format-version: 1.2
data-version: go/2024-09-26/subsets/gocheck_do_not_annotate.owl
subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3."
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_obsoletion_candidate "Terms planned for obsoletion"
subsetdef: goslim_agr "AGR slim"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_chembl "ChEMBL protein targets summary"
subsetdef: goslim_drosophila "Drosophila GO slim"
subsetdef: goslim_euk_cellular_processes_ribbon "GO ribbon for eukaroytic cellular processes"
subsetdef: goslim_flybase_ribbon "Insecta GO ribbon slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_mouse "Mouse GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_plant_ribbon "Plant GO ribbon"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_prokaryote "GO subset for prokaryotes"
subsetdef: goslim_prokaryote_ribbon "Prokaryote GO ribbon slim"
subsetdef: goslim_synapse "synapse GO slim"
subsetdef: goslim_virus "GO subset for viruses"
subsetdef: goslim_yeast "Yeast GO slim"
synonymtypedef: syngo_official_label "label approved by the SynGO project"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
ontology: go/subsets/gocheck_do_not_annotate
property_value: owl:versionInfo "2024-09-26" xsd:string

[Term]
id: GO:0000075
name: cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0031576
alt_id: GO:0071779
alt_id: GO:0072395
alt_id: GO:0072404
alt_id: GO:0072407
def: "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle]
comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.
subset: gocheck_do_not_annotate
synonym: "cell cycle checkpoint" EXACT []
synonym: "G1/S checkpoint" NARROW []
synonym: "G1/S transition checkpoint" NARROW []
synonym: "G2/M checkpoint" NARROW []
synonym: "G2/M transition checkpoint" NARROW []
synonym: "signal transduction involved in cell cycle checkpoint" EXACT []
synonym: "signal transduction involved in G2/M transition checkpoint" EXACT []
xref: Wikipedia:Cell_cycle_checkpoint
is_a: GO:0009987 ! cellular process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0007049 ! cell cycle
relationship: negatively_regulates GO:0022402 ! cell cycle process
relationship: occurs_in GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0050789 ! regulation of biological process
relationship: part_of GO:0051716 ! cellular response to stimulus
relationship: regulates GO:0007049 ! cell cycle
relationship: regulates GO:0022402 ! cell cycle process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20935" xsd:anyURI

[Term]
id: GO:0000080
name: mitotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of mitotic cell cycle" EXACT []
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000084
name: mitotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S phase of mitotic cell cycle" EXACT []
synonym: "S-phase of mitotic cell cycle" EXACT []
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000085
name: mitotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of mitotic cell cycle" EXACT []
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051329 ! mitotic interphase

[Term]
id: GO:0000087
name: mitotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of mitotic cell cycle" EXACT []
synonym: "M-phase of mitotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098763 ! mitotic cell cycle phase

[Term]
id: GO:0000088
name: mitotic prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000089
name: mitotic metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000090
name: mitotic anaphase
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051322 ! anaphase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000091
name: mitotic anaphase A
namespace: biological_process
def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000092
name: mitotic anaphase B
namespace: biological_process
def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000093
name: mitotic telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
relationship: part_of GO:0000087 ! mitotic M phase

[Term]
id: GO:0000236
name: mitotic prometaphase
namespace: biological_process
def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0000087 ! mitotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24374" xsd:anyURI

[Term]
id: GO:0000237
name: leptotene
namespace: biological_process
def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Leptotene
xref: Wikipedia:Meiosis#Leptotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000238
name: zygotene
namespace: biological_process
def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Zygotene
xref: Wikipedia:Zygotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000239
name: pachytene
namespace: biological_process
def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Meiosis#Pachytene
xref: Wikipedia:Pachytene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000240
name: diplotene
namespace: biological_process
def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diplotene
xref: Wikipedia:Meiosis#Diplotene
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000241
name: diakinesis
namespace: biological_process
def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Diakinesis
xref: Wikipedia:Meiosis#Diakinesis
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
alt_id: GO:0033205
def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "cell cycle cytokinesis" EXACT []
synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Cytokinesis
is_a: GO:0022402 ! cell cycle process
relationship: has_part GO:0016043 ! cellular component organization

[Term]
id: GO:0001101
name: response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
alt_id: GO:0042032
alt_id: GO:0042089
alt_id: GO:0042107
alt_id: GO:0050663
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cytokine biosynthetic process" NARROW []
synonym: "cytokine metabolic process" NARROW []
synonym: "cytokine secretion" NARROW []
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0032501 ! multicellular organismal process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19116" xsd:anyURI

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002374
alt_id: GO:0002375
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cytokine biosynthetic process involved in immune response" NARROW []
synonym: "cytokine production during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion involved in immune response" RELATED []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0050896 ! response to stimulus

[Term]
id: GO:0002368
name: B cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002377
name: immunoglobulin production
namespace: biological_process
alt_id: GO:0002378
alt_id: GO:0048305
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production" EXACT []
synonym: "immunoglobulin biosynthetic process" NARROW []
synonym: "immunoglobulin secretion" NARROW []
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002381
name: immunoglobulin production involved in immunoglobulin-mediated immune response
namespace: biological_process
alt_id: GO:0002379
alt_id: GO:0002380
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production during immune response" RELATED []
synonym: "antibody secretion during immune response" RELATED []
synonym: "immunoglobulin biosynthetic process involved in immune response" NARROW []
synonym: "immunoglobulin production during immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immunoglobulin mediated immune response" EXACT []
synonym: "immunoglobulin secretion involved in immune response" NARROW []
is_a: GO:0002377 ! immunoglobulin production
relationship: part_of GO:0050896 ! response to stimulus

[Term]
id: GO:0002426
name: immunoglobulin production in mucosal tissue
namespace: biological_process
def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "antibody production in mucosal tissue" EXACT []
is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
subset: gocheck_do_not_annotate
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
relationship: part_of GO:0050896 ! response to stimulus

[Term]
id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0009605 ! response to external stimulus
relationship: part_of GO:0009607 ! response to biotic stimulus
relationship: part_of GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009607 ! response to biotic stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [PMID:15761036]
subset: gocheck_do_not_annotate
synonym: "11beta-hydroxy steroid dehydrogenase" RELATED []
synonym: "11beta-hydroxysteroid dehydrogenase" RELATED []
synonym: "beta-hydroxysteroid dehydrogenase" BROAD []
synonym: "corticosteroid 11-reductase" RELATED []
synonym: "corticosteroid 11beta-dehydrogenase" RELATED []
xref: Reactome:R-HSA-194023 "HSD11B2,HSD11B1 dimer oxidise CORT to COR"
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21915" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28173" xsd:anyURI

[Term]
id: GO:0004448
name: isocitrate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H." [GOC:curators]
subset: gocheck_do_not_annotate
synonym: "IDH activity" RELATED []
synonym: "IDP activity" RELATED []
synonym: "isocitrate dehydrogenase activity" EXACT []
synonym: "isocitric acid dehydrogenase activity" EXACT []
synonym: "isocitric dehydrogenase activity" EXACT []
synonym: "oxalosuccinate carboxylase activity" EXACT []
synonym: "oxalosuccinate decarboxylase activity" EXACT []
synonym: "oxalosuccinic decarboxylase activity" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23235" xsd:anyURI

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf]
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "carrier" RELATED []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27621" xsd:anyURI

[Term]
id: GO:0005368
name: taurine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai]
subset: gocheck_do_not_annotate
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0006810 ! transport
relationship: part_of GO:0009987 ! cellular process

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, ISBN:0198547684, PMID:15134259, Wikipedia:Microbial_cyst]
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
xref: Wikipedia:Cell_wall
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110165 ! cellular anatomical structure
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21669" xsd:anyURI

[Term]
id: GO:0005622
name: intracellular anatomical structure
namespace: cellular_component
def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "internal to cell" EXACT []
synonym: "intracellular" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0110165 ! cellular anatomical structure
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17776" xsd:anyURI

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
alt_id: GO:0044765
def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "single-organism transport" RELATED []
is_a: GO:0051234 ! establishment of localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20292" xsd:anyURI
created_by: jl
creation_date: 2012-12-13T16:25:32Z

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
alt_id: GO:1902589
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "organelle organisation" EXACT []
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
synonym: "single organism organelle organization" EXACT [GOC:TermGenie]
synonym: "single-organism organelle organization" RELATED []
is_a: GO:0016043 ! cellular component organization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI
created_by: jl
creation_date: 2013-12-19T15:25:51Z

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007093
name: mitotic cell cycle checkpoint signaling
namespace: biological_process
alt_id: GO:0031575
alt_id: GO:0071780
alt_id: GO:0072413
alt_id: GO:0072456
alt_id: GO:0072474
def: "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
synonym: "mitotic cell cycle checkpoint" EXACT []
synonym: "mitotic checkpoint" RELATED []
synonym: "signal transduction involved in mitotic cell cycle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle G1/S checkpoint" NARROW []
synonym: "signal transduction involved in mitotic G2/M transition checkpoint" NARROW []
is_a: GO:0000075 ! cell cycle checkpoint signaling
is_a: GO:1903047 ! mitotic cell cycle process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20935" xsd:anyURI

[Term]
id: GO:0007128
name: meiotic prophase I
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007132
name: meiotic metaphase I
namespace: biological_process
def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051323 ! metaphase
relationship: part_of GO:0051327 ! meiotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25408" xsd:anyURI

[Term]
id: GO:0007133
name: meiotic anaphase I
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051322 ! anaphase
relationship: part_of GO:0051327 ! meiotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25408" xsd:anyURI

[Term]
id: GO:0007134
name: meiotic telophase I
namespace: biological_process
def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007136
name: meiotic prophase II
namespace: biological_process
def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051324 ! prophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007137
name: meiotic metaphase II
namespace: biological_process
def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051323 ! metaphase
is_a: GO:0098765 ! meiosis II cell cycle phase
relationship: part_of GO:0051327 ! meiotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25408" xsd:anyURI

[Term]
id: GO:0007138
name: meiotic anaphase II
namespace: biological_process
def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098765 ! meiosis II cell cycle phase
relationship: part_of GO:0051322 ! anaphase
relationship: part_of GO:0051327 ! meiotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25408" xsd:anyURI

[Term]
id: GO:0007139
name: meiotic telophase II
namespace: biological_process
def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098765 ! meiosis II cell cycle phase

[Term]
id: GO:0007275
name: multicellular organism development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048856 ! anatomical structure development
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21234" xsd:anyURI

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: gocheck_do_not_annotate
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0032501 ! multicellular organismal process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
alt_id: GO:0023032
alt_id: GO:0044708
alt_id: GO:0044709
def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
synonym: "single-organism behavior" RELATED []
xref: Wikipedia:Behavior
is_a: GO:0032501 ! multicellular organismal process
created_by: jl
creation_date: 2012-09-20T14:06:08Z

[Term]
id: GO:0008134
name: transcription factor binding
namespace: molecular_function
def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "TF binding" EXACT []
synonym: "transcription regulator binding" RELATED []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19354" xsd:anyURI

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
alt_id: GO:0044236
alt_id: GO:0044710
def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote_ribbon
synonym: "metabolism" EXACT []
xref: Wikipedia:Metabolism
is_a: GO:0009987 ! cellular process
disjoint_from: GO:0044848 ! biological phase
disjoint_from: GO:0051179 ! localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28932" xsd:anyURI
created_by: jl
creation_date: 2012-10-17T15:46:40Z

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]
comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
subset: gocheck_do_not_annotate
synonym: "accidental cell death" RELATED []
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI

[Term]
id: GO:0008452
name: RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another." [GOC:mah]
subset: gocheck_do_not_annotate
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27418" xsd:anyURI

[Term]
id: GO:0008937
name: ferredoxin-NAD(P) reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [GOC:curators]
subset: gocheck_do_not_annotate
synonym: "ferredoxin reductase activity" BROAD []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21649" xsd:anyURI

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/15249" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25418" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_plant
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/16572" xsd:anyURI

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_plant
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009790
name: embryo development
namespace: biological_process
alt_id: GO:0009795
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Wikipedia:Embryogenesis
is_a: GO:0007275 ! multicellular organism development

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0044763
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
subset: goslim_plant
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
synonym: "single-organism cellular process" RELATED []
disjoint_from: GO:0044848 ! biological phase
created_by: jl
creation_date: 2012-12-11T16:56:55Z

[Term]
id: GO:0010835
name: regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0010836
name: negative regulation of protein ADP-ribosylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf]
is_a: GO:0010835 ! regulation of protein ADP-ribosylation
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:0010934
name: macrophage cytokine production
namespace: biological_process
def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0014076
name: response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:ef, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to selective serotonin reuptake inhibitor" RELATED []
synonym: "response to SSRI" RELATED []
is_a: GO:0036276 ! response to antidepressant

[Term]
id: GO:0015318
name: inorganic molecular entity transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729]
subset: gocheck_do_not_annotate
synonym: "inorganic solute uptake transmembrane transporter activity" EXACT []
synonym: "inorganic uptake permease activity" EXACT []
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0006810 ! transport
relationship: part_of GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14372" xsd:anyURI

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
alt_id: GO:0044235
alt_id: GO:0071842
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
synonym: "cellular component organisation at cellular level" EXACT [GOC:mah]
synonym: "cellular component organisation in other organism" EXACT [GOC:mah]
synonym: "cellular component organization at cellular level" EXACT []
synonym: "cellular component organization in other organism" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
alt_id: GO:0048591
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0040007 ! growth

[Term]
id: GO:0016631
name: enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [GOC:rb]
comment: This term should not be used for direct annotation; please use of the children that specifies the cofactor of the reaction (NAD+ or NADP+): enoyl-[acyl-carrier-protein] reductase (NADH) activity ; GO:0004318 or enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.
subset: gocheck_do_not_annotate
synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "enoyl-[acyl-carrier-protein] reductase activity" BROAD []
synonym: "enoyl-ACP reductase activity" EXACT []
synonym: "enoyl-acyl carrier protein reductase" EXACT []
xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25307" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28526" xsd:anyURI

