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"created_terms": { "biological_process": [ { "id": "GO:0014000", "name": "morula development" }, { "id": "GO:0120532", "name": "glycosaminoglycan-protein linkage region biosynthetic process" }, { "id": "GO:0120540", "name": "chondroitin sulfate proteoglycan biosynthetic process, enzymatic modification" }, { "id": "GO:0120541", "name": "dermatan sulfate proteoglycan biosynthetic process, enzymatic modification" }, { "id": "GO:0140001", "name": "morula formation" }, { "id": "GO:0160221", "name": "Rho-activating G protein-coupled receptor signaling pathway" }, { "id": "GO:0170062", "name": "nutrient storage" }, { "id": "GO:0170063", "name": "transmembrane transport from lysosomal lumen to cytosol" } ], "molecular_function": [ { "id": "GO:0120531", "name": "prenyl diphosphate synthase activity" }, { "id": "GO:0120533", "name": "glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (non-phosphorylating) activity" }, { "id": "GO:0120534", "name": "dermatan sulfotransferase activity" }, { "id": "GO:0120536", "name": "heptaprenylglyceryl phosphate synthase activity" }, { "id": "GO:0120537", "name": "3-demethylubiquinone 3-O-methyltransferase activity" }, { "id": "GO:0120538", "name": "2-methoxy-6-polyprenolphenol 4-hydroxylase activity" }, { "id": "GO:0120539", "name": "4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity" }, { "id": "GO:0140002", "name": "histone H3K4me3 reader activity" }, { "id": "GO:0140003", "name": "histone H3K36me3 reader activity" }, { "id": "GO:0140004", "name": "histone H3Q5ser reader activity" }, { "id": "GO:0140005", "name": "histone H4K20me2 reader activity" }, { "id": "GO:0140006", "name": "histone H3 reader activity" }, { "id": "GO:0140008", "name": "histone H4 reader activity" }, { "id": "GO:0140011", "name": "histone H4K12ac reader activity" }, { "id": "GO:0140012", "name": "histone H4K5ac reader activity" }, { "id": "GO:0140015", "name": "histone H3K14ac reader activity" }, { "id": "GO:0140017", "name": "histone H3K18cr reader activity" }, { "id": "GO:0140019", "name": "histone H3K9cr reader activity" }, { "id": "GO:0140038", "name": "histone H3K27cr reader activity" }, { "id": "GO:0140044", "name": "histone H3K18ac reader activity" }, { "id": "GO:0140046", "name": "histone H4K16ac reader activity" }, { "id": "GO:0140054", "name": "histone H2A reader activity" }, { "id": "GO:0140055", "name": "histone H4K8ac reader activity" }, { "id": "GO:0140063", "name": "unmodified histone reader activity" }, { "id": "GO:0140071", "name": "histone H2B reader activity" }, { "id": "GO:0140072", "name": "histone H3K9ac reader activity" }, { "id": "GO:0160220", "name": "D-alanine-(R)-lactate ligase activity" }, { "id": "GO:0160222", "name": "D-alanine-D-serine ligase activity" }, { "id": "GO:0160224", "name": "3-demethoxyubiquinone 3-hydroxylase (NADH) activity" }, { "id": "GO:0160225", "name": "G-quadruplex unwinding activity" }, { "id": "GO:0160228", "name": "bile acid-gated sodium channel activity" }, { "id": "GO:0160229", "name": "peroxisome-endoplasmic reticulum membrane tether activity" }, { "id": "GO:0180050", "name": "protein-mitochondrial outer membrane tethering activity" } ], "cellular_component": [ { "id": "GO:0140047", "name": "specialized extracellular matrix" }, { "id": "GO:0151001", "name": "tuft" }, { "id": "GO:0160219", "name": "cortical endoplasmic reticulum membrane" }, { "id": "GO:0160223", "name": "pyrenoid tubule" }, { "id": "GO:0160226", "name": "oligosaccharyltransferase complex A" }, { "id": "GO:0160227", "name": "oligosaccharyltransferase complex B" }, { "id": "GO:0180049", "name": "Mrh5C translation activator complex" } ] }, "obsolete_terms": { "biological_process": [ { "id": "GO:0000717", "name": "nucleotide-excision repair, DNA duplex unwinding" }, { "id": "GO:0000718", "name": "nucleotide-excision repair, DNA damage removal" }, { "id": "GO:0006025", "name": "galactosaminoglycan biosynthetic process" }, { "id": "GO:0006028", "name": "galactosaminoglycan catabolic 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"GO:0019576", "name": "aerobic fructose catabolic process" }, { "id": "GO:0031279", "name": "regulation of cyclase activity" }, { "id": "GO:0031280", "name": "negative regulation of cyclase activity" }, { "id": "GO:0031551", "name": "regulation of brain-derived neurotrophic factor-activated receptor activity" }, { "id": "GO:0032069", "name": "regulation of nuclease activity" }, { "id": "GO:0032070", "name": "regulation of deoxyribonuclease activity" }, { "id": "GO:0032073", "name": "negative regulation of restriction endodeoxyribonuclease activity" }, { "id": "GO:0032084", "name": "regulation of type I site-specific deoxyribonuclease activity" }, { "id": "GO:0032085", "name": "regulation of type II site-specific deoxyribonuclease activity" }, { "id": "GO:0032086", "name": "regulation of type III site-specific deoxyribonuclease activity" }, { "id": "GO:0032087", "name": "regulation of type IV site-specific deoxyribonuclease activity" }, { "id": "GO:0032113", "name": "regulation of 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"regulation of myosin light chain kinase activity" }, { "id": "GO:0035505", "name": "positive regulation of myosin light chain kinase activity" }, { "id": "GO:0035561", "name": "regulation of chromatin binding" }, { "id": "GO:0036167", "name": "phenotypic switching in response to host" }, { "id": "GO:0036234", "name": "deglucuronidation" }, { "id": "GO:0036235", "name": "acyl deglucuronidation" }, { "id": "GO:0036236", "name": "acyl glucuronidation" }, { "id": "GO:0036292", "name": "DNA rewinding" }, { "id": "GO:0039501", "name": "suppression by virus of host type I interferon production" }, { "id": "GO:0039519", "name": "modulation by virus of host autophagy" }, { "id": "GO:0039521", "name": "suppression by virus of host autophagy" }, { "id": "GO:0039637", "name": "catabolism by virus of host DNA" }, { "id": "GO:0042137", "name": "sequestering of neurotransmitter" }, { "id": "GO:0042192", "name": "methylmercury biosynthetic process" }, { "id": "GO:0042989", "name": "sequestering of 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"GO:0044863", "name": "modulation by virus of host cell division" }, { "id": "GO:0044864", "name": "positive regulation by virus of host cell division" }, { "id": "GO:0044869", "name": "negative regulation by host of viral exo-alpha-sialidase activity" }, { "id": "GO:0046350", "name": "galactosaminoglycan metabolic process" }, { "id": "GO:0046414", "name": "organomercury biosynthetic process" }, { "id": "GO:0046774", "name": "suppression by virus of host intracellular interferon activity" }, { "id": "GO:0046775", "name": "suppression by virus of host cytokine production" }, { "id": "GO:0050788", "name": "sequestering of mercury" }, { "id": "GO:0051004", "name": "regulation of lipoprotein lipase activity" }, { "id": "GO:0051095", "name": "regulation of helicase activity" }, { "id": "GO:0051102", "name": "DNA ligation involved in DNA recombination" }, { "id": "GO:0051103", "name": "DNA ligation involved in DNA repair" }, { "id": "GO:0051104", "name": "DNA-dependent DNA replication DNA ligation" }, { "id": "GO:0051105", "name": "regulation of DNA ligation" }, { "id": "GO:0051106", "name": "positive regulation of DNA ligation" }, { "id": "GO:0051107", "name": "negative regulation of DNA ligation" }, { "id": "GO:0051220", "name": "cytoplasmic sequestering of protein" }, { "id": "GO:0051238", "name": "sequestering of metal ion" }, { "id": "GO:0051339", "name": "regulation of lyase activity" }, { "id": "GO:0051340", "name": "regulation of ligase activity" }, { "id": "GO:0051342", "name": "regulation of cyclic-nucleotide phosphodiesterase activity" }, { "id": "GO:0051352", "name": "negative regulation of ligase activity" }, { "id": "GO:0052089", "name": "modulation by symbiont of host salicylic acid-mediated defense response" }, { "id": "GO:0052173", "name": "response to defenses of other organism" }, { "id": "GO:0052318", "name": "regulation of phytoalexin metabolic process" }, { "id": "GO:0052319", "name": "regulation of phytoalexin biosynthetic process" }, { "id": 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{ "id": "GO:0071407", "name": "cellular response to organic cyclic compound" }, { "id": "GO:0075528", "name": "perturbation by virus of host immune response" }, { "id": "GO:0090219", "name": "negative regulation of lipid kinase activity" }, { "id": "GO:0090441", "name": "trehalose biosynthesis in response to heat stress" }, { "id": "GO:0090442", "name": "trehalose catabolism in response to heat stress" }, { "id": "GO:0097202", "name": "activation of cysteine-type endopeptidase activity" }, { "id": "GO:0097340", "name": "inhibition of cysteine-type endopeptidase activity" }, { "id": "GO:0097577", "name": "sequestering of iron ion" }, { "id": "GO:0097578", "name": "sequestering of copper ion" }, { "id": "GO:0097579", "name": "extracellular sequestering of copper ion" }, { "id": "GO:0097580", "name": "intracellular sequestering of copper ion" }, { "id": "GO:0097615", "name": "modulation by host of symbiont type IV pilus-dependent motility" }, { "id": "GO:0097616", "name": "positive regulation by host of symbiont type IV pilus-dependent motility" }, { "id": "GO:0106246", "name": "regulation of poly(A)-specific ribonuclease activity" }, { "id": "GO:0110112", "name": "regulation of lipid transporter activity" }, { "id": "GO:0120138", "name": "regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity" }, { "id": "GO:0140133", "name": "symbiont-mediated suppression of host cytokine production" }, { "id": "GO:0141088", "name": "symbiont-mediated activation of host autophagy" }, { "id": "GO:0141132", "name": "defense response to host" }, { "id": "GO:0141199", "name": "GDP-mannose biosynthetic process from glucose" }, { "id": "GO:0150066", "name": "negative regulation of deacetylase activity" }, { "id": "GO:0150067", "name": "regulation of tubulin deacetylase activity" }, { "id": "GO:0150070", "name": "regulation of arginase activity" }, { "id": "GO:0150073", "name": "regulation of protein-glutamine gamma-glutamyltransferase activity" }, { "id": "GO:1900010", "name": "regulation of corticotropin-releasing hormone receptor activity" }, { "id": "GO:1900129", "name": "positive regulation of G-protein activated inward rectifier potassium channel activity" }, { "id": "GO:1900130", "name": "regulation of lipid binding" }, { "id": "GO:1900132", "name": "positive regulation of lipid binding" }, { "id": "GO:1900161", "name": "regulation of phospholipid scramblase activity" }, { "id": "GO:1900169", "name": "regulation of glucocorticoid mediated signaling pathway" }, { "id": "GO:1900170", "name": "negative regulation of glucocorticoid mediated signaling pathway" }, { "id": "GO:1900171", "name": "positive regulation of glucocorticoid mediated signaling pathway" }, { "id": "GO:1900259", "name": "regulation of RNA-dependent RNA polymerase activity" }, { "id": "GO:1900262", "name": "regulation of DNA-directed DNA polymerase activity" }, { "id": "GO:1900265", "name": "regulation of substance P receptor binding" }, { "id": "GO:1900266", "name": "negative regulation of substance P receptor binding" }, { "id": "GO:1900267", "name": "positive regulation of substance P receptor binding" }, { "id": "GO:1900276", "name": "regulation of proteinase activated receptor activity" }, { "id": "GO:1900757", "name": "regulation of D-amino-acid oxidase activity" }, { "id": "GO:1901004", "name": "ubiquinone-6 metabolic process" }, { "id": "GO:1901005", "name": "ubiquinone-6 catabolic process" }, { "id": "GO:1901006", "name": "ubiquinone-6 biosynthetic process" }, { "id": "GO:1901182", "name": "regulation of camalexin biosynthetic process" }, { "id": "GO:1901376", "name": "organic heteropentacyclic compound metabolic process" }, { "id": "GO:1901377", "name": "organic heteropentacyclic compound catabolic process" }, { "id": "GO:1901378", "name": "organic heteropentacyclic compound biosynthetic process" }, { "id": "GO:1901615", "name": "organic hydroxy compound metabolic process" }, { "id": "GO:1901616", "name": "organic hydroxy compound catabolic process" }, { "id": "GO:1901617", "name": "organic hydroxy compound biosynthetic process" }, { "id": "GO:1901664", "name": "regulation of NAD+ ADP-ribosyltransferase activity" }, { "id": "GO:1901839", "name": "regulation of RNA polymerase I regulatory region sequence-specific DNA binding" }, { "id": "GO:1901840", "name": "negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding" }, { "id": "GO:1901878", "name": "positive regulation of calcium ion binding" }, { "id": "GO:1901917", "name": "regulation of exoribonuclease activity" }, { "id": "GO:1901918", "name": "negative regulation of exoribonuclease activity" }, { "id": "GO:1901968", "name": "regulation of polynucleotide 3'-phosphatase activity" }, { "id": "GO:1902162", "name": "regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" }, { "id": "GO:1902163", "name": "negative regulation of DNA damage response, signal 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precursor protein catabolic process" }, { "id": "GO:1902970", "name": "premeiotic DNA replication DNA duplex unwinding" }, { "id": "GO:1902971", "name": "mitotic DNA replication DNA duplex unwinding" }, { "id": "GO:1902972", "name": "premeiotic DNA replication DNA ligation" }, { "id": "GO:1902973", "name": "mitotic DNA replication DNA ligation" }, { "id": "GO:1903015", "name": "regulation of exo-alpha-sialidase activity" }, { "id": "GO:1903021", "name": "regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" }, { "id": "GO:1903031", "name": "regulation of microtubule plus-end binding" }, { "id": "GO:1903032", "name": "negative regulation of microtubule plus-end binding" }, { "id": "GO:1903123", "name": "regulation of thioredoxin peroxidase activity" }, { "id": "GO:1903167", "name": "regulation of pyrroline-5-carboxylate reductase activity" }, { "id": "GO:1903168", "name": "positive regulation of pyrroline-5-carboxylate reductase activity" }, { "id": "GO:1903176", "name": "regulation of tyrosine 3-monooxygenase activity" }, { "id": "GO:1903178", "name": "positive regulation of tyrosine 3-monooxygenase activity" }, { "id": "GO:1903182", "name": "regulation of SUMO transferase activity" }, { "id": "GO:1903198", "name": "regulation of L-dopa decarboxylase activity" }, { "id": "GO:1903200", "name": "positive regulation of L-dopa decarboxylase activity" }, { "id": "GO:1903218", "name": "regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" }, { "id": "GO:1903279", "name": "regulation of calcium:sodium antiporter activity" }, { "id": "GO:1903299", "name": "regulation of hexokinase activity" }, { "id": "GO:1903590", "name": "regulation of lysozyme activity" }, { "id": "GO:1903610", "name": "regulation of calcium-dependent ATPase activity" }, { "id": "GO:1903622", "name": "regulation of RNA polymerase III activity" }, { "id": "GO:1903630", "name": "regulation of aminoacyl-tRNA ligase activity" }, { "id": "GO:1903642", "name": "regulation of recombination hotspot binding" }, { "id": "GO:1903643", "name": "positive regulation of recombination hotspot binding" }, { "id": "GO:1903652", "name": "modulation by virus of host cytoplasmic transport" }, { "id": "GO:1903667", "name": "regulation of chemorepellent activity" }, { "id": "GO:1903730", "name": "regulation of phosphatidate phosphatase activity" }, { "id": "GO:1903762", "name": "positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" }, { "id": "GO:1903837", "name": "regulation of mRNA 3'-UTR binding" }, { "id": "GO:1903838", "name": "negative regulation of mRNA 3'-UTR binding" }, { "id": "GO:1903839", "name": "positive regulation of mRNA 3'-UTR binding" }, { "id": "GO:1903856", "name": "regulation of cytokinin dehydrogenase activity" }, { "id": "GO:1903868", "name": "regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" }, { "id": "GO:1903932", "name": "regulation of DNA primase activity" }, { "id": "GO:1903952", "name": "regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" }, { "id": "GO:1903995", "name": "regulation of non-membrane spanning protein tyrosine kinase activity" }, { "id": "GO:1903997", "name": "positive regulation of non-membrane spanning protein tyrosine kinase activity" }, { "id": "GO:1904005", "name": "regulation of phospholipase D activity" }, { "id": "GO:1904029", "name": "regulation of cyclin-dependent protein kinase activity" }, { "id": "GO:1904041", "name": "regulation of cystathionine beta-synthase activity" }, { "id": "GO:1904217", "name": "regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" }, { "id": "GO:1904223", "name": "regulation of glucuronosyltransferase activity" }, { "id": "GO:1904226", "name": "regulation of glycogen synthase activity, transferring glucose-1-phosphate" }, { "id": "GO:1904232", "name": "regulation of aconitate hydratase activity" }, { "id": "GO:1904245", "name": "regulation of polynucleotide adenylyltransferase activity" }, { "id": "GO:1904254", "name": "regulation of iron ion transmembrane transporter activity" }, { "id": "GO:1904295", "name": "regulation of osmolarity-sensing cation channel activity" }, { "id": "GO:1904424", "name": "regulation of GTP binding" }, { "id": "GO:1904432", "name": "regulation of ferrous iron binding" }, { "id": "GO:1904433", "name": "negative regulation of ferrous iron binding" }, { "id": "GO:1904435", "name": "regulation of transferrin receptor binding" }, { "id": "GO:1904436", "name": "negative regulation of transferrin receptor binding" }, { "id": "GO:1904475", "name": "regulation of small GTPase binding" }, { "id": "GO:1904476", "name": "negative regulation of small GTPase binding" }, { "id": "GO:1904477", "name": "positive regulation of small GTPase binding" }, { "id": "GO:1904529", "name": "regulation of actin filament binding" }, { "id": "GO:1904572", "name": "negative regulation of mRNA binding" }, { "id": "GO:1904573", "name": "regulation of selenocysteine insertion sequence binding" }, { "id": "GO:1904574", "name": "negative regulation of selenocysteine insertion sequence binding" }, { "id": "GO:1904575", "name": "positive regulation of selenocysteine insertion sequence binding" }, { "id": "GO:1904603", "name": "regulation of advanced glycation end-product receptor activity" }, { "id": "GO:1904617", "name": "negative regulation of actin binding" }, { "id": "GO:1904618", "name": "positive regulation of actin binding" }, { "id": "GO:1904732", "name": "regulation of electron transfer activity" }, { "id": "GO:1904733", "name": "negative regulation of electron transfer activity" }, { "id": "GO:1904734", "name": "positive regulation of electron transfer activity" }, { "id": "GO:1904742", "name": "regulation of telomeric DNA binding" }, { "id": "GO:1904793", "name": "regulation of euchromatin binding" }, { "id": "GO:1904794", "name": "negative regulation of euchromatin binding" }, { "id": "GO:1904795", "name": "positive regulation of euchromatin binding" }, { "id": "GO:1904796", "name": "regulation of core promoter binding" }, { "id": "GO:1904875", "name": "regulation of DNA ligase activity" }, { "id": "GO:1904877", "name": "positive regulation of DNA ligase activity" }, { "id": "GO:1905117", "name": "regulation of ribonucleoside-diphosphate reductase activity" }, { "id": "GO:1905181", "name": "regulation of urease activity" }, { "id": "GO:1905214", "name": "regulation of RNA binding" }, { "id": "GO:1905245", "name": "regulation of aspartic-type peptidase activity" }, { "id": "GO:1905246", "name": "negative regulation of aspartic-type peptidase activity" }, { "id": "GO:1905255", "name": "regulation of RNA binding transcription factor activity" }, { "id": "GO:1905271", "name": "regulation of proton-transporting ATP synthase activity, rotational mechanism" }, { "id": "GO:1905407", "name": "regulation of creatine transmembrane transporter activity" }, { "id": "GO:1905462", "name": "regulation of DNA duplex unwinding" }, { "id": "GO:1905463", "name": "negative regulation of DNA duplex unwinding" }, { "id": "GO:1905464", "name": "positive regulation of DNA duplex unwinding" }, { "id": "GO:1905465", "name": "regulation of G-quadruplex DNA unwinding" }, { "id": "GO:1905466", "name": "negative regulation of G-quadruplex DNA unwinding" }, { "id": "GO:1905467", "name": "positive regulation of G-quadruplex DNA unwinding" }, { "id": "GO:1905494", "name": "negative regulation of G-quadruplex DNA binding" }, { "id": "GO:1905495", "name": "positive regulation of G-quadruplex DNA binding" }, { "id": "GO:1905496", "name": "regulation of triplex DNA binding" }, { "id": "GO:1905497", "name": "negative regulation of triplex DNA binding" }, { "id": "GO:1905498", "name": "positive regulation of triplex DNA binding" }, { "id": "GO:1905595", "name": "regulation of low-density lipoprotein particle receptor binding" }, { "id": "GO:1905610", "name": "regulation of mRNA cap binding" }, { "id": "GO:1905611", "name": "negative regulation of mRNA cap binding" }, { "id": "GO:1905687", "name": "regulation of diacylglycerol kinase activity" }, { "id": "GO:1905689", "name": "positive regulation of diacylglycerol kinase activity" }, { "id": "GO:1905767", "name": "regulation of double-stranded telomeric DNA binding" }, { "id": "GO:1905768", "name": "negative regulation of double-stranded telomeric DNA binding" }, { "id": "GO:1905769", "name": "positive regulation of double-stranded telomeric DNA binding" }, { "id": "GO:1905774", "name": "regulation of DNA helicase activity" }, { "id": "GO:1905776", "name": "positive regulation of DNA helicase activity" }, { "id": "GO:1905777", "name": "regulation of exonuclease activity" }, { "id": "GO:1905779", "name": "positive regulation of exonuclease activity" }, { "id": "GO:1905853", "name": "regulation of heparan sulfate binding" }, { "id": "GO:1905854", "name": "negative regulation of heparan sulfate binding" }, { "id": "GO:1905855", "name": "positive regulation of heparan sulfate binding" }, { "id": "GO:1905858", "name": "regulation of heparan sulfate proteoglycan binding" }, { "id": "GO:1905859", "name": "negative regulation of heparan sulfate proteoglycan binding" }, { "id": "GO:1905860", "name": "positive regulation of heparan sulfate proteoglycan binding" }, { "id": "GO:1905918", "name": "regulation of CoA-transferase activity" }, { "id": "GO:1990659", "name": "sequestering of manganese ion" }, { "id": "GO:1990969", "name": "modulation by host of viral RNA-binding transcription factor activity" }, { "id": "GO:2000116", "name": "regulation of cysteine-type endopeptidase activity" }, { "id": "GO:2000117", "name": "negative regulation of cysteine-type endopeptidase activity" }, { "id": "GO:2000275", "name": "regulation of oxidative phosphorylation uncoupler activity" }, { "id": "GO:2000361", "name": "regulation of prostaglandin-E synthase activity" }, { "id": "GO:2000371", "name": "regulation of DNA topoisomerase (ATP-hydrolyzing) activity" }, { "id": "GO:2000372", "name": "negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity" }, { "id": "GO:2000468", "name": "regulation of peroxidase activity" }, { "id": "GO:2000469", "name": "negative regulation of peroxidase activity" }, { "id": "GO:2000656", "name": "regulation of apolipoprotein binding" }, { "id": "GO:2000658", "name": "positive regulation of apolipoprotein binding" }, { "id": "GO:2001029", "name": "regulation of cellular glucuronidation" }, { "id": "GO:2001030", "name": "negative regulation of cellular glucuronidation" }, { "id": "GO:2001031", "name": "positive regulation of cellular glucuronidation" }, { "id": "GO:2001056", "name": "positive regulation of cysteine-type endopeptidase activity" }, { "id": "GO:2001144", "name": "regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity" }, { "id": "GO:2001263", "name": "regulation of C-C chemokine binding" }, { "id": "GO:2001264", "name": "negative regulation of C-C chemokine binding" }, { "id": "GO:2001265", "name": "positive regulation of C-C chemokine binding" } ], "molecular_function": [ { "id": "GO:0010012", "name": "steroid 22-alpha hydroxylase activity" }, { "id": "GO:0016767", "name": "geranylgeranyl-diphosphate geranylgeranyltransferase activity" }, { "id": "GO:0030374", "name": "nuclear receptor coactivator activity" }, { "id": "GO:0033207", "name": "beta-1,4-N-acetylgalactosaminyltransferase activity" }, { "id": "GO:0033208", "name": "UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity" }, { "id": "GO:0033778", "name": "7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity" }, { "id": "GO:0033779", "name": "5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity" }, { "id": "GO:0033871", "name": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity" }, { "id": "GO:0033872", "name": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity" }, { "id": "GO:0046537", "name": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity" }, { "id": "GO:0046538", "name": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity" }, { "id": "GO:0052608", "name": "echinenone 3-hydroxylase activity" }, { "id": "GO:0052609", "name": "4-ketotorulene 3-hydroxylase activity" }, { "id": "GO:0052610", "name": "beta-cryptoxanthin hydroxylase activity" }, { "id": "GO:0052611", "name": "beta-carotene 3-hydroxylase activity" }, { "id": "GO:0052612", "name": "adonirubin 3-hydroxylase activity" }, { "id": "GO:0052613", "name": "canthaxanthin 3-hydroxylase activity" }, { "id": "GO:0052739", "name": "phosphatidylserine 1-acylhydrolase activity" }, { "id": "GO:0052850", "name": "NADPH-dependent dihydrocurcumin reductase activity" }, { "id": "GO:0070643", "name": "vitamin D 25-hydroxylase activity" }, { "id": "GO:0072555", "name": "17-beta-ketosteroid reductase (NADPH) activity" }, { "id": "GO:0080076", "name": "caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity" }, { "id": "GO:0097159", "name": "organic cyclic compound binding" }, { "id": "GO:0102191", "name": "3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity" }, { "id": "GO:0140536", "name": "nuclear receptor corepressor activity" }, { "id": "GO:1901618", "name": "organic hydroxy compound transmembrane transporter activity" } ], "cellular_component": [ { "id": "GO:0099053", "name": "activating signal cointegrator 1 complex" } ] }, "merged_terms": {}, "meta_statements": { "biological_process": [ { "id": "GO:0000162", "name": "L-tryptophan biosynthetic process", "changes": { "name": { "current": "L-tryptophan biosynthetic process", "previous": "tryptophan biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate.\" [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.\" [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]" }, "synonyms": { "current": [ "\"aromatic amino acid family biosynthetic process, anthranilate pathway\" EXACT []", "\"L-tryptophan anabolism\" EXACT []", "\"L-tryptophan biosynthesis\" EXACT []", "\"tryptophan biosynthetic process\" RELATED []", "\"tryptophan formation\" EXACT []", "\"tryptophan synthesis\" RELATED []" ], "previous": [ "\"aromatic amino acid family biosynthetic process, anthranilate pathway\" EXACT []", "\"tryptophan anabolism\" EXACT []", "\"tryptophan biosynthesis\" EXACT []", "\"tryptophan formation\" EXACT []", "\"tryptophan synthesis\" EXACT []" ] } } }, { "id": "GO:0001576", "name": "globoside biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a glycosphingolipid with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).\" [ISBN:0198506732]", "previous": "\"The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).\" [ISBN:0198506732]" } } }, { "id": "GO:0001824", "name": "blastocyst development", "changes": { "definition": { "current": "\"The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "previous": "\"The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]" }, "synonyms": { "current": [ "\"blastula development\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001825", "name": "blastocyst formation", "changes": { "synonyms": { "current": [ "\"blastula formation\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001832", "name": "blastocyst growth", "changes": { "synonyms": { "current": [ "\"blastula growth\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0001835", "name": "blastocyst hatching", "changes": { "synonyms": { "current": [ "\"blastula hatching\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0003012", "name": "muscle system process", "changes": { "definition": { "current": "\"An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.\" [GOC:mtg_cardio]", "previous": "\"A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.\" [GOC:mtg_cardio]" } } }, { "id": "GO:0003013", "name": "circulatory system process", "changes": { "definition": { "current": "\"An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.\" [GOC:mtg_cardio]", "previous": "\"A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.\" [GOC:mtg_cardio]" } } }, { "id": "GO:0003014", "name": "renal system process", "changes": { "definition": { "current": "\"An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).\" [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]", "previous": "\"A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).\" [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]" } } }, { "id": "GO:0006127", "name": "glycerol-3-phosphate shuttle", "changes": { "name": { "current": "glycerol-3-phosphate shuttle", "previous": "glycerophosphate shuttle" }, "definition": { "current": "\"The process of transferring reducing equivalents from NADH in the cytosol into the mitochondria via glycerol-3-phosphate. Cytosolic glycerol-3-phosphate dehydrogenase uses NADH to convert dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate (G3P) in the cytosol; G3P then diffuses into the mitochondria where mitochondrial glycerol-3-phosphate dehydrogenase uses FAD to convert G3P back to DHAP; the electrons on the reduced FADH2 are then available for use in the electron transport chain, and DHAP returns to the cytosol to complete the cycle.\" [GOC:sjm, PMID:16368075]", "previous": "\"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.\" [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075]" }, "synonyms": { "current": [ "\"glycerol phosphate shuttle\" EXACT []", "\"glycerophosphate shuttle\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0006568", "name": "L-tryptophan metabolic process", "changes": { "name": { "current": "L-tryptophan metabolic process", "previous": "tryptophan metabolic process" }, "synonyms": { "current": [ "\"tryptophan metabolic process\" RELATED []", "\"tryptophan metabolism\" RELATED []" ], "previous": [ "\"tryptophan metabolism\" EXACT []" ] } } }, { "id": "GO:0006569", "name": "L-tryptophan catabolic process", "changes": { "name": { "current": "L-tryptophan catabolic process", "previous": "tryptophan catabolic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.\" [ISBN:0198547684]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.\" [ISBN:0198547684]" }, "synonyms": { "current": [ "\"tryptophan breakdown\" EXACT []", "\"tryptophan catabolic process\" RELATED []", "\"tryptophan catabolic process, using tryptophanase\" NARROW []", "\"tryptophan catabolism\" EXACT []", "\"tryptophan catabolism, using tryptophanase\" NARROW []", "\"tryptophan degradation\" EXACT []" ], "previous": [ "\"tryptophan breakdown\" EXACT []", "\"tryptophan catabolic process, using tryptophanase\" NARROW []", "\"tryptophan catabolism\" EXACT []", "\"tryptophan catabolism, using tryptophanase\" NARROW []", "\"tryptophan degradation\" EXACT []" ] } } }, { "id": "GO:0006601", "name": "creatine biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.\" [GOC:mah, MetaCyc:GLYCGREAT-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.\" [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]" } } }, { "id": "GO:0006675", "name": "mannosyl-inositol phosphorylceramide metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.\" [GOC:ai]", "previous": "\"The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative.\" [GOC:ai, MetaCyc:MIPC]" } } }, { "id": "GO:0008153", "name": "4-aminobenzoate biosynthetic process", "changes": { "name": { "current": "4-aminobenzoate biosynthetic process", "previous": "para-aminobenzoic acid biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]", "previous": "\"The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]" }, "synonyms": { "current": [ "\"4-aminobenzoic acid biosynthesis\" EXACT []", "\"4-aminobenzoic acid biosynthetic process\" EXACT []", "\"p-aminobenzoic acid biosynthesis\" EXACT []", "\"p-aminobenzoic acid biosynthetic process\" EXACT []", "\"PABA biosynthesis\" EXACT []", "\"PABA biosynthetic process\" EXACT []", "\"para-aminobenzoic acid anabolism\" EXACT []", "\"para-aminobenzoic acid biosynthesis\" EXACT []", "\"para-aminobenzoic acid biosynthetic process\" EXACT []", "\"para-aminobenzoic acid formation\" EXACT []", "\"para-aminobenzoic acid synthesis\" EXACT []", "\"vitamin Bx biosynthesis\" EXACT []", "\"vitamin Bx biosynthetic process\" EXACT []" ], "previous": [ "\"4-aminobenzoic acid biosynthesis\" EXACT []", "\"4-aminobenzoic acid biosynthetic process\" EXACT []", "\"p-aminobenzoic acid biosynthesis\" EXACT []", "\"p-aminobenzoic acid biosynthetic process\" EXACT []", "\"PABA biosynthesis\" EXACT []", "\"PABA biosynthetic process\" EXACT []", "\"para-aminobenzoic acid anabolism\" EXACT []", "\"para-aminobenzoic acid biosynthesis\" EXACT []", "\"para-aminobenzoic acid formation\" EXACT []", "\"para-aminobenzoic acid synthesis\" EXACT []", "\"vitamin Bx biosynthesis\" EXACT []", "\"vitamin Bx biosynthetic process\" EXACT []" ] } } }, { "id": "GO:0009626", "name": "plant-type hypersensitive response", "changes": { "comment": { "current": "Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185.", "previous": "Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'." } } }, { "id": "GO:0010134", "name": "sulfate assimilation via adenylyl sulfate reduction", "changes": { "definition": { "current": "\"The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase.\" [MetaCyc:SULFMETII-PWY]", "previous": "\"The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase.\" [EC:1.8.99.2]" } } }, { "id": "GO:0010889", "name": "regulation of triglyceride storage", "changes": { "name": { "current": "regulation of triglyceride storage", "previous": "regulation of sequestering of triglyceride" }, "synonyms": { "current": [ "\"regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"regulation of sequestering of triglyceride\" EXACT []", "\"regulation of triacylglycerol sequestration\" EXACT [GOC:dph, GOC:tb]" ], "previous": [ "\"regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"regulation of triacylglycerol sequestration\" EXACT [GOC:dph, GOC:tb]" ] } } }, { "id": "GO:0010890", "name": "positive regulation of triglyceride storage", "changes": { "name": { "current": "positive regulation of triglyceride storage", "previous": "positive regulation of sequestering of triglyceride" }, "synonyms": { "current": [ "\"positive regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"positive regulation of sequestering of triglyceride\" EXACT []", "\"positive regulation of triglyceride sequestration\" EXACT [GOC:dph, GOC:tb]" ], "previous": [ "\"positive regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"positive regulation of triglyceride sequestration\" EXACT [GOC:dph, GOC:tb]" ] } } }, { "id": "GO:0010891", "name": "negative regulation of triglyceride storage", "changes": { "name": { "current": "negative regulation of triglyceride storage", "previous": "negative regulation of sequestering of triglyceride" }, "synonyms": { "current": [ "\"negative regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"negative regulation of sequestering of triglyceride\" EXACT []", "\"negative regulation of triglyceride sequestration\" EXACT [GOC:dph, GOC:tb]" ], "previous": [ "\"negative regulation of sequestering of triacylglycerol\" EXACT [GOC:mah]", "\"negative regulation of triglyceride sequestration\" EXACT [GOC:dph, GOC:tb]" ] } } }, { "id": "GO:0015014", "name": "heparan sulfate proteoglycan biosynthetic process, chain elongation", "changes": { "name": { "current": "heparan sulfate proteoglycan biosynthetic process, chain elongation", "previous": "heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" }, "synonyms": { "current": [ "\"heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process\" EXACT []", "\"heparan sulfate proteoglycan chain elongation\" EXACT []", "\"heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"heparan sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []", "\"heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process\" RELATED []" ], "previous": [ "\"heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"heparan sulfate proteoglycan chain elongation\" EXACT []", "\"heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"heparan sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []", "\"heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process\" RELATED []" ] } } }, { "id": "GO:0015787", "name": "UDP-glucuronate transmembrane transport", "changes": { "name": { "current": "UDP-glucuronate transmembrane transport", "previous": "UDP-glucuronic acid transmembrane transport" }, "synonyms": { "current": [ "\"UDP-glucuronic acid transmembrane transport\" EXACT []", "\"UDP-glucuronic acid transport\" RELATED []" ], "previous": [ "\"UDP-glucuronic acid transport\" RELATED []" ] } } }, { "id": "GO:0018868", "name": "2-aminobenzenesulfonate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [UM-BBD_pathwayID:abs]" } } }, { "id": "GO:0018873", "name": "atrazine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide.\" [UM-BBD_pathwayID:atr]" } } }, { "id": "GO:0018882", "name": "(+)-camphor metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed.\" [UM-BBD_pathwayID:cam]" } } }, { "id": "GO:0018901", "name": "2,4-dichlorophenoxyacetic acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [UM-BBD_pathwayID:2\\,4d]" } } }, { "id": "GO:0018952", "name": "parathion metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [UM-BBD_pathwayID:pthn]" } } }, { "id": "GO:0018970", "name": "toluene metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.\" [UM-BBD_pathwayID:tol]" } } }, { "id": "GO:0018983", "name": "Z-phenylacetaldoxime metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.\" [UM-BBD_pathwayID:pao]", "previous": "\"The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.\" [UM-BBD_pathwayID:car]" } } }, { "id": "GO:0019087", "name": "symbiont-mediated transformation of host cell", "changes": { "name": { "current": "symbiont-mediated transformation of host cell", "previous": "transformation of host cell by virus" }, "definition": { "current": "\"A symbiont-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. Usually mediated by viruses.\" [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]", "previous": "\"A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication.\" [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315]" }, "synonyms": { "current": [ "\"host cell immortalization\" EXACT []", "\"host cell transformation\" EXACT []", "\"immortalization of host cell\" EXACT []", "\"immortalization of host cell by virus\" RELATED []", "\"transformation of host cell\" EXACT []", "\"transformation of host cell by virus\" EXACT []", "\"viral immortalization\" EXACT []", "\"viral transformation\" EXACT []", "\"viral transformation of host cell\" EXACT []", "\"virus-mediated transformation of host cell\" RELATED []" ], "previous": [ "\"host cell immortalization\" EXACT []", "\"host cell transformation\" EXACT []", "\"immortalization of host cell\" EXACT []", "\"immortalization of host cell by virus\" RELATED []", "\"transformation of host cell\" EXACT []", "\"viral immortalization\" EXACT []", "\"viral transformation\" EXACT []", "\"viral transformation of host cell\" EXACT []" ] } } }, { "id": "GO:0019329", "name": "ammonia oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons.\" [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242]" } } }, { "id": "GO:0019339", "name": "parathion catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [MetaCyc:PARATHION-DEGRADATION-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.\" [UM-BBD_pathwayID:pthn]" } } }, { "id": "GO:0019381", "name": "atrazine catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.\" [GOC:jl, MetaCyc:PWY-5724]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.\" [GOC:jl, UM-BBD_pathwayID:atr]" } } }, { "id": "GO:0019383", "name": "(+)-camphor catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone.\" [MetaCyc:P601-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone.\" [UM-BBD_pathwayID:cam]" } } }, { "id": "GO:0019391", "name": "glucuronoside catabolic process", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "glucuronoside catabolic process", "previous": "obsolete glucuronoside catabolic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue.\" [PMID:28389557]", "previous": "\"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue.\" [ISBN:0198506732]" }, "comment": { "current": "Note that this term was reinstated from obsolete.", "previous": "The reason for obsoletion is that this term represents a molecular function." } } }, { "id": "GO:0019417", "name": "sulfur oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.\" [GOC:jl]", "previous": "\"The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.\" [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]" } } }, { "id": "GO:0019434", "name": "sophorosyloxydocosanoate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon.\" [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE]" } } }, { "id": "GO:0019440", "name": "L-tryptophan catabolic process to indole-3-acetate", "changes": { "name": { "current": "L-tryptophan catabolic process to indole-3-acetate", "previous": "tryptophan catabolic process to indole-3-acetate" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including indole-3-acetate.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate.\" [GOC:go_curators]" }, "synonyms": { "current": [ "\"tryptophan breakdown to indole-3-acetate\" EXACT []", "\"tryptophan catabolic process to IAA\" EXACT []", "\"tryptophan catabolic process to indole-3-acetate\" EXACT []", "\"tryptophan catabolic process to indoleacetic acid\" EXACT []", "\"tryptophan catabolism to indoleacetic acid\" EXACT []", "\"tryptophan degradation to indole-3-acetate\" EXACT []" ], "previous": [ "\"tryptophan breakdown to indole-3-acetate\" EXACT []", "\"tryptophan catabolic process to IAA\" EXACT []", "\"tryptophan catabolic process to indoleacetic acid\" EXACT []", "\"tryptophan catabolism to indoleacetic acid\" EXACT []", "\"tryptophan degradation to indole-3-acetate\" EXACT []" ] } } }, { "id": "GO:0019441", "name": "L-tryptophan catabolic process to kynurenine", "changes": { "name": { "current": "L-tryptophan catabolic process to kynurenine", "previous": "tryptophan catabolic process to kynurenine" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including kynurenine.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.\" [GOC:go_curators]" }, "synonyms": { "current": [ "\"tryptophan breakdown to kynurenine\" EXACT []", "\"tryptophan catabolic process to kynurenine\" EXACT []", "\"tryptophan degradation to kynurenine\" EXACT []" ], "previous": [ "\"tryptophan breakdown to kynurenine\" EXACT []", "\"tryptophan degradation to kynurenine\" EXACT []" ] } } }, { "id": "GO:0019442", "name": "L-tryptophan catabolic process to acetyl-CoA", "changes": { "name": { "current": "L-tryptophan catabolic process to acetyl-CoA", "previous": "tryptophan catabolic process to acetyl-CoA" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including acetyl-CoA.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.\" [GOC:go_curators]" }, "synonyms": { "current": [ "\"tryptophan breakdown to acetyl-CoA\" EXACT []", "\"tryptophan catabolic process to acetyl-CoA\" EXACT []", "\"tryptophan degradation to acetyl-CoA\" EXACT []" ], "previous": [ "\"tryptophan breakdown to acetyl-CoA\" EXACT []", "\"tryptophan degradation to acetyl-CoA\" EXACT []" ] } } }, { "id": "GO:0019444", "name": "L-tryptophan catabolic process to catechol", "changes": { "name": { "current": "L-tryptophan catabolic process to catechol", "previous": "tryptophan catabolic process to catechol" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L-tryptophan into other compounds, including catechol.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol.\" [GOC:go_curators]" }, "synonyms": { "current": [ "\"tryptophan breakdown to catechol\" EXACT []", "\"tryptophan catabolic process to catechol\" EXACT []", "\"tryptophan degradation to catechol\" EXACT []" ], "previous": [ "\"tryptophan breakdown to catechol\" EXACT []", "\"tryptophan degradation to catechol\" EXACT []" ] } } }, { "id": "GO:0019490", "name": "2-aminobenzenesulfonate desulfonation", "changes": { "definition": { "current": "\"The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [MetaCyc:2ASDEG-PWY]", "previous": "\"The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.\" [UM-BBD_pathwayID:abs]" } } }, { "id": "GO:0019517", "name": "L-threonine catabolic process to D-lactate", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate.\" [GOC:bf, GOC:jl, MetaCyc:THRDLCTCAT-PWY]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate.\" [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY]" } } }, { "id": "GO:0019662", "name": "non-glycolytic fermentation", "changes": { "definition": { "current": "\"Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.\" [GOC:jl]", "previous": "\"Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.\" [GOC:jl, MetaCyc:Fermentation]" } } }, { "id": "GO:0019665", "name": "anaerobic amino acid catabolic process", "changes": { "definition": { "current": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP.\" [GOC:curators, GOC:jl]", "previous": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP.\" [GOC:curators, GOC:jl, MetaCyc:Fermentation]" } } }, { "id": "GO:0030730", "name": "triglyceride storage", "changes": { "name": { "current": "triglyceride storage", "previous": "sequestering of triglyceride" }, "synonyms": { "current": [ "\"retention of triacylglycerol\" EXACT []", "\"retention of triglyceride\" EXACT []", "\"sequestering of triacylglycerol\" EXACT []", "\"sequestering of triglyceride\" EXACT []", "\"sequestration of triacylglycerol\" EXACT []", "\"sequestration of triglyceride\" EXACT []", "\"storage of triacylglycerol\" EXACT []", "\"storage of triglyceride\" EXACT []", "\"triacylglycerol retention\" EXACT []", "\"triacylglycerol sequestering\" EXACT []", "\"triacylglycerol sequestration\" EXACT []", "\"triacylglycerol storage\" EXACT []", "\"triglyceride retention\" EXACT []", "\"triglyceride sequestering\" EXACT []", "\"triglyceride sequestration\" EXACT []" ], "previous": [ "\"retention of triacylglycerol\" EXACT []", "\"retention of triglyceride\" EXACT []", "\"sequestering of triacylglycerol\" EXACT []", "\"sequestration of triacylglycerol\" EXACT []", "\"sequestration of triglyceride\" EXACT []", "\"storage of triacylglycerol\" EXACT []", "\"storage of triglyceride\" EXACT []", "\"triacylglycerol retention\" EXACT []", "\"triacylglycerol sequestering\" EXACT []", "\"triacylglycerol sequestration\" EXACT []", "\"triacylglycerol storage\" EXACT []", "\"triglyceride retention\" EXACT []", "\"triglyceride sequestering\" EXACT []", "\"triglyceride sequestration\" EXACT []", "\"triglyceride storage\" EXACT []" ] } } }, { "id": "GO:0031959", "name": "nuclear receptor-mediated mineralocorticoid signaling pathway", "changes": { "definition": { "current": "\"A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.\" [PMID:11027914, PMID:12606724, PMID:15240347]", "previous": "\"A nuclear receptor-mediated signaling pathway initiated by a mineralocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.\" [PMID:11027914, PMID:12606724]" } } }, { "id": "GO:0033108", "name": "mitochondrial respiratory chain complex assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex or between respiratory chain complexes to form high-order structures.\" [GOC:mah]", "previous": "\"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.\" [GOC:mah]" } } }, { "id": "GO:0033302", "name": "quercetin O-glucoside metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving O-glucosylated derivatives of quercetin.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving O-glucosylated derivatives of quercetin.\" [GOC:mah, MetaCyc:PWY-5321]" } } }, { "id": "GO:0033321", "name": "homomethionine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]" } } }, { "id": "GO:0033322", "name": "L-homomethionine biosynthetic process", "changes": { "name": { "current": "L-homomethionine biosynthetic process", "previous": "homomethionine biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-homomethionine, a non-protein amino acid synthesized from L-methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]", "previous": "\"The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation.\" [GOC:mah, MetaCyc:PWY-1186]" }, "synonyms": { "current": [ "\"homomethionine anabolism\" EXACT []", "\"homomethionine biosynthesis\" EXACT []", "\"homomethionine biosynthetic process\" EXACT []", "\"homomethionine formation\" EXACT []", "\"homomethionine synthesis\" EXACT []" ], "previous": [ "\"homomethionine anabolism\" EXACT []", "\"homomethionine biosynthesis\" EXACT []", "\"homomethionine formation\" EXACT []", "\"homomethionine synthesis\" EXACT []" ] } } }, { "id": "GO:0033329", "name": "kaempferol O-glucoside metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol.\" [GOC:mah, MetaCyc:PWY-5320]" } } }, { "id": "GO:0033331", "name": "ent-kaurene metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.\" [GOC:mah, PMID:17064690]", "previous": "\"The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins.\" [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]" } } }, { "id": "GO:0033359", "name": "lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.\" [GOC:mah, MetaCyc:DAPLYSINESYN-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps.\" [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-]" } } }, { "id": "GO:0033383", "name": "geranyl diphosphate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes.\" [GOC:mah, MetaCyc:PWY-5122]" } } }, { "id": "GO:0033385", "name": "geranylgeranyl diphosphate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins.\" [GOC:mah, MetaCyc:PWY-5120]" } } }, { "id": "GO:0033386", "name": "geranylgeranyl diphosphate biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate.\" [GOC:mah, MetaCyc:PWY-5120]" } } }, { "id": "GO:0033387", "name": "putrescine biosynthetic process from arginine, via ornithine", "changes": { "name": { "current": "putrescine biosynthetic process from arginine, via ornithine", "previous": "putrescine biosynthetic process from ornithine" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine, via decarboxylation of ornithine.\" [GOC:mah, MetaCyc:PWY-46]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine.\" [GOC:mah, MetaCyc:PWY-46]" }, "synonyms": { "current": [ "\"putrescine anabolism from ornithine\" EXACT []", "\"putrescine biosynthesis from ornithine\" EXACT []", "\"putrescine biosynthetic process from ornithine\" EXACT []", "\"putrescine formation from ornithine\" EXACT []", "\"putrescine synthesis from ornithine\" EXACT []" ], "previous": [ "\"putrescine anabolism from ornithine\" EXACT []", "\"putrescine biosynthesis from ornithine\" EXACT []", "\"putrescine formation from ornithine\" EXACT []", "\"putrescine synthesis from ornithine\" EXACT []" ] } } }, { "id": "GO:0033388", "name": "putrescine biosynthetic process from arginine", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine.\" [GOC:mah, MetaCyc:PWY-46]" } } }, { "id": "GO:0033389", "name": "putrescine biosynthetic process from arginine, via agmatine", "changes": { "name": { "current": "putrescine biosynthetic process from arginine, via agmatine", "previous": "putrescine biosynthetic process from arginine, using agmatinase" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from arginine via agmatine.\" [GOC:mah, MetaCyc:PWY-40]", "previous": "\"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step.\" [GOC:mah, MetaCyc:PWY-40]" }, "synonyms": { "current": [ "\"putrescine anabolism from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthesis from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthetic process from arginine, using agmatinase\" EXACT []", "\"putrescine formation from arginine, using agmatinase\" EXACT []", "\"putrescine synthesis from arginine, using agmatinase\" EXACT []" ], "previous": [ "\"putrescine anabolism from arginine, using agmatinase\" EXACT []", "\"putrescine biosynthesis from arginine, using agmatinase\" EXACT []", "\"putrescine formation from arginine, using agmatinase\" EXACT []", "\"putrescine synthesis from arginine, using agmatinase\" EXACT []" ] } } }, { "id": "GO:0033499", "name": "galactose catabolic process via UDP-galactose", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.\" [GOC:mah, MetaCyc:PWY-3821]" } } }, { "id": "GO:0033621", "name": "nuclear mRNA surveillance of meiosis-specific transcripts", "changes": { "name": { "current": "nuclear mRNA surveillance of meiosis-specific transcripts", "previous": "nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts" }, "synonyms": { "current": [ "\"degradation of meiosis-specific transcripts\" EXACT []", "\"mRNA breakdown, meiosis-specific transcripts\" EXACT []", "\"mRNA catabolism, meiosis-specific transcripts\" EXACT []", "\"mRNA degradation, meiosis-specific transcripts\" EXACT []", "\"nuclear mRNA catabolic process, meiosis-specific transcripts\" EXACT []", "\"nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts\" EXACT []" ], "previous": [ "\"degradation of meiosis-specific transcripts\" EXACT []", "\"mRNA breakdown, meiosis-specific transcripts\" EXACT []", "\"mRNA catabolism, meiosis-specific transcripts\" EXACT []", "\"mRNA degradation, meiosis-specific transcripts\" EXACT []", "\"nuclear mRNA catabolic process, meiosis-specific transcripts\" EXACT []" ] } } }, { "id": "GO:0034055", "name": "effector-mediated activation of host programmed cell death by symbiont", "changes": { "name": { "current": "effector-mediated activation of host programmed cell death by symbiont", "previous": "effector-mediated activation of programmed cell death in host" }, "synonyms": { "current": [ "\"activation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"effector-mediated activation of programmed cell death in host\" EXACT []", "\"effector-mediated induction of programmed cell death in host\" EXACT []", "\"enhancement by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related PCD\" EXACT [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related programmed cell death\" RELATED []", "\"stimulation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"up regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"up-regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"upregulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]" ], "previous": [ "\"activation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"effector-mediated induction of programmed cell death in host\" EXACT []", "\"enhancement by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related PCD\" EXACT [GOC:pamgo_curators]", "\"positive regulation by symbiont of host defense-related programmed cell death\" RELATED []", "\"stimulation by symbiont of host defense-related programmed cell death\" NARROW [GOC:pamgo_curators]", "\"up regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"up-regulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]", "\"upregulation by symbiont of host defense-related programmed cell death\" EXACT [GOC:pamgo_curators]" ] } } }, { "id": "GO:0034077", "name": "butanediol metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123]", "previous": "\"The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [ISBN:0911910123, MetaCyc:BUTANEDIOL]" } } }, { "id": "GO:0034078", "name": "butanediol catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]" } } }, { "id": "GO:0034079", "name": "butanediol biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:P125-PWY]", "previous": "\"The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3.\" [GOC:mah, ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]" } } }, { "id": "GO:0039520", "name": "symbiont-mediated activation of host autophagy", "changes": { "name": { "current": "symbiont-mediated activation of host autophagy", "previous": "induction by virus of host autophagy" }, "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. For example, some viruses are able to activate host autophagy as a cellular survival mechanism, hence delaying or inhibiting apoptosis.\" [GOC:bf, GOC:sp, VZ:846]", "previous": "\"Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.\" [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846]" }, "synonyms": { "current": [ "\"activation of host autophagy by virus\" EXACT [UniProtKB-KW:KW-1072]", "\"autophagy of host cells involved in interaction with symbiont\" RELATED []", "\"induction by virus of host autophagy\" NARROW []", "\"positive regulation by virus of host autophagy\" BROAD [GOC:bf]" ], "previous": [ "\"activation of host autophagy by virus\" EXACT [UniProtKB-KW:KW-1072]", "\"autophagy of host cells involved in interaction with symbiont\" RELATED []", "\"positive regulation by virus of host autophagy\" BROAD [GOC:bf]" ] } } }, { "id": "GO:0039522", "name": "symbiont-mediated suppression of host mRNA export from nucleus", "changes": { "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp, PMID:22334672]", "previous": "\"A process in which a symbiont inhibits or disrupts the normal movement of mRNA from the nucleus to the cytoplasm of the host cell, leading to shutoff of host protein expression. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp]" } } }, { "id": "GO:0039587", "name": "symbiont-mediated-mediated suppression of host tetherin activity", "changes": { "name": { "current": "symbiont-mediated-mediated suppression of host tetherin activity", "previous": "suppression by virus of host tetherin activity" }, "definition": { "current": "\"Any process in which a symbiont stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.\" [PMID:22493439]", "previous": "\"Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.\" [PMID:22493439]" }, "synonyms": { "current": [ "\"evasion of suppression of viral release by host via inhibition of host tetherin activity\" NARROW []", "\"inhibition of host BST2/Tetherin by virus\" EXACT []", "\"suppression by virus of host tetherin activity\" EXACT []" ], "previous": [ "\"inhibition of host BST2/Tetherin by virus\" EXACT []" ] } } }, { "id": "GO:0039635", "name": "symbiont-mediated suppression of host peptidoglycan biosynthetic process", "changes": { "name": { "current": "symbiont-mediated suppression of host peptidoglycan biosynthetic process", "previous": "suppression by virus of host peptidoglycan biosynthetic process" }, "definition": { "current": "\"Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls, and phages have mechanisms to disrupt their host's cell walls.\" [GOC:bf, GOC:bm, GOC:jl]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.\" [GOC:bf, GOC:bm, GOC:jl]" }, "synonyms": { "current": [ "\"suppression by virus of host peptidoglycan biosynthetic process\" NARROW []", "\"viral inhibition of host peptidoglycan biosynthesis\" RELATED [GOC:bf]" ], "previous": [ "\"viral inhibition of host peptidoglycan biosynthesis\" RELATED [GOC:bf]" ] } } }, { "id": "GO:0039636", "name": "symbiont-mediated suppression of host cell wall biogenesis", "changes": { "name": { "current": "symbiont-mediated suppression of host cell wall biogenesis", "previous": "suppression by virus of host cell wall biogenesis" }, "synonyms": { "current": [ "\"suppression by virus of host cell wall biogenesis\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0039671", "name": "symbiont-mediated perturbation of host natural killer cell mediated immune response", "changes": { "name": { "current": "symbiont-mediated perturbation of host natural killer cell mediated immune response", "previous": "evasion by virus of host natural killer cell activity" }, "definition": { "current": "\"A process in which a symbiont alters or subverts the natural killer cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]", "previous": "\"Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells.\" [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]" }, "synonyms": { "current": [ "\"evasion by virus of host natural killer cell activity\" NARROW []", "\"evasion by virus of host natural killer cell response\" EXACT []", "\"evasion by virus of host NK cell killing\" EXACT [GOC:bf]", "\"modulation of host NK-cell activity by virus\" RELATED [UniProtKB-KW:KW-1131]", "\"protection by virus against host NK cell cytotoxicity\" EXACT [PMID:12782710]", "\"suppression by virus of host natural killer cell function\" NARROW [PMID:15640804]", "\"viral immunoevasion of host NK cell\" NARROW [GOC:bf]" ], "previous": [ "\"evasion by virus of host natural killer cell response\" EXACT []", "\"evasion by virus of host NK cell killing\" EXACT [GOC:bf]", "\"modulation of host NK-cell activity by virus\" RELATED [UniProtKB-KW:KW-1131]", "\"protection by virus against host NK cell cytotoxicity\" EXACT [PMID:12782710]", "\"suppression by virus of host natural killer cell function\" EXACT [PMID:15640804]", "\"viral immunoevasion of host NK cell\" EXACT [GOC:bf]" ] } } }, { "id": "GO:0039672", "name": "symbiont-mediated suppression of host natural killer cell activation", "changes": { "name": { "current": "symbiont-mediated suppression of host natural killer cell activation", "previous": "suppression by virus of host natural killer cell activation" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts natural killer cell activation in the host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:10799855]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host.\" [GOC:bf, GOC:jl]" }, "synonyms": { "current": [ "\"suppression by virus of host natural killer cell activation\" NARROW []", "\"suppression by virus of host NK-cell activation\" EXACT []" ], "previous": [ "\"suppression by virus of host NK-cell activation\" EXACT [GOC:bf, GOC:jl]" ] } } }, { "id": "GO:0039673", "name": "symbiont-mediated suppression of host dendritic cell mediated immune response", "changes": { "name": { "current": "symbiont-mediated suppression of host dendritic cell mediated immune response", "previous": "evasion by virus of host dendritic cell activity" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the dendritic cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]", "previous": "\"Any process by which a virus avoids the effects mediated by the host organism's dendritic cells.\" [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]" }, "synonyms": { "current": [ "\"evasion by virus of host dendritic cell activity\" RELATED []", "\"evasion by virus of host dendritic cell response\" EXACT []", "\"impairing dendritic cell function by virus\" EXACT [UniProtKB-KW:KW-1118]", "\"modulation of host dendritic cell activity by virus\" BROAD [UniProtKB-KW:KW-1118]" ], "previous": [ "\"evasion by virus of host dendritic cell response\" EXACT []", "\"impairing dendritic cell function by virus\" EXACT [UniProtKB-KW:KW-1118]", "\"modulation of host dendritic cell activity by virus\" BROAD [UniProtKB-KW:KW-1118]" ] } } }, { "id": "GO:0042199", "name": "cyanuric acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.\" [UM-BBD_pathwayID:cya]" } } }, { "id": "GO:0042201", "name": "N-cyclopropylmelamine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.\" [UM-BBD_pathwayID:cpm]" } } }, { "id": "GO:0042203", "name": "toluene catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\" [UM-BBD_pathwayID:tol]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\" [GOC:go_curators]" } } }, { "id": "GO:0042212", "name": "cresol metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.\" [UM-BBD_pathwayID:mcr]" } } }, { "id": "GO:0042783", "name": "symbiont-mediated evasion of host immune response", "changes": { "name": { "current": "symbiont-mediated evasion of host immune response", "previous": "evasion of host immune response" }, "synonyms": { "current": [ "\"active evasion of host immune response\" RELATED []", "\"active evasion of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion\" BROAD []", "\"evasion by virus of host immune response\" RELATED []", "\"evasion of host immune response\" EXACT []", "\"evasion or tolerance of host immune response\" BROAD []", "\"immune evasion\" EXACT []", "\"mitigation by virus of host immune response\" RELATED []", "\"mitigation of host immune response\" RELATED []", "\"mitigation of host immune response by virus\" RELATED []", "\"passive evasion of host immune response\" RELATED []", "\"passive evasion of immune response of other organism involved in symbiotic interaction\" RELATED []", "\"passive immune evasion\" RELATED []", "\"suppression by virus of host immune response\" RELATED []" ], "previous": [ "\"active evasion of host immune response\" RELATED []", "\"active evasion of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion\" BROAD []", "\"evasion by virus of host immune response\" RELATED []", "\"evasion or tolerance of host immune response\" BROAD []", "\"immune evasion\" EXACT []", "\"mitigation by virus of host immune response\" RELATED []", "\"mitigation of host immune response\" RELATED []", "\"mitigation of host immune response by virus\" RELATED []", "\"passive evasion of host immune response\" RELATED []", "\"passive evasion of immune response of other organism involved in symbiotic interaction\" RELATED []", "\"passive immune evasion\" RELATED []", "\"suppression by virus of host immune response\" RELATED []" ] } } }, { "id": "GO:0042921", "name": "nuclear receptor-mediated glucocorticoid signaling pathway", "changes": { "definition": { "current": "\"A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.\" [PMID:15240347]", "previous": "\"A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.\" [GOC:mah]" } } }, { "id": "GO:0043039", "name": "tRNA aminoacylation", "changes": { "definition": { "current": "\"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.\" [GOC:ma, GOC:mah]", "previous": "\"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.\" [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]" } } }, { "id": "GO:0043490", "name": "malate-aspartate shuttle", "changes": { "definition": { "current": "\"The process of transferring reducing equivalents from NADH in the cytosol to the mitochondria via malate. Cytosolic aspartate aminotransferase converts aspartate to oxaloacetate, and cytosolic malate dehydrogenase uses NADH to convert oxaloacetate to malate in the cytosol; the malate-alpha-ketoglutarate carrier then transports the malate into the mitochondria where mitochondrial malate dehydrogenase uses NAD to convert malate back to oxaloacetate; the electrons on the reduced NADH are then available for use in the electron transport chain; mitochondrial aspartate aminotransferase converts oxaloacetate to aspartate, and the glutamate-aspartate carrier transports the aspartate back to the cytosol to complete the cycle.\" [GOC:sjm, PMID:16368075]", "previous": "\"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesize malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.\" [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]" } } }, { "id": "GO:0044865", "name": "symbiont-mediated suppression of host cell division", "changes": { "name": { "current": "symbiont-mediated suppression of host cell division", "previous": "negative regulation by virus of host cell division" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the normal execution of cell division in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:24218612]", "previous": "\"Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division.\" [GOC:jl]" }, "synonyms": { "current": [ "\"inhibition by virus of host cell division\" NARROW []", "\"negative regulation by virus of host cell division\" NARROW []" ], "previous": [ "\"inhibition by virus of host cell division\" NARROW []" ] } } }, { "id": "GO:0046300", "name": "2,4-dichlorophenoxyacetic acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:ai, UM-BBD_pathwayID:2\\,4-d]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.\" [GOC:ai]" } } }, { "id": "GO:0046494", "name": "rhizobactin 1021 metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.\" [PMID:11274118]", "previous": "\"The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.\" [MetaCyc:PWY-761, PMID:11274118]" } } }, { "id": "GO:0046499", "name": "S-adenosylmethioninamine metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.\" [GOC:mah]", "previous": "\"The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt.\" [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]" } } }, { "id": "GO:0046597", "name": "host-mediated suppression of symbiont invasion", "changes": { "name": { "current": "host-mediated suppression of symbiont invasion", "previous": "negative regulation of viral entry into host cell" }, "definition": { "current": "\"A process in which a host inhibits or disrupts the entry of a symbiont into a host cell.\" [PMID:23544079]", "previous": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.\" [GOC:jl]" }, "synonyms": { "current": [ "\"blocking of symbiont entry into host cell\" EXACT []", "\"negative regulation of symbiont entry into host cell\" RELATED []", "\"negative regulation of viral entry into host cell\" NARROW []", "\"negative regulation of viral penetration into host cell\" EXACT []", "\"prevention of symbiont entry into host cell\" EXACT []" ], "previous": [ "\"negative regulation of viral penetration into host cell\" EXACT []" ] } } }, { "id": "GO:0050652", "name": "dermatan sulfate proteoglycan biosynthetic process, chain elongation", "changes": { "name": { "current": "dermatan sulfate proteoglycan biosynthetic process, chain elongation", "previous": "dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" }, "synonyms": { "current": [ "\"chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []", "\"chondroitin sulfate B proteoglycan chain elongation\" EXACT []", "\"dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process\" EXACT []", "\"dermatan sulfate proteoglycan chain elongation\" EXACT []", "\"dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"dermatan sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []" ], "previous": [ "\"chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []", "\"chondroitin sulfate B proteoglycan chain elongation\" EXACT []", "\"dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"dermatan sulfate proteoglycan chain elongation\" EXACT []", "\"dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"dermatan sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []" ] } } }, { "id": "GO:0050653", "name": "chondroitin sulfate proteoglycan biosynthetic process, chain elongation", "changes": { "name": { "current": "chondroitin sulfate proteoglycan biosynthetic process, chain elongation", "previous": "chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" }, "synonyms": { "current": [ "\"chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process\" EXACT []", "\"chondroitin sulfate proteoglycan chain elongation\" EXACT []", "\"chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []" ], "previous": [ "\"chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism\" EXACT []", "\"chondroitin sulfate proteoglycan chain elongation\" EXACT []", "\"chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulfate proteoglycan formation, polysaccharide chain formation\" EXACT []", "\"chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis\" EXACT []", "\"chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis\" EXACT []", "\"chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process\" EXACT []" ] } } }, { "id": "GO:0050877", "name": "nervous system process", "changes": { "definition": { "current": "\"An organ system process carried out by any of the organs or tissues of the neurological system.\" [GOC:ai, GOC:mtg_cardio]", "previous": "\"A organ system process carried out by any of the organs or tissues of neurological system.\" [GOC:ai, GOC:mtg_cardio]" } } }, { "id": "GO:0051504", "name": "diterpene phytoalexin precursor biosynthetic process", "changes": { "name": { "current": "diterpene phytoalexin precursor biosynthetic process", "previous": "diterpene phytoalexin precursor biosynthetic process pathway" } } }, { "id": "GO:0051851", "name": "host-mediated perturbation of symbiont process", "changes": { "name": { "current": "host-mediated perturbation of symbiont process", "previous": "modulation by host of symbiont process" }, "synonyms": { "current": [ "\"modification by host of symbiont morphology or physiology\" RELATED []", "\"modulation by host of symbiont process\" EXACT []" ], "previous": [ "\"modification by host of symbiont morphology or physiology\" RELATED []" ] } } }, { "id": "GO:0052081", "name": "symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway", "changes": { "definition": { "current": "\"A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:35698792]", "previous": "\"A process in which a symbiont alters or subverts a salicylic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" } } }, { "id": "GO:0052084", "name": "symbiont-mediated modulation of host ethylene-mediated defense response", "changes": { "name": { "current": "symbiont-mediated modulation of host ethylene-mediated defense response", "previous": "modulation by symbiont of host ethylene-mediated defense response" }, "synonyms": { "current": [ "\"modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction\" BROAD []", "\"modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway\" BROAD []", "\"modulation by symbiont of host ethylene-mediated defense response\" EXACT []" ], "previous": [ "\"modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction\" BROAD []", "\"modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway\" BROAD []" ] } } }, { "id": "GO:0052088", "name": "symbiont-mediated perturbation of host jasmonic acid signaling", "changes": { "name": { "current": "symbiont-mediated perturbation of host jasmonic acid signaling", "previous": "symbiont defense to host-produced jasmonic acid" }, "definition": { "current": "\"A process in which a symbiont alters or subverts a jasmonic acid-mediated signal transduction pathway in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:29222513, PMID:35698792]", "previous": "\"Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"activation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"down regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"down-regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"downregulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"induction by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"inhibition by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by organism of host JA-mediated defense response\" NARROW []", "\"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"positive regulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"suppression by organism of host JA-mediated defense response\" EXACT []", "\"suppression by symbiont of host jasmonic acid-mediated defense response\" RELATED []", "\"symbiont defense to host-produced jasmonic acid\" EXACT []", "\"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []" ], "previous": [ "\"activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"activation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"down regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"down-regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"downregulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"induction by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"inhibition by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by organism of host JA-mediated defense response\" NARROW []", "\"modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction\" NARROW []", "\"negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"negative regulation by symbiont of host jasmonic acid-mediated defense response\" NARROW []", "\"positive regulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" NARROW []", "\"positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"suppression by organism of host JA-mediated defense response\" EXACT []", "\"suppression by symbiont of host jasmonic acid-mediated defense response\" RELATED []", "\"up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []", "\"upregulation by organism of defense-related host SA-mediated signal transduction pathway\" NARROW []", "\"upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway\" NARROW []" ] } } }, { "id": "GO:0052151", "name": "symbiont-mediated activation of host apoptosis", "changes": { "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981]", "previous": "\"A process in which a symbiont gene product activates host apoptosis, leading to an increase in the frequency, rate or extent of apoptosis in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:11805081, PMID:18037263, PMID:19801898, PMID:29571981]" } } }, { "id": "GO:0052158", "name": "symbiont-mediated perturbation of host resistance gene-dependent defense response", "changes": { "name": { "current": "symbiont-mediated perturbation of host resistance gene-dependent defense response", "previous": "modulation by symbiont of host resistance gene-dependent defense response" }, "synonyms": { "current": [ "\"modulation by organism of defense response in host by specific elicitors\" EXACT []", "\"modulation by organism of host gene-for-gene resistance\" EXACT []", "\"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont\" EXACT []", "\"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of host resistance gene-dependent defense response\" EXACT []" ], "previous": [ "\"modulation by organism of defense response in host by specific elicitors\" EXACT []", "\"modulation by organism of host gene-for-gene resistance\" EXACT []", "\"modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont\" EXACT []", "\"modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction\" BROAD []" ] } } }, { "id": "GO:0052165", "name": "symbiont-mediated perturbation of host phytoalexin production", "changes": { "name": { "current": "symbiont-mediated perturbation of host phytoalexin production", "previous": "symbiont defense to host-produced phytoalexin" }, "definition": { "current": "\"Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:6870275]", "previous": "\"Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"evasion or tolerance by symbiont of host-produced phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins produced by host in response to organism\" EXACT []", "\"host phytoalexin detoxification\" NARROW []", "\"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of host phytoalexin production\" NARROW []", "\"phytoalexin detoxification\" NARROW []", "\"response to host phytoalexin production\" BROAD []", "\"response to phytoalexin production by other organism involved in symbiotic interaction\" BROAD []", "\"symbiont defense to host-produced phytoalexin\" EXACT []" ], "previous": [ "\"evasion or tolerance by symbiont of host-produced phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins\" EXACT []", "\"evasion or tolerance of phytoalexins produced by host in response to organism\" EXACT []", "\"host phytoalexin detoxification\" NARROW []", "\"modulation by organism of phytoalexin production in other organism involved in symbiotic interaction\" NARROW []", "\"modulation by symbiont of host phytoalexin production\" NARROW []", "\"phytoalexin detoxification\" NARROW []", "\"response to host phytoalexin production\" BROAD []", "\"response to phytoalexin production by other organism involved in symbiotic interaction\" BROAD []" ] } } }, { "id": "GO:0052200", "name": "symbiont-mediated response to host defenses", "changes": { "name": { "current": "symbiont-mediated response to host defenses", "previous": "response to host defenses" }, "synonyms": { "current": [ "\"maintenance of symbiont tolerance to host defense molecules\" NARROW []", "\"response of symbiont to host defense molecules\" NARROW []", "\"response to host defense molecules\" NARROW []", "\"response to host defenses\" EXACT []" ], "previous": [ "\"maintenance of symbiont tolerance to host defense molecules\" NARROW []", "\"response of symbiont to host defense molecules\" NARROW []", "\"response to host defense molecules\" NARROW []" ] } } }, { "id": "GO:0052315", "name": "phytoalexin biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response.\" [PMID:22209038, PMID:3882051, Wikipedia:Phytoalexin]", "previous": "\"The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response.\" [Wikipedia:Phytoalexin]" } } }, { "id": "GO:0052776", "name": "chitin catabolic process to fructose 6-phosphate via glucosamine", "changes": { "name": { "current": "chitin catabolic process to fructose 6-phosphate via glucosamine", "previous": "diacetylchitobiose catabolic process to glucosamine and acetate" }, "definition": { "current": "\"The pathway resulting in the breakdown of chitin into fructose 6-phosphate, via glucosamine; acetate is also produced during the process.\" [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]", "previous": "\"The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate.\" [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587]" }, "synonyms": { "current": [ "\"diacetylchitobiose catabolic process to glucosamine and acetate\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0061007", "name": "hepaticobiliary system process", "changes": { "definition": { "current": "\"A system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.\" [GOC:dph]", "previous": "\"An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.\" [GOC:dph]" } } }, { "id": "GO:0061681", "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate", "changes": { "definition": { "current": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.\" [GOC:dph, PMID:12921536]", "previous": "\"The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.\" [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536]" } } }, { "id": "GO:0061729", "name": "GDP-D-mannose biosynthetic process from fructose-6-phosphate", "changes": { "name": { "current": "GDP-D-mannose biosynthetic process from fructose-6-phosphate", "previous": "GDP-mannose biosynthetic process from fructose-6-phosphate" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of GDP-D-mannose from D-fructose-6-phosphate.\" [GOC:dph, PMID:16339137]", "previous": "\"The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate.\" [GOC:dph, PMID:16339137]" }, "synonyms": { "current": [ "\"GDP-mannose biosynthetic process from fructose-6-phosphate\" RELATED []", "\"GDP-mannose biosynthetic process from glucose\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0090357", "name": "regulation of L-tryptophan metabolic process", "changes": { "name": { "current": "regulation of L-tryptophan metabolic process", "previous": "regulation of tryptophan metabolic process" }, "synonyms": { "current": [ "\"regulation of tryptophan metabolic process\" RELATED []", "\"regulation of tryptophan metabolism\" EXACT [GOC:tb]" ], "previous": [ "\"regulation of tryptophan metabolism\" EXACT [GOC:tb]" ] } } }, { "id": "GO:0090358", "name": "positive regulation of L-tryptophan metabolic process", "changes": { "name": { "current": "positive regulation of L-tryptophan metabolic process", "previous": "positive regulation of tryptophan metabolic process" }, "synonyms": { "current": [ "\"positive regulation of tryptophan metabolic process\" RELATED []", "\"positive regulation of tryptophan metabolism\" EXACT [GOC:tb]" ], "previous": [ "\"positive regulation of tryptophan metabolism\" EXACT [GOC:tb]" ] } } }, { "id": "GO:0090399", "name": "replicative senescence", "changes": { "definition": { "current": "\"The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening.\" [PMID:17014937, PMID:23061726]", "previous": "\"A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.\" [GOC:BHF]" } } }, { "id": "GO:0097250", "name": "mitochondrial respirasome assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of respiratory enzyme complexes I, III and IV of the mitochondrial inner membrane to form a large supercomplex.\" [PMID:30030361, PMID:32311046]", "previous": "\"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.\" [GOC:mcc, PMID:21909073, PMID:22342701]" } } }, { "id": "GO:0097294", "name": "'de novo' XMP biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.\" [GOC:yaf, PMID:27590927]", "previous": "\"The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.\" [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, PMID:27590927]" } } }, { "id": "GO:0140415", "name": "effector-mediated perturbation of host defenses by symbiont", "changes": { "name": { "current": "effector-mediated perturbation of host defenses by symbiont", "previous": "effector-mediated modulation of host defenses by symbiont" }, "synonyms": { "current": [ "\"effector-mediated modulation of host defenses by symbiont\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0140418", "name": "effector-mediated perturbation of host process by symbiont", "changes": { "name": { "current": "effector-mediated perturbation of host process by symbiont", "previous": "effector-mediated modulation of host process by symbiont" }, "synonyms": { "current": [ "\"effector mediated modulation of host process by symbiont\" EXACT []", "\"effector triggered modulation of host process by symbiont\" EXACT []", "\"effector-dependent modulation of host process by symbiont\" EXACT []", "\"effector-mediated modulation of host process by symbiont\" EXACT []" ], "previous": [ "\"effector mediated modulation of host process by symbiont\" EXACT []", "\"effector triggered modulation of host process by symbiont\" EXACT []", "\"effector-dependent modulation of host process by symbiont\" EXACT []" ] } } }, { "id": "GO:0140645", "name": "neutrophil extracellular trap formation", "changes": { "name": { "current": "neutrophil extracellular trap formation", "previous": "neutrophic extracellular trap formation" } } }, { "id": "GO:0140883", "name": "symbiont-mediated activation of host reticulophagy", "changes": { "name": { "current": "symbiont-mediated activation of host reticulophagy", "previous": "induction by virus of host reticulophagy" }, "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances the normal execution of host reticulophagy, leading to an increase in the frequency, rate or extent of reticulophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:35239449]", "previous": "\"Any process in which a virus activates or increases the frequency, rate or extent of reticulophagy in the host.\" [PMID:35239449]" }, "synonyms": { "current": [ "\"activation of host reticulophagy by virus\" EXACT []", "\"induction by virus of host reticulophagy\" NARROW []", "\"positive regulation by virus of host reticulophagy\" BROAD []" ], "previous": [ "\"activation of host reticulophagy by virus\" EXACT []", "\"positive regulation by virus of host reticulophagy\" BROAD []" ] } } }, { "id": "GO:0140976", "name": "host defense response against symbiont-mediated perturbation of plasma membrane integrity", "changes": { "name": { "current": "host defense response against symbiont-mediated perturbation of plasma membrane integrity", "previous": "defense response against perturbation of plasma membrane integrity" }, "synonyms": { "current": [ "\"defense response against disruption of plasma membrane integrity\" EXACT []", "\"defense response against perturbation of plasma membrane integrity\" RELATED []" ], "previous": [ "\"defense response against disruption of plasma membrane integrity\" EXACT []" ] } } }, { "id": "GO:0141154", "name": "symbiont-mediated suppression of host-directed shutoff of host translation", "changes": { "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:20563710, PMID:21622569]", "previous": "\"A process in which a symbiont inhibits or disrupts the host shutoff of host translation, a host response that prevents mRNA in the cell to be translated, to prevent the symbiont from expressing its genes. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pg]" } } }, { "id": "GO:0160164", "name": "negative regulation of chromatin looping", "changes": { "name": { "current": "negative regulation of chromatin looping", "previous": "negative regulation of chromatin loopin" } } }, { "id": "GO:1901790", "name": "3-(2,3-dihydroxyphenyl)propanoate metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf]", "previous": "\"The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate.\" [GOC:TermGenie, GOC:yaf, MetaCyc:HCAMHPDEG-PWY]" } } }, { "id": "GO:1901807", "name": "capsanthin metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving capsanthin.\" [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]", "previous": "\"The chemical reactions and pathways involving capsanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]" } } }, { "id": "GO:1901808", "name": "capsanthin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of capsanthin.\" [GOC:TermGenie, GOC:yaf, PMID:10995282, UniPathway:UPA00806]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of capsanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806]" } } }, { "id": "GO:1901824", "name": "alpha-carotene biosynthetic process", "changes": { "name": { "current": "alpha-carotene biosynthetic process", "previous": "delta-carotene biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of alpha-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]", "previous": "\"The chemical reactions and pathways resulting in the formation of delta-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801]" }, "synonyms": { "current": [ "\"delta-carotene anabolism\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthesis\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthetic process\" EXACT []", "\"delta-carotene formation\" EXACT [GOC:TermGenie]", "\"delta-carotene synthesis\" EXACT [GOC:TermGenie]" ], "previous": [ "\"delta-carotene anabolism\" EXACT [GOC:TermGenie]", "\"delta-carotene biosynthesis\" EXACT [GOC:TermGenie]", "\"delta-carotene formation\" EXACT [GOC:TermGenie]", "\"delta-carotene synthesis\" EXACT [GOC:TermGenie]" ] } } }, { "id": "GO:1901833", "name": "neoxanthin biosynthetic process", "changes": { "name": { "current": "neoxanthin biosynthetic process", "previous": "all-trans-neoxanthin biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of trans-neoxanthin and 9'-cis-neoxanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]", "previous": "\"The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388]" }, "synonyms": { "current": [ "\"all-trans-neoxanthin anabolism\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthesis\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthetic process\" NARROW []", "\"all-trans-neoxanthin formation\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin synthesis\" EXACT [GOC:TermGenie]", "\"neoxanthin anabolism\" EXACT [GOC:yaf]", "\"neoxanthin biosynthesis\" EXACT [GOC:yaf]", "\"neoxanthin formation\" EXACT [GOC:yaf]", "\"neoxanthin synthesis\" EXACT [GOC:yaf]" ], "previous": [ "\"all-trans-neoxanthin anabolism\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin biosynthesis\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin formation\" EXACT [GOC:TermGenie]", "\"all-trans-neoxanthin synthesis\" EXACT [GOC:TermGenie]", "\"neoxanthin anabolism\" EXACT [GOC:yaf]", "\"neoxanthin biosynthesis\" EXACT [GOC:yaf]", "\"neoxanthin biosynthetic process\" EXACT [GOC:yaf]", "\"neoxanthin formation\" EXACT [GOC:yaf]", "\"neoxanthin synthesis\" EXACT [GOC:yaf]" ] } } }, { "id": "GO:1901864", "name": "capsorubin metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving capsorubin.\" [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]", "previous": "\"The chemical reactions and pathways involving capsorubin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]" } } }, { "id": "GO:1901865", "name": "capsorubin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of capsorubin.\" [GOC:TermGenie, GOC:yaf, UniPathway:UPA00807]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of capsorubin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807]" } } }, { "id": "GO:1902616", "name": "O-acyl-L-carnitine transmembrane transport", "changes": { "name": { "current": "O-acyl-L-carnitine transmembrane transport", "previous": "acyl carnitine transmembrane transport" }, "definition": { "current": "\"The process in which O-acyl-L-carnitine is transported across a membrane.\" [GO_REF:0000069, GOC:pr, GOC:TermGenie]", "previous": "\"The process in which acyl carnitine is transported across a membrane.\" [GO_REF:0000069, GOC:pr, GOC:TermGenie]" } } }, { "id": "GO:1904916", "name": "L-lysine transmembrane transport from lysosomal lumen to cytosol", "changes": { "name": { "current": "L-lysine transmembrane transport from lysosomal lumen to cytosol", "previous": "transmembrane L-lysine transport from lysosomal lumen to cytosol" }, "synonyms": { "current": [ "\"transmembrane L-lysine transport from lysosomal lumen to cytosol\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:1904918", "name": "L-histidine transmembrane transport from lysosomal lumen to cytosol", "changes": { "name": { "current": "L-histidine transmembrane transport from lysosomal lumen to cytosol", "previous": "transmembrane L-histidine transport from lysosomal lumen to cytosol" }, "synonyms": { "current": [ "\"transmembrane L-histidine transport from lysosomal lumen to cytosol\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:1904919", "name": "L-cystine transmembrane transport from lysosomal lumen to cytosol", "changes": { "name": { "current": "L-cystine transmembrane transport from lysosomal lumen to cytosol", "previous": "transmembrane L-cystine transport from lysosomal lumen to cytosol" }, "synonyms": { "current": [ "\"transmembrane L-cystine transport from lysosomal lumen to cytosol\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:1905554", "name": "negative regulation of blood vessel branching", "changes": { "name": { "current": "negative regulation of blood vessel branching", "previous": "negative regulation of vessel branching" } } }, { "id": "GO:1990217", "name": "symbiont-mediated suppression of host phytoalexin production", "changes": { "name": { "current": "symbiont-mediated suppression of host phytoalexin production", "previous": "suppression by symbiont of host phytoalexin production" }, "definition": { "current": "\"A process in which a symbiont inhibits or disrupts the production of phytoalexins in the host organism. Phytoalexins are produced by plants to fight against pathogens. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:21402357]", "previous": "\"Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:21402357]" }, "synonyms": { "current": [ "\"negative regulation by symbiont of host phytoalexin production\" EXACT []", "\"suppression by symbiont of host phytoalexin production\" EXACT []" ], "previous": [ "\"negative regulation by symbiont of host phytoalexin production\" EXACT []" ] } } }, { "id": "GO:2000322", "name": "regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "changes": { "name": { "current": "regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "previous": "regulation of glucocorticoid receptor signaling pathway" }, "definition": { "current": "\"Any process that modulates the frequency, rate or extent of nuclear receptor-mediated glucocorticoid signaling pathway.\" [GOC:BHF]", "previous": "\"Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway.\" [GOC:BHF]" }, "synonyms": { "current": [ "\"regulation of glucocorticoid receptor signaling pathway\" EXACT []", "\"regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ], "previous": [ "\"regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ] } } }, { "id": "GO:2000323", "name": "negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "changes": { "name": { "current": "negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "previous": "negative regulation of glucocorticoid receptor signaling pathway" }, "definition": { "current": "\"Any process that stops, prevents or reduces the frequency, rate or extent of nuclear receptor-mediated glucocorticoid signaling pathway.\" [GOC:BHF]", "previous": "\"Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.\" [GOC:BHF]" }, "synonyms": { "current": [ "\"negative regulation of glucocorticoid receptor signaling pathway\" EXACT []", "\"negative regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ], "previous": [ "\"negative regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ] } } }, { "id": "GO:2000324", "name": "positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "changes": { "name": { "current": "positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway", "previous": "positive regulation of glucocorticoid receptor signaling pathway" }, "definition": { "current": "\"Any process that activates or increases the frequency, rate or extent of nuclear receptor-mediated glucocorticoid signaling pathway.\" [GOC:BHF]", "previous": "\"Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway.\" [GOC:BHF]" }, "synonyms": { "current": [ "\"positive regulation of glucocorticoid receptor signaling pathway\" EXACT []", "\"positive regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ], "previous": [ "\"positive regulation of glucocorticoid receptor signalling pathway\" EXACT [GOC:obol]" ] } } } ], "molecular_function": [ { "id": "GO:0000246", "name": "Delta24(24-1) sterol reductase activity", "changes": { "name": { "current": "Delta24(24-1) sterol reductase activity", "previous": "delta24(24-1) sterol reductase activity" } } }, { "id": "GO:0000252", "name": "3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity", "changes": { "name": { "current": "3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity", "previous": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" }, "comment": { "current": "N/A", "previous": "Note that zymosterol is cholesta-8,24-dien-3-ol." }, "synonyms": { "current": [ "\"3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)\" RELATED [EC:1.1.1.170]", "\"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)\" EXACT []", "\"3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)\" RELATED []", "\"3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity\" RELATED []", "\"C-3 sterol dehydrogenase (C-4 decarboxylase) activity\" RELATED []", "\"C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity\" EXACT []", "\"C-3 sterol dehydrogenase activity\" RELATED []", "\"sterol 4alpha-carboxylic decarboxylase activity\" RELATED []", "\"sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity\" RELATED []", "\"sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\" RELATED []" ], "previous": [ "\"3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)\" RELATED [EC:1.1.1.170]", "\"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)\" EXACT []", "\"3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)\" RELATED []", "\"3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity\" RELATED []", "\"C-3 sterol dehydrogenase (C-4 decarboxylase) activity\" RELATED []", "\"C-3 sterol dehydrogenase activity\" RELATED []", "\"sterol 4alpha-carboxylic decarboxylase activity\" RELATED []", "\"sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity\" RELATED []", "\"sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\" RELATED []" ] } } }, { "id": "GO:0000253", "name": "3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "changes": { "name": { "current": "3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "previous": "3-keto sterol reductase activity" }, "comment": { "current": "N/A", "previous": "Note that zymosterol is cholesta-8,24-dien-3-ol." }, "synonyms": { "current": [ "\"3-keto sterol reductase activity\" EXACT []", "\"3-keto-steroid reductase activity\" EXACT []", "\"3-KSR activity\" RELATED [EC:1.1.1.270]", "\"3beta-hydroxy-steroid:NADP+ 3-oxidoreductase\" RELATED [EC:1.1.1.270]" ], "previous": [ "\"3-keto-steroid reductase activity\" EXACT []", "\"3-KSR activity\" RELATED [EC:1.1.1.270]", "\"3beta-hydroxy-steroid:NADP+ 3-oxidoreductase\" RELATED [EC:1.1.1.270]" ] } } }, { "id": "GO:0000254", "name": "C-4 methylsterol oxidase activity", "changes": { "comment": { "current": "N/A", "previous": "Note that zymosterol is cholesta-8,24-dien-3-ol." } } }, { "id": "GO:0001537", "name": "dermatan 4-sulfotransferase activity", "changes": { "name": { "current": "dermatan 4-sulfotransferase activity", "previous": "dermatan 4-sulfotransferase" } } }, { "id": "GO:0003707", "name": "nuclear steroid receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:14708019]", "previous": "\"Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.\" [GOC:signaling, PMID:14708019]" } } }, { "id": "GO:0003854", "name": "3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity", "changes": { "name": { "current": "3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity", "previous": "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity" } } }, { "id": "GO:0004111", "name": "creatine kinase activity", "changes": { "comment": { "current": "Note that this term has a MetaCyc pathway reference as the pathway only has a single step.", "previous": "N/A" } } }, { "id": "GO:0004161", "name": "dimethylallyltranstransferase activity", "changes": { "synonyms": { "current": [ "\"(2E,6E)-farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyltransferase activity\" EXACT []", "\"diprenyltransferase activity\" RELATED [EC:2.5.1.1]", "\"DMAPP:IPP-dimethylallyltransferase activity\" RELATED [EC:2.5.1.1]", "\"geranyl diphosphate synthase activity\" EXACT []", "\"geranyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"geranyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"geranyl-diphosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"trans-farnesyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]" ], "previous": [ "\"(2E,6E)-farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity\" RELATED [EC:2.5.1.1]", "\"dimethylallyltransferase activity\" EXACT []", "\"diprenyltransferase activity\" RELATED [EC:2.5.1.1]", "\"DMAPP:IPP-dimethylallyltransferase activity\" RELATED [EC:2.5.1.1]", "\"geranyl diphosphate synthase\" EXACT []", "\"geranyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"geranyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]", "\"geranyl-diphosphate synthase activity\" RELATED [EC:2.5.1.1]", "\"trans-farnesyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.1]" ] } } }, { "id": "GO:0004177", "name": "aminopeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.