonym: pan-neural process
id: GO:0050877
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: nervous system process
annotated property: definition
annotated target: A organ system process carried out by any of the organs or tissues of neurological system.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mtg_cardio

endocrine process
type: Class
definition: The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
has_exact_synonym: endocrine physiological process
has_exact_synonym: endocrine physiology
has_obo_namespace: biological_process
id: GO:0050886
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: endocrine process
annotated property: definition
annotated target: The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
database_cross_reference: ISBN:0721662544

protein maturation
type: Class
definition: Any process leading to the attainment of the full functional capacity of a protein.
has_obo_namespace: biological_process
id: GO:0051604
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein maturation
annotated property: definition
annotated target: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:ai

transmembrane transport
type: Class
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
created by: tb
creation date: 2015-10-21T13:22:47Z
has_alternative_id: GO:0090662
has_exact_synonym: membrane transport
has_narrow_synonym: ATP hydrolysis coupled transmembrane transport
has_obo_namespace: biological_process
id: GO:0055085
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: transmembrane transport
annotated property: definition
annotated target: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

nucleobase-containing small molecule metabolic process
type: Class
definition: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
has_exact_synonym: nucleobase, nucleoside and nucleotide metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
id: GO:0055086
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: GOC:vw

molecular transducer activity
type: Class
definition: A compound molecular function in which an effector function is controlled by one or more regulatory components.
has_obo_namespace: molecular_function
id: GO:0060089
in_subset: gocheck do not annotate
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: molecular transducer activity
annotated property: definition
annotated target: A compound molecular function in which an effector function is controlled by one or more regulatory components.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pdt

molecular adaptor activity
type: Class
definition: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
has_alternative_id: GO:0032947
has_exact_synonym: binding, bridging
has_obo_namespace: molecular_function
has_related_synonym: protein complex scaffold activity
has_related_synonym: protein-containing complex scaffold activity
id: GO:0060090
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular adaptor activity
annotated property: definition
annotated target: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
database_cross_reference: GOC:mtg_MIT_16mar07
database_cross_reference: GOC:vw

hepaticobiliary system process
type: Class
definition: An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.
created by: dph
creation date: 2010-01-22T09:09:10Z
has_exact_synonym: hepatobiliary system process
has_obo_namespace: biological_process
id: GO:0061007
in_subset: goslim generic

Axiom
annotated source: hepaticobiliary system process
annotated property: definition
annotated target: An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.
database_cross_reference: GOC:dph

Axiom
annotated source: hepaticobiliary system process
annotated property: has_exact_synonym
annotated target: hepatobiliary system process
database_cross_reference: GOC:dph

membrane organization
type: Class
definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
created by: jl
creation date: 2010-02-08T02:43:11Z
has_alternative_id: GO:0016044
has_alternative_id: GO:0044802
has_exact_synonym: cellular membrane organisation
has_exact_synonym: cellular membrane organization
has_exact_synonym: membrane organisation
has_obo_namespace: biological_process
has_related_synonym: membrane organization and biogenesis
has_related_synonym: single-organism membrane organization
id: GO:0061024
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: membrane organization
annotated property: definition
annotated target: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: membrane organization
annotated property: has_exact_synonym
annotated target: membrane organisation
database_cross_reference: GOC:mah

Axiom
annotated source: membrane organization
annotated property: has_related_synonym
annotated target: membrane organization and biogenesis
database_cross_reference: GOC:mah

protein-containing complex assembly
type: Class
definition: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/22580
has_alternative_id: GO:0006461
has_alternative_id: GO:0034622
has_alternative_id: GO:0043623
has_exact_synonym: cellular protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecule complex assembly
has_related_synonym: cellular protein-containing complex assembly
has_related_synonym: chaperone activity
has_related_synonym: macromolecular complex assembly
has_related_synonym: macromolecule complex assembly
has_related_synonym: protein complex assembly
has_related_synonym: protein complex formation
id: GO:0065003
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: protein-containing complex assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
database_cross_reference: GOC:jl