[Term]
id: GO:0017186
name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031]
comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'.
subset: gocheck_do_not_annotate
synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT []
synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT []
synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT []
xref: RESID:AA0031
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018061
name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
namespace: biological_process
def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128]
subset: gocheck_do_not_annotate
synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT []
xref: RESID:AA0128
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018083
name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
namespace: biological_process
def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185]
subset: gocheck_do_not_annotate
synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT []
xref: RESID:AA0185
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018085
name: peptidyl-L-amino acid racemization
namespace: biological_process
def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma]
subset: gocheck_do_not_annotate
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018193
name: peptidyl-amino acid modification
namespace: biological_process
def: "The alteration of an amino acid residue in a peptide." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_yeast
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0018231
name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107]
subset: gocheck_do_not_annotate
synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0107
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018339
name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232]
subset: gocheck_do_not_annotate
synonym: "peptidyl-aspartic acid methylthiolation" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0232
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0019122
name: peptidyl-D-alanine racemization
namespace: biological_process
def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191]
comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'.
subset: gocheck_do_not_annotate
synonym: "alanine racemization" BROAD []
xref: RESID:AA0191
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
alt_id: GO:0044267
alt_id: GO:0044268
def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cellular protein metabolic process" EXACT []
synonym: "cellular protein metabolism" EXACT []
synonym: "multicellular organismal protein metabolic process" NARROW []
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0007049 ! cell cycle
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0022403
name: cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
alt_id: GO:0071845
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cell structure disassembly" EXACT []
synonym: "cellular component disassembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0022413
name: reproductive process in single-celled organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete]
subset: gocheck_do_not_annotate
is_a: GO:0022414 ! reproductive process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
alt_id: GO:0044702
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "single organism reproductive process" RELATED []
xref: Wikipedia:Reproduction
disjoint_from: GO:0044848 ! biological phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI
created_by: jl
creation_date: 2012-09-19T15:56:06Z

[Term]
id: GO:0022601
name: menstrual cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0030242
name: autophagy of peroxisome
namespace: biological_process
def: "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]
subset: gocheck_do_not_annotate
synonym: "peroxisome degradation" BROAD []
synonym: "peroxisome disassembly" BROAD []
synonym: "pexophagy" RELATED []
is_a: GO:0008152 ! metabolic process
is_a: GO:0061919 ! process utilizing autophagic mechanism
relationship: has_part GO:0006810 ! transport
relationship: has_part GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25541" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26190" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28542" xsd:anyURI

[Term]
id: GO:0031074
name: nucleocytoplasmic transport complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "nucleocytoplasmic shuttling complex" NARROW []

[Term]
id: GO:0031323
name: regulation of cellular metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "regulation of cellular metabolism" EXACT []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044237 ! cellular metabolic process
relationship: regulates GO:0044237 ! cellular metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031324
name: negative regulation of cellular metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular metabolic process" EXACT []
synonym: "down-regulation of cellular metabolic process" EXACT []
synonym: "downregulation of cellular metabolic process" EXACT []
synonym: "inhibition of cellular metabolic process" NARROW []
synonym: "negative regulation of cellular metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process
relationship: negatively_regulates GO:0044237 ! cellular metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031325
name: positive regulation of cellular metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of cellular metabolic process" NARROW []
synonym: "positive regulation of cellular metabolism" EXACT []
synonym: "stimulation of cellular metabolic process" NARROW []
synonym: "up regulation of cellular metabolic process" EXACT []
synonym: "up-regulation of cellular metabolic process" EXACT []
synonym: "upregulation of cellular metabolic process" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044237 ! cellular metabolic process
relationship: positively_regulates GO:0044237 ! cellular metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031326
name: regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "regulation of cellular anabolism" EXACT []
synonym: "regulation of cellular biosynthesis" EXACT []
synonym: "regulation of cellular formation" EXACT []
synonym: "regulation of cellular synthesis" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044249 ! cellular biosynthetic process
relationship: regulates GO:0044249 ! cellular biosynthetic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031327
name: negative regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular biosynthetic process" EXACT []
synonym: "down-regulation of cellular biosynthetic process" EXACT []
synonym: "downregulation of cellular biosynthetic process" EXACT []
synonym: "inhibition of cellular biosynthetic process" NARROW []
synonym: "negative regulation of cellular anabolism" EXACT []
synonym: "negative regulation of cellular biosynthesis" EXACT []
synonym: "negative regulation of cellular formation" EXACT []
synonym: "negative regulation of cellular synthesis" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process
relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031328
name: positive regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of cellular biosynthetic process" NARROW []
synonym: "positive regulation of cellular anabolism" EXACT []
synonym: "positive regulation of cellular biosynthesis" EXACT []
synonym: "positive regulation of cellular formation" EXACT []
synonym: "positive regulation of cellular synthesis" EXACT []
synonym: "stimulation of cellular biosynthetic process" NARROW []
synonym: "up regulation of cellular biosynthetic process" EXACT []
synonym: "up-regulation of cellular biosynthetic process" EXACT []
synonym: "upregulation of cellular biosynthetic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process
relationship: positively_regulates GO:0044249 ! cellular biosynthetic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031329
name: regulation of cellular catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "regulation of cellular breakdown" EXACT []
synonym: "regulation of cellular catabolism" EXACT []
synonym: "regulation of cellular degradation" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031330
name: negative regulation of cellular catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular catabolic process" EXACT []
synonym: "down-regulation of cellular catabolic process" EXACT []
synonym: "downregulation of cellular catabolic process" EXACT []
synonym: "inhibition of cellular catabolic process" NARROW []
synonym: "negative regulation of cellular breakdown" EXACT []
synonym: "negative regulation of cellular catabolism" EXACT []
synonym: "negative regulation of cellular degradation" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031331
name: positive regulation of cellular catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of cellular catabolic process" NARROW []
synonym: "positive regulation of cellular breakdown" EXACT []
synonym: "positive regulation of cellular catabolism" EXACT []
synonym: "positive regulation of cellular degradation" EXACT []
synonym: "stimulation of cellular catabolic process" NARROW []
synonym: "up regulation of cellular catabolic process" EXACT []
synonym: "up-regulation of cellular catabolic process" EXACT []
synonym: "upregulation of cellular catabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0031577
name: spindle checkpoint signaling
namespace: biological_process
alt_id: GO:0072416
def: "A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.
subset: gocheck_do_not_annotate
synonym: "signal transduction involved in spindle checkpoint" EXACT []
synonym: "spindle checkpoint" EXACT []
xref: Wikipedia:Spindle_checkpoint
is_a: GO:0000075 ! cell cycle checkpoint signaling
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20935" xsd:anyURI

[Term]
id: GO:0032091
name: negative regulation of protein binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of protein binding" EXACT []
synonym: "down-regulation of protein binding" EXACT []
synonym: "downregulation of protein binding" EXACT []
synonym: "inhibition of protein binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0032092
name: positive regulation of protein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of protein binding" NARROW []
synonym: "stimulation of protein binding" NARROW []
synonym: "up regulation of protein binding" EXACT []
synonym: "up-regulation of protein binding" EXACT []
synonym: "upregulation of protein binding" EXACT []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009605 ! response to external stimulus
relationship: regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009605 ! response to external stimulus
relationship: negatively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009605 ! response to external stimulus
relationship: positively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0044707
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
synonym: "single-multicellular organism process" RELATED []
disjoint_from: GO:0044848 ! biological phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI
created_by: jl
creation_date: 2012-09-19T16:07:47Z

[Term]
id: GO:0032601
name: connective tissue growth factor production
namespace: biological_process
def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CCN2 production" EXACT []
synonym: "CTGF production" EXACT []
synonym: "Fisp12 production" EXACT []
synonym: "Hcs24 production" EXACT []
synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "IGFBP8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032602
name: chemokine production
namespace: biological_process
alt_id: GO:0042033
alt_id: GO:0050755
alt_id: GO:0090195
def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine]
subset: gocheck_do_not_annotate
synonym: "chemokine anabolism" EXACT []
synonym: "chemokine biosynthesis" EXACT []
synonym: "chemokine biosynthetic process" NARROW []
synonym: "chemokine formation" EXACT []
synonym: "chemokine metabolic process" NARROW []
synonym: "chemokine secretion" NARROW []
synonym: "chemokine synthesis" EXACT []
is_a: GO:0001816 ! cytokine production
creation_date: 2009-12-18T11:26:20Z

[Term]
id: GO:0032603
name: fractalkine production
namespace: biological_process
alt_id: GO:0050751
alt_id: GO:0050754
alt_id: GO:0050756
def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:12729461]
subset: gocheck_do_not_annotate
synonym: "ABCD-3 production" EXACT []
synonym: "CX3CL1 production" EXACT []
synonym: "fractalkine biosynthetic process" NARROW []
synonym: "fractalkine metabolic process" NARROW []
synonym: "neurotactin production" EXACT []
is_a: GO:0032602 ! chemokine production
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19254" xsd:anyURI

