# Group: paint - Dataset: paint_xenbase

## SUMMARY

This report generated on 2024-12-19

  * Associations: 57737
  * Lines in file (incl headers): 57781
  * Lines skipped: 38
## Header From Original Association File

> !gaf-version: 2.2  
> !Created on Thu Nov 21 14:20:13 2024.  
> !generated-by: PANTHER  
> !date-generated: 2024-11-21  
> !PANTHER version: v.19.0.  
> !GO version: 2024-11-03.  

## Contents

[gorule-0000002](#gorule-0000002)

[gorule-0000005](#gorule-0000005)

[gorule-0000006](#gorule-0000006)

[gorule-0000007](#gorule-0000007)

[gorule-0000008](#gorule-0000008)

[gorule-0000011](#gorule-0000011)

[gorule-0000013](#gorule-0000013)

[gorule-0000015](#gorule-0000015)

[gorule-0000016](#gorule-0000016)

[gorule-0000017](#gorule-0000017)

[gorule-0000018](#gorule-0000018)

[gorule-0000020](#gorule-0000020)

[gorule-0000022](#gorule-0000022)

[gorule-0000027](#gorule-0000027)

[gorule-0000028](#gorule-0000028)

[gorule-0000029](#gorule-0000029)

[gorule-0000030](#gorule-0000030)

[gorule-0000037](#gorule-0000037)

[gorule-0000039](#gorule-0000039)

[gorule-0000042](#gorule-0000042)

[gorule-0000043](#gorule-0000043)

[gorule-0000046](#gorule-0000046)

[gorule-0000050](#gorule-0000050)

[gorule-0000055](#gorule-0000055)

[gorule-0000058](#gorule-0000058)

[gorule-0000061](#gorule-0000061)

[gorule-0000063](#gorule-0000063)

[gorule-0000064](#gorule-0000064)

[gorule-0000065](#gorule-0000065)

[other](#other)


## MESSAGES

### gorule-0000002

No 'NOT' annotations to binding ; GO:0005488 or 'protein binding ; GO:0005515'

* total: 0
### gorule-0000005

IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to to 'protein binding ; GO:0005515 or GO:0005488 binding''

* total: 0
### gorule-0000006

IEP and HEP usage is restricted to terms from the Biological Process ontology, except when assigned by GOC

