gocheck do not annotate.owl
type: Ontology
version IRI: gocheck do not annotate.owl
version info: 2026-06-08

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

created by
type: AnnotationProperty

creation date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

id
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

cell cycle checkpoint signaling
type: Class
subclass of: cellular process
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: part of
  some values from: regulation of biological process
subclass of: Restriction
  on property: part of
  some values from: cellular response to stimulus
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
subclass of: Restriction
  on property: regulates
  some values from: cell cycle
subclass of: Restriction
  on property: regulates
  some values from: cell cycle process
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle process
definition: A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
has_alternative_id: GO:0031576
has_alternative_id: GO:0071779
has_alternative_id: GO:0072395
has_alternative_id: GO:0072404
has_alternative_id: GO:0072407
database_cross_reference: Reactome:R-HSA-69620
database_cross_reference: Wikipedia:Cell_cycle_checkpoint
has_exact_synonym: cell cycle checkpoint
has_exact_synonym: signal transduction involved in G2/M transition checkpoint
has_exact_synonym: signal transduction involved in cell cycle checkpoint
has_narrow_synonym: G1/S checkpoint
has_narrow_synonym: G1/S transition checkpoint
has_narrow_synonym: G2/M checkpoint
has_narrow_synonym: G2/M transition checkpoint
has_obo_namespace: biological_process
id: GO:0000075
in_subset: gocheck do not annotate
comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here.

Axiom
annotated source: cell cycle checkpoint signaling
annotated property: definition
annotated target: A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
database_cross_reference: GOC:mtg_cell_cycle

Cell Cycle Checkpoints
type: Axiom
annotated source: cell cycle checkpoint signaling
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69620

mitotic G1 phase
type: Class
subclass of: G1 phase
subclass of: Restriction
  on property: part of
  some values from: mitotic interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
database_cross_reference: Reactome:R-HSA-69236
has_exact_synonym: G1 phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000080
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic G1 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
database_cross_reference: GOC:mtg_cell_cycle

G1 Phase
type: Axiom
annotated source: mitotic G1 phase
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69236

mitotic S phase
type: Class
subclass of: S phase
subclass of: Restriction
  on property: part of
  some values from: mitotic interphase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has_exact_synonym: S phase of mitotic cell cycle
has_exact_synonym: S-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000084
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic S phase
annotated property: definition
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic G2 phase
type: Class
subclass of: G2 phase
subclass of: Restriction
  on property: part of
  some values from: mitotic interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has_exact_synonym: G2 phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000085
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic G2 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
database_cross_reference: GOC:mtg_cell_cycle

mitotic M phase
type: Class
subclass of: M phase
subclass of: mitotic cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: Reactome:R-HSA-68886
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0000087
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

M Phase
type: Axiom
annotated source: mitotic M phase
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-68886

mitotic prophase
type: Class
subclass of: prophase
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0000088
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic prophase
annotated property: definition
annotated target: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

mitotic metaphase
type: Class
subclass of: metaphase
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
has_obo_namespace: biological_process
id: GO:0000089
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic metaphase
annotated property: definition
annotated target: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic anaphase
type: Class
subclass of: anaphase
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.
has_obo_namespace: biological_process
id: GO:0000090
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic anaphase
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

mitotic anaphase A
type: Class
subclass of: mitotic anaphase
definition: The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.
has_obo_namespace: biological_process
id: GO:0000091
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic anaphase A
annotated property: definition
annotated target: The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.
database_cross_reference: GOC:mtg_cell_cycle

mitotic anaphase B
type: Class
subclass of: mitotic anaphase
definition: The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.
has_obo_namespace: biological_process
id: GO:0000092
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic anaphase B
annotated property: definition
annotated target: The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.
database_cross_reference: GOC:mtg_cell_cycle

mitotic telophase
type: Class
subclass of: telophase
subclass of: Restriction
  on property: part of
  some values from: mitotic M phase
definition: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0000093
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic telophase
annotated property: definition
annotated target: The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

mitotic prometaphase
type: Class
subclass of: mitotic M phase
definition: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
term tracker item: https://github.com/geneontology/go-ontology/issues/24374
database_cross_reference: Reactome:R-HSA-68877
has_obo_namespace: biological_process
id: GO:0000236
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic prometaphase
annotated property: definition
annotated target: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
database_cross_reference: GOC:mtg_cell_cycle

Mitotic Prometaphase
type: Axiom
annotated source: mitotic prometaphase
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-68877

leptotene
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.
database_cross_reference: Wikipedia:Leptotene
database_cross_reference: Wikipedia:Meiosis#Leptotene
has_obo_namespace: biological_process
id: GO:0000237
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: leptotene
annotated property: definition
annotated target: The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.
database_cross_reference: GOC:mtg_cell_cycle

zygotene
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
database_cross_reference: Wikipedia:Meiosis#Zygotene
database_cross_reference: Wikipedia:Zygotene
has_obo_namespace: biological_process
id: GO:0000238
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: zygotene
annotated property: definition
annotated target: The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.
database_cross_reference: GOC:mtg_cell_cycle

pachytene
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
database_cross_reference: Wikipedia:Meiosis#Pachytene
database_cross_reference: Wikipedia:Pachytene
has_obo_namespace: biological_process
id: GO:0000239
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: pachytene
annotated property: definition
annotated target: The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.
database_cross_reference: GOC:mtg_cell_cycle

diplotene
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
database_cross_reference: Wikipedia:Diplotene
database_cross_reference: Wikipedia:Meiosis#Diplotene
has_obo_namespace: biological_process
id: GO:0000240
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: diplotene
annotated property: definition
annotated target: The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.
database_cross_reference: GOC:mtg_cell_cycle

diakinesis
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic prophase I
definition: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.
database_cross_reference: Wikipedia:Diakinesis
database_cross_reference: Wikipedia:Meiosis#Diakinesis
has_obo_namespace: biological_process
id: GO:0000241
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: diakinesis
annotated property: definition
annotated target: The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.
database_cross_reference: GOC:mtg_cell_cycle

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: Wikipedia:M_phase
has_exact_synonym: M-phase
has_obo_namespace: biological_process
id: GO:0000279
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: GOC:mtg_cell_cycle

cytokinesis
type: Class
subclass of: cell cycle process
subclass of: Restriction
  on property: has part
  some values from: cellular component organization
definition: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Wikipedia:Cytokinesis
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
has_obo_namespace: biological_process
id: GO:0000910
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.

Axiom
annotated source: cytokinesis
annotated property: definition
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
database_cross_reference: GOC:mtg_cell_cycle

Axiom
annotated source: cytokinesis
annotated property: has_exact_synonym
annotated target: cytokinesis involved in cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

response to acid chemical
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
has_broad_synonym: response to acid
has_obo_namespace: biological_process
has_related_synonym: response to acid anion
has_related_synonym: response to oxoanion
id: GO:0001101
in_subset: gocheck do not annotate
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.

Axiom
annotated source: response to acid chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
database_cross_reference: GOC:curators
database_cross_reference: GOC:rn

cilium or flagellum-dependent cell motility
type: Class
subclass of: cellular process
definition: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
has_exact_synonym: ciliary/flagellar motility
has_obo_namespace: biological_process
has_related_synonym: ciliary or bacterial-type flagellar motility
id: GO:0001539
in_subset: gocheck do not annotate
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.

Axiom
annotated source: cilium or flagellum-dependent cell motility
annotated property: definition
annotated target: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:hjd
database_cross_reference: GOC:krc

cytokine production
type: Class
subclass of: macromolecule biosynthetic process
subclass of: multicellular organismal process
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
term tracker item: https://github.com/geneontology/go-ontology/issues/19116
has_alternative_id: GO:0042032
has_alternative_id: GO:0042089
has_alternative_id: GO:0042107
has_alternative_id: GO:0050663
has_narrow_synonym: cytokine biosynthetic process
has_narrow_synonym: cytokine metabolic process
has_narrow_synonym: cytokine secretion
has_narrow_synonym: interferon production
has_narrow_synonym: interferon secretion
has_narrow_synonym: interleukin production
has_narrow_synonym: interleukin secretion
has_obo_namespace: biological_process
id: GO:0001816
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: cytokine production
annotated property: definition
annotated target: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

Axiom
annotated source: cytokine production
annotated property: has_narrow_synonym
annotated target: interferon production
database_cross_reference: GOC:add
database_cross_reference: GOC:mah

Axiom
annotated source: cytokine production
annotated property: has_narrow_synonym
annotated target: interferon secretion
database_cross_reference: GOC:add
database_cross_reference: GOC:mah

Axiom
annotated source: cytokine production
annotated property: has_narrow_synonym
annotated target: interleukin production
database_cross_reference: GOC:add
database_cross_reference: GOC:mah
database_cross_reference: http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F

Axiom
annotated source: cytokine production
annotated property: has_narrow_synonym
annotated target: interleukin secretion
database_cross_reference: GOC:add
database_cross_reference: GOC:mah
database_cross_reference: http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F

cytokine production involved in immune response
type: Class
subclass of: cytokine production
subclass of: production of molecular mediator of immune response
subclass of: Restriction
  on property: part of
  some values from: response to stimulus
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0002374
has_alternative_id: GO:0002375
has_narrow_synonym: cytokine biosynthetic process involved in immune response
has_obo_namespace: biological_process
has_related_synonym: cytokine production during immune response
has_related_synonym: cytokine secretion during immune response
has_related_synonym: cytokine secretion involved in immune response
id: GO:0002367
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: cytokine production involved in immune response
annotated property: definition
annotated target: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

Axiom
annotated source: cytokine production involved in immune response
annotated property: has_related_synonym
annotated target: cytokine production during immune response
database_cross_reference: GOC:dph

Axiom
annotated source: cytokine production involved in immune response
annotated property: has_related_synonym
annotated target: cytokine secretion during immune response
database_cross_reference: GOC:dph

B cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: response to stimulus
definition: Any process that contributes to cytokine production by a B cell.
has_exact_synonym: B lymphocyte cytokine production
has_exact_synonym: B-cell cytokine production
has_exact_synonym: B-lymphocyte cytokine production
has_obo_namespace: biological_process
id: GO:0002368
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: B cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a B cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

T cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: response to stimulus
definition: Any process that contributes to cytokine production by a T cell.
has_exact_synonym: T lymphocyte cytokine production
has_exact_synonym: T-cell cytokine production
has_exact_synonym: T-lymphocyte cytokine production
has_obo_namespace: biological_process
id: GO:0002369
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: T cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a T cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

natural killer cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
subclass of: response to external stimulus
subclass of: response to biotic stimulus
subclass of: biological process involved in interspecies interaction between organisms
definition: Any process that contributes to cytokine production by a natural killer cell.
has_exact_synonym: NK cell cytokine production
has_obo_namespace: biological_process
id: GO:0002370
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: natural killer cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a natural killer cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

dendritic cell cytokine production
type: Class
subclass of: cytokine production involved in immune response
definition: Any process that contributes to cytokine production by a dendritic cell.
has_obo_namespace: biological_process
id: GO:0002371
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: dendritic cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a dendritic cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

myeloid dendritic cell cytokine production
type: Class
subclass of: dendritic cell cytokine production
subclass of: myeloid leukocyte cytokine production
definition: Any process that contributes to cytokine production by a myeloid dendritic cell.
has_obo_namespace: biological_process
id: GO:0002372
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: myeloid dendritic cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a myeloid dendritic cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

plasmacytoid dendritic cell cytokine production
type: Class
subclass of: dendritic cell cytokine production
definition: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
has_obo_namespace: biological_process
id: GO:0002373
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: plasmacytoid dendritic cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

immunoglobulin production
type: Class
subclass of: production of molecular mediator of immune response
definition: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0002378
has_alternative_id: GO:0048305
has_exact_synonym: antibody production
has_narrow_synonym: immunoglobulin biosynthetic process
has_narrow_synonym: immunoglobulin secretion
has_obo_namespace: biological_process
id: GO:0002377
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: immunoglobulin production
annotated property: definition
annotated target: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

immunoglobulin production involved in immunoglobulin-mediated immune response
type: Class
subclass of: immunoglobulin production
subclass of: Restriction
  on property: part of
  some values from: response to stimulus
definition: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0002379
has_alternative_id: GO:0002380
has_exact_synonym: immunoglobulin production involved in immunoglobulin mediated immune response
has_narrow_synonym: immunoglobulin biosynthetic process involved in immune response
has_narrow_synonym: immunoglobulin secretion involved in immune response
has_obo_namespace: biological_process
has_related_synonym: antibody production during immune response
has_related_synonym: antibody secretion during immune response
has_related_synonym: immunoglobulin production during immune response
has_related_synonym: immunoglobulin production involved in immune response
id: GO:0002381
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: immunoglobulin production involved in immunoglobulin-mediated immune response
annotated property: definition
annotated target: The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:9185563

Axiom
annotated source: immunoglobulin production involved in immunoglobulin-mediated immune response
annotated property: has_related_synonym
annotated target: immunoglobulin production during immune response
database_cross_reference: GOC:dph

Axiom
annotated source: immunoglobulin production involved in immunoglobulin-mediated immune response
annotated property: has_related_synonym
annotated target: immunoglobulin production involved in immune response
database_cross_reference: GOC:dph

immunoglobulin production in mucosal tissue
type: Class
subclass of: immunoglobulin production involved in immunoglobulin-mediated immune response
definition: The synthesis and release of immunoglobulin in the mucosal tissue.
has_exact_synonym: antibody production in mucosal tissue
has_obo_namespace: biological_process
id: GO:0002426
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: immunoglobulin production in mucosal tissue
annotated property: definition
annotated target: The synthesis and release of immunoglobulin in the mucosal tissue.
database_cross_reference: GOC:jal

production of molecular mediator of immune response
type: Class
subclass of: macromolecule biosynthetic process
definition: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
has_obo_namespace: biological_process
has_related_synonym: production of cellular mediator of immune response
id: GO:0002440
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: production of molecular mediator of immune response
annotated property: definition
annotated target: The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022
database_cross_reference: ISBN:0781735149

cytokine production involved in inflammatory response
type: Class
subclass of: cytokine production
subclass of: Restriction
  on property: part of
  some values from: response to stimulus
definition: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
has_broad_synonym: cytokine production involved in acute inflammatory response
has_obo_namespace: biological_process
id: GO:0002534
in_subset: gocheck do not annotate

Axiom
annotated source: cytokine production involved in inflammatory response
annotated property: definition
annotated target: The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

antimicrobial peptide production
type: Class
subclass of: production of molecular mediator of immune response
subclass of: Restriction
  on property: part of
  some values from: response to external stimulus
subclass of: Restriction
  on property: part of
  some values from: response to biotic stimulus
subclass of: Restriction
  on property: part of
  some values from: biological process involved in interspecies interaction between organisms
definition: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
has_obo_namespace: biological_process
id: GO:0002775
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: antimicrobial peptide production
annotated property: definition
annotated target: The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:11807545
database_cross_reference: PMID:15638771

antibacterial peptide production
type: Class
subclass of: antimicrobial peptide production
definition: The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
has_obo_namespace: biological_process
id: GO:0002778
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: antibacterial peptide production
annotated property: definition
annotated target: The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:11807545
database_cross_reference: PMID:15638771

antifungal peptide production
type: Class
subclass of: antimicrobial peptide production
definition: The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
has_obo_namespace: biological_process
id: GO:0002781
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: antifungal peptide production
annotated property: definition
annotated target: The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:11807545
database_cross_reference: PMID:15638771

regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to biotic stimulus
definition: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
has_obo_namespace: biological_process
id: GO:0002831
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

negative regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to biotic stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to biotic stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: down regulation of response to biotic stimulus
has_exact_synonym: down-regulation of response to biotic stimulus
has_exact_synonym: downregulation of response to biotic stimulus
has_narrow_synonym: inhibition of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002832
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

positive regulation of response to biotic stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: response to biotic stimulus
subclass of: regulation of response to biotic stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to biotic stimulus
definition: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: up regulation of response to biotic stimulus
has_exact_synonym: up-regulation of response to biotic stimulus
has_exact_synonym: upregulation of response to biotic stimulus
has_narrow_synonym: activation of response to biotic stimulus
has_narrow_synonym: stimulation of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002833
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

isocitrate dehydrogenase [NAD(P)+] activity
type: Class
definition: Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.
term tracker item: https://github.com/geneontology/go-ontology/issues/23235
has_exact_synonym: isocitrate dehydrogenase activity
has_exact_synonym: isocitric acid dehydrogenase activity
has_exact_synonym: isocitric dehydrogenase activity
has_exact_synonym: oxalosuccinate carboxylase activity
has_exact_synonym: oxalosuccinate decarboxylase activity
has_exact_synonym: oxalosuccinic decarboxylase activity
has_obo_namespace: molecular_function
has_related_synonym: IDH activity
has_related_synonym: IDP activity
id: GO:0004448
in_subset: gocheck do not annotate

Axiom
annotated source: isocitrate dehydrogenase [NAD(P)+] activity
annotated property: definition
annotated target: Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.
database_cross_reference: GOC:curators

transporter activity
type: Class
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
term tracker item: https://github.com/geneontology/go-ontology/issues/27621
has_alternative_id: GO:0005478
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

taurine transmembrane transporter activity
type: Class
subclass of: transporter activity
subclass of: Restriction
  on property: part of
  some values from: transport
subclass of: Restriction
  on property: part of
  some values from: cellular process
definition: Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.
has_obo_namespace: molecular_function
id: GO:0005368
in_subset: gocheck do not annotate

Axiom
annotated source: taurine transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.
database_cross_reference: GOC:ai

cell wall
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: cellular anatomical structure
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/21669
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

intracellular anatomical structure
type: Class
subclass of: cellular anatomical structure
definition: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
term tracker item: https://github.com/geneontology/go-ontology/issues/17776
database_cross_reference: Wikipedia:Intracellular
has_exact_synonym: internal to cell
has_exact_synonym: intracellular
has_exact_synonym: protoplasm
has_obo_namespace: cellular_component
has_related_synonym: nucleocytoplasm
has_related_synonym: protoplast
id: GO:0005622
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim plant

Axiom
annotated source: intracellular anatomical structure
annotated property: definition
annotated target: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: intracellular anatomical structure
annotated property: has_related_synonym
annotated target: nucleocytoplasm
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular anatomical structure
annotated property: has_related_synonym
annotated target: protoplast
database_cross_reference: GOC:mah

alcohol metabolic process
type: Class
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
has_exact_synonym: alcohol metabolism
has_obo_namespace: biological_process
id: GO:0006066
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: alcohol metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
database_cross_reference: ISBN:0198506732

pyruvate metabolic process
type: Class
subclass of: carboxylic acid metabolic process
definition: The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
term tracker item: https://github.com/geneontology/go-ontology/issues/29541
term tracker item: https://github.com/geneontology/go-ontology/issues/31634
has_alternative_id: GO:0006087
database_cross_reference: Wikipedia:Pyruvic_acid
has_exact_synonym: pyruvate metabolism
has_obo_namespace: biological_process
has_related_synonym: pyruvate dehydrogenase bypass
id: GO:0006090
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: pyruvate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
database_cross_reference: GOC:curators

fermentation
type: Class
subclass of: metabolic process
definition: The metabolic process that uses oxidation-reduction reactions of organic compounds and substrate-level phosphorylation for the generation of adenosine triphosphate (ATP), without consuming oxygen and is independent of electron transport chains.
term tracker item: https://github.com/geneontology/go-ontology/issues/28523
term tracker item: https://github.com/geneontology/go-ontology/issues/29511
database_cross_reference: MetaCyc:Fermentation
database_cross_reference: Wikipedia:Fermentation_(biochemistry)
has_obo_namespace: biological_process
id: GO:0006113
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: PMID:38821505 mentions exceptions regarding organic compounds and electron transport chain. Fermentation sub-processes exclude glycolysis to prevent redundancy with the glycolytic pathway.

Axiom
annotated source: fermentation
annotated property: definition
annotated target: The metabolic process that uses oxidation-reduction reactions of organic compounds and substrate-level phosphorylation for the generation of adenosine triphosphate (ATP), without consuming oxygen and is independent of electron transport chains.
database_cross_reference: PMID:25617754
database_cross_reference: PMID:38821505

nucleobase-containing compound metabolic process
type: Class
subclass of: primary metabolic process
definition: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
has_alternative_id: GO:0055134
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0006139
in_subset: gocheck do not annotate
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:ai

Axiom
annotated source: nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

transport
type: Class
subclass of: establishment of localization
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/20292
created by: jl
creation date: 2012-12-13T16:25:32Z
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
has_alternative_id: GO:0044765
database_cross_reference: Reactome:R-HSA-382551
has_obo_namespace: biological_process
has_related_synonym: single-organism transport
id: GO:0006810
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.

Axiom
annotated source: transport
annotated property: definition
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
database_cross_reference: GOC:dos
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Transport of small molecules
type: Axiom
annotated source: transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382551

organelle organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
created by: jl
creation date: 2013-12-19T15:25:51Z
has_alternative_id: GO:1902589
database_cross_reference: Reactome:R-HSA-1852241
has_exact_synonym: organelle organisation
has_exact_synonym: single organism organelle organization
has_obo_namespace: biological_process
has_related_synonym: organelle organization and biogenesis
has_related_synonym: single-organism organelle organization
id: GO:0006996
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: organelle organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

Organelle biogenesis and maintenance
type: Axiom
annotated source: organelle organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1852241

Axiom
annotated source: organelle organization
annotated property: has_exact_synonym
annotated target: single organism organelle organization
database_cross_reference: GOC:TermGenie

Axiom
annotated source: organelle organization
annotated property: has_related_synonym
annotated target: organelle organization and biogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

cell cycle
type: Class
subclass of: cellular process
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Reactome:R-HSA-1640170
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:curators
database_cross_reference: GOC:mtg_cell_cycle

Cell Cycle
type: Axiom
annotated source: cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1640170

mitotic cell cycle checkpoint signaling
type: Class
subclass of: cell cycle checkpoint signaling
subclass of: mitotic cell cycle process
definition: A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
has_alternative_id: GO:0031575
has_alternative_id: GO:0071780
has_alternative_id: GO:0072413
has_alternative_id: GO:0072456
has_alternative_id: GO:0072474
has_exact_synonym: mitotic cell cycle checkpoint
has_exact_synonym: signal transduction involved in mitotic cell cycle checkpoint
has_narrow_synonym: signal transduction involved in mitotic G2/M transition checkpoint
has_narrow_synonym: signal transduction involved in mitotic cell cycle G1/S checkpoint
has_obo_namespace: biological_process
has_related_synonym: mitotic checkpoint
id: GO:0007093
in_subset: gocheck do not annotate

Axiom
annotated source: mitotic cell cycle checkpoint signaling
annotated property: definition
annotated target: A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
database_cross_reference: GOC:mtg_cell_cycle

meiotic prophase I
type: Class
subclass of: prophase
subclass of: meiosis I cell cycle phase
definition: The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0007128
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic prophase I
annotated property: definition
annotated target: The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

meiotic metaphase I
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: metaphase
subclass of: Restriction
  on property: part of
  some values from: meiotic M phase
definition: The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.
term tracker item: https://github.com/geneontology/go-ontology/issues/25408
has_obo_namespace: biological_process
id: GO:0007132
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic metaphase I
annotated property: definition
annotated target: The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.
database_cross_reference: GOC:mtg_cell_cycle

meiotic anaphase I
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: anaphase
subclass of: Restriction
  on property: part of
  some values from: meiotic M phase
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.
term tracker item: https://github.com/geneontology/go-ontology/issues/25408
has_obo_namespace: biological_process
id: GO:0007133
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic anaphase I
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.
database_cross_reference: GOC:mtg_cell_cycle

meiotic telophase I
type: Class
subclass of: telophase
subclass of: meiosis I cell cycle phase
definition: The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0007134
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic telophase I
annotated property: definition
annotated target: The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

meiotic prophase II
type: Class
subclass of: prophase
subclass of: meiosis II cell cycle phase
definition: The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
id: GO:0007136
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic prophase II
annotated property: definition
annotated target: The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

meiotic metaphase II
type: Class
subclass of: metaphase
subclass of: meiosis II cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic M phase
definition: The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.
term tracker item: https://github.com/geneontology/go-ontology/issues/25408
has_obo_namespace: biological_process
id: GO:0007137
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic metaphase II
annotated property: definition
annotated target: The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.
database_cross_reference: GOC:mtg_cell_cycle

meiotic anaphase II
type: Class
subclass of: meiosis II cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: anaphase
subclass of: Restriction
  on property: part of
  some values from: meiotic M phase
definition: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.
term tracker item: https://github.com/geneontology/go-ontology/issues/25408
has_obo_namespace: biological_process
id: GO:0007138
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic anaphase II
annotated property: definition
annotated target: The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.
database_cross_reference: GOC:mtg_cell_cycle

meiotic telophase II
type: Class
subclass of: telophase
subclass of: meiosis II cell cycle phase
definition: The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
has_obo_namespace: biological_process
id: GO:0007139
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic telophase II
annotated property: definition
annotated target: The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

multicellular organism development
type: Class
subclass of: multicellular organismal process
subclass of: anatomical structure development
definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
term tracker item: https://github.com/geneontology/go-ontology/issues/21234
has_obo_namespace: biological_process
id: GO:0007275
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim plant
comment: Note that this term was 'developmental process'.