[Term]
id: GO:0032604
name: granulocyte macrophage colony-stimulating factor production
namespace: biological_process
alt_id: GO:0042253
def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, ISBN:0198506732]
subset: gocheck_do_not_annotate
synonym: "GM-CSF production" EXACT [GOC:vk]
synonym: "granulocyte macrophage colony stimulating factor production" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
is_a: GO:0001816 ! cytokine production
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0032605
name: hepatocyte growth factor production
namespace: biological_process
alt_id: GO:0048175
def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:1838014]
subset: gocheck_do_not_annotate
synonym: "hepatocyte growth factor biosynthetic process" NARROW []
synonym: "HGF production" EXACT []
synonym: "scatter factor production" EXACT []
is_a: GO:0001816 ! cytokine production
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0032606
name: type I interferon production
namespace: biological_process
alt_id: GO:0045351
alt_id: GO:0072641
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "interferon type I production" EXACT []
synonym: "type I IFN production" EXACT [GOC:mah]
synonym: "type I interferon biosynthetic process" NARROW []
synonym: "type I interferon secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032607
name: interferon-alpha production
namespace: biological_process
alt_id: GO:0045349
alt_id: GO:0072642
def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-alpha production" EXACT [GOC:mah]
synonym: "IFNA production" EXACT [GOC:mah]
synonym: "interferon-alpha biosynthetic process" NARROW []
synonym: "interferon-alpha secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032608
name: interferon-beta production
namespace: biological_process
alt_id: GO:0035546
alt_id: GO:0045350
def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-beta production" EXACT []
synonym: "IFNB production" EXACT [GOC:mah]
synonym: "interferon-beta biosynthetic process" NARROW []
synonym: "interferon-beta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032609
name: type II interferon production
namespace: biological_process
alt_id: GO:0042095
alt_id: GO:0072643
def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
subset: gocheck_do_not_annotate
synonym: "IFNG production" EXACT [GOC:mah]
synonym: "interferon-gamma biosynthetic process" NARROW []
synonym: "interferon-gamma production" EXACT []
synonym: "interferon-gamma secretion" NARROW []
synonym: "type II IFN production" EXACT [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032610
name: interleukin-1 alpha production
namespace: biological_process
alt_id: GO:0050703
alt_id: GO:0050719
def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 alpha production" EXACT []
synonym: "interleukin-1 alpha biosynthetic process" NARROW []
synonym: "interleukin-1 alpha secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032611
name: interleukin-1 beta production
namespace: biological_process
alt_id: GO:0050702
alt_id: GO:0050720
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 beta production" EXACT []
synonym: "interleukin-1 beta biosynthetic process" NARROW []
synonym: "interleukin-1 beta secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
namespace: biological_process
alt_id: GO:0042222
alt_id: GO:0050701
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-1 production" EXACT []
synonym: "interleukin-1 biosynthetic process" NARROW []
synonym: "interleukin-1 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
namespace: biological_process
alt_id: GO:0042091
alt_id: GO:0072608
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-10 production" EXACT []
synonym: "interleukin-10 biosynthetic process" NARROW []
synonym: "interleukin-10 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032614
name: interleukin-11 production
namespace: biological_process
alt_id: GO:0042230
alt_id: GO:0072609
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-11 production" EXACT []
synonym: "interleukin-11 biosynthetic process" NARROW []
synonym: "interleukin-11 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032615
name: interleukin-12 production
namespace: biological_process
alt_id: GO:0042090
alt_id: GO:0072610
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CLMF production" NARROW [GOC:BHF]
synonym: "IL-12 production" EXACT []
synonym: "interleukin-12 biosynthetic process" NARROW []
synonym: "interleukin-12 secretion" NARROW []
synonym: "NKSF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
namespace: biological_process
alt_id: GO:0042231
alt_id: GO:0072611
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-13 production" EXACT []
synonym: "interleukin-13 biosynthetic process" NARROW []
synonym: "interleukin-13 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032618
name: interleukin-15 production
namespace: biological_process
alt_id: GO:0042233
alt_id: GO:0072613
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-15 production" EXACT []
synonym: "interleukin-15 biosynthetic process" NARROW []
synonym: "interleukin-15 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032619
name: interleukin-16 production
namespace: biological_process
alt_id: GO:0042234
alt_id: GO:0072614
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-16 production" EXACT []
synonym: "interleukin-16 biosynthetic process" NARROW []
synonym: "interleukin-16 secretion" NARROW []
synonym: "LCF production" NARROW [GOC:BHF]
synonym: "pro-interleukin-16 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
namespace: biological_process
alt_id: GO:0042235
alt_id: GO:0072615
def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17]
subset: gocheck_do_not_annotate
synonym: "CTLA-8 production" EXACT [GOC:BHF]
synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF]
synonym: "IL-17 production" EXACT []
synonym: "interleukin-17 biosynthetic process" NARROW []
synonym: "interleukin-17 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032621
name: interleukin-18 production
namespace: biological_process
alt_id: GO:0042241
alt_id: GO:0072616
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IGIF production" EXACT [GOC:BHF]
synonym: "IL-18 production" EXACT []
synonym: "IL1F4 production" NARROW [GOC:BHF]
synonym: "interleukin-18 biosynthetic process" NARROW []
synonym: "interleukin-18 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032622
name: interleukin-19 production
namespace: biological_process
alt_id: GO:0042236
alt_id: GO:0072617
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-19 production" EXACT []
synonym: "IL-19 secretion" NARROW [GOC:BHF]
synonym: "interleukin-19 biosynthetic process" NARROW []
synonym: "interleukin-19 secretion" NARROW []
synonym: "ZMDA1 secretion" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
namespace: biological_process
alt_id: GO:0042094
alt_id: GO:0070970
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-2 production" EXACT []
synonym: "interleukin-2 biosynthetic process" NARROW []
synonym: "interleukin-2 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032624
name: interleukin-20 production
namespace: biological_process
alt_id: GO:0042237
alt_id: GO:0072618
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-20 production" EXACT []
synonym: "interleukin-20 biosynthetic process" NARROW []
synonym: "interleukin-20 secretion" NARROW []
synonym: "ZCYTO10 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032625
name: interleukin-21 production
namespace: biological_process
alt_id: GO:0042238
alt_id: GO:0072619
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-21 production" EXACT []
synonym: "interleukin-21 biosynthetic process" NARROW []
synonym: "interleukin-21 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
namespace: biological_process
alt_id: GO:0042239
alt_id: GO:0072620
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-22 production" EXACT []
synonym: "IL22 production" EXACT [GOC:BHF]
synonym: "ILTIF production" EXACT [GOC:BHF]
synonym: "interleukin-22 biosynthetic process" NARROW []
synonym: "interleukin-22 secretion" NARROW []
synonym: "ZCYTO18 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032627
name: interleukin-23 production
namespace: biological_process
alt_id: GO:0042240
alt_id: GO:0072621
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-23 production" EXACT []
synonym: "interleukin-23 biosynthetic process" NARROW []
synonym: "interleukin-23 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032628
name: interleukin-24 production
namespace: biological_process
alt_id: GO:0045524
alt_id: GO:0072622
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-24 production" EXACT []
synonym: "interleukin-24 biosynthetic process" NARROW []
synonym: "interleukin-24 secretion" NARROW []
synonym: "MDA7 production" NARROW [GOC:BHF]
synonym: "ST16 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032629
name: interleukin-25 production
namespace: biological_process
alt_id: GO:0045525
alt_id: GO:0072623
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-25 production" EXACT []
synonym: "IL-25 secretion" NARROW [GOC:BHF]
synonym: "IL17E secretion" NARROW [GOC:BHF]
synonym: "interleukin-25 anabolism" NARROW []
synonym: "interleukin-25 biosynthesis" NARROW []
synonym: "interleukin-25 biosynthetic process" NARROW []
synonym: "interleukin-25 formation" NARROW []
synonym: "interleukin-25 secretion" NARROW []
synonym: "interleukin-25 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032630
name: interleukin-26 production
namespace: biological_process
alt_id: GO:0045526
alt_id: GO:0072624
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "AK155 secretion" NARROW [GOC:BHF]
synonym: "IL-26 production" EXACT []
synonym: "interleukin-26 anabolism" NARROW []
synonym: "interleukin-26 biosynthesis" NARROW []
synonym: "interleukin-26 biosynthetic process" NARROW []
synonym: "interleukin-26 formation" NARROW []
synonym: "interleukin-26 secretion" NARROW []
synonym: "interleukin-26 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032631
name: interleukin-27 production
namespace: biological_process
alt_id: GO:0045527
alt_id: GO:0072625
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-27 production" EXACT []
synonym: "interleukin-27 biosynthetic process" NARROW []
synonym: "interleukin-27 formation" NARROW []
synonym: "interleukin-27 secretion" NARROW []
synonym: "interleukin-27 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032632
name: interleukin-3 production
namespace: biological_process
alt_id: GO:0042223
alt_id: GO:0072601
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-3 production" EXACT []
synonym: "interleukin-3 biosynthetic process" NARROW []
synonym: "interleukin-3 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
namespace: biological_process
alt_id: GO:0042097
alt_id: GO:0042224
alt_id: GO:0072602
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-4 production" EXACT []
synonym: "interleukin-4 biosynthetic process" NARROW []
synonym: "interleukin-4 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
namespace: biological_process
alt_id: GO:0042225
alt_id: GO:0072603
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-5 production" EXACT []
synonym: "interleukin-5 biosynthetic process" NARROW []
synonym: "interleukin-5 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
namespace: biological_process
alt_id: GO:0042226
alt_id: GO:0072604
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-6 production" EXACT []
synonym: "interleukin-6 biosynthetic process" NARROW []
synonym: "interleukin-6 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032636
name: interleukin-7 production
namespace: biological_process
alt_id: GO:0042227
alt_id: GO:0072605
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-7 production" EXACT []
synonym: "interleukin-7 biosynthetic process" NARROW []
synonym: "interleukin-7 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
namespace: biological_process
alt_id: GO:0042228
alt_id: GO:0072606
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-8 production" EXACT []
synonym: "interleukin-8 biosynthetic process" NARROW []
synonym: "interleukin-8 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
namespace: biological_process
alt_id: GO:0042229
alt_id: GO:0072607
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-9 production" EXACT []
synonym: "interleukin-9 biosynthetic process" NARROW []
synonym: "interleukin-9 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032639
name: TRAIL production
namespace: biological_process
alt_id: GO:0045553
def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9311998]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "TRAIL biosynthetic process" NARROW []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042533
alt_id: GO:1990774
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:mah, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cachectin production" EXACT []
synonym: "TNF alpha biosynthesis" NARROW []
synonym: "TNF biosynthesis" NARROW []
synonym: "TNF biosynthetic process" NARROW []
synonym: "TNF production" EXACT []
synonym: "TNF-alpha biosynthesis" NARROW []
synonym: "TNF-alpha biosynthetic process" NARROW []
synonym: "TNF-alpha production" RELATED []
synonym: "Tnfa production" RELATED []
synonym: "tumor necrosis factor anabolism" NARROW []
synonym: "tumor necrosis factor biosynthesis" NARROW []
synonym: "tumor necrosis factor biosynthetic process" NARROW []
synonym: "tumor necrosis factor formation" NARROW []
synonym: "tumor necrosis factor secretion" NARROW []
synonym: "tumor necrosis factor synthesis" NARROW []
synonym: "tumor necrosis factor-alpha production" RELATED []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: sl
creation_date: 2015-06-15T22:59:26Z

[Term]
id: GO:0032641
name: lymphotoxin A production
namespace: biological_process
alt_id: GO:0042109
def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "LTA production" EXACT []
synonym: "lymphotoxin A biosynthetic process" NARROW []
synonym: "lymphotoxin A formation" RELATED []
synonym: "lymphotoxin A synthesis" NARROW []
synonym: "lymphotoxin-alpha production" EXACT []
synonym: "TNF-B production" EXACT []
synonym: "TNF-beta production" EXACT []
synonym: "tumor necrosis factor-beta production" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

[Term]
id: GO:0032762
name: mast cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
alt_id: GO:0062103
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
subset: gocheck_do_not_annotate
synonym: "double-stranded RNA biosynthesis" NARROW []
synonym: "double-stranded RNA biosynthetic process" NARROW []
synonym: "dsRNA biosynthesis" NARROW []
synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl]
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0141187 ! nucleic acid biosynthetic process

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of localisation" EXACT [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051179 ! localization
relationship: regulates GO:0051179 ! localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0033341
name: regulation of collagen binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0033342
name: negative regulation of collagen binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of collagen binding" EXACT []
synonym: "down-regulation of collagen binding" EXACT []
synonym: "downregulation of collagen binding" EXACT []
synonym: "inhibition of collagen binding" NARROW []
is_a: GO:0033341 ! regulation of collagen binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0033343
name: positive regulation of collagen binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of collagen binding" NARROW []
synonym: "stimulation of collagen binding" NARROW []
synonym: "up regulation of collagen binding" EXACT []
synonym: "up-regulation of collagen binding" EXACT []
synonym: "upregulation of collagen binding" EXACT []
is_a: GO:0033341 ! regulation of collagen binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0033643
name: host cell part
namespace: cellular_component
def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0033646
name: host intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "host cell intracellular part" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033643 ! host cell part

[Term]
id: GO:0033653
name: host cell chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "host chloroplast component" EXACT []
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0033655
name: host cell cytoplasm part
namespace: cellular_component
def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cytoplasm component" BROAD []
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0033646 ! host intracellular part

[Term]
id: GO:0035393
name: chemokine (C-X-C motif) ligand 9 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
subset: gocheck_do_not_annotate
synonym: "CXCL9 production" EXACT []
synonym: "MIG production" EXACT []
synonym: "Monokine induced by gamma interferon production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: bf
creation_date: 2010-03-23T10:03:20Z

[Term]
id: GO:0035530
name: chemokine (C-C motif) ligand 6 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544]
subset: gocheck_do_not_annotate
synonym: "CCL6 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: bf
creation_date: 2010-05-07T10:21:15Z

[Term]
id: GO:0035561
name: regulation of chromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
created_by: bf
creation_date: 2010-05-19T10:28:36Z

[Term]
id: GO:0035562
name: negative regulation of chromatin binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051100 ! negative regulation of binding
created_by: bf
creation_date: 2010-05-19T10:29:06Z

[Term]
id: GO:0035563
name: positive regulation of chromatin binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding
is_a: GO:0051099 ! positive regulation of binding
created_by: bf
creation_date: 2010-05-19T10:29:41Z

[Term]
id: GO:0035624
name: receptor transactivation
namespace: biological_process
def: "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer." [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387]
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: positively_regulates GO:0060089 ! molecular transducer activity
relationship: regulates GO:0050794 ! regulation of cellular process
relationship: regulates GO:0060089 ! molecular transducer activity
created_by: bf
creation_date: 2010-12-08T04:18:18Z

[Term]
id: GO:0035743
name: CD4-positive, alpha-beta T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002369 ! T cell cytokine production
created_by: bf
creation_date: 2011-03-17T02:21:51Z

[Term]
id: GO:0035744
name: T-helper 1 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "Th1 cell cytokine production" EXACT [CL:0000545]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
created_by: bf
creation_date: 2011-03-17T02:22:54Z

[Term]
id: GO:0035745
name: T-helper 2 cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "Th2 cell cytokine production" EXACT [CL:0000546]
is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production
created_by: bf
creation_date: 2011-03-17T02:23:32Z

[Term]
id: GO:0035746
name: granzyme A production
namespace: biological_process
def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: bf
creation_date: 2011-03-17T02:39:11Z

[Term]
id: GO:0035944
name: perforin production
namespace: biological_process
def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: bf
creation_date: 2011-07-27T11:44:21Z

[Term]
id: GO:0036262
name: granulysin production
namespace: biological_process
def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: bf
creation_date: 2012-06-18T02:11:15Z

[Term]
id: GO:0036270
name: response to diuretic
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
created_by: bf
creation_date: 2012-07-09T01:26:24Z

[Term]
id: GO:0036271
name: response to methylphenidate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [GOC:hp, Wikipedia:Methylphenidate]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to MPD" EXACT [CHEBI:6887]
synonym: "response to MPH" EXACT [CHEBI:6887]
synonym: "response to ritalin" EXACT [CHEBI:6887]
is_a: GO:0042221 ! response to chemical
created_by: bf
creation_date: 2012-07-09T01:30:57Z

[Term]
id: GO:0036272
name: response to gemcitabine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [GOC:hp, Wikipedia:Gemcitabine]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901]
synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T01:36:03Z

[Term]
id: GO:0036273
name: response to statin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664]
synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664]
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T01:54:01Z

[Term]
id: GO:0036274
name: response to lapatinib
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T02:02:26Z

[Term]
id: GO:0036275
name: response to 5-fluorouracil
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345]
synonym: "response to fluorouracil" EXACT [GOC:hp]
is_a: GO:0042221 ! response to chemical
created_by: bf
creation_date: 2012-07-09T02:08:23Z

[Term]
id: GO:0036276
name: response to antidepressant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
created_by: bf
creation_date: 2012-07-09T02:12:44Z

[Term]
id: GO:0036277
name: response to anticonvulsant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
created_by: bf
creation_date: 2012-07-09T02:40:12Z

[Term]
id: GO:0036287
name: response to iloperidone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-16T05:01:29Z

[Term]
id: GO:0036288
name: response to ximelagatran
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-16T05:03:56Z

[Term]
id: GO:0036301
name: macrophage colony-stimulating factor production
namespace: biological_process
def: "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk]
subset: gocheck_do_not_annotate
synonym: "M-CSF production" EXACT [GOC:vk]
is_a: GO:0001816 ! cytokine production
created_by: bf
creation_date: 2012-08-07T14:07:13Z

[Term]
id: GO:0036392
name: chemokine (C-C motif) ligand 20 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 20 production" EXACT []
synonym: "CCL-20 production" EXACT []
synonym: "CCL20 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: bf
creation_date: 2013-06-17T14:42:07Z

[Term]
id: GO:0038183
name: bile acid signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:12016314, PMID:36409000]
comment: This term is not for direct annotation. Please use a more specific child: 'cell surface bile acid receptor signaling pathway' for GPCRs and 'intracellular bile acid receptor signaling pathway' for nuclear receptors.
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
is_a: GO:0050794 ! regulation of cellular process
relationship: part_of GO:0050789 ! regulation of biological process
relationship: part_of GO:0051716 ! cellular response to stimulus
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26958" xsd:anyURI
created_by: bf
creation_date: 2013-05-16T10:35:10Z

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0042221
name: response to chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0042637
name: catagen
namespace: biological_process
def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair regression" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0042638
name: exogen
namespace: biological_process
def: "The shedding phase of the hair cycle." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair shedding" NARROW []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0042639
name: telogen
namespace: biological_process
def: "The resting phase of hair cycle." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair resting phase" NARROW []
is_a: GO:0044851 ! hair cycle phase