* total: 0
### gorule-0000007

IPI should not be used with GO:0003824 catalytic activity or descendents

* total: 0
### gorule-0000008

No annotations should be made to uninformative high level terms

* total: 0
### gorule-0000011

ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND

* total: 0
### gorule-0000013

Taxon-appropriate annotation check

* total: 25
#### Messages
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A8J1JSW0	psap	involved_in	GO:0060742	GO_REF:0000033	IBA	PANTHER:PTN008518954|MGI:MGI:97783	P	Prosaposin isoform X1	UniProtKB:A0A8J1JSW0|PTN008970913	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-942249	hpgd	involved_in	GO:0007565	GO_REF:0000033	IBA	PANTHER:PTN008688435|UniProtKB:P15428|RGD:620087	P	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	UniProtKB:Q66JL5|PTN009175081	protein	taxon:8364	20170620	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-487098	gsk3b	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN002780427|RGD:70982|MGI:MGI:1861437|UniProtKB:P49841	F	[tau protein] kinase	UniProtKB:A0A8J0T0Z2|PTN008603401	protein	taxon:8364	20190426	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-478656	ankrd6	is_active_in	GO:0009707	GO_REF:0000033	IBA	PANTHER:PTN002794166|TAIR:locus:2117607	C	Ankrd6 protein	UniProtKB:A8WGD6|PTN008608620	protein	taxon:8364	20240206	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	F6XC23	LOC100485259	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	NUAK family SNF1-like kinase 1	UniProtKB:F6XC23|PTN008613909	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-6042192	sik3	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	non-specific serine_threonine protein kinase	UniProtKB:A0A6I8SYZ1|PTN000764592	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-5857794	nuak2	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	LOC100158605 protein	UniProtKB:B2GUK7|PTN008613910	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A8J1JSW0	psap	involved_in	GO:0060736	GO_REF:0000033	IBA	PANTHER:PTN008518954|MGI:MGI:97783	P	Prosaposin isoform X1	UniProtKB:A0A8J1JSW0|PTN008970913	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-980289	nuak1	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	NUAK family SNF1-like kinase 1	UniProtKB:F7B8H1|PTN008613908	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A8J1IVX3	LOC101732858	enables	GO:0047952	GO_REF:0000033	IBA	PANTHER:PTN000919759|MGI:MGI:95679|UniProtKB:C8VTT9|SGD:S000005420|SGD:S000002180	F	Glycerol-3-phosphate dehydrogenase [NAD(+)]	UniProtKB:A0A8J1IVX3|PTN008525401	protein	taxon:8364	20241120	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-484840	oxtr	involved_in	GO:0007565	GO_REF:0000033	IBA	PANTHER:PTN002797428|RGD:3239	P	Oxytocin receptor	UniProtKB:F7C7K9|PTN008610350	protein	taxon:8364	20200330	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A8J0QTA5	rag1	involved_in	GO:0002331	GO_REF:0000033	IBA	PANTHER:PTN002610391|MGI:MGI:97848	P	V(D)J recombination-activating protein 1	UniProtKB:A0A8J0QTA5|PTN008520087	protein	taxon:8364	20190208	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A803JZ84	LOC116412012	is_active_in	GO:0097208	GO_REF:0000033	IBA	PANTHER:PTN000849151|RGD:3666	C	Pulmonary surfactant-associated protein C	UniProtKB:A0A803JZ84|PTN008506476	protein	taxon:8364	20200205	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-482203	tnfrsf11a	involved_in	GO:0048535	GO_REF:0000033	IBA	PANTHER:PTN002932239|MGI:MGI:1314891	P	Tumor necrosis factor receptor superfamily member 11A	UniProtKB:F7DPT4|PTN002932244	protein	taxon:8364	20200211	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-867495	mark3	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	non-specific serine_threonine protein kinase	UniProtKB:A0A6I8QCB9|PTN008613942	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-952802	mettl16	enables	GO:0052907	GO_REF:0000033	IBA	PANTHER:PTN000333539|UniProtKB:P75782	F	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase	UniProtKB:B3DL09|PTN008548662	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-876451	mark2	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	non-specific serine_threonine protein kinase	UniProtKB:A0A6I8S976|PTN008613911	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-852771	sftpc	is_active_in	GO:0097208	GO_REF:0000033	IBA	PANTHER:PTN000849151|RGD:3666	C	Pulmonary surfactant-associated protein C	UniProtKB:A0A6I8PPP7|PTN000849152	protein	taxon:8364	20200205	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-1003323	gpd1	enables	GO:0047952	GO_REF:0000033	IBA	PANTHER:PTN000919759|MGI:MGI:95679|UniProtKB:C8VTT9|SGD:S000005420|SGD:S000002180	F	Glycerol-3-phosphate dehydrogenase [NAD(+)]	UniProtKB:Q6DFQ1|PTN000198066	protein	taxon:8364	20241120	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-6042140	mark4	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	MAP_microtubule affinity-regulating kinase 4 isoform X1	UniProtKB:A0A8J0SLL0|PTN008613876	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-950070	sik2	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	non-specific serine_threonine protein kinase	UniProtKB:A0A6I8SYG1|PTN008613888	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `UniProtKB	A0A8J1J5I8	sik1	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	non-specific serine_threonine protein kinase	UniProtKB:A0A8J1J5I8|PTN009091872	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-982757	nim1k	enables	GO:0050321	GO_REF:0000033	IBA	PANTHER:PTN000680111|UniProtKB:P27448|FB:FBgn0260934|UniProtKB:Q7KZI7|RGD:708483|UniProtKB:Q96L34	F	NIM1 serine_threonine protein kinase	UniProtKB:A0A803JF63|PTN008613892	protein	taxon:8364	20200809	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-490808	sftpb	is_active_in	GO:0097208	GO_REF:0000033	IBA	PANTHER:PTN008518949|RGD:621700	C	Pulmonary surfactant-associated protein B isoform X1	UniProtKB:A0A8J0QKX4|PTN008518953	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Violates GO Rule: GORULE:0000013: Taxon-appropriate annotation check -- `Xenbase	XB-GENE-5750870	wrap73	involved_in	GO:1990810	GO_REF:0000033	IBA	PANTHER:PTN000416664|PomBase:SPBC32H8.09	P	WD repeat domain 8	UniProtKB:Q28GI8|PTN008564007	protein	taxon:8364	20200319	GO_Central		
`
### gorule-0000015