Axiom
annotated source: multicellular organism development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

sex-chromosome dosage compensation
type: Class
subclass of: regulation of macromolecule biosynthetic process
subclass of: cellular component organization
definition: Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
term tracker item: https://github.com/geneontology/go-ontology/issues/25961
term tracker item: https://github.com/geneontology/go-ontology/issues/26961
has_broad_synonym: dosage compensation
database_cross_reference: Wikipedia:Sex-chromosome_dosage_compensation
has_exact_synonym: sex chromosome dosage compensation
has_obo_namespace: biological_process
id: GO:0007549
in_subset: gocheck do not annotate

Axiom
annotated source: sex-chromosome dosage compensation
annotated property: definition
annotated target: Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
database_cross_reference: GOC:ems
database_cross_reference: PMID:11498577
database_cross_reference: PMID:30049999
database_cross_reference: PMID:35306885

excretion
type: Class
subclass of: multicellular organismal process
definition: The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
term tracker item: https://github.com/geneontology/go-ontology/issues/22368
database_cross_reference: Wikipedia:Excretion
has_obo_namespace: biological_process
id: GO:0007588
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: excretion
annotated property: definition
annotated target: The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
database_cross_reference: ISBN:0192801023

behavior
type: Class
subclass of: multicellular organismal process
definition: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
created by: jl
creation date: 2012-09-20T14:06:08Z
has_alternative_id: GO:0023032
has_alternative_id: GO:0044708
has_alternative_id: GO:0044709
database_cross_reference: Wikipedia:Behavior
has_exact_synonym: behavioral response to stimulus
has_exact_synonym: behaviour
has_exact_synonym: behavioural response to stimulus
has_obo_namespace: biological_process
has_related_synonym: single-organism behavior
id: GO:0007610
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).

Axiom
annotated source: behavior
annotated property: definition
annotated target: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395448956
database_cross_reference: PMID:20160973

transcription factor binding
type: Class
definition: Binding to a transcription factor, a protein required to initiate or regulate transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/19354
has_exact_synonym: TF binding
has_obo_namespace: molecular_function
has_related_synonym: transcription regulator binding
id: GO:0008134
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.

Axiom
annotated source: transcription factor binding
annotated property: definition
annotated target: Binding to a transcription factor, a protein required to initiate or regulate transcription.
database_cross_reference: ISBN:0198506732

metabolic process
type: Class
subclass of: cellular process
disjoint with: biological phase
disjoint with: localization
definition: A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
created by: jl
creation date: 2012-10-17T15:46:40Z
has_alternative_id: GO:0044236
has_alternative_id: GO:0044710
database_cross_reference: Reactome:R-HSA-1430728
database_cross_reference: Wikipedia:Metabolism
has_exact_synonym: metabolism
has_obo_namespace: biological_process
id: GO:0008152
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote ribbon
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

Axiom
annotated source: metabolic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198547684

Metabolism
type: Axiom
annotated source: metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1430728

cell death
type: Class
subclass of: cellular process
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
term tracker item: https://github.com/geneontology/go-ontology/issues/24680
has_obo_namespace: biological_process
has_related_synonym: accidental cell death
has_related_synonym: necrosis
id: GO:0008219
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.

Axiom
annotated source: cell death
annotated property: definition
annotated target: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: PMID:25236395

RNA ligase activity
type: Class
definition: Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another.
term tracker item: https://github.com/geneontology/go-ontology/issues/27418
has_obo_namespace: molecular_function
id: GO:0008452
in_subset: gocheck do not annotate

Axiom
annotated source: RNA ligase activity
annotated property: definition
annotated target: Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another.
database_cross_reference: GOC:mah

ferredoxin-[NAD(P)H] reductase activity
type: Class
definition: Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/21649
term tracker item: https://github.com/geneontology/go-ontology/issues/29598
has_broad_synonym: ferredoxin reductase activity
has_obo_namespace: molecular_function
id: GO:0008937
in_subset: gocheck do not annotate

Axiom
annotated source: ferredoxin-[NAD(P)H] reductase activity
annotated property: definition
annotated target: Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.
database_cross_reference: GOC:curators

catabolic process
type: Class
subclass of: metabolic process
definition: A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/28921
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
term tracker item: https://github.com/geneontology/go-ontology/issues/29627
created by: jl
creation date: 2012-10-17T15:52:35Z
has_alternative_id: GO:0044243
has_alternative_id: GO:0044712
database_cross_reference: Wikipedia:Catabolism
has_exact_synonym: breakdown of chemical
has_exact_synonym: breakdown of molecule
has_exact_synonym: breakdown of substance
has_exact_synonym: catabolism
has_exact_synonym: cellular breakdown
has_exact_synonym: cellular catabolism
has_exact_synonym: cellular degradation
has_exact_synonym: degradation
has_obo_namespace: biological_process
id: GO:0009056
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: catabolic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: ISBN:0198547684

macromolecule catabolic process
type: Class
subclass of: catabolic process
subclass of: macromolecule metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_alternative_id: GO:0043285
has_alternative_id: GO:0044266
has_exact_synonym: biopolymer catabolic process
has_exact_synonym: macromolecule breakdown
has_exact_synonym: macromolecule catabolism
has_exact_synonym: macromolecule degradation
has_narrow_synonym: multicellular organismal macromolecule catabolic process
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecule catabolic process
has_related_synonym: cellular macromolecule catabolism
has_related_synonym: cellular macromolecule degradation
id: GO:0009057
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: macromolecule catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule catabolic process
annotated property: has_exact_synonym
annotated target: biopolymer catabolic process
database_cross_reference: GOC:mtg_chebi_dec09

biosynthetic process
type: Class
subclass of: metabolic process
definition: A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
created by: jl
creation date: 2012-10-17T15:52:18Z
has_alternative_id: GO:0044274
has_alternative_id: GO:0044711
has_broad_synonym: formation
database_cross_reference: Wikipedia:Anabolism
has_exact_synonym: anabolism
has_exact_synonym: biosynthesis
has_exact_synonym: synthesis
has_narrow_synonym: multicellular organismal biosynthetic process
has_obo_namespace: biological_process
has_related_synonym: single-organism biosynthetic process
id: GO:0009058
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: biosynthetic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198547684

macromolecule biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: macromolecule metabolic process
definition: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/15249
term tracker item: https://github.com/geneontology/go-ontology/issues/25418
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
has_alternative_id: GO:0043284
has_exact_synonym: biopolymer biosynthetic process
has_exact_synonym: macromolecule anabolism
has_exact_synonym: macromolecule biosynthesis
has_exact_synonym: macromolecule formation
has_exact_synonym: macromolecule synthesis
has_obo_namespace: biological_process
id: GO:0009059
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: macromolecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule biosynthetic process
annotated property: has_exact_synonym
annotated target: biopolymer biosynthetic process
database_cross_reference: GOC:mtg_chebi_dec09

response to external stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
has_exact_synonym: response to environmental stimulus
has_obo_namespace: biological_process
id: GO:0009605
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:hb

response to biotic stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
has_narrow_synonym: response to biotic stress
has_obo_namespace: biological_process
id: GO:0009607
in_subset: gocheck do not annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
database_cross_reference: GOC:hb

response to abiotic stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
term tracker item: https://github.com/geneontology/go-ontology/issues/16572
has_narrow_synonym: response to abiotic stress
has_obo_namespace: biological_process
id: GO:0009628
in_subset: gocheck do not annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to abiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
database_cross_reference: GOC:hb

response to endogenous stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
has_obo_namespace: biological_process
id: GO:0009719
in_subset: gocheck do not annotate
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to endogenous stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
database_cross_reference: GOC:sm

embryo development
type: Class
subclass of: multicellular organism development
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Reactome:R-HSA-5619507
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim plant

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

Activation of HOX genes during differentiation
type: Axiom
annotated source: embryo development
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5619507

regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: biosynthetic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: biosynthetic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
has_exact_synonym: regulation of anabolism
has_exact_synonym: regulation of biosynthesis
has_exact_synonym: regulation of formation
has_exact_synonym: regulation of synthesis
has_obo_namespace: biological_process
id: GO:0009889
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of biosynthetic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:curators

negative regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: negative regulation of metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: biosynthetic process
definition: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_exact_synonym: down regulation of biosynthetic process
has_exact_synonym: down-regulation of biosynthetic process
has_exact_synonym: downregulation of biosynthetic process
has_exact_synonym: negative regulation of anabolism
has_exact_synonym: negative regulation of biosynthesis
has_exact_synonym: negative regulation of formation
has_exact_synonym: negative regulation of synthesis
has_narrow_synonym: inhibition of biosynthetic process
has_obo_namespace: biological_process
id: GO:0009890
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of biosynthetic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:curators

positive regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: positive regulation of metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_exact_synonym: positive regulation of anabolism
has_exact_synonym: positive regulation of biosynthesis
has_exact_synonym: positive regulation of formation
has_exact_synonym: positive regulation of synthesis
has_exact_synonym: up regulation of biosynthetic process
has_exact_synonym: up-regulation of biosynthetic process
has_exact_synonym: upregulation of biosynthetic process
has_narrow_synonym: activation of biosynthetic process
has_narrow_synonym: stimulation of biosynthetic process
has_obo_namespace: biological_process
id: GO:0009891
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of biosynthetic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:curators

negative regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_alternative_id: GO:0044252
has_exact_synonym: down regulation of metabolic process
has_exact_synonym: down-regulation of metabolic process
has_exact_synonym: downregulation of metabolic process
has_exact_synonym: negative regulation of metabolism
has_exact_synonym: negative regulation of organismal metabolism
has_narrow_synonym: inhibition of metabolic process
has_narrow_synonym: inhibition of organismal metabolic process
has_narrow_synonym: negative regulation of multicellular organismal metabolic process
has_obo_namespace: biological_process
id: GO:0009892
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:curators

positive regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: metabolic process
subclass of: regulation of metabolic process
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: metabolic process
definition: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_alternative_id: GO:0044253
database_cross_reference: Reactome:R-HSA-163765
has_exact_synonym: positive regulation of metabolism
has_exact_synonym: up regulation of metabolic process
has_exact_synonym: up-regulation of metabolic process
has_exact_synonym: upregulation of metabolic process
has_narrow_synonym: activation of metabolic process
has_narrow_synonym: positive regulation of multicellular organismal metabolic process
has_narrow_synonym: positive regulation of organismal metabolism
has_narrow_synonym: stimulation of metabolic process
has_narrow_synonym: stimulation of organismal metabolic process
has_narrow_synonym: up-regulation of organismal metabolic process
has_obo_namespace: biological_process
id: GO:0009893
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:curators

ChREBP activates metabolic gene expression
type: Axiom
annotated source: positive regulation of metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163765

regulation of catabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: catabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: catabolic process
definition: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
has_exact_synonym: regulation of breakdown
has_exact_synonym: regulation of catabolism
has_exact_synonym: regulation of degradation
has_obo_namespace: biological_process
id: GO:0009894
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of catabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
database_cross_reference: GOC:curators

cellular process
type: Class
disjoint with: biological phase
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
created by: jl
creation date: 2012-12-11T16:56:55Z
has_alternative_id: GO:0008151
has_alternative_id: GO:0044763
has_alternative_id: GO:0050875
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular process
id: GO:0009987
in_subset: gocheck do not annotate
in_subset: goslim plant
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.

Axiom
annotated source: cellular process
annotated property: definition
annotated target: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:curators
database_cross_reference: GOC:isa_complete

regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: macromolecule biosynthetic process
definition: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/31483
has_obo_namespace: biological_process
id: GO:0010556
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: positive regulation of macromolecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule biosynthetic process
definition: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/31483
has_obo_namespace: biological_process
id: GO:0010557
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: negative regulation of macromolecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule biosynthetic process
definition: Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/30771
has_obo_namespace: biological_process
id: GO:0010558
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of macromolecule biosynthetic process
annotated property: definition
annotated target: Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: macromolecule metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: macromolecule metabolic process
definition: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_obo_namespace: biological_process
id: GO:0010604
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of macromolecule metabolic process
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: macromolecule metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: macromolecule metabolic process
definition: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_obo_namespace: biological_process
id: GO:0010605
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of macromolecule metabolic process
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: organelle organization
definition: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: positive regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: positive regulation of organelle organization and biogenesis
id: GO:0010638
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of organelle organization
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of organelle organization
annotated property: has_exact_synonym
annotated target: positive regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: positive regulation of organelle organization
annotated property: has_related_synonym
annotated target: positive regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

negative regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: organelle organization
subclass of: regulation of organelle organization
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: organelle organization
definition: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: negative regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: negative regulation of organelle organization and biogenesis
id: GO:0010639
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of organelle organization
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of organelle organization
annotated property: has_exact_synonym
annotated target: negative regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: negative regulation of organelle organization
annotated property: has_related_synonym
annotated target: negative regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

regulation of protein ADP-ribosylation
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
has_exact_synonym: regulation of protein amino acid ADP-ribosylation
has_obo_namespace: biological_process
id: GO:0010835
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of protein ADP-ribosylation
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of protein ADP-ribosylation
annotated property: has_exact_synonym
annotated target: regulation of protein amino acid ADP-ribosylation
database_cross_reference: GOC:bf

negative regulation of protein ADP-ribosylation
type: Class
subclass of: regulation of protein ADP-ribosylation
subclass of: negative regulation of molecular function
definition: Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
has_exact_synonym: negative regulation of protein amino acid ADP-ribosylation
has_obo_namespace: biological_process
id: GO:0010836
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of protein ADP-ribosylation
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of protein ADP-ribosylation
annotated property: has_exact_synonym
annotated target: negative regulation of protein amino acid ADP-ribosylation
database_cross_reference: GOC:bf

macrophage cytokine production
type: Class
subclass of: myeloid leukocyte cytokine production
definition: The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_obo_namespace: biological_process
id: GO:0010934
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: macrophage cytokine production
annotated property: definition
annotated target: The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:dph
database_cross_reference: GOC:rl
database_cross_reference: GOC:tb

response to fluoxetine
type: Class
subclass of: response to antidepressant
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
has_obo_namespace: biological_process
has_related_synonym: response to SSRI
has_related_synonym: response to selective serotonin reuptake inhibitor
id: GO:0014076
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to fluoxetine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
database_cross_reference: GOC:ef
database_cross_reference: GOC:pr

cellular component organization
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
has_exact_synonym: cell organisation
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
has_obo_namespace: biological_process
has_related_synonym: cell organization and biogenesis
id: GO:0016043
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cellular component organization
annotated property: definition
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_exact_synonym
annotated target: cellular component organisation in other organism
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization
annotated property: has_related_synonym
annotated target: cell organization and biogenesis
database_cross_reference: GOC:mah

cell growth
type: Class
subclass of: cellular process
subclass of: growth
definition: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has_alternative_id: GO:0048591
has_exact_synonym: cellular growth
has_exact_synonym: growth of cell
has_obo_namespace: biological_process
has_related_synonym: cell expansion
has_related_synonym: metabolic process resulting in cell growth
has_related_synonym: metabolism resulting in cell growth
has_related_synonym: non-developmental cell growth
has_related_synonym: non-developmental growth of a unicellular organism
id: GO:0016049
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell growth
annotated property: definition
annotated target: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
database_cross_reference: GOC:ai

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental cell growth
database_cross_reference: GOC:mah

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental growth of a unicellular organism
database_cross_reference: GOC:mah

enoyl-[acyl-carrier-protein] reductase [NAD(P)H] activity
type: Class
definition: Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/25307
term tracker item: https://github.com/geneontology/go-ontology/issues/28526
has_broad_synonym: enoyl-[acyl-carrier-protein] reductase activity
database_cross_reference: Wikipedia:Enoyl-acyl_carrier_protein_reductase
has_exact_synonym: enoyl-ACP reductase activity
has_exact_synonym: enoyl-[acyl-carrier protein] reductase activity
has_exact_synonym: enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)
has_exact_synonym: enoyl-acyl carrier protein reductase
has_obo_namespace: molecular_function
id: GO:0016631
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation; please use of the children that specifies the cofactor of the reaction (NAD+ or NADP+): enoyl-[acyl-carrier-protein] reductase (NADH) activity ; GO:0004318 or enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148.

Axiom
annotated source: enoyl-[acyl-carrier-protein] reductase [NAD(P)H] activity
annotated property: definition
annotated target: Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+.
database_cross_reference: GOC:rb

peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
type: Class
subclass of: peptidyl-amino acid modification
definition: The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.
database_cross_reference: RESID:AA0031
has_exact_synonym: 2-pyrrolidone-5-carboxylic acid biosynthesis
has_exact_synonym: 2-pyrrolidone-5-carboxylic acid biosynthetic process
has_exact_synonym: peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase
has_exact_synonym: peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase
has_exact_synonym: peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase
has_obo_namespace: biological_process
id: GO:0017186
in_subset: gocheck do not annotate
comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'.

Axiom
annotated source: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.
database_cross_reference: RESID:AA0031

peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
type: Class
subclass of: peptidyl-amino acid modification
definition: The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid.
database_cross_reference: RESID:AA0128
has_exact_synonym: peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine
has_exact_synonym: peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine
has_exact_synonym: peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine
has_obo_namespace: biological_process
id: GO:0018061
in_subset: gocheck do not annotate

Axiom
annotated source: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
annotated property: definition
annotated target: The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid.
database_cross_reference: RESID:AA0128

peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
type: Class
subclass of: peptidyl-amino acid modification
definition: The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases.
database_cross_reference: RESID:AA0185
has_exact_synonym: peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine
has_exact_synonym: peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine
has_exact_synonym: peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine
has_obo_namespace: biological_process
id: GO:0018083
in_subset: gocheck do not annotate

Axiom
annotated source: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
annotated property: definition
annotated target: The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases.
database_cross_reference: RESID:AA0185

peptidyl-amino acid modification
type: Class
subclass of: protein modification process
definition: The alteration of an amino acid residue in a peptide.
has_obo_namespace: biological_process
id: GO:0018193
in_subset: gocheck do not annotate

Axiom
annotated source: peptidyl-amino acid modification
annotated property: definition
annotated target: The alteration of an amino acid residue in a peptide.
database_cross_reference: GOC:mah

peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
type: Class
subclass of: peptidyl-amino acid modification
definition: The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids.
database_cross_reference: RESID:AA0107
has_exact_synonym: peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine
has_exact_synonym: peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine
has_exact_synonym: peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine
has_obo_namespace: biological_process
id: GO:0018231
in_subset: gocheck do not annotate

Axiom
annotated source: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
annotated property: definition
annotated target: The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids.
database_cross_reference: RESID:AA0107

regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: regulation of primary metabolic process
subclass of: Restriction
  on property: regulates
  some values from: nucleobase-containing compound metabolic process
definition: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
has_exact_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_obo_namespace: biological_process
has_related_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0019219
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:curators

Axiom
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: metabolic process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
has_alternative_id: GO:0044246
database_cross_reference: Reactome:R-HSA-1989781
has_exact_synonym: regulation of metabolism
has_narrow_synonym: regulation of multicellular organismal metabolic process
has_narrow_synonym: regulation of organismal metabolic process
has_obo_namespace: biological_process
id: GO:0019222
in_subset: gocheck do not annotate
in_subset: goslim metagenomics

Axiom
annotated source: regulation of metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:curators

PPARA activates gene expression
type: Axiom
annotated source: regulation of metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1989781

Axiom
annotated source: regulation of metabolic process
annotated property: has_narrow_synonym
annotated target: regulation of organismal metabolic process
database_cross_reference: GOC:tb

protein metabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: primary metabolic process
definition: The chemical reactions and pathways involving a protein. Includes protein modification.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
has_alternative_id: GO:0006411
has_alternative_id: GO:0044267
has_alternative_id: GO:0044268
database_cross_reference: Reactome:R-HSA-392499
database_cross_reference: Wikipedia:Protein_metabolism
has_exact_synonym: cellular protein metabolic process
has_exact_synonym: cellular protein metabolism
has_exact_synonym: protein metabolic process and modification
has_exact_synonym: protein metabolism
has_exact_synonym: protein metabolism and modification
has_narrow_synonym: multicellular organismal protein metabolic process
has_obo_namespace: biological_process
id: GO:0019538
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: protein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a protein. Includes protein modification.
database_cross_reference: GOC:ma

Metabolism of proteins
type: Axiom
annotated source: protein metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392499

carboxylic acid metabolic process
type: Class
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
term tracker item: https://github.com/geneontology/go-ontology/issues/31063
database_cross_reference: Reactome:R-HSA-389661
has_exact_synonym: carboxylic acid metabolism
has_obo_namespace: biological_process
id: GO:0019752
in_subset: gocheck do not annotate

Axiom
annotated source: carboxylic acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
database_cross_reference: ISBN:0198506732

Glyoxylate metabolism and glycine degradation
type: Axiom
annotated source: carboxylic acid metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389661

sexual reproduction
type: Class
subclass of: reproductive process
definition: A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
term tracker item: https://github.com/geneontology/go-ontology/issues/22929
database_cross_reference: Wikipedia:Sexual_reproduction
has_obo_namespace: biological_process
id: GO:0019953
in_subset: gocheck do not annotate
comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.