[Term]
id: GO:0042640
name: anagen
namespace: biological_process
def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "hair growth" RELATED []
is_a: GO:0044851 ! hair cycle phase
relationship: part_of GO:0032501 ! multicellular organismal process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0042696
name: menarche
namespace: biological_process
def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menarche
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042697
name: menopause
namespace: biological_process
def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menopause
is_a: GO:0022601 ! menstrual cycle phase
is_a: GO:1990636 ! reproductive senescence

[Term]
id: GO:0042703
name: menstruation
namespace: biological_process
def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Menstruation
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
is_a: GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17727" xsd:anyURI

[Term]
id: GO:0043087
name: regulation of GTPase activity
namespace: biological_process
alt_id: GO:0032312
alt_id: GO:0032313
alt_id: GO:0032314
alt_id: GO:0032315
alt_id: GO:0032316
alt_id: GO:0032317
alt_id: GO:0032318
alt_id: GO:0032319
alt_id: GO:0043088
def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of ARF GTPase activity" NARROW []
synonym: "regulation of Cdc42 GTPase activity" NARROW []
synonym: "regulation of Rab GTPase activity" NARROW []
synonym: "regulation of Rac GTPase activity" NARROW []
synonym: "regulation of Ral GTPase activity" NARROW []
synonym: "regulation of Ran GTPase activity" NARROW []
synonym: "regulation of Rap GTPase activity" NARROW []
synonym: "regulation of Ras GTPase activity" NARROW []
synonym: "regulation of Rho GTPase activity" NARROW []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "atom binding" RELATED []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
alt_id: GO:0043283
alt_id: GO:0044259
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
synonym: "multicellular organismal macromolecule metabolic process" NARROW []
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0110165 ! cellular anatomical structure
relationship: has_part GO:0110165 ! cellular anatomical structure
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI

[Term]
id: GO:0043228
name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_mouse
synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0110165 ! cellular anatomical structure
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21881" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_pir
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005622 ! intracellular anatomical structure
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28153" xsd:anyURI

[Term]
id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "activation of DNA binding" NARROW []
synonym: "stimulation of DNA binding" NARROW []
synonym: "up regulation of DNA binding" EXACT []
synonym: "up-regulation of DNA binding" EXACT []
synonym: "upregulation of DNA binding" EXACT []
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "down regulation of DNA binding" EXACT []
synonym: "down-regulation of DNA binding" EXACT []
synonym: "downregulation of DNA binding" EXACT []
synonym: "inhibition of DNA binding" NARROW []
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043393
name: regulation of protein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0043603
name: amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "amide metabolism" EXACT []
synonym: "cellular amide metabolic process" EXACT []
is_a: GO:0008152 ! metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI

[Term]
id: GO:0043711
name: pilus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl]
comment: Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction.
subset: gocheck_do_not_annotate
synonym: "pilus organisation" EXACT [GOC:mah]
synonym: "pilus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
alt_id: GO:0071843
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular component biogenesis at cellular level" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_do_not_annotate
is_a: GO:0065007 ! biological regulation
created_by: jl
creation_date: 2009-04-21T04:07:27Z

[Term]
id: GO:0044094
name: host cell nuclear part
namespace: cellular_component
def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0033646 ! host intracellular part
created_by: jl
creation_date: 2009-04-22T01:59:14Z

[Term]
id: GO:0044217
name: other organism part
namespace: cellular_component
def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure
created_by: jl
creation_date: 2009-11-12T01:18:21Z

[Term]
id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "primary metabolism" EXACT []
xref: Wikipedia:Primary_metabolite
is_a: GO:0008152 ! metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0044249
name: cellular biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
synonym: "cellular anabolism" EXACT []
synonym: "cellular biosynthesis" EXACT []
synonym: "cellular formation" EXACT []
synonym: "cellular synthesis" EXACT []
is_a: GO:0008152 ! metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27052" xsd:anyURI

[Term]
id: GO:0044362
name: negative regulation of molecular function in another organism
namespace: biological_process
def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]
subset: gocheck_do_not_annotate
synonym: "negative regulation of molecular function in other organism" EXACT []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms
created_by: jl
creation_date: 2011-10-27T02:12:49Z

[Term]
id: GO:0044419
name: biological process involved in interspecies interaction between organisms
namespace: biological_process
def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction between organisms" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI

[Term]
id: GO:0044467
name: glial cell-derived neurotrophic factor production
namespace: biological_process
def: "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307]
subset: gocheck_do_not_annotate
synonym: "GDNF production" EXACT []
synonym: "glial cell line-derived neurotrophic factor production" RELATED []
synonym: "glial cell-derived neurotrophic factor secretion" NARROW []
is_a: GO:0001816 ! cytokine production
created_by: jl
creation_date: 2012-01-17T04:26:05Z

[Term]
id: GO:0044807
name: macrophage migration inhibitory factor production
namespace: biological_process
def: "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "MIF production" EXACT []
is_a: GO:0001816 ! cytokine production
created_by: jl
creation_date: 2013-09-11T12:04:09Z

[Term]
id: GO:0044808
name: oncostatin M production
namespace: biological_process
def: "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "OSM production" EXACT []
is_a: GO:0001816 ! cytokine production
created_by: jl
creation_date: 2013-09-11T12:18:00Z

[Term]
id: GO:0044809
name: chemokine (C-C motif) ligand 17 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL17 production" EXACT []
synonym: "TARC production" EXACT []
synonym: "thymus and activation regulated chemokine production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: jl
creation_date: 2013-09-11T12:21:31Z

[Term]
id: GO:0044838
name: cell quiescence
namespace: biological_process
def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah]
comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "cellular quiescence" EXACT [GOC:mah]
synonym: "G0 phase" RELATED [GOC:mah]
synonym: "quiescence" BROAD [GOC:mah]
is_a: GO:0022403 ! cell cycle phase
created_by: jl
creation_date: 2014-02-26T16:15:51Z

[Term]
id: GO:0044844
name: meiotic interphase II
namespace: biological_process
def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051328 ! meiotic interphase
is_a: GO:0098765 ! meiosis II cell cycle phase
created_by: jl
creation_date: 2014-03-26T16:52:27Z

[Term]
id: GO:0044848
name: biological phase
namespace: biological_process
def: "A distinct period or stage in a biological process or cycle." [GOC:jl]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_annotate
disjoint_from: GO:0050896 ! response to stimulus
disjoint_from: GO:0051179 ! localization
disjoint_from: GO:0071840 ! cellular component organization or biogenesis
created_by: jl
creation_date: 2014-07-16T13:12:40Z

[Term]
id: GO:0044851
name: hair cycle phase
namespace: biological_process
def: "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase
created_by: jl
creation_date: 2014-07-16T14:22:09Z

[Term]
id: GO:0045239
name: tricarboxylic acid cycle heteromeric enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "TCA cycle enzyme complex" EXACT []
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
alt_id: GO:0043119
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
alt_id: GO:0043118
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
alt_id: GO:0051242
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009987 ! cellular process
relationship: positively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
alt_id: GO:0051243
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009987 ! cellular process
relationship: negatively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050896 ! response to stimulus
relationship: regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050896 ! response to stimulus
relationship: positively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050896 ! response to stimulus
relationship: negatively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
subset: gocheck_do_not_annotate
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
relationship: part_of GO:0009987 ! cellular process
relationship: part_of GO:0048856 ! anatomical structure development
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
synonym: "organismal reproductive process" BROAD []
synonym: "reproductive process in a multicellular organism" EXACT []
is_a: GO:0022414 ! reproductive process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27054" xsd:anyURI

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "development of an anatomical structure" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009987 ! cellular process
relationship: regulates GO:0009987 ! cellular process

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "physiological response to stimulus" EXACT []

[Term]
id: GO:0051098
name: regulation of binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "activation of binding" NARROW []
synonym: "stimulation of binding" NARROW []
synonym: "up regulation of binding" EXACT []
synonym: "up-regulation of binding" EXACT []
synonym: "upregulation of binding" EXACT []
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "down regulation of binding" EXACT []
synonym: "down-regulation of binding" EXACT []
synonym: "downregulation of binding" EXACT []
synonym: "inhibition of binding" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051179
name: localization
namespace: biological_process
alt_id: GO:1902578
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
synonym: "single organism localization" RELATED [GOC:TermGenie]
synonym: "single-organism localization" RELATED []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27052" xsd:anyURI
created_by: jl
creation_date: 2013-12-18T13:51:04Z

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI

[Term]
id: GO:0051318
name: G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G1_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051319
name: G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:G2_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051320
name: S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "S-phase" EXACT []
xref: Wikipedia:S_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051322
name: anaphase
namespace: biological_process
def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Anaphase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051323
name: metaphase
namespace: biological_process
def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Metaphase
is_a: GO:0098762 ! meiotic cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051324
name: prophase
namespace: biological_process
def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Prophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051325
name: interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "karyostasis" EXACT []
synonym: "resting phase" BROAD []
xref: Wikipedia:Interphase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0051326
name: telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Telophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051327
name: meiotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of meiotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0051328
name: meiotic interphase
namespace: biological_process
def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of meiotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0051329
name: mitotic interphase
namespace: biological_process
def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "interphase of mitotic cell cycle" EXACT []
is_a: GO:0051325 ! interphase
is_a: GO:0098763 ! mitotic cell cycle phase

[Term]
id: GO:0051330
name: meiotic G1 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G1 phase of meiotic cell cycle" EXACT []
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051331
name: meiotic G2 phase
namespace: biological_process
def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "G2 phase of meiotic cell cycle" EXACT []
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051332
name: meiotic S phase
namespace: biological_process
def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "premeiotic S-phase" EXACT []
synonym: "S phase of meiotic cell cycle" EXACT []
synonym: "S-phase of meiotic cell cycle" EXACT []
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051328 ! meiotic interphase

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
alt_id: GO:1902580
def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
synonym: "single organism cellular localization" EXACT [GOC:TermGenie]
synonym: "single-organism cellular localization" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI
created_by: jl
creation_date: 2013-12-18T14:04:32Z

[Term]
id: GO:0051703
name: biological process involved in intraspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "intraspecies interaction between organisms" EXACT []
synonym: "intraspecies interaction with other organisms" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt]
subset: gocheck_do_not_annotate
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote

[Term]
id: GO:0060206
name: estrous cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0060207
name: diestrus
namespace: biological_process
def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060208
name: proestrus
namespace: biological_process
def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060209
name: estrus
namespace: biological_process
def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "oestrus" EXACT []
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060210
name: metestrus
namespace: biological_process
def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060380
name: regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:1904742 ! regulation of telomeric DNA binding

[Term]
id: GO:0060381
name: positive regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding
is_a: GO:1904744 ! positive regulation of telomeric DNA binding

[Term]
id: GO:0061082
name: myeloid leukocyte cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
created_by: dph
creation_date: 2010-04-13T11:29:42Z

[Term]
id: GO:0061919
name: process utilizing autophagic mechanism
namespace: biological_process
def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
created_by: dph
creation_date: 2017-07-13T19:42:14Z

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "regulation" BROAD []

[Term]
id: GO:0070603
name: SWI/SNF superfamily-type complex
namespace: cellular_component
alt_id: GO:0090544
def: "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]
subset: gocheck_do_not_annotate
synonym: "BAF-type complex" EXACT []
synonym: "SWI-SNF global transcription activator complex" RELATED [CORUM:224]
synonym: "SWI-SNF-type complex" EXACT [GOC:mah]
synonym: "SWI/SNF-type complex" RELATED [GOC:krc]
synonym: "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex" RELATED [GOC:krc]
is_a: GO:0140513 ! nuclear protein-containing complex
relationship: part_of GO:0043228 ! non-membrane-bounded organelle
created_by: mah
creation_date: 2009-04-29T12:55:46Z

[Term]
id: GO:0070753
name: interleukin-35 production
namespace: biological_process
alt_id: GO:0070749
alt_id: GO:0072626
def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "IL-35 production" EXACT [GOC:add]
synonym: "interleukin-35 biosynthetic process" NARROW []
synonym: "interleukin-35 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
created_by: mah
creation_date: 2009-06-23T01:25:11Z

[Term]
id: GO:0070887
name: cellular response to chemical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
is_a: GO:0051716 ! cellular response to stimulus
created_by: mah
creation_date: 2009-08-27T04:41:45Z

[Term]
id: GO:0070918
name: regulatory ncRNA processing
namespace: biological_process
alt_id: GO:0031051
def: "A process leading to the generation of a functional regulatory non-coding RNA." [GOC:mah, PMID:15196465, PMID:19239886]
subset: gocheck_do_not_annotate
synonym: "gene silencing by RNA, production of guide RNA" NARROW [GOC:mah]
synonym: "gene silencing by RNA, production of small RNA" NARROW [GOC:mah]
synonym: "primary sncRNA processing" NARROW []
synonym: "production of small RNA involved in gene silencing by RNA" NARROW []
synonym: "small regulatory ncRNA maturation" NARROW []
synonym: "small regulatory ncRNA processing" NARROW []
synonym: "sncRNA processing" NARROW []
synonym: "sncRNA production" NARROW []
is_a: GO:0044238 ! primary metabolic process
relationship: part_of GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: part_of GO:0032774 ! RNA biosynthetic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19303" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23081" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24199" xsd:anyURI
created_by: mah
creation_date: 2009-09-11T03:32:19Z

[Term]
id: GO:0070930
name: trans-translation-dependent protein tagging
namespace: biological_process
def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:jsg, GOC:mah]
comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus.
subset: gocheck_do_not_annotate
synonym: "co-translational protein tagging" EXACT [GOC:jh2, GOC:jsg]
synonym: "cotranslational protein tagging" EXACT [GOC:mah]
synonym: "protein modification by trans-translation" EXACT [GOC:mah]
is_a: GO:0019538 ! protein metabolic process
relationship: has_part GO:0009059 ! macromolecule biosynthetic process
created_by: mah
creation_date: 2009-09-16T04:10:49Z

[Term]
id: GO:0071173
name: spindle assembly checkpoint signaling
namespace: biological_process
alt_id: GO:0072486
def: "A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).
subset: gocheck_do_not_annotate
synonym: "SAC" BROAD [GOC:mah]
synonym: "signal transduction involved in spindle assembly checkpoint" EXACT []
synonym: "spindle assembly checkpoint" EXACT []
is_a: GO:0031577 ! spindle checkpoint signaling
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20935" xsd:anyURI
created_by: mah
creation_date: 2009-11-23T12:36:57Z