\" [EC:3.4.11.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]", "previous": "\"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.\" [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]" } } }, { "id": "GO:0004230", "name": "glutamyl aminopeptidase activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "glutamyl aminopeptidase activity", "previous": "obsolete glutamyl aminopeptidase activity" }, "definition": { "current": "\"Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.\" [EC:3.4.11.7]", "previous": "\"OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.\" [EC:3.4.11.7]" }, "comment": { "current": "N/A", "previous": "This term was made obsolete because it represents a gene product." }, "synonyms": { "current": [ "\"aminopeptidase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A2\" RELATED [EC:3.4.11.7]", "\"antigen BP-1/6C3 of mouse B lymphocytes\" RELATED [EC:3.4.11.7]", "\"aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"Ca2+-activated glutamate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"glutamyl peptidase activity\" RELATED [EC:3.4.11.7]", "\"L-aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"membrane aminopeptidase II\" RELATED [EC:3.4.11.7]" ], "previous": [ "\"aminopeptidase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A\" RELATED [EC:3.4.11.7]", "\"angiotensinase A2\" RELATED [EC:3.4.11.7]", "\"antigen BP-1/6C3 of mouse B lymphocytes\" RELATED [EC:3.4.11.7]", "\"aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"Ca2+-activated glutamate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"glutamyl aminopeptidase activity\" EXACT []", "\"glutamyl peptidase activity\" RELATED [EC:3.4.11.7]", "\"L-aspartate aminopeptidase activity\" RELATED [EC:3.4.11.7]", "\"membrane aminopeptidase II\" RELATED [EC:3.4.11.7]" ] } } }, { "id": "GO:0004311", "name": "geranylgeranyl diphosphate synthase activity", "changes": { "name": { "current": "geranylgeranyl diphosphate synthase activity", "previous": "farnesyltranstransferase activity" }, "synonyms": { "current": [ "\"farnesyltranstransferase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthetase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-diphosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-PP synthetase activity\" EXACT [EC:2.5.1.29]", "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]" ], "previous": [ "\"geranylgeranyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl pyrophosphate synthetase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-diphosphate synthase activity\" EXACT [EC:2.5.1.29]", "\"geranylgeranyl-PP synthetase activity\" EXACT [EC:2.5.1.29]", "\"trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" RELATED [EC:2.5.1.29]" ] } } }, { "id": "GO:0004337", "name": "(2E,6E)-farnesyl diphosphate synthase activity", "changes": { "name": { "current": "(2E,6E)-farnesyl diphosphate synthase activity", "previous": "geranyltranstransferase activity" }, "synonyms": { "current": [ "\"farnesyl diphosphate synthase activity\" EXACT []", "\"farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"farnesyl pyrophosphate synthetase activity\" EXACT []", "\"farnesyl-diphosphate synthase activity\" EXACT []", "\"farnesylpyrophosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"FPP synthetase activity\" RELATED [EC:2.5.1.10]", "\"geranyl transferase I\" RELATED [EC:2.5.1.10]", "\"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltranstransferase activity\" EXACT [EC:2.5.1.10]" ], "previous": [ "\"farnesyl diphosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"farnesyl pyrophosphate synthetase activity\" EXACT []", "\"farnesyl-diphosphate synthase activity\" EXACT []", "\"farnesylpyrophosphate synthetase activity\" RELATED [EC:2.5.1.10]", "\"FPP synthetase activity\" RELATED [EC:2.5.1.10]", "\"geranyl transferase I\" RELATED [EC:2.5.1.10]", "\"geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity\" RELATED [EC:2.5.1.10]", "\"geranyltransferase activity\" RELATED [EC:2.5.1.10]" ] } } }, { "id": "GO:0004394", "name": "heparan sulfate 2-sulfotransferase activity", "changes": { "name": { "current": "heparan sulfate 2-sulfotransferase activity", "previous": "heparan sulfate 2-O-sulfotransferase activity" }, "synonyms": { "current": [ "\"heparan sulfate 2-O-sulfotransferase activity\" EXACT []", "\"heparan-sulfate 2-O-sulphotransferase activity\" EXACT []", "\"heparin 2-sulfotransferase activity\" RELATED []", "\"heparin-sulphate 2-sulphotransferase activity\" RELATED []" ], "previous": [ "\"heparan-sulfate 2-O-sulphotransferase activity\" EXACT []", "\"heparin 2-sulfotransferase activity\" RELATED []", "\"heparin-sulphate 2-sulphotransferase activity\" RELATED []" ] } } }, { "id": "GO:0004619", "name": "phosphoglycerate mutase activity", "changes": { "synonyms": { "current": [ "\"2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity\" NARROW []", "\"2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity\" NARROW []", "\"D-phosphoglycerate 2,3-phosphomutase activity\" RELATED []", "\"PGA mutase activity\" RELATED []", "\"PGAM activity\" RELATED []", "\"PGM\" EXACT []", "\"phosphoglycerate phosphomutase activity\" RELATED []", "\"phosphoglyceromutase activity\" RELATED []" ], "previous": [ "\"D-phosphoglycerate 2,3-phosphomutase activity\" RELATED []", "\"PGA mutase activity\" RELATED []", "\"PGAM activity\" RELATED []", "\"PGM\" EXACT []", "\"phosphoglycerate phosphomutase activity\" RELATED []", "\"phosphoglyceromutase activity\" RELATED []" ] } } }, { "id": "GO:0004769", "name": "steroid Delta-isomerase activity", "changes": { "name": { "current": "steroid Delta-isomerase activity", "previous": "steroid delta-isomerase activity" } } }, { "id": "GO:0004779", "name": "sulfate adenylyltransferase activity", "changes": { "definition": { "current": "\"Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.\" [GOC:mah]", "previous": "\"Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate.\" [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]" } } }, { "id": "GO:0004883", "name": "nuclear glucocorticoid receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by glucocorticoid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:17689856, PMID:20920967]", "previous": "\"Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.\" [GOC:signaling, PMID:17689856, PMID:20920967]" } } }, { "id": "GO:0005125", "name": "cytokine activity", "changes": { "synonyms": { "current": [ "\"autocrine activity\" RELATED [GOC:rl]", "\"paracrine activity\" RELATED [GOC:rl]", "\"phytocytokine activity\" NARROW [PMID:23072994]" ], "previous": [ "\"autocrine activity\" RELATED [GOC:rl]", "\"paracrine activity\" RELATED [GOC:rl]" ] } } }, { "id": "GO:0005461", "name": "UDP-glucuronate transmembrane transporter activity", "changes": { "name": { "current": "UDP-glucuronate transmembrane transporter activity", "previous": "UDP-glucuronic acid transmembrane transporter activity" }, "synonyms": { "current": [ "\"UDP-glucuronic acid transmembrane transporter activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0005476", "name": "carnitine:O-acyl-L-carnitine antiporter activity", "changes": { "name": { "current": "carnitine:O-acyl-L-carnitine antiporter activity", "previous": "carnitine:acyl carnitine antiporter activity" } } }, { "id": "GO:0008146", "name": "sulfotransferase activity", "changes": { "definition": { "current": "\"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.\" [EC:2.8.2.-]", "previous": "\"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.\" [GOC:curators]" } } }, { "id": "GO:0008233", "name": "peptidase activity", "changes": { "definition": { "current": "\"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.\" [EC:3.4.-.-, GOC:jl]", "previous": "\"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.\" [GOC:jl, ISBN:0815332181]" } } }, { "id": "GO:0008241", "name": "peptidyl-dipeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the release of C-terminal dipeptides from a polypeptide chain.\" [EC:3.4.15.-, GOC:mb]", "previous": "\"Catalysis of the release of C-terminal dipeptides from a polypeptide chain.\" [GOC:mb]" } } }, { "id": "GO:0008395", "name": "steroid hydroxylase activity", "changes": { "synonyms": { "current": [ "\"cytochrome P450 CYP2G1\" NARROW []", "\"olfactory-specific steroid hydroxylase activity\" NARROW []", "\"steroid monooxygenase activity\" EXACT []" ], "previous": [ "\"cytochrome P450 CYP2G1\" NARROW []", "\"olfactory-specific steroid hydroxylase activity\" NARROW []" ] } } }, { "id": "GO:0008412", "name": "4-hydroxybenzoate polyprenyltransferase activity", "changes": { "synonyms": { "current": [ "\"4-HB polyprenyltransferase activity\" EXACT []", "\"4-hydroxybenzoate nonaprenyltransferase activity\" NARROW [EC:2.5.1.39]", "\"para-hydroxybenzoate transferase activity\" EXACT []", "\"para-hydroxybenzoate-polyprenyl diphosphate transferase activity\" EXACT []", "\"para-hydroxybenzoate:polyprenyltransferase activity\" EXACT []", "\"PHB polyprenyl diphosphate transferase activity\" EXACT []" ], "previous": [ "\"4-HB polyprenyltransferase activity\" EXACT []", "\"para-hydroxybenzoate transferase activity\" EXACT []", "\"para-hydroxybenzoate-polyprenyl diphosphate transferase activity\" EXACT []", "\"para-hydroxybenzoate:polyprenyltransferase activity\" EXACT []", "\"PHB polyprenyl diphosphate transferase activity\" EXACT []" ] } } }, { "id": "GO:0008425", "name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "changes": { "name": { "current": "2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "previous": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" }, "synonyms": { "current": [ "\"2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity\" EXACT []", "\"2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity\" EXACT []", "\"coenzyme Q biosynthesis methyltransferase activity\" EXACT []", "\"coenzyme Q biosynthetic process methyltransferase activity\" EXACT []", "\"ubiquinone biosynthesis methyltransferase activity\" BROAD []", "\"ubiquinone biosynthetic process methyltransferase activity\" BROAD []" ], "previous": [ "\"2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity\" EXACT []", "\"coenzyme Q biosynthesis methyltransferase activity\" EXACT []", "\"coenzyme Q biosynthetic process methyltransferase activity\" EXACT []", "\"ubiquinone biosynthesis methyltransferase activity\" BROAD []", "\"ubiquinone biosynthetic process methyltransferase activity\" BROAD []" ] } } }, { "id": "GO:0008467", "name": "[heparan sulfate]-glucosamine 3-sulfotransferase activity", "changes": { "name": { "current": "[heparan sulfate]-glucosamine 3-sulfotransferase activity", "previous": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity" }, "synonyms": { "current": [ "\"3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase\" BROAD []", "\"3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity\" RELATED []", "\"3-OST activity\" RELATED []", "\"[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity\" NARROW []", "\"[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity\" NARROW []", "\"[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity\" NARROW []", "\"glucosaminyl 3-O-sulfotransferase activity\" RELATED []", "\"heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity\" RELATED []", "\"heparin-glucosamine 3-O-sulfotransferase activity\" RELATED []", "\"heparin-glucosamine 3-O-sulphotransferase activity\" RELATED []" ], "previous": [ "\"3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase\" BROAD [EC:2.8.2.23]", "\"3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity\" RELATED [EC:2.8.2.23]", "\"3-OST-1 activity\" RELATED [EC:2.8.2.23]", "\"glucosaminyl 3-O-sulfotransferase activity\" RELATED [EC:2.8.2.23]", "\"heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity\" RELATED [EC:2.8.2.23]", "\"heparin-glucosamine 3-O-sulfotransferase activity\" RELATED []", "\"heparin-glucosamine 3-O-sulphotransferase activity\" RELATED []", "\"isoform/isozyme 1 (3-OST-1, HS3ST1)\" RELATED [EC:2.8.2.23]" ] } } }, { "id": "GO:0008709", "name": "cholate 7-alpha-dehydrogenase (NAD+) activity", "changes": { "name": { "current": "cholate 7-alpha-dehydrogenase (NAD+) activity", "previous": "cholate 7-alpha-dehydrogenase activity" } } }, { "id": "GO:0008834", "name": "ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity", "changes": { "name": { "current": "ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity", "previous": "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" }, "synonyms": { "current": [ "\"bactoprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenylcistransferase activity\" EXACT []", "\"di-trans,poly-cis-undecaprenyl-diphosphate synthase activity\" EXACT [EC:2.5.1.31]", "\"undecaprenyl diphosphate synthase activity\" EXACT []", "\"undecaprenyl diphosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"UPP synthetase activity\" RELATED [EC:2.5.1.31]" ], "previous": [ "\"bactoprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity\" RELATED [EC:2.5.1.31]", "\"di-trans,poly-cis-decaprenylcistransferase activity\" EXACT []", "\"undecaprenyl diphosphate synthase activity\" EXACT []", "\"undecaprenyl diphosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl pyrophosphate synthetase activity\" RELATED [EC:2.5.1.31]", "\"undecaprenyl-diphosphate synthase activity\" RELATED [EC:2.5.1.31]", "\"UPP synthetase activity\" RELATED [EC:2.5.1.31]" ] } } }, { "id": "GO:0008970", "name": "phospholipase A1 activity", "changes": { "synonyms": { "current": [ "\"phosphatidylcholine 1-acylhydrolase activity\" EXACT []", "\"phosphatidylserine 1-acylhydrolase activity\" NARROW []" ], "previous": [ "\"phosphatidylcholine 1-acylhydrolase activity\" EXACT []" ] } } }, { "id": "GO:0010176", "name": "homogentisate phytyltransferase activity", "changes": { "synonyms": { "current": [ "\"HPT activity\" EXACT [EC:2.5.1.115]" ], "previous": "N/A" } } }, { "id": "GO:0010291", "name": "beta-carotene 3-hydroxylase activity", "changes": { "name": { "current": "beta-carotene 3-hydroxylase activity", "previous": "carotene beta-ring hydroxylase activity" }, "synonyms": { "current": [ "\"beta-carotene hydroxylase activity\" NARROW []", "\"carotene beta-ring hydroxylase activity\" RELATED []" ], "previous": [ "\"beta-carotene hydroxylase activity\" NARROW []" ] } } }, { "id": "GO:0010356", "name": "homogentisate geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"HGGT activity\" EXACT [EC:2.5.1.116]", "\"homogentisate geranylgeranyl transferase activity\" EXACT [PMID:21223386]" ], "previous": [ "\"homogentisate geranylgeranyl transferase activity\" EXACT [PMID:21223386]" ] } } }, { "id": "GO:0010357", "name": "homogentisate solanesyltransferase activity", "changes": { "synonyms": { "current": [ "\"homogentisate solanyltransferase activity\" EXACT []", "\"HST activity\" EXACT [EC:2.5.1.117]" ], "previous": [ "\"homogentisate solanyltransferase activity\" EXACT []" ] } } }, { "id": "GO:0010420", "name": "polyprenyldihydroxybenzoate methyltransferase activity", "changes": { "name": { "current": "polyprenyldihydroxybenzoate methyltransferase activity", "previous": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity" }, "synonyms": { "current": [ "\"3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity\" EXACT [EC:2.1.1.114]" ], "previous": [ "\"polyprenyldihydroxybenzoate methyltransferase activity\" RELATED []" ] } } }, { "id": "GO:0015016", "name": "heparan sulfate N-sulfotransferase activity", "changes": { "name": { "current": "heparan sulfate N-sulfotransferase activity", "previous": "[heparan sulfate]-glucosamine N-sulfotransferase activity" }, "synonyms": { "current": [ "\"3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"[heparan sulfate]-glucosamine N-sulfotransferase activity\" EXACT []", "\"[heparan sulphate]-glucosamine N-sulphotransferase activity\" EXACT []", "\"desulfoheparin sulfotransferase activity\" EXACT []", "\"glucosaminyl N-deacetylase/N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparan sulfate 2-N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparan sulfate N-deacetylase/N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparin N-deacetylase/N-sulfotransferase activity\" RELATED []", "\"heparin N-deacetylase/N-sulphotransferase activity\" RELATED []", "\"heparin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparin-glucosamine N-sulfotransferase activity\" EXACT []", "\"heparitin N-sulfotransferase activity\" EXACT []", "\"heparitin N-sulphotransferase activity\" EXACT []", "\"heparitin sulfotransferase activity\" EXACT []", "\"N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"N-heparan sulfate sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"N-HSST activity\" RELATED [EC:2.8.2.8]", "\"PAPS:DSH sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"PAPS:N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]" ], "previous": [ "\"3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"[heparan sulphate]-glucosamine N-sulphotransferase activity\" EXACT []", "\"desulfoheparin sulfotransferase activity\" EXACT []", "\"glucosaminyl N-deacetylase/N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparan sulfate 2-N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparan sulfate N-deacetylase/N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparan sulfate N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparin N-deacetylase/N-sulfotransferase activity\" RELATED []", "\"heparin N-deacetylase/N-sulphotransferase activity\" RELATED []", "\"heparin N-sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"heparin-glucosamine N-sulfotransferase activity\" EXACT []", "\"heparitin N-sulfotransferase activity\" EXACT []", "\"heparitin N-sulphotransferase activity\" EXACT []", "\"heparitin sulfotransferase activity\" EXACT []", "\"N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"N-heparan sulfate sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"N-HSST activity\" RELATED [EC:2.8.2.8]", "\"PAPS:DSH sulfotransferase activity\" RELATED [EC:2.8.2.8]", "\"PAPS:N-desulfoheparin sulfotransferase activity\" RELATED [EC:2.8.2.8]" ] } } }, { "id": "GO:0015227", "name": "O-acyl-L-carnitine transmembrane transporter activity", "changes": { "name": { "current": "O-acyl-L-carnitine transmembrane transporter activity", "previous": "acyl carnitine transmembrane transporter activity" }, "definition": { "current": "\"Enables the transfer of O-acyl-L-carnitine from one side of a membrane to the other. O-acyl-L-carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane.\" [GOC:ai]", "previous": "\"Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane.\" [GOC:ai]" } } }, { "id": "GO:0015280", "name": "ligand-gated sodium channel activity", "changes": { "synonyms": { "current": [ "\"acid-sensing ion channel activity\" NARROW [GOC:fj]", "\"epithelial sodium channel\" NARROW [GOC:fj]" ], "previous": [ "\"acid-sensing ion channel activity\" NARROW [GOC:fj]", "\"amiloride-sensitive sodium channel activity\" NARROW [GOC:fj]", "\"ASIC activity\" NARROW [GOC:fj]", "\"epithelial sodium channel\" NARROW [GOC:fj]" ] } } }, { "id": "GO:0016172", "name": "antifreeze activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "antifreeze activity", "previous": "obsolete antifreeze activity" }, "definition": { "current": "\"Inhibits the growth and recrystallization of ice crystals, thereby lowering the freezing point of water and preventing cellular damage at subzero temperatures. This activity is observed in various cold-adapted organisms, including certain fish, insects, and plants, and contributes to survival in extreme cold environments by stabilizing supercooled liquid states.\" [GOC:cjm, PMID:33317024]", "previous": "\"OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures.\" [GOC:jl]" }, "comment": { "current": "Note that this term was reinstated from obsolete.", "previous": "This term was made obsolete because it refers to a biological process." }, "synonyms": { "current": "N/A", "previous": [ "\"antifreeze activity\" EXACT []" ] } } }, { "id": "GO:0016285", "name": "alanyl aminopeptidase activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "alanyl aminopeptidase activity", "previous": "obsolete cytosol alanyl aminopeptidase activity" }, "definition": { "current": "\"Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.\" [EC:3.4.11.14]", "previous": "\"OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.\" [EC:3.4.11.14]" }, "comment": { "current": "N/A", "previous": "This term was made obsolete because it represents a gene product and refers to cellular component information." }, "synonyms": { "current": [ "\"aminopolypeptidase activity\" BROAD [EC:3.4.11.14]", "\"arylamidase activity\" NARROW [EC:3.4.11.14]", "\"cytosol alanyl aminopeptidase activity\" EXACT []", "\"cytosol aminopeptidase III activity\" NARROW [EC:3.4.11.14]", "\"human liver aminopeptidase\" NARROW [EC:3.4.11.14]", "\"liver aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"membrane alanine aminopeptidase\" NARROW []", "\"membrane alanyl aminopeptidase\" NARROW []", "\"puromycin-sensitive aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"soluble alanyl aminopeptidase activity\" RELATED [EC:3.4.11.14]", "\"thiol-activated aminopeptidase activity\" RELATED [EC:3.4.11.14]" ], "previous": [ "\"aminopolypeptidase activity\" RELATED [EC:3.4.11.14]", "\"arylamidase activity\" NARROW [EC:3.4.11.14]", "\"cytosol alanyl aminopeptidase activity\" EXACT []", "\"cytosol aminopeptidase III activity\" NARROW [EC:3.4.11.14]", "\"human liver aminopeptidase\" NARROW [EC:3.4.11.14]", "\"liver aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"puromycin-sensitive aminopeptidase activity\" NARROW [EC:3.4.11.14]", "\"soluble alanyl aminopeptidase activity\" RELATED [EC:3.4.11.14]", "\"thiol-activated aminopeptidase activity\" RELATED [EC:3.4.11.14]" ] } } }, { "id": "GO:0016664", "name": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "changes": { "definition": { "current": "\"Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein.\" [EC:1.7.7.-]", "previous": "\"Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein.\" [GOC:jl]" } } }, { "id": "GO:0016805", "name": "dipeptidase activity", "changes": { "definition": { "current": "\"Catalysis of the hydrolysis of a dipeptide.\" [EC:3.4.13.-, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]", "previous": "\"Catalysis of the hydrolysis of a dipeptide.\" [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]" } } }, { "id": "GO:0016857", "name": "racemase and epimerase activity, acting on carbohydrates and derivatives", "changes": { "definition": { "current": "\"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.\" [EC:5.1.3.-, GOC:mah]", "previous": "\"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.\" [GOC:mah]" } } }, { "id": "GO:0016861", "name": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "changes": { "definition": { "current": "\"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.\" [EC:5.3.1.-, GOC:jl]", "previous": "\"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.\" [GOC:jl]" } } }, { "id": "GO:0016862", "name": "intramolecular oxidoreductase activity, interconverting keto- and enol-groups", "changes": { "definition": { "current": "\"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears.\" [EC:5.3.2.-, GOC:jl]", "previous": "\"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears.\" [GOC:jl]" } } }, { "id": "GO:0017095", "name": "heparan sulfate 6-sulfotransferase activity", "changes": { "name": { "current": "heparan sulfate 6-sulfotransferase activity", "previous": "heparan sulfate 6-O-sulfotransferase activity" }, "synonyms": { "current": [ "\"heparan sulfate 6-O-sulfotransferase activity\" EXACT []", "\"heparan sulphate 6-O-sulphotransferase activity\" EXACT []", "\"heparin 6-O-sulfotransferase activity\" RELATED []" ], "previous": [ "\"heparan sulphate 6-O-sulphotransferase activity\" EXACT []", "\"heparin 6-O-sulfotransferase activity\" RELATED []" ] } } }, { "id": "GO:0019833", "name": "ice nucleation activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "ice nucleation activity", "previous": "obsolete ice nucleation activity" }, "definition": { "current": "\"Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees Celsius) to protect the organism from damage by intracellular ice formation. This process is commonly found in certain bacteria, such as Pseudomonas syringae, and plays roles in environmental adaptation and plant pathogenesis.\" [GOC:cjm, PMID:35551271, UniProt:KW-0387]", "previous": "\"OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins" }, "comment": { "current": "Note that this term was reinstated from obsolete.", "previous": "This term was made obsolete because it represents a biological process." }, "synonyms": { "current": "N/A", "previous": [ "\"ice nucleation activity\" EXACT []" ] } } }, { "id": "GO:0030284", "name": "nuclear estrogen receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by estrogen binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:signaling, PMID:17615392]", "previous": "\"Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.\" [GOC:signaling, PMID:17615392]" } } }, { "id": "GO:0030378", "name": "serine racemase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Catalysis of the synthesis of free D-serine from L-serine.\" [GOC:kd]" } } }, { "id": "GO:0030674", "name": "protein-macromolecule adaptor activity", "changes": { "definition": { "current": "\"An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.\" [GOC:bf, GOC:mah, GOC:vw]", "previous": "\"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.\" [GOC:bf, GOC:mah, GOC:vw]" } } }, { "id": "GO:0031963", "name": "nuclear cortisol receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by cortisol binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [GOC:mah, PMID:12511169]", "previous": "\"Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.\" [GOC:mah, PMID:12511169]" } } }, { "id": "GO:0033703", "name": "3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity", "changes": { "name": { "current": "3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity", "previous": "3beta-hydroxy-5beta-steroid dehydrogenase activity" } } }, { "id": "GO:0033704", "name": "3-beta-hydroxy-5-alpha-steroid dehydrogenase (NADP+) activity", "changes": { "name": { "current": "3-beta-hydroxy-5-alpha-steroid dehydrogenase (NADP+) activity", "previous": "3beta-hydroxy-5alpha-steroid dehydrogenase activity" } } }, { "id": "GO:0033782", "name": "24S-hydroxycholesterol 7-alpha-hydroxylase activity", "changes": { "name": { "current": "24S-hydroxycholesterol 7-alpha-hydroxylase activity", "previous": "24-hydroxycholesterol 7alpha-hydroxylase activity" }, "synonyms": { "current": [ "\"24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity\" RELATED []", "\"24-hydroxycholesterol 7alpha-hydroxylase activity\" BROAD []", "\"24-hydroxycholesterol 7alpha-monooxygenase activity\" RELATED [EC:1.14.14.26]" ], "previous": [ "\"24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity\" RELATED []", "\"24-hydroxycholesterol 7alpha-monooxygenase activity\" RELATED [EC:1.14.14.26]" ] } } }, { "id": "GO:0033783", "name": "25-hydroxycholesterol 7-alpha-hydroxylase activity", "changes": { "name": { "current": "25-hydroxycholesterol 7-alpha-hydroxylase activity", "previous": "25-hydroxycholesterol 7alpha-hydroxylase activity" } } }, { "id": "GO:0033842", "name": "N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity", "changes": { "name": { "current": "N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity", "previous": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity" }, "synonyms": { "current": [ "\"beta1,4-N-acetylgalactosaminyltransferase activity\" RELATED [EC:2.4.1.244]", "\"beta1,4-N-acetylgalactosaminyltransferase III activity\" RELATED [EC:2.4.1.244]", "\"beta1,4-N-acetylgalactosaminyltransferase IV activity\" RELATED [EC:2.4.1.244]", "\"beta4GalNAc-T3\" RELATED [EC:2.4.1.244]", "\"beta4GalNAc-T4\" RELATED [EC:2.4.1.244]", "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity\" EXACT [EC:2.4.1.244]", "\"UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity\" RELATED [EC:2.4.1.244]" ], "previous": [ "\"beta1,4-N-acetylgalactosaminyltransferase activity\" RELATED [EC:2.4.1.244]", "\"beta1,4-N-acetylgalactosaminyltransferase III activity\" RELATED [EC:2.4.1.244]", "\"beta1,4-N-acetylgalactosaminyltransferase IV activity\" RELATED [EC:2.4.1.244]", "\"beta4GalNAc-T3\" RELATED [EC:2.4.1.244]", "\"beta4GalNAc-T4\" RELATED [EC:2.4.1.244]", "\"UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity\" RELATED [EC:2.4.1.244]" ] } } }, { "id": "GO:0034482", "name": "chondroitin 2-sulfotransferase activity", "changes": { "name": { "current": "chondroitin 2-sulfotransferase activity", "previous": "chondroitin 2-O-sulfotransferase activity" }, "synonyms": { "current": [ "\"chondroitin 2-O-sulfotransferase activity\" EXACT []", "\"chondroitin 2-O-sulphotransferase activity\" EXACT []" ], "previous": [ "\"chondroitin 2-O-sulphotransferase activity\" EXACT []", "\"chondroitin 2-sulfotransferase activity\" EXACT []" ] } } }, { "id": "GO:0035302", "name": "ecdysteroid 25-hydroxylase activity", "changes": { "definition": { "current": "\"Catalysis of the hydroxylation of an ecdysteroid at carbon position 25.\" [PMID:15350618]", "previous": "\"Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods.\" [ISBN:0198506732, PMID:15350618]" } } }, { "id": "GO:0036185", "name": "13-lipoxin reductase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Definition" } } }, { "id": "GO:0036423", "name": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "changes": { "synonyms": { "current": [ "\"hexaprenyl diphosphate synthase activity\" BROAD [EC:2.5.1.83]", "\"hexaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.83]", "\"HexPS activity\" EXACT [EC:2.5.1.83]" ], "previous": [ "\"hexaprenyl diphosphate synthase activity\" BROAD [EC:2.5.1.83]", "\"hexaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.83]" ] } } }, { "id": "GO:0038186", "name": "bile acid nuclear receptor activity", "changes": { "definition": { "current": "\"A nuclear receptor activity regulated by a bile acid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.\" [PMID:32480317, PMID:35415765, PMID:36409000]", "previous": "\"A DNA-binding transcription factor activity regulated by binding to a bile acid that modulates the transcription of specific gene sets transcribed by RNA polymerase II.\" [PMID:32480317, PMID:35415765, PMID:36409000]" } } }, { "id": "GO:0042409", "name": "caffeoyl-CoA O-methyltransferase activity", "changes": { "synonyms": { "current": [ "\"caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity\" EXACT []", "\"caffeoyl coenzyme A methyltransferase activity\" EXACT []", "\"caffeoyl-CoA 3-O-methyltransferase activity\" EXACT []", "\"S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity\" RELATED [EC:2.1.1.104]", "\"trans-caffeoyl-CoA 3-O-methyltransferase activity\" RELATED [EC:2.1.1.104]" ], "previous": [ "\"caffeoyl coenzyme A methyltransferase activity\" EXACT []", "\"caffeoyl-CoA 3-O-methyltransferase activity\" EXACT []", "\"S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity\" RELATED [EC:2.1.1.104]", "\"trans-caffeoyl-CoA 3-O-methyltransferase activity\" RELATED [EC:2.1.1.104]" ] } } }, { "id": "GO:0042767", "name": "ecdysteroid 22-hydroxylase activity", "changes": { "synonyms": { "current": [ "\"3-dehydro-2,22-dideoxyecdysone 22-hydroxylase activity\" NARROW [EC:1.14.15.44]" ], "previous": "N/A" } } }, { "id": "GO:0042768", "name": "ecdysteroid 2-hydroxylase activity", "changes": { "definition": { "current": "\"Catalysis of the hydroxylation of an ecdysteroid at carbon position 2.\" [PMID:12177427]", "previous": "\"Catalysis of the reaction" } } }, { "id": "GO:0044687", "name": "geranylfarnesyl diphosphate synthase activity", "changes": { "synonyms": { "current": [ "\"FGPP synthase activity\" EXACT [EC:2.5.1.81]" ], "previous": "N/A" } } }, { "id": "GO:0045547", "name": "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "changes": { "name": { "current": "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "previous": "dehydrodolichyl diphosphate synthase activity" }, "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate.\" [PMID:9858571]" }, "synonyms": { "current": [ "\"dehydrodolichyl diphosphate synthase activity\" EXACT [EC:2.5.1.87]" ], "previous": "N/A" } } }, { "id": "GO:0046562", "name": "beta-D-glucose oxidase activity", "changes": { "name": { "current": "beta-D-glucose oxidase activity", "previous": "glucose oxidase activity" }, "synonyms": { "current": [ "\"beta-D-glucose:oxygen 1-oxido-reductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:oxygen 1-oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:quinone oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"corylophyline\" RELATED [EC:1.1.3.4]", "\"D-glucose oxidase activity\" RELATED [EC:1.1.3.4]", "\"D-glucose-1-oxidase activity\" RELATED [EC:1.1.3.4]", "\"deoxin-1\" RELATED [EC:1.1.3.4]", "\"glucose aerodehydrogenase activity\" RELATED [EC:1.1.3.4]", "\"glucose oxidase activity\" EXACT []", "\"glucose oxyhydrase activity\" RELATED [EC:1.1.3.4]", "\"GOD activity\" RELATED [EC:1.1.3.4]", "\"microcid\" RELATED [EC:1.1.3.4]", "\"penatin\" RELATED [EC:1.1.3.4]" ], "previous": [ "\"beta-D-glucose oxidase activity\" EXACT []", "\"beta-D-glucose:oxygen 1-oxido-reductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:oxygen 1-oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"beta-D-glucose:quinone oxidoreductase activity\" RELATED [EC:1.1.3.4]", "\"corylophyline\" RELATED [EC:1.1.3.4]", "\"D-glucose oxidase activity\" RELATED [EC:1.1.3.4]", "\"D-glucose-1-oxidase activity\" RELATED [EC:1.1.3.4]", "\"deoxin-1\" RELATED [EC:1.1.3.4]", "\"glucose aerodehydrogenase activity\" RELATED [EC:1.1.3.4]", "\"glucose oxyhydrase activity\" RELATED [EC:1.1.3.4]", "\"GOD activity\" RELATED [EC:1.1.3.4]", "\"microcid\" RELATED [EC:1.1.3.4]", "\"penatin\" RELATED [EC:1.1.3.4]" ] } } }, { "id": "GO:0046905", "name": "15-cis-phytoene synthase activity", "changes": { "comment": { "current": "N/A", "previous": "Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32." }, "synonyms": { "current": [ "\"geranylgeranyl-diphosphate geranylgeranyltransferase activity\" EXACT [EC:2.5.1.32]", "\"geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (15-cis-phytoene-forming) activity\" EXACT [EC:2.5.1.32]", "\"phytoene synthase activity\" EXACT [EC:2.5.1.32]", "\"prephytoene-diphosphate synthase activity\" EXACT [EC:2.5.1.32]", "\"PSase activity\" EXACT [EC:2.5.1.32]" ], "previous": [ "\"phytoene synthase activity\" BROAD []" ] } } }, { "id": "GO:0047005", "name": "16-alpha-hydroxysteroid dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "16-alpha-hydroxysteroid dehydrogenase [NAD(P)+] activity", "previous": "16-alpha-hydroxysteroid dehydrogenase (NADP+) activity" } } }, { "id": "GO:0047006", "name": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity", "previous": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity" }, "synonyms": { "current": [ "\"17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity\" EXACT []", "\"20alpha-HSD\" RELATED [EC:1.1.1.149]", "\"20alpha-HSDH\" RELATED [EC:1.1.1.149]", "\"20alpha-hydroxy steroid dehydrogenase activity\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid dehydrogenase\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity\" BROAD [EC:1.1.1.149]" ], "previous": [ "\"20alpha-HSD\" RELATED [EC:1.1.1.149]", "\"20alpha-HSDH\" RELATED [EC:1.1.1.149]", "\"20alpha-hydroxy steroid dehydrogenase activity\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid dehydrogenase\" BROAD [EC:1.1.1.149]", "\"20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity\" BROAD [EC:1.1.1.149]" ] } } }, { "id": "GO:0047013", "name": "cholate 12-alpha dehydrogenase (NADP+) activity", "changes": { "name": { "current": "cholate 12-alpha dehydrogenase (NADP+) activity", "previous": "cholate 12-alpha dehydrogenase activity" } } }, { "id": "GO:0047023", "name": "androsterone dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "androsterone dehydrogenase [NAD(P)+] activity", "previous": "androsterone dehydrogenase activity" } } }, { "id": "GO:0047024", "name": "5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity", "changes": { "name": { "current": "5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity", "previous": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity" }, "synonyms": { "current": [ "\"3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3-beta-HSD activity\" RELATED [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"3beta,20alpha-hydroxysteroid oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"5alpha-androstane-3beta,17beta-diol dehydrogenase activity\" EXACT []", "\"dehydrogenase, 3beta,20alpha-hydroxy steroid\" BROAD [EC:1.1.1.210]", "\"progesterone reductase activity\" RELATED [EC:1.1.1.210]" ], "previous": [ "\"3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3-beta-HSD activity\" RELATED [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.210]", "\"3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"3beta,20alpha-hydroxysteroid oxidoreductase activity\" BROAD [EC:1.1.1.210]", "\"dehydrogenase, 3beta,20alpha-hydroxy steroid\" BROAD [EC:1.1.1.210]", "\"progesterone reductase activity\" RELATED [EC:1.1.1.210]" ] } } }, { "id": "GO:0047044", "name": "androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "changes": { "name": { "current": "androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "previous": "androstan-3-alpha,17-beta-diol dehydrogenase activity" } } }, { "id": "GO:0047294", "name": "phosphoglycerol geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"(S)-3-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]", "\"geranylgeranyl-transferase activity\" RELATED [EC:2.5.1.41]", "\"GGGP synthase activity\" EXACT [EC:2.5.1.41]", "\"GGGPS activity\" EXACT [EC:2.5.1.41]", "\"glycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]" ], "previous": [ "\"(S)-3-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]", "\"geranylgeranyl-transferase activity\" RELATED [EC:2.5.1.41]", "\"glycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.41]" ] } } }, { "id": "GO:0047295", "name": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "changes": { "synonyms": { "current": [ "\"(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"DGGGP synthase activity\" EXACT [EC:2.5.1.42]", "\"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyltransferase II\" RELATED [EC:2.5.1.42]" ], "previous": [ "\"(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity\" EXACT []", "\"geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity\" RELATED [EC:2.5.1.42]", "\"geranylgeranyltransferase II\" RELATED [EC:2.5.1.42]" ] } } }, { "id": "GO:0047521", "name": "12-beta-hydroxysteroid dehydrogenase (NADP+) activity", "changes": { "name": { "current": "12-beta-hydroxysteroid dehydrogenase (NADP+) activity", "previous": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity" }, "synonyms": { "current": [ "\"12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity\" BROAD [EC:1.1.1.238]", "\"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity\" BROAD [EC:1.1.1.238]" ], "previous": [ "\"12-beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid dehydrogenase activity\" BROAD [EC:1.1.1.238]", "\"12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity\" BROAD [EC:1.1.1.238]" ] } } }, { "id": "GO:0047751", "name": "3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "changes": { "name": { "current": "3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "previous": "3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity" } } }, { "id": "GO:0047791", "name": "cucurbitacin Delta23 reductase [NAD(P)H] activity", "changes": { "name": { "current": "cucurbitacin Delta23 reductase [NAD(P)H] activity", "previous": "cucurbitacin delta23-reductase activity" } } }, { "id": "GO:0050497", "name": "alkylthioltransferase activity", "changes": { "definition": { "current": "\"Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor).\" [EC:2.8.4.-, GOC:ai]", "previous": "\"Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor).\" [GOC:ai]" } } }, { "id": "GO:0050613", "name": "Delta14-sterol reductase activity", "changes": { "name": { "current": "Delta14-sterol reductase activity", "previous": "delta14-sterol reductase activity" } } }, { "id": "GO:0050614", "name": "Delta24-sterol reductase activity", "changes": { "name": { "current": "Delta24-sterol reductase activity", "previous": "delta24-sterol reductase activity" } } }, { "id": "GO:0050825", "name": "ice binding", "changes": { "synonyms": { "current": [ "\"ice crystal binding\" EXACT []", "\"ice nucleation inhibitor activity\" RELATED []" ], "previous": [ "\"antifreeze activity\" RELATED []", "\"ice crystal binding\" EXACT []", "\"ice nucleation activity\" RELATED []", "\"ice nucleation inhibitor activity\" RELATED []" ] } } }, { "id": "GO:0051996", "name": "squalene synthase [NAD(P)H] activity", "changes": { "synonyms": { "current": [ "\"farnesyl-diphosphate farnesyltransferase activity\" NARROW [EC:2.5.1.21]", "\"farnesyltransferase activity\" BROAD [EC:2.5.1.21]", "\"presqualene synthase activity\" EXACT [EC:2.5.1.21]", "\"presqualene-diphosphate synthase activity\" EXACT [EC:2.5.1.21]", "\"squalene synthase activity\" EXACT [EC:2.5.1.21]", "\"squalene synthetase activity\" RELATED [EC:2.5.1.21]" ], "previous": [ "\"squalene synthetase activity\" RELATED [EC:2.5.1.21]" ] } } }, { "id": "GO:0052849", "name": "curcumin reductase (NADP+) activity", "changes": { "name": { "current": "curcumin reductase (NADP+) activity", "previous": "NADPH-dependent curcumin reductase activity" }, "synonyms": { "current": [ "\"NADPH-dependent curcumin reductase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0061542", "name": "3-demethylubiquinol 3-O-methyltransferase activity", "changes": { "name": { "current": "3-demethylubiquinol 3-O-methyltransferase activity", "previous": "3-demethylubiquinol-n 3-O-methyltransferase activity" }, "synonyms": { "current": [ "\"2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase\" NARROW []", "\"3-demethylubiquinol-n 3-O-methyltransferase activity\" EXACT []", "\"5-demethylubiquinone-10 methyltransferase\" NARROW []", "\"5-demethylubiquinone-9 methyltransferase\" NARROW []", "\"OMHMB-methyltransferase\" RELATED []", "\"S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase\" RELATED []" ], "previous": [ "\"2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase\" NARROW []", "\"5-demethylubiquinone-10 methyltransferase\" NARROW []", "\"5-demethylubiquinone-9 methyltransferase\" NARROW []", "\"OMHMB-methyltransferase\" RELATED []", "\"S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase\" RELATED []" ] } } }, { "id": "GO:0061628", "name": "histone H3K27me3 reader activity", "changes": { "name": { "current": "histone H3K27me3 reader activity", "previous": "H3K27me3 modified histone binding" }, "definition": { "current": "\"A histone reader that recognizes a histone H3 trimethylated at lysine 27.\" [GOC:dph, PMID:23948251]", "previous": "\"Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.\" [GOC:dph, PMID:23948251]" }, "synonyms": { "current": [ "\"H3-K27me3 modified histone binding\" NARROW []", "\"H3K27me3 modified histone binding\" NARROW []" ], "previous": [ "\"H3-K27me3 modified histone binding\" EXACT [GOC:dph]" ] } } }, { "id": "GO:0061649", "name": "ubiquitin-modified histone reader activity", "changes": { "definition": { "current": "\"A histone reader that recognizes a histone bearing a ubiquinated lysine residue.\" [PMID:24526689]", "previous": "\"A molecular adaptor that recognizes and binds a histone protein containing a ubiquitination modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way.\" [GOC:dph, PMID:24526689]" } } }, { "id": "GO:0061776", "name": "ATP-dependent topological DNA co-entrapment activity", "changes": { "name": { "current": "ATP-dependent topological DNA co-entrapment activity", "previous": "topological DNA co-entrapment activity" }, "synonyms": { "current": [ "\"ATP-dependent ring closure activity\" EXACT []", "\"topological DNA entrapment activity\" RELATED []" ], "previous": [ "\"topological DNA entrapment activity\" RELATED []" ] } } }, { "id": "GO:0062072", "name": "histone H3K9me3 reader activity", "changes": { "name": { "current": "histone H3K9me3 reader activity", "previous": "H3K9me3 modified histone binding" }, "definition": { "current": "\"A histone reader that recognizes a histone H3 trimethylated at lysine 9.\" [PMID:30110338]", "previous": "\"Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.\" [PMID:30110338]" }, "synonyms": { "current": [ "\"H3K9me3 modified histone binding\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0070497", "name": "6-carboxytetrahydropterin synthase activity", "changes": { "name": { "current": "6-carboxytetrahydropterin synthase activity", "previous": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity" }, "synonyms": { "current": [ "\"6-carboxy-5,6,7,8-tetrahydropterin synthase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0090555", "name": "phosphatidylethanolamine flippase activity", "changes": { "definition": { "current": "\"Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.\" [GOC:ab, PMID:16452632, PMID:20043909]", "previous": "\"Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.\" [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36439]" } } }, { "id": "GO:0097269", "name": "all-trans-decaprenyl-diphosphate synthase activity", "changes": { "synonyms": { "current": [ "\"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" EXACT []", "\"2-trans,6-trans-farnesyl diphosphate activity\" EXACT []", "\"decaprenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"decaprenyl-diphosphate synthase activity\" BROAD [EC:2.5.1.91]", "\"polyprenylpyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"terpenoidallyltransferase activity\" BROAD [EC:2.5.1.91]", "\"terpenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.91]", "\"trans-prenyltransferase activity\" BROAD [EC:2.5.1.91]" ], "previous": [ "\"(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity\" EXACT []", "\"2-trans,6-trans-farnesyl diphosphate activity\" EXACT []" ] } } }, { "id": "GO:0098531", "name": "ligand-modulated transcription factor activity", "changes": { "name": { "current": "ligand-modulated transcription factor activity", "previous": "ligand-activated transcription factor activity" }, "synonyms": { "current": [ "\"direct ligand regulated sequence-specific DNA binding transcription factor activity\" EXACT []", "\"ligand-activated transcription factor activity\" NARROW []", "\"transcription factor activity, direct ligand regulated sequence-specific DNA binding\" EXACT []" ], "previous": [ "\"direct ligand regulated sequence-specific DNA binding transcription factor activity\" EXACT []", "\"transcription factor activity, direct ligand regulated sequence-specific DNA binding\" EXACT []" ] } } }, { "id": "GO:0099618", "name": "UDP-glucuronate dehydrogenase activity", "changes": { "name": { "current": "UDP-glucuronate dehydrogenase activity", "previous": "UDP-glucuronic acid dehydrogenase activity" }, "synonyms": { "current": [ "\"UDP-GlcUA decarboxylase activity\" EXACT []", "\"UDP-glucuronic acid dehydrogenase activity\" EXACT []" ], "previous": [ "\"UDP-GlcUA decarboxylase activity\" EXACT []" ] } } }, { "id": "GO:0102059", "name": "(2Z,6Z)-farnesyl diphosphate synthase activity", "changes": { "name": { "current": "(2Z,6Z)-farnesyl diphosphate synthase activity", "previous": "2-cis,6-cis-farnesyl pyrophosphate synthase activity" }, "synonyms": { "current": [ "\"2-cis,6-cis-farnesyl pyrophosphate synthase activity\" EXACT []", "\"cis,cis-farnesyl diphosphate synthase activity\" EXACT [EC:2.5.1.92]", "\"neryl-diphosphate:isopentenyl-diphosphate cistransferase activity\" NARROW []", "\"Z,Z-farnesyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.92]", "\"Z,Z-FPP synthase activity\" EXACT [EC:2.5.1.92]", "\"zFPS activity\" EXACT [EC:2.5.1.92]" ], "previous": [ "\"neryl-diphosphate:isopentenyl-diphosphate cistransferase activity\" NARROW []" ] } } }, { "id": "GO:0102142", "name": "dermatan 2-sulfotransferase activity", "changes": { "name": { "current": "dermatan 2-sulfotransferase activity", "previous": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity" }, "synonyms": { "current": [ "\"[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0102175", "name": "3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "changes": { "name": { "current": "3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "previous": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity" } } }, { "id": "GO:0102196", "name": "cortisol dehydrogenase (NAD+) activity", "changes": { "name": { "current": "cortisol dehydrogenase (NAD+) activity", "previous": "cortisol dehydrogenase activity" } } }, { "id": "GO:0102294", "name": "cholesterol dehydrogenase (NAD+) activity", "changes": { "name": { "current": "cholesterol dehydrogenase (NAD+) activity", "previous": "cholesterol dehydrogenase activity" } } }, { "id": "GO:0103031", "name": "L-Ala-D/L-Glu epimerase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction:L-alanyl-L-glutamate = L-alanyl-D-glutamate.\" [RHEA:28394]", "previous": "\"Catalysis of the reaction" } } }, { "id": "GO:0103040", "name": "aldose sugar dehydrogenase activity", "changes": { "comment": { "current": "N/A", "previous": "https://github.com/geneontology/go-ontology/issues/28942" } } }, { "id": "GO:0106240", "name": "labd-13Z-ene-9,15,16-triol synthase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H+ + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase].\" [GOC:eab, PMID:29315936, RHEA:62192]" } } }, { "id": "GO:0106350", "name": "all-trans-octaprenyl-diphosphate synthase activity", "changes": { "name": { "current": "all-trans-octaprenyl-diphosphate synthase activity", "previous": "octaprenyl pyrophosphate synthase activity" }, "synonyms": { "current": [ "\"octaprenyl pyrophosphate synthase activity\" EXACT [EC:2.5.1.90]", "\"terpenyl pyrophosphate synthetase activity\" BROAD [EC:2.5.1.90]", "\"trans-heptaprenyltranstransferase activity\" EXACT [EC:2.5.1.90]", "\"trans-prenyltransferase activity\" BROAD [EC:2.5.1.90]" ], "previous": "N/A" } } }, { "id": "GO:0106364", "name": "4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity", "changes": { "name": { "current": "4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity", "previous": "4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity" }, "definition": { "current": "\"Catalysis of the reaction", "previous": "\"4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin].\" [PMID:21944752, RHEA:20361]" }, "synonyms": { "current": [ "\"4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0140463", "name": "chromatin-protein adaptor activity", "changes": { "definition": { "current": "\"An adaptor activity that brings together a protein and a region of the chromatin, such as a nucleosome, to establish or maintain the chromatin localization of the protein, or the complex to which it belongs.\" [PMID:32277274]", "previous": "\"The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex.\" [PMID:32277274]" } } }, { "id": "GO:0140566", "name": "histone reader activity", "changes": { "definition": { "current": "\"A chromatin adaptor activity that brings together a protein and a specific form of histone, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.\" [PMID:11498575, PMID:25688442, PMID:31082667, PMID:34726351]", "previous": "\"A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery.\" [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]" } } }, { "id": "GO:0141096", "name": "ligand-modulated transcription repressor activity", "changes": { "name": { "current": "ligand-modulated transcription repressor activity", "previous": "ligand-activated transcription repressor activity" }, "synonyms": { "current": [ "\"ligand-activated transcription repressor activity\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0141097", "name": "ligand-modulated transcription activator activity", "changes": { "name": { "current": "ligand-modulated transcription activator activity", "previous": "ligand-activated transcription activator activity" }, "synonyms": { "current": [ "\"ligand-activated transcription activator activity\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0160197", "name": "dolichal reductase [NAD(P)+] activity", "changes": { "name": { "current": "dolichal reductase [NAD(P)+] activity", "previous": "dolichal reductase activity" } } }, { "id": "GO:0180044", "name": "borate channel activity", "changes": { "comment": { "current": "N/A", "previous": "https://github.com/geneontology/go-ontology/issues/27487" } } }, { "id": "GO:1990889", "name": "H4K20me3 modified histone binding", "changes": { "definition": { "current": "\"A histone reader that recognizes a histone H4 trimethylated at lysine 20.\" [PMID:22150589]", "previous": "\"Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.\" [PMID:22150589]" } } } ], "cellular_component": [ { "id": "GO:0005599", "name": "collagen type X trimer", "changes": { "definition": { "current": "\"A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).\" [PMID:21421911]", "previous": "\"A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).\" [ISBN:0721639976, PMID:21421911]" } } }, { "id": "GO:0009390", "name": "dimethyl sulfoxide reductase complex", "changes": { "definition": { "current": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [PMID:21357619, PMID:3280546]", "previous": "\"An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.\" [UM-BBD_enzymeID:r0207]" } } }, { "id": "GO:0060102", "name": "cuticular extracellular matrix", "changes": { "name": { "current": "cuticular extracellular matrix", "previous": "collagen and cuticulin-based cuticle extracellular matrix" }, "definition": { "current": "\"A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.\" [GOC:dph, GOC:kmv, ISSN:15518507, PMID:12619137]", "previous": "\"A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.\" [GOC:dph, GOC:kmv, ISSN:15518507]" }, "synonyms": { "current": [ "\"collagen and cuticulin-based cuticle extracellular matrix\" EXACT []", "\"collagen and cuticulin-based exoskeleton extracellular matrix\" RELATED []", "\"cuticular ECM\" EXACT []" ], "previous": [ "\"collagen and cuticulin-based exoskeleton extracellular matrix\" RELATED []" ] } } }, { "id": "GO:0062023", "name": "collagen-containing extracellular matrix", "changes": { "synonyms": { "current": [ "\"collagen-containing ECM\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0062039", "name": "biofilm matrix", "changes": { "definition": { "current": "\"A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules.\" [PMID:22571672, PMID:27129222, PMID:28516088, PMID:32663461]", "previous": "\"A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells.\" [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088]" }, "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0070505", "name": "pollen coat", "changes": { "definition": { "current": "\"A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.\" [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271, PMID:28955324]", "previous": "\"A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.\" [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271]" } } }, { "id": "GO:0098026", "name": "virus tail, tube", "changes": { "definition": { "current": "\"The internal tube of the tail of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [PMID:33188213, VZ:3960]", "previous": "\"The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [GOC:bm, VZ:3960]" }, "comment": { "current": "Applies in particular the Myoviridae bacteriophages. Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell.", "previous": "Applies in particular the Myoviridae bacteriophages." } } }, { "id": "GO:0098646", "name": "interstitial hexagonal collagen network", "changes": { "name": { "current": "interstitial hexagonal collagen network", "previous": "collagen sheet" }, "definition": { "current": "\"A hexagonal shaped collagen network formed by collagen type X trimer, mostly found in the cartilage hyaline matrix, which located in the interstitial area.\" [PMID:21421911, PMID:34948124]", "previous": "\"A protein complex that consists of collagen triple helices associated to form a sheet-like network.\" [GOC:dos, PMID:21421911]" }, "synonyms": { "current": [ "\"collagen hexagonal network\" EXACT [PMID:21421911]", "\"collagen sheet\" EXACT []" ], "previous": [ "\"collagen hexagonal network\" EXACT [PMID:21421911]" ] } } }, { "id": "GO:0099535", "name": "synapse-associated extracellular matrix", "changes": { "synonyms": { "current": [ "\"extra-synaptic extracellular matrix\" EXACT []", "\"synapse-associated ECM\" EXACT []" ], "previous": [ "\"extra-synaptic extracellular matrix\" EXACT []" ] } } }, { "id": "GO:0180022", "name": "RQC-trigger complex", "changes": { "definition": { "current": "\"A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B.\" [PMID:12077347, PMID:28757607, PMID:32099016]", "previous": "\"A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (Human TRIP4).\" [PMID:28757607, PMID:32099016]" }, "synonyms": { "current": [ "\"activating signal cointegrator 1 complex\" EXACT []", "\"ASC-1 complex\" EXACT [PMID:12077347]", "\"RQT complex\" EXACT []" ], "previous": [ "\"RQT complex\" EXACT []" ] } } } ] }, "cross_references": { "biological_process": [ { "id": "GO:0000050", "name": "urea cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70635 \"Urea cycle\"", "Wikipedia:Urea_cycle" ], "previous": [ "Wikipedia:Urea_cycle" ] } } }, { "id": "GO:0000070", "name": "mitotic sister chromatid segregation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2500257 \"Resolution of Sister Chromatid Cohesion\"" ], "previous": "N/A" } } }, { "id": "GO:0000075", "name": "cell cycle checkpoint signaling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69620 \"Cell Cycle Checkpoints\"", "Wikipedia:Cell_cycle_checkpoint" ], "previous": [ "Wikipedia:Cell_cycle_checkpoint" ] } } }, { "id": "GO:0000080", "name": "mitotic G1 phase", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69236 \"G1 Phase\"" ], "previous": "N/A" } } }, { "id": "GO:0000082", "name": "G1/S transition of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69206 \"G1/S Transition\"" ], "previous": "N/A" } } }, { "id": "GO:0000086", "name": "G2/M transition of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69275 \"G2/M Transition\"" ], "previous": "N/A" } } }, { "id": "GO:0000087", "name": "mitotic M phase", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68886 \"M Phase\"" ], "previous": "N/A" } } }, { "id": "GO:0000096", "name": "sulfur amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1614635 \"Sulfur amino acid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0000098", "name": "sulfur amino acid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1614558 \"Degradation of cysteine and homocysteine\"" ], "previous": "N/A" } } }, { "id": "GO:0000122", "name": "negative regulation of transcription by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2173795 \"Downregulation of SMAD2/3:SMAD4 transcriptional activity\"", "Reactome:R-HSA-8866904 \"Negative regulation of activity of TFAP2 (AP-2) family transcription factors\"" ], "previous": "N/A" } } }, { "id": "GO:0000154", "name": "rRNA modification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6790901 \"rRNA modification in the nucleus and cytosol\"", "Reactome:R-HSA-6793080 \"rRNA modification in the mitochondrion\"" ], "previous": "N/A" } } }, { "id": "GO:0000165", "name": "MAPK cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-169893 \"Prolonged ERK activation events\"", "Reactome:R-HSA-5673001 \"RAF/MAP kinase cascade\"", "Wikipedia:MAPK_cascade", "Wikipedia:Mitogen-activated_protein_kinase" ], "previous": [ "Wikipedia:MAPK_cascade", "Wikipedia:Mitogen-activated_protein_kinase" ] } } }, { "id": "GO:0000183", "name": "rDNA heterochromatin formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-427359 \"SIRT1 negatively regulates rRNA expression\"", "Reactome:R-HSA-427413 \"NoRC negatively regulates rRNA expression\"" ], "previous": "N/A" } } }, { "id": "GO:0000184", "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-927802 \"Nonsense-Mediated Decay (NMD)\"", "Wikipedia:Nonsense-mediated_decay", "Wikipedia:Nonsense-mediated_mRNA_decay" ], "previous": [ "Wikipedia:Nonsense-mediated_decay", "Wikipedia:Nonsense-mediated_mRNA_decay" ] } } }, { "id": "GO:0000209", "name": "protein polyubiquitination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-983168 \"Antigen processing" ], "previous": "N/A" } } }, { "id": "GO:0000236", "name": "mitotic prometaphase", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68877 \"Mitotic Prometaphase\"" ], "previous": "N/A" } } }, { "id": "GO:0000278", "name": "mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69278 \"Cell Cycle, Mitotic\"", "Wikipedia:Mitosis" ], "previous": [ "Wikipedia:Mitosis" ] } } }, { "id": "GO:0000281", "name": "mitotic cytokinesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68884 \"Mitotic Telophase/Cytokinesis\"" ], "previous": "N/A" } } }, { "id": "GO:0000288", "name": "nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429914 \"Deadenylation-dependent mRNA decay\"" ], "previous": "N/A" } } }, { "id": "GO:0000289", "name": "nuclear-transcribed mRNA poly(A) tail shortening", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429947 \"Deadenylation of mRNA\"" ], "previous": "N/A" } } }, { "id": "GO:0000387", "name": "spliceosomal snRNP assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-191859 \"snRNP Assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0000398", "name": "mRNA splicing, via spliceosome", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72163 \"mRNA Splicing - Major Pathway\"", "Reactome:R-HSA-72165 \"mRNA Splicing - Minor Pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0000423", "name": "mitophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5205647 \"Mitophagy\"", "Wikipedia:Mitophagy" ], "previous": [ "Wikipedia:Mitophagy" ] } } }, { "id": "GO:0000425", "name": "pexophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664873 \"Pexophagy\"" ], "previous": "N/A" } } }, { "id": "GO:0000715", "name": "nucleotide-excision repair, DNA damage recognition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5696394 \"DNA Damage Recognition in GG-NER\"" ], "previous": "N/A" } } }, { "id": "GO:0000723", "name": "telomere maintenance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-157579 \"Telomere Maintenance\"" ], "previous": "N/A" } } }, { "id": "GO:0000724", "name": "double-strand break repair via homologous recombination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5693538 \"Homology Directed Repair\"" ], "previous": "N/A" } } }, { "id": "GO:0000957", "name": "mitochondrial RNA catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9836573 \"Mitochondrial RNA degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0001504", "name": "neurotransmitter uptake", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112313 \"Neurotransmitter uptake and metabolism In glial cells\"" ], "previous": "N/A" } } }, { "id": "GO:0001523", "name": "retinoid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2187335 \"The retinoid cycle in cones (daylight vision)\"", "Reactome:R-HSA-2453902 \"The canonical retinoid cycle in rods (twilight vision)\"", "Reactome:R-HSA-975634 \"Retinoid metabolism and transport\"" ], "previous": "N/A" } } }, { "id": "GO:0001561", "name": "fatty acid alpha-oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-2501", "Reactome:R-HSA-389599 \"Alpha-oxidation of phytanate\"" ], "previous": [ "MetaCyc:PWY-2501" ] } } }, { "id": "GO:0001706", "name": "endoderm formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9823730 \"Formation of definitive endoderm\"" ], "previous": "N/A" } } }, { "id": "GO:0001756", "name": "somitogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9824272 \"Somitogenesis\"", "Wikipedia:Somitogenesis" ], "previous": [ "Wikipedia:Somitogenesis" ] } } }, { "id": "GO:0001822", "name": "kidney development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9830369 \"Kidney development\"", "Wikipedia:Kidney_development" ], "previous": [ "Wikipedia:Kidney_development" ] } } }, { "id": "GO:0001837", "name": "epithelial to mesenchymal transition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9758919 \"Epithelial-Mesenchymal Transition (EMT) during gastrulation\"" ], "previous": "N/A" } } }, { "id": "GO:0001867", "name": "complement activation, lectin pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166662 \"Lectin pathway of complement activation\"" ], "previous": "N/A" } } }, { "id": "GO:0001887", "name": "selenium compound metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2408499 \"Formation of selenosugars for excretion\"", "Reactome:R-HSA-2408508 \"Metabolism of ingested SeMet, Sec, MeSec into H2Se\"", "Reactome:R-HSA-2408550 \"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se\"", "Reactome:R-HSA-2408552 \"Methylation of MeSeH for excretion\"", "Reactome:R-HSA-5263617 \"Metabolism of ingested MeSeO2H into MeSeH\"" ], "previous": "N/A" } } }, { "id": "GO:0001907", "name": "symbiont-mediated killing of host cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9637698 \"Phagocyte cell death caused by cytosolic Mtb\"" ], "previous": "N/A" } } }, { "id": "GO:0001959", "name": "regulation of cytokine-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939247 \"RUNX1 regulates transcription of genes involved in interleukin signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0002003", "name": "angiotensin maturation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2022377 \"Metabolism of Angiotensinogen to Angiotensins\"" ], "previous": "N/A" } } }, { "id": "GO:0002223", "name": "stimulatory C-type lectin receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5621481 \"C-type lectin receptors (CLRs)\"" ], "previous": "N/A" } } }, { "id": "GO:0002224", "name": "toll-like receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168898 \"Toll-like Receptor Cascades\"" ], "previous": "N/A" } } }, { "id": "GO:0002250", "name": "adaptive immune response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1280218 \"Adaptive Immune System\"", "Wikipedia:Adaptive_immune_system" ], "previous": [ "Wikipedia:Adaptive_immune_system" ] } } }, { "id": "GO:0002474", "name": "antigen processing and presentation of peptide antigen via MHC class I", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-983169 \"Class I MHC mediated antigen processing & presentation\"" ], "previous": "N/A" } } }, { "id": "GO:0002479", "name": "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1236973 \"Cross-presentation of particulate exogenous antigens (phagosomes)\"", "Reactome:R-HSA-1236974 \"ER-Phagosome pathway\"", "Reactome:R-HSA-1236978 \"Cross-presentation of soluble exogenous antigens (endosomes)\"" ], "previous": "N/A" } } }, { "id": "GO:0002480", "name": "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1236977 \"Endosomal/Vacuolar pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0002576", "name": "platelet degranulation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-114608 \"Platelet degranulation\"" ], "previous": "N/A" } } }, { "id": "GO:0002753", "name": "cytoplasmic pattern recognition receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9645460 \"Alpha-protein kinase 1 signaling pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0002755", "name": "MyD88-dependent toll-like receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166058 \"MyD88:MAL(TIRAP) cascade initiated on plasma membrane\"", "Reactome:R-HSA-975871 \"MyD88 cascade initiated on plasma membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0002756", "name": "MyD88-independent toll-like receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166166 \"MyD88-independent TLR4 cascade\"", "Reactome:R-HSA-168927 \"TICAM1, RIP1-mediated IKK complex recruitment\"" ], "previous": "N/A" } } }, { "id": "GO:0002862", "name": "negative regulation of inflammatory response to antigenic stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9660821 \"ADORA2B mediated anti-inflammatory cytokines production\"", "Reactome:R-HSA-9662834 \"CD163 mediating an anti-inflammatory response\"", "Reactome:R-HSA-9664323 \"FCGR3A-mediated IL10 synthesis\"", "Reactome:R-HSA-9664535 \"LTC4-CYSLTR mediated IL4 production\"" ], "previous": "N/A" } } }, { "id": "GO:0003091", "name": "renal water homeostasis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-432040 \"Vasopressin regulates renal water homeostasis via Aquaporins\"" ], "previous": "N/A" } } }, { "id": "GO:0003334", "name": "keratinocyte development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9725554 \"Differentiation of keratinocytes in interfollicular epidermis in mammalian skin\"" ], "previous": "N/A" } } }, { "id": "GO:0005975", "name": "carbohydrate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71387 \"Metabolism of carbohydrates\"", "Wikipedia:Carbohydrate_metabolism" ], "previous": [ "Wikipedia:Carbohydrate_metabolism" ] } } }, { "id": "GO:0005977", "name": "glycogen metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8982491 \"Glycogen metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0005978", "name": "glycogen biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3322077 \"Glycogen synthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0005980", "name": "glycogen catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70221 \"Glycogen breakdown (glycogenolysis)\"" ], "previous": "N/A" } } }, { "id": "GO:0005989", "name": "lactose biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5653890 \"Lactose synthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0005999", "name": "xylulose biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163754 \"Insulin effects increased synthesis of Xylulose-5-Phosphate\"" ], "previous": "N/A" } } }, { "id": "GO:0006000", "name": "fructose metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5652084 \"Fructose metabolism\"", "Wikipedia:Fructose" ], "previous": [ "Wikipedia:Fructose" ] } } }, { "id": "GO:0006006", "name": "glucose metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70326 \"Glucose metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006015", "name": "5-phosphoribose 1-diphosphate biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73843 \"5-Phosphoribose 1-diphosphate biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006027", "name": "glycosaminoglycan catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2024101 \"CS/DS degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0006048", "name": "UDP-N-acetylglucosamine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446210 \"Synthesis of UDP-N-acetyl-glucosamine\"" ], "previous": "N/A" } } }, { "id": "GO:0006068", "name": "ethanol catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71384 \"Ethanol oxidation\"" ], "previous": "N/A" } } }, { "id": "GO:0006086", "name": "acetyl-CoA biosynthetic process from pyruvate", "changes": { "xrefs": { "current": [ "MetaCyc:PYRUVDEHYD-PWY", "Reactome:R-HSA-9861559 \"PDH complex synthesizes acetyl-CoA from PYR\"" ], "previous": [ "MetaCyc:PYRUVDEHYD-PWY" ] } } }, { "id": "GO:0006090", "name": "pyruvate metabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:P41-PWY", "Reactome:R-HSA-70268 \"Pyruvate metabolism\"", "Wikipedia:Pyruvic_acid" ], "previous": [ "MetaCyc:P41-PWY", "Wikipedia:Pyruvic_acid" ] } } }, { "id": "GO:0006094", "name": "gluconeogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70263 \"Gluconeogenesis\"", "Wikipedia:Gluconeogenesis" ], "previous": [ "Wikipedia:Gluconeogenesis" ] } } }, { "id": "GO:0006098", "name": "pentose-phosphate shunt", "changes": { "xrefs": { "current": [ "KEGG_PATHWAY:map00030", "MetaCyc:PENTOSE-P-PWY", "Reactome:R-HSA-71336 \"Pentose phosphate pathway\"", "Wikipedia:Pentose_phosphate_pathway" ], "previous": [ "KEGG_PATHWAY:map00030", "MetaCyc:PENTOSE-P-PWY", "Wikipedia:Pentose_phosphate_pathway" ] } } }, { "id": "GO:0006099", "name": "tricarboxylic acid cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71403 \"Citric acid cycle (TCA cycle)\"", "Wikipedia:Tricarboxylic_acid_cycle" ], "previous": [ "Wikipedia:Tricarboxylic_acid_cycle" ] } } }, { "id": "GO:0006103", "name": "2-oxoglutarate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2978092 \"Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate\"", "Reactome:R-HSA-880009 \"Interconversion of 2-oxoglutarate and 2-hydroxyglutarate\"" ], "previous": "N/A" } } }, { "id": "GO:0006110", "name": "regulation of glycolytic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-170822 \"Regulation of Glucokinase by Glucokinase Regulatory Protein\"" ], "previous": "N/A" } } }, { "id": "GO:0006113", "name": "fermentation", "changes": { "xrefs": { "current": [ "MetaCyc:Fermentation", "Wikipedia:Fermentation_(biochemistry)" ], "previous": [ "MetaCyc:FERMENTATION-PWY", "Wikipedia:Fermentation_(biochemistry)" ] } } }, { "id": "GO:0006124", "name": "ferredoxin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2395516 \"Electron transport from NADPH to Ferredoxin\"" ], "previous": "N/A" } } }, { "id": "GO:0006195", "name": "purine nucleotide catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-74259 \"Purine catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006260", "name": "DNA replication", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-176187 \"Activation of ATR in response to replication stress\"", "Reactome:R-HSA-69239 \"Synthesis of DNA\"", "Wikipedia:DNA_replication" ], "previous": [ "Wikipedia:DNA_replication" ] } } }, { "id": "GO:0006261", "name": "DNA-templated DNA replication", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69306 \"DNA Replication\"" ], "previous": "N/A" } } }, { "id": "GO:0006270", "name": "DNA replication initiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68952 \"DNA replication initiation\"", "Reactome:R-HSA-68962 \"Activation of the pre-replicative complex\"" ], "previous": "N/A" } } }, { "id": "GO:0006271", "name": "DNA strand elongation involved in DNA replication", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69190 \"DNA strand elongation\"" ], "previous": "N/A" } } }, { "id": "GO:0006278", "name": "RNA-templated DNA biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162589 \"Reverse Transcription of HIV RNA\"" ], "previous": "N/A" } } }, { "id": "GO:0006281", "name": "DNA repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73894 \"DNA Repair\"", "Wikipedia:DNA_repair" ], "previous": [ "Wikipedia:DNA_repair" ] } } }, { "id": "GO:0006283", "name": "transcription-coupled nucleotide-excision repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6781827 \"Transcription-Coupled Nucleotide Excision Repair (TC-NER)\"" ], "previous": "N/A" } } }, { "id": "GO:0006284", "name": "base-excision repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73884 \"Base Excision Repair\"", "Reactome:R-HSA-73930 \"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway\"", "Wikipedia:Base_excision_repair" ], "previous": [ "Wikipedia:Base_excision_repair" ] } } }, { "id": "GO:0006285", "name": "base-excision repair, AP site formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73929 \"Base-Excision Repair, AP Site Formation\"" ], "previous": "N/A" } } }, { "id": "GO:0006287", "name": "base-excision repair, gap-filling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73933 \"Resolution of Abasic Sites (AP sites)\"" ], "previous": "N/A" } } }, { "id": "GO:0006289", "name": "nucleotide-excision repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5696398 \"Nucleotide Excision Repair\"", "Reactome:R-HSA-5696400 \"Dual Incision in GG-NER\"" ], "previous": "N/A" } } }, { "id": "GO:0006297", "name": "nucleotide-excision repair, DNA gap filling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5696397 \"Gap-filling DNA repair synthesis and ligation in GG-NER\"" ], "previous": "N/A" } } }, { "id": "GO:0006298", "name": "mismatch repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5358508 \"Mismatch Repair\"", "Wikipedia:DNA_mismatch_repair" ], "previous": [ "Wikipedia:DNA_mismatch_repair" ] } } }, { "id": "GO:0006302", "name": "double-strand break repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5693532 \"DNA Double-Strand Break Repair\"" ], "previous": "N/A" } } }, { "id": "GO:0006303", "name": "double-strand break repair via nonhomologous end joining", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5693571 \"Nonhomologous End-Joining (NHEJ)\"" ], "previous": "N/A" } } }, { "id": "GO:0006307", "name": "DNA alkylation repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5657655 \"MGMT-mediated DNA damage reversal\"", "Reactome:R-HSA-73943 \"Reversal of alkylation damage by DNA dioxygenases\"" ], "previous": "N/A" } } }, { "id": "GO:0006309", "name": "apoptotic DNA fragmentation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-140342 \"Apoptosis induced DNA fragmentation\"" ], "previous": "N/A" } } }, { "id": "GO:0006325", "name": "chromatin organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-4839726 \"Chromatin organization\"" ], "previous": "N/A" } } }, { "id": "GO:0006334", "name": "nucleosome assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-774815 \"Nucleosome assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0006351", "name": "DNA-templated transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2173793 \"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\"", "Reactome:R-HSA-74160 \"Gene expression (Transcription)\"", "Wikipedia:Transcription_(genetics)" ], "previous": [ "Wikipedia:Transcription_(genetics)" ] } } }, { "id": "GO:0006355", "name": "regulation of DNA-templated transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9013695 \"NOTCH4 Intracellular Domain Regulates Transcription\"", "Reactome:R-HSA-9762293 \"Regulation of CDH11 gene transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0006357", "name": "regulation of transcription by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8864260 \"Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors\"" ], "previous": "N/A" } } }, { "id": "GO:0006360", "name": "transcription by RNA polymerase I", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73864 \"RNA Polymerase I Transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0006361", "name": "transcription initiation at RNA polymerase I promoter", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73854 \"RNA Polymerase I Promoter Clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0006363", "name": "termination of RNA polymerase I transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73863 \"RNA Polymerase I Transcription Termination\"" ], "previous": "N/A" } } }, { "id": "GO:0006364", "name": "rRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72312 \"rRNA processing\"" ], "previous": "N/A" } } }, { "id": "GO:0006366", "name": "transcription by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73857 \"RNA Polymerase II Transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0006367", "name": "transcription initiation at RNA polymerase II promoter", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167161 \"HIV Transcription Initiation\"", "Reactome:R-HSA-2032785 \"YAP1- and WWTR1 (TAZ)-stimulated gene expression\"", "Reactome:R-HSA-350054 \"Notch-HLH transcription pathway\"", "Reactome:R-HSA-383280 \"Nuclear Receptor transcription pathway\"", "Reactome:R-HSA-73779 \"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening\"", "Reactome:R-HSA-75953 \"RNA Polymerase II Transcription Initiation\"" ], "previous": "N/A" } } }, { "id": "GO:0006368", "name": "transcription elongation by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167169 \"HIV Transcription Elongation\"", "Reactome:R-HSA-73776 \"RNA Polymerase II Promoter Escape\"", "Reactome:R-HSA-75955 \"RNA Polymerase II Transcription Elongation\"" ], "previous": "N/A" } } }, { "id": "GO:0006369", "name": "termination of RNA polymerase II transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73856 \"RNA Polymerase II Transcription Termination\"" ], "previous": "N/A" } } }, { "id": "GO:0006370", "name": "7-methylguanosine mRNA capping", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72086 \"mRNA Capping\"" ], "previous": "N/A" } } }, { "id": "GO:0006382", "name": "adenosine to inosine editing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75064 \"mRNA Editing" ], "previous": "N/A" } } }, { "id": "GO:0006383", "name": "transcription by RNA polymerase III", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-74158 \"RNA Polymerase III Transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0006385", "name": "transcription elongation by RNA polymerase III", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73780 \"RNA Polymerase III Chain Elongation\"" ], "previous": "N/A" } } }, { "id": "GO:0006386", "name": "termination of RNA polymerase III transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73980 \"RNA Polymerase III Transcription Termination\"" ], "previous": "N/A" } } }, { "id": "GO:0006390", "name": "mitochondrial transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75944 \"Transcription from mitochondrial promoters\"" ], "previous": "N/A" } } }, { "id": "GO:0006391", "name": "transcription initiation at mitochondrial promoter", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163282 \"Mitochondrial transcription initiation\"" ], "previous": "N/A" } } }, { "id": "GO:0006393", "name": "termination of mitochondrial transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163316 \"Mitochondrial transcription termination\"" ], "previous": "N/A" } } }, { "id": "GO:0006398", "name": "mRNA 3'-end processing by stem-loop binding and cleavage", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-77588 \"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs\"" ], "previous": "N/A" } } }, { "id": "GO:0006400", "name": "tRNA modification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6782315 \"tRNA modification in the nucleus and cytosol\"" ], "previous": "N/A" } } }, { "id": "GO:0006406", "name": "mRNA export from nucleus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72202 \"Transport of Mature Transcript to Cytoplasm\"" ], "previous": "N/A" } } }, { "id": "GO:0006412", "name": "translation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72766 \"Translation\"", "Wikipedia:Translation_(genetics)" ], "previous": [ "Wikipedia:Translation_(genetics)" ] } } }, { "id": "GO:0006413", "name": "translational initiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72613 \"Eukaryotic Translation Initiation\"" ], "previous": "N/A" } } }, { "id": "GO:0006414", "name": "translational elongation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156842 \"Eukaryotic Translation Elongation\"" ], "previous": "N/A" } } }, { "id": "GO:0006415", "name": "translational termination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72764 \"Eukaryotic Translation Termination\"" ], "previous": "N/A" } } }, { "id": "GO:0006418", "name": "tRNA aminoacylation for protein translation", "changes": { "xrefs": { "current": [ "MetaCyc:TRNA-CHARGING-PWY", "Reactome:R-HSA-379724 \"tRNA Aminoacylation\"" ], "previous": [ "MetaCyc:TRNA-CHARGING-PWY" ] } } }, { "id": "GO:0006457", "name": "protein folding", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-389960 \"Formation of tubulin folding intermediates by CCT/TriC\"", "Reactome:R-HSA-390466 \"Chaperonin-mediated protein folding\"", "Reactome:R-HSA-532668 \"N-glycan trimming in the ER and Calnexin/Calreticulin cycle\"", "Wikipedia:Protein_folding" ], "previous": [ "Wikipedia:Protein_folding" ] } } }, { "id": "GO:0006465", "name": "signal peptide processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-159782 \"Removal of aminoterminal propeptides from gamma-carboxylated proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0006479", "name": "protein methylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8876725 \"Protein methylation\"" ], "previous": "N/A" } } }, { "id": "GO:0006488", "name": "dolichol-linked oligosaccharide biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446193 \"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein\"" ], "previous": "N/A" } } }, { "id": "GO:0006489", "name": "dolichyl diphosphate biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446199 \"Synthesis of Dolichyl-phosphate\"" ], "previous": "N/A" } } }, { "id": "GO:0006493", "name": "protein O-linked glycosylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5173105 \"O-linked glycosylation\"", "RESID:AA0153", "RESID:AA0154", "RESID:AA0155", "RESID:AA0157", "RESID:AA0212" ], "previous": [ "RESID:AA0153", "RESID:AA0154", "RESID:AA0155", "RESID:AA0157", "RESID:AA0212" ] } } }, { "id": "GO:0006501", "name": "C-terminal protein lipidation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163125 \"Post-translational modification" ], "previous": "N/A" } } }, { "id": "GO:0006506", "name": "GPI anchor biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162710 \"Synthesis of glycosylphosphatidylinositol (GPI)\"" ], "previous": "N/A" } } }, { "id": "GO:0006518", "name": "peptide metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2980736 \"Peptide hormone metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006521", "name": "regulation of amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-350562 \"Regulation of ornithine decarboxylase (ODC)\"" ], "previous": "N/A" } } }, { "id": "GO:0006546", "name": "glycine catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6783984 \"Glycine degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0006548", "name": "L-histidine catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70921 \"Histidine catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006554", "name": "lysine catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71064 \"Lysine catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006558", "name": "L-phenylalanine metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964208 \"Phenylalanine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006562", "name": "proline catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70688 \"Proline catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006564", "name": "L-serine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:SERSYN-PWY", "Reactome:R-HSA-977347 \"Serine biosynthesis\"" ], "previous": [ "MetaCyc:SERSYN-PWY" ] } } }, { "id": "GO:0006569", "name": "L-tryptophan catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71240 \"Tryptophan catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006572", "name": "tyrosine catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963684 \"Tyrosine catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006590", "name": "thyroid hormone generation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-209968 \"Thyroxine biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006595", "name": "polyamine metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-351202 \"Metabolism of polyamines\"" ], "previous": "N/A" } } }, { "id": "GO:0006596", "name": "polyamine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-351200 \"Interconversion of polyamines\"" ], "previous": "N/A" } } }, { "id": "GO:0006600", "name": "creatine metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71288 \"Creatine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006601", "name": "creatine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCGREAT-PWY" ], "previous": "N/A" } } }, { "id": "GO:0006614", "name": "SRP-dependent cotranslational protein targeting to membrane", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1799339 \"SRP-dependent cotranslational protein targeting to membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0006626", "name": "protein targeting to mitochondrion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1268020 \"Mitochondrial protein import\"" ], "previous": "N/A" } } }, { "id": "GO:0006629", "name": "lipid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-556833 \"Metabolism of lipids\"", "Wikipedia:Lipid_metabolism" ], "previous": [ "Wikipedia:Lipid_metabolism" ] } } }, { "id": "GO:0006631", "name": "fatty acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211935 \"Fatty acids\"", "Reactome:R-HSA-434313 \"Intracellular metabolism of fatty acids regulates insulin secretion\"", "Reactome:R-HSA-8978868 \"Fatty acid metabolism\"", "Wikipedia:Fatty_acid_metabolism" ], "previous": [ "Wikipedia:Fatty_acid_metabolism" ] } } }, { "id": "GO:0006635", "name": "fatty acid beta-oxidation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-77289 \"Mitochondrial Fatty Acid Beta-Oxidation\"" ], "previous": "N/A" } } }, { "id": "GO:0006641", "name": "triglyceride metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8979227 \"Triglyceride metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006644", "name": "phospholipid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483115 \"Hydrolysis of LPC\"", "Reactome:R-HSA-1483152 \"Hydrolysis of LPE\"", "Reactome:R-HSA-1483257 \"Phospholipid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006646", "name": "phosphatidylethanolamine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483213 \"Synthesis of PE\"" ], "previous": "N/A" } } }, { "id": "GO:0006654", "name": "phosphatidic acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483166 \"Synthesis of PA\"" ], "previous": "N/A" } } }, { "id": "GO:0006655", "name": "phosphatidylglycerol biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483148 \"Synthesis of PG\"" ], "previous": "N/A" } } }, { "id": "GO:0006656", "name": "phosphatidylcholine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483191 \"Synthesis of PC\"" ], "previous": "N/A" } } }, { "id": "GO:0006659", "name": "phosphatidylserine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483101 \"Synthesis of PS\"" ], "previous": "N/A" } } }, { "id": "GO:0006661", "name": "phosphatidylinositol biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483226 \"Synthesis of PI\"", "Reactome:R-HSA-1483248 \"Synthesis of PIPs at the ER membrane\"", "Reactome:R-HSA-1660499 \"Synthesis of PIPs at the plasma membrane\"", "Reactome:R-HSA-1660514 \"Synthesis of PIPs at the Golgi membrane\"", "Reactome:R-HSA-1660516 \"Synthesis of PIPs at the early endosome membrane\"", "Reactome:R-HSA-1660517 \"Synthesis of PIPs at the late endosome membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0006665", "name": "sphingolipid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-428157 \"Sphingolipid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006687", "name": "glycosphingolipid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1660662 \"Glycosphingolipid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0006688", "name": "glycosphingolipid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9840309 \"Glycosphingolipid biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006690", "name": "icosanoid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211979 \"Eicosanoids\"" ], "previous": "N/A" } } }, { "id": "GO:0006691", "name": "leukotriene metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142691 \"Synthesis of Leukotrienes (LT) and Eoxins (EX)\"" ], "previous": "N/A" } } }, { "id": "GO:0006692", "name": "prostanoid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-140180 \"COX reactions\"" ], "previous": "N/A" } } }, { "id": "GO:0006695", "name": "cholesterol biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-191273 \"Cholesterol biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006699", "name": "bile acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-192105 \"Synthesis of bile acids and bile salts\"" ], "previous": "N/A" } } }, { "id": "GO:0006700", "name": "C21-steroid hormone biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196108 \"Pregnenolone biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006702", "name": "androgen biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193048 \"Androgen biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006703", "name": "estrogen biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193144 \"Estrogen biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006704", "name": "glucocorticoid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-194002 \"Glucocorticoid biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006705", "name": "mineralocorticoid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193993 \"Mineralocorticoid biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0006740", "name": "NADPH regeneration", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-389542 \"NADPH regeneration\"" ], "previous": "N/A" } } }, { "id": "GO:0006744", "name": "ubiquinone biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:UBISYN-PWY", "Reactome:R-HSA-2142789 \"Ubiquinol biosynthesis\"" ], "previous": [ "MetaCyc:UBISYN-PWY" ] } } }, { "id": "GO:0006750", "name": "glutathione biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLUTATHIONESYN-PWY", "Reactome:R-HSA-174403 \"Glutathione synthesis and recycling\"" ], "previous": [ "MetaCyc:GLUTATHIONESYN-PWY" ] } } }, { "id": "GO:0006766", "name": "vitamin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211916 \"Vitamins\"" ], "previous": "N/A" } } }, { "id": "GO:0006767", "name": "water-soluble vitamin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196849 \"Metabolism of water-soluble vitamins and cofactors\"" ], "previous": "N/A" } } }, { "id": "GO:0006768", "name": "biotin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196780 \"Biotin transport and metabolism\"", "Wikipedia:Biotin" ], "previous": [ "Wikipedia:Biotin" ] } } }, { "id": "GO:0006771", "name": "riboflavin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196843 \"Vitamin B2 (riboflavin) metabolism\"", "Wikipedia:Riboflavin" ], "previous": [ "Wikipedia:Riboflavin" ] } } }, { "id": "GO:0006775", "name": "fat-soluble vitamin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6806667 \"Metabolism of fat-soluble vitamins\"" ], "previous": "N/A" } } }, { "id": "GO:0006778", "name": "porphyrin-containing compound metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-189445 \"Metabolism of porphyrins\"" ], "previous": "N/A" } } }, { "id": "GO:0006783", "name": "heme biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:HEMESYN2-PWY", "Reactome:R-HSA-189451 \"Heme biosynthesis\"" ], "previous": [ "MetaCyc:HEMESYN2-PWY" ] } } }, { "id": "GO:0006805", "name": "xenobiotic metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211859 \"Biological oxidations\"", "Reactome:R-HSA-211981 \"Xenobiotics\"", "Reactome:R-HSA-2161541 \"Abacavir metabolism\"", "Reactome:R-HSA-9748784 \"Drug ADME\"", "Wikipedia:Drug_metabolism", "Wikipedia:Xenobiotic_metabolism" ], "previous": [ "Wikipedia:Drug_metabolism", "Wikipedia:Xenobiotic_metabolism" ] } } }, { "id": "GO:0006810", "name": "transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-382551 \"Transport of small molecules\"" ], "previous": "N/A" } } }, { "id": "GO:0006811", "name": "monoatomic ion transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-425393 \"Transport of inorganic cations/anions and amino acids/oligopeptides\"" ], "previous": "N/A" } } }, { "id": "GO:0006833", "name": "water transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-445717 \"Aquaporin-mediated transport\"" ], "previous": "N/A" } } }, { "id": "GO:0006836", "name": "neurotransmitter transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-181429 \"Serotonin Neurotransmitter Release Cycle\"", "Reactome:R-HSA-181430 \"Norepinephrine Neurotransmitter Release Cycle\"", "Reactome:R-HSA-210500 \"Glutamate Neurotransmitter Release Cycle\"", "Reactome:R-HSA-212676 \"Dopamine Neurotransmitter Release Cycle\"", "Reactome:R-HSA-264642 \"Acetylcholine Neurotransmitter Release Cycle\"" ], "previous": "N/A" } } }, { "id": "GO:0006851", "name": "mitochondrial calcium ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8949215 \"Mitochondrial calcium ion transport\"" ], "previous": "N/A" } } }, { "id": "GO:0006853", "name": "carnitine shuttle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-200425 \"Carnitine shuttle\"", "Wikipedia:Carnitine#Role_in_fatty_acid_metabolism" ], "previous": [ "Wikipedia:Carnitine#Role_in_fatty_acid_metabolism" ] } } }, { "id": "GO:0006865", "name": "amino acid transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-352230 \"Amino acid transport across the plasma membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0006869", "name": "lipid transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1369062 \"ABC transporters in lipid homeostasis\"" ], "previous": "N/A" } } }, { "id": "GO:0006879", "name": "intracellular iron ion homeostasis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-917937 \"Iron uptake and transport\"" ], "previous": "N/A" } } }, { "id": "GO:0006888", "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-159763 \"Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus\"", "Reactome:R-HSA-199977 \"ER to Golgi Anterograde Transport\"" ], "previous": "N/A" } } }, { "id": "GO:0006890", "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6811434 \"COPI-dependent Golgi-to-ER retrograde traffic\"" ], "previous": "N/A" } } }, { "id": "GO:0006892", "name": "post-Golgi vesicle-mediated transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-199992 \"trans-Golgi Network Vesicle Budding\"" ], "previous": "N/A" } } }, { "id": "GO:0006898", "name": "receptor-mediated endocytosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2173782 \"Binding and Uptake of Ligands by Scavenger Receptors\"", "Wikipedia:Receptor-mediated_endocytosis" ], "previous": [ "Wikipedia:Receptor-mediated_endocytosis" ] } } }, { "id": "GO:0006909", "name": "phagocytosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664417 \"Leishmania phagocytosis\"", "Wikipedia:Phagocytosis" ], "previous": [ "Wikipedia:Phagocytosis" ] } } }, { "id": "GO:0006914", "name": "autophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9612973 \"Autophagy\"", "Wikipedia:Autophagy_(cellular)" ], "previous": [ "Wikipedia:Autophagy_(cellular)" ] } } }, { "id": "GO:0006915", "name": "apoptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-109581 \"Apoptosis\"", "Wikipedia:Apoptosis" ], "previous": [ "Wikipedia:Apoptosis" ] } } }, { "id": "GO:0006925", "name": "inflammatory cell apoptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168277 \"Influenza Virus Induced Apoptosis\"" ], "previous": "N/A" } } }, { "id": "GO:0006936", "name": "muscle contraction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-445355 \"Smooth Muscle Contraction\"", "Wikipedia:Muscle_contraction" ], "previous": [ "Wikipedia:Muscle_contraction" ] } } }, { "id": "GO:0006956", "name": "complement activation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166658 \"Complement cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0006957", "name": "complement activation, alternative pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-173736 \"Alternative complement activation\"" ], "previous": "N/A" } } }, { "id": "GO:0006958", "name": "complement activation, classical pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-173623 \"Classical antibody-mediated complement activation\"" ], "previous": "N/A" } } }, { "id": "GO:0006996", "name": "organelle organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1852241 \"Organelle biogenesis and maintenance\"" ], "previous": "N/A" } } }, { "id": "GO:0007004", "name": "telomere maintenance via telomerase", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-171319 \"Telomere Extension By Telomerase\"" ], "previous": "N/A" } } }, { "id": "GO:0007005", "name": "mitochondrion organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1592230 \"Mitochondrial biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0007018", "name": "microtubule-based movement", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-983189 \"Kinesins\"" ], "previous": "N/A" } } }, { "id": "GO:0007023", "name": "post-chaperonin tubulin folding pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-389977 \"Post-chaperonin tubulin folding pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0007049", "name": "cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1640170 \"Cell Cycle\"", "Wikipedia:Cell_cycle" ], "previous": [ "Wikipedia:Cell_cycle" ] } } }, { "id": "GO:0007052", "name": "mitotic spindle organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9648025 \"EML4 and NUDC in mitotic spindle formation\"" ], "previous": "N/A" } } }, { "id": "GO:0007062", "name": "sister chromatid cohesion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2468052 \"Establishment of Sister Chromatid Cohesion\"" ], "previous": "N/A" } } }, { "id": "GO:0007076", "name": "mitotic chromosome condensation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2299718 \"Condensation of Prophase Chromosomes\"", "Reactome:R-HSA-2514853 \"Condensation of Prometaphase Chromosomes\"" ], "previous": "N/A" } } }, { "id": "GO:0007077", "name": "mitotic nuclear membrane disassembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2980766 \"Nuclear Envelope Breakdown\"" ], "previous": "N/A" } } }, { "id": "GO:0007084", "name": "mitotic nuclear membrane reassembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2995410 \"Nuclear Envelope (NE) Reassembly\"" ], "previous": "N/A" } } }, { "id": "GO:0007091", "name": "metaphase/anaphase transition of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68881 \"Mitotic Metaphase/Anaphase Transition\"" ], "previous": "N/A" } } }, { "id": "GO:0007094", "name": "mitotic spindle assembly checkpoint signaling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69618 \"Mitotic Spindle Checkpoint\"" ], "previous": "N/A" } } }, { "id": "GO:0007096", "name": "regulation of exit from mitosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-176409 \"APC/C:Cdc20 mediated degradation of mitotic proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0007165", "name": "signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-212718 \"EGFR interacts with phospholipase C-gamma\"", "Wikipedia:Signal_transduction" ], "previous": [ "Wikipedia:Signal_transduction" ] } } }, { "id": "GO:0007166", "name": "cell surface receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73887 \"Death Receptor Signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0007169", "name": "cell surface receptor protein tyrosine kinase signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-187015 \"Activation of TRKA receptors\"" ], "previous": "N/A" } } }, { "id": "GO:0007173", "name": "epidermal growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-177929 \"Signaling by EGFR\"" ], "previous": "N/A" } } }, { "id": "GO:0007179", "name": "transforming growth factor beta receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-170834 \"Signaling by TGF-beta Receptor Complex\"" ], "previous": "N/A" } } }, { "id": "GO:0007186", "name": "G protein-coupled receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-373076 \"Class A/1 (Rhodopsin-like receptors)\"", "Reactome:R-HSA-388396 \"GPCR downstream signalling\"" ], "previous": "N/A" } } }, { "id": "GO:0007189", "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-170660 \"Adenylate cyclase activating pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0007190", "name": "activation of adenylate cyclase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-187024 \"NGF-independant TRKA activation\"" ], "previous": "N/A" } } }, { "id": "GO:0007193", "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-170670 \"Adenylate cyclase inhibitory pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0007219", "name": "Notch signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-157118 \"Signaling by NOTCH\"", "Wikipedia:Notch_signaling_pathway" ], "previous": [ "Wikipedia:Notch_signaling_pathway" ] } } }, { "id": "GO:0007221", "name": "positive regulation of transcription of Notch receptor target", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9013508 \"NOTCH3 Intracellular Domain Regulates Transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0007223", "name": "Wnt signaling pathway, calcium modulating pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-4086398 \"Ca2+ pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0007249", "name": "canonical NF-kappaB signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5357956 \"TNFR1-induced NF-kappa-B signaling pathway\"", "Reactome:R-HSA-9014325 \"TICAM1,TRAF6-dependent induction of TAK1 complex\"", "Reactome:R-HSA-937072 \"TRAF6-mediated induction of TAK1 complex within TLR4 complex\"" ], "previous": "N/A" } } }, { "id": "GO:0007254", "name": "JNK cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-450321 \"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1\"" ], "previous": "N/A" } } }, { "id": "GO:0007264", "name": "small GTPase-mediated signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-187706 \"Signalling to p38 via RIT and RIN\"", "Reactome:R-HSA-194315 \"Signaling by Rho GTPases\"" ], "previous": "N/A" } } }, { "id": "GO:0007265", "name": "Ras protein signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1169092 \"Activation of RAS in B cells\"", "Reactome:R-HSA-167044 \"Signalling to RAS\"" ], "previous": "N/A" } } }, { "id": "GO:0007268", "name": "chemical synaptic transmission", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112316 \"Neuronal System\"", "Reactome:R-HSA-442720 \"CREB1 phosphorylation through the activation of Adenylate Cyclase\"", "Reactome:R-HSA-442729 \"CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde\"", "Reactome:R-HSA-442742 \"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling\"", "Reactome:R-HSA-451307 \"Activation of Na-permeable kainate receptors\"", "Reactome:R-HSA-451308 \"Activation of Ca-permeable Kainate Receptor\"", "Reactome:R-HSA-9619229 \"Activation of RAC1 downstream of NMDARs\"", "Reactome:R-HSA-9619483 \"Activation of AMPK downstream of NMDARs\"", "Reactome:R-HSA-9620244 \"Long-term potentiation\"", "Wikipedia:Neurotransmission" ], "previous": [ "Wikipedia:Neurotransmission" ] } } }, { "id": "GO:0007269", "name": "neurotransmitter secretion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112310 \"Neurotransmitter release cycle\"" ], "previous": "N/A" } } }, { "id": "GO:0007281", "name": "germ cell development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9827857 \"Specification of primordial germ cells\"" ], "previous": "N/A" } } }, { "id": "GO:0007338", "name": "single fertilization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1187000 \"Fertilization\"" ], "previous": "N/A" } } }, { "id": "GO:0007340", "name": "acrosome reaction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1300645 \"Acrosome Reaction and Sperm:Oocyte Membrane Binding\"", "Wikipedia:Acrosome_reaction" ], "previous": [ "Wikipedia:Acrosome_reaction" ] } } }, { "id": "GO:0007346", "name": "regulation of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2465910 \"MASTL Facilitates Mitotic Progression\"", "Reactome:R-HSA-68911 \"G2 Phase\"" ], "previous": "N/A" } } }, { "id": "GO:0007369", "name": "gastrulation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9758941 \"Gastrulation\"", "Wikipedia:Gastrulation" ], "previous": [ "Wikipedia:Gastrulation" ] } } }, { "id": "GO:0007399", "name": "nervous system development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9675108 \"Nervous system development\"" ], "previous": "N/A" } } }, { "id": "GO:0007411", "name": "axon guidance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-422475 \"Axon guidance\"", "Wikipedia:Axon_guidance" ], "previous": [ "Wikipedia:Axon_guidance" ] } } }, { "id": "GO:0007586", "name": "digestion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8935690 \"Digestion\"", "Wikipedia:Digestion" ], "previous": [ "Wikipedia:Digestion" ] } } }, { "id": "GO:0007596", "name": "blood coagulation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-109582 \"Hemostasis\"", "Wikipedia:Coagulation" ], "previous": [ "Wikipedia:Coagulation" ] } } }, { "id": "GO:0007597", "name": "blood coagulation, intrinsic pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-140837 \"Intrinsic Pathway of Fibrin Clot Formation\"" ], "previous": "N/A" } } }, { "id": "GO:0007598", "name": "blood coagulation, extrinsic pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-140834 \"Extrinsic Pathway of Fibrin Clot Formation\"" ], "previous": "N/A" } } }, { "id": "GO:0007600", "name": "sensory perception", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9709957 \"Sensory Perception\"", "Wikipedia:Perception" ], "previous": [ "Wikipedia:Perception" ] } } }, { "id": "GO:0007603", "name": "phototransduction, visible light", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2187338 \"Visual phototransduction\"" ], "previous": "N/A" } } }, { "id": "GO:0007605", "name": "sensory perception of sound", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9659379 \"Sensory processing of sound\"", "Wikipedia:Hearing_(sense)" ], "previous": [ "Wikipedia:Hearing_(sense)" ] } } }, { "id": "GO:0007623", "name": "circadian rhythm", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-400253 \"Circadian Clock\"", "Wikipedia:Circadian_rhythm" ], "previous": [ "Wikipedia:Circadian_rhythm" ] } } }, { "id": "GO:0008033", "name": "tRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72306 \"tRNA processing\"" ], "previous": "N/A" } } }, { "id": "GO:0008104", "name": "protein localization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9609507 \"Protein localization\"" ], "previous": "N/A" } } }, { "id": "GO:0008152", "name": "metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1430728 \"Metabolism\"", "Wikipedia:Metabolism" ], "previous": [ "Wikipedia:Metabolism" ] } } }, { "id": "GO:0008202", "name": "steroid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8957322 \"Metabolism of steroids\"", "Wikipedia:Steroid_metabolism" ], "previous": [ "Wikipedia:Steroid_metabolism" ] } } }, { "id": "GO:0008206", "name": "bile acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-194068 \"Bile acid and bile salt metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0008286", "name": "insulin receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-74752 \"Signaling by Insulin receptor\"" ], "previous": "N/A" } } }, { "id": "GO:0008380", "name": "RNA splicing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72172 \"mRNA Splicing\"", "Wikipedia:RNA_splicing" ], "previous": [ "Wikipedia:RNA_splicing" ] } } }, { "id": "GO:0008543", "name": "fibroblast growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-190236 \"Signaling by FGFR\"" ], "previous": "N/A" } } }, { "id": "GO:0008584", "name": "male gonad development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9690406 \"Transcriptional regulation of testis differentiation\"" ], "previous": "N/A" } } }, { "id": "GO:0008611", "name": "ether lipid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75896 \"Plasmalogen biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0008612", "name": "peptidyl-lysine modification to peptidyl-hypusine", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-204626 \"Hypusine synthesis from eIF5A-lysine\"", "RESID:AA0116" ], "previous": [ "RESID:AA0116" ] } } }, { "id": "GO:0008645", "name": "hexose transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-189200 \"Cellular hexose transport\"" ], "previous": "N/A" } } }, { "id": "GO:0009062", "name": "fatty acid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-390918 \"Peroxisomal lipid metabolism\"", "Wikipedia:Fatty_acid_degradation" ], "previous": [ "Wikipedia:Fatty_acid_degradation" ] } } }, { "id": "GO:0009064", "name": "glutamine family amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964539 \"Glutamate and glutamine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009066", "name": "aspartate family amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963693 \"Aspartate and asparagine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009072", "name": "aromatic amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963691 \"Phenylalanine and tyrosine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009078", "name": "pyruvate family amino acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964540 \"Alanine metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009083", "name": "branched-chain amino acid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70895 \"Branched-chain amino acid catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009168", "name": "purine ribonucleoside monophosphate biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73817 \"Purine ribonucleoside monophosphate biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0009226", "name": "nucleotide-sugar biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-173599 \"Formation of the active cofactor, UDP-glucuronate\"" ], "previous": "N/A" } } }, { "id": "GO:0009235", "name": "cobalamin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9759218 \"Cobalamin (Cbl) metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009249", "name": "protein lipoylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9857492 \"Protein lipoylation\"" ], "previous": "N/A" } } }, { "id": "GO:0009267", "name": "cellular response to starvation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9711097 \"Cellular response to starvation\"" ], "previous": "N/A" } } }, { "id": "GO:0009298", "name": "GDP-mannose biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446205 \"Synthesis of GDP-mannose\"" ], "previous": "N/A" } } }, { "id": "GO:0009312", "name": "oligosaccharide biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9033658 \"Blood group systems biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0009313", "name": "oligosaccharide catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8853383 \"Lysosomal oligosaccharide catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0009449", "name": "gamma-aminobutyric acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-888568 \"GABA synthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0009450", "name": "gamma-aminobutyric acid catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:4AMINOBUTMETAB-PWY", "Reactome:R-HSA-916853 \"Degradation of GABA\"" ], "previous": [ "MetaCyc:4AMINOBUTMETAB-PWY" ] } } }, { "id": "GO:0009615", "name": "response to virus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9824446 \"Viral Infection Pathways\"" ], "previous": "N/A" } } }, { "id": "GO:0009617", "name": "response to bacterium", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9824439 \"Bacterial Infection Pathways\"" ], "previous": "N/A" } } }, { "id": "GO:0009790", "name": "embryo development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5619507 \"Activation of HOX genes during differentiation\"", "Wikipedia:Embryogenesis" ], "previous": [ "Wikipedia:Embryogenesis" ] } } }, { "id": "GO:0009968", "name": "negative regulation of signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8849472 \"PTK6 Down-Regulation\"" ], "previous": "N/A" } } }, { "id": "GO:0010025", "name": "wax biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-282", "Reactome:R-HSA-9640463 \"Wax biosynthesis\"" ], "previous": [ "MetaCyc:PWY-282" ] } } }, { "id": "GO:0010038", "name": "response to metal ion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5660526 \"Response to metal ions\"" ], "previous": "N/A" } } }, { "id": "GO:0010142", "name": "farnesyl diphosphate biosynthetic process, mevalonate pathway", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:PWY-922" ] } } }, { "id": "GO:0010389", "name": "regulation of G2/M transition of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8854518 \"AURKA Activation by TPX2\"" ], "previous": "N/A" } } }, { "id": "GO:0010468", "name": "regulation of gene expression", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163767 \"PP2A-mediated dephosphorylation of key metabolic factors\"", "Reactome:R-HSA-9752946 \"Expression and translocation of olfactory receptors\"", "Wikipedia:Regulation_of_gene_expression" ], "previous": [ "Wikipedia:Regulation_of_gene_expression" ] } } }, { "id": "GO:0010510", "name": "regulation of acetyl-CoA biosynthetic process from pyruvate", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-204174 \"Regulation of pyruvate dehydrogenase (PDH) complex\"" ], "previous": "N/A" } } }, { "id": "GO:0010586", "name": "miRNA metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-203927 \"MicroRNA (miRNA) biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0010737", "name": "protein kinase A signaling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163358 \"PKA-mediated phosphorylation of key metabolic factors\"" ], "previous": "N/A" } } }, { "id": "GO:0010803", "name": "regulation of tumor necrosis factor-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5357905 \"Regulation of TNFR1 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0010999", "name": "regulation of eIF2 alpha phosphorylation by heme", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9648895 \"Response of EIF2AK1 (HRI) to heme deficiency\"" ], "previous": "N/A" } } }, { "id": "GO:0012501", "name": "programmed cell death", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5357801 \"Programmed Cell Death\"", "Wikipedia:Programmed_cell_death" ], "previous": [ "Wikipedia:Programmed_cell_death" ] } } }, { "id": "GO:0015012", "name": "heparan sulfate proteoglycan biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6558", "Reactome:R-HSA-2022928 \"HS-GAG biosynthesis\"", "RESID:AA0210" ], "previous": [ "MetaCyc:PWY-6558", "RESID:AA0210" ] } } }, { "id": "GO:0015671", "name": "oxygen transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8981607 \"Intracellular oxygen transport\"" ], "previous": "N/A" } } }, { "id": "GO:0015701", "name": "bicarbonate transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1475029 \"Reversible hydration of carbon dioxide\"", "Reactome:R-HSA-1480926 \"O2/CO2 exchange in erythrocytes\"", "Reactome:R-HSA-425381 \"Bicarbonate transporters\"" ], "previous": "N/A" } } }, { "id": "GO:0015721", "name": "bile acid and bile salt transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-159418 \"Recycling of bile acids and salts\"" ], "previous": "N/A" } } }, { "id": "GO:0015793", "name": "glycerol transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-432030 \"Transport of glycerol from adipocytes to the liver by Aquaporins\"" ], "previous": "N/A" } } }, { "id": "GO:0015798", "name": "myo-inositol transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429593 \"Inositol transporters\"" ], "previous": "N/A" } } }, { "id": "GO:0015889", "name": "cobalamin transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9758881 \"Uptake of dietary cobalamins into enterocytes\"", "Reactome:R-HSA-9758890 \"Transport of RCbl within the body\"" ], "previous": "N/A" } } }, { "id": "GO:0015909", "name": "long-chain fatty acid transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-804914 \"Transport of fatty acids\"" ], "previous": "N/A" } } }, { "id": "GO:0015914", "name": "phospholipid transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483196 \"PI and PC transport between ER and Golgi membranes\"" ], "previous": "N/A" } } }, { "id": "GO:0015937", "name": "coenzyme A biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196783 \"Coenzyme A biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0015939", "name": "pantothenate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-199220 \"Vitamin B5 (pantothenate) metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0015949", "name": "nucleobase-containing small molecule interconversion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-499943 \"Interconversion of nucleotide di- and triphosphates\"" ], "previous": "N/A" } } }, { "id": "GO:0016032", "name": "viral process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162906 \"HIV Infection\"", "Wikipedia:Viral_life_cycle" ], "previous": [ "Wikipedia:Viral_life_cycle" ] } } }, { "id": "GO:0016055", "name": "Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-195721 \"Signaling by WNT\"" ], "previous": "N/A" } } }, { "id": "GO:0016056", "name": "G protein-coupled opsin signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2514856 \"The phototransduction cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0016070", "name": "RNA metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8953854 \"Metabolism of RNA\"" ], "previous": "N/A" } } }, { "id": "GO:0016071", "name": "mRNA metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-111367 \"SLBP independent Processing of Histone Pre-mRNAs\"" ], "previous": "N/A" } } }, { "id": "GO:0016078", "name": "tRNA decay", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9708296 \"tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0016125", "name": "sterol metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211976 \"Endogenous sterols\"" ], "previous": "N/A" } } }, { "id": "GO:0016197", "name": "endosomal transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-917729 \"Endosomal Sorting Complex Required For Transport (ESCRT)\"" ], "previous": "N/A" } } }, { "id": "GO:0016226", "name": "iron-sulfur cluster assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1362409 \"Mitochondrial iron-sulfur cluster biogenesis\"", "Reactome:R-HSA-2564830 \"Cytosolic iron-sulfur cluster assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0016236", "name": "macroautophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1632852 \"Macroautophagy\"", "Reactome:R-HSA-5205685 \"PINK1-PRKN Mediated Mitophagy\"", "Reactome:R-HSA-8934903 \"Receptor Mediated Mitophagy\"" ], "previous": "N/A" } } }, { "id": "GO:0016255", "name": "attachment of GPI anchor to protein", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162791 \"Attachment of GPI anchor to uPAR\"" ], "previous": "N/A" } } }, { "id": "GO:0016259", "name": "selenocysteine metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2408522 \"Selenoamino acid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0016264", "name": "gap junction assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-190861 \"Gap junction assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0016266", "name": "O-glycan processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-913709 \"O-linked glycosylation of mucins\"" ], "previous": "N/A" } } }, { "id": "GO:0016485", "name": "protein processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9033500 \"TYSND1 cleaves peroxisomal proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0016486", "name": "peptide hormone processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-209952 \"Peptide hormone biosynthesis\"", "Reactome:R-HSA-400508 \"Incretin synthesis, secretion, and inactivation\"", "Reactome:R-HSA-422085 \"Synthesis, secretion, and deacylation of Ghrelin\"" ], "previous": "N/A" } } }, { "id": "GO:0016554", "name": "cytidine to uridine editing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72200 \"mRNA Editing" ], "previous": "N/A" } } }, { "id": "GO:0016556", "name": "mRNA modification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75072 \"mRNA Editing\"" ], "previous": "N/A" } } }, { "id": "GO:0016567", "name": "protein ubiquitination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8852135 \"Protein ubiquitination\"" ], "previous": "N/A" } } }, { "id": "GO:0016579", "name": "protein deubiquitination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5688426 \"Deubiquitination\"" ], "previous": "N/A" } } }, { "id": "GO:0016601", "name": "Rac protein signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-428540 \"Activation of RAC1\"" ], "previous": "N/A" } } }, { "id": "GO:0016925", "name": "protein sumoylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2990846 \"SUMOylation\"", "Wikipedia:SUMO_protein" ], "previous": [ "Wikipedia:SUMO_protein" ] } } }, { "id": "GO:0017183", "name": "protein histidyl modification to diphthamide", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5358493 \"Synthesis of diphthamide-EEF2\"", "RESID:AA0040" ], "previous": [ "RESID:AA0040" ] } } }, { "id": "GO:0017187", "name": "peptidyl-glutamic acid carboxylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-159854 \"Gamma-carboxylation, transport, and amino-terminal cleavage of proteins\"", "RESID:AA0032" ], "previous": [ "RESID:AA0032" ] } } }, { "id": "GO:0018126", "name": "protein hydroxylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9629569 \"Protein hydroxylation\"" ], "previous": "N/A" } } }, { "id": "GO:0018146", "name": "keratan sulfate biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2022854 \"Keratan sulfate biosynthesis\"", "RESID:AA0247" ], "previous": [ "RESID:AA0247" ] } } }, { "id": "GO:0018279", "name": "protein N-linked glycosylation via asparagine", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162699 \"Synthesis of dolichyl-phosphate mannose\"", "Reactome:R-HSA-446203 \"Asparagine N-linked glycosylation\"", "Reactome:R-HSA-480985 \"Synthesis of dolichyl-phosphate-glucose\"" ], "previous": "N/A" } } }, { "id": "GO:0018868", "name": "2-aminobenzenesulfonate metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:abs" ] } } }, { "id": "GO:0018873", "name": "atrazine metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:atr" ] } } }, { "id": "GO:0018874", "name": "benzoate metabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:benz2" ], "previous": [ "MetaCyc:P321-PWY", "UM-BBD_pathwayID:benz2" ] } } }, { "id": "GO:0018875", "name": "anaerobic benzoate metabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:benz" ], "previous": [ "MetaCyc:CENTBENZCOA-PWY", "UM-BBD_pathwayID:benz" ] } } }, { "id": "GO:0018882", "name": "(+)-camphor metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:cam" ] } } }, { "id": "GO:0018901", "name": "2,4-dichlorophenoxyacetic acid metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:2\\,4-d" ] } } }, { "id": "GO:0018952", "name": "parathion metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:pthn" ] } } }, { "id": "GO:0019058", "name": "viral life cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162588 \"Budding and maturation of HIV virion\"", "Reactome:R-HSA-168255 \"Influenza Infection\"", "Reactome:R-HSA-9609646 \"HCMV Infection\"" ], "previous": "N/A" } } }, { "id": "GO:0019060", "name": "intracellular transport of viral protein in host cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168874 \"Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus\"" ], "previous": "N/A" } } }, { "id": "GO:0019061", "name": "uncoating of virus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162585 \"Uncoating of the HIV Virion\"", "Reactome:R-HSA-168336 \"Uncoating of the Influenza Virion\"" ], "previous": "N/A" } } }, { "id": "GO:0019064", "name": "fusion of virus membrane with host plasma membrane", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168288 \"Fusion of the Influenza Virion to the Host Cell Endosome\"", "VZ:987 \"Fusion of virus membrane with host cell membrane\"" ], "previous": [ "VZ:987 \"Fusion of virus membrane with host cell membrane\"" ] } } }, { "id": "GO:0019065", "name": "receptor-mediated endocytosis of virus by host cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168275 \"Entry of Influenza Virion into Host Cell via Endocytosis\"" ], "previous": "N/A" } } }, { "id": "GO:0019068", "name": "virion assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168302 \"Budding\"", "Reactome:R-HSA-168316 \"Assembly of Viral Components at the Budding Site\"", "Reactome:R-HSA-175474 \"Assembly Of The HIV Virion\"" ], "previous": "N/A" } } }, { "id": "GO:0019070", "name": "viral genome maturation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168330 \"Viral RNP Complexes in the Host Cell Nucleus\"" ], "previous": "N/A" } } }, { "id": "GO:0019072", "name": "viral genome packaging", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168303 \"Packaging of Eight RNA Segments\"" ], "previous": "N/A" } } }, { "id": "GO:0019076", "name": "viral release from host cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168298 \"Release\"", "VZ:1076 \"Virus exit from host cell\"" ], "previous": [ "VZ:1076 \"Virus exit from host cell\"" ] } } }, { "id": "GO:0019081", "name": "viral translation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9683701 \"Translation of Structural Proteins\"", "Reactome:R-HSA-9694635 \"Translation of Structural Proteins\"", "Reactome:R-HSA-9727281 \"Translation of Accessory Proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0019082", "name": "viral protein processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-171286 \"Synthesis and processing of ENV and VPU\"", "Reactome:R-HSA-174495 \"Synthesis And Processing Of GAG, GAGPOL Polyproteins\"", "Reactome:R-HSA-9683610 \"Maturation of nucleoprotein\"", "Reactome:R-HSA-9683612 \"Maturation of protein M\"", "Reactome:R-HSA-9683673 \"Maturation of protein 3a\"", "Reactome:R-HSA-9683686 \"Maturation of spike protein\"", "Reactome:R-HSA-9694548 \"Maturation of spike protein\"", "Reactome:R-HSA-9694594 \"Maturation of protein M\"", "Reactome:R-HSA-9694631 \"Maturation of nucleoprotein\"", "Reactome:R-HSA-9694719 \"Maturation of protein 3a\"" ], "previous": "N/A" } } }, { "id": "GO:0019083", "name": "viral transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167172 \"Transcription of the HIV genome\"", "Reactome:R-HSA-168273 \"Influenza Viral RNA Transcription and Replication\"" ], "previous": "N/A" } } }, { "id": "GO:0019216", "name": "regulation of lipid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2426168 \"Activation of gene expression by SREBF (SREBP)\"", "Reactome:R-HSA-400206 \"Regulation of lipid metabolism by PPARalpha\"" ], "previous": "N/A" } } }, { "id": "GO:0019221", "name": "cytokine-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-449147 \"Signaling by Interleukins\"", "Reactome:R-HSA-913531 \"Interferon Signaling\"", "Reactome:R-HSA-9607240 \"FLT3 Signaling\"", "Reactome:R-HSA-9674555 \"Signaling by CSF3 (G-CSF)\"", "Reactome:R-HSA-9680350 \"Signaling by CSF1 (M-CSF) in myeloid cells\"" ], "previous": "N/A" } } }, { "id": "GO:0019222", "name": "regulation of metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1989781 \"PPARA activates gene expression\"" ], "previous": "N/A" } } }, { "id": "GO:0019287", "name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-922" ], "previous": "N/A" } } }, { "id": "GO:0019339", "name": "parathion catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PARATHION-DEGRADATION-PWY", "UM-BBD_pathwayID:pthn" ], "previous": [ "MetaCyc:PARATHION-DEGRADATION-PWY" ] } } }, { "id": "GO:0019346", "name": "transsulfuration", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-801", "Reactome:R-HSA-1614603 \"Cysteine formation from homocysteine\"", "Wikipedia:Transsulfuration_pathway" ], "previous": [ "MetaCyc:PWY-801", "Wikipedia:Transsulfuration_pathway" ] } } }, { "id": "GO:0019369", "name": "arachidonate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142753 \"Arachidonate metabolism\"", "Reactome:R-HSA-426048 \"Arachidonate production from DAG\"", "Wikipedia:Arachidonic_acid" ], "previous": [ "Wikipedia:Arachidonic_acid" ] } } }, { "id": "GO:0019372", "name": "lipoxygenase pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142688 \"Synthesis of 5-eicosatetraenoic acids\"", "Reactome:R-HSA-2142712 \"Synthesis of 12-eicosatetraenoic acid derivatives\"", "Reactome:R-HSA-2142770 \"Synthesis of 15-eicosatetraenoic acid derivatives\"", "Reactome:R-HSA-9025094 \"Biosynthesis of DPAn-3 SPMs\"" ], "previous": "N/A" } } }, { "id": "GO:0019373", "name": "epoxygenase P450 pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142670 \"Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)\"" ], "previous": "N/A" } } }, { "id": "GO:0019381", "name": "atrazine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5724", "UM-BBD_pathwayID:atr" ], "previous": [ "MetaCyc:PWY-5724" ] } } }, { "id": "GO:0019383", "name": "(+)-camphor catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:P601-PWY", "UM-BBD_pathwayID:cam" ], "previous": [ "MetaCyc:P601-PWY" ] } } }, { "id": "GO:0019391", "name": "glucuronoside catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLUCUROCAT-PWY" ], "previous": "N/A" } } }, { "id": "GO:0019432", "name": "triglyceride biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:TRIGLSYN-PWY", "Reactome:R-HSA-75109 \"Triglyceride biosynthesis\"" ], "previous": [ "MetaCyc:TRIGLSYN-PWY" ] } } }, { "id": "GO:0019433", "name": "triglyceride catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:LIPAS-PWY", "Reactome:R-HSA-163560 \"Triglyceride catabolism\"" ], "previous": [ "MetaCyc:LIPAS-PWY" ] } } }, { "id": "GO:0019490", "name": "2-aminobenzenesulfonate desulfonation", "changes": { "xrefs": { "current": [ "MetaCyc:2ASDEG-PWY", "UM-BBD_pathwayID:abs" ], "previous": [ "MetaCyc:2ASDEG-PWY" ] } } }, { "id": "GO:0019509", "name": "L-methionine salvage from methylthioadenosine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-4361", "Reactome:R-HSA-1237112 \"Methionine salvage pathway\"" ], "previous": [ "MetaCyc:PWY-4361" ] } } }, { "id": "GO:0019518", "name": "L-threonine catabolic process to glycine", "changes": { "xrefs": { "current": [ "MetaCyc:THREONINE-DEG2-PWY", "Reactome:R-HSA-8849175 \"Threonine catabolism\"" ], "previous": [ "MetaCyc:THREONINE-DEG2-PWY" ] } } }, { "id": "GO:0019538", "name": "protein metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-392499 \"Metabolism of proteins\"", "Wikipedia:Protein_metabolism" ], "previous": [ "Wikipedia:Protein_metabolism" ] } } }, { "id": "GO:0019626", "name": "short-chain fatty acid catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:ACETOACETATE-DEG-PWY", "Reactome:R-HSA-71032 \"Propionyl-CoA catabolism\"" ], "previous": [ "MetaCyc:ACETOACETATE-DEG-PWY" ] } } }, { "id": "GO:0019640", "name": "D-glucuronate catabolic process to D-xylulose 5-phosphate", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5661270 \"Formation of xylulose-5-phosphate\"" ], "previous": "N/A" } } }, { "id": "GO:0019664", "name": "mixed acid fermentation", "changes": { "xrefs": { "current": [ "MetaCyc:FERMENTATION-PWY", "Wikipedia:Mixed_acid_fermentation" ], "previous": [ "Wikipedia:Mixed_acid_fermentation" ] } } }, { "id": "GO:0019674", "name": "NAD metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196807 \"Nicotinate metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0019730", "name": "antimicrobial humoral response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6803157 \"Antimicrobial peptides\"" ], "previous": "N/A" } } }, { "id": "GO:0019752", "name": "carboxylic acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-389661 \"Glyoxylate metabolism and glycine degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0019852", "name": "L-ascorbic acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196836 \"Vitamin C (ascorbate) metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0019886", "name": "antigen processing and presentation of exogenous peptide antigen via MHC class II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2132295 \"MHC class II antigen presentation\"" ], "previous": "N/A" } } }, { "id": "GO:0019985", "name": "translesion synthesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73893 \"DNA Damage Bypass\"" ], "previous": "N/A" } } }, { "id": "GO:0022400", "name": "regulation of opsin-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2514859 \"Inactivation, recovery and regulation of the phototransduction cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0022617", "name": "extracellular matrix disassembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1474228 \"Degradation of the extracellular matrix\"" ], "previous": "N/A" } } }, { "id": "GO:0022904", "name": "respiratory electron transport chain", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-611105 \"Respiratory electron transport\"", "Wikipedia:Electron_transfer" ], "previous": [ "Wikipedia:Electron_transfer" ] } } }, { "id": "GO:0030049", "name": "muscle filament sliding", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-390522 \"Striated Muscle Contraction\"" ], "previous": "N/A" } } }, { "id": "GO:0030070", "name": "insulin processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-264876 \"Insulin processing\"" ], "previous": "N/A" } } }, { "id": "GO:0030091", "name": "protein repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5676934 \"Protein repair\"" ], "previous": "N/A" } } }, { "id": "GO:0030111", "name": "regulation of Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939256 \"RUNX1 regulates transcription of genes involved in WNT signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0030148", "name": "sphingolipid biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5129", "Reactome:R-HSA-1660661 \"Sphingolipid de novo biosynthesis\"" ], "previous": [ "MetaCyc:PWY-5129" ] } } }, { "id": "GO:0030149", "name": "sphingolipid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9845614 \"Sphingolipid catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0030168", "name": "platelet activation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-392023 \"Adrenaline signalling through Alpha-2 adrenergic receptor\"", "Reactome:R-HSA-392170 \"ADP signalling through P2Y purinoceptor 12\"", "Reactome:R-HSA-418592 \"ADP signalling through P2Y purinoceptor 1\"", "Reactome:R-HSA-76002 \"Platelet activation, signaling and aggregation\"" ], "previous": "N/A" } } }, { "id": "GO:0030198", "name": "extracellular matrix organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1474244 \"Extracellular matrix organization\"" ], "previous": "N/A" } } }, { "id": "GO:0030199", "name": "collagen fibril organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1474290 \"Collagen formation\"", "Reactome:R-HSA-2214320 \"Anchoring fibril formation\"", "Reactome:R-HSA-2243919 \"Crosslinking of collagen fibrils\"" ], "previous": "N/A" } } }, { "id": "GO:0030200", "name": "heparan sulfate proteoglycan catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2024096 \"HS-GAG degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0030203", "name": "glycosaminoglycan metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1630316 \"Glycosaminoglycan metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0030204", "name": "chondroitin sulfate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1793185 \"Chondroitin sulfate/dermatan sulfate metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0030206", "name": "chondroitin sulfate biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6567", "Reactome:R-HSA-2022870 \"Chondroitin sulfate biosynthesis\"" ], "previous": [ "MetaCyc:PWY-6567" ] } } }, { "id": "GO:0030208", "name": "dermatan sulfate biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6568", "Reactome:R-HSA-2022923 \"Dermatan sulfate biosynthesis\"" ], "previous": [ "MetaCyc:PWY-6568" ] } } }, { "id": "GO:0030212", "name": "hyaluronan metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142845 \"Hyaluronan metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0030213", "name": "hyaluronan biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142850 \"Hyaluronan biosynthesis and export\"" ], "previous": "N/A" } } }, { "id": "GO:0030214", "name": "hyaluronan catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7645", "Reactome:R-HSA-2160916 \"Hyaluronan uptake and degradation\"" ], "previous": [ "MetaCyc:PWY-7645" ] } } }, { "id": "GO:0030422", "name": "siRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-426486 \"Small interfering RNA (siRNA) biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0030449", "name": "regulation of complement activation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-977606 \"Regulation of Complement cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0030509", "name": "BMP signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-201451 \"Signaling by BMP\"" ], "previous": "N/A" } } }, { "id": "GO:0030512", "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2173788 \"Downregulation of TGF-beta receptor signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0030522", "name": "intracellular receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9024446 \"NR1H2 and NR1H3-mediated signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0030574", "name": "collagen catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1442490 \"Collagen degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0030851", "name": "granulocyte differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9616222 \"Transcriptional regulation of granulopoiesis\"" ], "previous": "N/A" } } }, { "id": "GO:0030968", "name": "endoplasmic reticulum unfolded protein response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381119 \"Unfolded Protein Response (UPR)\"" ], "previous": "N/A" } } }, { "id": "GO:0031018", "name": "endocrine pancreas development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-186712 \"Regulation of beta-cell development\"" ], "previous": "N/A" } } }, { "id": "GO:0031047", "name": "regulatory ncRNA-mediated gene silencing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211000 \"Gene Silencing by RNA\"" ], "previous": "N/A" } } }, { "id": "GO:0031124", "name": "mRNA 3'-end processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-72187 \"mRNA 3'-end processing\"", "Reactome:R-HSA-75067 \"Processing of Capped Intronless Pre-mRNA\"" ], "previous": "N/A" } } }, { "id": "GO:0031145", "name": "anaphase-promoting complex-dependent catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-174048 \"APC/C:Cdc20 mediated degradation of Cyclin B\"", "Reactome:R-HSA-174143 \"APC/C-mediated degradation of cell cycle proteins\"", "Reactome:R-HSA-174154 \"APC/C:Cdc20 mediated degradation of Securin\"", "Reactome:R-HSA-174184 \"Cdc20:Phospho-APC/C mediated degradation of Cyclin A\"" ], "previous": "N/A" } } }, { "id": "GO:0031293", "name": "membrane protein intracellular domain proteolysis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193692 \"Regulated proteolysis of p75NTR\"" ], "previous": "N/A" } } }, { "id": "GO:0031295", "name": "T cell costimulation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-388841 \"Costimulation by the CD28 family\"" ], "previous": "N/A" } } }, { "id": "GO:0031342", "name": "negative regulation of cell killing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664433 \"Leishmania parasite growth and survival\"" ], "previous": "N/A" } } }, { "id": "GO:0031343", "name": "positive regulation of cell killing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664420 \"Killing mechanisms\"" ], "previous": "N/A" } } }, { "id": "GO:0031424", "name": "keratinization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6805567 \"Keratinization\"" ], "previous": "N/A" } } }, { "id": "GO:0031507", "name": "heterochromatin formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5334118 \"DNA methylation\"" ], "previous": "N/A" } } }, { "id": "GO:0031581", "name": "hemidesmosome assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446107 \"Type I hemidesmosome assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0032024", "name": "positive regulation of insulin secretion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-399997 \"Acetylcholine regulates insulin secretion\"" ], "previous": "N/A" } } }, { "id": "GO:0032049", "name": "cardiolipin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5269", "Reactome:R-HSA-1483076 \"Synthesis of CL\"" ], "previous": [ "MetaCyc:PWY-5269" ] } } }, { "id": "GO:0032201", "name": "telomere maintenance via semi-conservative replication", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-174417 \"Telomere C-strand (Lagging Strand) Synthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0032259", "name": "methylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156581 \"Methylation\"", "Wikipedia:Methylation" ], "previous": [ "Wikipedia:Methylation" ] } } }, { "id": "GO:0032324", "name": "molybdopterin cofactor biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:Molybdenum-Cofactor-Biosynthesis", "Reactome:R-HSA-947581 \"Molybdenum cofactor biosynthesis\"" ], "previous": [ "MetaCyc:Molybdenum-Cofactor-Biosynthesis" ] } } }, { "id": "GO:0032455", "name": "nerve growth factor processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167060 \"NGF processing\"" ], "previous": "N/A" } } }, { "id": "GO:0032479", "name": "regulation of type I interferon production", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3134975 \"Regulation of innate immune responses to cytosolic DNA\"" ], "previous": "N/A" } } }, { "id": "GO:0032480", "name": "negative regulation of type I interferon production", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-936440 \"Negative regulators of DDX58/IFIH1 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0032481", "name": "positive regulation of type I interferon production", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1834949 \"Cytosolic sensors of pathogen-associated DNA\"" ], "previous": "N/A" } } }, { "id": "GO:0032543", "name": "mitochondrial translation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5368287 \"Mitochondrial translation\"" ], "previous": "N/A" } } }, { "id": "GO:0032802", "name": "low-density lipoprotein particle receptor catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8866427 \"VLDLR internalisation and degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0032981", "name": "mitochondrial respiratory chain complex I assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6799198 \"Complex I biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0033146", "name": "regulation of intracellular estrogen receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8931987 \"RUNX1 regulates estrogen receptor mediated transcription\"" ], "previous": "N/A" } } }, { "id": "GO:0033209", "name": "tumor necrosis factor-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5668541 \"TNFR2 non-canonical NF-kB pathway\"", "Reactome:R-HSA-75893 \"TNF signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0033214", "name": "siderophore-dependent iron import into cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222449 \"Mtb iron assimilation by chelation\"" ], "previous": "N/A" } } }, { "id": "GO:0033271", "name": "myo-inositol phosphate transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1855156 \"IPs transport between ER lumen and nucleus\"", "Reactome:R-HSA-1855170 \"IPs transport between nucleus and cytosol\"", "Reactome:R-HSA-1855184 \"IPs transport between cytosol and ER lumen\"", "Reactome:R-HSA-1855192 \"IPs transport between nucleus and ER lumen\"", "Reactome:R-HSA-1855196 \"IP3 and IP4 transport between cytosol and nucleus\"", "Reactome:R-HSA-1855215 \"IPs transport between ER lumen and cytosol\"", "Reactome:R-HSA-1855229 \"IP6 and IP7 transport between cytosol and nucleus\"" ], "previous": "N/A" } } }, { "id": "GO:0033387", "name": "putrescine biosynthetic process from arginine, via ornithine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-46" ], "previous": "N/A" } } }, { "id": "GO:0033389", "name": "putrescine biosynthetic process from arginine, via agmatine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-40" ], "previous": "N/A" } } }, { "id": "GO:0033390", "name": "putrescine biosynthetic process from arginine via N-carbamoylputrescine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-43" ], "previous": "N/A" } } }, { "id": "GO:0033489", "name": "cholesterol biosynthetic process via desmosterol", "changes": { "xrefs": { "current": [ "MetaCyc:PWY66-4", "Reactome:R-HSA-6807047 \"Cholesterol biosynthesis via desmosterol\"" ], "previous": [ "MetaCyc:PWY66-4" ] } } }, { "id": "GO:0033490", "name": "cholesterol biosynthetic process via lathosterol", "changes": { "xrefs": { "current": [ "MetaCyc:PWY66-341", "Reactome:R-HSA-6807062 \"Cholesterol biosynthesis via lathosterol\"" ], "previous": [ "MetaCyc:PWY66-341" ] } } }, { "id": "GO:0033499", "name": "galactose catabolic process via UDP-galactose", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6317", "Reactome:R-HSA-70370 \"Galactose catabolism\"" ], "previous": [ "MetaCyc:PWY-6317" ] } } }, { "id": "GO:0033540", "name": "fatty acid beta-oxidation using acyl-CoA oxidase", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5136", "Reactome:R-HSA-389887 \"Beta-oxidation of pristanoyl-CoA\"", "Reactome:R-HSA-390247 \"Beta-oxidation of very long chain fatty acids\"" ], "previous": [ "MetaCyc:PWY-5136" ] } } }, { "id": "GO:0033554", "name": "cellular response to stress", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2262752 \"Cellular responses to stress\"" ], "previous": "N/A" } } }, { "id": "GO:0033559", "name": "unsaturated fatty acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2046104 \"alpha-linolenic (omega3) and linoleic (omega6) acid metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0033572", "name": "transferrin transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-917977 \"Transferrin endocytosis and recycling\"" ], "previous": "N/A" } } }, { "id": "GO:0033617", "name": "mitochondrial cytochrome c oxidase assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9864848 \"Complex IV assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0033668", "name": "symbiont-mediated suppression of host apoptosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9635465 \"Suppression of apoptosis\"" ], "previous": "N/A" } } }, { "id": "GO:0034080", "name": "CENP-A containing chromatin assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-606279 \"Deposition of new CENPA-containing nucleosomes at the centromere\"" ], "previous": "N/A" } } }, { "id": "GO:0034097", "name": "response to cytokine", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9645135 \"STAT5 Activation\"" ], "previous": "N/A" } } }, { "id": "GO:0034110", "name": "regulation of homotypic cell-cell adhesion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9759476 \"Regulation of Homotypic Cell-Cell Adhesion\"" ], "previous": "N/A" } } }, { "id": "GO:0034121", "name": "regulation of toll-like receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9860276 \"SLC15A4:TASL-dependent IRF5 activation\"" ], "previous": "N/A" } } }, { "id": "GO:0034134", "name": "toll-like receptor 2 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-181438 \"Toll Like Receptor 2 (TLR2) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034138", "name": "toll-like receptor 3 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168164 \"Toll Like Receptor 3 (TLR3) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034142", "name": "toll-like receptor 4 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166016 \"Toll Like Receptor 4 (TLR4) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034146", "name": "toll-like receptor 5 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168176 \"Toll Like Receptor 5 (TLR5) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034162", "name": "toll-like receptor 9 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168138 \"Toll Like Receptor 9 (TLR9) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034166", "name": "toll-like receptor 10 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168142 \"Toll Like Receptor 10 (TLR10) Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0034198", "name": "cellular response to amino acid starvation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9633012 \"Response of EIF2AK4 (GCN2) to amino acid deficiency\"", "Reactome:R-HSA-9639288 \"Amino acids regulate mTORC1\"" ], "previous": "N/A" } } }, { "id": "GO:0034199", "name": "activation of protein kinase A activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163615 \"PKA activation\"" ], "previous": "N/A" } } }, { "id": "GO:0034220", "name": "monoatomic ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-983712 \"Ion channel transport\"" ], "previous": "N/A" } } }, { "id": "GO:0034329", "name": "cell junction assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-446728 \"Cell junction organization\"" ], "previous": "N/A" } } }, { "id": "GO:0034332", "name": "adherens junction organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-418990 \"Adherens junctions interactions\"" ], "previous": "N/A" } } }, { "id": "GO:0034356", "name": "NAD biosynthesis via nicotinamide riboside salvage pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-197264 \"Nicotinamide salvaging\"" ], "previous": "N/A" } } }, { "id": "GO:0034369", "name": "plasma lipoprotein particle remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963899 \"Plasma lipoprotein remodeling\"" ], "previous": "N/A" } } }, { "id": "GO:0034371", "name": "chylomicron remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963901 \"Chylomicron remodeling\"" ], "previous": "N/A" } } }, { "id": "GO:0034374", "name": "low-density lipoprotein particle remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964041 \"LDL remodeling\"" ], "previous": "N/A" } } }, { "id": "GO:0034375", "name": "high-density lipoprotein particle remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964058 \"HDL remodeling\"" ], "previous": "N/A" } } }, { "id": "GO:0034377", "name": "plasma lipoprotein particle assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963898 \"Plasma lipoprotein assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0034378", "name": "chylomicron assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963888 \"Chylomicron assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0034379", "name": "very-low-density lipoprotein particle assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8866423 \"VLDL assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0034380", "name": "high-density lipoprotein particle assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963896 \"HDL assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0034381", "name": "plasma lipoprotein particle clearance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964043 \"Plasma lipoprotein clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0034382", "name": "chylomicron remnant clearance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964026 \"Chylomicron clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0034383", "name": "low-density lipoprotein particle clearance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964038 \"LDL clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0034384", "name": "high-density lipoprotein particle clearance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964011 \"HDL clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0034389", "name": "lipid droplet organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964572 \"Lipid particle organization\"" ], "previous": "N/A" } } }, { "id": "GO:0034404", "name": "nucleobase-containing small molecule biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8956320 \"Nucleotide biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0034447", "name": "very-low-density lipoprotein particle clearance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8964046 \"VLDL clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0034551", "name": "mitochondrial respiratory chain complex III assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9865881 \"Complex III assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0034587", "name": "piRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5601884 \"PIWI-interacting RNA (piRNA) biogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0034599", "name": "cellular response to oxidative stress", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3299685 \"Detoxification of Reactive Oxygen Species\"", "Reactome:R-HSA-9707564 \"Cytoprotection by HMOX1\"" ], "previous": "N/A" } } }, { "id": "GO:0034605", "name": "cellular response to heat", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3371556 \"Cellular response to heat stress\"" ], "previous": "N/A" } } }, { "id": "GO:0034656", "name": "nucleobase-containing small molecule catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8956319 \"Nucleotide catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0035019", "name": "somatic stem cell population maintenance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-452723 \"Transcriptional regulation of pluripotent stem cells\"" ], "previous": "N/A" } } }, { "id": "GO:0035036", "name": "sperm-egg recognition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1300642 \"Sperm Motility And Taxes\"", "Reactome:R-HSA-2534343 \"Interaction With Cumulus Cells And The Zona Pellucida\"" ], "previous": "N/A" } } }, { "id": "GO:0035194", "name": "regulatory ncRNA-mediated post-transcriptional gene silencing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-426496 \"Post-transcriptional silencing by small RNAs\"", "Wikipedia:RNA_interference" ], "previous": [ "Wikipedia:RNA_interference" ] } } }, { "id": "GO:0035195", "name": "miRNA-mediated post-transcriptional gene silencing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9759811 \"Regulation of CDH11 mRNA translation by microRNAs\"" ], "previous": "N/A" } } }, { "id": "GO:0035329", "name": "hippo signaling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2028269 \"Signaling by Hippo\"" ], "previous": "N/A" } } }, { "id": "GO:0035338", "name": "long-chain fatty-acyl-CoA biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75876 \"Synthesis of very long-chain fatty acyl-CoAs\"" ], "previous": "N/A" } } }, { "id": "GO:0035567", "name": "non-canonical Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3858494 \"Beta-catenin independent WNT signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0035590", "name": "purinergic nucleotide receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9660826 \"Purinergic signaling in leishmaniasis infection\"" ], "previous": "N/A" } } }, { "id": "GO:0035627", "name": "ceramide transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9845576 \"Glycosphingolipid transport\"" ], "previous": "N/A" } } }, { "id": "GO:0035655", "name": "interleukin-18-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9012546 \"Interleukin-18 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0035666", "name": "TRIF-dependent toll-like receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9013973 \"TICAM1-dependent activation of IRF3/IRF7\"", "Reactome:R-HSA-937061 \"TRIF (TICAM1)-mediated TLR4 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0035694", "name": "mitochondrial protein catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9837999 \"Mitochondrial protein degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0035722", "name": "interleukin-12-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-447115 \"Interleukin-12 family signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0035723", "name": "interleukin-15-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8983432 \"Interleukin-15 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0035735", "name": "intraciliary transport involved in cilium assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5620924 \"Intraflagellar transport\"" ], "previous": "N/A" } } }, { "id": "GO:0035872", "name": "nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168643 \"Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways\"" ], "previous": "N/A" } } }, { "id": "GO:0035965", "name": "cardiolipin acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482798 \"Acyl chain remodeling of CL\"" ], "previous": "N/A" } } }, { "id": "GO:0035973", "name": "aggrephagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9646399 \"Aggrephagy\"" ], "previous": "N/A" } } }, { "id": "GO:0036066", "name": "protein O-linked fucosylation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5173214 \"O-glycosylation of TSR domain-containing proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0036109", "name": "alpha-linolenic acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2046106 \"alpha-linolenic acid (ALA) metabolism\"", "Wikipedia:Linoleic_acid" ], "previous": [ "Wikipedia:Linoleic_acid" ] } } }, { "id": "GO:0036148", "name": "phosphatidylglycerol acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482925 \"Acyl chain remodelling of PG\"" ], "previous": "N/A" } } }, { "id": "GO:0036149", "name": "phosphatidylinositol acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482922 \"Acyl chain remodelling of PI\"" ], "previous": "N/A" } } }, { "id": "GO:0036150", "name": "phosphatidylserine acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482801 \"Acyl chain remodelling of PS\"" ], "previous": "N/A" } } }, { "id": "GO:0036151", "name": "phosphatidylcholine acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482788 \"Acyl chain remodelling of PC\"" ], "previous": "N/A" } } }, { "id": "GO:0036152", "name": "phosphatidylethanolamine acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482839 \"Acyl chain remodelling of PE\"" ], "previous": "N/A" } } }, { "id": "GO:0036155", "name": "acylglycerol acyl-chain remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1482883 \"Acyl chain remodeling of DAG and TAG\"" ], "previous": "N/A" } } }, { "id": "GO:0036297", "name": "interstrand cross-link repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6783310 \"Fanconi Anemia Pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0036388", "name": "pre-replicative complex assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-68867 \"Assembly of the pre-replicative complex\"" ], "previous": "N/A" } } }, { "id": "GO:0036498", "name": "IRE1-mediated unfolded protein response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381070 \"IRE1alpha activates chaperones\"" ], "previous": "N/A" } } }, { "id": "GO:0036499", "name": "PERK-mediated unfolded protein response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381042 \"PERK regulates gene expression\"" ], "previous": "N/A" } } }, { "id": "GO:0036500", "name": "ATF6-mediated unfolded protein response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381033 \"ATF6 (ATF6-alpha) activates chaperones\"" ], "previous": "N/A" } } }, { "id": "GO:0038020", "name": "insulin receptor recycling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-77387 \"Insulin receptor recycling\"" ], "previous": "N/A" } } }, { "id": "GO:0038061", "name": "non-canonical NF-kappaB signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5676590 \"NIK-->noncanonical NF-kB signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038066", "name": "p38MAPK cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-450302 \"activated TAK1 mediates p38 MAPK activation\"" ], "previous": "N/A" } } }, { "id": "GO:0038095", "name": "Fc-epsilon receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2454202 \"Fc epsilon receptor (FCERI) signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038096", "name": "Fc-gamma receptor signaling pathway involved in phagocytosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2029480 \"Fcgamma receptor (FCGR) dependent phagocytosis\"", "Reactome:R-HSA-9664422 \"FCGR3A-mediated phagocytosis\"" ], "previous": "N/A" } } }, { "id": "GO:0038110", "name": "interleukin-2-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9020558 \"Interleukin-2 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038111", "name": "interleukin-7-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1266695 \"Interleukin-7 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038113", "name": "interleukin-9-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8985947 \"Interleukin-9 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038114", "name": "interleukin-21-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9020958 \"Interleukin-21 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038123", "name": "toll-like receptor TLR1:TLR2 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168179 \"Toll Like Receptor TLR1:TLR2 Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0038124", "name": "toll-like receptor TLR6:TLR2 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168188 \"Toll Like Receptor TLR6:TLR2 Cascade\"" ], "previous": "N/A" } } }, { "id": "GO:0038128", "name": "ERBB2 signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1227986 \"Signaling by ERBB2\"" ], "previous": "N/A" } } }, { "id": "GO:0038155", "name": "interleukin-23-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9020933 \"Interleukin-23 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0038162", "name": "erythropoietin-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9006335 \"Signaling by Erythropoietin\"" ], "previous": "N/A" } } }, { "id": "GO:0038172", "name": "interleukin-33-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9014843 \"Interleukin-33 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0039524", "name": "symbiont-mediated suppression of host mRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168315 \"Inhibition of Host mRNA Processing and RNA Silencing\"", "VZ:903 \"Inhibition of host pre-mRNA processing by virus\"" ], "previous": [ "VZ:903 \"Inhibition of host pre-mRNA processing by virus\"" ] } } }, { "id": "GO:0039585", "name": "PKR/eIFalpha signaling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9833482 \"PKR-mediated signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0039587", "name": "symbiont-mediated-mediated suppression of host tetherin activity", "changes": { "xrefs": { "current": [ "VZ:665" ], "previous": "N/A" } } }, { "id": "GO:0039673", "name": "symbiont-mediated suppression of host dendritic cell mediated immune response", "changes": { "xrefs": { "current": [ "VZ:869" ], "previous": "N/A" } } }, { "id": "GO:0040029", "name": "epigenetic regulation of gene expression", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-212165 \"Epigenetic regulation of gene expression\"", "Reactome:R-HSA-8986944 \"Transcriptional Regulation by MECP2\"" ], "previous": "N/A" } } }, { "id": "GO:0042059", "name": "negative regulation of epidermal growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-182971 \"EGFR downregulation\"" ], "previous": "N/A" } } }, { "id": "GO:0042167", "name": "heme catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-189483 \"Heme degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0042168", "name": "heme metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9707616 \"Heme signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0042203", "name": "toluene catabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:tol" ], "previous": "N/A" } } }, { "id": "GO:0042276", "name": "error-prone translesion synthesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-110312 \"Translesion synthesis by REV1\"", "Reactome:R-HSA-5655862 \"Translesion synthesis by POLK\"", "Reactome:R-HSA-5656121 \"Translesion synthesis by POLI\"" ], "previous": "N/A" } } }, { "id": "GO:0042304", "name": "regulation of fatty acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163680 \"AMPK inhibits chREBP transcriptional activation activity\"" ], "previous": "N/A" } } }, { "id": "GO:0042339", "name": "keratan sulfate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1638074 \"Keratan sulfate/keratin metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0042340", "name": "keratan sulfate catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2022857 \"Keratan sulfate degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0042350", "name": "GDP-L-fucose biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6787639 \"GDP-fucose biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0042359", "name": "vitamin D metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196791 \"Vitamin D (calciferol) metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0042360", "name": "vitamin E metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8877627 \"Vitamin E\"" ], "previous": "N/A" } } }, { "id": "GO:0042373", "name": "vitamin K metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6806664 \"Metabolism of vitamin K\"" ], "previous": "N/A" } } }, { "id": "GO:0042403", "name": "thyroid hormone metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-350864 \"Regulation of thyroid hormone activity\"" ], "previous": "N/A" } } }, { "id": "GO:0042407", "name": "cristae formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8949613 \"Cristae formation\"" ], "previous": "N/A" } } }, { "id": "GO:0042420", "name": "dopamine catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-379397 \"Enzymatic degradation of dopamine by COMT\"", "Reactome:R-HSA-379398 \"Enzymatic degradation of Dopamine by monoamine oxidase\"" ], "previous": "N/A" } } }, { "id": "GO:0042423", "name": "catecholamine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-209905 \"Catecholamine biosynthesis\"", "Wikipedia:Catecholamines" ], "previous": [ "Wikipedia:Catecholamines" ] } } }, { "id": "GO:0042426", "name": "choline catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6798163 \"Choline catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0042429", "name": "serotonin catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-380612 \"Metabolism of serotonin\"" ], "previous": "N/A" } } }, { "id": "GO:0042438", "name": "melanin biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5662702 \"Melanin biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0042590", "name": "antigen processing and presentation of exogenous peptide antigen via MHC class I", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1236975 \"Antigen processing-Cross presentation\"" ], "previous": "N/A" } } }, { "id": "GO:0042723", "name": "thiamine-containing compound metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196819 \"Vitamin B1 (thiamin) metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0042730", "name": "fibrinolysis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75205 \"Dissolution of Fibrin Clot\"", "Wikipedia:Fibrinolysis" ], "previous": [ "Wikipedia:Fibrinolysis" ] } } }, { "id": "GO:0042759", "name": "long-chain fatty acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9018677 \"Biosynthesis of DHA-derived SPMs\"", "Reactome:R-HSA-9018679 \"Biosynthesis of EPA-derived SPMs\"", "Reactome:R-HSA-9018683 \"Biosynthesis of DPA-derived SPMs\"", "Reactome:R-HSA-9026403 \"Biosynthesis of DPAn-3-derived 13-series resolvins\"", "Reactome:R-HSA-9027604 \"Biosynthesis of electrophilic -3 PUFA oxo-derivatives\"" ], "previous": "N/A" } } }, { "id": "GO:0042776", "name": "proton motive force-driven mitochondrial ATP synthesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163210 \"Formation of ATP by chemiosmotic coupling\"" ], "previous": "N/A" } } }, { "id": "GO:0042795", "name": "snRNA transcription by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6807505 \"RNA polymerase II transcribes snRNA genes\"" ], "previous": "N/A" } } }, { "id": "GO:0042816", "name": "vitamin B6 metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-964975 \"Vitamin B6 activation to pyridoxal phosphate\"" ], "previous": "N/A" } } }, { "id": "GO:0042981", "name": "regulation of apoptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-169911 \"Regulation of Apoptosis\"", "Reactome:R-HSA-5633008 \"TP53 Regulates Transcription of Cell Death Genes\"" ], "previous": "N/A" } } }, { "id": "GO:0043043", "name": "peptide biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9037628 \"Rhesus blood group biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0043065", "name": "positive regulation of apoptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193648 \"NRAGE signals death through JNK\"", "Reactome:R-HSA-205043 \"NRIF signals cell death from the nucleus\"" ], "previous": "N/A" } } }, { "id": "GO:0043066", "name": "negative regulation of apoptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193639 \"p75NTR signals via NF-kB\"", "Reactome:R-HSA-211728 \"Regulation of PAK-2p34 activity by PS-GAP/RHG10\"", "Reactome:R-HSA-211733 \"Regulation of activated PAK-2p34 by proteasome mediated degradation\"" ], "previous": "N/A" } } }, { "id": "GO:0043097", "name": "pyrimidine nucleoside salvage", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73614 \"Pyrimidine salvage\"" ], "previous": "N/A" } } }, { "id": "GO:0043101", "name": "purine-containing compound salvage", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-74217 \"Purine salvage\"" ], "previous": "N/A" } } }, { "id": "GO:0043123", "name": "positive regulation of canonical NF-kappaB signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-937039 \"IRAK1 recruits IKK complex\"" ], "previous": "N/A" } } }, { "id": "GO:0043161", "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75815 \"Ubiquitin-dependent degradation of Cyclin D\"" ], "previous": "N/A" } } }, { "id": "GO:0043173", "name": "nucleotide salvage", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8956321 \"Nucleotide salvage\"", "Wikipedia:Nucleotide_salvage" ], "previous": [ "Wikipedia:Nucleotide_salvage" ] } } }, { "id": "GO:0043248", "name": "proteasome assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9907900 \"Proteasome assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0043252", "name": "sodium-independent organic anion transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-879518 \"Transport of organic anions\"" ], "previous": "N/A" } } }, { "id": "GO:0043312", "name": "neutrophil degranulation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6798695 \"Neutrophil degranulation\"" ], "previous": "N/A" } } }, { "id": "GO:0043467", "name": "regulation of generation of precursor metabolites and energy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163685 \"Integration of energy metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0043488", "name": "regulation of mRNA stability", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-428359 \"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA\"", "Reactome:R-HSA-450531 \"Regulation of mRNA stability by proteins that bind AU-rich elements\"" ], "previous": "N/A" } } }, { "id": "GO:0043490", "name": "malate-aspartate shuttle", "changes": { "xrefs": { "current": [ "MetaCyc:MALATE-ASPARTATE-SHUTTLE-PWY", "Reactome:R-HSA-9856872 \"Malate-aspartate shuttle\"", "Wikipedia:Malate-aspartate_shuttle" ], "previous": [ "Wikipedia:Malate-aspartate_shuttle" ] } } }, { "id": "GO:0043491", "name": "phosphatidylinositol 3-kinase/protein kinase B signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-198203 \"PI3K/AKT activation\"", "Reactome:R-HSA-198323 \"AKT phosphorylates targets in the cytosol\"", "Reactome:R-HSA-198693 \"AKT phosphorylates targets in the nucleus\"" ], "previous": "N/A" } } }, { "id": "GO:0043647", "name": "inositol phosphate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483249 \"Inositol phosphate metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0043651", "name": "linoleic acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2046105 \"Linoleic acid (LA) metabolism\"", "Wikipedia:Linoleic_acid" ], "previous": [ "Wikipedia:Linoleic_acid" ] } } }, { "id": "GO:0043687", "name": "post-translational protein modification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-597592 \"Post-translational protein modification\"", "Wikipedia:Posttranslational_modification" ], "previous": [ "Wikipedia:Posttranslational_modification" ] } } }, { "id": "GO:0044003", "name": "symbiont-mediated perturbation of host process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9635644 \"Inhibition of membrane repair\"", "Reactome:R-HSA-9636667 \"Manipulation of host energy metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0044241", "name": "lipid digestion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-192456 \"Digestion of dietary lipid\"" ], "previous": "N/A" } } }, { "id": "GO:0044245", "name": "polysaccharide digestion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-189085 \"Digestion of dietary carbohydrate\"" ], "previous": "N/A" } } }, { "id": "GO:0044409", "name": "symbiont entry into host", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-173107 \"Binding and entry of HIV virion\"" ], "previous": "N/A" } } }, { "id": "GO:0044419", "name": "biological process involved in interspecies interaction between organisms", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9824443 \"Parasitic Infection Pathways\"" ], "previous": "N/A" } } }, { "id": "GO:0044528", "name": "regulation of mitochondrial mRNA stability", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9837092 \"FASTK family proteins regulate processing and stability of mitochondrial RNAs\"" ], "previous": "N/A" } } }, { "id": "GO:0044725", "name": "epigenetic programming in the zygotic pronuclei", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9821002 \"Chromatin modifications during the maternal to zygotic transition (MZT)\"", "Reactome:R-HSA-9821993 \"Replacement of protamines by nucleosomes in the male pronucleus\"" ], "previous": "N/A" } } }, { "id": "GO:0045003", "name": "double-strand break repair via synthesis-dependent strand annealing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5693554 \"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)\"" ], "previous": "N/A" } } }, { "id": "GO:0045007", "name": "depurination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73927 \"Depurination\"", "Wikipedia:Depurination" ], "previous": [ "Wikipedia:Depurination" ] } } }, { "id": "GO:0045008", "name": "depyrimidination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73928 \"Depyrimidination\"" ], "previous": "N/A" } } }, { "id": "GO:0045046", "name": "protein import into peroxisome membrane", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9603798 \"Class I peroxisomal membrane protein import\"" ], "previous": "N/A" } } }, { "id": "GO:0045048", "name": "protein insertion into ER membrane", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9609523 \"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0045087", "name": "innate immune response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168249 \"Innate Immune System\"", "Wikipedia:Innate_immune_system" ], "previous": [ "Wikipedia:Innate_immune_system" ] } } }, { "id": "GO:0045216", "name": "cell-cell junction organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-421270 \"Cell-cell junction organization\"" ], "previous": "N/A" } } }, { "id": "GO:0045329", "name": "carnitine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71262 \"Carnitine synthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0045332", "name": "phospholipid translocation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1660502 \"PIPs transport between early and late endosome membranes\"", "Reactome:R-HSA-1660508 \"PIPs transport between late endosome and Golgi membranes\"", "Reactome:R-HSA-1660510 \"PIPs transport between Golgi and plasma membranes\"", "Reactome:R-HSA-1660524 \"PIPs transport between plasma and early endosome membranes\"", "Reactome:R-HSA-1660537 \"PIPs transport between early endosome and Golgi membranes\"" ], "previous": "N/A" } } }, { "id": "GO:0045454", "name": "cell redox homeostasis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222541 \"Cell redox homeostasis\"", "Reactome:R-HSA-1222556 \"ROS and RNS production in phagocytes\"", "Wikipedia:Redox" ], "previous": [ "Wikipedia:Redox" ] } } }, { "id": "GO:0045540", "name": "regulation of cholesterol biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1655829 \"Regulation of cholesterol biosynthesis by SREBP (SREBF)\"" ], "previous": "N/A" } } }, { "id": "GO:0045589", "name": "regulation of regulatory T cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8877330 \"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)\"" ], "previous": "N/A" } } }, { "id": "GO:0045616", "name": "regulation of keratinocyte differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939242 \"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes\"" ], "previous": "N/A" } } }, { "id": "GO:0045637", "name": "regulation of myeloid cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939246 \"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells\"" ], "previous": "N/A" } } }, { "id": "GO:0045652", "name": "regulation of megakaryocyte differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8936459 \"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function\"" ], "previous": "N/A" } } }, { "id": "GO:0045740", "name": "positive regulation of DNA replication", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-69656 \"Cyclin A:Cdk2-associated events at S phase entry\"" ], "previous": "N/A" } } }, { "id": "GO:0045742", "name": "positive regulation of epidermal growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8849469 \"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1\"" ], "previous": "N/A" } } }, { "id": "GO:0045746", "name": "negative regulation of Notch signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9604323 \"Negative regulation of NOTCH4 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0045786", "name": "negative regulation of cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193670 \"p75NTR negatively regulates cell cycle via SC1\"" ], "previous": "N/A" } } }, { "id": "GO:0045787", "name": "positive regulation of cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8849470 \"PTK6 Regulates Cell Cycle\"" ], "previous": "N/A" } } }, { "id": "GO:0045814", "name": "negative regulation of gene expression, epigenetic", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-212300 \"PRC2 methylates histones and DNA\"", "Reactome:R-HSA-5250941 \"Negative epigenetic regulation of rRNA expression\"" ], "previous": "N/A" } } }, { "id": "GO:0045815", "name": "transcription initiation-coupled chromatin remodeling", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5250913 \"Positive epigenetic regulation of rRNA expression\"" ], "previous": "N/A" } } }, { "id": "GO:0045930", "name": "negative regulation of mitotic cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8854050 \"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis\"" ], "previous": "N/A" } } }, { "id": "GO:0045944", "name": "positive regulation of transcription by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2173796 \"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription\"", "Reactome:R-HSA-8866906 \"TFAP2 (AP-2) family regulates transcription of other transcription factors\"", "Reactome:R-HSA-8866907 \"Activation of the TFAP2 (AP-2) family of transcription factors\"" ], "previous": "N/A" } } }, { "id": "GO:0046134", "name": "pyrimidine nucleoside biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-500753 \"Pyrimidine biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0046135", "name": "pyrimidine nucleoside catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-73621 \"Pyrimidine catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0046146", "name": "tetrahydrobiopterin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1474151 \"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation\"" ], "previous": "N/A" } } }, { "id": "GO:0046209", "name": "nitric oxide metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-202131 \"Metabolism of nitric oxide" ], "previous": "N/A" } } }, { "id": "GO:0046219", "name": "indolalkylamine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-209931 \"Serotonin and melatonin biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0046222", "name": "aflatoxin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5423646 \"Aflatoxin activation and detoxification\"" ], "previous": "N/A" } } }, { "id": "GO:0046300", "name": "2,4-dichlorophenoxyacetic acid catabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:2\\,4-d" ], "previous": "N/A" } } }, { "id": "GO:0046370", "name": "fructose biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5652227 \"Fructose biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0046427", "name": "positive regulation of receptor signaling pathway via JAK-STAT", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8849474 \"PTK6 Activates STAT3\"" ], "previous": "N/A" } } }, { "id": "GO:0046457", "name": "prostanoid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2162123 \"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)\"", "Wikipedia:Prostanoid#Biosynthesis" ], "previous": [ "Wikipedia:Prostanoid#Biosynthesis" ] } } }, { "id": "GO:0046474", "name": "glycerophospholipid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483206 \"Glycerophospholipid biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0046475", "name": "glycerophospholipid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6814848 \"Glycerophospholipid catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0046479", "name": "glycosphingolipid catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9840310 \"Glycosphingolipid catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0046579", "name": "positive regulation of Ras protein signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9026519 \"Activated NTRK2 signals through RAS\"", "Reactome:R-HSA-9027284 \"Erythropoietin activates RAS\"", "Reactome:R-HSA-9034864 \"Activated NTRK3 signals through RAS\"" ], "previous": "N/A" } } }, { "id": "GO:0046655", "name": "folic acid metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-196757 \"Metabolism of folate and pterines\"" ], "previous": "N/A" } } }, { "id": "GO:0046676", "name": "negative regulation of insulin secretion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-400042 \"Adrenaline,noradrenaline inhibits insulin secretion\"" ], "previous": "N/A" } } }, { "id": "GO:0046677", "name": "response to antibiotic", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9639775 \"Antimicrobial action and antimicrobial resistance in Mtb\"" ], "previous": "N/A" } } }, { "id": "GO:0046718", "name": "symbiont entry into host cell", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168270 \"Fusion and Uncoating of the Influenza Virion\"", "Reactome:R-HSA-8876384 \"Listeria monocytogenes entry into host cells\"", "VZ:936 \"Virus entry\"" ], "previous": [ "VZ:936 \"Virus entry\"" ] } } }, { "id": "GO:0046949", "name": "fatty-acyl-CoA biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75105 \"Fatty acyl-CoA biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0046951", "name": "ketone body biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-77111 \"Synthesis of Ketone Bodies\"" ], "previous": "N/A" } } }, { "id": "GO:0046952", "name": "ketone body catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY66-368", "Reactome:R-HSA-77108 \"Utilization of Ketone Bodies\"" ], "previous": [ "MetaCyc:PWY66-368" ] } } }, { "id": "GO:0048009", "name": "insulin-like growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2404192 \"Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)\"" ], "previous": "N/A" } } }, { "id": "GO:0048010", "name": "vascular endothelial growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-194138 \"Signaling by VEGF\"" ], "previous": "N/A" } } }, { "id": "GO:0048011", "name": "neurotrophin TRK receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166520 \"Signaling by NTRKs\"", "Reactome:R-HSA-167021 \"PLC-gamma1 signalling\"", "Reactome:R-HSA-187042 \"TRKA activation by NGF\"", "Reactome:R-HSA-193704 \"p75 NTR receptor-mediated signalling\"" ], "previous": "N/A" } } }, { "id": "GO:0048012", "name": "hepatocyte growth factor receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8852405 \"Signaling by MST1\"" ], "previous": "N/A" } } }, { "id": "GO:0048013", "name": "ephrin receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2682334 \"EPH-Ephrin signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0048208", "name": "COPII vesicle coating", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-204005 \"COPII-mediated vesicle transport\"" ], "previous": "N/A" } } }, { "id": "GO:0048239", "name": "negative regulation of DNA recombination at telomere", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9670095 \"Inhibition of DNA recombination at telomere\"" ], "previous": "N/A" } } }, { "id": "GO:0048313", "name": "Golgi inheritance", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162658 \"Golgi Cisternae Pericentriolar Stack Reorganization\"" ], "previous": "N/A" } } }, { "id": "GO:0048320", "name": "axial mesoderm formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9796292 \"Formation of axial mesoderm\"" ], "previous": "N/A" } } }, { "id": "GO:0048341", "name": "paraxial mesoderm formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9793380 \"Formation of paraxial mesoderm\"" ], "previous": "N/A" } } }, { "id": "GO:0048370", "name": "lateral mesoderm formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9758920 \"Formation of lateral plate mesoderm\"" ], "previous": "N/A" } } }, { "id": "GO:0048391", "name": "intermediate mesoderm formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9761174 \"Formation of intermediate mesoderm\"" ], "previous": "N/A" } } }, { "id": "GO:0048609", "name": "multicellular organismal reproductive process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1474165 \"Reproduction\"" ], "previous": "N/A" } } }, { "id": "GO:0050427", "name": "3'-phosphoadenosine 5'-phosphosulfate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156584 \"Cytosolic sulfonation of small molecules\"" ], "previous": [ "MetaCyc:PWY-5340" ] } } }, { "id": "GO:0050428", "name": "3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5340" ], "previous": "N/A" } } }, { "id": "GO:0050434", "name": "positive regulation of viral transcription", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167246 \"Tat-mediated elongation of the HIV-1 transcript\"" ], "previous": "N/A" } } }, { "id": "GO:0050728", "name": "negative regulation of inflammatory response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9018678 \"Biosynthesis of specialized proresolving mediators (SPMs)\"" ], "previous": "N/A" } } }, { "id": "GO:0050770", "name": "regulation of axonogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193697 \"p75NTR regulates axonogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0050771", "name": "negative regulation of axonogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193634 \"Axonal growth inhibition (RHOA activation)\"" ], "previous": "N/A" } } }, { "id": "GO:0050772", "name": "positive regulation of axonogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-209563 \"Axonal growth stimulation\"" ], "previous": "N/A" } } }, { "id": "GO:0050776", "name": "regulation of immune response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-198933 \"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell\"" ], "previous": "N/A" } } }, { "id": "GO:0050796", "name": "regulation of insulin secretion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-422356 \"Regulation of insulin secretion\"" ], "previous": "N/A" } } }, { "id": "GO:0050852", "name": "T cell receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-202403 \"TCR signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0050855", "name": "regulation of B cell receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939245 \"RUNX1 regulates transcription of genes involved in BCR signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0050872", "name": "white fat cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381340 \"Transcriptional regulation of white adipocyte differentiation\"" ], "previous": "N/A" } } }, { "id": "GO:0050892", "name": "intestinal absorption", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963676 \"Intestinal absorption\"" ], "previous": "N/A" } } }, { "id": "GO:0050900", "name": "leukocyte migration", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-202733 \"Cell surface interactions at the vascular wall\"" ], "previous": "N/A" } } }, { "id": "GO:0050909", "name": "sensory perception of taste", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9717189 \"Sensory perception of taste\"", "Wikipedia:Taste" ], "previous": [ "Wikipedia:Taste" ] } } }, { "id": "GO:0051056", "name": "regulation of small GTPase mediated signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9012999 \"RHO GTPase cycle\"" ], "previous": "N/A" } } }, { "id": "GO:0051084", "name": "'de novo' post-translational protein folding", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-391251 \"Protein folding\"" ], "previous": "N/A" } } }, { "id": "GO:0051086", "name": "chaperone mediated protein folding independent of cofactor", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-390450 \"Folding of actin by CCT/TriC\"" ], "previous": "N/A" } } }, { "id": "GO:0051090", "name": "regulation of DNA-binding transcription factor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9708530 \"Regulation of BACH1 activity\"" ], "previous": "N/A" } } }, { "id": "GO:0051121", "name": "hepoxilin metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142696 \"Synthesis of Hepoxilins (HX) and Trioxilins (TrX)\"" ], "previous": "N/A" } } }, { "id": "GO:0051149", "name": "positive regulation of muscle cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-525793 \"Myogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0051306", "name": "mitotic sister chromatid separation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2467813 \"Separation of Sister Chromatids\"" ], "previous": "N/A" } } }, { "id": "GO:0051388", "name": "positive regulation of neurotrophin TRK receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9024909 \"BDNF activates NTRK2 (TRKB) signaling\"", "Reactome:R-HSA-9025046 \"NTF3 activates NTRK2 (TRKB) signaling\"", "Reactome:R-HSA-9026357 \"NTF4 activates NTRK2 (TRKB) signaling\"", "Reactome:R-HSA-9034013 \"NTF3 activates NTRK3 signaling\"", "Reactome:R-HSA-9034793 \"Activated NTRK3 signals through PLCG1\"" ], "previous": "N/A" } } }, { "id": "GO:0051403", "name": "stress-activated MAPK cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-450294 \"MAP kinase activation\"" ], "previous": "N/A" } } }, { "id": "GO:0051607", "name": "defense response to virus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8983711 \"OAS antiviral response\"" ], "previous": "N/A" } } }, { "id": "GO:0051701", "name": "biological process involved in interaction with host", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9635486 \"Infection with Mycobacterium tuberculosis\"", "Reactome:R-HSA-9658195 \"Leishmania infection\"" ], "previous": "N/A" } } }, { "id": "GO:0051711", "name": "negative regulation of killing of cells of another organism", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9662851 \"Anti-inflammatory response favouring Leishmania parasite infection\"" ], "previous": "N/A" } } }, { "id": "GO:0051716", "name": "cellular response to stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8953897 \"Cellular responses to stimuli\"" ], "previous": "N/A" } } }, { "id": "GO:0051726", "name": "regulation of cell cycle", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156711 \"Polo-like kinase mediated events\"", "Reactome:R-HSA-380972 \"Energy dependent regulation of mTOR by LKB1-AMPK\"" ], "previous": "N/A" } } }, { "id": "GO:0051896", "name": "regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6811558 \"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0051897", "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1257604 \"PIP3 activates AKT signaling\"", "Reactome:R-HSA-165158 \"Activation of AKT2\"", "Reactome:R-HSA-9027276 \"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)\"", "Reactome:R-HSA-9028335 \"Activated NTRK2 signals through PI3K\"", "Reactome:R-HSA-9603381 \"Activated NTRK3 signals through PI3K\"" ], "previous": "N/A" } } }, { "id": "GO:0051899", "name": "membrane depolarization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112308 \"Presynaptic depolarization and calcium channel opening\"" ], "previous": "N/A" } } }, { "id": "GO:0051936", "name": "gamma-aminobutyric acid reuptake", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-888593 \"Reuptake of GABA\"" ], "previous": "N/A" } } }, { "id": "GO:0052031", "name": "symbiont-mediated perturbation of host defense response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9637628 \"Modulation by Mtb of host immune system\"", "Reactome:R-HSA-9637690 \"Response of Mtb to phagocytosis\"" ], "previous": "N/A" } } }, { "id": "GO:0052150", "name": "symbiont-mediated perturbation of host apoptosis", "changes": { "xrefs": { "current": [ "VZ:1518 \"Apoptosis modulation\"" ], "previous": [ "VZ:1518 \"Apoptosis modulation\"", "VZ:1581 \"Apoptosis modulation\"" ] } } }, { "id": "GO:0052164", "name": "symbiont defense to host-produced reactive oxygen species", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222387 \"Tolerance of reactive oxygen produced by macrophages\"" ], "previous": "N/A" } } }, { "id": "GO:0052165", "name": "symbiont-mediated perturbation of host phytoalexin production", "changes": { "xrefs": { "current": [ "PMID:28805743" ], "previous": "N/A" } } }, { "id": "GO:0052170", "name": "symbiont-mediated suppression of host innate immune response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9637687 \"Suppression of phagosomal maturation\"" ], "previous": "N/A" } } }, { "id": "GO:0052572", "name": "response to host immune response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222499 \"Latent infection - Other responses of Mtb to phagocytosis\"" ], "previous": "N/A" } } }, { "id": "GO:0052776", "name": "chitin catabolic process to fructose 6-phosphate via glucosamine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6855" ], "previous": "N/A" } } }, { "id": "GO:0055085", "name": "transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-382556 \"ABC-family proteins mediated transport\"", "Reactome:R-HSA-425407 \"SLC-mediated transmembrane transport\"", "Reactome:R-HSA-5223345 \"Miscellaneous transport and binding events\"" ], "previous": "N/A" } } }, { "id": "GO:0055086", "name": "nucleobase-containing small molecule metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-15869 \"Metabolism of nucleotides\"", "Reactome:R-HSA-2393930 \"Phosphate bond hydrolysis by NUDT proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0060070", "name": "canonical Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-4641262 \"Disassembly of the destruction complex and recruitment of AXIN to the membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0060071", "name": "Wnt signaling pathway, planar cell polarity pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-4086400 \"PCP/CE pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0060236", "name": "regulation of mitotic spindle organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-380320 \"Recruitment of NuMA to mitotic centrosomes\"" ], "previous": "N/A" } } }, { "id": "GO:0060260", "name": "regulation of transcription initiation by RNA polymerase II", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-212436 \"Generic Transcription Pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0060271", "name": "cilium assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5617833 \"Cilium Assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0060326", "name": "cell chemotaxis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664424 \"Cell recruitment (pro-inflammatory response)\"" ], "previous": "N/A" } } }, { "id": "GO:0060333", "name": "type II interferon-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-877300 \"Interferon gamma signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0060334", "name": "regulation of type II interferon-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-877312 \"Regulation of IFNG signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0060337", "name": "type I interferon-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-909733 \"Interferon alpha/beta signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0060338", "name": "regulation of type I interferon-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-912694 \"Regulation of IFNA/IFNB signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0060397", "name": "growth hormone receptor signaling pathway via JAK-STAT", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-982772 \"Growth hormone receptor signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0060544", "name": "regulation of necroptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5675482 \"Regulation of necroptotic cell death\"" ], "previous": "N/A" } } }, { "id": "GO:0060676", "name": "ureteric bud formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9830674 \"Formation of the ureteric bud\"" ], "previous": "N/A" } } }, { "id": "GO:0060765", "name": "regulation of androgen receptor signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5625886 \"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3\"" ], "previous": "N/A" } } }, { "id": "GO:0060896", "name": "neural plate pattern specification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9834899 \"Specification of the neural plate border\"" ], "previous": "N/A" } } }, { "id": "GO:0060914", "name": "heart formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9733709 \"Cardiogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:0060964", "name": "regulation of miRNA-mediated gene silencing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5578749 \"Transcriptional regulation by small RNAs\"" ], "previous": "N/A" } } }, { "id": "GO:0061024", "name": "membrane organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-199991 \"Membrane Trafficking\"" ], "previous": "N/A" } } }, { "id": "GO:0061337", "name": "cardiac conduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5576891 \"Cardiac conduction\"" ], "previous": "N/A" } } }, { "id": "GO:0061621", "name": "canonical glycolysis", "changes": { "xrefs": { "current": [ "MetaCyc:ANAGLYCOLYSIS-PWY", "Reactome:R-HSA-70171 \"Glycolysis\"", "Wikipedia:Glycolysis" ], "previous": [ "MetaCyc:ANAGLYCOLYSIS-PWY", "Wikipedia:Glycolysis" ] } } }, { "id": "GO:0061624", "name": "fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-70350 \"Fructose catabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0061684", "name": "chaperone-mediated autophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9613829 \"Chaperone Mediated Autophagy\"", "Wikipedia:Chaperone-mediated_autophagy" ], "previous": [ "Wikipedia:Chaperone-mediated_autophagy" ] } } }, { "id": "GO:0061724", "name": "lipophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9613354 \"Lipophagy\"" ], "previous": "N/A" } } }, { "id": "GO:0061729", "name": "GDP-D-mannose biosynthetic process from fructose-6-phosphate", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5659" ], "previous": "N/A" } } }, { "id": "GO:0061738", "name": "late endosomal microautophagy", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9615710 \"Late endosomal microautophagy\"" ], "previous": "N/A" } } }, { "id": "GO:0062012", "name": "regulation of small molecule metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9861718 \"Regulation of pyruvate metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:0062197", "name": "cellular response to chemical stress", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9711123 \"Cellular response to chemical stress\"" ], "previous": "N/A" } } }, { "id": "GO:0070102", "name": "interleukin-6-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1059683 \"Interleukin-6 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0070106", "name": "interleukin-27-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9020956 \"Interleukin-27 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0070124", "name": "mitochondrial translational initiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5368286 \"Mitochondrial translation initiation\"" ], "previous": "N/A" } } }, { "id": "GO:0070125", "name": "mitochondrial translational elongation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5389840 \"Mitochondrial translation elongation\"" ], "previous": "N/A" } } }, { "id": "GO:0070126", "name": "mitochondrial translational termination", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5419276 \"Mitochondrial translation termination\"" ], "previous": "N/A" } } }, { "id": "GO:0070221", "name": "sulfide oxidation, using sulfide:quinone oxidoreductase", "changes": { "xrefs": { "current": [ "MetaCyc:P222-PWY", "Reactome:R-HSA-1614517 \"Sulfide oxidation to sulfate\"" ], "previous": [ "MetaCyc:P222-PWY" ] } } }, { "id": "GO:0070266", "name": "necroptotic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5213460 \"RIPK1-mediated regulated necrosis\"" ], "previous": "N/A" } } }, { "id": "GO:0070268", "name": "cornification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6809371 \"Formation of the cornified envelope\"" ], "previous": "N/A" } } }, { "id": "GO:0070269", "name": "pyroptotic