Axiom
annotated source: sexual reproduction
annotated property: definition
annotated target: A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
database_cross_reference: Wikipedia:Sexual_reproduction

cell cycle process
type: Class
equivalent class: Class
  intersection of: cellular process
  intersection of: Restriction
    on property: part of
    some values from: cell cycle
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
has_obo_namespace: biological_process
id: GO:0022402
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon

Axiom
annotated source: cell cycle process
annotated property: definition
annotated target: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_cell_cycle

cell cycle phase
type: Class
subclass of: biological phase
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0022403
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:mtg_cell_cycle

cellular component disassembly
type: Class
subclass of: cellular component organization
disjoint with: cellular component assembly
definition: A cellular process that results in the breakdown of a cellular component.
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
has_alternative_id: GO:0071845
has_exact_synonym: cell structure disassembly
has_exact_synonym: cellular component disassembly at cellular level
has_obo_namespace: biological_process
id: GO:0022411
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular component disassembly
annotated property: definition
annotated target: A cellular process that results in the breakdown of a cellular component.
database_cross_reference: GOC:isa_complete

reproductive process in single-celled organism
type: Class
subclass of: reproductive process
definition: A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
has_obo_namespace: biological_process
id: GO:0022413
in_subset: gocheck do not annotate

Axiom
annotated source: reproductive process in single-celled organism
annotated property: definition
annotated target: A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism.
database_cross_reference: GOC:isa_complete

reproductive process
type: Class
disjoint with: biological phase
definition: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
created by: jl
creation date: 2012-09-19T15:56:06Z
has_alternative_id: GO:0019952
has_alternative_id: GO:0044702
has_alternative_id: GO:0050876
database_cross_reference: Wikipedia:Reproduction
has_obo_namespace: biological_process
has_related_synonym: single organism reproductive process
id: GO:0022414
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete

menstrual cycle phase
type: Class
subclass of: biological phase
definition: The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.
has_obo_namespace: biological_process
id: GO:0022601
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: menstrual cycle phase
annotated property: definition
annotated target: The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:jid

cellular component assembly
type: Class
subclass of: cellular component organization
subclass of: Restriction
  on property: part of
  some values from: cellular component biogenesis
definition: The aggregation, arrangement and bonding together of a cellular component.
has_alternative_id: GO:0071844
has_exact_synonym: cell structure assembly
has_exact_synonym: cellular component assembly at cellular level
has_obo_namespace: biological_process
id: GO:0022607
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim pir

Axiom
annotated source: cellular component assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a cellular component.
database_cross_reference: GOC:isa_complete

cell projection organization
type: Class
subclass of: cellular component organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
term tracker item: https://github.com/geneontology/go-ontology/issues/23013
term tracker item: https://github.com/geneontology/go-ontology/issues/26279
has_exact_synonym: cell projection organisation
has_obo_namespace: biological_process
has_related_synonym: cell projection organization and biogenesis
has_related_synonym: cell surface structure organization and biogenesis
id: GO:0030030
in_subset: gocheck do not annotate
in_subset: goslim prokaryote

Axiom
annotated source: cell projection organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: PMID:16318917

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell projection organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell projection organization
annotated property: has_related_synonym
annotated target: cell surface structure organization and biogenesis
database_cross_reference: GOC:mah

cell projection assembly
type: Class
subclass of: cellular component assembly
subclass of: cell projection organization
definition: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
term tracker item: https://github.com/geneontology/go-ontology/issues/23013
has_exact_synonym: formation of a cell surface projection
has_obo_namespace: biological_process
has_related_synonym: cell projection biogenesis
id: GO:0030031
in_subset: gocheck do not annotate

Axiom
annotated source: cell projection assembly
annotated property: definition
annotated target: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: PMID:18391171

Axiom
annotated source: cell projection assembly
annotated property: has_related_synonym
annotated target: cell projection biogenesis
database_cross_reference: GOC:mah

autophagy of peroxisome
type: Class
subclass of: catabolic process
subclass of: process utilizing autophagic mechanism
subclass of: Restriction
  on property: has part
  some values from: transport
subclass of: Restriction
  on property: has part
  some values from: cellular process
definition: The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.
term tracker item: https://github.com/geneontology/go-ontology/issues/25541
term tracker item: https://github.com/geneontology/go-ontology/issues/26190
term tracker item: https://github.com/geneontology/go-ontology/issues/28542
has_broad_synonym: peroxisome degradation
has_broad_synonym: peroxisome disassembly
has_obo_namespace: biological_process
has_related_synonym: pexophagy
id: GO:0030242
in_subset: gocheck do not annotate

Axiom
annotated source: autophagy of peroxisome
annotated property: definition
annotated target: The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.
database_cross_reference: GOC:autophagy
database_cross_reference: PMID:10547367
database_cross_reference: PMID:20083110

nucleocytoplasmic transport complex
type: Class
definition: Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.
has_narrow_synonym: nucleocytoplasmic shuttling complex
has_obo_namespace: cellular_component
id: GO:0031074
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: nucleocytoplasmic transport complex
annotated property: definition
annotated target: Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.
database_cross_reference: GOC:mah

organelle membrane
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: membrane-bounded organelle
definition: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
term tracker item: https://github.com/geneontology/go-ontology/issues/31446
database_cross_reference: NIF_Subcellular:sao830981606
has_obo_namespace: cellular_component
has_related_synonym: intracellular membrane
id: GO:0031090
in_subset: gocheck do not annotate

Axiom
annotated source: organelle membrane
annotated property: definition
annotated target: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

Axiom
annotated source: organelle membrane
annotated property: has_related_synonym
annotated target: intracellular membrane
database_cross_reference: NIF_Subcellular:sao830981606

spindle checkpoint signaling
type: Class
subclass of: cell cycle checkpoint signaling
definition: A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
has_alternative_id: GO:0072416
database_cross_reference: Wikipedia:Spindle_checkpoint
has_exact_synonym: signal transduction involved in spindle checkpoint
has_exact_synonym: spindle checkpoint
has_obo_namespace: biological_process
id: GO:0031577
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.

Axiom
annotated source: spindle checkpoint signaling
annotated property: definition
annotated target: A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.
database_cross_reference: GOC:mtg_cell_cycle

negative regulation of protein binding
type: Class
subclass of: regulation of protein binding
subclass of: negative regulation of binding
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
has_exact_synonym: down regulation of protein binding
has_exact_synonym: down-regulation of protein binding
has_exact_synonym: downregulation of protein binding
has_narrow_synonym: inhibition of protein binding
has_obo_namespace: biological_process
id: GO:0032091
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of protein binding
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
database_cross_reference: GOC:mah

positive regulation of protein binding
type: Class
subclass of: regulation of protein binding
subclass of: positive regulation of binding
definition: Any process that activates or increases the frequency, rate or extent of protein binding.
has_exact_synonym: up regulation of protein binding
has_exact_synonym: up-regulation of protein binding
has_exact_synonym: upregulation of protein binding
has_narrow_synonym: activation of protein binding
has_narrow_synonym: stimulation of protein binding
has_obo_namespace: biological_process
id: GO:0032092
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of protein binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of protein binding.
database_cross_reference: GOC:mah

regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: response to external stimulus
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to external stimulus
definition: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
has_obo_namespace: biological_process
id: GO:0032101
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to external stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

negative regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to external stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
has_exact_synonym: down regulation of response to external stimulus
has_exact_synonym: down-regulation of response to external stimulus
has_exact_synonym: downregulation of response to external stimulus
has_narrow_synonym: inhibition of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032102
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to external stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

positive regulation of response to external stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: response to external stimulus
subclass of: regulation of response to external stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to external stimulus
definition: Any process that activates, maintains or increases the rate of a response to an external stimulus.
has_exact_synonym: up regulation of response to external stimulus
has_exact_synonym: up-regulation of response to external stimulus
has_exact_synonym: upregulation of response to external stimulus
has_narrow_synonym: activation of response to external stimulus
has_narrow_synonym: stimulation of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032103
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to external stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to an external stimulus.
database_cross_reference: GOC:mah

regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: intracellular transport
subclass of: regulation of localization
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: intracellular transport
definition: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
has_obo_namespace: biological_process
id: GO:0032386
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of intracellular transport
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah

multicellular organismal process
type: Class
disjoint with: biological phase
definition: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
created by: jl
creation date: 2012-09-19T16:07:47Z
has_alternative_id: GO:0044707
has_alternative_id: GO:0050874
has_exact_synonym: organismal physiological process
has_obo_namespace: biological_process
has_related_synonym: single-multicellular organism process
id: GO:0032501
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: multicellular organismal process
annotated property: definition
annotated target: Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

connective tissue growth factor production
type: Class
subclass of: cytokine production
definition: The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_exact_synonym: CCN2 production
has_exact_synonym: CTGF production
has_exact_synonym: Fisp12 production
has_exact_synonym: Hcs24 production
has_exact_synonym: IGFBP8 production
has_exact_synonym: hypertrophic chondrocyte-specific gene product 24 production
has_obo_namespace: biological_process
id: GO:0032601
in_subset: gocheck do not annotate

Axiom
annotated source: connective tissue growth factor production
annotated property: definition
annotated target: The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

chemokine production
type: Class
subclass of: cytokine production
definition: The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
creation date: 2009-12-18T11:26:20Z
has_alternative_id: GO:0042033
has_alternative_id: GO:0050755
has_alternative_id: GO:0090195
has_exact_synonym: chemokine anabolism
has_exact_synonym: chemokine biosynthesis
has_exact_synonym: chemokine formation
has_exact_synonym: chemokine synthesis
has_narrow_synonym: chemokine biosynthetic process
has_narrow_synonym: chemokine metabolic process
has_narrow_synonym: chemokine secretion
has_obo_namespace: biological_process
id: GO:0032602
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine production
annotated property: definition
annotated target: The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:rl
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:12183377
database_cross_reference: Wikipedia:Chemokine

fractalkine production
type: Class
subclass of: chemokine production
definition: The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
term tracker item: https://github.com/geneontology/go-ontology/issues/19254
has_alternative_id: GO:0050751
has_alternative_id: GO:0050754
has_alternative_id: GO:0050756
has_exact_synonym: ABCD-3 production
has_exact_synonym: CX3CL1 production
has_exact_synonym: neurotactin production
has_narrow_synonym: fractalkine biosynthetic process
has_narrow_synonym: fractalkine metabolic process
has_obo_namespace: biological_process
id: GO:0032603
in_subset: gocheck do not annotate

Axiom
annotated source: fractalkine production
annotated property: definition
annotated target: The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:12729461

granulocyte macrophage colony-stimulating factor production
type: Class
subclass of: cytokine production
subclass of: protein metabolic process
definition: The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042253
has_exact_synonym: GM-CSF production
has_exact_synonym: granulocyte macrophage colony stimulating factor production
has_narrow_synonym: granulocyte macrophage colony-stimulating factor biosynthetic process
has_obo_namespace: biological_process
id: GO:0032604
in_subset: gocheck do not annotate

Axiom
annotated source: granulocyte macrophage colony-stimulating factor production
annotated property: definition
annotated target: The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

Axiom
annotated source: granulocyte macrophage colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: GM-CSF production
database_cross_reference: GOC:vk

hepatocyte growth factor production
type: Class
subclass of: cytokine production
subclass of: protein metabolic process
definition: The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0048175
has_exact_synonym: HGF production
has_exact_synonym: scatter factor production
has_narrow_synonym: hepatocyte growth factor biosynthetic process
has_obo_namespace: biological_process
id: GO:0032605
in_subset: gocheck do not annotate

Axiom
annotated source: hepatocyte growth factor production
annotated property: definition
annotated target: The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:1838014

type I interferon production
type: Class
subclass of: cytokine production
definition: The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
has_alternative_id: GO:0045351
has_alternative_id: GO:0072641
has_exact_synonym: interferon type I production
has_exact_synonym: type I IFN production
has_narrow_synonym: type I interferon biosynthetic process
has_narrow_synonym: type I interferon secretion
has_obo_namespace: biological_process
id: GO:0032606
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: type I interferon production
annotated property: definition
annotated target: The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0126896631
database_cross_reference: PMID:15546383
database_cross_reference: PMID:16681834

Axiom
annotated source: type I interferon production
annotated property: has_exact_synonym
annotated target: type I IFN production
database_cross_reference: GOC:mah

interferon-alpha production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045349
has_alternative_id: GO:0072642
has_exact_synonym: IFN-alpha production
has_exact_synonym: IFNA production
has_narrow_synonym: interferon-alpha biosynthetic process
has_narrow_synonym: interferon-alpha secretion
has_obo_namespace: biological_process
id: GO:0032607
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-alpha production
annotated property: definition
annotated target: The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-alpha production
annotated property: has_exact_synonym
annotated target: IFN-alpha production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-alpha production
annotated property: has_exact_synonym
annotated target: IFNA production
database_cross_reference: GOC:mah

interferon-beta production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0035546
has_alternative_id: GO:0045350
has_exact_synonym: IFN-beta production
has_exact_synonym: IFNB production
has_narrow_synonym: interferon-beta biosynthetic process
has_narrow_synonym: interferon-beta secretion
has_obo_namespace: biological_process
id: GO:0032608
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-beta production
annotated property: definition
annotated target: The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-beta production
annotated property: has_exact_synonym
annotated target: IFNB production
database_cross_reference: GOC:mah

type II interferon production
type: Class
subclass of: cytokine production
definition: The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
has_alternative_id: GO:0042095
has_alternative_id: GO:0072643
has_exact_synonym: IFNG production
has_exact_synonym: interferon-gamma production
has_exact_synonym: type II IFN production
has_narrow_synonym: interferon-gamma biosynthetic process
has_narrow_synonym: interferon-gamma secretion
has_obo_namespace: biological_process
id: GO:0032609
in_subset: gocheck do not annotate

Axiom
annotated source: type II interferon production
annotated property: definition
annotated target: The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
database_cross_reference: GOC:add
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: type II interferon production
annotated property: has_exact_synonym
annotated target: IFNG production
database_cross_reference: GOC:mah

Axiom
annotated source: type II interferon production
annotated property: has_exact_synonym
annotated target: type II IFN production
database_cross_reference: GOC:mah

interleukin-1 alpha production
type: Class
subclass of: interleukin-1 production
definition: The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0050703
has_alternative_id: GO:0050719
has_exact_synonym: IL-1 alpha production
has_narrow_synonym: interleukin-1 alpha biosynthetic process
has_narrow_synonym: interleukin-1 alpha secretion
has_obo_namespace: biological_process
id: GO:0032610
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-1 alpha production
annotated property: definition
annotated target: The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-1 beta production
type: Class
subclass of: interleukin-1 production
definition: The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0050702
has_alternative_id: GO:0050720
has_exact_synonym: IL-1 beta production
has_narrow_synonym: interleukin-1 beta biosynthetic process
has_narrow_synonym: interleukin-1 beta secretion
has_obo_namespace: biological_process
id: GO:0032611
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-1 beta production
annotated property: definition
annotated target: The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-1 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042222
has_alternative_id: GO:0050701
has_exact_synonym: IL-1 production
has_narrow_synonym: interleukin-1 biosynthetic process
has_narrow_synonym: interleukin-1 secretion
has_obo_namespace: biological_process
id: GO:0032612
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-1 production
annotated property: definition
annotated target: The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-10 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042091
has_alternative_id: GO:0072608
has_exact_synonym: IL-10 production
has_narrow_synonym: interleukin-10 biosynthetic process
has_narrow_synonym: interleukin-10 secretion
has_obo_namespace: biological_process
id: GO:0032613
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-10 production
annotated property: definition
annotated target: The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-11 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042230
has_alternative_id: GO:0072609
has_exact_synonym: IL-11 production
has_narrow_synonym: interleukin-11 biosynthetic process
has_narrow_synonym: interleukin-11 secretion
has_obo_namespace: biological_process
id: GO:0032614
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-11 production
annotated property: definition
annotated target: The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-12 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042090
has_alternative_id: GO:0072610
has_exact_synonym: IL-12 production
has_narrow_synonym: CLMF production
has_narrow_synonym: NKSF production
has_narrow_synonym: interleukin-12 biosynthetic process
has_narrow_synonym: interleukin-12 secretion
has_obo_namespace: biological_process
id: GO:0032615
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-12 production
annotated property: definition
annotated target: The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-12 production
annotated property: has_narrow_synonym
annotated target: CLMF production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-12 production
annotated property: has_narrow_synonym
annotated target: NKSF production
database_cross_reference: GOC:BHF

interleukin-13 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042231
has_alternative_id: GO:0072611
has_exact_synonym: IL-13 production
has_narrow_synonym: interleukin-13 biosynthetic process
has_narrow_synonym: interleukin-13 secretion
has_obo_namespace: biological_process
id: GO:0032616
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-13 production
annotated property: definition
annotated target: The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-15 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042233
has_alternative_id: GO:0072613
has_exact_synonym: IL-15 production
has_narrow_synonym: interleukin-15 biosynthetic process
has_narrow_synonym: interleukin-15 secretion
has_obo_namespace: biological_process
id: GO:0032618
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-15 production
annotated property: definition
annotated target: The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-16 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042234
has_alternative_id: GO:0072614
has_exact_synonym: IL-16 production
has_exact_synonym: pro-interleukin-16 production
has_narrow_synonym: LCF production
has_narrow_synonym: interleukin-16 biosynthetic process
has_narrow_synonym: interleukin-16 secretion
has_obo_namespace: biological_process
id: GO:0032619
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-16 production
annotated property: definition
annotated target: The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-16 production
annotated property: has_exact_synonym
annotated target: pro-interleukin-16 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-16 production
annotated property: has_narrow_synonym
annotated target: LCF production
database_cross_reference: GOC:BHF

interleukin-17 production
type: Class
subclass of: cytokine production
definition: The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042235
has_alternative_id: GO:0072615
has_exact_synonym: CTLA-8 production
has_exact_synonym: Cytotoxic T-lymphocyte-associated antigen 8 production
has_exact_synonym: IL-17 production
has_narrow_synonym: interleukin-17 biosynthetic process
has_narrow_synonym: interleukin-17 secretion
has_obo_namespace: biological_process
id: GO:0032620
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-17 production
annotated property: definition
annotated target: The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: GOC:rv
database_cross_reference: Wikipedia:Interleukin_17

Axiom
annotated source: interleukin-17 production
annotated property: has_exact_synonym
annotated target: CTLA-8 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-17 production
annotated property: has_exact_synonym
annotated target: Cytotoxic T-lymphocyte-associated antigen 8 production
database_cross_reference: GOC:BHF

interleukin-18 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042241
has_alternative_id: GO:0072616
has_exact_synonym: IGIF production
has_exact_synonym: IL-18 production
has_narrow_synonym: IL1F4 production
has_narrow_synonym: interleukin-18 biosynthetic process
has_narrow_synonym: interleukin-18 secretion
has_obo_namespace: biological_process
id: GO:0032621
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-18 production
annotated property: definition
annotated target: The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-18 production
annotated property: has_exact_synonym
annotated target: IGIF production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-18 production
annotated property: has_narrow_synonym
annotated target: IL1F4 production
database_cross_reference: GOC:BHF

interleukin-19 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042236
has_alternative_id: GO:0072617
has_exact_synonym: IL-19 production
has_narrow_synonym: IL-19 secretion
has_narrow_synonym: ZMDA1 secretion
has_narrow_synonym: interleukin-19 biosynthetic process
has_narrow_synonym: interleukin-19 secretion
has_obo_namespace: biological_process
id: GO:0032622
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-19 production
annotated property: definition
annotated target: The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-19 production
annotated property: has_narrow_synonym
annotated target: IL-19 secretion
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-19 production
annotated property: has_narrow_synonym
annotated target: ZMDA1 secretion
database_cross_reference: GOC:BHF

interleukin-2 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042094
has_alternative_id: GO:0070970
has_exact_synonym: IL-2 production
has_narrow_synonym: interleukin-2 biosynthetic process
has_narrow_synonym: interleukin-2 secretion
has_obo_namespace: biological_process
id: GO:0032623
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-2 production
annotated property: definition
annotated target: The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-20 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042237
has_alternative_id: GO:0072618
has_exact_synonym: IL-20 production
has_exact_synonym: ZCYTO10 production
has_narrow_synonym: interleukin-20 biosynthetic process
has_narrow_synonym: interleukin-20 secretion
has_obo_namespace: biological_process
id: GO:0032624
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-20 production
annotated property: definition
annotated target: The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-20 production
annotated property: has_exact_synonym
annotated target: ZCYTO10 production
database_cross_reference: GOC:BHF

interleukin-21 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042238
has_alternative_id: GO:0072619
has_exact_synonym: IL-21 production
has_narrow_synonym: interleukin-21 biosynthetic process
has_narrow_synonym: interleukin-21 secretion
has_obo_namespace: biological_process
id: GO:0032625
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-21 production
annotated property: definition
annotated target: The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-22 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042239
has_alternative_id: GO:0072620
has_exact_synonym: IL-22 production
has_exact_synonym: IL22 production
has_exact_synonym: ILTIF production
has_narrow_synonym: ZCYTO18 production
has_narrow_synonym: interleukin-22 biosynthetic process
has_narrow_synonym: interleukin-22 secretion
has_obo_namespace: biological_process
id: GO:0032626
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-22 production
annotated property: definition
annotated target: The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-22 production
annotated property: has_exact_synonym
annotated target: IL22 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-22 production
annotated property: has_exact_synonym
annotated target: ILTIF production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-22 production
annotated property: has_narrow_synonym
annotated target: ZCYTO18 production
database_cross_reference: GOC:BHF

interleukin-23 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042240
has_alternative_id: GO:0072621
has_exact_synonym: IL-23 production
has_narrow_synonym: interleukin-23 biosynthetic process
has_narrow_synonym: interleukin-23 secretion
has_obo_namespace: biological_process
id: GO:0032627
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-23 production
annotated property: definition
annotated target: The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-24 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045524
has_alternative_id: GO:0072622
has_exact_synonym: IL-24 production
has_narrow_synonym: MDA7 production
has_narrow_synonym: ST16 production
has_narrow_synonym: interleukin-24 biosynthetic process
has_narrow_synonym: interleukin-24 secretion
has_obo_namespace: biological_process
id: GO:0032628
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-24 production
annotated property: definition
annotated target: The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-24 production
annotated property: has_narrow_synonym
annotated target: MDA7 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-24 production
annotated property: has_narrow_synonym
annotated target: ST16 production
database_cross_reference: GOC:BHF

interleukin-25 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045525
has_alternative_id: GO:0072623
has_exact_synonym: IL-25 production
has_narrow_synonym: IL-25 secretion
has_narrow_synonym: IL17E secretion
has_narrow_synonym: interleukin-25 anabolism
has_narrow_synonym: interleukin-25 biosynthesis
has_narrow_synonym: interleukin-25 biosynthetic process
has_narrow_synonym: interleukin-25 formation
has_narrow_synonym: interleukin-25 secretion
has_narrow_synonym: interleukin-25 synthesis
has_obo_namespace: biological_process
id: GO:0032629
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-25 production
annotated property: definition
annotated target: The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-25 production
annotated property: has_narrow_synonym
annotated target: IL-25 secretion
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-25 production
annotated property: has_narrow_synonym
annotated target: IL17E secretion
database_cross_reference: GOC:BHF

interleukin-26 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045526
has_alternative_id: GO:0072624
has_exact_synonym: IL-26 production
has_narrow_synonym: AK155 secretion
has_narrow_synonym: interleukin-26 anabolism
has_narrow_synonym: interleukin-26 biosynthesis
has_narrow_synonym: interleukin-26 biosynthetic process
has_narrow_synonym: interleukin-26 formation
has_narrow_synonym: interleukin-26 secretion
has_narrow_synonym: interleukin-26 synthesis
has_obo_namespace: biological_process
id: GO:0032630
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-26 production
annotated property: definition
annotated target: The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-26 production
annotated property: has_narrow_synonym
annotated target: AK155 secretion
database_cross_reference: GOC:BHF

interleukin-27 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045527
has_alternative_id: GO:0072625
has_exact_synonym: IL-27 production
has_narrow_synonym: interleukin-27 biosynthetic process
has_narrow_synonym: interleukin-27 formation
has_narrow_synonym: interleukin-27 secretion
has_narrow_synonym: interleukin-27 synthesis
has_obo_namespace: biological_process
id: GO:0032631
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-27 production
annotated property: definition
annotated target: The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-3 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042223
has_alternative_id: GO:0072601
has_exact_synonym: IL-3 production
has_narrow_synonym: interleukin-3 biosynthetic process
has_narrow_synonym: interleukin-3 secretion
has_obo_namespace: biological_process
id: GO:0032632
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-3 production
annotated property: definition
annotated target: The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-4 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042097
has_alternative_id: GO:0042224
has_alternative_id: GO:0072602
has_exact_synonym: IL-4 production
has_narrow_synonym: interleukin-4 biosynthetic process
has_narrow_synonym: interleukin-4 secretion
has_obo_namespace: biological_process
id: GO:0032633
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-4 production
annotated property: definition
annotated target: The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-5 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042225
has_alternative_id: GO:0072603
has_exact_synonym: IL-5 production
has_narrow_synonym: interleukin-5 biosynthetic process
has_narrow_synonym: interleukin-5 secretion
has_obo_namespace: biological_process
id: GO:0032634
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-5 production
annotated property: definition
annotated target: The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-6 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042226
has_alternative_id: GO:0072604
has_exact_synonym: IL-6 production
has_narrow_synonym: interleukin-6 biosynthetic process
has_narrow_synonym: interleukin-6 secretion
has_obo_namespace: biological_process
id: GO:0032635
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-6 production
annotated property: definition
annotated target: The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-7 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042227
has_alternative_id: GO:0072605
has_exact_synonym: IL-7 production
has_narrow_synonym: interleukin-7 biosynthetic process
has_narrow_synonym: interleukin-7 secretion
has_obo_namespace: biological_process
id: GO:0032636
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-7 production
annotated property: definition
annotated target: The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-8 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042228
has_alternative_id: GO:0072606
has_exact_synonym: IL-8 production
has_narrow_synonym: interleukin-8 biosynthetic process
has_narrow_synonym: interleukin-8 secretion
has_obo_namespace: biological_process
id: GO:0032637
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-8 production
annotated property: definition
annotated target: The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

interleukin-9 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0042229
has_alternative_id: GO:0072607
has_exact_synonym: IL-9 production
has_narrow_synonym: interleukin-9 biosynthetic process
has_narrow_synonym: interleukin-9 secretion
has_obo_namespace: biological_process
id: GO:0032638
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-9 production
annotated property: definition
annotated target: The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

TRAIL production
type: Class
subclass of: tumor necrosis factor superfamily cytokine production
definition: The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0045553
has_narrow_synonym: TRAIL biosynthetic process
has_obo_namespace: biological_process
id: GO:0032639
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: TRAIL production
annotated property: definition
annotated target: The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:9311998

tumor necrosis factor production
type: Class
subclass of: tumor necrosis factor superfamily cytokine production
definition: The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
created by: sl
creation date: 2015-06-15T22:59:26Z
has_alternative_id: GO:0042533
has_alternative_id: GO:1990774
has_exact_synonym: TNF production
has_exact_synonym: cachectin production
has_narrow_synonym: TNF alpha biosynthesis
has_narrow_synonym: TNF biosynthesis
has_narrow_synonym: TNF biosynthetic process
has_narrow_synonym: TNF-alpha biosynthesis
has_narrow_synonym: TNF-alpha biosynthetic process
has_narrow_synonym: tumor necrosis factor anabolism
has_narrow_synonym: tumor necrosis factor biosynthesis
has_narrow_synonym: tumor necrosis factor biosynthetic process
has_narrow_synonym: tumor necrosis factor formation
has_narrow_synonym: tumor necrosis factor secretion
has_narrow_synonym: tumor necrosis factor synthesis
has_obo_namespace: biological_process
has_related_synonym: TNF-alpha production
has_related_synonym: Tnfa production
has_related_synonym: tumor necrosis factor-alpha production
id: GO:0032640
in_subset: gocheck do not annotate
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: tumor necrosis factor production
annotated property: definition
annotated target: The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
database_cross_reference: GOC:mah
database_cross_reference: PMID:10891884
database_cross_reference: PMID:15560120

lymphotoxin A production
type: Class
subclass of: protein metabolic process
subclass of: tumor necrosis factor superfamily cytokine production
definition: The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.
has_alternative_id: GO:0042109
has_exact_synonym: LTA production
has_exact_synonym: TNF-B production
has_exact_synonym: TNF-beta production
has_exact_synonym: lymphotoxin-alpha production
has_exact_synonym: tumor necrosis factor-beta production
has_narrow_synonym: lymphotoxin A biosynthetic process
has_narrow_synonym: lymphotoxin A synthesis
has_obo_namespace: biological_process
has_related_synonym: lymphotoxin A formation
id: GO:0032641
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: lymphotoxin A production
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.
database_cross_reference: GOC:jl

mast cell cytokine production
type: Class
subclass of: myeloid leukocyte cytokine production
definition: Any process that contributes to cytokine production by a mast cell.
has_obo_namespace: biological_process
id: GO:0032762
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: mast cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a mast cell.
database_cross_reference: GOC:mah

RNA biosynthetic process
type: Class
subclass of: nucleic acid biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
has_alternative_id: GO:0062103
has_exact_synonym: RNA anabolism
has_exact_synonym: RNA biosynthesis
has_exact_synonym: RNA formation
has_exact_synonym: RNA synthesis
has_narrow_synonym: double-stranded RNA biosynthesis
has_narrow_synonym: double-stranded RNA biosynthetic process
has_narrow_synonym: dsRNA biosynthesis
has_narrow_synonym: dsRNA biosynthetic process
has_obo_namespace: biological_process
id: GO:0032774
in_subset: gocheck do not annotate
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.