[Term]
id: GO:0071174
name: mitotic spindle checkpoint signaling
namespace: biological_process
alt_id: GO:0072477
def: "A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints).
subset: gocheck_do_not_annotate
synonym: "mitotic cell cycle spindle checkpoint" EXACT []
synonym: "mitotic spindle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic cell cycle spindle checkpoint" EXACT []
synonym: "signal transduction involved in mitotic spindle checkpoint" EXACT []
synonym: "topo II checkpoint" RELATED []
synonym: "topoisomerase II checkpoint" RELATED []
is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling
is_a: GO:0031577 ! spindle checkpoint signaling
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20935" xsd:anyURI
created_by: mah
creation_date: 2009-11-23T12:41:36Z

[Term]
id: GO:0071214
name: cellular response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to abiotic stress" NARROW [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051716 ! cellular response to stimulus
created_by: mah
creation_date: 2009-12-03T01:02:11Z

[Term]
id: GO:0071216
name: cellular response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to biotic stress" NARROW [GOC:mah]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051716 ! cellular response to stimulus
created_by: mah
creation_date: 2009-12-03T01:09:08Z

[Term]
id: GO:0071229
name: cellular response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "cellular response to acid" BROAD []
synonym: "cellular response to acid anion" RELATED []
synonym: "cellular response to oxoanion" RELATED []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: mah
creation_date: 2009-12-03T02:07:23Z

[Term]
id: GO:0071411
name: cellular response to fluoxetine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah, GOC:pr]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0014076 ! response to fluoxetine
is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: mah
creation_date: 2009-12-14T03:09:58Z

[Term]
id: GO:0071495
name: cellular response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009719 ! response to endogenous stimulus
created_by: mah
creation_date: 2009-12-18T02:25:40Z

[Term]
id: GO:0071496
name: cellular response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0009605 ! response to external stimulus
created_by: mah
creation_date: 2009-12-18T02:36:52Z

[Term]
id: GO:0071605
name: monocyte chemotactic protein-1 production
namespace: biological_process
def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL2 production" EXACT [GOC:add, GOC:rv]
synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:09:53Z

[Term]
id: GO:0071606
name: chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL4 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:16:42Z

[Term]
id: GO:0071607
name: macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL9 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv]
synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:19:52Z

[Term]
id: GO:0071608
name: macrophage inflammatory protein-1 alpha production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL3 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:24:17Z

[Term]
id: GO:0071609
name: chemokine (C-C motif) ligand 5 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL5 production" EXACT [GOC:add, GOC:rv]
synonym: "RANTES production" EXACT [GOC:bf]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:32:35Z

[Term]
id: GO:0071610
name: chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL1 production" EXACT [GOC:add, GOC:rv]
synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv]
synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:35:00Z

[Term]
id: GO:0071611
name: granulocyte colony-stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add]
synonym: "CSF3 production" EXACT [GOC:add]
synonym: "filgrastim production" EXACT [GOC:add]
synonym: "G-CSF production" EXACT [GOC:add]
synonym: "granulocyte colony stimulating factor production" EXACT []
synonym: "lenograstim production" EXACT [GOC:add]
synonym: "pluripoietin production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production
created_by: mah
creation_date: 2010-02-05T04:38:11Z

[Term]
id: GO:0071612
name: IP-10 production
namespace: biological_process
def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
subset: gocheck_do_not_annotate
synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv]
synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-02-05T04:43:56Z

[Term]
id: GO:0071613
name: granzyme B production
namespace: biological_process
def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: mah
creation_date: 2010-02-05T04:47:15Z

[Term]
id: GO:0071706
name: tumor necrosis factor superfamily cytokine production
namespace: biological_process
def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "TNF superfamily production" RELATED [GOC:rv]
synonym: "TNFSF cytokine production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production
created_by: mah
creation_date: 2010-03-09T02:40:35Z

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
namespace: biological_process
alt_id: GO:0071841
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular component organization or biogenesis at cellular level" EXACT []
is_a: GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27189" xsd:anyURI
created_by: mah
creation_date: 2010-09-10T01:39:16Z

[Term]
id: GO:0071924
name: chemokine (C-C motif) ligand 22 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah]
synonym: "CCL-22 production" EXACT [GOC:mah]
synonym: "CCL22 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-09-28T11:33:13Z

[Term]
id: GO:0071925
name: thymic stromal lymphopoietin production
namespace: biological_process
def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180]
subset: gocheck_do_not_annotate
synonym: "TSLP production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-09-28T11:38:55Z

[Term]
id: GO:0071954
name: chemokine (C-C motif) ligand 11 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9600955]
subset: gocheck_do_not_annotate
synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah]
synonym: "CCL-11 production" EXACT [GOC:mah]
synonym: "CCL11 production" EXACT [GOC:mah]
synonym: "eotaxin production" BROAD [GOC:mah]
synonym: "eotaxin-1 production" EXACT [GOC:mah]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2010-10-08T12:10:34Z

[Term]
id: GO:0072001
name: renal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:6996269]
subset: gocheck_do_not_annotate
synonym: "urinary system development" BROAD [GOC:yaf]
synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development
created_by: mah
creation_date: 2010-01-25T10:31:00Z

[Term]
id: GO:0072048
name: renal system pattern specification
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10]
subset: gocheck_do_not_annotate
synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0072001 ! renal system development
created_by: mah
creation_date: 2010-01-25T03:31:51Z

[Term]
id: GO:0072337
name: modified amino acid transport
namespace: biological_process
def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "amino acid derivative transport" EXACT []
is_a: GO:0006810 ! transport
created_by: mah
creation_date: 2010-11-04T12:18:23Z

[Term]
id: GO:0072535
name: tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "RANKL production" EXACT [GOC:ebc, PR:000002107]
synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107]
synonym: "tumor necrosis factor ligand superfamily member 11 production" EXACT [GOC:bf, PR:000002107]
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production
created_by: mah
creation_date: 2011-01-14T01:42:23Z

[Term]
id: GO:0072566
name: chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CXCL1 production" EXACT [GOC:BHF]
synonym: "KC production" EXACT [GOC:BHF]
synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF]
synonym: "SCYB1 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2011-01-31T11:31:58Z

[Term]
id: GO:0072567
name: chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah]
subset: gocheck_do_not_annotate
synonym: "CXCL2 production" EXACT [GOC:mah]
synonym: "MIP-2 production" EXACT [GOC:BHF]
synonym: "MIP2 production" EXACT [GOC:BHF]
synonym: "SCYB2 production" EXACT [GOC:BHF]
is_a: GO:0032602 ! chemokine production
created_by: mah
creation_date: 2011-01-31T11:33:40Z

[Term]
id: GO:0072627
name: interleukin-28A production
namespace: biological_process
alt_id: GO:0072628
def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-28A production" EXACT [GOC:BHF]
synonym: "IL28A production" EXACT [GOC:BHF]
synonym: "interferon lambda 2 production" EXACT [GOC:BHF]
synonym: "interleukin-28A secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072629
name: interleukin-28B production
namespace: biological_process
alt_id: GO:0072630
def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-28B production" EXACT [GOC:BHF]
synonym: "IL28B production" EXACT [GOC:BHF]
synonym: "interferon lambda 3 production" EXACT [GOC:BHF]
synonym: "interleukin-28B secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072631
name: interleukin-29 production
namespace: biological_process
alt_id: GO:0072632
def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IL-29 production" EXACT [GOC:BHF]
synonym: "IL29 production" EXACT [GOC:BHF]
synonym: "interferon lambda 1 production" EXACT [GOC:BHF]
synonym: "interleukin-29 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072633
name: interleukin-30 production
namespace: biological_process
alt_id: GO:0072634
def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:30328794]
subset: gocheck_do_not_annotate
synonym: "IL-30 production" EXACT [GOC:BHF]
synonym: "interleukin-30 complex production" EXACT [GOC:BHF]
synonym: "interleukin-30 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072635
name: interleukin-31 production
namespace: biological_process
alt_id: GO:0072636
def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:30328794]
subset: gocheck_do_not_annotate
synonym: "IL-31 production" EXACT [GOC:BHF]
synonym: "interleukin-31 secretion" NARROW []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072637
name: interleukin-32 production
namespace: biological_process
alt_id: GO:0072638
alt_id: GO:0150188
def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:23729669]
subset: gocheck_do_not_annotate
synonym: "IL-32 production" EXACT [GOC:BHF]
synonym: "IL32 production" EXACT [GOC:BHF]
synonym: "interleukin-32 biosynthetic process" NARROW []
synonym: "interleukin-32 secretion" NARROW []
synonym: "NK4 production" NARROW [GOC:BHF]
synonym: "TAIF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
created_by: bc
creation_date: 2020-02-21T10:26:40Z

[Term]
id: GO:0072639
name: interleukin-33 production
namespace: biological_process
alt_id: GO:0072640
alt_id: GO:0150126
def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:29778524]
subset: gocheck_do_not_annotate
synonym: "C9orf26 production" NARROW [GOC:BHF]
synonym: "IL-33 production" EXACT [GOC:BHF]
synonym: "IL1F11 production" NARROW [GOC:BHF]
synonym: "IL33 production" EXACT [GOC:BHF]
synonym: "interleukin-33 biosynthetic process" NARROW []
synonym: "interleukin-33 secretion" NARROW []
synonym: "NF-HEV production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0072645
name: interferon-delta production
namespace: biological_process
alt_id: GO:0072646
def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-delta production" EXACT [GOC:mah]
synonym: "IFND production" EXACT [GOC:BHF]
synonym: "interferon-delta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072647
name: interferon-epsilon production
namespace: biological_process
alt_id: GO:0072648
def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-epsilon production" EXACT [GOC:mah]
synonym: "IFNE production" EXACT [GOC:BHF]
synonym: "interferon-epsilon secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072649
name: interferon-kappa production
namespace: biological_process
alt_id: GO:0072650
def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-kappa production" EXACT [GOC:mah]
synonym: "IFNK production" EXACT [GOC:BHF]
synonym: "interferon-kappa secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072651
name: interferon-tau production
namespace: biological_process
alt_id: GO:0072652
def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-tau production" EXACT [GOC:mah]
synonym: "IFN-tau secretion" EXACT [GOC:mah]
synonym: "IFNT production" EXACT [GOC:BHF]
synonym: "interferon-tau secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072653
name: interferon-omega production
namespace: biological_process
alt_id: GO:0072654
def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "IFN-omega production" EXACT [GOC:mah]
synonym: "IFNW production" EXACT [GOC:BHF]
synonym: "interferon-omega secretion" NARROW []
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0072690
name: single-celled organism vegetative growth phase
namespace: biological_process
alt_id: GO:0062178
def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "stationary phase" NARROW []
synonym: "vegetative growth of a single-celled organism" EXACT []
is_a: GO:0044848 ! biological phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18275" xsd:anyURI
created_by: mah
creation_date: 2011-08-19T12:05:19Z

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
created_by: dhl
creation_date: 2009-05-06T04:51:28Z

[Term]
id: GO:0090231
name: regulation of spindle checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
is_a: GO:1901976 ! regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031577 ! spindle checkpoint signaling
relationship: regulates GO:0031577 ! spindle checkpoint signaling
created_by: tb
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090232
name: positive regulation of spindle checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0090231 ! regulation of spindle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031577 ! spindle checkpoint signaling
relationship: positively_regulates GO:0031577 ! spindle checkpoint signaling
created_by: tb
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090233
name: negative regulation of spindle checkpoint
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090231 ! regulation of spindle checkpoint
is_a: GO:1901977 ! negative regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031577 ! spindle checkpoint signaling
relationship: negatively_regulates GO:0031577 ! spindle checkpoint signaling
created_by: tb
creation_date: 2010-01-20T10:29:43Z

[Term]
id: GO:0090269
name: fibroblast growth factor production
namespace: biological_process
def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production
created_by: tb
creation_date: 2010-02-05T02:33:33Z

[Term]
id: GO:0090304
name: nucleic acid metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26133" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27052" xsd:anyURI
created_by: tb
creation_date: 2010-04-07T10:18:47Z

[Term]
id: GO:0090323
name: prostaglandin secretion involved in immune response
namespace: biological_process
def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0009987 ! cellular process
relationship: part_of GO:0050789 ! regulation of biological process
relationship: part_of GO:0050896 ! response to stimulus
relationship: part_of GO:0051179 ! localization
created_by: tb
creation_date: 2010-05-12T10:41:04Z

[Term]
id: GO:0090360
name: platelet-derived growth factor production
namespace: biological_process
def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production
created_by: tb
creation_date: 2010-07-12T10:32:27Z

[Term]
id: GO:0097087
name: interleukin-17A production
namespace: biological_process
alt_id: GO:0150154
def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PMID:27901018]
subset: gocheck_do_not_annotate
synonym: "IL-17A production" EXACT []
synonym: "interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032620 ! interleukin-17 production
created_by: bc
creation_date: 2011-06-23T11:31:10Z

[Term]
id: GO:0097088
name: interleukin-17F production
namespace: biological_process
def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, Wikipedia:Interleukin_17]
subset: gocheck_do_not_annotate
synonym: "IL-17F production" EXACT []
is_a: GO:0032620 ! interleukin-17 production
created_by: pr
creation_date: 2011-06-23T11:32:59Z

[Term]
id: GO:0097366
name: response to bronchodilator
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to bronchodilator agent" EXACT []
synonym: "response to broncholytic agent" RELATED []
is_a: GO:0042221 ! response to chemical
created_by: pr
creation_date: 2012-08-01T16:13:31Z

[Term]
id: GO:0097388
name: chemokine (C-C motif) ligand 19 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL19 production" EXACT []
synonym: "EBI1 ligand chemokine production" EXACT []
synonym: "ELC production" EXACT []
synonym: "macrophage inflammatory protein-3-beta production" EXACT []
synonym: "MIP-3-beta production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: pr
creation_date: 2012-10-23T07:54:10Z