cell wall organization or biogenesis
type: Class
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
created by: mah
creation date: 2010-01-13T03:19:38Z
has_alternative_id: GO:0070882
has_exact_synonym: cell wall organisation or biogenesis
has_exact_synonym: cell wall organization or biogenesis at cellular level
has_exact_synonym: cellular cell wall organisation or biogenesis
has_exact_synonym: cellular cell wall organization or biogenesis
has_obo_namespace: biological_process
id: GO:0071554
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cell wall organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organization or biogenesis at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular cell wall organisation or biogenesis
database_cross_reference: GOC:mah

nitrogen cycle metabolic process
type: Class
definition: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
created by: mah
creation date: 2010-09-30T05:21:03Z
database_cross_reference: Wikipedia:Nitrogen_cycle
has_obo_namespace: biological_process
id: GO:0071941
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: nitrogen cycle metabolic process
annotated property: definition
annotated target: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16675690
database_cross_reference: Wikipedia:Nitrogen_cycle

protein localization to plasma membrane
type: Class
definition: A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
created by: tb
creation date: 2009-07-10T10:29:23Z
has_alternative_id: GO:0072661
has_alternative_id: GO:0090002
has_obo_namespace: biological_process
has_related_synonym: protein localisation in plasma membrane
has_related_synonym: protein localization in plasma membrane
has_related_synonym: protein targeting to plasma membrane
has_related_synonym: protein-plasma membrane targeting
id: GO:0072659
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: protein localization to plasma membrane
annotated property: definition
annotated target: A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to plasma membrane
annotated property: has_related_synonym
annotated target: protein localisation in plasma membrane
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to plasma membrane
annotated property: has_related_synonym
annotated target: protein-plasma membrane targeting
database_cross_reference: GOC:mah

toxin activity
type: Class
definition: Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
created by: tb
creation date: 2016-12-19T15:23:27Z
has_alternative_id: GO:0050827
database_cross_reference: Wikipedia:Toxin
has_exact_synonym: toxin receptor binding
has_obo_namespace: molecular_function
id: GO:0090729
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: toxin activity
annotated property: definition
annotated target: Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.
database_cross_reference: GOC:pt

defense response to other organism
type: Class
definition: Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/22173
created by: dos
creation date: 2013-11-11T12:59:11Z
has_alternative_id: GO:0009814
has_narrow_synonym: defence response incompatible interaction
has_narrow_synonym: defence response to pathogen, incompatible interaction
has_narrow_synonym: defense response, incompatible interaction
has_narrow_synonym: resistance response to pathogen
has_obo_namespace: biological_process
id: GO:0098542
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: defense response to other organism
annotated property: definition
annotated target: Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
database_cross_reference: GOC:dos

cell adhesion mediator activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: cell adhesion
definition: The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/22959
has_exact_synonym: cell adhesion molecule
has_exact_synonym: protein binding involved in cell adhesion
has_obo_namespace: molecular_function
id: GO:0098631
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion mediator activity
annotated property: definition
annotated target: The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell.
database_cross_reference: GOC:vw
database_cross_reference: Wikipedia:Cell_adhesion

detoxification
type: Class
definition: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
has_obo_namespace: biological_process
id: GO:0098754
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: detoxification
annotated property: definition
annotated target: Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
database_cross_reference: GOC:dos

molecular function regulator activity
type: Class
definition: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
term tracker item: https://github.com/geneontology/go-ontology/issues/20854
term tracker item: https://github.com/geneontology/go-ontology/issues/20862
term tracker item: https://github.com/geneontology/go-ontology/issues/25165
has_exact_synonym: molecular function regulator
has_obo_namespace: molecular_function
id: GO:0098772
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular function regulator activity
annotated property: definition
annotated target: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pt

virus coreceptor activity
type: Class
definition: Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
term tracker item: https://github.com/geneontology/go-ontology/issues/20137
created by: krc
creation date: 2020-10-20T18:32:45Z
has_exact_synonym: viral coreceptor activity
has_obo_namespace: molecular_function
id: GO:0120274
in_subset: goslim generic

Axiom
annotated source: virus coreceptor activity
annotated property: definition
annotated target: Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
database_cross_reference: GOC:ha
database_cross_reference: GOC:krc
database_cross_reference: PMID:16051304

meiotic nuclear division
type: Class
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: reproductive process
definition: One of the two nuclear divisions that occur as part of the meiotic cell cycle.
term tracker item: https://github.com/geneontology/go-ontology/issues/19910
created by: pg
creation date: 2017-03-23T09:40:00Z
has_exact_synonym: meiosis
has_obo_namespace: biological_process
id: GO:0140013
in_subset: goslim generic