Dual species taxon check

* total: 0
### gorule-0000016

With/From: IC annotations require a With/From GO ID

* total: 0
### gorule-0000017

IDA annotations must not have a With/From entry

* total: 0
### gorule-0000018

IPI annotations require a With/From entry

* total: 0
### gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 39
#### Messages
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0006266) -- `Xenbase	XB-GENE-1009779	lig1	involved_in	GO:0006266	GO_REF:0000033	IBA	PANTHER:PTN000048696|RGD:1309875|SGD:S000002323|UniProtKB:P49916	P	DNA ligase	UniProtKB:A0A8J0QYK6|PTN008694908	protein	taxon:8364	20241121	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0006288) -- `Xenbase	XB-GENE-5788004	lig3	involved_in	GO:0006288	GO_REF:0000033	IBA	PANTHER:PTN000825510|UniProtKB:P49916|RGD:1309875	P	DNA ligase	UniProtKB:F6WXI9|PTN008694900	protein	taxon:8364	20220517	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0032508) -- `Xenbase	XB-GENE-1007569	rad50	involved_in	GO:0032508	GO_REF:0000033	IBA	PANTHER:PTN000429848|UniProtKB:Q92878	P	DNA repair protein RAD50	UniProtKB:A0A8J0SAB8|PTN001051188	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0032508) -- `UniProtKB	A0A8J1IWY9	rtel1	involved_in	GO:0032508	GO_REF:0000033	IBA	PANTHER:PTN000158195|MGI:MGI:2139369	P	Regulator of telomere elongation helicase 1	UniProtKB:A0A8J1IWY9|PTN008518677	protein	taxon:8364	20200929	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0032508) -- `Xenbase	XB-GENE-969935	ddx11	involved_in	GO:0032508	GO_REF:0000033	IBA	PANTHER:PTN000158371|UniProtKB:Q96FC9	P	Probable ATP-dependent DNA helicase DDX11	UniProtKB:B5DEB4|PTN000895403	protein	taxon:8364	20200929	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0032508) -- `UniProtKB	A0A8J0R020	nbn	involved_in	GO:0032508	GO_REF:0000033	IBA	PANTHER:PTN000255549|UniProtKB:O60934	P	Nibrin	UniProtKB:A0A8J0R020|PTN008534084	protein	taxon:8364	20170228	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0042989) -- `Xenbase	XB-GENE-489056	twf1	involved_in	GO:0042989	GO_REF:0000033	IBA	PANTHER:PTN001011683|SGD:S000003312|MGI:MGI:1346078|MGI:MGI:1100520	P	Twinfilin-1	UniProtKB:Q5I082|PTN000349108	protein	taxon:8364	20170421	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0042989) -- `Xenbase	XB-GENE-953486	pfn4	involved_in	GO:0042989	GO_REF:0000033	IBA	PANTHER:PTN000176159|SGD:S000005648|UniProtKB:P35081|UniProtKB:O22655|UniProtKB:Q8I2J4|UniProtKB:Q9FR39	P	Profilin	UniProtKB:A0A6I8QTH5|PTN008325382	protein	taxon:8364	20230110	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0042989) -- `Xenbase	XB-GENE-6258559	tmsb4x	involved_in	GO:0042989	GO_REF:0000033	IBA	PANTHER:PTN002280337|MGI:MGI:3843061|UniProtKB:P62328|UniProtKB:P62326	P	Thymosin beta	UniProtKB:Q28EW7|PTN008532539	protein	taxon:8364	20221007	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0042989) -- `Xenbase	XB-GENE-5878659	twf2	involved_in	GO:0042989	GO_REF:0000033	IBA	PANTHER:PTN001011683|SGD:S000003312|MGI:MGI:1346078|MGI:MGI:1100520	P	Twf2 protein	UniProtKB:Q0VFJ9|PTN009012731	protein	taxon:8364	20170421	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0044806) -- `Xenbase	XB-GENE-982561	blm	involved_in	GO:0044806	GO_REF:0000033	IBA	PANTHER:PTN002672422|MGI:MGI:1328362|UniProtKB:P54132	P	DNA helicase	UniProtKB:F6THN7|PTN000345029	protein	taxon:8364	20190319	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0044806) -- `UniProtKB	A0A8J1JQP3	wrn	involved_in	GO:0044806	GO_REF:0000033	IBA	PANTHER:PTN002492232|UniProtKB:Q14191|MGI:MGI:109635	P	DNA helicase	UniProtKB:A0A8J1JQP3|PTN008550735	protein	taxon:8364	20190113	GO_Central		
`