[Term]
id: GO:0097389
name: chemokine (C-C motif) ligand 21 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CCL21 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: pr
creation_date: 2012-10-23T07:56:26Z

[Term]
id: GO:0097390
name: chemokine (C-X-C motif) ligand 12 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL12 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: pr
creation_date: 2012-10-23T07:57:28Z

[Term]
id: GO:0097391
name: chemokine (C-X-C motif) ligand 13 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL13 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: pr
creation_date: 2012-10-23T07:58:28Z

[Term]
id: GO:0097392
name: chemokine (C-X-C motif) ligand 16 production
namespace: biological_process
def: "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
subset: gocheck_do_not_annotate
synonym: "CXCL16 production" EXACT []
is_a: GO:0032602 ! chemokine production
created_by: pr
creation_date: 2012-10-23T07:59:43Z

[Term]
id: GO:0097722
name: sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc]
subset: gocheck_do_not_annotate
synonym: "sperm movement" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0022414 ! reproductive process
created_by: pr
creation_date: 2016-09-01T12:00:45Z

[Term]
id: GO:0098590
name: plasma membrane region
namespace: cellular_component
def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_annotate
synonym: "region of plasma membrane" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0110165 ! cellular anatomical structure
created_by: dos
creation_date: 2014-03-06T11:55:32Z

[Term]
id: GO:0098751
name: bone cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0009987 ! cellular process

[Term]
id: GO:0098762
name: meiotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase
relationship: happens_during GO:0007049 ! cell cycle
relationship: happens_during GO:0022414 ! reproductive process

[Term]
id: GO:0098763
name: mitotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase
relationship: happens_during GO:0007049 ! cell cycle

[Term]
id: GO:0098764
name: meiosis I cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098765
name: meiosis II cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098768
name: meiotic prometaphase I
namespace: biological_process
def: "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate." [PMID:16012859]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098764 ! meiosis I cell cycle phase
relationship: part_of GO:0051327 ! meiotic M phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24374" xsd:anyURI

[Term]
id: GO:0098772
name: molecular function regulator activity
namespace: molecular_function
def: "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "molecular function regulator" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20854" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20862" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25165" xsd:anyURI

[Term]
id: GO:0098798
name: mitochondrial protein-containing complex
namespace: cellular_component
def: "A protein complex that is part of a mitochondrion." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "mitochondrial protein complex" RELATED []
relationship: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0098802
name: plasma membrane signaling receptor complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
relationship: part_of GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0099134
name: chimeric sorocarp development
namespace: biological_process
def: "Development of a sorocarp formed by aggregation of cells with different genotypes." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0099136 ! chimeric non-reproductive fruiting body development

[Term]
id: GO:0099135
name: chimeric colonial development
namespace: biological_process
def: "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms

[Term]
id: GO:0099136
name: chimeric non-reproductive fruiting body development
namespace: biological_process
def: "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes." [PMID:18272966]
subset: gocheck_do_not_annotate
is_a: GO:0099135 ! chimeric colonial development

[Term]
id: GO:0099522
name: cytosolic region
namespace: cellular_component
def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "region of cytosol" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0099568
name: cytoplasmic region
namespace: cellular_component
def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos]
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0099738
name: cell cortex region
namespace: cellular_component
def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "perimembrane region" EXACT []
is_a: GO:0099568 ! cytoplasmic region

[Term]
id: GO:0110100
name: spindle pole body separation
namespace: biological_process
def: "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble." [GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0006996 ! organelle organization
relationship: part_of GO:0022402 ! cell cycle process
created_by: kmv
creation_date: 2018-03-06T15:09:28Z

[Term]
id: GO:0110165
name: cellular anatomical structure
namespace: cellular_component
def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular anatomical entity" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28978" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z

[Term]
id: GO:0140029
name: exocytic process
namespace: biological_process
def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0006810 ! transport
relationship: part_of GO:0009987 ! cellular process
created_by: pg
creation_date: 2017-05-15T13:20:45Z

[Term]
id: GO:0140104
name: molecular carrier activity
namespace: molecular_function
def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]
comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization.
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: Reactome:R-HSA-3149494 "MMACHC:cob(II)alamin binds MMADHC"
xref: Reactome:R-HSA-3149563 "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria"
xref: Reactome:R-HSA-3159259 "MMAA:MUT binds AdoCbl"
xref: Reactome:R-HSA-3204318 "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR"
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14221" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20848" xsd:anyURI
created_by: pg
creation_date: 2017-09-19T13:10:18Z

[Term]
id: GO:0140110
name: transcription regulator activity
namespace: molecular_function
def: "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/13588" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23609" xsd:anyURI
created_by: pg
creation_date: 2017-10-18T07:05:44Z

[Term]
id: GO:0140142
name: nucleocytoplasmic carrier activity
namespace: molecular_function
alt_id: GO:0061717
alt_id: GO:0090631
def: "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "miRNA transporter activity" NARROW []
synonym: "nucleocytoplasmic importin/exportin activity" EXACT []
synonym: "pre-miRNA transporter activity" NARROW []
is_a: GO:0140104 ! molecular carrier activity
relationship: part_of GO:0006810 ! transport
relationship: part_of GO:0051641 ! cellular localization
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14336" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/17399" xsd:anyURI
created_by: pg
creation_date: 2017-12-06T13:40:40Z

[Term]
id: GO:0140513
name: nuclear protein-containing complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "nuclear complex" EXACT []
relationship: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043229 ! intracellular organelle
created_by: pg
creation_date: 2020-09-09T05:12:38Z

[Term]
id: GO:0140657
name: ATP-dependent activity
namespace: molecular_function
def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "ATP hydrolysis-dependent activity" EXACT []
synonym: "ATPase activity" EXACT []
synonym: "ATPase activity, coupled" EXACT []
synonym: "ATPase-dependent activity" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI
created_by: pg
creation_date: 2021-06-15T07:35:06Z

[Term]
id: GO:0140699
name: cyclic GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [PMID:23258413]
comment: Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that describes the position of the phosphate group on the cGAMP molecule.
subset: gocheck_do_not_annotate
synonym: "cyclic-GMP-AMP synthase activity" EXACT []
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21980" xsd:anyURI
created_by: pg
creation_date: 2021-08-27T05:05:37Z

[Term]
id: GO:0140702
name: cyclic GMP-AMP binding
namespace: molecular_function
def: "Binding to cyclic GMP-AMP (cGAMP) nucleotide." [PMID:23258412]
subset: gocheck_do_not_annotate
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21980" xsd:anyURI
created_by: pg
creation_date: 2021-08-27T05:39:31Z

[Term]
id: GO:0140730
name: amphiregulin production
namespace: biological_process
def: "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." [PMID:24463227]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "AREG production" BROAD []
is_a: GO:0001816 ! cytokine production
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21878" xsd:anyURI
created_by: pg
creation_date: 2021-11-24T07:09:44Z

[Term]
id: GO:0140779
name: XCL1 production
namespace: biological_process
def: "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:7973732]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "lymphotactin production" EXACT []
xref: Wikipedia:XCL1
is_a: GO:0001816 ! cytokine production
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23071" xsd:anyURI
created_by: pg
creation_date: 2022-03-24T07:11:34Z

[Term]
id: GO:0141187
name: nucleic acid biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0090304 ! nucleic acid metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27408" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27633" xsd:anyURI
created_by: pg
creation_date: 2024-03-25T07:33:40Z

[Term]
id: GO:0141188
name: nucleic acid catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0090304 ! nucleic acid metabolic process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27408" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27633" xsd:anyURI
created_by: pg
creation_date: 2024-03-25T07:35:06Z

[Term]
id: GO:0150137
name: interleukin-37 production
namespace: biological_process
def: "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:30362558]
subset: gocheck_do_not_annotate
synonym: "interleukin-37 biosynthetic process" NARROW []
is_a: GO:0001816 ! cytokine production
created_by: bc
creation_date: 2019-12-08T08:43:09Z

[Term]
id: GO:0150155
name: interleukin-34 production
namespace: biological_process
def: "The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:26754294]
subset: gocheck_do_not_annotate
is_a: GO:0001816 ! cytokine production
created_by: bc
creation_date: 2020-01-06T16:25:25Z

[Term]
id: GO:0170055
name: lipid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators]
subset: gocheck_do_not_annotate
is_a: GO:0005215 ! transporter activity
relationship: part_of GO:0006810 ! transport
relationship: part_of GO:0009987 ! cellular process
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27252" xsd:anyURI
created_by: ew
creation_date: 2024-03-15T18:47:58Z

[Term]
id: GO:1900068
name: negative regulation of cellular response to alkaline pH
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkaline pH" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to alkalinity" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to basic pH" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to alkaline pH" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to alkalinity" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to basic pH" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to alkalinity" BROAD []
synonym: "negative regulation of cellular response to basic pH" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0071214 ! cellular response to abiotic stimulus
relationship: regulates GO:0071214 ! cellular response to abiotic stimulus
created_by: pr
creation_date: 2012-01-26T02:35:03Z

[Term]
id: GO:1900070
name: negative regulation of cellular hyperosmotic salinity response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular hyperosmotic salinity response" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to hyperosmotic salt stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0080134 ! regulation of response to stress
relationship: negatively_regulates GO:0070887 ! cellular response to chemical stimulus
relationship: negatively_regulates GO:0071214 ! cellular response to abiotic stimulus
relationship: regulates GO:0070887 ! cellular response to chemical stimulus
relationship: regulates GO:0071214 ! cellular response to abiotic stimulus
created_by: pr
creation_date: 2012-01-26T02:45:43Z

[Term]
id: GO:1900072
name: positive regulation of sulfite transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfite transmembrane transport." [GOC:TermGenie, PMID:10234785, PMID:10870099]
subset: gocheck_do_not_annotate
synonym: "activation of sulfite transport" NARROW [GOC:TermGenie]
synonym: "activation of sulphite transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sulfite transport" EXACT []
synonym: "positive regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "up-regulation of sulphite transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sulfite transport" RELATED [GOC:TermGenie]
synonym: "upregulation of sulphite transport" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0006810 ! transport
relationship: regulates GO:0006810 ! transport
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28653" xsd:anyURI
created_by: dph
creation_date: 2012-01-26T08:41:16Z

[Term]
id: GO:1900120
name: regulation of receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
created_by: bf
creation_date: 2012-02-22T11:40:53Z

[Term]
id: GO:1900121
name: negative regulation of receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding
created_by: bf
creation_date: 2012-02-22T11:40:57Z

[Term]
id: GO:1900122
name: positive regulation of receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding
created_by: bf
creation_date: 2012-02-22T11:41:00Z

[Term]
id: GO:1900130
name: regulation of lipid binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
created_by: pm
creation_date: 2012-02-23T04:05:03Z

[Term]
id: GO:1900131
name: negative regulation of lipid binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1900130 ! regulation of lipid binding
created_by: pm
creation_date: 2012-02-23T04:05:07Z

[Term]
id: GO:1900132
name: positive regulation of lipid binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of lipid binding" NARROW [GOC:TermGenie]
synonym: "up regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1900130 ! regulation of lipid binding
created_by: pm
creation_date: 2012-02-23T04:05:11Z

[Term]
id: GO:1900265
name: regulation of substance P receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:27Z

[Term]
id: GO:1900266
name: negative regulation of substance P receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "down-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "downregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "inhibition of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "negative regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:36Z

[Term]
id: GO:1900267
name: positive regulation of substance P receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "activation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "activation of substance P receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "positive regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "up-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of substance P receptor ligand" NARROW [GOC:TermGenie]
synonym: "upregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of substance P receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1900265 ! regulation of substance P receptor binding
created_by: tb
creation_date: 2012-04-03T11:11:45Z

[Term]
id: GO:1901698
name: response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to nitrogen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI
created_by: pr
creation_date: 2012-12-13T15:06:08Z

[Term]
id: GO:1901699
name: cellular response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to nitrogen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901698 ! response to nitrogen compound
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI
created_by: pr
creation_date: 2012-12-13T15:06:13Z

[Term]
id: GO:1901700
name: response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to oxygen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27194" xsd:anyURI
created_by: pr
creation_date: 2012-12-13T15:11:37Z

[Term]
id: GO:1901839
name: regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
created_by: sart
creation_date: 2013-01-23T10:24:33Z

[Term]
id: GO:1901840
name: negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1901839 ! regulation of RNA polymerase I regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
created_by: sart
creation_date: 2013-01-23T10:24:37Z

[Term]
id: GO:1901876
name: regulation of calcium ion binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051098 ! regulation of binding
relationship: regulates GO:0043167 ! ion binding
created_by: rl
creation_date: 2013-02-06T12:38:12Z

[Term]
id: GO:1901877
name: negative regulation of calcium ion binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "down regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "downregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "downregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "inhibition of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "inhibition of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding
relationship: negatively_regulates GO:0043167 ! ion binding
created_by: rl
creation_date: 2013-02-06T12:38:22Z

[Term]
id: GO:1901878
name: positive regulation of calcium ion binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188]
subset: gocheck_do_not_annotate
synonym: "activation of calcium ion binding" NARROW [GOC:TermGenie]
synonym: "activation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of calcium ion storage activity" RELATED [GOC:TermGenie]
synonym: "upregulation of calcium ion binding" EXACT [GOC:TermGenie]
synonym: "upregulation of calcium ion storage activity" RELATED [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1901876 ! regulation of calcium ion binding
relationship: positively_regulates GO:0043167 ! ion binding
created_by: rl
creation_date: 2013-02-06T12:38:26Z

[Term]
id: GO:1901976
name: regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001047
def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "regulation of G1/S transition checkpoint" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000075 ! cell cycle checkpoint signaling
relationship: regulates GO:0000075 ! cell cycle checkpoint signaling
created_by: jl
creation_date: 2013-03-06T15:10:20Z