Axiom
annotated source: RNA biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.
database_cross_reference: GOC:mah
database_cross_reference: GOC:txnOH

Axiom
annotated source: RNA biosynthetic process
annotated property: has_narrow_synonym
annotated target: dsRNA biosynthetic process
database_cross_reference: GOC:BHF
database_cross_reference: GOC:BHF_telomere
database_cross_reference: GOC:nc
database_cross_reference: GOC:rl

regulation of localization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: localization
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: localization
definition: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_exact_synonym: regulation of localisation
has_obo_namespace: biological_process
id: GO:0032879
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of localization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of localization
annotated property: has_exact_synonym
annotated target: regulation of localisation
database_cross_reference: GOC:mah

macromolecule localization
type: Class
subclass of: localization
definition: Any process in which a macromolecule is transported to, or maintained in, a specific location.
has_exact_synonym: macromolecule localisation
has_obo_namespace: biological_process
id: GO:0033036
in_subset: gocheck do not annotate
in_subset: goslim flybase ribbon

Axiom
annotated source: macromolecule localization
annotated property: definition
annotated target: Any process in which a macromolecule is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule localization
annotated property: has_exact_synonym
annotated target: macromolecule localisation
database_cross_reference: GOC:mah

regulation of organelle organization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: organelle organization
subclass of: regulation of cellular component organization
subclass of: Restriction
  on property: regulates
  some values from: organelle organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
has_exact_synonym: regulation of organelle organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of organelle organization and biogenesis
id: GO:0033043
in_subset: gocheck do not annotate
in_subset: goslim yeast

Axiom
annotated source: regulation of organelle organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_exact_synonym
annotated target: regulation of organelle organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of organelle organization
annotated property: has_related_synonym
annotated target: regulation of organelle organization and biogenesis
database_cross_reference: GOC:mah

protein localization to organelle
type: Class
subclass of: macromolecule localization
definition: A process in which a protein is transported to, or maintained in, a location within an organelle.
has_exact_synonym: protein localisation to organelle
has_exact_synonym: protein localization in organelle
has_obo_namespace: biological_process
id: GO:0033365
in_subset: gocheck do not annotate

Axiom
annotated source: protein localization to organelle
annotated property: definition
annotated target: A process in which a protein is transported to, or maintained in, a location within an organelle.
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to organelle
annotated property: has_exact_synonym
annotated target: protein localisation to organelle
database_cross_reference: GOC:mah

Axiom
annotated source: protein localization to organelle
annotated property: has_exact_synonym
annotated target: protein localization in organelle
database_cross_reference: GOC:mah

host cell part
type: Class
subclass of: other organism part
definition: Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_obo_namespace: cellular_component
id: GO:0033643
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host cell part
annotated property: definition
annotated target: Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host intracellular part
type: Class
subclass of: host cell part
subclass of: Restriction
  on property: part of
  some values from: host cell part
definition: Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: host cell intracellular part
has_obo_namespace: cellular_component
id: GO:0033646
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host intracellular part
annotated property: definition
annotated target: Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host cell chloroplast part
type: Class
subclass of: host intracellular part
definition: Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_exact_synonym: host chloroplast component
has_obo_namespace: cellular_component
id: GO:0033653
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host cell chloroplast part
annotated property: definition
annotated target: Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

host cell cytoplasm part
type: Class
subclass of: host intracellular part
subclass of: Restriction
  on property: part of
  some values from: host intracellular part
definition: Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction.
has_broad_synonym: cytoplasm component
has_obo_namespace: cellular_component
id: GO:0033655
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host cell cytoplasm part
annotated property: definition
annotated target: Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:pamgo_curators

protein N-acetyltransferase activity
type: Class
definition: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.
term tracker item: https://github.com/geneontology/go-ontology/issues/29507
database_cross_reference: Reactome:R-HSA-3371554
database_cross_reference: Reactome:R-HSA-9760081
has_exact_synonym: peptide N-acetyltransferase activity
has_obo_namespace: molecular_function
id: GO:0034212
in_subset: gocheck do not annotate

Axiom
annotated source: protein N-acetyltransferase activity
annotated property: definition
annotated target: Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.
database_cross_reference: GOC:mah

HSF1 acetylation at Lys80
type: Axiom
annotated source: protein N-acetyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3371554

CREBBP, EP300 acetylates NFE2L2
type: Axiom
annotated source: protein N-acetyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9760081

nucleobase-containing compound biosynthetic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid anabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid formation
has_narrow_synonym: nucleobase, nucleoside, nucleotide and nucleic acid synthesis
has_obo_namespace: biological_process
id: GO:0034654
in_subset: gocheck do not annotate

Axiom
annotated source: nucleobase-containing compound biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:mah

nucleobase-containing compound catabolic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid breakdown
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid degradation
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
id: GO:0034655
in_subset: gocheck do not annotate
in_subset: goslim chembl

Axiom
annotated source: nucleobase-containing compound catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:mah

Axiom
annotated source: nucleobase-containing compound catabolic process
annotated property: has_related_synonym
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

chemokine (C-X-C motif) ligand 9 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2010-03-23T10:03:20Z
has_exact_synonym: CXCL9 production
has_exact_synonym: MIG production
has_exact_synonym: Monokine induced by gamma interferon production
has_obo_namespace: biological_process
id: GO:0035393
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 9 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add

chemokine (C-C motif) ligand 6 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2010-05-07T10:21:15Z
has_exact_synonym: CCL6 production
has_obo_namespace: biological_process
id: GO:0035530
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 6 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: PMID:19812544

negative regulation of chromatin binding
type: Class
subclass of: negative regulation of binding
definition: Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
created by: bf
creation date: 2010-05-19T10:29:06Z
has_obo_namespace: biological_process
id: GO:0035562
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of chromatin binding
annotated property: definition
annotated target: Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
database_cross_reference: GOC:bf
database_cross_reference: PMID:20404130

positive regulation of chromatin binding
type: Class
subclass of: positive regulation of binding
definition: Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
created by: bf
creation date: 2010-05-19T10:29:41Z
has_obo_namespace: biological_process
id: GO:0035563
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of chromatin binding
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
database_cross_reference: GOC:bf
database_cross_reference: PMID:20404130

CD4-positive, alpha-beta T cell cytokine production
type: Class
subclass of: T cell cytokine production
definition: Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell.
created by: bf
creation date: 2011-03-17T02:21:51Z
has_obo_namespace: biological_process
id: GO:0035743
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: CD4-positive, alpha-beta T cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell.
database_cross_reference: CL:0000624
database_cross_reference: GOC:BHF

T-helper 1 cell cytokine production
type: Class
subclass of: CD4-positive, alpha-beta T cell cytokine production
definition: Any process that contributes to cytokine production by a T-helper 1 cell.
created by: bf
creation date: 2011-03-17T02:22:54Z
has_exact_synonym: Th1 cell cytokine production
has_obo_namespace: biological_process
id: GO:0035744
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: T-helper 1 cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a T-helper 1 cell.
database_cross_reference: CL:0000545
database_cross_reference: GOC:BHF

Axiom
annotated source: T-helper 1 cell cytokine production
annotated property: has_exact_synonym
annotated target: Th1 cell cytokine production
database_cross_reference: CL:0000545

T-helper 2 cell cytokine production
type: Class
subclass of: CD4-positive, alpha-beta T cell cytokine production
definition: Any process that contributes to cytokine production by a T-helper 2 cell.
created by: bf
creation date: 2011-03-17T02:23:32Z
has_exact_synonym: Th2 cell cytokine production
has_obo_namespace: biological_process
id: GO:0035745
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: T-helper 2 cell cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a T-helper 2 cell.
database_cross_reference: CL:0000546
database_cross_reference: GOC:BHF

Axiom
annotated source: T-helper 2 cell cytokine production
annotated property: has_exact_synonym
annotated target: Th2 cell cytokine production
database_cross_reference: CL:0000546

granzyme A production
type: Class
subclass of: production of molecular mediator of immune response
definition: The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2011-03-17T02:39:11Z
has_obo_namespace: biological_process
id: GO:0035746
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: granzyme A production
annotated property: definition
annotated target: The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF

perforin production
type: Class
subclass of: production of molecular mediator of immune response
definition: The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2011-07-27T11:44:21Z
has_obo_namespace: biological_process
id: GO:0035944
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: perforin production
annotated property: definition
annotated target: The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

protein modification process
type: Class
subclass of: protein metabolic process
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
created by: bf
creation date: 2012-04-26T01:47:12Z
has_alternative_id: GO:0006464
has_exact_synonym: cellular protein modification process
has_exact_synonym: process resulting in protein modification
has_exact_synonym: protein modification
has_obo_namespace: biological_process
id: GO:0036211
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote

Axiom
annotated source: protein modification process
annotated property: definition
annotated target: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

Axiom
annotated source: protein modification process
annotated property: has_exact_synonym
annotated target: protein modification
database_cross_reference: GOC:bf

granulysin production
type: Class
subclass of: production of molecular mediator of immune response
definition: The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2012-06-18T02:11:15Z
has_obo_namespace: biological_process
id: GO:0036262
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: granulysin production
annotated property: definition
annotated target: The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

response to diuretic
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
created by: bf
creation date: 2012-07-09T01:26:24Z
has_obo_namespace: biological_process
id: GO:0036270
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to diuretic
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
database_cross_reference: GOC:hp

response to methylphenidate
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
created by: bf
creation date: 2012-07-09T01:30:57Z
has_exact_synonym: response to MPD
has_exact_synonym: response to MPH
has_exact_synonym: response to ritalin
has_obo_namespace: biological_process
id: GO:0036271
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to methylphenidate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Methylphenidate

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPD
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPH
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to ritalin
database_cross_reference: CHEBI:6887

response to gemcitabine
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
created by: bf
creation date: 2012-07-09T01:36:03Z
has_exact_synonym: response to 2',2'-difluorodeoxycytidine
has_exact_synonym: response to 2'-deoxy-2',2'-difluorocytidine
has_obo_namespace: biological_process
id: GO:0036272
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to gemcitabine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Gemcitabine

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2',2'-difluorodeoxycytidine
database_cross_reference: CHEBI:175901

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2'-deoxy-2',2'-difluorocytidine
database_cross_reference: CHEBI:175901

response to statin
type: Class
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
created by: bf
creation date: 2012-07-09T01:54:01Z
has_obo_namespace: biological_process
has_related_synonym: response to HMG-CoA reductase inhibitor
has_related_synonym: response to hydroxymethylglutaryl-CoA reductase inhibitor
id: GO:0036273
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to statin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
database_cross_reference: GOC:hp

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to HMG-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to hydroxymethylglutaryl-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

response to lapatinib
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
created by: bf
creation date: 2012-07-09T02:02:26Z
has_obo_namespace: biological_process
id: GO:0036274
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to lapatinib
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
database_cross_reference: GOC:hp

response to 5-fluorouracil
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
created by: bf
creation date: 2012-07-09T02:08:23Z
has_exact_synonym: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
has_exact_synonym: response to fluorouracil
has_obo_namespace: biological_process
id: GO:0036275
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to 5-fluorouracil
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
database_cross_reference: GOC:hp

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
database_cross_reference: CHEBI:46345

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to fluorouracil
database_cross_reference: GOC:hp

response to antidepressant
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
created by: bf
creation date: 2012-07-09T02:12:44Z
has_obo_namespace: biological_process
id: GO:0036276
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to antidepressant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
database_cross_reference: GOC:hp

response to anticonvulsant
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
created by: bf
creation date: 2012-07-09T02:40:12Z
has_obo_namespace: biological_process
id: GO:0036277
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to anticonvulsant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
database_cross_reference: GOC:hp

response to iloperidone
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
created by: bf
creation date: 2012-07-16T05:01:29Z
has_obo_namespace: biological_process
id: GO:0036287
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to iloperidone
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
database_cross_reference: GOC:hp

response to ximelagatran
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
created by: bf
creation date: 2012-07-16T05:03:56Z
has_obo_namespace: biological_process
id: GO:0036288
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to ximelagatran
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
database_cross_reference: GOC:hp

macrophage colony-stimulating factor production
type: Class
subclass of: cytokine production
definition: The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2012-08-07T14:07:13Z
has_exact_synonym: M-CSF production
has_obo_namespace: biological_process
id: GO:0036301
in_subset: gocheck do not annotate

Axiom
annotated source: macrophage colony-stimulating factor production
annotated property: definition
annotated target: The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:vk

Axiom
annotated source: macrophage colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: M-CSF production
database_cross_reference: GOC:vk

chemokine (C-C motif) ligand 20 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bf
creation date: 2013-06-17T14:42:07Z
has_exact_synonym: C-C motif chemokine 20 production
has_exact_synonym: CCL-20 production
has_exact_synonym: CCL20 production
has_obo_namespace: biological_process
id: GO:0036392
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 20 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:jc

bile acid signaling pathway
type: Class
subclass of: cellular process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: part of
  some values from: regulation of biological process
subclass of: Restriction
  on property: part of
  some values from: cellular response to stimulus
definition: The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/26958
created by: bf
creation date: 2013-05-16T10:35:10Z
has_obo_namespace: biological_process
id: GO:0038183
in_subset: gocheck do not annotate
comment: This term is not for direct annotation. Please use a more specific child: 'cell surface bile acid receptor signaling pathway' for GPCRs and 'intracellular bile acid receptor signaling pathway' for nuclear receptors.

Axiom
annotated source: bile acid signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
database_cross_reference: GOC:signaling
database_cross_reference: PMID:12016314
database_cross_reference: PMID:36409000

growth
type: Class
disjoint with: biological phase
definition: The increase in size or mass of an entire organism, a part of an organism or a cell.
has_alternative_id: GO:0048590
has_obo_namespace: biological_process
has_related_synonym: growth pattern
has_related_synonym: non-developmental growth
id: GO:0040007
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim plant
comment: See also the biological process term 'cell growth ; GO:0016049'.

Axiom
annotated source: growth
annotated property: definition
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ma

Axiom
annotated source: growth
annotated property: has_related_synonym
annotated target: non-developmental growth
database_cross_reference: GOC:mah

response to chemical
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
has_exact_synonym: response to chemical stimulus
has_exact_synonym: response to chemical substance
has_obo_namespace: biological_process
id: GO:0042221
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to chemical
annotated property: has_exact_synonym
annotated target: response to chemical stimulus
database_cross_reference: GOC:dos

catagen
type: Class
subclass of: hair cycle phase
subclass of: Restriction
  on property: part of
  some values from: multicellular organismal process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.
has_narrow_synonym: hair regression
has_obo_namespace: biological_process
id: GO:0042637
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: catagen
annotated property: definition
annotated target: The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.
database_cross_reference: PMID:12535193

exogen
type: Class
subclass of: hair cycle phase
subclass of: Restriction
  on property: part of
  some values from: multicellular organismal process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The shedding phase of the hair cycle.
has_narrow_synonym: hair shedding
has_obo_namespace: biological_process
id: GO:0042638
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: exogen
annotated property: definition
annotated target: The shedding phase of the hair cycle.
database_cross_reference: PMID:12230507

telogen
type: Class
subclass of: hair cycle phase
definition: The resting phase of hair cycle.
has_narrow_synonym: hair resting phase
has_obo_namespace: biological_process
id: GO:0042639
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: telogen
annotated property: definition
annotated target: The resting phase of hair cycle.
database_cross_reference: PMID:12230507

anagen
type: Class
subclass of: hair cycle phase
subclass of: Restriction
  on property: part of
  some values from: multicellular organismal process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.
has_obo_namespace: biological_process
has_related_synonym: hair growth
id: GO:0042640
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: anagen
annotated property: definition
annotated target: The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.
database_cross_reference: PMID:12230507

menarche
type: Class
subclass of: menstrual cycle phase
definition: The beginning of the menstrual cycle; the first menstrual cycle in an individual.
database_cross_reference: Wikipedia:Menarche
has_obo_namespace: biological_process
id: GO:0042696
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: menarche
annotated property: definition
annotated target: The beginning of the menstrual cycle; the first menstrual cycle in an individual.
database_cross_reference: GOC:curators
database_cross_reference: PMID:16311040

menopause
type: Class
subclass of: menstrual cycle phase
subclass of: reproductive senescence
definition: Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50.
database_cross_reference: Wikipedia:Menopause
has_obo_namespace: biological_process
id: GO:0042697
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: menopause
annotated property: definition
annotated target: Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50.
database_cross_reference: GOC:curators
database_cross_reference: PMID:18495681

menstruation
type: Class
subclass of: menstrual cycle phase
definition: The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.
database_cross_reference: Wikipedia:Menstruation
has_obo_namespace: biological_process
id: GO:0042703
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: menstruation
annotated property: definition
annotated target: The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.
database_cross_reference: GOC:curators
database_cross_reference: PMID:8693059

biofilm formation
type: Class
subclass of: cellular process
definition: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/17727
database_cross_reference: Reactome:R-HSA-9931953
has_obo_namespace: biological_process
id: GO:0042710
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: biofilm formation
annotated property: definition
annotated target: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
database_cross_reference: GOC:di
database_cross_reference: PMID:11932229

Biofilm formation
type: Axiom
annotated source: biofilm formation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9931953

cell projection
type: Class
subclass of: cellular anatomical structure
definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
term tracker item: https://github.com/geneontology/go-ontology/issues/23013
has_broad_synonym: cell process
has_broad_synonym: cellular process
has_exact_synonym: cellular projection
has_obo_namespace: cellular_component
id: GO:0042995
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: cell projection
annotated property: definition
annotated target: A prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16318917

regulation of GTPase activity
type: Class
subclass of: biological regulation
definition: Any process that modulates the rate of GTP hydrolysis by a GTPase.
has_alternative_id: GO:0032312
has_alternative_id: GO:0032313
has_alternative_id: GO:0032314
has_alternative_id: GO:0032315
has_alternative_id: GO:0032316
has_alternative_id: GO:0032317
has_alternative_id: GO:0032318
has_alternative_id: GO:0032319
has_alternative_id: GO:0043088
has_narrow_synonym: regulation of ARF GTPase activity
has_narrow_synonym: regulation of Cdc42 GTPase activity
has_narrow_synonym: regulation of Rab GTPase activity
has_narrow_synonym: regulation of Rac GTPase activity
has_narrow_synonym: regulation of Ral GTPase activity
has_narrow_synonym: regulation of Ran GTPase activity
has_narrow_synonym: regulation of Rap GTPase activity
has_narrow_synonym: regulation of Ras GTPase activity
has_narrow_synonym: regulation of Rho GTPase activity
has_obo_namespace: biological_process
id: GO:0043087
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of GTPase activity
annotated property: definition
annotated target: Any process that modulates the rate of GTP hydrolysis by a GTPase.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

ion binding
type: Class
definition: Binding to an ion, a charged atoms or groups of atoms.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_obo_namespace: molecular_function
has_related_synonym: atom binding
id: GO:0043167
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: ion binding
annotated property: definition
annotated target: Binding to an ion, a charged atoms or groups of atoms.
database_cross_reference: GOC:jl

macromolecule metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_alternative_id: GO:0034960
has_alternative_id: GO:0043283
has_alternative_id: GO:0044259
has_exact_synonym: biopolymer metabolic process
has_exact_synonym: macromolecule metabolism
has_exact_synonym: organismal macromolecule metabolism
has_narrow_synonym: multicellular organismal macromolecule metabolic process
has_obo_namespace: biological_process
id: GO:0043170
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: macromolecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:mah

Axiom
annotated source: macromolecule metabolic process
annotated property: has_exact_synonym
annotated target: biopolymer metabolic process
database_cross_reference: GOC:mtg_chebi_dec09

membrane-bounded organelle
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: has part
  some values from: cellular anatomical structure
definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/28153
database_cross_reference: NIF_Subcellular:sao414196390
has_exact_synonym: membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043227
in_subset: gocheck do not annotate

Axiom
annotated source: membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
database_cross_reference: GOC:curators

membraneless organelle
type: Class
subclass of: cellular anatomical structure
definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
term tracker item: https://github.com/geneontology/go-ontology/issues/21881
term tracker item: https://github.com/geneontology/go-ontology/issues/28153
term tracker item: https://github.com/geneontology/go-ontology/issues/29106
database_cross_reference: NIF_Subcellular:sao1456184038
has_exact_synonym: membrane-less organelle
has_exact_synonym: non-membrane-bounded organelle
has_exact_synonym: non-membrane-enclosed organelle
has_obo_namespace: cellular_component
has_related_synonym: biological condensate
id: GO:0043228
in_subset: gocheck do not annotate
in_subset: goslim mouse

Axiom
annotated source: membraneless organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: GOC:curators

intracellular organelle
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/28153
has_obo_namespace: cellular_component
id: GO:0043229
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: intracellular organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:curators

intracellular membrane-bounded organelle
type: Class
equivalent class: Class
  intersection of: membrane-bounded organelle
  intersection of: Restriction
    on property: part of
    some values from: intracellular anatomical structure
subclass of: membrane-bounded organelle
subclass of: intracellular organelle
definition: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
has_exact_synonym: intracellular membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043231
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: intracellular membrane-bounded organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
database_cross_reference: GOC:curators

intracellular membraneless organelle
type: Class
equivalent class: Class
  intersection of: membraneless organelle
  intersection of: Restriction
    on property: part of
    some values from: intracellular anatomical structure
subclass of: membraneless organelle
subclass of: intracellular organelle
definition: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
term tracker item: https://github.com/geneontology/go-ontology/issues/29106
has_exact_synonym: intracellular non-membrane-bounded organelle
has_exact_synonym: intracellular non-membrane-enclosed organelle
has_obo_namespace: cellular_component
id: GO:0043232
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: intracellular membraneless organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
database_cross_reference: GOC:curators

positive regulation of DNA binding
type: Class
subclass of: positive regulation of binding
subclass of: regulation of DNA binding
definition: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
has_exact_synonym: up regulation of DNA binding
has_exact_synonym: up-regulation of DNA binding
has_exact_synonym: upregulation of DNA binding
has_narrow_synonym: activation of DNA binding
has_narrow_synonym: stimulation of DNA binding
has_obo_namespace: biological_process
id: GO:0043388
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of DNA binding
annotated property: definition
annotated target: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb

negative regulation of DNA binding
type: Class
subclass of: negative regulation of binding
subclass of: regulation of DNA binding
definition: Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
has_exact_synonym: down regulation of DNA binding
has_exact_synonym: down-regulation of DNA binding
has_exact_synonym: downregulation of DNA binding
has_narrow_synonym: inhibition of DNA binding
has_obo_namespace: biological_process
id: GO:0043392
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of DNA binding
annotated property: definition
annotated target: Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb

regulation of protein binding
type: Class
subclass of: regulation of binding
definition: Any process that modulates the frequency, rate or extent of protein binding.
has_obo_namespace: biological_process
id: GO:0043393
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of protein binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of protein binding.
database_cross_reference: GOC:curators

pilus organization
type: Class
subclass of: cell projection organization
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies.
has_exact_synonym: pilus organisation
has_obo_namespace: biological_process
has_related_synonym: pilus organization and biogenesis
id: GO:0043711
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction.