Axiom
annotated source: meiotic nuclear division
annotated property: definition
annotated target: One of the two nuclear divisions that occur as part of the meiotic cell cycle.
database_cross_reference: PMID:9334324

mitotic nuclear division
type: Class
subclass of: Restriction
  on property: part of
  some values from: mitotic cell cycle
definition: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/19910
created by: pg
creation date: 2017-03-23T14:44:23Z
has_exact_synonym: mitosis
has_obo_namespace: biological_process
id: GO:0140014
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: mitotic nuclear division
annotated property: definition
annotated target: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
database_cross_reference: ISBN:0198547684

mitochondrial gene expression
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: mitochondrion
definition: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
created by: pg
creation date: 2017-06-26T10:57:45Z
has_obo_namespace: biological_process
id: GO:0140053
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: mitochondrial gene expression
annotated property: definition
annotated target: The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: PMID:27058308

catalytic activity, acting on a protein
type: Class
subclass of: catalytic activity
definition: Catalytic activity that acts to modify a protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
created by: pg
creation date: 2017-09-14T10:32:59Z
has_obo_namespace: molecular_function
id: GO:0140096
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on a protein
annotated property: definition
annotated target: Catalytic activity that acts to modify a protein.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

catalytic activity, acting on DNA
type: Class
subclass of: catalytic activity
definition: Catalytic activity that acts to modify DNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
created by: pg
creation date: 2017-09-14T12:03:51Z
has_obo_namespace: molecular_function
id: GO:0140097
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on DNA
annotated property: definition
annotated target: Catalytic activity that acts to modify DNA.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

catalytic activity, acting on RNA
type: Class
subclass of: catalytic activity
definition: Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.
term tracker item: https://github.com/geneontology/go-ontology/issues/14225
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
created by: pg
creation date: 2017-09-14T12:05:21Z
has_obo_namespace: molecular_function
id: GO:0140098
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: catalytic activity, acting on RNA
annotated property: definition
annotated target: Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

molecular carrier activity
type: Class
definition: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/14221
term tracker item: https://github.com/geneontology/go-ontology/issues/20848
created by: pg
creation date: 2017-09-19T13:10:18Z
has_obo_namespace: molecular_function
id: GO:0140104
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.

Axiom
annotated source: molecular carrier activity
annotated property: definition
annotated target: Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

transcription regulator activity
type: Class
definition: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/13588
term tracker item: https://github.com/geneontology/go-ontology/issues/23609
created by: pg
creation date: 2017-10-18T07:05:44Z
has_obo_namespace: molecular_function
id: GO:0140110
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: transcription regulator activity
annotated property: definition
annotated target: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:pg
database_cross_reference: GOC:txnOH-2018
database_cross_reference: Wikipedia:Transcription_factor

general transcription initiation factor activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: DNA-templated transcription
definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
RO_0002161: NCBITaxon 2
created by: pg
creation date: 2018-05-24T07:51:23Z
has_exact_synonym: GTF activity
has_exact_synonym: basal transcription factor activity
has_exact_synonym: general transcription factor activity
has_obo_namespace: molecular_function
id: GO:0140223
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon
comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.

Axiom
annotated source: general transcription initiation factor activity
annotated property: definition
annotated target: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
database_cross_reference: GOC:txnOH-2018

small molecule sensor activity
type: Class
definition: Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.
created by: pg
creation date: 2018-12-10T14:30:28Z
has_exact_synonym: small molecular sensor activity
has_exact_synonym: small molecule sensing activity
has_obo_namespace: molecular_function
id: GO:0140299
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: small molecule sensor activity
annotated property: definition
annotated target: Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.
database_cross_reference: PMID:26328879

molecular sequestering activity
type: Class
definition: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
created by: pg
creation date: 2019-03-28T10:00:25Z
database_cross_reference: Reactome:R-HSA-3245898
has_obo_namespace: molecular_function
id: GO:0140313
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular sequestering activity
annotated property: definition
annotated target: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
database_cross_reference: PMID:13130076