[Term]
id: GO:1901977
name: negative regulation of cell cycle checkpoint
namespace: biological_process
alt_id: GO:2001048
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
subset: gocheck_do_not_annotate
synonym: "down regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "downregulation of cell cycle checkpoint" EXACT [GOC:TermGenie]
synonym: "inhibition of cell cycle checkpoint" NARROW [GOC:TermGenie]
synonym: "negative regulation of G1/S checkpoint" RELATED [GOC:obol]
synonym: "negative regulation of G1/S transition checkpoint" RELATED []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901976 ! regulation of cell cycle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000075 ! cell cycle checkpoint signaling
relationship: negatively_regulates GO:0000075 ! cell cycle checkpoint signaling
created_by: jl
creation_date: 2013-03-06T15:10:29Z

[Term]
id: GO:1902415
name: regulation of mRNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
subset: gocheck_do_not_annotate
is_a: GO:1905214 ! regulation of RNA binding
created_by: rb
creation_date: 2013-09-13T18:57:15Z

[Term]
id: GO:1902416
name: positive regulation of mRNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
is_a: GO:1905216 ! positive regulation of RNA binding
created_by: rb
creation_date: 2013-09-13T18:57:24Z

[Term]
id: GO:1902518
name: response to cyclophosphamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
created_by: dw
creation_date: 2013-12-02T09:34:08Z

[Term]
id: GO:1902519
name: response to docetaxel trihydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to docetaxel" RELATED []
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dw
creation_date: 2013-12-02T09:44:04Z

[Term]
id: GO:1902520
name: response to doxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dw
creation_date: 2013-12-02T09:44:13Z

[Term]
id: GO:1902521
name: response to etoposide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dw
creation_date: 2013-12-02T09:44:22Z

[Term]
id: GO:1902522
name: response to 4'-epidoxorubicin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to epirubicin" RELATED []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dw
creation_date: 2013-12-02T09:44:31Z

[Term]
id: GO:1902595
name: regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
created_by: mah
creation_date: 2013-12-19T16:19:39Z

[Term]
id: GO:1902596
name: negative regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "down regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "downregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ARS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of ARS binding" NARROW [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding
created_by: mah
creation_date: 2013-12-19T16:19:48Z

[Term]
id: GO:1902597
name: positive regulation of DNA replication origin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415]
subset: gocheck_do_not_annotate
synonym: "activation of ARS binding" NARROW [GOC:TermGenie]
synonym: "activation of DNA replication origin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of DNA replication origin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ARS binding" NARROW [GOC:TermGenie]
synonym: "upregulation of DNA replication origin binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1902595 ! regulation of DNA replication origin binding
created_by: mah
creation_date: 2013-12-19T16:19:57Z

[Term]
id: GO:1902619
name: regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
subset: gocheck_do_not_annotate
is_a: GO:1904526 ! regulation of microtubule binding
created_by: tb
creation_date: 2014-01-14T22:17:16Z

[Term]
id: GO:1902620
name: positive regulation of microtubule minus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule minus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule minus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1902619 ! regulation of microtubule minus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding
created_by: tb
creation_date: 2014-01-14T22:17:25Z

[Term]
id: GO:1903025
name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
created_by: dph
creation_date: 2014-05-15T17:55:54Z

[Term]
id: GO:1903026
name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
created_by: dph
creation_date: 2014-05-15T17:56:00Z

[Term]
id: GO:1903031
name: regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
is_a: GO:1904526 ! regulation of microtubule binding
created_by: hjd
creation_date: 2014-05-16T18:38:26Z

[Term]
id: GO:1903032
name: negative regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
synonym: "down regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule plus-end binding" NARROW [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904527 ! negative regulation of microtubule binding
created_by: hjd
creation_date: 2014-05-16T18:38:32Z

[Term]
id: GO:1903033
name: positive regulation of microtubule plus-end binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule plus-end binding" NARROW [GOC:TermGenie]
synonym: "up regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule plus-end binding" EXACT [GOC:TermGenie]
is_a: GO:1903031 ! regulation of microtubule plus-end binding
is_a: GO:1904528 ! positive regulation of microtubule binding
created_by: hjd
creation_date: 2014-05-16T18:38:38Z

[Term]
id: GO:1903046
name: meiotic cell cycle process
namespace: biological_process
def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
subset: goslim_pombe
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022414 ! reproductive process
disjoint_from: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0022414 ! reproductive process
created_by: jl
creation_date: 2014-05-22T14:22:28Z

[Term]
id: GO:1903047
name: mitotic cell cycle process
namespace: biological_process
def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
created_by: jl
creation_date: 2014-05-22T14:22:34Z

[Term]
id: GO:1903491
name: response to simvastatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0036273 ! response to statin
created_by: hp
creation_date: 2014-09-25T10:58:06Z

[Term]
id: GO:1903504
name: regulation of mitotic spindle checkpoint
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).
subset: gocheck_do_not_annotate
synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie]
is_a: GO:0090231 ! regulation of spindle checkpoint
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071174 ! mitotic spindle checkpoint signaling
relationship: regulates GO:0071174 ! mitotic spindle checkpoint signaling
created_by: al
creation_date: 2014-10-01T13:52:57Z

[Term]
id: GO:1903642
name: regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
subset: gocheck_do_not_annotate
synonym: "regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
created_by: al
creation_date: 2014-11-21T12:02:22Z

[Term]
id: GO:1903643
name: positive regulation of recombination hotspot binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749]
subset: gocheck_do_not_annotate
synonym: "activation of DNA binding, recombination hotspot" NARROW [GOC:TermGenie]
synonym: "activation of recombination hotspot binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "up-regulation of recombination hotspot binding" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie]
synonym: "upregulation of recombination hotspot binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1903642 ! regulation of recombination hotspot binding
created_by: al
creation_date: 2014-11-21T12:02:31Z

[Term]
id: GO:1903837
name: regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
created_by: als
creation_date: 2015-01-22T11:53:59Z

[Term]
id: GO:1903838
name: negative regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "inhibition of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding
is_a: GO:1904572 ! negative regulation of mRNA binding
created_by: als
creation_date: 2015-01-22T11:54:08Z

[Term]
id: GO:1903839
name: positive regulation of mRNA 3'-UTR binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA 3' UTR binding" NARROW [GOC:TermGenie]
synonym: "activation of mRNA 3'-UTR binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding
created_by: als
creation_date: 2015-01-22T11:54:17Z

[Term]
id: GO:1904424
name: regulation of GTP binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
relationship: regulates GO:0043167 ! ion binding
created_by: sl
creation_date: 2015-07-02T20:34:44Z

[Term]
id: GO:1904425
name: negative regulation of GTP binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
synonym: "down regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "downregulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "inhibition of GTP binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904424 ! regulation of GTP binding
relationship: negatively_regulates GO:0043167 ! ion binding
created_by: sl
creation_date: 2015-07-02T20:35:01Z

[Term]
id: GO:1904426
name: positive regulation of GTP binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546]
subset: gocheck_do_not_annotate
synonym: "activation of GTP binding" NARROW [GOC:TermGenie]
synonym: "up regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of GTP binding" EXACT [GOC:TermGenie]
synonym: "upregulation of GTP binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904424 ! regulation of GTP binding
relationship: positively_regulates GO:0043167 ! ion binding
created_by: sl
creation_date: 2015-07-02T20:35:07Z

[Term]
id: GO:1904432
name: regulation of ferrous iron binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
relationship: regulates GO:0043167 ! ion binding
created_by: kom
creation_date: 2015-07-06T13:46:30Z

[Term]
id: GO:1904433
name: negative regulation of ferrous iron binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "down regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "downregulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "inhibition of ferrous iron binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding
relationship: negatively_regulates GO:0043167 ! ion binding
created_by: kom
creation_date: 2015-07-06T13:46:36Z

[Term]
id: GO:1904434
name: positive regulation of ferrous iron binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "activation of ferrous iron binding" NARROW [GOC:TermGenie]
synonym: "up regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of ferrous iron binding" EXACT [GOC:TermGenie]
synonym: "upregulation of ferrous iron binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1904432 ! regulation of ferrous iron binding
relationship: positively_regulates GO:0043167 ! ion binding
created_by: kom
creation_date: 2015-07-06T13:46:42Z

[Term]
id: GO:1904435
name: regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
is_a: GO:1900120 ! regulation of receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:01Z

[Term]
id: GO:1904436
name: negative regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "down regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of transferrin receptor binding" NARROW [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:07Z

[Term]
id: GO:1904437
name: positive regulation of transferrin receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247]
subset: gocheck_do_not_annotate
synonym: "activation of transferrin receptor binding" NARROW [GOC:TermGenie]
synonym: "up regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of transferrin receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of transferrin receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1904435 ! regulation of transferrin receptor binding
created_by: kom
creation_date: 2015-07-06T13:49:13Z

[Term]
id: GO:1904475
name: regulation of small GTPase binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "regulation of Ras GTPase binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18750" xsd:anyURI
created_by: sl
creation_date: 2015-07-10T22:47:31Z

[Term]
id: GO:1904476
name: negative regulation of small GTPase binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "down regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of Ras GTPase binding" EXACT [GOC:TermGenie]
synonym: "downregulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "inhibition of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of Ras GTPase binding" NARROW []
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904475 ! regulation of small GTPase binding
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18750" xsd:anyURI
created_by: sl
creation_date: 2015-07-10T22:47:38Z

[Term]
id: GO:1904477
name: positive regulation of small GTPase binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216]
subset: gocheck_do_not_annotate
synonym: "activation of Ras GTPase binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of Ras GTPase binding" NARROW []
synonym: "up regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of small GTPase binding" EXACT [GOC:TermGenie]
synonym: "upregulation of small GTPase binding" EXACT [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904475 ! regulation of small GTPase binding
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18750" xsd:anyURI
created_by: sl
creation_date: 2015-07-10T22:47:43Z

[Term]
id: GO:1904526
name: regulation of microtubule binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
created_by: als
creation_date: 2015-07-30T10:32:13Z

[Term]
id: GO:1904527
name: negative regulation of microtubule binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "down regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "downregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule binding" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "inhibition of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding
created_by: als
creation_date: 2015-07-30T10:32:29Z

[Term]
id: GO:1904528
name: positive regulation of microtubule binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "activation of microtubule binding" NARROW [GOC:TermGenie]
synonym: "activation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "activation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule binding" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule severing activity" RELATED [GOC:TermGenie]
synonym: "upregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904526 ! regulation of microtubule binding
created_by: als
creation_date: 2015-07-30T10:32:36Z

[Term]
id: GO:1904529
name: regulation of actin filament binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904616 ! regulation of actin binding
created_by: als
creation_date: 2015-07-30T10:41:49Z

[Term]
id: GO:1904530
name: negative regulation of actin filament binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "down regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "downregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "downregulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "inhibition of actin filament binding" NARROW [GOC:TermGenie]
synonym: "inhibition of F-actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904617 ! negative regulation of actin binding
created_by: als
creation_date: 2015-07-30T10:41:55Z

[Term]
id: GO:1904531
name: positive regulation of actin filament binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051]
subset: gocheck_do_not_annotate
synonym: "activation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "activation of actin filament binding" NARROW [GOC:TermGenie]
synonym: "activation of F-actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of F-actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of actin cross-linking activity" RELATED [GOC:TermGenie]
synonym: "upregulation of actin filament binding" EXACT [GOC:TermGenie]
synonym: "upregulation of F-actin binding" EXACT [GOC:TermGenie]
is_a: GO:1904529 ! regulation of actin filament binding
is_a: GO:1904618 ! positive regulation of actin binding
created_by: als
creation_date: 2015-07-30T10:42:01Z

[Term]
id: GO:1904572
name: negative regulation of mRNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA binding" NARROW [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
is_a: GO:1905215 ! negative regulation of RNA binding
created_by: sl
creation_date: 2015-08-19T17:51:03Z

[Term]
id: GO:1904573
name: regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1902415 ! regulation of mRNA binding
created_by: sl
creation_date: 2015-08-19T17:51:09Z

[Term]
id: GO:1904574
name: negative regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "down regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "downregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "downregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "inhibition of SECIS binding" NARROW [GOC:TermGenie]
synonym: "inhibition of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of SECIS binding" EXACT [GOC:TermGenie]
is_a: GO:1904572 ! negative regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding
created_by: sl
creation_date: 2015-08-19T17:51:15Z

[Term]
id: GO:1904575
name: positive regulation of selenocysteine insertion sequence binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792]
subset: gocheck_do_not_annotate
synonym: "activation of SECIS binding" NARROW [GOC:TermGenie]
synonym: "activation of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
synonym: "upregulation of SECIS binding" EXACT [GOC:TermGenie]
synonym: "upregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding
created_by: sl
creation_date: 2015-08-19T17:51:21Z

[Term]
id: GO:1904616
name: regulation of actin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
created_by: mr
creation_date: 2015-08-27T19:08:56Z

[Term]
id: GO:1904617
name: negative regulation of actin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "down regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "down-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "downregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of actin binding" NARROW [GOC:TermGenie]
synonym: "inhibition of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding
created_by: mr
creation_date: 2015-08-27T19:09:02Z

[Term]
id: GO:1904618
name: positive regulation of actin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557]
subset: gocheck_do_not_annotate
synonym: "activation of actin binding" NARROW [GOC:TermGenie]
synonym: "activation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "up-regulation of actin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane associated actin binding" NARROW [GOC:TermGenie]
synonym: "upregulation of actin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane associated actin binding" NARROW [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1904616 ! regulation of actin binding
created_by: mr
creation_date: 2015-08-27T19:09:08Z

[Term]
id: GO:1904742
name: regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
created_by: nc
creation_date: 2015-10-19T12:18:48Z

[Term]
id: GO:1904743
name: negative regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "down regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "inhibition of telomere binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding
created_by: nc
creation_date: 2015-10-19T12:18:55Z