* ERROR - Obsolete class with no replacement: Violates GORULE:0000020 (GO:0051103) -- `Xenbase	XB-GENE-943956	xrcc4	involved_in	GO:0051103	GO_REF:0000033	IBA	PANTHER:PTN002004633|UniProtKB:Q13426	P	DNA repair protein XRCC4	UniProtKB:A8WH10|PTN002004673	protein	taxon:8364	20190520	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-999974	mcm2	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000179907|UniProtKB:Q2R482|MGI:MGI:105380|UniProtKB:P49736	P	DNA replication licensing factor mcm2	UniProtKB:Q6DIH3|PTN000179936	protein	taxon:8364	20211215	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `UniProtKB	A0A803JMM0	recql5	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000344874|SGD:S000004802	P	DNA helicase	UniProtKB:A0A803JMM0|PTN001009476	protein	taxon:8364	20190319	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `UniProtKB	A0A8J1J4U7	recql4	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000344874|SGD:S000004802	P	ATP-dependent DNA helicase Q4 isoform X1	UniProtKB:A0A8J1J4U7|PTN000345147	protein	taxon:8364	20190319	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-5946446	mcm7	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000180038|MGI:MGI:1298398|UniProtKB:P33993|SGD:S000000406	P	DNA replication licensing factor mcm7	UniProtKB:Q6NX31|PTN001701201	protein	taxon:8364	20211215	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `UniProtKB	A0A8J1JQP3	wrn	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000344874|SGD:S000004802	P	DNA helicase	UniProtKB:A0A8J1JQP3|PTN008550735	protein	taxon:8364	20190319	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-1017313	recql	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000344874|SGD:S000004802	P	ATP-dependent DNA helicase	UniProtKB:A0A6I8SNZ1|PTN000344903	protein	taxon:8364	20190319	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-962678	zmcm6	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000180096|MGI:MGI:1298227|UniProtKB:Q14566|SGD:S000003169	P	Zygotic DNA replication licensing factor mcm6	UniProtKB:Q6P1V8|PTN001701224	protein	taxon:8364	20211215	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-5870537	mmcm6	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000180096|MGI:MGI:1298227|UniProtKB:Q14566|SGD:S000003169	P	Maternal DNA replication licensing factor mcm6	UniProtKB:Q28CM3|PTN000180124	protein	taxon:8364	20211215	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-1011481	mcm4	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000179968|SGD:S000006223|UniProtKB:P33991|MGI:MGI:103199	P	DNA replication licensing factor mcm4	UniProtKB:Q6GL41|PTN000179998	protein	taxon:8364	20211215	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-982561	blm	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000344874|SGD:S000004802	P	DNA helicase	UniProtKB:F6THN7|PTN000345029	protein	taxon:8364	20190319	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006268) -- `Xenbase	XB-GENE-979709	ssbp1	involved_in	GO:0006268	GO_REF:0000033	IBA	PANTHER:PTN000033807|FB:FBgn0010438|UniProtKB:Q04837	P	Single-stranded DNA-binding protein 1, mitochondrial	UniProtKB:Q08D46|PTN008497313	protein	taxon:8364	20240820	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006977) -- `Xenbase	XB-GENE-483731	cradd.1	involved_in	GO:0006977	GO_REF:0000033	IBA	PANTHER:PTN008354075|UniProtKB:P78560	P	CASP2 and RIPK1 domain containing adaptor with death domain	UniProtKB:Q6DJ38|PTN000385770	protein	taxon:8364	20240924	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0006978) -- `Xenbase	XB-GENE-487733	rps6ka6	involved_in	GO:0006978	GO_REF:0000033	IBA	PANTHER:PTN002806567|UniProtKB:Q9UK32	P	Ribosomal protein S6 kinase	UniProtKB:A0A6I8QSE5|PTN000682955	protein	taxon:8364	