inflammatory response", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5620971 \"Pyroptosis\"" ], "previous": "N/A" } } }, { "id": "GO:0070317", "name": "negative regulation of G0 to G1 transition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8953750 \"Transcriptional Regulation by E2F6\"" ], "previous": "N/A" } } }, { "id": "GO:0070371", "name": "ERK1 and ERK2 cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112409 \"RAF-independent MAPK1/3 activation\"" ], "previous": "N/A" } } }, { "id": "GO:0070498", "name": "interleukin-1-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9020702 \"Interleukin-1 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0070588", "name": "calcium ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3295583 \"TRP channels\"" ], "previous": "N/A" } } }, { "id": "GO:0070757", "name": "interleukin-35-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8984722 \"Interleukin-35 Signalling\"" ], "previous": "N/A" } } }, { "id": "GO:0070830", "name": "bicellular tight junction assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-420029 \"Tight junction interactions\"" ], "previous": "N/A" } } }, { "id": "GO:0070900", "name": "mitochondrial tRNA modification", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6787450 \"tRNA modification in the mitochondrion\"" ], "previous": "N/A" } } }, { "id": "GO:0070911", "name": "global genome nucleotide-excision repair", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5696399 \"Global Genome Nucleotide Excision Repair (GG-NER)\"" ], "previous": "N/A" } } }, { "id": "GO:0070987", "name": "error-free translesion synthesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-110320 \"Translesion Synthesis by POLH\"" ], "previous": "N/A" } } }, { "id": "GO:0071260", "name": "cellular response to mechanical stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9855142 \"Cellular responses to mechanical stimuli\"" ], "previous": "N/A" } } }, { "id": "GO:0071344", "name": "diphosphate metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71737 \"Pyrophosphate hydrolysis\"" ], "previous": "N/A" } } }, { "id": "GO:0071345", "name": "cellular response to cytokine stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9007892 \"Interleukin-38 signaling\"", "Reactome:R-HSA-9008059 \"Interleukin-37 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0071377", "name": "cellular response to glucagon stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-163359 \"Glucagon signaling in metabolic regulation\"" ], "previous": "N/A" } } }, { "id": "GO:0071383", "name": "cellular response to steroid hormone stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3371497 \"HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand\"" ], "previous": "N/A" } } }, { "id": "GO:0071456", "name": "cellular response to hypoxia", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1234174 \"Cellular response to hypoxia\"" ], "previous": "N/A" } } }, { "id": "GO:0071495", "name": "cellular response to endogenous stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9860931 \"Response of endothelial cells to shear stress\"" ], "previous": "N/A" } } }, { "id": "GO:0071514", "name": "genomic imprinting", "changes": { "xrefs": { "current": "N/A", "previous": [ "Wikipedia:Genomic_imprinting" ] } } }, { "id": "GO:0071550", "name": "death-inducing signaling complex assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5357786 \"TNFR1-induced proapoptotic signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0071577", "name": "zinc ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-435354 \"Zinc transporters\"" ], "previous": "N/A" } } }, { "id": "GO:0071805", "name": "potassium ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1296071 \"Potassium Channels\"" ], "previous": "N/A" } } }, { "id": "GO:0071827", "name": "plasma lipoprotein particle organization", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-174824 \"Plasma lipoprotein assembly, remodeling, and clearance\"" ], "previous": "N/A" } } }, { "id": "GO:0072179", "name": "nephric duct formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9830364 \"Formation of the nephric duct\"" ], "previous": "N/A" } } }, { "id": "GO:0072210", "name": "metanephric nephron development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9831926 \"Nephron development\"" ], "previous": "N/A" } } }, { "id": "GO:0072530", "name": "purine-containing compound transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2161517 \"Abacavir transmembrane transport\"" ], "previous": "N/A" } } }, { "id": "GO:0075001", "name": "adhesion of symbiont infection structure to host", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9664407 \"Parasite infection\"" ], "previous": "N/A" } } }, { "id": "GO:0075713", "name": "establishment of integrated proviral latency", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-162592 \"Integration of provirus\"", "VZ:980 \"Viral genome integration\"" ], "previous": [ "VZ:980 \"Viral genome integration\"" ] } } }, { "id": "GO:0075733", "name": "intracellular transport of virus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-168271 \"Transport of Ribonucleoproteins into the Host Nucleus\"", "Reactome:R-HSA-168274 \"Export of Viral Ribonucleoproteins from Nucleus\"", "Reactome:R-HSA-174490 \"Membrane binding and targetting of GAG proteins\"" ], "previous": "N/A" } } }, { "id": "GO:0090009", "name": "primitive streak formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9754189 \"Germ layer formation at gastrulation\"" ], "previous": "N/A" } } }, { "id": "GO:0090017", "name": "anterior neural plate formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9823739 \"Formation of the anterior neural plate\"" ], "previous": "N/A" } } }, { "id": "GO:0090018", "name": "posterior neural plate formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9832991 \"Formation of the posterior neural plate\"" ], "previous": "N/A" } } }, { "id": "GO:0090090", "name": "negative regulation of canonical Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3772470 \"Negative regulation of TCF-dependent signaling by WNT ligand antagonists\"", "Reactome:R-HSA-4641258 \"Degradation of DVL\"" ], "previous": "N/A" } } }, { "id": "GO:0090263", "name": "positive regulation of canonical Wnt signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-4641257 \"Degradation of AXIN\"" ], "previous": "N/A" } } }, { "id": "GO:0090335", "name": "regulation of brown fat cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9843743 \"Transcriptional regulation of brown and beige adipocyte differentiation\"" ], "previous": "N/A" } } }, { "id": "GO:0090398", "name": "cellular senescence", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2559583 \"Cellular Senescence\"" ], "previous": "N/A" } } }, { "id": "GO:0090638", "name": "phosphatidylcholine biosynthesis from phosphatidylethanolamine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6825" ], "previous": "N/A" } } }, { "id": "GO:0090640", "name": "phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7470" ], "previous": "N/A" } } }, { "id": "GO:0090646", "name": "mitochondrial tRNA processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6785470 \"tRNA processing in the mitochondrion\"" ], "previous": "N/A" } } }, { "id": "GO:0097055", "name": "agmatine biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-351143 \"Agmatine biosynthesis\"" ], "previous": "N/A" } } }, { "id": "GO:0097190", "name": "apoptotic signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193681 \"Ceramide signalling\"", "Reactome:R-HSA-204998 \"Cell death signalling via NRAGE, NRIF and NADE\"", "Reactome:R-HSA-75157 \"FasL/ CD95L signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0097191", "name": "extrinsic apoptotic signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5357769 \"Caspase activation via extrinsic apoptotic signalling pathway\"" ], "previous": "N/A" } } }, { "id": "GO:0097192", "name": "extrinsic apoptotic signaling pathway in absence of ligand", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-418889 \"Caspase activation via Dependence Receptors in the absence of ligand\"" ], "previous": "N/A" } } }, { "id": "GO:0097193", "name": "intrinsic apoptotic signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-109606 \"Intrinsic Pathway for Apoptosis\"" ], "previous": "N/A" } } }, { "id": "GO:0097194", "name": "execution phase of apoptosis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-75153 \"Apoptotic execution phase\"" ], "previous": "N/A" } } }, { "id": "GO:0097267", "name": "omega-hydroxylase P450 pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142816 \"Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)\"" ], "previous": "N/A" } } }, { "id": "GO:0097300", "name": "programmed necrotic cell death", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5218859 \"Regulated Necrosis\"" ], "previous": "N/A" } } }, { "id": "GO:0097400", "name": "interleukin-17-mediated signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-448424 \"Interleukin-17 signaling\"" ], "previous": "N/A" } } }, { "id": "GO:0097700", "name": "vascular endothelial cell response to laminar fluid shear stress", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9856530 \"High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells\"" ], "previous": "N/A" } } }, { "id": "GO:0097706", "name": "vascular endothelial cell response to oscillatory fluid shear stress", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9860927 \"Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells\"" ], "previous": "N/A" } } }, { "id": "GO:0097711", "name": "ciliary basal body-plasma membrane docking", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5620912 \"Anchoring of the basal body to the plasma membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0098780", "name": "response to mitochondrial depolarisation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9840373 \"Cellular response to mitochondrial stress\"" ], "previous": "N/A" } } }, { "id": "GO:0098856", "name": "intestinal lipid absorption", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8963678 \"Intestinal lipid absorption\"" ], "previous": "N/A" } } }, { "id": "GO:0106001", "name": "intestinal hexose absorption", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8981373 \"Intestinal hexose absorption\"" ], "previous": "N/A" } } }, { "id": "GO:0120116", "name": "glucagon processing", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-381771 \"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)\"" ], "previous": "N/A" } } }, { "id": "GO:0141005", "name": "transposable element silencing by heterochromatin formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9842860 \"Regulation of endogenous retroelements\"" ], "previous": "N/A" } } }, { "id": "GO:0141006", "name": "transposable element silencing by piRNA-mediated heterochromatin formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9845323 \"Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)\"" ], "previous": "N/A" } } }, { "id": "GO:0141082", "name": "symbiont-mediated detoxification of host-generated reactive oxygen species", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222538 \"Tolerance by Mtb to nitric oxide produced by macrophages\"" ], "previous": "N/A" } } }, { "id": "GO:0141167", "name": "chromosomal 5-methylcytosine DNA demethylation, oxidation pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5221030 \"TET1,2,3 and TDG demethylate DNA\"" ], "previous": "N/A" } } }, { "id": "GO:0160021", "name": "maternal-to-zygotic transition of gene expression", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9816359 \"Maternal to zygotic transition (MZT)\"" ], "previous": "N/A" } } }, { "id": "GO:1900034", "name": "regulation of cellular response to heat", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3371453 \"Regulation of HSF1-mediated heat shock response\"", "Reactome:R-HSA-3371571 \"HSF1-dependent transactivation\"" ], "previous": "N/A" } } }, { "id": "GO:1901030", "name": "positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-111452 \"Activation and oligomerization of BAK protein\"", "Reactome:R-HSA-114294 \"Activation, translocation and oligomerization of BAX\"" ], "previous": "N/A" } } }, { "id": "GO:1901158", "name": "neomycin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7016" ], "previous": "N/A" } } }, { "id": "GO:1901290", "name": "succinyl-CoA biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9853506 \"OGDH complex synthesizes succinyl-CoA from 2-OG\"" ], "previous": "N/A" } } }, { "id": "GO:1901381", "name": "positive regulation of potassium ion transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1296041 \"Activation of G protein gated Potassium channels\"", "Reactome:R-HSA-1296052 \"Ca2+ activated K+ channels\"" ], "previous": "N/A" } } }, { "id": "GO:1901687", "name": "glutathione derivative biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156590 \"Glutathione conjugation\"" ], "previous": "N/A" } } }, { "id": "GO:1901774", "name": "lincomycin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6955" ], "previous": "N/A" } } }, { "id": "GO:1901780", "name": "pentalenolactone biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6915" ], "previous": "N/A" } } }, { "id": "GO:1901782", "name": "p-cumate catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5273" ], "previous": "N/A" } } }, { "id": "GO:1901796", "name": "regulation of signal transduction by p53 class mediator", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5633007 \"Regulation of TP53 Activity\"" ], "previous": "N/A" } } }, { "id": "GO:1901802", "name": "1,5-anhydro-D-fructose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6992" ], "previous": "N/A" } } }, { "id": "GO:1901812", "name": "beta-carotene biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5943" ], "previous": "N/A" } } }, { "id": "GO:1901815", "name": "astaxanthin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5288" ], "previous": "N/A" } } }, { "id": "GO:1901824", "name": "alpha-carotene biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5946" ], "previous": "N/A" } } }, { "id": "GO:1901827", "name": "zeaxanthin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5944" ], "previous": "N/A" } } }, { "id": "GO:1901830", "name": "zeaxanthin bis(beta-D-glucoside) biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6288" ], "previous": "N/A" } } }, { "id": "GO:1901833", "name": "neoxanthin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6809" ], "previous": "N/A" } } }, { "id": "GO:1901990", "name": "regulation of mitotic cell cycle phase transition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-174113 \"SCF-beta-TrCP mediated degradation of Emi1\"", "Reactome:R-HSA-176412 \"Phosphorylation of the APC/C\"" ], "previous": "N/A" } } }, { "id": "GO:1902036", "name": "regulation of hematopoietic stem cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8939236 \"RUNX1 regulates transcription of genes involved in differentiation of HSCs\"" ], "previous": "N/A" } } }, { "id": "GO:1902041", "name": "regulation of extrinsic apoptotic signaling pathway via death domain receptors", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3371378 \"Regulation by c-FLIP\"" ], "previous": "N/A" } } }, { "id": "GO:1902600", "name": "proton transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-167826 \"The fatty acid cycling model\"" ], "previous": "N/A" } } }, { "id": "GO:1902749", "name": "regulation of cell cycle G2/M phase transition", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8852276 \"The role of GTSE1 in G2/M progression after G2 checkpoint\"" ], "previous": "N/A" } } }, { "id": "GO:1903604", "name": "cytochrome metabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211958 \"Miscellaneous substrates\"" ], "previous": "N/A" } } }, { "id": "GO:1903749", "name": "positive regulation of establishment of protein localization to mitochondrion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-114452 \"Activation of BH3-only proteins\"", "Reactome:R-HSA-75108 \"Activation, myristolyation of BID and translocation to mitochondria\"" ], "previous": "N/A" } } }, { "id": "GO:1903779", "name": "regulation of cardiac conduction", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5578768 \"Physiological factors\"", "Reactome:R-HSA-5578775 \"Ion homeostasis\"" ], "previous": "N/A" } } }, { "id": "GO:1904177", "name": "regulation of adipose tissue development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9843745 \"Adipogenesis\"" ], "previous": "N/A" } } }, { "id": "GO:1904333", "name": "positive regulation of error-prone translesion synthesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-110314 \"Recognition of DNA damage by PCNA-containing replication complex\"" ], "previous": "N/A" } } }, { "id": "GO:1904380", "name": "endoplasmic reticulum mannose trimming", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-901032 \"ER Quality Control Compartment (ERQC)\"" ], "previous": "N/A" } } }, { "id": "GO:1904381", "name": "Golgi apparatus mannose trimming", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-964827 \"Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2\"" ], "previous": "N/A" } } }, { "id": "GO:1904538", "name": "regulation of glycolytic process through fructose-6-phosphate", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9634600 \"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism\"" ], "previous": "N/A" } } }, { "id": "GO:1904837", "name": "beta-catenin-TCF complex assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-201722 \"Formation of the beta-catenin:TCF transactivating complex\"" ], "previous": "N/A" } } }, { "id": "GO:1904894", "name": "positive regulation of receptor signaling pathway via STAT", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9027283 \"Erythropoietin activates STAT5\"" ], "previous": "N/A" } } }, { "id": "GO:1905784", "name": "regulation of anaphase-promoting complex-dependent catabolic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-176408 \"Regulation of APC/C activators between G1/S and early anaphase\"" ], "previous": "N/A" } } }, { "id": "GO:1990000", "name": "amyloid fibril formation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-977225 \"Amyloid fiber formation\"" ], "previous": "N/A" } } }, { "id": "GO:1990845", "name": "adaptive thermogenesis", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-166187 \"Mitochondrial Uncoupling\"" ], "previous": "N/A" } } }, { "id": "GO:2000047", "name": "regulation of cell-cell adhesion mediated by cadherin", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9764260 \"Regulation of Expression and Function of Type II Classical Cadherins\"" ], "previous": "N/A" } } }, { "id": "GO:2000074", "name": "regulation of type B pancreatic cell development", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-211163 \"AKT-mediated inactivation of FOXO1A\"" ], "previous": "N/A" } } }, { "id": "GO:2000145", "name": "regulation of cell motility", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6785631 \"ERBB2 Regulates Cell Motility\"" ], "previous": "N/A" } } }, { "id": "GO:2000304", "name": "positive regulation of ceramide biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5626978 \"TNFR1-mediated ceramide production\"" ], "previous": "N/A" } } }, { "id": "GO:2000310", "name": "regulation of NMDA receptor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-438066 \"Unblocking of NMDA receptors, glutamate binding and activation\"" ], "previous": "N/A" } } }, { "id": "GO:2000810", "name": "regulation of bicellular tight junction assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-8935964 \"RUNX1 regulates expression of components of tight junctions\"" ], "previous": "N/A" } } }, { "id": "GO:2001241", "name": "positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9603505 \"NTRK3 as a dependence receptor\"" ], "previous": "N/A" } } }, { "id": "GO:2001244", "name": "positive regulation of intrinsic apoptotic signaling pathway", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-111453 \"BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members\"" ], "previous": "N/A" } } }, { "id": "GO:2001301", "name": "lipoxin biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2142700 \"Biosynthesis of Lipoxins (LX)\"" ], "previous": "N/A" } } }, { "id": "GO:2001312", "name": "lysobisphosphatidic acid biosynthetic process", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1483171 \"Synthesis of BMP\"" ], "previous": "N/A" } } } ], "molecular_function": [ { "id": "GO:0004077", "name": "biotin--[biotin carboxyl-carrier protein] ligase activity", "changes": { "xrefs": { "current": [ "EC:6.3.4.15", "MetaCyc:BIOTINLIG-RXN", "RHEA:11756" ], "previous": [ "EC:6.3.4.15", "MetaCyc:BIOTINLIG-RXN", "Reactome:R-HSA-2993447 \"HLCS biotinylates 6x(PCCA:PCCB)\"", "Reactome:R-HSA-2993799 \"HLCS biotinylates 6xMCCC1:6xMCCC2\"", "Reactome:R-HSA-2993802 \"HLCS biotinylates PC:Mn2+\"", "Reactome:R-HSA-2993814 \"HLCS biotinylates ACACA:Mn2+\"", "Reactome:R-HSA-3323184 \"Defective HLCS does not biotinylate ACACA:Mn2+\"", "Reactome:R-HSA-4167511 \"HLCS biotinylates ACACB\"", "Reactome:R-HSA-9035987 \"Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2\"", "Reactome:R-HSA-9035988 \"Defective HLCS does not biotinylate PC:Mn2+\"", "Reactome:R-HSA-9035990 \"Defective HLCS does not biotinylate 6x(PCCA:PCCB)\"", "RHEA:11756" ] } } }, { "id": "GO:0004177", "name": "aminopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.11.-", "https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE", "MetaCyc:RXN0-5052", "Reactome:R-HSA-1236954 \"Trimming of peptides by IRAP in endocytic vesicles\"", "Reactome:R-HSA-2534096 \"METAP1/2 demethylates GNAT1\"", "Reactome:R-HSA-983162 \"Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases\"" ], "previous": [ "EC:3.4.11.-", "MetaCyc:RXN0-5052", "Reactome:R-HSA-1236954 \"Trimming of peptides by IRAP in endocytic vesicles\"", "Reactome:R-HSA-2534096 \"METAP1/2 demethylates GNAT1\"", "Reactome:R-HSA-983162 \"Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases\"" ] } } }, { "id": "GO:0004197", "name": "cysteine-type endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.22.-", "Reactome:R-HSA-114252 \"Cleavage of Procaspase-3 by the apoptosome\"", "Reactome:R-HSA-114259 \"Cleavage of Procaspase9 to caspase9\"", "Reactome:R-HSA-114261 \"Cleavage of Procaspase-7 by the apoptosome\"", "Reactome:R-HSA-1236948 \"Antigen processing by cathepsin S in endosoytic vesicle\"", "Reactome:R-HSA-139898 \"Caspase-8 activates BID by cleavage\"", "Reactome:R-HSA-139952 \"Caspase-8 processing in the DISC\"", "Reactome:R-HSA-1678920 \"TLR processing at low pH\"", "Reactome:R-HSA-1678981 \"TLR9 processing at neutral pH\"", "Reactome:R-HSA-201595 \"Caspase-mediated cleavage of plakophilin-1\"", "Reactome:R-HSA-201603 \"Caspase-mediated cleavage of PKC theta\"", "Reactome:R-HSA-201608 \"Caspase-mediated cleavage of alpha adducin\"", "Reactome:R-HSA-201611 \"Caspase-mediated cleavage of Rock-1\"", "Reactome:R-HSA-201622 \"Caspase-mediated cleavage of gelsolin\"", "Reactome:R-HSA-201628 \"Caspase-mediated cleavage of vimentin at DSVD (85)\"", "Reactome:R-HSA-201629 \"Caspase-mediated cleavage of Tau\"", "Reactome:R-HSA-201630 \"Caspase-mediated cleavage of Acinus\"", "Reactome:R-HSA-201631 \"Caspase-mediated cleavage of Desmoglein 3\"", "Reactome:R-HSA-201634 \"Caspase-mediated cleavage of FADK 1\"", "Reactome:R-HSA-201636 \"Caspase-mediated cleavage of Desmoplakin\"", "Reactome:R-HSA-201637 \"Caspase-mediated cleavage of plectin-1\"", "Reactome:R-HSA-201639 \"Caspase-mediated cleavage of GAS2\"", "Reactome:R-HSA-201640 \"Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha\"", "Reactome:R-HSA-2028692 \"Cleavage of p-STK4 (p-MST1) by caspase 3\"", "Reactome:R-HSA-2028697 \"Cleavage of p-STK3 (p-MST2) by caspase 3\"", "Reactome:R-HSA-202917 \"Caspase-mediated cleavage of Desmoglein 1\"", "Reactome:R-HSA-202939 \"Caspase-mediated cleavage of E-Cadherin\"", "Reactome:R-HSA-202947 \"Caspase mediated cleavage of APC\"", "Reactome:R-HSA-202960 \"Caspase mediated cleavage of C-IAP1\"", "Reactome:R-HSA-202966 \"Caspase mediated cleavage of HIP-55\"", "Reactome:R-HSA-202967 \"Caspase mediated cleavage of alpha-II-Fodrin\"", "Reactome:R-HSA-202969 \"Caspase mediated cleavage of beta-catenin\"", "Reactome:R-HSA-211186 \"Cleavage of DFF45 (224) by caspase-3\"", "Reactome:R-HSA-211190 \"Caspase 3-mediated cleavage of DFF45 (117)\"", "Reactome:R-HSA-211651 \"Cleavage of PAK-2 at 212\"", "Reactome:R-HSA-212552 \"Caspase 3-mediated cleavage of PKC delta\"", "Reactome:R-HSA-2130336 \"Initial proteolyis of Ii by aspartic proteases to lip22\"", "Reactome:R-HSA-2130349 \"Generation of CLIP from lip10\"", "Reactome:R-HSA-2130504 \"Cleavage of lip22 to lip10\"", "Reactome:R-HSA-2130706 \"MHC class II antigen processing\"", "Reactome:R-HSA-2562564 \"Caspase-8 processing within TLR4 complex\"", "Reactome:R-HSA-264865 \"Caspase-mediated cleavage of Lamin A\"", "Reactome:R-HSA-264871 \"Caspase-mediated cleavage of Lamin B1\"", "Reactome:R-HSA-3465448 \"Caspase-8 and FLIP(L) processing at DISC\"", "Reactome:R-HSA-350158 \"LGMN degrades GC\"", "Reactome:R-HSA-350318 \"Caspase-mediated cleavage of vimentin at TNLD (429)\"", "Reactome:R-HSA-350319 \"Caspase mediated cleavage of vimentin at IDVD (259)\"", "Reactome:R-HSA-350651 \"Caspase-mediated cleavage of MASK\"", "Reactome:R-HSA-351849 \"Caspase-mediated cleavage of Etk\"", "Reactome:R-HSA-351871 \"Caspase-mediated cleavage of Z0-2\"", "Reactome:R-HSA-351876 \"Caspase-mediated cleavage of occludin\"", "Reactome:R-HSA-351877 \"Caspase-mediated cleavage of Desmoglein 2\"", "Reactome:R-HSA-351894 \"Caspase mediated cleavage of BAP31\"", "Reactome:R-HSA-351901 \"Caspase-mediated cleavage of MST3\"", "Reactome:R-HSA-351913 \"Caspase-mediated cleavage of TJP1\"", "Reactome:R-HSA-351936 \"Caspase-mediated cleavage of claspin\"", "Reactome:R-HSA-352268 \"Cleavage of Satb1\"", "Reactome:R-HSA-418845 \"Activation of caspase-3\"", "Reactome:R-HSA-418846 \"Caspase cleavage of UNC5A\"", "Reactome:R-HSA-418852 \"Caspase cleavage of UNC5B\"", "Reactome:R-HSA-448703 \"Interleukin-1 family precursors are cleaved by caspase-1\"", "Reactome:R-HSA-5357828 \"RIPK1 is cleaved by CASP8\"", "Reactome:R-HSA-5634228 \"TRAF1 is cleaved by caspases\"", "Reactome:R-HSA-5660663 \"Caspase-8 cleaves IL1B precursor\"", "Reactome:R-HSA-5681987 \"LC3 is cleaved by ATG4\"", "Reactome:R-HSA-5682377 \"LC3 de-lipidation by ATG4\"", "Reactome:R-HSA-6814387 \"CASP14 cleaves filaggrin\"", "Reactome:R-HSA-9012556 \"IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37\"", "Reactome:R-HSA-9013895 \"Caspase-8 processing within TLR3 complex\"", "Reactome:R-HSA-933532 \"Processing of caspases\"", "Reactome:R-HSA-9603534 \"Unknown caspase cleaves NTRK3\"", "Reactome:R-HSA-9647632 \"CASP3 cleaves GSDME\"", "Reactome:R-HSA-9647680 \"CASP1 cleaves GSDMD\"", "Reactome:R-HSA-9647999 \"RCE1 cleaves S-Farn proRAS proteins\"", "Reactome:R-HSA-9684273 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9684309 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9684321 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9684336 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9684340 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9684351 \"pp1a cleaves itself\"", "Reactome:R-HSA-9684352 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9686088 \"CASP3 cleaves GSDMD\"", "Reactome:R-HSA-9686930 \"RIPK3 is cleaved by CASP8\"", "Reactome:R-HSA-9693929 \"RIPK1 variant is not cleaved by CASP8\"", "Reactome:R-HSA-9694338 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9694377 \"pp1a cleaves itself\"", "Reactome:R-HSA-9694441 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9694551 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9694601 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9694625 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9694732 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9697750 \"RIPK1 is cleaved by CASP8:FLIP(L)\"", "Reactome:R-HSA-9710101 \"CASP4, CASP5 cleave GSDMD\"", "Reactome:R-HSA-9729704 \"SARS-CoV-2 3CLpro dimer cleaves TAB1\"", "Reactome:R-HSA-9729730 \"SARS-CoV-2 nsp3 cleaves IRF3\"", "Reactome:R-HSA-9729741 \"SARS-CoV-2 3CLpro dimer cleaves NLRP12\"" ], "previous": [ "EC:3.4.22.-", "Reactome:R-HSA-114252 \"Cleavage of Procaspase-3 by the apoptosome\"", "Reactome:R-HSA-114259 \"Cleavage of Procaspase9 to caspase9\"", "Reactome:R-HSA-114261 \"Cleavage of Procaspase-7 by the apoptosome\"", "Reactome:R-HSA-1236948 \"Antigen processing by cathepsin S in endosoytic vesicle\"", "Reactome:R-HSA-139898 \"Caspase-8 activates BID by cleavage\"", "Reactome:R-HSA-139952 \"Caspase-8 processing in the DISC\"", "Reactome:R-HSA-1678920 \"TLR processing at low pH\"", "Reactome:R-HSA-1678981 \"TLR9 processing at neutral pH\"", "Reactome:R-HSA-201595 \"Caspase-mediated cleavage of plakophilin-1\"", "Reactome:R-HSA-201603 \"Caspase-mediated cleavage of PKC theta\"", "Reactome:R-HSA-201608 \"Caspase-mediated cleavage of alpha adducin\"", "Reactome:R-HSA-201611 \"Caspase-mediated cleavage of Rock-1\"", "Reactome:R-HSA-201622 \"Caspase-mediated cleavage of gelsolin\"", "Reactome:R-HSA-201628 \"Caspase-mediated cleavage of vimentin at DSVD (85)\"", "Reactome:R-HSA-201629 \"Caspase-mediated cleavage of Tau\"", "Reactome:R-HSA-201630 \"Caspase-mediated cleavage of Acinus\"", "Reactome:R-HSA-201631 \"Caspase-mediated cleavage of Desmoglein 3\"", "Reactome:R-HSA-201634 \"Caspase-mediated cleavage of FADK 1\"", "Reactome:R-HSA-201636 \"Caspase-mediated cleavage of Desmoplakin\"", "Reactome:R-HSA-201637 \"Caspase-mediated cleavage of plectin-1\"", "Reactome:R-HSA-201639 \"Caspase-mediated cleavage of GAS2\"", "Reactome:R-HSA-201640 \"Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha\"", "Reactome:R-HSA-2028692 \"Cleavage of p-STK4 (p-MST1) by caspase 3\"", "Reactome:R-HSA-2028697 \"Cleavage of p-STK3 (p-MST2) by caspase 3\"", "Reactome:R-HSA-202917 \"Caspase-mediated cleavage of Desmoglein 1\"", "Reactome:R-HSA-202939 \"Caspase-mediated cleavage of E-Cadherin\"", "Reactome:R-HSA-202947 \"Caspase mediated cleavage of APC\"", "Reactome:R-HSA-202960 \"Caspase mediated cleavage of C-IAP1\"", "Reactome:R-HSA-202966 \"Caspase mediated cleavage of HIP-55\"", "Reactome:R-HSA-202967 \"Caspase mediated cleavage of alpha-II-Fodrin\"", "Reactome:R-HSA-202969 \"Caspase mediated cleavage of beta-catenin\"", "Reactome:R-HSA-211186 \"Cleavage of DFF45 (224) by caspase-3\"", "Reactome:R-HSA-211190 \"Caspase 3-mediated cleavage of DFF45 (117)\"", "Reactome:R-HSA-211651 \"Cleavage of PAK-2 at 212\"", "Reactome:R-HSA-212552 \"Caspase 3-mediated cleavage of PKC delta\"", "Reactome:R-HSA-2130336 \"Initial proteolyis of Ii by aspartic proteases to lip22\"", "Reactome:R-HSA-2130349 \"Generation of CLIP from lip10\"", "Reactome:R-HSA-2130504 \"Cleavage of lip22 to lip10\"", "Reactome:R-HSA-2130706 \"MHC class II antigen processing\"", "Reactome:R-HSA-2562564 \"Caspase-8 processing within TLR4 complex\"", "Reactome:R-HSA-264865 \"Caspase-mediated cleavage of Lamin A\"", "Reactome:R-HSA-264871 \"Caspase-mediated cleavage of Lamin B1\"", "Reactome:R-HSA-3465448 \"Caspase-8 and FLIP(L) processing at DISC\"", "Reactome:R-HSA-350158 \"LGMN degrades GC\"", "Reactome:R-HSA-350318 \"Caspase-mediated cleavage of vimentin at TNLD (429)\"", "Reactome:R-HSA-350319 \"Caspase mediated cleavage of vimentin at IDVD (259)\"", "Reactome:R-HSA-350651 \"Caspase-mediated cleavage of MASK\"", "Reactome:R-HSA-351849 \"Caspase-mediated cleavage of Etk\"", "Reactome:R-HSA-351871 \"Caspase-mediated cleavage of Z0-2\"", "Reactome:R-HSA-351876 \"Caspase-mediated cleavage of occludin\"", "Reactome:R-HSA-351877 \"Caspase-mediated cleavage of Desmoglein 2\"", "Reactome:R-HSA-351894 \"Caspase mediated cleavage of BAP31\"", "Reactome:R-HSA-351901 \"Caspase-mediated cleavage of MST3\"", "Reactome:R-HSA-351913 \"Caspase-mediated cleavage of TJP1\"", "Reactome:R-HSA-351936 \"Caspase-mediated cleavage of claspin\"", "Reactome:R-HSA-352268 \"Cleavage of Satb1\"", "Reactome:R-HSA-418845 \"Activation of caspase-3\"", "Reactome:R-HSA-418846 \"Caspase cleavage of UNC5A\"", "Reactome:R-HSA-418852 \"Caspase cleavage of UNC5B\"", "Reactome:R-HSA-448703 \"Interleukin-1 family precursors are cleaved by caspase-1\"", "Reactome:R-HSA-5357828 \"RIPK1 is cleaved by CASP8\"", "Reactome:R-HSA-5634228 \"TRAF1 is cleaved by caspases\"", "Reactome:R-HSA-5660663 \"Caspase-8 cleaves IL1B precursor\"", "Reactome:R-HSA-5681987 \"LC3 is cleaved by ATG4\"", "Reactome:R-HSA-5682377 \"LC3 de-lipidation by ATG4\"", "Reactome:R-HSA-6800797 \"The PIDDosome activates CASP2\"", "Reactome:R-HSA-6814387 \"CASP14 cleaves filaggrin\"", "Reactome:R-HSA-9012556 \"IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37\"", "Reactome:R-HSA-9013895 \"Caspase-8 processing within TLR3 complex\"", "Reactome:R-HSA-933532 \"Processing of caspases\"", "Reactome:R-HSA-9603534 \"Unknown caspase cleaves NTRK3\"", "Reactome:R-HSA-9647632 \"CASP3 cleaves GSDME\"", "Reactome:R-HSA-9647680 \"CASP1 cleaves GSDMD\"", "Reactome:R-HSA-9647999 \"RCE1 cleaves S-Farn proRAS proteins\"", "Reactome:R-HSA-9684273 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9684309 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9684321 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9684336 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9684340 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9684351 \"pp1a cleaves itself\"", "Reactome:R-HSA-9684352 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9686088 \"CASP3 cleaves GSDMD\"", "Reactome:R-HSA-9686930 \"RIPK3 is cleaved by CASP8\"", "Reactome:R-HSA-9693929 \"RIPK1 variant is not cleaved by CASP8\"", "Reactome:R-HSA-9694338 \"nsp1-4 cleaves itself\"", "Reactome:R-HSA-9694377 \"pp1a cleaves itself\"", "Reactome:R-HSA-9694441 \"3CLp cleaves pp1a\"", "Reactome:R-HSA-9694551 \"3CLp cleaves nsp6-11\"", "Reactome:R-HSA-9694601 \"nsp3-4 cleaves itself\"", "Reactome:R-HSA-9694625 \"nsp3 cleaves nsp1-4\"", "Reactome:R-HSA-9694732 \"3CLp cleaves pp1ab\"", "Reactome:R-HSA-9697750 \"RIPK1 is cleaved by CASP8:FLIP(L)\"", "Reactome:R-HSA-9710101 \"CASP4, CASP5 cleave GSDMD\"", "Reactome:R-HSA-9729704 \"SARS-CoV-2 3CLpro dimer cleaves TAB1\"", "Reactome:R-HSA-9729730 \"SARS-CoV-2 nsp3 cleaves IRF3\"", "Reactome:R-HSA-9729741 \"SARS-CoV-2 3CLpro dimer cleaves NLRP12\"" ] } } }, { "id": "GO:0004619", "name": "phosphoglycerate mutase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R01516", "Reactome:R-HSA-71445 \"PGAM dimers (PGAM1,2) isomerise 2PG to 3PG\"", "Reactome:R-HSA-71654 \"3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate\"", "RHEA:15901" ], "previous": [ "Reactome:R-HSA-71445 \"PGAM dimers (PGAM1,2) isomerise 2PG to 3PG\"", "Reactome:R-HSA-71654 \"3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate\"", "RHEA:15901" ] } } }, { "id": "GO:0004674", "name": "protein serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.-", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"" ], "previous": [ "EC:2.7.11.1", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"" ] } } }, { "id": "GO:0008396", "name": "oxysterol 7-alpha-hydroxylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-191972 \"27-hydroxycholesterol is 7alpha-hydroxylated\"", "Reactome:R-HSA-192065 \"CYP7B1 7-hydroxylates 25OH-CHOL\"", "Reactome:R-HSA-192178 \"CYP39A1 7-hydroxylates 24OH-CHOL\"", "Reactome:R-HSA-5602885 \"Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL\"", "RHEA:68740" ], "previous": [ "Reactome:R-HSA-191972 \"27-hydroxycholesterol is 7alpha-hydroxylated\"", "Reactome:R-HSA-192065 \"CYP7B1 7-hydroxylates 25OH-CHOL\"", "Reactome:R-HSA-192178 \"CYP39A1 7-hydroxylates 24OH-CHOL\"", "Reactome:R-HSA-5602885 \"Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL\"" ] } } }, { "id": "GO:0008397", "name": "sterol 12-alpha-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.14.139", "RHEA:46752" ], "previous": [ "EC:1.14.14.139" ] } } }, { "id": "GO:0008412", "name": "4-hydroxybenzoate polyprenyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.5.1.39", "MetaCyc:RXN-11368", "RHEA:44504" ], "previous": [ "EC:2.5.1.39", "MetaCyc:RXN-11368", "Reactome:R-HSA-2162192 \"COQ2 ligates all-E-10PrP2 to PHB\"", "RHEA:44504" ] } } }, { "id": "GO:0008467", "name": "[heparan sulfate]-glucosamine 3-sulfotransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2076383 \"HS3ST1 sulfates GlcN at C3 in heparan sulfate\"", "Reactome:R-HSA-2076611 \"HS3STs sulfate GlcN at C3 in heparan sulfate\"", "RHEA:15461" ], "previous": [ "EC:2.8.2.23", "MetaCyc:2.8.2.23-RXN", "Reactome:R-HSA-2076383 \"HS3ST1 sulfates GlcN at C3 in heparan sulfate\"", "Reactome:R-HSA-2076611 \"HS3STs sulfate GlcN at C3 in heparan sulfate\"" ] } } }, { "id": "GO:0008695", "name": "3-phenylpropionate dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.12.19", "MetaCyc:HCAMULTI-RXN", "RHEA:20357", "UM-BBD_enzymeID:e0307" ], "previous": [ "EC:1.14.12.19", "MetaCyc:HCAMULTI-RXN", "RHEA:20357", "UM-BBD_enzymeID:r0434" ] } } }, { "id": "GO:0008942", "name": "nitrite reductase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377" ], "previous": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377", "RHEA:24632" ] } } }, { "id": "GO:0010291", "name": "beta-carotene 3-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.15.24", "MetaCyc:RXN1F-152", "RHEA:30331" ], "previous": "N/A" } } }, { "id": "GO:0016303", "name": "1-phosphatidylinositol-3-kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.137", "KEGG_REACTION:R03362", "MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN", "Reactome:R-HSA-109699 \"PI3K-containing complexes phosphorylate PIP2 to PIP3\"", "Reactome:R-HSA-1433514 \"Synthesis of PIP3 from PIP2 by PI3K\"", "Reactome:R-HSA-1675939 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane\"", "Reactome:R-HSA-1675961 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane\"", "Reactome:R-HSA-1676024 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane\"", "Reactome:R-HSA-2045911 \"BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3\"", "Reactome:R-HSA-5672012 \"Beclin-1 complex phosphorylates PtdIns\"", "Reactome:R-HSA-6798174 \"PIK3C3:PIK3R4 phosphorylates PI to PI3P\"", "Reactome:R-HSA-9670433 \"KIT mutants:PI3K catalyze synthesis of PIP3\"", "Reactome:R-HSA-9680389 \"CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2\"", "RHEA:12709" ], "previous": [ "EC:2.7.1.137", "KEGG_REACTION:R03362", "MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN", "Reactome:R-HSA-109699 \"PI3K-containing complexes phosphorylate PIP2 to PIP3\"", "Reactome:R-HSA-1433514 \"Synthesis of PIP3 from PIP2 by PI3K\"", "Reactome:R-HSA-1675939 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane\"", "Reactome:R-HSA-1675961 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane\"", "Reactome:R-HSA-1676024 \"PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane\"", "Reactome:R-HSA-2045911 \"BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3\"", "Reactome:R-HSA-5672012 \"Beclin-1 complex phosphorylates PtdIns\"", "Reactome:R-HSA-6798174 \"PIK3C3:PIK3R4 phosphorylates PI to PI3P\"", "Reactome:R-HSA-9670433 \"KIT mutants:PI3K catalyze synthesis of PIP3\"", "Reactome:R-HSA-9680389 \"CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2\"", "RHEA:12709", "Wikipedia:Phosphoinositide_3-kinase" ] } } }, { "id": "GO:0017040", "name": "N-acylsphingosine amidohydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"", "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"", "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"", "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"", "RHEA:20856" ], "previous": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"", "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"", "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"", "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"", "Reactome:R-HSA-428262 \"ACER3 hydrolyzes phytoceramide\"", "RHEA:20856" ] } } }, { "id": "GO:0017095", "name": "heparan sulfate 6-sulfotransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2076419 \"HS6STs sulfate GlcN at C6 in heparan sulfate/heparin\"", "RHEA:56604" ], "previous": [ "Reactome:R-HSA-2076419 \"HS6STs sulfate GlcN at C6 in heparan sulfate/heparin\"" ] } } }, { "id": "GO:0018591", "name": "methyl tertiary butyl ether 3-monooxygenase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r1023" ], "previous": "N/A" } } }, { "id": "GO:0018594", "name": "tert-butanol 2-monooxygenase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r0615" ], "previous": "N/A" } } }, { "id": "GO:0018755", "name": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r1414" ], "previous": "N/A" } } }, { "id": "GO:0018812", "name": "3-hydroxyacyl-CoA dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.74", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:33767" ], "previous": [ "EC:4.2.1.74", "MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:33767" ] } } }, { "id": "GO:0019833", "name": "ice nucleation activity", "changes": { "xrefs": { "current": [ "TC:9.B.133.1.1" ], "previous": "N/A" } } }, { "id": "GO:0035241", "name": "protein-arginine omega-N monomethyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.321", "RHEA:48100" ], "previous": [ "EC:2.1.1.321", "MetaCyc:2.1.1.124-RXN", "RHEA:48100" ] } } }, { "id": "GO:0035244", "name": "protein-arginine C-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.379", "RHEA:66028" ], "previous": [ "EC:2.1.1.379", "RESID:AA0272", "RHEA:66028" ] } } }, { "id": "GO:0036185", "name": "13-lipoxin reductase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2161844 \"15k-LXA4 is reduced to dhk-LXA4 by PTGR1\"", "RHEA:41592" ], "previous": [ "Reactome:R-HSA-2161844 \"15k-LXA4 is reduced to dhk-LXA4 by PTGR1\"" ] } } }, { "id": "GO:0042768", "name": "ecdysteroid 2-hydroxylase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:RXN-14679" ] } } }, { "id": "GO:0043786", "name": "cinnamate reductase activity", "changes": { "xrefs": { "current": [ "RHEA:50944" ], "previous": "N/A" } } }, { "id": "GO:0046905", "name": "15-cis-phytoene synthase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-13323", "RHEA:34475" ], "previous": [ "RHEA:34479" ] } } }, { "id": "GO:0047403", "name": "lacto-N-biosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.140", "MetaCyc:RXN-8731", "RHEA:21568" ], "previous": [ "EC:3.2.1.140", "RHEA:21568" ] } } }, { "id": "GO:0047792", "name": "cyanohydrin beta-glucosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.85", "MetaCyc:RXN-743", "RHEA:12853" ], "previous": [ "EC:2.4.1.85", "RHEA:12853" ] } } }, { "id": "GO:0050108", "name": "monoterpenyl-diphosphatase activity", "changes": { "xrefs": { "current": [ "MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN", "RHEA:81371" ], "previous": [ "MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN" ] } } }, { "id": "GO:0051269", "name": "alpha-ketoester reductase (NADPH) activity", "changes": { "xrefs": { "current": [ "RHEA:80767" ], "previous": "N/A" } } }, { "id": "GO:0051996", "name": "squalene synthase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:2.5.1.21", "MetaCyc:RXN66-281" ], "previous": [ "EC:2.5.1.21", "MetaCyc:RXN66-281", "Reactome:R-HSA-191402 \"Reduction of presqualene diphosphate to form squalene\"", "Reactome:R-HSA-191405 \"Two FPP molecules dimerize to form presqualene diphosphate\"" ] } } }, { "id": "GO:0052849", "name": "curcumin reductase (NADP+) activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN0-6676", "RHEA:34815" ], "previous": [ "EC:1.3.1.n3", "MetaCyc:RXN0-6676" ] } } }, { "id": "GO:0052856", "name": "NAD(P)HX epimerase activity", "changes": { "xrefs": { "current": [ "EC:5.1.99.6" ], "previous": [ "EC:5.1.99.6", "Reactome:R-HSA-6806966 \"APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX\"" ] } } }, { "id": "GO:0052903", "name": "N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity", "changes": { "xrefs": { "current": [ "EC:1.5.3.13", "KEGG_REACTION:R03899", "MetaCyc:RXN-12090" ], "previous": [ "EC:1.5.3.13", "KEGG_REACTION:R03899", "MetaCyc:RXN-12090", "Reactome:R-HSA-141348 \"PAO:FAD oxidises NASPM to PTCN\"", "Reactome:R-HSA-141351 \"PAOX:FAD oxidises NASPN to SPM\"" ] } } }, { "id": "GO:0055056", "name": "D-glucose transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429094 \"SLC2A6,8,10,12 transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-450095 \"GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region\"", "Reactome:R-HSA-5339524 \"GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632804 \"SLC2A1 tetramer does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632871 \"Defective SLC2A10 does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981553 \"GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981564 \"GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981570 \"GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981574 \"GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol\"" ], "previous": [ "Reactome:R-HSA-429094 \"SLC2A6,8,10,12 transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-450095 \"GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region\"", "Reactome:R-HSA-499981 \"Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2\"", "Reactome:R-HSA-5339524 \"GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632804 \"SLC2A1 tetramer does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5632871 \"Defective SLC2A10 does not transport Glc from extracellular region to cytosol\"", "Reactome:R-HSA-5653873 \"SLC2A1 tetramer transports Glc from cytosol to Golgi lumen\"", "Reactome:R-HSA-8981553 \"GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981564 \"GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981570 \"GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol\"", "Reactome:R-HSA-8981574 \"GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol\"" ] } } }, { "id": "GO:0062101", "name": "peptidyl-aspartic acid 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RHEA:11508" ], "previous": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RESID:AA0026", "RHEA:11508" ] } } }, { "id": "GO:0070330", "name": "aromatase activity", "changes": { "xrefs": { "current": [ "EC:1.14.14.14" ], "previous": [ "EC:1.14.14.14", "UM-BBD_reactionID:r1132", "UM-BBD_reactionID:r1137" ] } } }, { "id": "GO:0090555", "name": "phosphatidylethanolamine flippase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "RHEA:66132" ] } } }, { "id": "GO:0099618", "name": "UDP-glucuronate dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.305", "MetaCyc:RXN0-1861", "RHEA:24702" ], "previous": [ "EC:1.1.1.305", "RHEA:24702" ] } } }, { "id": "GO:0102140", "name": "heparan sulfate N-deacetylase activity", "changes": { "xrefs": { "current": [ "RHEA:70587" ], "previous": [ "MetaCyc:RXN-11557" ] } } }, { "id": "GO:0102175", "name": "3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.418", "MetaCyc:RXN-11928", "RHEA:34775" ], "previous": [ "MetaCyc:RXN-11928", "RHEA:34775" ] } } }, { "id": "GO:0102274", "name": "glutathione S-conjugate carboxypeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.17.25", "MetaCyc:RXN-12532", "RHEA:60448" ], "previous": [ "MetaCyc:RXN-12532" ] } } }, { "id": "GO:0103031", "name": "L-Ala-D/L-Glu epimerase activity", "changes": { "xrefs": { "current": [ "EC:5.1.1.20", "MetaCyc:RXN0-5228", "RHEA:28394" ], "previous": [ "MetaCyc:RXN0-5228", "RHEA:28394" ] } } }, { "id": "GO:0106359", "name": "2-hydroxyacyl-CoA lyase activity", "changes": { "xrefs": { "current": [ "EC:4.1.2.63" ], "previous": [ "EC:4.1.2.63", "MetaCyc:RXN66-471" ] } } }, { "id": "GO:0106364", "name": "4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:RXN3O-58", "RHEA:20361" ] } } }, { "id": "GO:0141207", "name": "peptide lactyltransferase (ATP-dependent) activity", "changes": { "xrefs": { "current": [ "RHEA:80271" ], "previous": "N/A" } } }, { "id": "GO:0141208", "name": "NAD-dependent protein lysine delactylase activity", "changes": { "xrefs": { "current": [ "RHEA:80287" ], "previous": "N/A" } } }, { "id": "GO:0141215", "name": "N-acetyltaurine hydrolase activity", "changes": { "xrefs": { "current": [ "RHEA:81107" ], "previous": "N/A" } } }, { "id": "GO:0160128", "name": "pH-gated monoatomic ion channel activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2671885 \"ASIC trimers:H+ transport extracellular Na+ to cytosol\"" ], "previous": [ "Reactome:R-HSA-2671885 \"ASIC trimers:H+ transport extracellular Na+ to cytosol\"", "Wikipedia:Acid-sensing_ion_channel" ] } } }, { "id": "GO:0160198", "name": "polyprenal reductase activity", "changes": { "xrefs": { "current": [ "EC:1.3.1.94", "MetaCyc:RXN-9971", "RHEA:80727" ], "previous": [ "EC:1.3.1.94", "MetaCyc:RXN-9971" ] } } }, { "id": "GO:0160216", "name": "protein lysine delactylase activity", "changes": { "xrefs": { "current": [ "RHEA:81387" ], "previous": "N/A" } } }, { "id": "GO:1990055", "name": "phenylacetaldehyde synthase activity", "changes": { "xrefs": { "current": [ "EC:4.1.1.109", "MetaCyc:RXN-8990", "RHEA:55532" ], "previous": [ "EC:4.1.1.109", "RHEA:55532" ] } } } ], "cellular_component": [ { "id": "GO:0062039", "name": "biofilm matrix", "changes": { "xrefs": { "current": [ "PMID:28955324" ], "previous": "N/A" } } } ] }, "relations": { "molecular_function": [ { "id": "GO:0000010", "name": "heptaprenyl diphosphate synthase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0000248", "name": "C-5 sterol desaturase activity", "changes": { "is_a": { "current": [ "GO:0070704" ], "previous": [ "GO:0016717", "GO:0070704" ] } } }, { "id": "GO:0000249", "name": "C-22 sterol desaturase (NADPH) activity", "changes": { "is_a": { "current": [ "GO:0070704" ], "previous": [ "GO:0016717", "GO:0070704" ] } } }, { "id": "GO:0000252", "name": "3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity", "changes": { "is_a": { "current": [ "GO:0033764" ], "previous": [ "GO:0016616" ] } } }, { "id": "GO:0000253", "name": "3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "changes": { "is_a": { "current": [ "GO:0033764" ], "previous": [ "GO:0016616" ] } } }, { "id": "GO:0001537", "name": "dermatan 4-sulfotransferase activity", "changes": { "is_a": { "current": [ "GO:0120534" ], "previous": [ "GO:0008146" ] } } }, { "id": "GO:0001882", "name": "nucleoside binding", "changes": { "is_a": { "current": [ "GO:0097367", "GO:1901363" ], "previous": [ "GO:0097159", "GO:0097367", "GO:1901363" ] } } }, { "id": "GO:0002054", "name": "nucleobase binding", "changes": { "is_a": { "current": [ "GO:1901363" ], "previous": [ "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0003676", "name": "nucleic acid binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0003678", "name": "DNA helicase activity", "changes": { "relationship": { "current": "N/A", "previous": [ "part_of GO:0032508" ] } } }, { "id": "GO:0003707", "name": "nuclear steroid receptor activity", "changes": { "relationship": { "current": [ "part_of GO:0030518" ], "previous": [ "part_of GO:0043401" ] } } }, { "id": "GO:0004161", "name": "dimethylallyltranstransferase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0004230", "name": "glutamyl aminopeptidase activity", "changes": { "is_a": { "current": [ "GO:0004177" ], "previous": "N/A" } } }, { "id": "GO:0004311", "name": "geranylgeranyl diphosphate synthase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0004337", "name": "(2E,6E)-farnesyl