TCN1 binds correnoids in the circulation
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3245898

ATP-dependent activity
type: Class
subclass of: Restriction
  on property: has part
  some values from: hydrolase activity
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324

carbohydrate derivative metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrate derivative.
created by: bf
creation date: 2012-07-12T04:05:09Z
has_exact_synonym: carbohydrate derivative metabolism
has_obo_namespace: biological_process
id: GO:1901135
in_subset: goslim agr
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrate derivative.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: carbohydrate derivative metabolic process
annotated property: has_exact_synonym
annotated target: carbohydrate derivative metabolism
database_cross_reference: GOC:TermGenie

preceded by
database_cross_reference: BFO:0000062
has_obo_namespace: external
id: preceded_by
shorthand: preceded_by

precedes
database_cross_reference: BFO:0000063
has_obo_namespace: external
id: precedes
shorthand: precedes

results in
created by: cjm
creation date: 2012-03-14T10:35:44Z
database_cross_reference: GOREL:0000040
has_obo_namespace: external
id: results_in
shorthand: results_in
comment: This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.

results in division of
database_cross_reference: GOREL:0001019
has_obo_namespace: external
id: results_in_division_of
shorthand: results_in_division_of
comment: use occurs_in

results in distribution of
database_cross_reference: GOREL:0002003
has_obo_namespace: external
id: results_in_distribution_of
shorthand: results_in_distribution_of

results in fission of
database_cross_reference: GOREL:0002004
has_obo_namespace: external
id: results_in_fission_of
shorthand: results_in_fission_of

results in maintenance of
database_cross_reference: GOREL:0012006
has_obo_namespace: external
id: results_in_maintenance_of
shorthand: results_in_maintenance_of

bearer of
database_cross_reference: RO:0000053
has_obo_namespace: external
id: bearer_of
shorthand: bearer_of

participates in
database_cross_reference: RO:0000056
has_obo_namespace: external
id: participates_in
shorthand: participates_in

has participant
database_cross_reference: RO:0000057
has_obo_namespace: external
id: has_participant
shorthand: has_participant

bounding layer of
database_cross_reference: RO:0002007
has_obo_namespace: external
id: bounding_layer_of
shorthand: bounding_layer_of

coincident with
database_cross_reference: RO:0002008
has_obo_namespace: external
id: coincident_with
shorthand: coincident_with

regulates in other organism
database_cross_reference: RO:0002010
has_obo_namespace: external
id: regulates_in_other_organism
shorthand: regulates_in_other_organism

has regulatory component activity
database_cross_reference: RO:0002013
has_obo_namespace: external
id: has_regulatory_component_activity
shorthand: has_regulatory_component_activity

has negative regulatory component activity
database_cross_reference: RO:0002014
has_obo_namespace: external
id: has_negative_regulatory_component_activity
shorthand: has_negative_regulatory_component_activity

has necessary component activity
database_cross_reference: RO:0002016
has_obo_namespace: external
id: has_necessary_component_activity
shorthand: has_necessary_component_activity

immediately preceded by
database_cross_reference: RO:0002087
has_obo_namespace: external
id: immediately_preceded_by
shorthand: immediately_preceded_by

immediately precedes
database_cross_reference: RO:0002090
has_obo_namespace: external
id: immediately_precedes
shorthand: immediately_precedes

overlaps
database_cross_reference: RO:0002131
has_obo_namespace: external
id: overlaps
shorthand: overlaps

has component
database_cross_reference: RO:0002180
has_obo_namespace: external
id: has_component
shorthand: has_component

capable of
database_cross_reference: RO:0002215
has_obo_namespace: external
id: capable_of
shorthand: capable_of

capable of part of
database_cross_reference: RO:0002216
has_obo_namespace: external
id: capable_of_part_of
shorthand: capable_of_part_of

adjacent to
database_cross_reference: RO:0002220
has_obo_namespace: external
id: adjacent_to
shorthand: adjacent_to

starts with
database_cross_reference: RO:0002224
has_obo_namespace: external
id: starts_with
shorthand: starts_with