20200917	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `UniProtKB	A0A8J1JS80	zmiz1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000081664|UniProtKB:Q8NF64	F	Zinc finger MIZ domain-containing protein 1 isoform X1	UniProtKB:A0A8J1JS80|PTN008505790	protein	taxon:8364	20190426	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-982450	ncoa6	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000403110|UniProtKB:Q14686	F	Nuclear receptor coactivator 6	UniProtKB:F6XUT9|PTN008560896	protein	taxon:8364	20170228	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `UniProtKB	A0A6I8RN86	pprc1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000399017|UniProtKB:Q86YN6|UniProtKB:Q9UBK2	F	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1	UniProtKB:A0A6I8RN86|PTN008355935	protein	taxon:8364	20170228	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-1021737	zmiz1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000081664|UniProtKB:Q8NF64	F	Protein FAM3C	UniProtKB:B4F6V9|PTN009019947	protein	taxon:8364	20190426	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-1004403	ppargc1b	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000399017|UniProtKB:Q86YN6|UniProtKB:Q9UBK2	F	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	UniProtKB:A0A6I8Q4X1|PTN008560121	protein	taxon:8364	20170228	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-973224	sfr1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN002008993|UniProtKB:Q86XK3	F	Swi5-dependent recombination DNA repair protein 1 homolog	UniProtKB:F6YR00|PTN008623602	protein	taxon:8364	20171117	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-5738809	dcaf6	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000400123|UniProtKB:Q58WW2	F	DDB1 and CUL4-associated factor 6	UniProtKB:A0A803KKA4|PTN008560338	protein	taxon:8364	20190726	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-494718	ppargc1a	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000399017|UniProtKB:Q86YN6|UniProtKB:Q9UBK2	F	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	UniProtKB:A0A6I8QIY8|PTN000399074	protein	taxon:8364	20170228	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `UniProtKB	A0A8J1JBA2	zmiz2	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000081664|UniProtKB:Q8NF64	F	Zinc finger MIZ domain-containing protein 2 isoform X1	UniProtKB:A0A8J1JBA2|PTN008505788	protein	taxon:8364	20190426	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-486618	ncoa3	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000074430|UniProtKB:Q15788|RGD:620109|FB:FBgn0041092|MGI:MGI:1276535|UniProtKB:Q9Y6Q9|UniProtKB:Q15596|MGI:MGI:1276533	F	Nuclear receptor coactivator	UniProtKB:A0A6I8SM47|PTN008504149	protein	taxon:8364	20241119	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `UniProtKB	A0A8J1JJX9	ncoa1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN000074430|UniProtKB:Q15788|RGD:620109|FB:FBgn0041092|MGI:MGI:1276535|UniProtKB:Q9Y6Q9|UniProtKB:Q15596|MGI:MGI:1276533	F	Nuclear receptor coactivator	UniProtKB:A0A8J1JJX9|PTN008504155	protein	taxon:8364	20241119	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `UniProtKB	A0A8J1JMM2	ncoa7	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN002763768|UniProtKB:Q8NI08	F	Nuclear receptor coactivator 7 isoform X1	UniProtKB:A0A8J1JMM2|PTN008387516	protein	taxon:8364	20200203	GO_Central		
`
* WARNING - Obsolete class: Violates GORULE:0000020, but was repaired (GO:0030374) -- `Xenbase	XB-GENE-994039	sra1	enables	GO:0030374	GO_REF:0000033	IBA	PANTHER:PTN001050482|RGD:621148	F	LOC100135196 protein	UniProtKB:A9ULF3|PTN008565858	protein	taxon:8364	20241120	GO_Central		
`
### gorule-0000022