Axiom
annotated source: pilus organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies.
database_cross_reference: GOC:jl

Axiom
annotated source: pilus organization
annotated property: has_exact_synonym
annotated target: pilus organisation
database_cross_reference: GOC:mah

Axiom
annotated source: pilus organization
annotated property: has_related_synonym
annotated target: pilus organization and biogenesis
database_cross_reference: GOC:mah

cellular component maintenance
type: Class
subclass of: cellular component organization
definition: The organization process that preserves a cellular component in a stable functional or structural state.
has_alternative_id: GO:0071956
has_exact_synonym: cellular component maintenance at cellular level
has_obo_namespace: biological_process
id: GO:0043954
in_subset: gocheck do not annotate

Axiom
annotated source: cellular component maintenance
annotated property: definition
annotated target: The organization process that preserves a cellular component in a stable functional or structural state.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

cellular component biogenesis
type: Class
subclass of: cellular component organization or biogenesis
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
term tracker item: https://github.com/geneontology/go-ontology/issues/27194
has_alternative_id: GO:0071843
has_exact_synonym: cellular component biogenesis at cellular level
has_obo_namespace: biological_process
id: GO:0044085
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: cellular component biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

regulation of cellular component biogenesis
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular component biogenesis
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cellular component biogenesis
definition: Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
has_obo_namespace: biological_process
id: GO:0044087
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of cellular component biogenesis
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
database_cross_reference: GOC:jl

negative regulation of molecular function
type: Class
subclass of: biological regulation
definition: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
created by: jl
creation date: 2009-04-21T04:07:27Z
has_obo_namespace: biological_process
id: GO:0044092
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of molecular function
annotated property: definition
annotated target: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GO:jl

host cell nuclear part
type: Class
subclass of: host intracellular part
subclass of: Restriction
  on property: part of
  some values from: host intracellular part
definition: Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction.
created by: jl
creation date: 2009-04-22T01:59:14Z
has_obo_namespace: cellular_component
id: GO:0044094
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: host cell nuclear part
annotated property: definition
annotated target: Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction.
database_cross_reference: GOC:ecd

other organism part
type: Class
subclass of: cellular anatomical structure
definition: Any constituent part of a secondary organism with which the first organism is interacting.
created by: jl
creation date: 2009-11-12T01:18:21Z
has_obo_namespace: cellular_component
id: GO:0044217
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: other organism part
annotated property: definition
annotated target: Any constituent part of a secondary organism with which the first organism is interacting.
database_cross_reference: GOC:jl

primary metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
database_cross_reference: Reactome:R-HSA-71291
database_cross_reference: Wikipedia:Primary_metabolite
has_exact_synonym: primary metabolism
has_obo_namespace: biological_process
id: GO:0044238
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon

Axiom
annotated source: primary metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
database_cross_reference: GOC:curators

Metabolism of amino acids and derivatives
type: Axiom
annotated source: primary metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-71291

small molecule metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: jl
creation date: 2010-01-26T12:05:20Z
has_exact_synonym: small molecule metabolism
has_obo_namespace: biological_process
id: GO:0044281
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

small molecule catabolic process
type: Class
subclass of: catabolic process
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: jl
creation date: 2010-01-26T12:06:10Z
has_exact_synonym: small molecule catabolism
has_obo_namespace: biological_process
id: GO:0044282
in_subset: gocheck do not annotate
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:vw

small molecule biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: small molecule metabolic process
definition: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: jl
creation date: 2010-01-26T12:06:49Z
has_exact_synonym: small molecule biosynthesis
has_obo_namespace: biological_process
id: GO:0044283
in_subset: gocheck do not annotate
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

biological process involved in interspecies interaction between organisms
type: Class
definition: Any process evolved to enable an interaction with an organism of a different species.
term tracker item: https://github.com/geneontology/go-ontology/issues/20191
database_cross_reference: Reactome:R-HSA-9824443
has_exact_synonym: interaction with another species
has_exact_synonym: interspecies interaction
has_exact_synonym: interspecies interaction between organisms
has_exact_synonym: interspecies interaction with other organisms
has_obo_namespace: biological_process
id: GO:0044419
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: biological process involved in interspecies interaction between organisms
annotated property: definition
annotated target: Any process evolved to enable an interaction with an organism of a different species.
database_cross_reference: GOC:cc

Parasitic Infection Pathways
type: Axiom
annotated source: biological process involved in interspecies interaction between organisms
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9824443

glial cell-derived neurotrophic factor production
type: Class
subclass of: cytokine production
definition: The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons.
created by: jl
creation date: 2012-01-17T04:26:05Z
has_exact_synonym: GDNF production
has_narrow_synonym: glial cell-derived neurotrophic factor secretion
has_obo_namespace: biological_process
has_related_synonym: glial cell line-derived neurotrophic factor production
id: GO:0044467
in_subset: gocheck do not annotate

Axiom
annotated source: glial cell-derived neurotrophic factor production
annotated property: definition
annotated target: The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons.
database_cross_reference: GOC:yaf
database_cross_reference: PMID:17505307

multi-organism reproductive process
type: Class
subclass of: reproductive process
definition: A biological process that directly contributes to the process of producing new individuals, involving another organism.
created by: jl
creation date: 2012-09-19T15:56:30Z
has_obo_namespace: biological_process
id: GO:0044703
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: multi-organism reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals, involving another organism.
database_cross_reference: GOC:jl

macrophage migration inhibitory factor production
type: Class
subclass of: cytokine production
definition: The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: jl
creation date: 2013-09-11T12:04:09Z
has_exact_synonym: MIF production
has_obo_namespace: biological_process
id: GO:0044807
in_subset: gocheck do not annotate

Axiom
annotated source: macrophage migration inhibitory factor production
annotated property: definition
annotated target: The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

oncostatin M production
type: Class
subclass of: cytokine production
definition: The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: jl
creation date: 2013-09-11T12:18:00Z
has_exact_synonym: OSM production
has_obo_namespace: biological_process
id: GO:0044808
in_subset: gocheck do not annotate

Axiom
annotated source: oncostatin M production
annotated property: definition
annotated target: The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

chemokine (C-C motif) ligand 17 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: jl
creation date: 2013-09-11T12:21:31Z
has_exact_synonym: CCL17 production
has_exact_synonym: TARC production
has_exact_synonym: thymus and activation regulated chemokine production
has_obo_namespace: biological_process
id: GO:0044809
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 17 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

cell quiescence
type: Class
subclass of: cell cycle phase
definition: A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.
created by: jl
creation date: 2014-02-26T16:15:51Z
has_broad_synonym: quiescence
has_exact_synonym: cellular quiescence
has_obo_namespace: biological_process
has_related_synonym: G0 phase
has_related_synonym: cell cycle quiescence
id: GO:0044838
in_subset: gocheck do not annotate
comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: cell quiescence
annotated property: definition
annotated target: A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed.
database_cross_reference: GOC:jb
database_cross_reference: GOC:mah

Axiom
annotated source: cell quiescence
annotated property: has_broad_synonym
annotated target: quiescence
database_cross_reference: GOC:mah

Axiom
annotated source: cell quiescence
annotated property: has_exact_synonym
annotated target: cellular quiescence
database_cross_reference: GOC:mah

Axiom
annotated source: cell quiescence
annotated property: has_related_synonym
annotated target: G0 phase
database_cross_reference: GOC:mah

Axiom
annotated source: cell quiescence
annotated property: has_related_synonym
annotated target: cell cycle quiescence
database_cross_reference: GOC:mah

meiotic interphase II
type: Class
subclass of: meiotic interphase
subclass of: meiosis II cell cycle phase
definition: The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge.
created by: jl
creation date: 2014-03-26T16:52:27Z
has_obo_namespace: biological_process
id: GO:0044844
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic interphase II
annotated property: definition
annotated target: The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mtg_cell_cycle

biological phase
type: Class
disjoint with: response to stimulus
disjoint with: localization
disjoint with: cellular component organization or biogenesis
definition: A distinct period or stage in a biological process or cycle.
created by: jl
creation date: 2014-07-16T13:12:40Z
has_obo_namespace: biological_process
id: GO:0044848
in_subset: gocheck do not annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: biological phase
annotated property: definition
annotated target: A distinct period or stage in a biological process or cycle.
database_cross_reference: GOC:jl

hair cycle phase
type: Class
subclass of: biological phase
definition: The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
created by: jl
creation date: 2014-07-16T14:22:09Z
has_obo_namespace: biological_process
id: GO:0044851
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: hair cycle phase
annotated property: definition
annotated target: The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
database_cross_reference: GOC:jl

tricarboxylic acid cycle heteromeric enzyme complex
type: Class
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: Any of the heteromeric enzymes that act in the TCA cycle.
has_exact_synonym: TCA cycle enzyme complex
has_obo_namespace: cellular_component
id: GO:0045239
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: tricarboxylic acid cycle heteromeric enzyme complex
annotated property: definition
annotated target: Any of the heteromeric enzymes that act in the TCA cycle.
database_cross_reference: GOC:mah

negative regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleobase-containing compound metabolic process
definition: Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
has_exact_synonym: down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_narrow_synonym: inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_obo_namespace: biological_process
has_related_synonym: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
id: GO:0045934
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of nucleobase-containing compound metabolic process
annotated property: definition
annotated target: Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:curators

Axiom
annotated source: negative regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym
annotated target: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

alcohol catabolic process
type: Class
subclass of: alcohol metabolic process
subclass of: small molecule catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
has_exact_synonym: alcohol breakdown
has_exact_synonym: alcohol catabolism
has_exact_synonym: alcohol degradation
has_obo_namespace: biological_process
id: GO:0046164
in_subset: gocheck do not annotate

Axiom
annotated source: alcohol catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
database_cross_reference: GOC:ai

alcohol biosynthetic process
type: Class
subclass of: alcohol metabolic process
subclass of: small molecule biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
has_exact_synonym: alcohol anabolism
has_exact_synonym: alcohol biosynthesis
has_exact_synonym: alcohol formation
has_exact_synonym: alcohol synthesis
has_obo_namespace: biological_process
id: GO:0046165
in_subset: gocheck do not annotate

Axiom
annotated source: alcohol biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
database_cross_reference: GOC:ai

sphingolipid intramembrane carrier activity
type: Class
subclass of: transporter activity
subclass of: Restriction
  on property: part of
  some values from: transport
subclass of: Restriction
  on property: part of
  some values from: cellular component organization
subclass of: Restriction
  on property: part of
  some values from: macromolecule localization
subclass of: Restriction
  on property: part of
  some values from: regulation of biological quality
definition: Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
term tracker item: https://github.com/geneontology/go-ontology/issues/31121
term tracker item: https://github.com/geneontology/go-ontology/issues/31454
has_broad_synonym: sphingolipid intramembrane transporter activity
database_cross_reference: Reactome:R-HSA-9695890
database_cross_reference: Reactome:R-HSA-9843721
has_obo_namespace: molecular_function
id: GO:0046624
in_subset: gocheck do not annotate

Axiom
annotated source: sphingolipid intramembrane carrier activity
annotated property: definition
annotated target: Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
database_cross_reference: GOC:ai
database_cross_reference: ISBN:0198506732

SPNS2,MFSD2B transport S1P from cytosol to extracellular region
type: Axiom
annotated source: sphingolipid intramembrane carrier activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9695890

ABCC1,ABCG2 transport C18-S1P to extracellular region
type: Axiom
annotated source: sphingolipid intramembrane carrier activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9843721

intracellular transport
type: Class
equivalent class: Class
  intersection of: transport
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular anatomical structure
subclass of: transport
subclass of: cellular localization
subclass of: Restriction
  on property: part of
  some values from: cellular localization
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
definition: The directed movement of substances within a cell.
created by: jl
creation date: 2013-12-18T14:04:50Z
has_alternative_id: GO:1902582
has_obo_namespace: biological_process
has_related_synonym: single organism intracellular transport
has_related_synonym: single-organism intracellular transport
id: GO:0046907
in_subset: gocheck do not annotate

Axiom
annotated source: intracellular transport
annotated property: definition
annotated target: The directed movement of substances within a cell.
database_cross_reference: GOC:ai

Axiom
annotated source: intracellular transport
annotated property: has_related_synonym
annotated target: single organism intracellular transport
database_cross_reference: GOC:TermGenie

positive regulation of biological process
type: Class
subclass of: regulation of biological process
definition: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043119
has_exact_synonym: positive regulation of physiological process
has_exact_synonym: up regulation of biological process
has_exact_synonym: up-regulation of biological process
has_exact_synonym: upregulation of biological process
has_narrow_synonym: activation of biological process
has_narrow_synonym: stimulation of biological process
has_obo_namespace: biological_process
id: GO:0048518
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of biological process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid

negative regulation of biological process
type: Class
subclass of: regulation of biological process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043118
has_exact_synonym: down regulation of biological process
has_exact_synonym: down-regulation of biological process
has_exact_synonym: downregulation of biological process
has_exact_synonym: negative regulation of physiological process
has_narrow_synonym: inhibition of biological process
has_obo_namespace: biological_process
id: GO:0048519
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of biological process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid

positive regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: cellular process
subclass of: positive regulation of biological process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: positively regulates
  some values from: cellular process
definition: Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0051242
has_exact_synonym: positive regulation of cellular physiological process
has_exact_synonym: up regulation of cellular process
has_exact_synonym: up-regulation of cellular process
has_exact_synonym: upregulation of cellular process
has_narrow_synonym: activation of cellular process
has_narrow_synonym: stimulation of cellular process
has_obo_namespace: biological_process
id: GO:0048522
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of cellular process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:jid

negative regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: cellular process
subclass of: negative regulation of biological process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0051243
has_exact_synonym: down regulation of cellular process
has_exact_synonym: down-regulation of cellular process
has_exact_synonym: downregulation of cellular process
has_exact_synonym: negative regulation of cellular physiological process
has_narrow_synonym: inhibition of cellular process
has_obo_namespace: biological_process
id: GO:0048523
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of cellular process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:jid

regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: response to stimulus
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: response to stimulus
definition: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_obo_namespace: biological_process
id: GO:0048583
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

positive regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: response to stimulus
subclass of: positive regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to stimulus
definition: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: up regulation of response to stimulus
has_exact_synonym: up-regulation of response to stimulus
has_exact_synonym: upregulation of response to stimulus
has_narrow_synonym: activation of response to stimulus
has_narrow_synonym: stimulation of response to stimulus
has_obo_namespace: biological_process
id: GO:0048584
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

negative regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: response to stimulus
subclass of: negative regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: down regulation of response to stimulus
has_exact_synonym: down-regulation of response to stimulus
has_exact_synonym: downregulation of response to stimulus
has_narrow_synonym: inhibition of response to stimulus
has_obo_namespace: biological_process
id: GO:0048585
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

developmental cell growth
type: Class
subclass of: cell growth
subclass of: Restriction
  on property: part of
  some values from: cellular process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_exact_synonym: developmental growth of a unicellular organism
has_obo_namespace: biological_process
id: GO:0048588
in_subset: gocheck do not annotate

Axiom
annotated source: developmental cell growth
annotated property: definition
annotated target: The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
database_cross_reference: GOC:curators
database_cross_reference: GOC:isa_complete

multicellular organismal reproductive process
type: Class
subclass of: reproductive process
definition: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
has_broad_synonym: organismal reproductive process
database_cross_reference: Reactome:R-HSA-1474165
has_exact_synonym: reproductive process in a multicellular organism
has_obo_namespace: biological_process
id: GO:0048609
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: multicellular organismal reproductive process
annotated property: definition
annotated target: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

Reproduction
type: Axiom
annotated source: multicellular organismal reproductive process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1474165

anatomical structure development
type: Class
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

cell projection morphogenesis
type: Class
subclass of: cell projection organization
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The process in which the anatomical structures of a cell projection are generated and organized.
term tracker item: https://github.com/geneontology/go-ontology/issues/23013
has_obo_namespace: biological_process
id: GO:0048858
in_subset: gocheck do not annotate

Axiom
annotated source: cell projection morphogenesis
annotated property: definition
annotated target: The process in which the anatomical structures of a cell projection are generated and organized.
database_cross_reference: GO_REF:0000021

regulation of biological process
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0050791
has_exact_synonym: regulation of physiological process
has_obo_namespace: biological_process
id: GO:0050789
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: regulation of biological process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:ai
database_cross_reference: GOC:curators

regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: cellular process
definition: Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0051244
has_exact_synonym: regulation of cellular physiological process
has_obo_namespace: biological_process
id: GO:0050794
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of cellular process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:curators

response to stimulus
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
has_alternative_id: GO:0051869
has_exact_synonym: physiological response to stimulus
has_obo_namespace: biological_process
id: GO:0050896
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf

regulation of binding
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
has_obo_namespace: biological_process
id: GO:0051098
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: GOC:ai

positive regulation of binding
type: Class
subclass of: regulation of binding
definition: Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
has_exact_synonym: up regulation of binding
has_exact_synonym: up-regulation of binding
has_exact_synonym: upregulation of binding
has_narrow_synonym: activation of binding
has_narrow_synonym: stimulation of binding
has_obo_namespace: biological_process
id: GO:0051099
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of binding
annotated property: definition
annotated target: Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: GOC:ai

negative regulation of binding
type: Class
subclass of: negative regulation of molecular function
subclass of: regulation of binding
definition: Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
has_exact_synonym: down regulation of binding
has_exact_synonym: down-regulation of binding
has_exact_synonym: downregulation of binding
has_narrow_synonym: inhibition of binding
has_obo_namespace: biological_process
id: GO:0051100
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of binding
annotated property: definition
annotated target: Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: GOC:ai

regulation of DNA binding
type: Class
subclass of: regulation of binding
definition: Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
has_obo_namespace: biological_process
id: GO:0051101
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of DNA binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

regulation of cellular component organization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular component organization
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cellular component organization
definition: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
has_exact_synonym: regulation of cellular component organisation
has_obo_namespace: biological_process
has_related_synonym: regulation of cell organisation
has_related_synonym: regulation of cell organization
has_related_synonym: regulation of cellular component organization and biogenesis
id: GO:0051128
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of cellular component organization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
database_cross_reference: GOC:ai

Axiom
annotated source: regulation of cellular component organization
annotated property: has_related_synonym
annotated target: regulation of cell organisation
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of cellular component organization
annotated property: has_related_synonym
annotated target: regulation of cell organization
database_cross_reference: GOC:mah

Axiom
annotated source: regulation of cellular component organization
annotated property: has_related_synonym
annotated target: regulation of cellular component organization and biogenesis
database_cross_reference: GOC:mah

localization
type: Class
definition: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
term tracker item: https://github.com/geneontology/go-ontology/issues/27052
created by: jl
creation date: 2013-12-18T13:51:04Z
has_alternative_id: GO:1902578
has_exact_synonym: establishment and maintenance of localization
has_exact_synonym: establishment and maintenance of position
has_exact_synonym: localisation
has_narrow_synonym: establishment and maintenance of cellular component location
has_narrow_synonym: establishment and maintenance of substance location
has_narrow_synonym: establishment and maintenance of substrate location
has_obo_namespace: biological_process
has_related_synonym: single organism localization
has_related_synonym: single-organism localization
id: GO:0051179
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: localization
annotated property: definition
annotated target: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dos

Axiom
annotated source: localization
annotated property: has_exact_synonym
annotated target: localisation
database_cross_reference: GOC:mah

Axiom
annotated source: localization
annotated property: has_related_synonym
annotated target: single organism localization
database_cross_reference: GOC:TermGenie

establishment of localization
type: Class
subclass of: localization
definition: Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
term tracker item: https://github.com/geneontology/go-ontology/issues/24200
has_exact_synonym: establishment of localisation
has_obo_namespace: biological_process
id: GO:0051234
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir

Axiom
annotated source: establishment of localization
annotated property: definition
annotated target: Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dos

Axiom
annotated source: establishment of localization
annotated property: has_exact_synonym
annotated target: establishment of localisation
database_cross_reference: GOC:mah

negative regulation of RNA metabolic process
type: Class
subclass of: negative regulation of macromolecule metabolic process
subclass of: negative regulation of nucleobase-containing compound metabolic process
subclass of: Restriction
  on property: regulates
  some values from: nucleic acid metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: nucleic acid metabolic process
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/30771
has_exact_synonym: down regulation of RNA metabolic process
has_exact_synonym: down-regulation of RNA metabolic process
has_exact_synonym: downregulation of RNA metabolic process
has_exact_synonym: negative regulation of RNA metabolism
has_narrow_synonym: inhibition of RNA metabolic process
has_obo_namespace: biological_process
id: GO:0051253
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of RNA metabolic process
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
database_cross_reference: GOC:ai

G1 phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: Wikipedia:G1_phase
has_obo_namespace: biological_process
id: GO:0051318
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: G1 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: GOC:mtg_cell_cycle

G2 phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: Wikipedia:G2_phase
has_obo_namespace: biological_process
id: GO:0051319
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: G2 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: GOC:mtg_cell_cycle

S phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: interphase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: Wikipedia:S_phase
has_exact_synonym: S-phase
has_obo_namespace: biological_process
id: GO:0051320
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: S phase
annotated property: definition
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: GOC:mtg_cell_cycle

anaphase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: M phase
definition: The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle.
database_cross_reference: Wikipedia:Anaphase
has_obo_namespace: biological_process
id: GO:0051322
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: anaphase
annotated property: definition
annotated target: The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle.
database_cross_reference: GOC:mtg_cell_cycle

metaphase
type: Class
subclass of: meiotic cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: M phase
definition: The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
database_cross_reference: Wikipedia:Metaphase
has_obo_namespace: biological_process
id: GO:0051323
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: metaphase
annotated property: definition
annotated target: The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
database_cross_reference: GOC:mtg_cell_cycle

prophase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: M phase
definition: The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: Wikipedia:Prophase
has_obo_namespace: biological_process
id: GO:0051324
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: prophase
annotated property: definition
annotated target: The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: GOC:mtg_cell_cycle

interphase
type: Class
subclass of: cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
has_broad_synonym: resting phase
database_cross_reference: Wikipedia:Interphase
has_exact_synonym: karyostasis
has_obo_namespace: biological_process
id: GO:0051325
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

telophase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: M phase
definition: The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: Wikipedia:Telophase
has_obo_namespace: biological_process
id: GO:0051326
in_subset: gocheck do not annotate
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: telophase
annotated property: definition
annotated target: The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.
database_cross_reference: GOC:mtg_cell_cycle

meiotic M phase
type: Class
subclass of: M phase
subclass of: meiotic cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle.
has_exact_synonym: M phase of meiotic cell cycle
has_obo_namespace: biological_process
id: GO:0051327
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic M phase
annotated property: definition
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

meiotic interphase
type: Class
subclass of: interphase
subclass of: meiotic cell cycle phase
definition: The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA.
has_exact_synonym: interphase of meiotic cell cycle
has_obo_namespace: biological_process
id: GO:0051328
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic interphase
annotated property: definition
annotated target: The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA.
database_cross_reference: GOC:mtg_cell_cycle

mitotic interphase
type: Class
subclass of: interphase
subclass of: mitotic cell cycle phase
definition: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
has_exact_synonym: interphase of mitotic cell cycle
has_obo_namespace: biological_process
id: GO:0051329
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic interphase
annotated property: definition
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
database_cross_reference: GOC:mtg_cell_cycle

meiotic G1 phase
type: Class
subclass of: G1 phase
subclass of: Restriction
  on property: part of
  some values from: meiotic interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.
has_exact_synonym: G1 phase of meiotic cell cycle
has_obo_namespace: biological_process
id: GO:0051330
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic G1 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.
database_cross_reference: GOC:mtg_cell_cycle

meiotic G2 phase
type: Class
subclass of: G2 phase
subclass of: Restriction
  on property: part of
  some values from: meiotic interphase
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.
has_exact_synonym: G2 phase of meiotic cell cycle
has_obo_namespace: biological_process
id: GO:0051331
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic G2 phase
annotated property: definition
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.
database_cross_reference: GOC:mtg_cell_cycle

meiotic S phase
type: Class
subclass of: S phase
subclass of: Restriction
  on property: part of
  some values from: meiotic interphase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.
has_exact_synonym: S phase of meiotic cell cycle
has_exact_synonym: S-phase of meiotic cell cycle
has_exact_synonym: premeiotic S-phase
has_obo_namespace: biological_process
id: GO:0051332
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic S phase
annotated property: definition
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle

organelle localization
type: Class
subclass of: localization
definition: Any process in which an organelle is transported to, and/or maintained in, a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
has_exact_synonym: establishment and maintenance of organelle localization
has_exact_synonym: organelle localisation
has_obo_namespace: biological_process
id: GO:0051640
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: organelle localization
annotated property: definition
annotated target: Any process in which an organelle is transported to, and/or maintained in, a specific location.
database_cross_reference: GOC:ai

Axiom
annotated source: organelle localization
annotated property: has_exact_synonym
annotated target: organelle localisation
database_cross_reference: GOC:mah

cellular localization
type: Class
subclass of: cellular process
subclass of: localization
definition: A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
created by: jl
creation date: 2013-12-18T14:04:32Z
has_alternative_id: GO:1902580
has_exact_synonym: cellular localisation
has_exact_synonym: establishment and maintenance of cellular localization
has_exact_synonym: establishment and maintenance of localization in cell or cell membrane
has_exact_synonym: single organism cellular localization
has_narrow_synonym: intracellular localization
has_narrow_synonym: localization within cell
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular localization
id: GO:0051641
in_subset: gocheck do not annotate
in_subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular localization
annotated property: definition
annotated target: A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

Axiom
annotated source: cellular localization
annotated property: has_exact_synonym
annotated target: cellular localisation
database_cross_reference: GOC:mah

Axiom
annotated source: cellular localization
annotated property: has_exact_synonym
annotated target: single organism cellular localization
database_cross_reference: GOC:TermGenie

biological process involved in intraspecies interaction between organisms
type: Class
definition: Any process in which an organism has an effect on an organism of the same species.
term tracker item: https://github.com/geneontology/go-ontology/issues/20191
has_exact_synonym: intraspecies interaction between organisms
has_exact_synonym: intraspecies interaction with other organisms
has_obo_namespace: biological_process
id: GO:0051703
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: biological process involved in intraspecies interaction between organisms
annotated property: definition
annotated target: Any process in which an organism has an effect on an organism of the same species.
database_cross_reference: GOC:ai

cellular response to stimulus
type: Class
subclass of: cellular process
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
database_cross_reference: Reactome:R-HSA-8953897
has_obo_namespace: biological_process
id: GO:0051716
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

Cellular responses to stimuli
type: Axiom
annotated source: cellular response to stimulus
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8953897

molecular transducer activity
type: Class
definition: A compound molecular function in which an effector function is controlled by one or more regulatory components.
has_obo_namespace: molecular_function
id: GO:0060089
in_subset: gocheck do not annotate
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: molecular transducer activity
annotated property: definition
annotated target: A compound molecular function in which an effector function is controlled by one or more regulatory components.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pdt

estrous cycle phase
type: Class
subclass of: biological phase
definition: The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur.
has_obo_namespace: biological_process
id: GO:0060206
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: estrous cycle phase
annotated property: definition
annotated target: The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur.
database_cross_reference: GOC:dph

diestrus
type: Class
subclass of: estrous cycle phase
definition: The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum.
has_obo_namespace: biological_process
id: GO:0060207
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: diestrus
annotated property: definition
annotated target: The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum.
database_cross_reference: GOC:dph
database_cross_reference: ISBN:0721662544

proestrus
type: Class
subclass of: estrous cycle phase
definition: The estrous cycle phase in which there is heightened follicular activity.
has_obo_namespace: biological_process
id: GO:0060208
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: proestrus
annotated property: definition
annotated target: The estrous cycle phase in which there is heightened follicular activity.
database_cross_reference: GOC:dph
database_cross_reference: ISBN:0721662544

estrus
type: Class
subclass of: estrous cycle phase
definition: The estrous cycle phase in which a female is sexually receptive.
has_exact_synonym: oestrus
has_obo_namespace: biological_process
id: GO:0060209
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: estrus
annotated property: definition
annotated target: The estrous cycle phase in which a female is sexually receptive.
database_cross_reference: GOC:dph
database_cross_reference: ISBN:0721662544

metestrus
type: Class
subclass of: estrous cycle phase
definition: The estrous cycle phase in which there is subsiding follicular function.
has_obo_namespace: biological_process
id: GO:0060210
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: metestrus
annotated property: definition
annotated target: The estrous cycle phase in which there is subsiding follicular function.
database_cross_reference: GOC:dph
database_cross_reference: ISBN:0721662544

regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: macromolecule metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
term tracker item: https://github.com/geneontology/go-ontology/issues/31032
has_obo_namespace: biological_process
id: GO:0060255
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of macromolecule metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

myeloid leukocyte cytokine production
type: Class
subclass of: cytokine production involved in immune response
definition: Any process that contributes to cytokine production by a myeloid cell.
created by: dph
creation date: 2010-04-13T11:29:42Z
has_obo_namespace: biological_process
id: GO:0061082
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: myeloid leukocyte cytokine production
annotated property: definition
annotated target: Any process that contributes to cytokine production by a myeloid cell.
database_cross_reference: GOC:dph

process utilizing autophagic mechanism
type: Class
subclass of: cellular process
definition: A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway.
created by: dph
creation date: 2017-07-13T19:42:14Z
has_obo_namespace: biological_process
id: GO:0061919
in_subset: gocheck do not annotate

Axiom
annotated source: process utilizing autophagic mechanism
annotated property: definition
annotated target: A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway.
database_cross_reference: PMID:21997368
database_cross_reference: PMID:22966490
database_cross_reference: PMID:28596378

regulation of small molecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: small molecule metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: small molecule metabolic process
definition: Any process that modulates the rate, frequency or extent of a small molecule metabolic process.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: dph
creation date: 2018-03-19T14:11:54Z
database_cross_reference: Reactome:R-HSA-9861718
has_exact_synonym: regulation of small molecule metabolism
has_obo_namespace: biological_process
id: GO:0062012
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of small molecule metabolic process
annotated property: definition
annotated target: Any process that modulates the rate, frequency or extent of a small molecule metabolic process.
database_cross_reference: GOC:vw

Regulation of pyruvate metabolism
type: Axiom
annotated source: regulation of small molecule metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9861718

positive regulation of small molecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: small molecule metabolic process
subclass of: positive regulation of metabolic process
subclass of: regulation of small molecule metabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: small molecule metabolic process
definition: Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: dph
creation date: 2018-03-19T14:25:10Z
has_exact_synonym: positive regulation of small molecule metabolism
has_obo_namespace: biological_process
id: GO:0062013
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of small molecule metabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.
database_cross_reference: GOC:vw

negative regulation of small molecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: small molecule metabolic process
subclass of: negative regulation of metabolic process
subclass of: regulation of small molecule metabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: small molecule metabolic process
definition: Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: dph
creation date: 2018-03-19T14:27:23Z
has_exact_synonym: negative regulation of small molecule metabolism
has_obo_namespace: biological_process
id: GO:0062014
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of small molecule metabolic process
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.
database_cross_reference: GOC:vw

biofilm matrix
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: cellular anatomical structure
definition: A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules.
term tracker item: https://github.com/geneontology/go-ontology/issues/22176
created by: dph
creation date: 2018-05-04T12:49:17Z
database_cross_reference: PMID:28955324
has_obo_namespace: cellular_component
id: GO:0062039
in_subset: gocheck do not annotate

Axiom
annotated source: biofilm matrix
annotated property: definition
annotated target: A type of extracellular matrix that surrounds the cells within a microbial biofilm. The matrix is composed of extracellular polymeric substances including exopolysaccharides, proteins, nucleic acids, lipids, and other biomolecules.
database_cross_reference: PMID:22571672
database_cross_reference: PMID:27129222
database_cross_reference: PMID:28516088
database_cross_reference: PMID:32663461

biological regulation
type: Class
definition: Any process that modulates a measurable attribute of any biological process, quality or function.
has_broad_synonym: regulation
has_obo_namespace: biological_process
id: GO:0065007
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: biological regulation
annotated property: definition
annotated target: Any process that modulates a measurable attribute of any biological process, quality or function.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: GOC:vw

regulation of biological quality
type: Class
subclass of: biological regulation
definition: Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
term tracker item: https://github.com/geneontology/go-ontology/issues/30599
has_exact_synonym: regulation of biological attribute
has_exact_synonym: regulation of biological characteristic
has_obo_namespace: biological_process
id: GO:0065008
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: regulation of biological quality
annotated property: definition
annotated target: Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: GOC:vw

SWI/SNF superfamily-type complex
type: Class
subclass of: nuclear protein-containing complex
subclass of: Restriction
  on property: part of
  some values from: intracellular membraneless organelle
definition: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.
created by: mah
creation date: 2009-04-29T12:55:46Z
has_alternative_id: GO:0090544
has_exact_synonym: BAF-type complex
has_exact_synonym: SWI-SNF-type complex
has_obo_namespace: cellular_component
has_related_synonym: SWI-SNF global transcription activator complex
has_related_synonym: SWI/SNF-type complex
has_related_synonym: SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex
id: GO:0070603
in_subset: gocheck do not annotate

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: definition
annotated target: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.
database_cross_reference: GOC:bhm
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah
database_cross_reference: PMID:16155938

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_exact_synonym
annotated target: SWI-SNF-type complex
database_cross_reference: GOC:mah

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI-SNF global transcription activator complex
database_cross_reference: CORUM:224

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI/SNF-type complex
database_cross_reference: GOC:krc

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex
database_cross_reference: GOC:krc

interleukin-35 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2009-06-23T01:25:11Z
has_alternative_id: GO:0070749
has_alternative_id: GO:0072626
has_exact_synonym: IL-35 production
has_narrow_synonym: interleukin-35 biosynthetic process
has_narrow_synonym: interleukin-35 secretion
has_obo_namespace: biological_process
id: GO:0070753
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-35 production
annotated property: definition
annotated target: The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah

Axiom
annotated source: interleukin-35 production
annotated property: has_exact_synonym
annotated target: IL-35 production
database_cross_reference: GOC:add

cellular response to chemical stimulus
type: Class
subclass of: response to chemical
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
created by: mah
creation date: 2009-08-27T04:41:45Z
has_obo_namespace: biological_process
id: GO:0070887
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to chemical stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:mah

regulatory ncRNA processing
type: Class
subclass of: primary metabolic process
subclass of: Restriction
  on property: part of
  some values from: negative regulation of macromolecule biosynthetic process
subclass of: Restriction
  on property: part of
  some values from: RNA biosynthetic process
definition: A process leading to the generation of a functional regulatory non-coding RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/19303
term tracker item: https://github.com/geneontology/go-ontology/issues/23081
term tracker item: https://github.com/geneontology/go-ontology/issues/24199
created by: mah
creation date: 2009-09-11T03:32:19Z
has_alternative_id: GO:0031051
has_narrow_synonym: gene silencing by RNA, production of guide RNA
has_narrow_synonym: gene silencing by RNA, production of small RNA
has_narrow_synonym: primary sncRNA processing
has_narrow_synonym: production of small RNA involved in gene silencing by RNA
has_narrow_synonym: small regulatory ncRNA maturation
has_narrow_synonym: small regulatory ncRNA processing
has_narrow_synonym: sncRNA processing
has_narrow_synonym: sncRNA production
has_obo_namespace: biological_process
id: GO:0070918
in_subset: gocheck do not annotate

Axiom
annotated source: regulatory ncRNA processing
annotated property: definition
annotated target: A process leading to the generation of a functional regulatory non-coding RNA.
database_cross_reference: GOC:mah
database_cross_reference: PMID:15196465
database_cross_reference: PMID:19239886

Axiom
annotated source: regulatory ncRNA processing
annotated property: has_narrow_synonym
annotated target: gene silencing by RNA, production of guide RNA
database_cross_reference: GOC:mah

Axiom
annotated source: regulatory ncRNA processing
annotated property: has_narrow_synonym
annotated target: gene silencing by RNA, production of small RNA
database_cross_reference: GOC:mah

organelle assembly
type: Class
subclass of: organelle organization
subclass of: cellular component assembly
definition: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
created by: mah
creation date: 2009-09-15T03:00:51Z
has_obo_namespace: biological_process
id: GO:0070925
in_subset: gocheck do not annotate
in_subset: goslim yeast

Axiom
annotated source: organelle assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah

spindle assembly checkpoint signaling
type: Class
subclass of: spindle checkpoint signaling
definition: A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
created by: mah
creation date: 2009-11-23T12:36:57Z
has_alternative_id: GO:0072486
has_broad_synonym: SAC
has_exact_synonym: signal transduction involved in spindle assembly checkpoint
has_exact_synonym: spindle assembly checkpoint
has_obo_namespace: biological_process
id: GO:0071173
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).

Axiom
annotated source: spindle assembly checkpoint signaling
annotated property: definition
annotated target: A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
database_cross_reference: GOC:mah

Axiom
annotated source: spindle assembly checkpoint signaling
annotated property: has_broad_synonym
annotated target: SAC
database_cross_reference: GOC:mah

mitotic spindle checkpoint signaling
type: Class
subclass of: mitotic cell cycle checkpoint signaling
subclass of: spindle checkpoint signaling
definition: A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
created by: mah
creation date: 2009-11-23T12:41:36Z
has_alternative_id: GO:0072477
has_exact_synonym: mitotic cell cycle spindle checkpoint
has_exact_synonym: mitotic spindle checkpoint
has_exact_synonym: signal transduction involved in mitotic cell cycle spindle checkpoint
has_exact_synonym: signal transduction involved in mitotic spindle checkpoint
has_obo_namespace: biological_process
has_related_synonym: topo II checkpoint
has_related_synonym: topoisomerase II checkpoint
id: GO:0071174
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints).

Axiom
annotated source: mitotic spindle checkpoint signaling
annotated property: definition
annotated target: A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.
database_cross_reference: GOC:mtg_cell_cycle

cellular response to abiotic stimulus
type: Class
subclass of: response to abiotic stimulus
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.
created by: mah
creation date: 2009-12-03T01:02:11Z
has_narrow_synonym: cellular response to abiotic stress
has_obo_namespace: biological_process
id: GO:0071214
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to abiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular response to abiotic stimulus
annotated property: has_narrow_synonym
annotated target: cellular response to abiotic stress
database_cross_reference: GOC:mah

cellular response to biotic stimulus
type: Class
subclass of: response to biotic stimulus
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
created by: mah
creation date: 2009-12-03T01:09:08Z
has_narrow_synonym: cellular response to biotic stress
has_obo_namespace: biological_process
id: GO:0071216
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular response to biotic stimulus
annotated property: has_narrow_synonym
annotated target: cellular response to biotic stress
database_cross_reference: GOC:mah

cellular response to acid chemical
type: Class
subclass of: response to acid chemical
subclass of: cellular response to chemical stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
created by: mah
creation date: 2009-12-03T02:07:23Z
has_broad_synonym: cellular response to acid
has_obo_namespace: biological_process
has_related_synonym: cellular response to acid anion
has_related_synonym: cellular response to oxoanion
id: GO:0071229
in_subset: gocheck do not annotate
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.

Axiom
annotated source: cellular response to acid chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
database_cross_reference: GOC:curators
database_cross_reference: GOC:mah
database_cross_reference: Wikipedia:Acid

cellular response to fluoxetine
type: Class
subclass of: response to fluoxetine
subclass of: cellular response to chemical stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
created by: mah
creation date: 2009-12-14T03:09:58Z
has_obo_namespace: biological_process
id: GO:0071411
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to fluoxetine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr

cellular response to endogenous stimulus
type: Class
subclass of: response to endogenous stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
created by: mah
creation date: 2009-12-18T02:25:40Z
database_cross_reference: Reactome:R-HSA-9860931
has_obo_namespace: biological_process
id: GO:0071495
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to endogenous stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
database_cross_reference: GOC:mah

Response of endothelial cells to shear stress
type: Axiom
annotated source: cellular response to endogenous stimulus
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9860931

cellular response to external stimulus
type: Class
subclass of: response to external stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
created by: mah
creation date: 2009-12-18T02:36:52Z
has_obo_namespace: biological_process
id: GO:0071496
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:mah

monocyte chemotactic protein-1 production
type: Class
subclass of: chemokine production
definition: The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:09:53Z
has_exact_synonym: CCL2 production
has_exact_synonym: MCP-1 production
has_obo_namespace: biological_process
id: GO:0071605
in_subset: gocheck do not annotate

Axiom
annotated source: monocyte chemotactic protein-1 production
annotated property: definition
annotated target: The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: monocyte chemotactic protein-1 production
annotated property: has_exact_synonym
annotated target: CCL2 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: monocyte chemotactic protein-1 production
annotated property: has_exact_synonym
annotated target: MCP-1 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

chemokine (C-C motif) ligand 4 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:16:42Z
has_broad_synonym: macrophage inflammatory protein production
has_exact_synonym: CCL4 production
has_exact_synonym: MIP-1b production
has_obo_namespace: biological_process
id: GO:0071606
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 4 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 4 production
annotated property: has_broad_synonym
annotated target: macrophage inflammatory protein production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 4 production
annotated property: has_exact_synonym
annotated target: CCL4 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 4 production
annotated property: has_exact_synonym
annotated target: MIP-1b production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

macrophage inflammatory protein-1 gamma production
type: Class
subclass of: chemokine production
definition: The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:19:52Z
has_exact_synonym: CCL9 production
has_exact_synonym: MIP-1g production
has_exact_synonym: chemokine (C-C motif) ligand 9 production
has_obo_namespace: biological_process
id: GO:0071607
in_subset: gocheck do not annotate

Axiom
annotated source: macrophage inflammatory protein-1 gamma production
annotated property: definition
annotated target: The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 gamma production
annotated property: has_exact_synonym
annotated target: CCL9 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 gamma production
annotated property: has_exact_synonym
annotated target: MIP-1g production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 gamma production
annotated property: has_exact_synonym
annotated target: chemokine (C-C motif) ligand 9 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

macrophage inflammatory protein-1 alpha production
type: Class
subclass of: chemokine production
definition: The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:24:17Z
has_broad_synonym: macrophage inflammatory protein production
has_exact_synonym: CCL3 production
has_exact_synonym: MIP-1a production
has_exact_synonym: chemokine (C-C motif) ligand 3 production
has_obo_namespace: biological_process
id: GO:0071608
in_subset: gocheck do not annotate

Axiom
annotated source: macrophage inflammatory protein-1 alpha production
annotated property: definition
annotated target: The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 alpha production
annotated property: has_broad_synonym
annotated target: macrophage inflammatory protein production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 alpha production
annotated property: has_exact_synonym
annotated target: CCL3 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 alpha production
annotated property: has_exact_synonym
annotated target: MIP-1a production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: macrophage inflammatory protein-1 alpha production
annotated property: has_exact_synonym
annotated target: chemokine (C-C motif) ligand 3 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

chemokine (C-C motif) ligand 5 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:32:35Z
has_exact_synonym: CCL5 production
has_exact_synonym: RANTES production
has_exact_synonym: Regulated upon Activation, Normal T-cell Expressed, and Secreted production
has_obo_namespace: biological_process
id: GO:0071609
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 5 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 5 production
annotated property: has_exact_synonym
annotated target: CCL5 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 5 production
annotated property: has_exact_synonym
annotated target: RANTES production
database_cross_reference: GOC:bf

Axiom
annotated source: chemokine (C-C motif) ligand 5 production
annotated property: has_exact_synonym
annotated target: Regulated upon Activation, Normal T-cell Expressed, and Secreted production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

chemokine (C-C motif) ligand 1 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:35:00Z
has_exact_synonym: CCL1 production
has_exact_synonym: T cell activation 3 production
has_exact_synonym: TCA-3 production
has_obo_namespace: biological_process
id: GO:0071610
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 1 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: CCL1 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: T cell activation 3 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: chemokine (C-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: TCA-3 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

granulocyte colony-stimulating factor production
type: Class
subclass of: cytokine production
definition: The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:38:11Z
has_exact_synonym: CSF3 production
has_exact_synonym: G-CSF production
has_exact_synonym: colony stimulating factor 3 (granulocyte) production
has_exact_synonym: filgrastim production
has_exact_synonym: granulocyte colony stimulating factor production
has_exact_synonym: lenograstim production
has_exact_synonym: pluripoietin production
has_obo_namespace: biological_process
id: GO:0071611
in_subset: gocheck do not annotate

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: definition
annotated target: The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: CSF3 production
database_cross_reference: GOC:add

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: G-CSF production
database_cross_reference: GOC:add

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: colony stimulating factor 3 (granulocyte) production
database_cross_reference: GOC:add

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: filgrastim production
database_cross_reference: GOC:add

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: lenograstim production
database_cross_reference: GOC:add

Axiom
annotated source: granulocyte colony-stimulating factor production
annotated property: has_exact_synonym
annotated target: pluripoietin production
database_cross_reference: GOC:add

IP-10 production
type: Class
subclass of: chemokine production
definition: The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:43:56Z
has_exact_synonym: CXCL10 production
has_exact_synonym: chemokine (C-C motif) ligand 10 production
has_obo_namespace: biological_process
id: GO:0071612
in_subset: gocheck do not annotate

Axiom
annotated source: IP-10 production
annotated property: definition
annotated target: The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: IP-10 production
annotated property: has_exact_synonym
annotated target: CXCL10 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

Axiom
annotated source: IP-10 production
annotated property: has_exact_synonym
annotated target: chemokine (C-C motif) ligand 10 production
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

granzyme B production
type: Class
subclass of: production of molecular mediator of immune response
definition: The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-02-05T04:47:15Z
has_obo_namespace: biological_process
id: GO:0071613
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: granzyme B production
annotated property: definition
annotated target: The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add
database_cross_reference: GOC:rv

tumor necrosis factor superfamily cytokine production
type: Class
subclass of: cytokine production
definition: The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-03-09T02:40:35Z
has_exact_synonym: TNFSF cytokine production
has_obo_namespace: biological_process
has_related_synonym: TNF superfamily production
id: GO:0071706
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: tumor necrosis factor superfamily cytokine production
annotated property: definition
annotated target: The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:add

Axiom
annotated source: tumor necrosis factor superfamily cytokine production
annotated property: has_exact_synonym
annotated target: TNFSF cytokine production
database_cross_reference: GOC:add