diphosphate synthase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0004508", "name": "steroid 17-alpha-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016712" ], "previous": [ "GO:0008395", "GO:0016705" ] } } }, { "id": "GO:0004509", "name": "steroid 21-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016712" ], "previous": [ "GO:0008395", "GO:0016705" ] } } }, { "id": "GO:0004883", "name": "nuclear glucocorticoid receptor activity", "changes": { "is_a": { "current": [ "GO:0003707" ], "previous": [ "GO:0004879" ] } } }, { "id": "GO:0005330", "name": "dopamine:sodium symporter activity", "changes": { "is_a": { "current": [ "GO:0008504", "GO:0015378" ], "previous": [ "GO:0008504", "GO:0015378", "GO:1901618" ] } } }, { "id": "GO:0005334", "name": "norepinephrine:sodium symporter activity", "changes": { "is_a": { "current": [ "GO:0008504", "GO:0015101", "GO:0015378" ], "previous": [ "GO:0008504", "GO:0015101", "GO:0015378", "GO:1901618" ] } } }, { "id": "GO:0005335", "name": "serotonin:sodium:chloride symporter activity", "changes": { "is_a": { "current": [ "GO:0008504", "GO:0015378" ], "previous": [ "GO:0008504", "GO:0015378", "GO:1901618" ] } } }, { "id": "GO:0005461", "name": "UDP-glucuronate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015165", "GO:0046943" ], "previous": [ "GO:0015165" ] } } }, { "id": "GO:0005496", "name": "steroid binding", "changes": { "is_a": { "current": [ "GO:0008289" ], "previous": [ "GO:0008289", "GO:0097159" ] } } }, { "id": "GO:0005527", "name": "macrolide binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0005542", "name": "folic acid binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:0031406", "GO:0033218", "GO:0072341", "GO:1901363" ], "previous": [ "GO:0019842", "GO:0031406", "GO:0033218", "GO:0072341", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0008123", "name": "cholesterol 7-alpha-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008387", "GO:0016712" ], "previous": [ "GO:0008387", "GO:0016709" ] } } }, { "id": "GO:0008390", "name": "testosterone 16-alpha-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016712" ], "previous": [ "GO:0008395", "GO:0016705" ] } } }, { "id": "GO:0008412", "name": "4-hydroxybenzoate polyprenyltransferase activity", "changes": { "is_a": { "current": [ "GO:0004659" ], "previous": [ "GO:0002094" ] } } }, { "id": "GO:0008431", "name": "vitamin E binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:1901363" ], "previous": [ "GO:0019842", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0008658", "name": "penicillin binding", "changes": { "is_a": { "current": [ "GO:0033218", "GO:0033293", "GO:1901363", "GO:1901681" ], "previous": [ "GO:0033218", "GO:0033293", "GO:0097159", "GO:1901363", "GO:1901681" ] } } }, { "id": "GO:0008834", "name": "ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity", "changes": { "is_a": { "current": [ "GO:0045547" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0008886", "name": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity", "changes": { "is_a": { "current": [ "GO:0120533" ], "previous": [ "GO:0016620" ] } } }, { "id": "GO:0009374", "name": "biotin binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:0033218", "GO:0033293", "GO:1901363", "GO:1901681" ], "previous": [ "GO:0019842", "GO:0033218", "GO:0033293", "GO:0097159", "GO:1901363", "GO:1901681" ] } } }, { "id": "GO:0010013", "name": "N-1-naphthylphthalamic acid binding", "changes": { "is_a": { "current": [ "GO:0033218", "GO:0033293" ], "previous": [ "GO:0033218", "GO:0033293", "GO:0097159" ] } } }, { "id": "GO:0015125", "name": "bile acid transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028", "GO:0170055" ], "previous": [ "GO:0008028", "GO:0170055", "GO:1901618" ] } } }, { "id": "GO:0015129", "name": "lactate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028" ], "previous": [ "GO:0008028", "GO:1901618" ] } } }, { "id": "GO:0015166", "name": "polyol transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0022857" ], "previous": [ "GO:1901618" ] } } }, { "id": "GO:0015530", "name": "shikimate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028" ], "previous": [ "GO:0008028", "GO:1901618" ] } } }, { "id": "GO:0015551", "name": "3-hydroxyphenyl propanoate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0022857" ], "previous": [ "GO:1901618" ] } } }, { "id": "GO:0015665", "name": "alcohol transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0022857" ], "previous": [ "GO:1901618" ] } } }, { "id": "GO:0016172", "name": "antifreeze activity", "changes": { "is_a": { "current": [ "GO:0050825" ], "previous": "N/A" } } }, { "id": "GO:0016285", "name": "alanyl aminopeptidase activity", "changes": { "is_a": { "current": [ "GO:0004177" ], "previous": "N/A" } } }, { "id": "GO:0016596", "name": "thienylcyclohexylpiperidine binding", "changes": { "is_a": { "current": [ "GO:1901681" ], "previous": [ "GO:0097159", "GO:1901681" ] } } }, { "id": "GO:0018592", "name": "4-nitrocatechol 4-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016709" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0018679", "name": "dibenzothiophene sulfone monooxygenase (NADH) activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0019811", "name": "cocaine binding", "changes": { "is_a": { "current": [ "GO:0043169", "GO:1901363" ], "previous": [ "GO:0043169", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0019833", "name": "ice nucleation activity", "changes": { "is_a": { "current": [ "GO:0050825" ], "previous": "N/A" } } }, { "id": "GO:0030284", "name": "nuclear estrogen receptor activity", "changes": { "is_a": { "current": [ "GO:0003707" ], "previous": [ "GO:0004879" ] } } }, { "id": "GO:0030343", "name": "vitamin D3 25-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008395" ], "previous": [ "GO:0070643" ] } } }, { "id": "GO:0030975", "name": "thiamine binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:0043169", "GO:0043178", "GO:1901363", "GO:1901681" ], "previous": [ "GO:0019842", "GO:0043169", "GO:0043178", "GO:0097159", "GO:1901363", "GO:1901681" ] } } }, { "id": "GO:0030976", "name": "thiamine pyrophosphate binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:0043168", "GO:0043169", "GO:0050997", "GO:1901363", "GO:1901681" ], "previous": [ "GO:0019842", "GO:0043168", "GO:0043169", "GO:0050997", "GO:0097159", "GO:1901363", "GO:1901681" ] } } }, { "id": "GO:0031073", "name": "cholesterol 26-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016716" ], "previous": [ "GO:0008395" ] } } }, { "id": "GO:0031405", "name": "lipoic acid binding", "changes": { "is_a": { "current": [ "GO:0005504", "GO:1901363", "GO:1901681" ], "previous": [ "GO:0005504", "GO:0097159", "GO:1901363", "GO:1901681" ] } } }, { "id": "GO:0031418", "name": "L-ascorbic acid binding", "changes": { "is_a": { "current": [ "GO:0019842", "GO:0031406", "GO:0048029", "GO:1901363" ], "previous": [ "GO:0019842", "GO:0031406", "GO:0048029", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0031925", "name": "pyridoxal transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015101" ], "previous": [ "GO:0015101", "GO:1901618" ] } } }, { "id": "GO:0031926", "name": "pyridoxal phosphate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008514", "GO:0015605" ], "previous": [ "GO:0008514", "GO:0015605", "GO:1901618" ] } } }, { "id": "GO:0031927", "name": "pyridoxamine transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015101" ], "previous": [ "GO:0015101", "GO:1901618" ] } } }, { "id": "GO:0031928", "name": "pyridoxine transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0022857" ], "previous": [ "GO:1901618" ] } } }, { "id": "GO:0033294", "name": "ectoine binding", "changes": { "is_a": { "current": [ "GO:0033293", "GO:1901363" ], "previous": [ "GO:0033293", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0033295", "name": "hydroxyectoine binding", "changes": { "is_a": { "current": [ "GO:0033293", "GO:0043178", "GO:0050997", "GO:1901363" ], "previous": [ "GO:0033293", "GO:0043178", "GO:0050997", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0033703", "name": "3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity", "changes": { "is_a": { "current": [ "GO:0033764" ], "previous": [ "GO:0016616" ] } } }, { "id": "GO:0033704", "name": "3-beta-hydroxy-5-alpha-steroid dehydrogenase (NADP+) activity", "changes": { "is_a": { "current": [ "GO:0033764" ], "previous": [ "GO:0016616" ] } } }, { "id": "GO:0033782", "name": "24S-hydroxycholesterol 7-alpha-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008387", "GO:0016712" ], "previous": [ "GO:0008396", "GO:0016712" ] } } }, { "id": "GO:0033783", "name": "25-hydroxycholesterol 7-alpha-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008387", "GO:0016712" ], "previous": [ "GO:0008396", "GO:0016712" ] } } }, { "id": "GO:0034041", "name": "ABC-type sterol transporter activity", "changes": { "is_a": { "current": [ "GO:0034040", "GO:0140359" ], "previous": [ "GO:0034040", "GO:0140359", "GO:1901618" ] } } }, { "id": "GO:0034481", "name": "chondroitin sulfotransferase activity", "changes": { "is_a": { "current": [ "GO:0050698" ], "previous": [ "GO:0008146" ] } } }, { "id": "GO:0034483", "name": "heparan sulfate sulfotransferase activity", "changes": { "is_a": { "current": [ "GO:0050698" ], "previous": [ "GO:0008146" ] } } }, { "id": "GO:0034617", "name": "tetrahydrobiopterin binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0034739", "name": "histone H4K16 deacetylase activity, hydrolytic mechanism", "changes": { "is_a": { "current": [ "GO:0141051", "GO:0141221" ], "previous": [ "GO:0141051" ] } } }, { "id": "GO:0035273", "name": "phthalate binding", "changes": { "is_a": { "current": [ "GO:0031406" ], "previous": [ "GO:0031406", "GO:0097159" ] } } }, { "id": "GO:0035274", "name": "diphenyl phthalate binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0035275", "name": "dibutyl phthalate binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0035302", "name": "ecdysteroid 25-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016712" ], "previous": [ "GO:0008395" ] } } }, { "id": "GO:0035923", "name": "flurbiprofen binding", "changes": { "is_a": { "current": [ "GO:0031406" ], "previous": [ "GO:0031406", "GO:0097159" ] } } }, { "id": "GO:0036310", "name": "ATP-dependent DNA/DNA annealing activity", "changes": { "is_a": { "current": [ "GO:0008094", "GO:1990814" ], "previous": [ "GO:0140657", "GO:1990814" ] } } }, { "id": "GO:0036423", "name": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0042767", "name": "ecdysteroid 22-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016713" ], "previous": [ "GO:0008395" ] } } }, { "id": "GO:0042931", "name": "enterobactin transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008514", "GO:0015343" ], "previous": [ "GO:0008514", "GO:0015343", "GO:1901618" ] } } }, { "id": "GO:0042934", "name": "achromobactin transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015343", "GO:0042887", "GO:0046943" ], "previous": [ "GO:0015343", "GO:0042887", "GO:0046943", "GO:1901618" ] } } }, { "id": "GO:0043544", "name": "lipoamide binding", "changes": { "is_a": { "current": [ "GO:0033218", "GO:1901681" ], "previous": [ "GO:0033218", "GO:0097159", "GO:1901681" ] } } }, { "id": "GO:0043546", "name": "molybdopterin cofactor binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0043878", "name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "changes": { "is_a": { "current": [ "GO:0120533" ], "previous": [ "GO:0016620" ] } } }, { "id": "GO:0043924", "name": "suramin binding", "changes": { "is_a": { "current": [ "GO:0033218", "GO:0043168", "GO:0043177", "GO:1901681" ], "previous": [ "GO:0033218", "GO:0043168", "GO:0043177", "GO:0097159", "GO:1901681" ] } } }, { "id": "GO:0044687", "name": "geranylfarnesyl diphosphate synthase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0044875", "name": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "changes": { "is_a": { "current": [ "GO:0004497", "GO:0016705" ], "previous": [ "GO:0016705" ] } } }, { "id": "GO:0045130", "name": "keratan sulfotransferase activity", "changes": { "is_a": { "current": [ "GO:0050698" ], "previous": [ "GO:0008146" ] } } }, { "id": "GO:0045547", "name": "ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0046428", "name": "1,4-dihydroxy-2-naphthoate polyprenyltransferase activity", "changes": { "is_a": { "current": [ "GO:0004659" ], "previous": [ "GO:0002094" ] } } }, { "id": "GO:0046905", "name": "15-cis-phytoene synthase activity", "changes": { "is_a": { "current": [ "GO:0004659" ], "previous": [ "GO:0016462" ] } } }, { "id": "GO:0046906", "name": "tetrapyrrole binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0047035", "name": "testosterone dehydrogenase (NAD+) activity", "changes": { "is_a": { "current": [ "GO:0030283", "GO:0044594" ], "previous": [ "GO:0030283" ] } } }, { "id": "GO:0047045", "name": "testosterone 17-beta-dehydrogenase (NADP+) activity", "changes": { "is_a": { "current": [ "GO:0030283", "GO:0072582" ], "previous": [ "GO:0033764" ] } } }, { "id": "GO:0047096", "name": "androst-4-ene-3,17-dione monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0004508" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0047295", "name": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "changes": { "is_a": { "current": [ "GO:0004659" ], "previous": [ "GO:0002094" ] } } }, { "id": "GO:0047863", "name": "dimethylallylcistransferase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0047882", "name": "estradiol 6-beta-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016705" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0050016", "name": "kynurenine 7,8-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0004497", "GO:0016705" ], "previous": [ "GO:0016705" ] } } }, { "id": "GO:0050046", "name": "delta7-sterol 5(6)-desaturase activity", "changes": { "is_a": { "current": [ "GO:0070704" ], "previous": [ "GO:0016717", "GO:0070704" ] } } }, { "id": "GO:0050212", "name": "progesterone 11-alpha-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0050214" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0050214", "name": "progesterone monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016705" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0050267", "name": "rubber cis-polyprenylcistransferase activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0002094" ] } } }, { "id": "GO:0050292", "name": "steroid 9-alpha-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0008395", "GO:0016705" ], "previous": [ "GO:0004497", "GO:0016705" ] } } }, { "id": "GO:0050604", "name": "taxadiene 5-alpha-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0004497", "GO:0016705" ], "previous": [ "GO:0016705" ] } } }, { "id": "GO:0050809", "name": "diazepam binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:0097159" ] } } }, { "id": "GO:0051378", "name": "serotonin binding", "changes": { "is_a": { "current": [ "GO:0043169", "GO:0043176", "GO:1901363" ], "previous": [ "GO:0043169", "GO:0043176", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0051381", "name": "histamine binding", "changes": { "is_a": { "current": [ "GO:0043169", "GO:1901363" ], "previous": [ "GO:0043169", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0051870", "name": "methotrexate binding", "changes": { "is_a": { "current": [ "GO:0031406", "GO:0033218", "GO:1901363" ], "previous": [ "GO:0031406", "GO:0033218", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0051871", "name": "dihydrofolic acid binding", "changes": { "is_a": { "current": [ "GO:0031406", "GO:0072341", "GO:1901363" ], "previous": [ "GO:0031406", "GO:0072341", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0052922", "name": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0052923", "name": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0052924", "name": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "changes": { "is_a": { "current": [ "GO:0120531" ], "previous": [ "GO:0004659" ] } } }, { "id": "GO:0061628", "name": "histone H3K27me3 reader activity", "changes": { "is_a": { "current": [ "GO:0140006" ], "previous": [ "GO:0035064" ] } } }, { "id": "GO:0062072", "name": "histone H3K9me3 reader activity", "changes": { "is_a": { "current": [ "GO:0140006" ], "previous": [ "GO:0035064" ] } } }, { "id": "GO:0062179", "name": "vitamin D 23-hydroxylase activity", "changes": { "is_a": { "current": [ 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"GO:1900620", "GO:1901617" ] } } }, { "id": "GO:0140883", "name": "symbiont-mediated activation of host reticulophagy", "changes": { "is_a": { "current": [ "GO:0039520" ], "previous": [ "GO:0044068", "GO:0141088" ] } } }, { "id": "GO:0140976", "name": "host defense response against symbiont-mediated perturbation of plasma membrane integrity", "changes": { "is_a": { "current": [ "GO:0140546" ], "previous": [ "GO:0098542" ] } } }, { "id": "GO:0141023", "name": "symbiont-mediated disruption of host cell-cell adhesion", "changes": { "is_a": { "current": [ "GO:0044068" ], "previous": [ "GO:0044003" ] } } }, { "id": "GO:0141073", "name": "symbiont-mediated perturbation of host opsonization", "changes": { "is_a": { "current": [ "GO:0052031" ], "previous": [ "GO:0044003" ] } } }, { "id": "GO:0141083", "name": "symbiont-mediated suppression of host reactive oxygen species generation", "changes": { "is_a": { "current": [ "GO:0044068", "GO:0052031" ], "previous": [ "GO:0044003" ] } } }, { "id": 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host phagosome acidification", "changes": { "is_a": { "current": [ "GO:0052031" ], "previous": [ "GO:0044003" ] } } }, { "id": "GO:0141204", "name": "dipeptide transmembrane transport from lysosomal lumen to cytosol", "changes": { "is_a": { "current": [ "GO:0015833", "GO:0170063" ], "previous": [ "GO:0007041", "GO:0015833", "GO:0034486" ] } } }, { "id": "GO:0150072", "name": "positive regulation of arginase activity", "changes": { "is_a": { "current": [ "GO:0051345" ], "previous": [ "GO:0051345", "GO:0150070" ] } } }, { "id": "GO:0150074", "name": "positive regulation of protein-glutamine gamma-glutamyltransferase activity", "changes": { "is_a": { "current": [ "GO:0051347" ], "previous": [ "GO:0051347", "GO:0150073" ] } } }, { "id": "GO:1900003", "name": "regulation of serine-type endopeptidase activity", "changes": { "is_a": { "current": [ "GO:0052548" ], "previous": [ "GO:0052548", "GO:1902571" ] } } }, { "id": "GO:1900005", "name": "positive regulation of serine-type endopeptidase activity", "changes": { "is_a": { "current": [ "GO:0010950", "GO:1900003" ], "previous": [ "GO:0010950", "GO:1900003", "GO:1902573" ] } } }, { "id": "GO:1900011", "name": "negative regulation of corticotropin-releasing hormone receptor activity", "changes": { "is_a": { "current": [ "GO:0009968", "GO:2000272" ], "previous": [ "GO:0009968", "GO:1900010", "GO:2000272" ] } } }, { "id": "GO:1900131", "name": "negative regulation of lipid binding", "changes": { "is_a": { "current": [ "GO:0051100" ], "previous": [ "GO:0051100", "GO:1900130" ] } } }, { "id": "GO:1900163", "name": "positive regulation of phospholipid scramblase activity", "changes": { "is_a": { "current": [ "GO:0110113" ], "previous": [ "GO:0110113", "GO:1900161" ] } } }, { "id": "GO:1900260", "name": "negative regulation of RNA-dependent RNA polymerase activity", "changes": { "is_a": { "current": [ "GO:0051348" ], "previous": [ "GO:0051348", "GO:1900259" ] } } }, { "id": "GO:1900264", "name": "positive regulation of DNA-directed DNA polymerase activity", "changes": { "is_a": { "current": [ "GO:0051347", "GO:2000573" ], "previous": [ "GO:0051347", "GO:1900262", "GO:2000573" ] } } }, { "id": "GO:1900609", "name": "F-9775A metabolic process", "changes": { "is_a": { "current": [ "GO:0018958", "GO:0030638" ], "previous": [ "GO:0018958", "GO:0030638", "GO:1901376" ] } } }, { "id": "GO:1900610", "name": "F-9775A catabolic process", "changes": { "is_a": { "current": [ "GO:0019336", "GO:0030640", "GO:1900609" ], "previous": [ "GO:0019336", "GO:0030640", "GO:1900609", "GO:1901377" ] } } }, { "id": "GO:1900611", "name": "F-9775A biosynthetic process", "changes": { "is_a": { "current": [ "GO:0030639", "GO:0046189", "GO:1900609" ], "previous": [ "GO:0030639", "GO:0046189", "GO:1900609", "GO:1901378" ] } } }, { "id": "GO:1900612", "name": "F-9775B metabolic process", "changes": { "is_a": { "current": [ "GO:0018958", "GO:0030638" ], "previous": [ "GO:0018958", "GO:0030638", "GO:1901376" ] } } }, { "id": "GO:1900613", "name": "F-9775B catabolic process", "changes": { "is_a": { "current": [ "GO:0019336", "GO:0030640", "GO:1900612" ], "previous": [ "GO:0019336", "GO:0030640", "GO:1900612", "GO:1901377" ] } } }, { "id": "GO:1900614", "name": "F-9775B biosynthetic process", "changes": { "is_a": { "current": [ "GO:0030639", "GO:0046189", "GO:1900612" ], "previous": [ "GO:0030639", "GO:0046189", "GO:1900612", "GO:1901378" ] } } }, { "id": "GO:1900772", "name": "fumitremorgin B biosynthetic process", "changes": { "is_a": { "current": [ "GO:0035835" ], "previous": [ "GO:0035835", "GO:1901378" ] } } }, { "id": "GO:1900796", "name": "terrequinone A biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009821", "GO:0120255", "GO:1901663" ], "previous": [ "GO:0009821", "GO:0120255", "GO:1901617", "GO:1901663" ] } } }, { "id": "GO:1900983", "name": "vindoline metabolic process", "changes": { "is_a": { "current": [ "GO:0046447", "GO:1900619", "GO:1902644" ], "previous": [ "GO:0046447", "GO:1900619", "GO:1901376", "GO:1902644" ] } } }, { "id": "GO:1900985", "name": "vindoline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009709", "GO:1900620", "GO:1900983", "GO:1902645" ], "previous": [ "GO:0009709", "GO:1900620", "GO:1900983", "GO:1901378", "GO:1902645" ] } } }, { "id": "GO:1900988", "name": "ajmaline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009709" ], "previous": [ "GO:0009709", "GO:1901617" ] } } }, { "id": "GO:1901012", "name": "(S)-reticuline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009708" ], "previous": [ "GO:0009708", "GO:1901617" ] } } }, { "id": "GO:1901183", "name": "positive regulation of camalexin biosynthetic process", "changes": { "is_a": { "current": [ "GO:0051176", "GO:0052322" ], "previous": [ "GO:0051176", "GO:0052322", "GO:1901182" ] } } }, { "id": "GO:1901252", "name": "regulation of intracellular transport of viral material", "changes": { "is_a": { "current": [ "GO:0043903", "GO:1903900" ], "previous": [ "GO:1903900" ] } } }, { "id": "GO:1901323", "name": "response to erythromycin", "changes": { "is_a": { "current": [ "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901700" ] } } }, { "id": "GO:1901324", "name": "response to trichodermin", "changes": { "is_a": { "current": [ "GO:0045472" ], "previous": [ "GO:0014070", "GO:0045472" ] } } }, { "id": "GO:1901325", "name": "response to antimycin A", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901327", "name": "response to tacrolimus", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901328", "name": "response to cytochalasin B", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901344", "name": "response to leptomycin B", "changes": { "is_a": { "current": [ "GO:0070542" ], "previous": [ "GO:0014070", "GO:0070542" ] } } }, { "id": "GO:1901355", "name": "response to rapamycin", "changes": { "is_a": { "current": [ "GO:0045472", "GO:0097305", "GO:1901654", "GO:1901698" ], "previous": [ "GO:0014070", "GO:0045472", "GO:0097305", "GO:1901654", "GO:1901698" ] } } }, { "id": "GO:1901423", "name": "response to benzene", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1901424", "name": "response to toluene", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1901426", "name": "response to furfural", "changes": { "is_a": { "current": [ "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901700" ] } } }, { "id": "GO:1901493", "name": "response to decalin", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1901497", "name": "response to diphenyl ether", "changes": { "is_a": { "current": [ "GO:0045472" ], "previous": [ "GO:0014070", "GO:0045472" ] } } }, { "id": "GO:1901498", "name": "response to tetralin", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1901501", "name": "response to xylene", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1901554", "name": "response to paracetamol", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901556", "name": "response to candesartan", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901557", "name": "response to fenofibrate", "changes": { "is_a": { "current": [ "GO:0045472", "GO:1901654" ], "previous": [ "GO:0014070", "GO:0045472", "GO:1901654" ] } } }, { "id": "GO:1901559", "name": "response to ribavirin", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901563", "name": "response to camptothecin", "changes": { "is_a": { "current": [ "GO:0043279", "GO:0097305" ], "previous": [ "GO:0014070", "GO:0043279", "GO:0097305" ] } } }, { "id": "GO:1901594", "name": "response to capsazepine", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901595", "name": "response to hesperadin", "changes": { "is_a": { "current": [ "GO:0014075", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0014075", "GO:1901700" ] } } }, { "id": "GO:1901597", "name": "response to carbendazim", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1901666", "name": "positive regulation of NAD+ ADP-ribosyltransferase activity", "changes": { "is_a": { "current": [ "GO:0010835", "GO:0051347" ], "previous": [ "GO:0051347", "GO:1901664" ] } } }, { "id": "GO:1901732", "name": "quercetin metabolic process", "changes": { "is_a": { "current": [ "GO:0051552" ], "previous": [ "GO:0051552", "GO:1901615" ] } } }, { "id": "GO:1901733", "name": "quercetin catabolic process", "changes": { "is_a": { "current": [ "GO:0046275", "GO:1901732" ], "previous": [ "GO:0046275", "GO:1901616", "GO:1901732" ] } } }, { "id": "GO:1901734", "name": "quercetin biosynthetic process", "changes": { "is_a": { "current": [ "GO:0051553", "GO:1901732" ], "previous": [ "GO:0051553", "GO:1901617", "GO:1901732" ] } } }, { "id": "GO:1901735", "name": "(R)-mevalonic acid metabolic process", "changes": { "is_a": { "current": [ "GO:0032787" ], "previous": [ "GO:0032787", "GO:1901615" ] } } }, { "id": "GO:1901736", "name": "(R)-mevalonic acid catabolic process", "changes": { "is_a": { "current": [ "GO:0072329", "GO:1901735" ], "previous": [ "GO:0072329", "GO:1901616", "GO:1901735" ] } } }, { "id": "GO:1901737", "name": "(R)-mevalonic acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0072330", "GO:1901735" ], "previous": [ "GO:0072330", "GO:1901617", "GO:1901735" ] } } }, { "id": "GO:1901824", "name": "alpha-carotene biosynthetic process", "changes": { "is_a": { "current": [ "GO:0016117", "GO:0016120" ], "previous": [ "GO:0016117", "GO:0016120", "GO:1901822" ] } } }, { "id": "GO:1901905", "name": "response to tamsulosin", "changes": { "is_a": { "current": [ "GO:0014075", "GO:0045472" ], "previous": [ "GO:0014070", "GO:0014075", "GO:0045472" ] } } }, { "id": "GO:1901919", "name": "positive regulation of exoribonuclease activity", "changes": { "is_a": { "current": [ "GO:0032075", "GO:0060700" ], "previous": [ "GO:1901917", "GO:1905779" ] } } }, { "id": "GO:1901986", "name": "response to ketamine", "changes": { "is_a": { "current": [ "GO:1901654", "GO:1901698" ], "previous": [ "GO:0014070", "GO:1901654", "GO:1901698" ] } } }, { "id": "GO:1902171", "name": "regulation of tocopherol cyclase activity", "changes": { "is_a": { "current": [ "GO:0050790" ], "previous": [ "GO:0031279" ] } } }, { "id": "GO:1902280", "name": "regulation of RNA helicase activity", "changes": { "is_a": { "current": [ "GO:0043462", "GO:0050790" ], "previous": [ "GO:0051095" ] } } }, { "id": "GO:1902347", "name": "response to strigolactone", "changes": { "is_a": { "current": [ "GO:0033993", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0033993", "GO:1901700" ] } } }, { "id": "GO:1902348", "name": "cellular response to strigolactone", "changes": { "is_a": { "current": [ "GO:0071396", "GO:1901701", "GO:1902347" ], "previous": [ "GO:0071396", "GO:0071407", "GO:1901701", "GO:1902347" ] } } }, { "id": "GO:1902349", "name": "response to chloroquine", "changes": { "is_a": { "current": [ "GO:1901698" ], "previous": [ "GO:0014070", "GO:1901698" ] } } }, { "id": "GO:1902350", "name": "cellular response to chloroquine", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1902349" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1902349" ] } } }, { "id": "GO:1902351", "name": "response to imidacloprid", "changes": { "is_a": { "current": [ "GO:1901698" ], "previous": [ "GO:0014070", "GO:1901698" ] } } }, { "id": "GO:1902384", "name": "glycyrrhetinate metabolic process", "changes": { "is_a": { "current": [ "GO:0019742", "GO:0032787", "GO:0042180" ], "previous": [ "GO:0019742", "GO:0032787", "GO:0042180", "GO:1901615" ] } } }, { "id": "GO:1902385", "name": "glycyrrhetinate catabolic process", "changes": { "is_a": { "current": [ "GO:0019741", "GO:0042182", "GO:0072329", "GO:1902384" ], "previous": [ "GO:0019741", "GO:0042182", "GO:0072329", "GO:1901616", "GO:1902384" ] } } }, { "id": "GO:1902386", "name": "glycyrrhetinate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0019745", "GO:0042181", "GO:0072330", "GO:1902384" ], "previous": [ "GO:0019745", "GO:0042181", "GO:0072330", "GO:1901617", "GO:1902384" ] } } }, { "id": "GO:1902415", "name": "regulation of mRNA binding", "changes": { "is_a": { "current": [ "GO:0051098" ], "previous": [ "GO:1905214" ] } } }, { "id": "GO:1902520", "name": "response to doxorubicin", "changes": { "is_a": { "current": [ "GO:0097305", "GO:1901654", "GO:1901698", "GO:1903416" ], "previous": [ "GO:0014070", "GO:0097305", "GO:1901654", "GO:1901698", "GO:1903416" ] } } }, { "id": "GO:1902521", "name": "response to etoposide", "changes": { "is_a": { "current": [ "GO:1904631" ], "previous": [ "GO:0014070", "GO:1904631" ] } } }, { "id": "GO:1902551", "name": "regulation of catalase activity", "changes": { "is_a": { "current": [ "GO:0051341" ], "previous": [ "GO:2000468" ] } } }, { "id": "GO:1902572", "name": "negative regulation of serine-type peptidase activity", "changes": { "is_a": { "current": [ "GO:0010466" ], "previous": [ "GO:0010466", "GO:1902571" ] } } }, { "id": "GO:1902596", "name": "negative regulation of DNA replication origin binding", "changes": { "is_a": { "current": [ "GO:0043392" ], "previous": [ "GO:0043392", "GO:1902595" ] } } }, { "id": "GO:1902597", "name": "positive regulation of DNA replication origin binding", "changes": { "is_a": { "current": [ "GO:0043388" ], "previous": [ "GO:0043388", "GO:1902595" ] } } }, { "id": "GO:1902607", "name": "negative regulation of large conductance calcium-activated potassium channel activity", "changes": { "is_a": { "current": [ "GO:1901017", "GO:2001258" ], "previous": [ "GO:1901017", "GO:1902606", "GO:2001258" ] } } }, { "id": "GO:1902608", "name": "positive regulation of large conductance calcium-activated potassium channel activity", "changes": { "is_a": { "current": [ "GO:1901018", "GO:2001259" ], "previous": [ "GO:1901018", "GO:1902606", "GO:2001259" ] } } }, { "id": "GO:1902609", "name": "(R)-2-hydroxy-alpha-linolenic acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006636", "GO:0042759" ], "previous": [ "GO:0006636", "GO:0042759", "GO:1901617" ] } } }, { "id": "GO:1902616", "name": "O-acyl-L-carnitine transmembrane transport", "changes": { "is_a": { "current": [ "GO:0015697", "GO:0055085" ], "previous": [ "GO:0006844", "GO:0055085" ] } } }, { "id": "GO:1902708", "name": "response to plumbagin", "changes": { "is_a": { "current": [ "GO:1901654" ], "previous": [ "GO:0014070", "GO:1901654" ] } } }, { "id": "GO:1902709", "name": "cellular response to plumbagin", "changes": { "is_a": { "current": [ "GO:1901655", "GO:1902708" ], "previous": [ "GO:0071407", "GO:1901655", "GO:1902708" ] } } }, { "id": "GO:1902800", "name": "positive regulation of phosphodiesterase I activity", "changes": { "is_a": { "current": [ "GO:0032075" ], "previous": [ "GO:1902799", "GO:1905779" ] } } }, { "id": "GO:1902933", "name": "isopentenol metabolic process", "changes": { "is_a": { "current": [ "GO:0120254" ], "previous": [ "GO:0120254", "GO:1901615" ] } } }, { "id": "GO:1902934", "name": "isopentenol biosynthetic process", "changes": { "is_a": { "current": [ "GO:0120255", "GO:1902933" ], "previous": [ "GO:0120255", "GO:1901617", "GO:1902933" ] } } }, { "id": "GO:1902943", "name": "positive regulation of voltage-gated chloride channel activity", "changes": { "is_a": { "current": [ "GO:1901529", "GO:1903797" ], "previous": [ "GO:1901529", "GO:1902941", "GO:1903797" ] } } }, { "id": "GO:1902960", "name": "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "changes": { "is_a": { "current": [ "GO:0010951", "GO:1902992" ], "previous": [ "GO:0010951", "GO:1902959", "GO:1902992", "GO:1905246" ] } } }, { "id": "GO:1902961", "name": "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process", "changes": { "is_a": { "current": [ "GO:0010950", "GO:1902993", "GO:1905247" ], "previous": [ "GO:0010950", "GO:1902959", "GO:1902993", "GO:1905247" ] } } }, { "id": "GO:1903013", "name": "response to differentiation-inducing factor 1", "changes": { "is_a": { "current": [ "GO:0045472", "GO:1901654" ], "previous": [ "GO:0014070", "GO:0045472", "GO:1901654" ] } } }, { "id": "GO:1903014", "name": "cellular response to differentiation-inducing factor 1", "changes": { "is_a": { "current": [ "GO:0071362", "GO:1901655", "GO:1903013" ], "previous": [ "GO:0071362", "GO:0071407", "GO:1901655", "GO:1903013" ] } } }, { "id": "GO:1903016", "name": "negative regulation of exo-alpha-sialidase activity", "changes": { "is_a": { "current": [ "GO:0051346" ], "previous": [ "GO:0051346", "GO:1903015" ] } } }, { "id": "GO:1903017", "name": "positive regulation of exo-alpha-sialidase activity", "changes": { "is_a": { "current": [ "GO:0051345" ], "previous": [ "GO:0051345", "GO:1903015" ] } } }, { "id": "GO:1903033", "name": "positive regulation of microtubule plus-end binding", "changes": { "is_a": { "current": [ "GO:1904528" ], "previous": [ "GO:1903031", "GO:1904528" ] } } }, { "id": "GO:1903165", "name": "response to polycyclic arene", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1903166", "name": "cellular response to polycyclic arene", "changes": { "is_a": { "current": [ "GO:0070887", "GO:1903165" ], "previous": [ "GO:0071407", "GO:1903165" ] } } }, { "id": "GO:1903281", "name": "positive regulation of calcium:sodium antiporter activity", "changes": { "is_a": { "current": [ "GO:1901021", "GO:2000651" ], "previous": [ "GO:1901021", "GO:1903279", "GO:2000651" ] } } }, { "id": "GO:1903282", "name": "regulation of glutathione peroxidase activity", "changes": { "is_a": { "current": [ "GO:0051341" ], "previous": [ "GO:2000468" ] } } }, { "id": "GO:1903300", "name": "negative regulation of hexokinase activity", "changes": { "is_a": { "current": [ "GO:0033673", "GO:0045912" ], "previous": [ "GO:0033673", "GO:0045912", "GO:1903299" ] } } }, { "id": "GO:1903301", "name": "positive regulation of hexokinase activity", "changes": { "is_a": { "current": [ "GO:0033674" ], "previous": [ "GO:0033674", "GO:1903299" ] } } }, { "id": "GO:1903412", "name": "response to bile acid", "changes": { "is_a": { "current": [ "GO:0033993", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0033993", "GO:1901700" ] } } }, { "id": "GO:1903413", "name": "cellular response to bile acid", "changes": { "is_a": { "current": [ "GO:0071396", "GO:1901701", "GO:1903412" ], "previous": [ "GO:0071396", "GO:0071407", "GO:1901701", "GO:1903412" ] } } }, { "id": "GO:1903442", "name": "response to lipoic acid", "changes": { "is_a": { "current": [ "GO:0070542" ], "previous": [ "GO:0014070", "GO:0070542" ] } } }, { "id": "GO:1903443", "name": "cellular response to lipoic acid", "changes": { "is_a": { "current": [ "GO:0071398", "GO:1903442" ], "previous": [ "GO:0071398", "GO:0071407", "GO:1903442" ] } } }, { "id": "GO:1903457", "name": "lactate catabolic process", "changes": { "is_a": { "current": [ "GO:0006089", "GO:0072329" ], "previous": [ "GO:0006089", "GO:0072329", "GO:1901616" ] } } }, { "id": "GO:1903491", "name": "response to simvastatin", "changes": { "is_a": { "current": [ "GO:0033993", "GO:0036273" ], "previous": [ "GO:0014070", "GO:0033993", "GO:0036273" ] } } }, { "id": "GO:1903492", "name": "response to acetylsalicylate", "changes": { "is_a": { "current": [ "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901700" ] } } }, { "id": "GO:1903493", "name": "response to clopidogrel", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1903494", "name": "response to dehydroepiandrosterone", "changes": { "is_a": { "current": [ "GO:0033993", "GO:0097305", "GO:1901654" ], "previous": [ "GO:0014070", "GO:0033993", "GO:0097305", "GO:1901654" ] } } }, { "id": "GO:1903495", "name": "cellular response to dehydroepiandrosterone", "changes": { "is_a": { "current": [ "GO:0071396", "GO:0097306", "GO:1901655", "GO:1903494" ], "previous": [ "GO:0071396", "GO:0071407", "GO:0097306", "GO:1901655", "GO:1903494" ] } } }, { "id": "GO:1903592", "name": "positive regulation of lysozyme activity", "changes": { "is_a": { "current": [ "GO:0051345" ], "previous": [ "GO:0051345", "GO:1903590" ] } } }, { "id": "GO:1903611", "name": "negative regulation of calcium-dependent ATPase activity", "changes": { "is_a": { "current": [ "GO:0032780" ], "previous": [ "GO:0032780", "GO:1903610" ] } } }, { "id": "GO:1903612", "name": "positive regulation of calcium-dependent ATPase activity", "changes": { "is_a": { "current": [ "GO:0032781" ], "previous": [ "GO:0032781", "GO:1903610" ] } } }, { "id": "GO:1903623", "name": "negative regulation of RNA polymerase III activity", "changes": { "is_a": { "current": [ "GO:0016480", "GO:0051348" ], "previous": [ "GO:0016480", "GO:0051348", "GO:1903622" ] } } }, { "id": "GO:1903755", "name": "positive regulation of SUMO transferase activity", "changes": { "is_a": { "current": [ "GO:0051347" ], "previous": [ "GO:0051347", "GO:1903182" ] } } }, { "id": "GO:1903914", "name": "negative regulation of fusion of virus membrane with host plasma membrane", "changes": { "is_a": { "current": [ "GO:0048525", "GO:0051129", "GO:1903913" ], "previous": [ "GO:0046597", "GO:0051129", "GO:1903913" ] }, "relationship": { "current": [ "negatively_regulates GO:0019064", "negatively_regulates GO:0046718" ], "previous": [ "negatively_regulates GO:0019064" ] } } }, { "id": "GO:1903925", "name": "response to bisphenol A", "changes": { "is_a": { "current": [ "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901700" ] } } }, { "id": "GO:1903926", "name": "cellular response to bisphenol A", "changes": { "is_a": { "current": [ "GO:1901701", "GO:1903925" ], "previous": [ "GO:0071407", "GO:1901701", "GO:1903925" ] } } }, { "id": "GO:1903934", "name": "positive regulation of DNA primase activity", "changes": { "is_a": { "current": [ "GO:0051054", "GO:0051347", "GO:1902680" ], "previous": [ "GO:0051054", "GO:0051347", "GO:1902680", "GO:1903932" ] } } }, { "id": "GO:1903996", "name": "negative regulation of non-membrane spanning protein tyrosine kinase activity", "changes": { "is_a": { "current": [ "GO:0061099" ], "previous": [ "GO:0061099", "GO:1903995" ] } } }, { "id": "GO:1904014", "name": "response to serotonin", "changes": { "is_a": { "current": [ "GO:0071867", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0071867", "GO:1901700" ] } } }, { "id": "GO:1904015", "name": "cellular response to serotonin", "changes": { "is_a": { "current": [ "GO:0071868", "GO:1901701", "GO:1904014" ], "previous": [ "GO:0071407", "GO:0071868", "GO:1901701", "GO:1904014" ] } } }, { "id": "GO:1904030", "name": "negative regulation of cyclin-dependent protein kinase activity", "changes": { "is_a": { "current": [ "GO:0006469" ], "previous": [ "GO:0006469", "GO:1904029" ] } } }, { "id": "GO:1904031", "name": "positive regulation of cyclin-dependent protein kinase activity", "changes": { "is_a": { "current": [ "GO:0045860" ], "previous": [ "GO:0045860", "GO:1904029" ] } } }, { "id": "GO:1904042", "name": "negative regulation of cystathionine beta-synthase activity", "changes": { "is_a": { "current": [ "GO:0051350" ], "previous": [ "GO:0051350", "GO:1904041" ] } } }, { "id": "GO:1904101", "name": "response to acadesine", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1904102", "name": "cellular response to acadesine", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1901701", "GO:1904101" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1901701", "GO:1904101" ] } } }, { "id": "GO:1904187", "name": "regulation of transformation of host cell by virus", "changes": { "is_a": { "current": [ "GO:0043903" ], "previous": [ "GO:0043903", "GO:0050792" ] } } }, { "id": "GO:1904188", "name": "negative regulation of transformation of host cell by virus", "changes": { "is_a": { "current": [ "GO:0048519", "GO:1904187" ], "previous": [ "GO:0048525", "GO:1904187" ] } } }, { "id": "GO:1904189", "name": "positive regulation of transformation of host cell by virus", "changes": { "is_a": { "current": [ "GO:0048518", "GO:1904187" ], "previous": [ "GO:0048524", "GO:1904187" ] } } }, { "id": "GO:1904227", "name": "negative regulation of glycogen synthase activity, transferring glucose-1-phosphate", "changes": { "is_a": { "current": [ "GO:0051348" ], "previous": [ "GO:0051348", "GO:1904226" ] } } }, { "id": "GO:1904233", "name": "negative regulation of aconitate hydratase activity", "changes": { "is_a": { "current": [ "GO:0051350" ], "previous": [ "GO:0051350", "GO:1904232" ] } } }, { "id": "GO:1904234", "name": "positive regulation of aconitate hydratase activity", "changes": { "is_a": { "current": [ "GO:0051349" ], "previous": [ "GO:0051349", "GO:1904232" ] } } }, { "id": "GO:1904246", "name": "negative regulation of polynucleotide adenylyltransferase activity", "changes": { "is_a": { "current": [ "GO:0051348" ], "previous": [ "GO:0051348", "GO:1904245" ] } } }, { "id": "GO:1904247", "name": "positive regulation of polynucleotide adenylyltransferase activity", "changes": { "is_a": { "current": [ "GO:0051347" ], "previous": [ "GO:0051347", "GO:1904245" ] } } }, { "id": "GO:1904307", "name": "response to desipramine", "changes": { "is_a": { "current": [ "GO:1901698" ], "previous": [ "GO:0014070", "GO:1901698" ] } } }, { "id": "GO:1904308", "name": "cellular response to desipramine", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1904307" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1904307" ] } } }, { "id": "GO:1904310", "name": "cellular response to cordycepin", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1901701", "GO:1904309" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1901701", "GO:1904309" ] } } }, { "id": "GO:1904321", "name": "response to forskolin", "changes": { "is_a": { "current": [ "GO:0033993", "GO:0097305", "GO:1901654" ], "previous": [ "GO:0014070", "GO:0033993", "GO:0097305", "GO:1901654" ] } } }, { "id": "GO:1904322", "name": "cellular response to forskolin", "changes": { "is_a": { "current": [ "GO:0071396", "GO:0097306", "GO:1901655", "GO:1904321" ], "previous": [ "GO:0071396", "GO:0071407", "GO:0097306", "GO:1901655", "GO:1904321" ] } } }, { "id": "GO:1904373", "name": "response to kainic acid", "changes": { "is_a": { "current": [ "GO:0043200", "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0043200", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1904374", "name": "cellular response to kainic acid", "changes": { "is_a": { "current": [ "GO:0071230", "GO:1901699", "GO:1901701", "GO:1904373" ], "previous": [ "GO:0071230", "GO:0071407", "GO:1901699", "GO:1901701", "GO:1904373" ] } } }, { "id": "GO:1904402", "name": "response to nocodazole", "changes": { "is_a": { "current": [ "GO:1901654", "GO:1901698" ], "previous": [ "GO:0014070", "GO:1901654", "GO:1901698" ] } } }, { "id": "GO:1904403", "name": "cellular response to nocodazole", "changes": { "is_a": { "current": [ "GO:1901655", "GO:1901699", "GO:1904402" ], "previous": [ "GO:0071407", "GO:1901655", "GO:1901699", "GO:1904402" ] } } }, { "id": "GO:1904425", "name": "negative regulation of GTP binding", "changes": { "is_a": { "current": [ "GO:0051100" ], "previous": [ "GO:0051100", "GO:1904424" ] } } }, { "id": "GO:1904426", "name": "positive regulation of GTP binding", "changes": { "is_a": { "current": [ "GO:0051099" ], "previous": [ "GO:0051099", "GO:1904424" ] } } }, { "id": "GO:1904434", "name": "positive regulation of ferrous iron binding", "changes": { "is_a": { "current": [ "GO:0051099" ], "previous": [ "GO:0051099", "GO:1904432" ] } } }, { "id": "GO:1904437", "name": "positive regulation of transferrin receptor binding", "changes": { "is_a": { "current": [ "GO:1900122" ], "previous": [ "GO:1900122", "GO:1904435" ] } } }, { "id": "GO:1904473", "name": "response to L-dopa", "changes": { "is_a": { "current": [ "GO:0043200", "GO:1901700", "GO:1904386" ], "previous": [ "GO:0014070", "GO:0043200", "GO:1901700", "GO:1904386" ] } } }, { "id": "GO:1904474", "name": "cellular response to L-dopa", "changes": { "is_a": { "current": [ "GO:0071230", "GO:1901701", "GO:1904387", "GO:1904473" ], "previous": [ "GO:0071230", "GO:0071407", "GO:1901701", "GO:1904387", "GO:1904473" ] } } }, { "id": "GO:1904481", "name": "response to tetrahydrofolate", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1904482", "name": "cellular response to tetrahydrofolate", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1901701", "GO:1904481" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1901701", "GO:1904481" ] } } }, { "id": "GO:1904530", "name": "negative regulation of actin filament binding", "changes": { "is_a": { "current": [ "GO:0032091", "GO:1904616" ], "previous": [ "GO:1904529", "GO:1904617" ] } } }, { "id": "GO:1904531", "name": "positive regulation of actin filament binding", "changes": { "is_a": { "current": [ "GO:0032092", "GO:1904616" ], "previous": [ "GO:1904529", "GO:1904618" ] } } }, { "id": "GO:1904560", "name": "response to diphenidol", "changes": { "is_a": { "current": [ "GO:0097305", "GO:1901698" ], "previous": [ "GO:0014070", "GO:0097305", "GO:1901698" ] } } }, { "id": "GO:1904561", "name": "cellular response to diphenidol", "changes": { "is_a": { "current": [ "GO:0097306", "GO:1901699", "GO:1904560" ], "previous": [ "GO:0071407", "GO:0097306", "GO:1901699", "GO:1904560" ] } } }, { "id": "GO:1904567", "name": "response to wortmannin", "changes": { "is_a": { "current": [ "GO:1901654" ], "previous": [ "GO:0014070", "GO:1901654" ] } } }, { "id": "GO:1904568", "name": "cellular response to wortmannin", "changes": { "is_a": { "current": [ "GO:1901655", "GO:1904567" ], "previous": [ "GO:0071407", "GO:1901655", "GO:1904567" ] } } }, { "id": "GO:1904604", "name": "negative regulation of advanced glycation end-product receptor activity", "changes": { "is_a": { "current": [ "GO:2000272" ], "previous": [ "GO:1904603", "GO:2000272" ] } } }, { "id": "GO:1904610", "name": "response to 3,3',4,4',5-pentachlorobiphenyl", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1904611", "name": "cellular response to 3,3',4,4',5-pentachlorobiphenyl", "changes": { "is_a": { "current": [ "GO:0070887", "GO:1904610" ], "previous": [ "GO:0071407", "GO:1904610" ] } } }, { "id": "GO:1904612", "name": "response to 2,3,7,8-tetrachlorodibenzodioxine", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1904613", "name": "cellular response to 2,3,7,8-tetrachlorodibenzodioxine", "changes": { "is_a": { "current": [ "GO:0070887", "GO:1904612" ], "previous": [ "GO:0071407", "GO:1904612" ] } } }, { "id": "GO:1904614", "name": "response to biphenyl", "changes": { "is_a": { "current": [ "GO:0042221" ], "previous": [ "GO:0014070" ] } } }, { "id": "GO:1904615", "name": "cellular response to biphenyl", "changes": { "is_a": { "current": [ "GO:0070887", "GO:1904614" ], "previous": [ "GO:0071407", "GO:1904614" ] } } }, { "id": "GO:1904636", "name": "response to ionomycin", "changes": { "is_a": { "current": [ "GO:0045472", "GO:0070542" ], "previous": [ "GO:0014070", "GO:0045472", "GO:0070542" ] } } }, { "id": "GO:1904637", "name": "cellular response to ionomycin", "changes": { "is_a": { "current": [ "GO:0071362", "GO:0071398", "GO:1904636" ], "previous": [ "GO:0071362", "GO:0071398", "GO:0071407", "GO:1904636" ] } } }, { "id": "GO:1904639", "name": "cellular response to resveratrol", "changes": { "is_a": { "current": [ "GO:1901701", "GO:1904638" ], "previous": [ "GO:0071407", "GO:1901701", "GO:1904638" ] } } }, { "id": "GO:1904641", "name": "response to dinitrophenol", "changes": { "is_a": { "current": [ "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1904642", "name": "cellular response to 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activity", "changes": { "is_a": { "current": [ "GO:0032074" ], "previous": [ "GO:0032074", "GO:1905777" ] } } }, { "id": "GO:1905795", "name": "cellular response to puromycin", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1901701", "GO:1905794" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1901701", "GO:1905794" ] } } }, { "id": "GO:1905834", "name": "response to pyrimidine ribonucleotide", "changes": { "is_a": { "current": [ "GO:0046683", "GO:1901698", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0046683", "GO:1901698", "GO:1901700" ] } } }, { "id": "GO:1905835", "name": "cellular response to pyrimidine ribonucleotide", "changes": { "is_a": { "current": [ "GO:1901699", "GO:1901701", "GO:1905834" ], "previous": [ "GO:0071407", "GO:1901699", "GO:1901701", "GO:1905834" ] } } }, { "id": "GO:1905919", "name": "negative regulation of CoA-transferase activity", "changes": { "is_a": { "current": [ "GO:0051348" ], "previous": [ "GO:0051348", "GO:1905918" ] } } }, { "id": 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{ "id": "GO:0005968", "name": "Rab-protein geranylgeranyltransferase complex", "changes": { "is_a": { "current": [ "GO:1990234" ], "previous": [ "GO:0032476" ] } } }, { "id": "GO:0009519", "name": "middle lamella", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } }, { "id": "GO:0033165", "name": "interphotoreceptor matrix", "changes": { "is_a": { "current": [ "GO:0062023", "GO:0140047" ], "previous": [ "GO:0062023" ] } } }, { "id": "GO:0035805", "name": "egg coat", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } }, { "id": "GO:0045025", "name": "mitochondrial degradosome", "changes": { "is_a": { "current": [ "GO:0098798", "GO:1905354" ], "previous": [ "GO:0000177", "GO:0098798" ] } } }, { "id": "GO:0060102", "name": "cuticular extracellular matrix", "changes": { "is_a": { "current": [ "GO:0062023", "GO:0140047" ], "previous": [ "GO:0062023" ] } } }, { "id": "GO:0062039", "name": "biofilm matrix", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } }, { "id": "GO:0062129", "name": "chitin-based extracellular matrix", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } }, { "id": "GO:0070505", "name": "pollen coat", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } }, { "id": "GO:0070645", "name": "Ubisch body", "changes": { "relationship": { "current": [ "part_of GO:0140047" ], "previous": [ "part_of GO:0031012" ] } } }, { "id": "GO:0099535", "name": "synapse-associated extracellular matrix", "changes": { "is_a": { "current": [ "GO:0062023", "GO:0140047" ], "previous": [ "GO:0062023" ] } } }, { "id": "GO:1990377", "name": "organomineral extracellular matrix", "changes": { "is_a": { "current": [ "GO:0140047" ], "previous": [ "GO:0031012" ] } } } ] } } }