Check for, and filter, annotations made to retracted publications

* total: 0
### gorule-0000027

Each identifier in GAF is valid

* total: 6
#### Messages
* WARNING - Invalid identifier: GORULE:0000027: 15003269 does not match any id_syntax patterns for RGD in dbxrefs (RGD:15003269) -- `UniProtKB	A0A8J0SDK2	phka2	part_of	GO:0005964	GO_REF:0000033	IBA	PANTHER:PTN000844181|RGD:620186|RGD:15003269|RGD:621522	C	Phosphorylase b kinase regulatory subunit	UniProtKB:A0A8J0SDK2|PTN008952403	protein	taxon:8364	20240918	GO_Central		
`
* WARNING - Invalid identifier: GORULE:0000027: 41131609 does not match any id_syntax patterns for RGD in dbxrefs (RGD:41131609) -- `Xenbase	XB-GENE-968629	amy2a	enables	GO:0004556	GO_REF:0000033	IBA	PANTHER:PTN008108699|RGD:1593187|FB:FBgn0020506|UniProtKB:P04746|UniProtKB:P0DUB6|UniProtKB:P0DTE7|FB:FBgn0000079|UniProtKB:P0DTE8|RGD:41131609	F	Alpha-amylase	UniProtKB:F6QEY0|PTN000039917	protein	taxon:8364	20240920	GO_Central		
`
* WARNING - Invalid identifier: GORULE:0000027: 15003269 does not match any id_syntax patterns for RGD in dbxrefs (RGD:15003269) -- `Xenbase	XB-GENE-1010420	phkb	part_of	GO:0005964	GO_REF:0000033	IBA	PANTHER:PTN000844181|RGD:620186|RGD:15003269|RGD:621522	C	Phosphorylase b kinase regulatory subunit	UniProtKB:A0A6I8Q841|PTN008505083	protein	taxon:8364	20240918	GO_Central		
`
* WARNING - Invalid identifier: GORULE:0000027: 15003269 does not match any id_syntax patterns for RGD in dbxrefs (RGD:15003269) -- `UniProtKB	A0A8J1IKZ1	phka1	part_of	GO:0005964	GO_REF:0000033	IBA	PANTHER:PTN000844181|RGD:620186|RGD:15003269|RGD:621522	C	Phosphorylase b kinase regulatory subunit	UniProtKB:A0A8J1IKZ1|PTN000079004	protein	taxon:8364	20240918	GO_Central		
`
* WARNING - Invalid identifier: GORULE:0000027: 41131609 does not match any id_syntax patterns for RGD in dbxrefs (RGD:41131609) -- `Xenbase	XB-GENE-5725537	amy2b	enables	GO:0004556	GO_REF:0000033	IBA	PANTHER:PTN008108699|RGD:1593187|FB:FBgn0020506|UniProtKB:P04746|UniProtKB:P0DUB6|UniProtKB:P0DTE7|FB:FBgn0000079|UniProtKB:P0DTE8|RGD:41131609	F	Alpha-amylase	UniProtKB:Q66KD1|PTN000039916	protein	taxon:8364	20240920	GO_Central		
`
* WARNING - Invalid identifier: GORULE:0000027: 15003269 does not match any id_syntax patterns for RGD in dbxrefs (RGD:15003269) -- `Xenbase	XB-GENE-1012252	phka1p1	part_of	GO:0005964	GO_REF:0000033	IBA	PANTHER:PTN000844181|RGD:620186|RGD:15003269|RGD:621522	C	Phosphorylase b kinase regulatory subunit	UniProtKB:F6WBB6|PTN008505088	protein	taxon:8364	20240918	GO_Central		
`
### gorule-0000028

GO aspect should match the term's namespace; otherwise it is repaired to the appropriate aspect

* total: 0
### gorule-0000029

IEAs should be less than one year old.

* total: 0
### gorule-0000030

Obsolete GO_REFs are not allowed

* total: 0
### gorule-0000037

IBA annotations should ONLY be assigned_by GO_Central and have GO_REF:0000033 as a reference