Axiom
annotated source: tumor necrosis factor superfamily cytokine production
annotated property: has_related_synonym
annotated target: TNF superfamily production
database_cross_reference: GOC:rv

cellular component organization or biogenesis
type: Class
subclass of: cellular process
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
term tracker item: https://github.com/geneontology/go-ontology/issues/27189
created by: mah
creation date: 2010-09-10T01:39:16Z
has_alternative_id: GO:0071841
has_exact_synonym: cellular component organisation or biogenesis
has_exact_synonym: cellular component organisation or biogenesis at cellular level
has_exact_synonym: cellular component organization or biogenesis at cellular level
has_obo_namespace: biological_process
id: GO:0071840
in_subset: gocheck do not annotate
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular component organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular component organisation or biogenesis at cellular level
database_cross_reference: GOC:mah

chemokine (C-C motif) ligand 22 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-09-28T11:33:13Z
has_exact_synonym: C-C motif chemokine 22 production
has_exact_synonym: CCL-22 production
has_exact_synonym: CCL22 production
has_obo_namespace: biological_process
id: GO:0071924
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 22 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:18832724

Axiom
annotated source: chemokine (C-C motif) ligand 22 production
annotated property: has_exact_synonym
annotated target: C-C motif chemokine 22 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 22 production
annotated property: has_exact_synonym
annotated target: CCL-22 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 22 production
annotated property: has_exact_synonym
annotated target: CCL22 production
database_cross_reference: GOC:mah

thymic stromal lymphopoietin production
type: Class
subclass of: chemokine production
definition: The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-09-28T11:38:55Z
has_exact_synonym: TSLP production
has_obo_namespace: biological_process
id: GO:0071925
in_subset: gocheck do not annotate

Axiom
annotated source: thymic stromal lymphopoietin production
annotated property: definition
annotated target: The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:17129180

Axiom
annotated source: thymic stromal lymphopoietin production
annotated property: has_exact_synonym
annotated target: TSLP production
database_cross_reference: GOC:mah

nitrogen cycle metabolic process
type: Class
subclass of: metabolic process
definition: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
created by: mah
creation date: 2010-09-30T05:21:03Z
database_cross_reference: Wikipedia:Nitrogen_cycle
has_obo_namespace: biological_process
id: GO:0071941
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: nitrogen cycle metabolic process
annotated property: definition
annotated target: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16675690
database_cross_reference: Wikipedia:Nitrogen_cycle

chemokine (C-C motif) ligand 11 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2010-10-08T12:10:34Z
has_broad_synonym: eotaxin production
has_exact_synonym: C-C motif chemokine 11 production
has_exact_synonym: CCL-11 production
has_exact_synonym: CCL11 production
has_exact_synonym: eotaxin-1 production
has_obo_namespace: biological_process
id: GO:0071954
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:mah
database_cross_reference: PMID:9600955

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: has_broad_synonym
annotated target: eotaxin production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: has_exact_synonym
annotated target: C-C motif chemokine 11 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: has_exact_synonym
annotated target: CCL-11 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: has_exact_synonym
annotated target: CCL11 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-C motif) ligand 11 production
annotated property: has_exact_synonym
annotated target: eotaxin-1 production
database_cross_reference: GOC:mah

renal system development
type: Class
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: multicellular organism development
definition: The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.
created by: mah
creation date: 2010-01-25T10:31:00Z
has_broad_synonym: urinary system development
has_broad_synonym: urinary tract development
has_obo_namespace: biological_process
id: GO:0072001
in_subset: gocheck do not annotate

Axiom
annotated source: renal system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.
database_cross_reference: GOC:mtg_kidney_jan10
database_cross_reference: GOC:yaf
database_cross_reference: PMID:6996269

Axiom
annotated source: renal system development
annotated property: has_broad_synonym
annotated target: urinary system development
database_cross_reference: GOC:yaf

Axiom
annotated source: renal system development
annotated property: has_broad_synonym
annotated target: urinary tract development
database_cross_reference: GOC:yaf
database_cross_reference: PMID:17881463

renal system pattern specification
type: Class
subclass of: multicellular organismal process
subclass of: Restriction
  on property: part of
  some values from: renal system development
definition: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system.
created by: mah
creation date: 2010-01-25T03:31:51Z
has_obo_namespace: biological_process
has_related_synonym: renal system pattern formation
id: GO:0072048
in_subset: gocheck do not annotate

Axiom
annotated source: renal system pattern specification
annotated property: definition
annotated target: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system.
database_cross_reference: GOC:mtg_kidney_jan10

Axiom
annotated source: renal system pattern specification
annotated property: has_related_synonym
annotated target: renal system pattern formation
database_cross_reference: GOC:mtg_kidney_jan10

modified amino acid transport
type: Class
subclass of: transport
definition: The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
created by: mah
creation date: 2010-11-04T12:18:23Z
has_exact_synonym: amino acid derivative transport
has_obo_namespace: biological_process
id: GO:0072337
in_subset: gocheck do not annotate

Axiom
annotated source: modified amino acid transport
annotated property: definition
annotated target: The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:mah

tumor necrosis factor (ligand) superfamily member 11 production
type: Class
subclass of: tumor necrosis factor superfamily cytokine production
definition: The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2011-01-14T01:42:23Z
has_exact_synonym: RANKL production
has_exact_synonym: TNFSF11 production
has_exact_synonym: tumor necrosis factor ligand superfamily member 11 production
has_obo_namespace: biological_process
id: GO:0072535
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: tumor necrosis factor (ligand) superfamily member 11 production
annotated property: definition
annotated target: The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah

Axiom
annotated source: tumor necrosis factor (ligand) superfamily member 11 production
annotated property: has_exact_synonym
annotated target: RANKL production
database_cross_reference: GOC:ebc
database_cross_reference: PR:000002107

Axiom
annotated source: tumor necrosis factor (ligand) superfamily member 11 production
annotated property: has_exact_synonym
annotated target: TNFSF11 production
database_cross_reference: GOC:mah
database_cross_reference: PR:000002107

Axiom
annotated source: tumor necrosis factor (ligand) superfamily member 11 production
annotated property: has_exact_synonym
annotated target: tumor necrosis factor ligand superfamily member 11 production
database_cross_reference: GOC:bf
database_cross_reference: PR:000002107

chemokine (C-X-C motif) ligand 1 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2011-01-31T11:31:58Z
has_exact_synonym: CXCL1 production
has_exact_synonym: KC production
has_exact_synonym: SCYB1 production
has_exact_synonym: keratinocyte derived chemokine production
has_obo_namespace: biological_process
id: GO:0072566
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 1 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-X-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: CXCL1 production
database_cross_reference: GOC:BHF

Axiom
annotated source: chemokine (C-X-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: KC production
database_cross_reference: GOC:BHF

Axiom
annotated source: chemokine (C-X-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: SCYB1 production
database_cross_reference: GOC:BHF

Axiom
annotated source: chemokine (C-X-C motif) ligand 1 production
annotated property: has_exact_synonym
annotated target: keratinocyte derived chemokine production
database_cross_reference: GOC:BHF

chemokine (C-X-C motif) ligand 2 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: mah
creation date: 2011-01-31T11:33:40Z
has_exact_synonym: CXCL2 production
has_exact_synonym: MIP-2 production
has_exact_synonym: MIP2 production
has_exact_synonym: SCYB2 production
has_obo_namespace: biological_process
id: GO:0072567
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 2 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-X-C motif) ligand 2 production
annotated property: has_exact_synonym
annotated target: CXCL2 production
database_cross_reference: GOC:mah

Axiom
annotated source: chemokine (C-X-C motif) ligand 2 production
annotated property: has_exact_synonym
annotated target: MIP-2 production
database_cross_reference: GOC:BHF

Axiom
annotated source: chemokine (C-X-C motif) ligand 2 production
annotated property: has_exact_synonym
annotated target: MIP2 production
database_cross_reference: GOC:BHF

Axiom
annotated source: chemokine (C-X-C motif) ligand 2 production
annotated property: has_exact_synonym
annotated target: SCYB2 production
database_cross_reference: GOC:BHF

interleukin-28A production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072628
has_exact_synonym: IL-28A production
has_exact_synonym: IL28A production
has_exact_synonym: interferon lambda 2 production
has_narrow_synonym: interleukin-28A secretion
has_obo_namespace: biological_process
id: GO:0072627
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interleukin-28A production
annotated property: definition
annotated target: The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interleukin-28A production
annotated property: has_exact_synonym
annotated target: IL-28A production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-28A production
annotated property: has_exact_synonym
annotated target: IL28A production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-28A production
annotated property: has_exact_synonym
annotated target: interferon lambda 2 production
database_cross_reference: GOC:BHF

interleukin-28B production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072630
has_exact_synonym: IL-28B production
has_exact_synonym: IL28B production
has_exact_synonym: interferon lambda 3 production
has_narrow_synonym: interleukin-28B secretion
has_obo_namespace: biological_process
id: GO:0072629
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interleukin-28B production
annotated property: definition
annotated target: The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interleukin-28B production
annotated property: has_exact_synonym
annotated target: IL-28B production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-28B production
annotated property: has_exact_synonym
annotated target: IL28B production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-28B production
annotated property: has_exact_synonym
annotated target: interferon lambda 3 production
database_cross_reference: GOC:BHF

interleukin-29 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072632
has_exact_synonym: IL-29 production
has_exact_synonym: IL29 production
has_exact_synonym: interferon lambda 1 production
has_narrow_synonym: interleukin-29 secretion
has_obo_namespace: biological_process
id: GO:0072631
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interleukin-29 production
annotated property: definition
annotated target: The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interleukin-29 production
annotated property: has_exact_synonym
annotated target: IL-29 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-29 production
annotated property: has_exact_synonym
annotated target: IL29 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-29 production
annotated property: has_exact_synonym
annotated target: interferon lambda 1 production
database_cross_reference: GOC:BHF

interleukin-30 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072634
has_exact_synonym: IL-30 production
has_exact_synonym: interleukin-30 complex production
has_narrow_synonym: interleukin-30 secretion
has_obo_namespace: biological_process
id: GO:0072633
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-30 production
annotated property: definition
annotated target: The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:30328794

Axiom
annotated source: interleukin-30 production
annotated property: has_exact_synonym
annotated target: IL-30 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-30 production
annotated property: has_exact_synonym
annotated target: interleukin-30 complex production
database_cross_reference: GOC:BHF

interleukin-31 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072636
has_exact_synonym: IL-31 production
has_narrow_synonym: interleukin-31 secretion
has_obo_namespace: biological_process
id: GO:0072635
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-31 production
annotated property: definition
annotated target: The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:30328794

Axiom
annotated source: interleukin-31 production
annotated property: has_exact_synonym
annotated target: IL-31 production
database_cross_reference: GOC:BHF

interleukin-32 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bc
creation date: 2020-02-21T10:26:40Z
has_alternative_id: GO:0072638
has_alternative_id: GO:0150188
has_exact_synonym: IL-32 production
has_exact_synonym: IL32 production
has_narrow_synonym: NK4 production
has_narrow_synonym: TAIF production
has_narrow_synonym: interleukin-32 biosynthetic process
has_narrow_synonym: interleukin-32 secretion
has_obo_namespace: biological_process
id: GO:0072637
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-32 production
annotated property: definition
annotated target: The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:23729669

Axiom
annotated source: interleukin-32 production
annotated property: has_exact_synonym
annotated target: IL-32 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-32 production
annotated property: has_exact_synonym
annotated target: IL32 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-32 production
annotated property: has_narrow_synonym
annotated target: NK4 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-32 production
annotated property: has_narrow_synonym
annotated target: TAIF production
database_cross_reference: GOC:BHF

interleukin-33 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072640
has_alternative_id: GO:0150126
has_exact_synonym: IL-33 production
has_exact_synonym: IL33 production
has_exact_synonym: NF-HEV production
has_narrow_synonym: C9orf26 production
has_narrow_synonym: IL1F11 production
has_narrow_synonym: interleukin-33 biosynthetic process
has_narrow_synonym: interleukin-33 secretion
has_obo_namespace: biological_process
id: GO:0072639
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-33 production
annotated property: definition
annotated target: The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:29778524

Axiom
annotated source: interleukin-33 production
annotated property: has_exact_synonym
annotated target: IL-33 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-33 production
annotated property: has_exact_synonym
annotated target: IL33 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-33 production
annotated property: has_exact_synonym
annotated target: NF-HEV production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-33 production
annotated property: has_narrow_synonym
annotated target: C9orf26 production
database_cross_reference: GOC:BHF

Axiom
annotated source: interleukin-33 production
annotated property: has_narrow_synonym
annotated target: IL1F11 production
database_cross_reference: GOC:BHF

interferon-delta production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072646
has_exact_synonym: IFN-delta production
has_exact_synonym: IFND production
has_narrow_synonym: interferon-delta secretion
has_obo_namespace: biological_process
id: GO:0072645
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-delta production
annotated property: definition
annotated target: The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-delta production
annotated property: has_exact_synonym
annotated target: IFN-delta production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-delta production
annotated property: has_exact_synonym
annotated target: IFND production
database_cross_reference: GOC:BHF

interferon-epsilon production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072648
has_exact_synonym: IFN-epsilon production
has_exact_synonym: IFNE production
has_narrow_synonym: interferon-epsilon secretion
has_obo_namespace: biological_process
id: GO:0072647
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-epsilon production
annotated property: definition
annotated target: The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-epsilon production
annotated property: has_exact_synonym
annotated target: IFN-epsilon production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-epsilon production
annotated property: has_exact_synonym
annotated target: IFNE production
database_cross_reference: GOC:BHF

interferon-kappa production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072650
has_exact_synonym: IFN-kappa production
has_exact_synonym: IFNK production
has_narrow_synonym: interferon-kappa secretion
has_obo_namespace: biological_process
id: GO:0072649
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-kappa production
annotated property: definition
annotated target: The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-kappa production
annotated property: has_exact_synonym
annotated target: IFN-kappa production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-kappa production
annotated property: has_exact_synonym
annotated target: IFNK production
database_cross_reference: GOC:BHF

interferon-tau production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072652
has_exact_synonym: IFN-tau production
has_exact_synonym: IFN-tau secretion
has_exact_synonym: IFNT production
has_narrow_synonym: interferon-tau secretion
has_obo_namespace: biological_process
id: GO:0072651
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-tau production
annotated property: definition
annotated target: The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-tau production
annotated property: has_exact_synonym
annotated target: IFN-tau production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-tau production
annotated property: has_exact_synonym
annotated target: IFN-tau secretion
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-tau production
annotated property: has_exact_synonym
annotated target: IFNT production
database_cross_reference: GOC:BHF

interferon-omega production
type: Class
subclass of: type I interferon production
definition: The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_alternative_id: GO:0072654
has_exact_synonym: IFN-omega production
has_exact_synonym: IFNW production
has_narrow_synonym: interferon-omega secretion
has_obo_namespace: biological_process
id: GO:0072653
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: interferon-omega production
annotated property: definition
annotated target: The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: PMID:15546383

Axiom
annotated source: interferon-omega production
annotated property: has_exact_synonym
annotated target: IFN-omega production
database_cross_reference: GOC:mah

Axiom
annotated source: interferon-omega production
annotated property: has_exact_synonym
annotated target: IFNW production
database_cross_reference: GOC:BHF

single-celled organism vegetative growth phase
type: Class
subclass of: biological phase
definition: A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods.
term tracker item: https://github.com/geneontology/go-ontology/issues/18275
created by: mah
creation date: 2011-08-19T12:05:19Z
has_alternative_id: GO:0062178
has_exact_synonym: vegetative growth of a single-celled organism
has_narrow_synonym: stationary phase
has_obo_namespace: biological_process
id: GO:0072690
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: single-celled organism vegetative growth phase
annotated property: definition
annotated target: A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods.
database_cross_reference: GOC:mah
database_cross_reference: GOV:vw

regulation of primary metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: primary metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: primary metabolic process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/31498
created by: dhl
creation date: 2009-04-22T04:30:52Z
has_obo_namespace: biological_process
id: GO:0080090
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of primary metabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
database_cross_reference: PMID:19211694

regulation of response to stress
type: Class
subclass of: regulation of response to stimulus
definition: Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
created by: dhl
creation date: 2009-05-06T04:51:28Z
has_obo_namespace: biological_process
id: GO:0080134
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to stress
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:dhl

regulation of spindle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: spindle checkpoint signaling
subclass of: regulation of cell cycle checkpoint
subclass of: Restriction
  on property: regulates
  some values from: spindle checkpoint signaling
definition: Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_obo_namespace: biological_process
id: GO:0090231
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of spindle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: spindle checkpoint signaling
subclass of: positive regulation of cellular process
subclass of: positive regulation of response to stimulus
subclass of: regulation of spindle checkpoint
subclass of: Restriction
  on property: positively regulates
  some values from: spindle checkpoint signaling
definition: Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_narrow_synonym: spindle checkpoint activation
has_obo_namespace: biological_process
id: GO:0090232
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of spindle checkpoint
annotated property: has_narrow_synonym
annotated target: spindle checkpoint activation
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of spindle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: spindle checkpoint signaling
subclass of: regulation of spindle checkpoint
subclass of: negative regulation of cell cycle checkpoint
subclass of: Restriction
  on property: negatively regulates
  some values from: spindle checkpoint signaling
definition: Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_narrow_synonym: spindle checkpoint silencing
has_obo_namespace: biological_process
id: GO:0090233
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: negative regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of spindle checkpoint
annotated property: has_narrow_synonym
annotated target: spindle checkpoint silencing
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

fibroblast growth factor production
type: Class
subclass of: cytokine production
definition: The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: tb
creation date: 2010-02-05T02:33:33Z
has_obo_namespace: biological_process
id: GO:0090269
in_subset: gocheck do not annotate

Axiom
annotated source: fibroblast growth factor production
annotated property: definition
annotated target: The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF

nucleic acid metabolic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: macromolecule metabolic process
definition: Any cellular metabolic process involving nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/26133
term tracker item: https://github.com/geneontology/go-ontology/issues/27052
created by: tb
creation date: 2010-04-07T10:18:47Z
has_obo_namespace: biological_process
id: GO:0090304
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.

Axiom
annotated source: nucleic acid metabolic process
annotated property: definition
annotated target: Any cellular metabolic process involving nucleic acids.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

platelet-derived growth factor production
type: Class
subclass of: cytokine production
definition: The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: tb
creation date: 2010-07-12T10:32:27Z
has_obo_namespace: biological_process
id: GO:0090360
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: platelet-derived growth factor production
annotated property: definition
annotated target: The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:BHF

interleukin-17A production
type: Class
subclass of: interleukin-17 production
definition: The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bc
creation date: 2011-06-23T11:31:10Z
has_alternative_id: GO:0150154
has_exact_synonym: IL-17A production
has_narrow_synonym: interleukin-17A biosynthetic process
has_obo_namespace: biological_process
id: GO:0097087
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-17A production
annotated property: definition
annotated target: The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv
database_cross_reference: PMID:27901018

interleukin-17F production
type: Class
subclass of: interleukin-17 production
definition: The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2011-06-23T11:32:59Z
has_exact_synonym: IL-17F production
has_obo_namespace: biological_process
id: GO:0097088
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-17F production
annotated property: definition
annotated target: The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv
database_cross_reference: Wikipedia:Interleukin_17

response to bronchodilator
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.
created by: pr
creation date: 2012-08-01T16:13:31Z
has_exact_synonym: response to bronchodilator agent
has_obo_namespace: biological_process
has_related_synonym: response to broncholytic agent
id: GO:0097366
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to bronchodilator
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.
database_cross_reference: GOC:hp

chemokine (C-C motif) ligand 19 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2012-10-23T07:54:10Z
has_exact_synonym: CCL19 production
has_exact_synonym: EBI1 ligand chemokine production
has_exact_synonym: ELC production
has_exact_synonym: MIP-3-beta production
has_exact_synonym: macrophage inflammatory protein-3-beta production
has_obo_namespace: biological_process
id: GO:0097388
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 19 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

chemokine (C-C motif) ligand 21 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2012-10-23T07:56:26Z
has_exact_synonym: CCL21 production
has_obo_namespace: biological_process
id: GO:0097389
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-C motif) ligand 21 production
annotated property: definition
annotated target: The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

chemokine (C-X-C motif) ligand 12 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2012-10-23T07:57:28Z
has_exact_synonym: CXCL12 production
has_obo_namespace: biological_process
id: GO:0097390
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 12 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

chemokine (C-X-C motif) ligand 13 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2012-10-23T07:58:28Z
has_exact_synonym: CXCL13 production
has_obo_namespace: biological_process
id: GO:0097391
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 13 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

chemokine (C-X-C motif) ligand 16 production
type: Class
subclass of: chemokine production
definition: The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: pr
creation date: 2012-10-23T07:59:43Z
has_exact_synonym: CXCL16 production
has_obo_namespace: biological_process
id: GO:0097392
in_subset: gocheck do not annotate

Axiom
annotated source: chemokine (C-X-C motif) ligand 16 production
annotated property: definition
annotated target: The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:rv

sperm motility
type: Class
subclass of: cellular process
subclass of: reproductive process
definition: Any process involved in the controlled movement of a sperm cell.
created by: pr
creation date: 2016-09-01T12:00:45Z
has_exact_synonym: sperm movement
has_obo_namespace: biological_process
id: GO:0097722
in_subset: gocheck do not annotate

Axiom
annotated source: sperm motility
annotated property: definition
annotated target: Any process involved in the controlled movement of a sperm cell.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:krc

plasma membrane region
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: cellular anatomical structure
definition: A membrane that is a (regional) part of the plasma membrane.
created by: dos
creation date: 2014-03-06T11:55:32Z
has_exact_synonym: region of plasma membrane
has_obo_namespace: cellular_component
id: GO:0098590
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.

Axiom
annotated source: plasma membrane region
annotated property: definition
annotated target: A membrane that is a (regional) part of the plasma membrane.
database_cross_reference: GOC:dos

bone cell development
type: Class
subclass of: cellular process
subclass of: anatomical structure development
subclass of: Restriction
  on property: part of
  some values from: multicellular organism development
subclass of: Restriction
  on property: part of
  some values from: cellular process
definition: The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has_obo_namespace: biological_process
id: GO:0098751
in_subset: gocheck do not annotate
comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.

Axiom
annotated source: bone cell development
annotated property: definition
annotated target: The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
database_cross_reference: GOC:dos

meiotic cell cycle phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: happens during
  some values from: cell cycle
subclass of: Restriction
  on property: happens during
  some values from: reproductive process
subclass of: Restriction
  on property: ends during
  some values from: cell cycle
subclass of: Restriction
  on property: ends during
  some values from: reproductive process
definition: One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0098762
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:dos

mitotic cell cycle phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: happens during
  some values from: cell cycle
subclass of: Restriction
  on property: ends during
  some values from: cell cycle
definition: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
id: GO:0098763
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: mitotic cell cycle phase
annotated property: definition
annotated target: One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
database_cross_reference: GOC:dos

meiosis I cell cycle phase
type: Class
subclass of: meiotic cell cycle phase
definition: A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs.
has_obo_namespace: biological_process
id: GO:0098764
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiosis I cell cycle phase
annotated property: definition
annotated target: A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs.
database_cross_reference: GOC:dos

meiosis II cell cycle phase
type: Class
subclass of: meiotic cell cycle phase
definition: A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division).
has_obo_namespace: biological_process
id: GO:0098765
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiosis II cell cycle phase
annotated property: definition
annotated target: A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division).
database_cross_reference: GOC:dos

meiotic prometaphase I
type: Class
subclass of: meiosis I cell cycle phase
subclass of: Restriction
  on property: part of
  some values from: meiotic M phase
definition: The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate.
term tracker item: https://github.com/geneontology/go-ontology/issues/24374
has_obo_namespace: biological_process
id: GO:0098768
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: meiotic prometaphase I
annotated property: definition
annotated target: The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate.
database_cross_reference: PMID:16012859

molecular function regulator activity
type: Class
definition: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
term tracker item: https://github.com/geneontology/go-ontology/issues/20854
term tracker item: https://github.com/geneontology/go-ontology/issues/20862
term tracker item: https://github.com/geneontology/go-ontology/issues/25165
has_exact_synonym: molecular function regulator
has_obo_namespace: molecular_function
id: GO:0098772
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.