[Term]
id: GO:1904744
name: positive regulation of telomeric DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
subset: gocheck_do_not_annotate
synonym: "activation of telomere binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of telomeric repeat binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of telomeric repeat binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomere binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of telomeric repeat binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1904742 ! regulation of telomeric DNA binding
created_by: nc
creation_date: 2015-10-19T12:19:01Z

[Term]
id: GO:1904793
name: regulation of euchromatin binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
is_a: GO:0035561 ! regulation of chromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:04Z

[Term]
id: GO:1904794
name: negative regulation of euchromatin binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "down regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "downregulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "inhibition of euchromatin binding" NARROW [GOC:TermGenie]
is_a: GO:0035562 ! negative regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:12Z

[Term]
id: GO:1904795
name: positive regulation of euchromatin binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "activation of euchromatin binding" NARROW [GOC:TermGenie]
synonym: "up regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of euchromatin binding" EXACT [GOC:TermGenie]
synonym: "upregulation of euchromatin binding" EXACT [GOC:TermGenie]
is_a: GO:0035563 ! positive regulation of chromatin binding
is_a: GO:1904793 ! regulation of euchromatin binding
created_by: nc
creation_date: 2015-11-09T11:43:19Z

[Term]
id: GO:1904796
name: regulation of core promoter binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
created_by: nc
creation_date: 2015-11-09T12:32:23Z

[Term]
id: GO:1904797
name: negative regulation of core promoter binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "down regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "downregulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "inhibition of core promoter binding" NARROW [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding
created_by: nc
creation_date: 2015-11-09T12:32:31Z

[Term]
id: GO:1904798
name: positive regulation of core promoter binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415]
subset: gocheck_do_not_annotate
synonym: "activation of core promoter binding" NARROW [GOC:TermGenie]
synonym: "up regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of core promoter binding" EXACT [GOC:TermGenie]
synonym: "upregulation of core promoter binding" EXACT [GOC:TermGenie]
is_a: GO:1904796 ! regulation of core promoter binding
is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding
created_by: nc
creation_date: 2015-11-09T12:32:38Z

[Term]
id: GO:1905119
name: response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dw
creation_date: 2016-04-08T12:36:39Z

[Term]
id: GO:1905120
name: cellular response to haloperidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1905119 ! response to haloperidol
created_by: dw
creation_date: 2016-04-08T12:36:47Z

[Term]
id: GO:1905214
name: regulation of RNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
created_by: bf
creation_date: 2016-06-06T10:20:56Z

[Term]
id: GO:1905215
name: negative regulation of RNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1905214 ! regulation of RNA binding
created_by: bf
creation_date: 2016-06-06T10:21:04Z

[Term]
id: GO:1905216
name: positive regulation of RNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
subset: gocheck_do_not_annotate
synonym: "activation of RNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905214 ! regulation of RNA binding
created_by: bf
creation_date: 2016-06-06T10:21:12Z

[Term]
id: GO:1905493
name: regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G quartet binding" BROAD [GOC:TermGenie]
synonym: "regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of G-quartet binding" BROAD [GOC:TermGenie]
synonym: "regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051101 ! regulation of DNA binding
created_by: ans
creation_date: 2016-09-26T14:53:21Z

[Term]
id: GO:1905494
name: negative regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "down regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of G quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of G-quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "inhibition of tetraplex DNA binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1905493 ! regulation of G-quadruplex DNA binding
created_by: ans
creation_date: 2016-09-26T14:53:29Z

[Term]
id: GO:1905495
name: positive regulation of G-quadruplex DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "activation of G quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of G-quartet DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of quadruplex DNA binding" NARROW [GOC:TermGenie]
synonym: "activation of tetraplex DNA binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of G-quartet DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of quadruplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of tetraplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1905493 ! regulation of G-quadruplex DNA binding
created_by: ans
creation_date: 2016-09-26T14:53:37Z

[Term]
id: GO:1905496
name: regulation of triplex DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
is_a: GO:0051101 ! regulation of DNA binding
created_by: ans
creation_date: 2016-09-26T14:57:09Z

[Term]
id: GO:1905497
name: negative regulation of triplex DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "down regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of triplex DNA binding" NARROW [GOC:TermGenie]
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:1905496 ! regulation of triplex DNA binding
created_by: ans
creation_date: 2016-09-26T14:57:17Z

[Term]
id: GO:1905498
name: positive regulation of triplex DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245]
subset: gocheck_do_not_annotate
synonym: "activation of triplex DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of triplex DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of triplex DNA binding" EXACT [GOC:TermGenie]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:1905496 ! regulation of triplex DNA binding
created_by: ans
creation_date: 2016-09-26T14:57:25Z

[Term]
id: GO:1905595
name: regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900120 ! regulation of receptor binding
created_by: nc
creation_date: 2016-10-26T10:57:23Z

[Term]
id: GO:1905596
name: negative regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "down regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of LDL receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie]
synonym: "negative regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "negative regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900121 ! negative regulation of receptor binding
is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding
created_by: nc
creation_date: 2016-10-26T10:57:31Z

[Term]
id: GO:1905597
name: positive regulation of low-density lipoprotein particle receptor binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
subset: gocheck_do_not_annotate
synonym: "activation of LDL receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie]
synonym: "activation of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie]
synonym: "positive regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "positive regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "up regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of LDL receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie]
synonym: "upregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie]
is_a: GO:1900122 ! positive regulation of receptor binding
is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding
created_by: nc
creation_date: 2016-10-26T10:57:40Z

[Term]
id: GO:1905610
name: regulation of mRNA cap binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
is_a: GO:1902415 ! regulation of mRNA binding
created_by: bc
creation_date: 2016-10-28T11:27:28Z

[Term]
id: GO:1905611
name: negative regulation of mRNA cap binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
synonym: "down regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "downregulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "inhibition of mRNA cap binding" NARROW [GOC:TermGenie]
is_a: GO:1904572 ! negative regulation of mRNA binding
is_a: GO:1905610 ! regulation of mRNA cap binding
created_by: bc
creation_date: 2016-10-28T11:27:36Z

[Term]
id: GO:1905612
name: positive regulation of mRNA cap binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027]
subset: gocheck_do_not_annotate
synonym: "activation of mRNA cap binding" NARROW [GOC:TermGenie]
synonym: "up regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of mRNA cap binding" EXACT [GOC:TermGenie]
synonym: "upregulation of mRNA cap binding" EXACT [GOC:TermGenie]
is_a: GO:1902416 ! positive regulation of mRNA binding
is_a: GO:1905610 ! regulation of mRNA cap binding
created_by: bc
creation_date: 2016-10-28T11:27:43Z

[Term]
id: GO:1905636
name: positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531]
subset: gocheck_do_not_annotate
synonym: "activation of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie]
is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding
created_by: bc
creation_date: 2016-11-03T12:03:07Z

[Term]
id: GO:1905767
name: regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
is_a: GO:1904742 ! regulation of telomeric DNA binding
created_by: nc
creation_date: 2016-12-20T15:33:58Z

[Term]
id: GO:1905768
name: negative regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
synonym: "down regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "downregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "inhibition of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie]
is_a: GO:1904743 ! negative regulation of telomeric DNA binding
is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding
created_by: nc
creation_date: 2016-12-20T15:34:07Z

[Term]
id: GO:1905769
name: positive regulation of double-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185]
subset: gocheck_do_not_annotate
synonym: "activation of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie]
is_a: GO:1904744 ! positive regulation of telomeric DNA binding
is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding
created_by: nc
creation_date: 2016-12-20T15:34:15Z

[Term]
id: GO:1905853
name: regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
relationship: regulates GO:0043167 ! ion binding
created_by: bc
creation_date: 2017-01-23T13:25:30Z

[Term]
id: GO:1905854
name: negative regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "down regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "downregulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "inhibition of heparan sulfate binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:1905853 ! regulation of heparan sulfate binding
relationship: negatively_regulates GO:0043167 ! ion binding
created_by: bc
creation_date: 2017-01-23T13:25:38Z

[Term]
id: GO:1905855
name: positive regulation of heparan sulfate binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "activation of heparan sulfate binding" NARROW [GOC:TermGenie]
synonym: "up regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heparan sulfate binding" EXACT [GOC:TermGenie]
synonym: "upregulation of heparan sulfate binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:1905853 ! regulation of heparan sulfate binding
relationship: positively_regulates GO:0043167 ! ion binding
created_by: bc
creation_date: 2017-01-23T13:25:47Z

[Term]
id: GO:1905858
name: regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
created_by: bc
creation_date: 2017-01-23T14:25:10Z

[Term]
id: GO:1905859
name: negative regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "down regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "down regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "down-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "downregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "downregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "inhibition of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie]
synonym: "inhibition of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "negative regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding
created_by: bc
creation_date: 2017-01-23T14:25:19Z

[Term]
id: GO:1905860
name: positive regulation of heparan sulfate proteoglycan binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668]
subset: gocheck_do_not_annotate
synonym: "activation of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie]
synonym: "activation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "positive regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "up regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "up regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "up-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
synonym: "upregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie]
synonym: "upregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding
created_by: bc
creation_date: 2017-01-23T14:25:27Z

[Term]
id: GO:1990054
name: response to temozolomide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2013-02-22T10:09:44Z

[Term]
id: GO:1990466
name: protein autosumoylation
namespace: biological_process
def: "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663]
subset: gocheck_do_not_annotate
synonym: "protein auto-sumoylation" EXACT []
synonym: "protein self-sumoylation" EXACT []
is_a: GO:0018193 ! peptidyl-amino acid modification
created_by: se
creation_date: 2014-08-25T22:37:21Z

[Term]
id: GO:1990636
name: reproductive senescence
namespace: biological_process
def: "A life cycle stage during which the reproductive capacity and fitness of an organism declines." [PMID:24914937, PMID:25523082, PMID:27353257]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_annotate
synonym: "ovarian senescence" NARROW []
is_a: GO:0044848 ! biological phase
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22733" xsd:anyURI
created_by: sl
creation_date: 2015-02-10T23:17:56Z

[Term]
id: GO:1990775
name: endothelin production
namespace: biological_process
def: "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]
subset: gocheck_do_not_annotate
synonym: "EDN1 production" NARROW []
synonym: "EDN2 production" NARROW []
synonym: "EDN3 production" NARROW []
synonym: "endothelin secretion" NARROW []
synonym: "endothelin-1 secretion" NARROW []
synonym: "endothelin-2 production" NARROW []
synonym: "endothelin-3 production" NARROW []
is_a: GO:0001816 ! cytokine production
created_by: sl
creation_date: 2015-06-15T23:13:18Z

[Term]
id: GO:1990968
name: modulation by host of RNA binding by virus
namespace: biological_process
def: "A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA." [GOC:bf, GOC:PARL, PMID:25116364]
comment: Note that the bound RNA may originate from the virus or another organism, including the host.
subset: gocheck_do_not_annotate
synonym: "modulation by host of viral protein:RNA interaction" RELATED [GOC:bf]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms
is_a: GO:1905214 ! regulation of RNA binding
created_by: bf
creation_date: 2016-06-21T11:56:10Z

[Term]
id: GO:2000656
name: regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0043393 ! regulation of protein binding
created_by: vk
creation_date: 2011-05-02T05:33:41Z

[Term]
id: GO:2000657
name: negative regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding
created_by: vk
creation_date: 2011-05-02T05:33:44Z

[Term]
id: GO:2000658
name: positive regulation of apolipoprotein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]
subset: gocheck_do_not_annotate
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2000656 ! regulation of apolipoprotein binding
created_by: vk
creation_date: 2011-05-02T05:33:46Z

[Term]
id: GO:2000677
name: regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0051101 ! regulation of DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:11Z

[Term]
id: GO:2000678
name: negative regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:14Z

[Term]
id: GO:2000679
name: positive regulation of transcription regulatory region DNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding
created_by: yaf
creation_date: 2011-05-09T03:28:17Z

[Term]
id: GO:2001263
name: regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0043393 ! regulation of protein binding
created_by: yaf
creation_date: 2011-12-09T01:13:54Z

[Term]
id: GO:2001264
name: negative regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding
created_by: yaf
creation_date: 2011-12-09T01:14:01Z

[Term]
id: GO:2001265
name: positive regulation of C-C chemokine binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding." [GOC:obol]
subset: gocheck_do_not_annotate
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:2001263 ! regulation of C-C chemokine binding
created_by: yaf
creation_date: 2011-12-09T01:14:07Z

[Typedef]
id: ends_during
name: ends during
namespace: external
xref: RO:0002093

[Typedef]
id: happens_during
name: happens during
namespace: external
xref: RO:0002092
is_transitive: true
is_a: ends_during ! ends during

[Typedef]
id: has_ontology_root_term
name: has ontology root term
namespace: external
xref: IAO:0000700
is_metadata_tag: true
is_class_level: true

[Typedef]
id: has_part
name: has part
namespace: external
xref: BFO:0000051
is_transitive: true

[Typedef]
id: negatively_regulates
name: negatively regulates
namespace: external
xref: RO:0002212
is_a: regulates ! regulates

[Typedef]
id: occurs_in
name: occurs in
namespace: external
xref: BFO:0000066
transitive_over: part_of ! part of

[Typedef]
id: part_of
name: part of
namespace: external
xref: BFO:0000050
is_transitive: true
inverse_of: has_part ! has part

[Typedef]
id: positively_regulates
name: positively regulates
namespace: external
xref: RO:0002213
holds_over_chain: negatively_regulates negatively_regulates
is_a: regulates ! regulates

[Typedef]
id: regulates
name: regulates
namespace: external
xref: RO:0002211
is_transitive: true

[Typedef]
id: starts_during
name: starts during
namespace: external
xref: RO:0002091

[Typedef]
id: term_tracker_item
name: term tracker item
namespace: external
xref: IAO:0000233
is_metadata_tag: true
is_class_level: true