* total: 0
### gorule-0000039

Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants

* total: 0
### gorule-0000042

Qualifier: IKR evidence code requires a NOT qualifier

* total: 0
### gorule-0000043

Check for valid combination of evidence code and GO_REF

* total: 0
### gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 16
#### Messages
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J1J0R2	tenm4	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000131466|MGI:MGI:1345184|MGI:MGI:2447063|MGI:MGI:1345185	F	Teneurin-4 isoform X1	UniProtKB:A0A8J1J0R2|PTN002257501	protein	taxon:8364	20200807	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-5799894	tenm2	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000131466|MGI:MGI:1345184|MGI:MGI:2447063|MGI:MGI:1345185	F	Teneurin-2 isoform X1	UniProtKB:A0A8J0SGK4|PTN008514713	protein	taxon:8364	20200807	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-947235	atl2	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	Atlastin-2 isoform X1	UniProtKB:A0A8J0R3R1|PTN000079194	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-976399	vps25	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000322234|UniProtKB:Q9BRG1	F	Vacuolar protein-sorting-associated protein 25	UniProtKB:F6T240|PTN008546329	protein	taxon:8364	20170228	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A6I8QJV4	tenm1	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000131466|MGI:MGI:1345184|MGI:MGI:2447063|MGI:MGI:1345185	F	Teneurin transmembrane protein 1	UniProtKB:A0A6I8QJV4|PTN000880700	protein	taxon:8364	20200807	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J1J5S3	pde2a	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000886790|UniProtKB:O00408|MGI:MGI:2446107	F	Phosphodiesterase	UniProtKB:A0A8J1J5S3|PTN008516312	protein	taxon:8364	20180916	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J1IUG0	LOC108648894	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	RING finger protein 112-like	UniProtKB:A0A8J1IUG0|PTN008952504	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-945669	atl1	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	Atlastin GTPase 1	UniProtKB:A0A6I8SRS4|PTN008505144	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J1J2N9	tenm3	enables	GO:0042803	GO_REF:0000033	IBA	PANTHER:PTN000131466|MGI:MGI:1345184|MGI:MGI:2447063|MGI:MGI:1345185	F	Teneurin-3 isoform X1	UniProtKB:A0A8J1J2N9|PTN002477328	protein	taxon:8364	20200807	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-5960850	rnf112.1	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	RING finger protein 112	UniProtKB:F7DSK6|PTN008505142	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-5995130	rnf112.2	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	RING finger protein 112-like	UniProtKB:A0A6I8RJS2|PTN008505139	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A803JUA3	LOC100496673	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	RING finger protein 112	UniProtKB:A0A803JUA3|PTN008505140	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J0SVJ0	rnf112	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	Ring finger protein 112 isoform X1	UniProtKB:A0A8J0SVJ0|PTN008952509	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A803JA20	gnmt	involved_in	GO:0051289	GO_REF:0000033	IBA	PANTHER:PTN001046627|RGD:2719|UniProtKB:Q14749|MGI:MGI:1202304	P	Glycine N-methyltransferase	UniProtKB:A0A803JA20|PTN008564631	protein	taxon:8364	20180916	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `UniProtKB	A0A8J1IXJ6	LOC116407644	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	RING finger protein 112-like	UniProtKB:A0A8J1IXJ6|PTN008952514	protein	taxon:8364	20190207	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms -- `Xenbase	XB-GENE-1009682	atl3	involved_in	GO:0051260	GO_REF:0000033	IBA	PANTHER:PTN000844237|FB:FBgn0039213|UniProtKB:Q8WXF7|UniProtKB:Q6DD88|UniProtKB:Q8NHH9	P	Atlastin GTPase 3	UniProtKB:A0A6I8PXX9|PTN008505146	protein	taxon:8364	20190207	GO_Central		
`
### gorule-0000050

Annotations to ISS, ISA and ISO should not be self-referential

* total: 0
### gorule-0000055

References should have only one ID per ID space

* total: 0
### gorule-0000058

Object extensions should conform to the extensions-patterns.yaml file in metadata

* total: 0
### gorule-0000061

Allowed gene product to term relations (gp2term)

* total: 0
### gorule-0000063

Annotations using ISS/ISA/ISO evidence should refer to a gene product (in the 'with' column)

* total: 0
### gorule-0000064

TreeGrafter IEAs should be filtered for GO reference species

* total: 0
### gorule-0000065

Annotations to term that are candidates for obsoletion should be removed

* total: 2
#### Messages
* WARNING - Violates GO Rule: GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed -- `Xenbase	XB-GENE-479918	il10	involved_in	GO:2000273	GO_REF:0000033	IBA	PANTHER:PTN009232391|UniProtKB:P22301	P	Interleukin family protein	UniProtKB:F7CQQ3|PTN009232548	protein	taxon:8364	20241010	GO_Central		
`
* WARNING - Violates GO Rule: GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed -- `UniProtKB	A0A8J0SD44	il20	involved_in	GO:2000273	GO_REF:0000033	IBA	PANTHER:PTN009232391|UniProtKB:P22301	P	Interleukin family protein	UniProtKB:A0A8J0SD44|PTN009232473	protein	taxon:8364	20241010	GO_Central		
`
### other

* total: 0