ends with
database_cross_reference: RO:0002230
has_obo_namespace: external
id: ends_with
shorthand: ends_with

has start location
database_cross_reference: RO:0002231
has_obo_namespace: external
id: has_start_location
shorthand: has_start_location

has end location
database_cross_reference: RO:0002232
has_obo_namespace: external
id: has_end_location
shorthand: has_end_location

has input
database_cross_reference: RO:0002233
has_obo_namespace: external
id: has_input
shorthand: has_input

has output
database_cross_reference: RO:0002234
has_obo_namespace: external
id: has_output
shorthand: has_output

results in developmental progression of
database_cross_reference: RO:0002295
has_obo_namespace: external
id: results_in_developmental_progression_of
shorthand: results_in_developmental_progression_of

results in development of
database_cross_reference: RO:0002296
has_obo_namespace: external
id: results_in_development_of
shorthand: results_in_development_of

results in formation of
database_cross_reference: RO:0002297
has_obo_namespace: external
id: results_in_formation_of
shorthand: results_in_formation_of

results in morphogenesis of
database_cross_reference: RO:0002298
has_obo_namespace: external
id: results_in_morphogenesis_of
shorthand: results_in_morphogenesis_of

results in maturation of
database_cross_reference: RO:0002299
has_obo_namespace: external
id: results_in_maturation_of
shorthand: results_in_maturation_of

causally upstream of, positive effect
database_cross_reference: RO:0002304
has_obo_namespace: external
id: causally_upstream_of,_positive_effect
shorthand: causally_upstream_of,_positive_effect

causally upstream of, negative effect
database_cross_reference: RO:0002305
has_obo_namespace: external
id: causally_upstream_of,_negative_effect
shorthand: causally_upstream_of,_negative_effect

results in acquisition of features of
database_cross_reference: RO:0002315
has_obo_namespace: external
id: results_in_acquisition_of_features_of
shorthand: results_in_acquisition_of_features_of

regulates levels of
database_cross_reference: RO:0002332
has_obo_namespace: external
id: regulates_levels_of
shorthand: regulates_levels_of

regulated by
database_cross_reference: RO:0002334
has_obo_namespace: external
id: regulated_by
shorthand: regulated_by

negatively regulated by
database_cross_reference: RO:0002335
has_obo_namespace: external
id: negatively_regulated_by
shorthand: negatively_regulated_by

positively regulated by
database_cross_reference: RO:0002336
has_obo_namespace: external
id: positively_regulated_by
shorthand: positively_regulated_by

has target start location
database_cross_reference: RO:0002338
has_obo_namespace: external
id: has_target_start_location
shorthand: has_target_start_location

has target end location
database_cross_reference: RO:0002339
has_obo_namespace: external
id: has_target_end_location
shorthand: has_target_end_location

results in transport along
database_cross_reference: RO:0002341
has_obo_namespace: external
id: results_in_transport_along
shorthand: results_in_transport_along

results in transport across
database_cross_reference: RO:0002342
has_obo_namespace: external
id: results_in_transport_across
shorthand: results_in_transport_across

results in growth of
database_cross_reference: RO:0002343
has_obo_namespace: external
id: results_in_growth_of
shorthand: results_in_growth_of

results in transport to from or in
database_cross_reference: RO:0002344
has_obo_namespace: external
id: results_in_transport_to_from_or_in
shorthand: results_in_transport_to_from_or_in

results in commitment to
database_cross_reference: RO:0002348
has_obo_namespace: external
id: results_in_commitment_to
shorthand: results_in_commitment_to

results in determination of
database_cross_reference: RO:0002349
has_obo_namespace: external
id: results_in_determination_of
shorthand: results_in_determination_of

output of
database_cross_reference: RO:0002353
has_obo_namespace: external
id: output_of
shorthand: output_of

results in structural organization of
database_cross_reference: RO:0002355
has_obo_namespace: external
id: results_in_structural_organization_of
shorthand: results_in_structural_organization_of

results in specification of
database_cross_reference: RO:0002356
has_obo_namespace: external
id: results_in_specification_of
shorthand: results_in_specification_of

causally downstream of
database_cross_reference: RO:0002404
has_obo_namespace: external
id: causally_downstream_of
shorthand: causally_downstream_of

immediately causally downstream of
database_cross_reference: RO:0002405
has_obo_namespace: external
id: immediately_causally_downstream_of
shorthand: immediately_causally_downstream_of

causally upstream of
database_cross_reference: RO:0002411
has_obo_namespace: external
id: causally_upstream_of
shorthand: causally_upstream_of

immediately causally upstream of
database_cross_reference: RO:0002412
has_obo_namespace: external
id: immediately_causally_upstream_of
shorthand: immediately_causally_upstream_of

causally upstream of or within
database_cross_reference: RO:0002418
has_obo_namespace: external
id: causally_upstream_of_or_within
shorthand: causally_upstream_of_or_within

causally downstream of or within
database_cross_reference: RO:0002427
has_obo_namespace: external
id: causally_downstream_of_or_within
shorthand: causally_downstream_of_or_within

has intermediate
database_cross_reference: RO:0002505
has_obo_namespace: external
id: has_intermediate
shorthand: has_intermediate

results in movement of
database_cross_reference: RO:0002565
has_obo_namespace: external
id: results_in_movement_of
shorthand: results_in_movement_of

directly regulates
database_cross_reference: RO:0002578
has_obo_namespace: external
id: directly_regulates
shorthand: directly_regulates

results in assembly of
database_cross_reference: RO:0002588
has_obo_namespace: external
id: results_in_assembly_of
shorthand: results_in_assembly_of

results in disassembly of
database_cross_reference: RO:0002590
has_obo_namespace: external
id: results_in_disassembly_of
shorthand: results_in_disassembly_of

results in remodeling of
database_cross_reference: RO:0002591
has_obo_namespace: external
id: results_in_remodeling_of
shorthand: results_in_remodeling_of

results in organization of
database_cross_reference: RO:0002592
has_obo_namespace: external
id: results_in_organization_of
shorthand: results_in_organization_of

process has causal agent
database_cross_reference: RO:0002608
has_obo_namespace: external
id: process_has_causal_agent
shorthand: process_has_causal_agent

directly positively regulates
database_cross_reference: RO:0002629
has_obo_namespace: external
id: directly_positively_regulates
shorthand: directly_positively_regulates

directly negatively regulates
database_cross_reference: RO:0002630
has_obo_namespace: external
id: directly_negatively_regulates
shorthand: directly_negatively_regulates

produces
database_cross_reference: RO:0003000
has_obo_namespace: external
id: produces
shorthand: produces

produced by
database_cross_reference: RO:0003001
has_obo_namespace: external
id: produced_by
shorthand: produced_by

has primary input or output
database_cross_reference: RO:0004007
has_obo_namespace: external
id: has_primary_input_or_output
shorthand: has_primary_input_or_output

has primary output
database_cross_reference: RO:0004008
has_obo_namespace: external
id: has_primary_output
shorthand: has_primary_output

has primary input
database_cross_reference: RO:0004009
has_obo_namespace: external
id: has_primary_input
shorthand: has_primary_input

has small molecule activator
database_cross_reference: RO:0012001
has_obo_namespace: external
id: has_small_molecule_activator
shorthand: has_small_molecule_activator

acts on population of
database_cross_reference: RO:0012003
has_obo_namespace: external
id: acts_on_population_of
shorthand: acts_on_population_of

results in fusion of
database_cross_reference: RO:0012008
has_obo_namespace: external
id: results_in_fusion_of
shorthand: results_in_fusion_of

regulates characteristic
database_cross_reference: RO:0019000
has_obo_namespace: gene_ontology
id: regulates_characteristic
shorthand: regulates_characteristic

positively regulates characteristic
database_cross_reference: RO:0019001
has_obo_namespace: gene_ontology
id: positively_regulates_characteristic
shorthand: positively_regulates_characteristic

negatively regulates characteristic
database_cross_reference: RO:0019002
has_obo_namespace: gene_ontology
id: negatively_regulates_characteristic
shorthand: negatively_regulates_characteristic

results in changes to anatomical or cellular structure
database_cross_reference: RO:0040036
has_obo_namespace: external
id: results_in_changes_to_anatomical_or_cellular_structure
shorthand: results_in_changes_to_anatomical_or_cellular_structure