Axiom
annotated source: molecular function regulator activity
annotated property: definition
annotated target: A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pt

Golgi apparatus subcompartment
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: intracellular membrane-bounded organelle
definition: A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus.
term tracker item: https://github.com/geneontology/go-ontology/issues/30705
has_exact_synonym: Golgi subcompartment
has_obo_namespace: cellular_component
id: GO:0098791
in_subset: gocheck do not annotate

Axiom
annotated source: Golgi apparatus subcompartment
annotated property: definition
annotated target: A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus.
database_cross_reference: GOC:dos

mitochondrial protein-containing complex
type: Class
subclass of: Restriction
  on property: part of
  some values from: intracellular membrane-bounded organelle
definition: A protein complex that is part of a mitochondrion.
has_obo_namespace: cellular_component
has_related_synonym: mitochondrial protein complex
id: GO:0098798
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: mitochondrial protein-containing complex
annotated property: definition
annotated target: A protein complex that is part of a mitochondrion.
database_cross_reference: GOC:dos

plasma membrane signaling receptor complex
type: Class
subclass of: Restriction
  on property: part of
  some values from: cellular anatomical structure
definition: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.
has_obo_namespace: cellular_component
id: GO:0098802
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: plasma membrane signaling receptor complex
annotated property: definition
annotated target: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.
database_cross_reference: GOC:dos

supramolecular complex
type: Class
subclass of: cellular anatomical structure
definition: A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
has_obo_namespace: cellular_component
id: GO:0099080
in_subset: gocheck do not annotate

Axiom
annotated source: supramolecular complex
annotated property: definition
annotated target: A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
database_cross_reference: GOC:dos

chimeric sorocarp development
type: Class
subclass of: chimeric non-reproductive fruiting body development
definition: Development of a sorocarp formed by aggregation of cells with different genotypes.
has_obo_namespace: biological_process
id: GO:0099134
in_subset: gocheck do not annotate

Axiom
annotated source: chimeric sorocarp development
annotated property: definition
annotated target: Development of a sorocarp formed by aggregation of cells with different genotypes.
database_cross_reference: PMID:18272966

chimeric colonial development
type: Class
subclass of: anatomical structure development
subclass of: biological process involved in intraspecies interaction between organisms
definition: Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.
has_obo_namespace: biological_process
id: GO:0099135
in_subset: gocheck do not annotate

Axiom
annotated source: chimeric colonial development
annotated property: definition
annotated target: Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.
database_cross_reference: PMID:18272966

chimeric non-reproductive fruiting body development
type: Class
subclass of: chimeric colonial development
definition: Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.
has_obo_namespace: biological_process
id: GO:0099136
in_subset: gocheck do not annotate

Axiom
annotated source: chimeric non-reproductive fruiting body development
annotated property: definition
annotated target: Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.
database_cross_reference: PMID:18272966

cytosolic region
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.
term tracker item: https://github.com/geneontology/go-ontology/issues/31276
has_exact_synonym: region of cytosol
has_obo_namespace: cellular_component
id: GO:0099522
in_subset: gocheck do not annotate

Axiom
annotated source: cytosolic region
annotated property: definition
annotated target: Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.
database_cross_reference: GOC:dos

cytoplasmic region
type: Class
subclass of: cellular anatomical structure
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.
term tracker item: https://github.com/geneontology/go-ontology/issues/31276
has_obo_namespace: cellular_component
id: GO:0099568
in_subset: gocheck do not annotate

Axiom
annotated source: cytoplasmic region
annotated property: definition
annotated target: Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.
database_cross_reference: GOC:dos

cell cortex region
type: Class
subclass of: cytoplasmic region
definition: The complete extent of cell cortex that underlies some some region of the plasma membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/31276
has_exact_synonym: perimembrane region
has_obo_namespace: cellular_component
id: GO:0099738
in_subset: gocheck do not annotate

Axiom
annotated source: cell cortex region
annotated property: definition
annotated target: The complete extent of cell cortex that underlies some some region of the plasma membrane.
database_cross_reference: GOC:dos

spindle pole body separation
type: Class
subclass of: cell cycle process
subclass of: Restriction
  on property: part of
  some values from: organelle organization
subclass of: Restriction
  on property: part of
  some values from: cell cycle process
definition: The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.
created by: kmv
creation date: 2018-03-06T15:09:28Z
has_obo_namespace: biological_process
id: GO:0110100
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: spindle pole body separation
annotated property: definition
annotated target: The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.
database_cross_reference: GOC:vw

cellular anatomical structure
type: Class
definition: A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
term tracker item: https://github.com/geneontology/go-ontology/issues/24200
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
term tracker item: https://github.com/geneontology/go-ontology/issues/28978
created by: kmv
creation date: 2019-08-12T18:01:37Z
has_exact_synonym: cellular anatomical entity
has_obo_namespace: cellular_component
id: GO:0110165
in_subset: gocheck do not annotate
in_subset: goslim pir

Axiom
annotated source: cellular anatomical structure
annotated property: definition
annotated target: A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
database_cross_reference: GOC:kmv

GlcNAc(2)-PP-Dol mannosyltransferase activity
type: Class
definition: Catalysis of the transfer of a mannosyl residue to GlcNAc(2)-PP-Dol bearing 0-8 mannoses during synthesis of the N-glycan precursor.
term tracker item: https://github.com/geneontology/go-ontology/issues/30326
created by: sjm
creation date: 2025-05-28T07:19:38Z
has_obo_namespace: molecular_function
id: GO:0120562
in_subset: gocheck do not annotate

Axiom
annotated source: GlcNAc(2)-PP-Dol mannosyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a mannosyl residue to GlcNAc(2)-PP-Dol bearing 0-8 mannoses during synthesis of the N-glycan precursor.
database_cross_reference: GOC:curators

exocytic process
type: Class
subclass of: cellular process
subclass of: Restriction
  on property: part of
  some values from: transport
subclass of: Restriction
  on property: part of
  some values from: cellular process
definition: The cellular processes that contribute to exocytosis.
created by: pg
creation date: 2017-05-15T13:20:45Z
has_obo_namespace: biological_process
id: GO:0140029
in_subset: gocheck do not annotate

Axiom
annotated source: exocytic process
annotated property: definition
annotated target: The cellular processes that contribute to exocytosis.
database_cross_reference: Wikipedia:Exocytosis

transcription regulator activity
type: Class
definition: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/13588
term tracker item: https://github.com/geneontology/go-ontology/issues/23609
created by: pg
creation date: 2017-10-18T07:05:44Z
has_obo_namespace: molecular_function
id: GO:0140110
in_subset: gocheck do not annotate
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: transcription regulator activity
annotated property: definition
annotated target: A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:pg
database_cross_reference: GOC:txnOH-2018
database_cross_reference: Wikipedia:Transcription_factor

nucleocytoplasmic carrier activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: intracellular transport
definition: Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/14336
term tracker item: https://github.com/geneontology/go-ontology/issues/17399
created by: pg
creation date: 2017-12-06T13:40:40Z
has_alternative_id: GO:0061717
has_alternative_id: GO:0090631
has_exact_synonym: nucleocytoplasmic importin/exportin activity
has_narrow_synonym: miRNA transporter activity
has_narrow_synonym: pre-miRNA transporter activity
has_obo_namespace: molecular_function
id: GO:0140142
in_subset: gocheck do not annotate

Axiom
annotated source: nucleocytoplasmic carrier activity
annotated property: definition
annotated target: Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.
database_cross_reference: GOC:pg

extracellular protein-containing complex
type: Class
subclass of: Restriction
  on property: part of
  some values from: cellular anatomical structure
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/31673
created by: pg
creation date: 2020-09-09T05:12:38Z
has_broad_synonym: extracellular protein complex
has_obo_namespace: cellular_component
id: GO:0140392
in_subset: gocheck do not annotate

Axiom
annotated source: extracellular protein-containing complex
annotated property: definition
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.
database_cross_reference: GOC:curators

nuclear protein-containing complex
type: Class
subclass of: Restriction
  on property: part of
  some values from: intracellular membrane-bounded organelle
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
created by: pg
creation date: 2020-09-09T05:12:38Z
has_exact_synonym: nuclear complex
has_obo_namespace: cellular_component
id: GO:0140513
in_subset: gocheck do not annotate

Axiom
annotated source: nuclear protein-containing complex
annotated property: definition
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
database_cross_reference: GOC:pg

ATP-dependent activity
type: Class
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324

cyclic GMP-AMP synthase activity
type: Class
definition: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.
term tracker item: https://github.com/geneontology/go-ontology/issues/21980
created by: pg
creation date: 2021-08-27T05:05:37Z
has_exact_synonym: cyclic-GMP-AMP synthase activity
has_obo_namespace: molecular_function
id: GO:0140699
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that describes the position of the phosphate group on the cGAMP molecule.

Axiom
annotated source: cyclic GMP-AMP synthase activity
annotated property: definition
annotated target: Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.
database_cross_reference: PMID:23258413

cyclic GMP-AMP binding
type: Class
definition: Binding to cyclic GMP-AMP (cGAMP) nucleotide.
term tracker item: https://github.com/geneontology/go-ontology/issues/21980
created by: pg
creation date: 2021-08-27T05:39:31Z
has_obo_namespace: molecular_function
id: GO:0140702
in_subset: gocheck do not annotate

Axiom
annotated source: cyclic GMP-AMP binding
annotated property: definition
annotated target: Binding to cyclic GMP-AMP (cGAMP) nucleotide.
database_cross_reference: PMID:23258412

amphiregulin production
type: Class
subclass of: cytokine production
definition: The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
term tracker item: https://github.com/geneontology/go-ontology/issues/21878
created by: pg
creation date: 2021-11-24T07:09:44Z
has_broad_synonym: AREG production
has_obo_namespace: biological_process
id: GO:0140730
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: amphiregulin production
annotated property: definition
annotated target: The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
database_cross_reference: PMID:24463227

XCL1 production
type: Class
subclass of: cytokine production
definition: The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
term tracker item: https://github.com/geneontology/go-ontology/issues/23071
created by: pg
creation date: 2022-03-24T07:11:34Z
database_cross_reference: Wikipedia:XCL1
has_exact_synonym: lymphotactin production
has_obo_namespace: biological_process
id: GO:0140779
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.

Axiom
annotated source: XCL1 production
annotated property: definition
annotated target: The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: PMID:7973732

nucleic acid biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: nucleobase-containing compound biosynthetic process
subclass of: nucleic acid metabolic process
definition: The biosynthetic process resulting in the formation of a nucleic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/27408
term tracker item: https://github.com/geneontology/go-ontology/issues/27633
created by: pg
creation date: 2024-03-25T07:33:40Z
has_obo_namespace: biological_process
id: GO:0141187
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.

Axiom
annotated source: nucleic acid biosynthetic process
annotated property: definition
annotated target: The biosynthetic process resulting in the formation of a nucleic acid.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

nucleic acid catabolic process
type: Class
subclass of: macromolecule catabolic process
subclass of: nucleobase-containing compound catabolic process
subclass of: nucleic acid metabolic process
definition: The cellular DNA metabolic process resulting in the breakdown of a nucleic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/27408
term tracker item: https://github.com/geneontology/go-ontology/issues/27633
created by: pg
creation date: 2024-03-25T07:35:06Z
has_obo_namespace: biological_process
id: GO:0141188
in_subset: gocheck do not annotate
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.

Axiom
annotated source: nucleic acid catabolic process
annotated property: definition
annotated target: The cellular DNA metabolic process resulting in the breakdown of a nucleic acid.
database_cross_reference: GOC:curators

interleukin-37 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bc
creation date: 2019-12-08T08:43:09Z
has_narrow_synonym: interleukin-37 biosynthetic process
has_obo_namespace: biological_process
id: GO:0150137
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-37 production
annotated property: definition
annotated target: The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:aruk
database_cross_reference: PMID:30362558

interleukin-34 production
type: Class
subclass of: cytokine production
definition: The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
created by: bc
creation date: 2020-01-06T16:25:25Z
has_obo_namespace: biological_process
id: GO:0150155
in_subset: gocheck do not annotate

Axiom
annotated source: interleukin-34 production
annotated property: definition
annotated target: The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
database_cross_reference: GOC:aruk
database_cross_reference: PMID:26754294

anestrus phase
type: Class
subclass of: biological phase
definition: A biological phase of reproductive dormancy characterized by the temporary cessation of reproductive cyclicity, marked by the absence of ovarian follicular development, estrous behavior, and ovulation. This phase represents a period of sexual quiescence between estrous cycles or breeding seasons.
term tracker item: https://github.com/geneontology/go-ontology/issues/30248
created by: rynl
creation date: 2025-05-14T00:20:22Z
has_obo_namespace: biological_process
id: GO:0160266
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

Axiom
annotated source: anestrus phase
annotated property: definition
annotated target: A biological phase of reproductive dormancy characterized by the temporary cessation of reproductive cyclicity, marked by the absence of ovarian follicular development, estrous behavior, and ovulation. This phase represents a period of sexual quiescence between estrous cycles or breeding seasons.
database_cross_reference: PMID:34635709
database_cross_reference: WIKIPEDIA:Estrous_cycle

proteinogenic amino acid biosynthetic process
type: Class
subclass of: small molecule biosynthetic process
subclass of: proteinogenic amino acid metabolic process
definition: The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/23268
term tracker item: https://github.com/geneontology/go-ontology/issues/31996
created by: ew
creation date: 2023-12-18T16:28:19Z
has_exact_synonym: proteinogenic amino acid anabolism
has_exact_synonym: proteinogenic amino acid biosynthesis
has_exact_synonym: proteinogenic amino acid formation
has_exact_synonym: proteinogenic amino acid synthesis
has_obo_namespace: biological_process
id: GO:0170038
in_subset: gocheck do not annotate

Axiom
annotated source: proteinogenic amino acid biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
database_cross_reference: GOC:ew

proteinogenic amino acid metabolic process
type: Class
subclass of: carboxylic acid metabolic process
subclass of: primary metabolic process
definition: The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/23268
term tracker item: https://github.com/geneontology/go-ontology/issues/31996
created by: ew
creation date: 2023-12-18T17:31:08Z
has_exact_synonym: proteinogenic amino acid metabolism
has_obo_namespace: biological_process
id: GO:0170039
in_subset: gocheck do not annotate

Axiom
annotated source: proteinogenic amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
database_cross_reference: GOC:ew

proteinogenic amino acid catabolic process
type: Class
subclass of: small molecule catabolic process
subclass of: proteinogenic amino acid metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/23268
term tracker item: https://github.com/geneontology/go-ontology/issues/31996
created by: ew
creation date: 2023-12-18T17:41:14Z
has_exact_synonym: proteinogenic amino acid breakdown
has_exact_synonym: proteinogenic amino acid catabolism
has_exact_synonym: proteinogenic amino acid degradation
has_obo_namespace: biological_process
id: GO:0170040
in_subset: gocheck do not annotate

Axiom
annotated source: proteinogenic amino acid catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
database_cross_reference: GOC:ew

non-proteinogenic amino acid biosynthetic process
type: Class
subclass of: carboxylic acid metabolic process
subclass of: primary metabolic process
subclass of: small molecule biosynthetic process
definition: The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/23269
term tracker item: https://github.com/geneontology/go-ontology/issues/31996
created by: ew
creation date: 2023-12-18T19:03:08Z
has_exact_synonym: non-proteinogenic amino acid anabolism
has_exact_synonym: non-proteinogenic amino acid formation
has_exact_synonym: non-proteinogenic amino acid synthesis
has_exact_synonym: non-proteinogenic biosynthesis
has_obo_namespace: biological_process
id: GO:0170043
in_subset: gocheck do not annotate

Axiom
annotated source: non-proteinogenic amino acid biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids.
database_cross_reference: GOC:ew

non-proteinogenic amino acid catabolic process
type: Class
subclass of: carboxylic acid metabolic process
subclass of: primary metabolic process
subclass of: small molecule catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/23269
term tracker item: https://github.com/geneontology/go-ontology/issues/31996
created by: ew
creation date: 2023-12-18T19:27:05Z
has_exact_synonym: non-proteinogenic amino acid breakdown
has_exact_synonym: non-proteinogenic amino acid catabolism
has_exact_synonym: non-proteinogenic amino acid degradation
has_obo_namespace: biological_process
id: GO:0170044
in_subset: gocheck do not annotate

Axiom
annotated source: non-proteinogenic amino acid catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids.
database_cross_reference: GOC:ew

lipid transmembrane transporter activity
type: Class
subclass of: transporter activity
subclass of: Restriction
  on property: part of
  some values from: transport
subclass of: Restriction
  on property: part of
  some values from: cellular process
definition: Enables the transfer of a lipid from one side of a membrane to the other.
term tracker item: https://github.com/geneontology/go-ontology/issues/27252
created by: ew
creation date: 2024-03-15T18:47:58Z
has_obo_namespace: molecular_function
id: GO:0170055
in_subset: gocheck do not annotate

Axiom
annotated source: lipid transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a lipid from one side of a membrane to the other.
database_cross_reference: GOC:curators

translation factor activity
type: Class
definition: A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation.
term tracker item: https://github.com/geneontology/go-ontology/issues/29089
created by: vw
creation date: 2025-01-20T11:51:48Z
has_obo_namespace: molecular_function
id: GO:0180051
in_subset: gocheck do not annotate

Axiom
annotated source: translation factor activity
annotated property: definition
annotated target: A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation.
database_cross_reference: GOC:pg

negative regulation of cellular response to alkaline pH
type: Class
subclass of: negative regulation of cellular process
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: cellular response to abiotic stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular response to abiotic stimulus
definition: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity.
created by: pr
creation date: 2012-01-26T02:35:03Z
has_broad_synonym: negative regulation of cellular response to alkalinity
has_exact_synonym: down regulation of cellular response to alkaline pH
has_exact_synonym: down regulation of cellular response to basic pH
has_exact_synonym: down-regulation of cellular response to alkaline pH
has_exact_synonym: down-regulation of cellular response to basic pH
has_exact_synonym: downregulation of cellular response to alkaline pH
has_exact_synonym: downregulation of cellular response to basic pH
has_exact_synonym: negative regulation of cellular response to basic pH
has_narrow_synonym: inhibition of cellular response to alkaline pH
has_narrow_synonym: inhibition of cellular response to alkalinity
has_narrow_synonym: inhibition of cellular response to basic pH
has_obo_namespace: biological_process
has_related_synonym: down regulation of cellular response to alkalinity
has_related_synonym: down-regulation of cellular response to alkalinity
has_related_synonym: downregulation of cellular response to alkalinity
id: GO:1900068
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dgf
database_cross_reference: PMID:12509465
database_cross_reference: PMID:17023428

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: down regulation of cellular response to alkaline pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: down regulation of cellular response to basic pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: down-regulation of cellular response to alkaline pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: down-regulation of cellular response to basic pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: downregulation of cellular response to alkaline pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: downregulation of cellular response to basic pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_exact_synonym
annotated target: negative regulation of cellular response to basic pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_narrow_synonym
annotated target: inhibition of cellular response to alkaline pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_narrow_synonym
annotated target: inhibition of cellular response to alkalinity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_narrow_synonym
annotated target: inhibition of cellular response to basic pH
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_related_synonym
annotated target: down regulation of cellular response to alkalinity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_related_synonym
annotated target: down-regulation of cellular response to alkalinity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular response to alkaline pH
annotated property: has_related_synonym
annotated target: downregulation of cellular response to alkalinity
database_cross_reference: GOC:TermGenie

negative regulation of cellular hyperosmotic salinity response
type: Class
subclass of: negative regulation of cellular process
subclass of: negative regulation of response to stimulus
subclass of: regulation of response to stress
subclass of: Restriction
  on property: regulates
  some values from: cellular response to chemical stimulus
subclass of: Restriction
  on property: regulates
  some values from: cellular response to abiotic stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular response to chemical stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: cellular response to abiotic stimulus
definition: Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response.
created by: pr
creation date: 2012-01-26T02:45:43Z
has_exact_synonym: down regulation of cellular response to hyperosmotic salt stress
has_exact_synonym: down-regulation of cellular response to hyperosmotic salt stress
has_exact_synonym: downregulation of cellular response to hyperosmotic salt stress
has_exact_synonym: negative regulation of cellular response to hyperosmotic salt stress
has_narrow_synonym: inhibition of cellular hyperosmotic salinity response
has_narrow_synonym: inhibition of cellular response to hyperosmotic salt stress
has_obo_namespace: biological_process
has_related_synonym: down regulation of cellular hyperosmotic salinity response
has_related_synonym: down-regulation of cellular hyperosmotic salinity response
has_related_synonym: downregulation of cellular hyperosmotic salinity response
id: GO:1900070
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_related_synonym
annotated target: downregulation of cellular hyperosmotic salinity response
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dgf
database_cross_reference: PMID:16278455

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_exact_synonym
annotated target: down regulation of cellular response to hyperosmotic salt stress
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_exact_synonym
annotated target: down-regulation of cellular response to hyperosmotic salt stress
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_exact_synonym
annotated target: downregulation of cellular response to hyperosmotic salt stress
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_exact_synonym
annotated target: negative regulation of cellular response to hyperosmotic salt stress
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_narrow_synonym
annotated target: inhibition of cellular hyperosmotic salinity response
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_narrow_synonym
annotated target: inhibition of cellular response to hyperosmotic salt stress
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_related_synonym
annotated target: down regulation of cellular hyperosmotic salinity response
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cellular hyperosmotic salinity response
annotated property: has_related_synonym
annotated target: down-regulation of cellular hyperosmotic salinity response
database_cross_reference: GOC:TermGenie

positive regulation of sulfite transmembrane transport
type: Class
subclass of: regulation of localization
subclass of: positive regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: transport
subclass of: Restriction
  on property: positively regulates
  some values from: transport
definition: Any process that activates or increases the frequency, rate or extent of sulfite transmembrane transport.
term tracker item: https://github.com/geneontology/go-ontology/issues/28653
created by: dph
creation date: 2012-01-26T08:41:16Z
has_exact_synonym: positive regulation of sulfite transport
has_exact_synonym: positive regulation of sulphite transport
has_exact_synonym: up regulation of sulphite transport
has_exact_synonym: up-regulation of sulphite transport
has_exact_synonym: upregulation of sulphite transport
has_narrow_synonym: activation of sulfite transport
has_narrow_synonym: activation of sulphite transport
has_obo_namespace: biological_process
has_related_synonym: up regulation of sulfite transport
has_related_synonym: up-regulation of sulfite transport
has_related_synonym: upregulation of sulfite transport
id: GO:1900072
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of sulfite transmembrane transport.
database_cross_reference: GOC:TermGenie
database_cross_reference: PMID:10234785
database_cross_reference: PMID:10870099

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_exact_synonym
annotated target: positive regulation of sulphite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_exact_synonym
annotated target: up regulation of sulphite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_exact_synonym
annotated target: up-regulation of sulphite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_exact_synonym
annotated target: upregulation of sulphite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_narrow_synonym
annotated target: activation of sulfite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_narrow_synonym
annotated target: activation of sulphite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_related_synonym
annotated target: up regulation of sulfite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_related_synonym
annotated target: up-regulation of sulfite transport
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of sulfite transmembrane transport
annotated property: has_related_synonym
annotated target: upregulation of sulfite transport
database_cross_reference: GOC:TermGenie

regulation of receptor binding
type: Class
subclass of: regulation of protein binding
definition: Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor.
created by: bf
creation date: 2012-02-22T11:40:53Z
has_narrow_synonym: regulation of receptor ligand
has_obo_namespace: biological_process
id: GO:1900120
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of receptor binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:signaling

Axiom
annotated source: regulation of receptor binding
annotated property: has_narrow_synonym
annotated target: regulation of receptor ligand
database_cross_reference: GOC:TermGenie

negative regulation of receptor binding
type: Class
subclass of: negative regulation of protein binding
subclass of: regulation of receptor binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
created by: bf
creation date: 2012-02-22T11:40:57Z
has_exact_synonym: down regulation of receptor binding
has_exact_synonym: down-regulation of receptor binding
has_exact_synonym: downregulation of receptor binding
has_narrow_synonym: inhibition of receptor binding
has_narrow_synonym: inhibition of receptor ligand
has_obo_namespace: biological_process
has_related_synonym: down regulation of receptor-associated protein activity
id: GO:1900121
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of receptor binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:signaling

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_exact_synonym
annotated target: down regulation of receptor binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_exact_synonym
annotated target: down-regulation of receptor binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_exact_synonym
annotated target: downregulation of receptor binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_narrow_synonym
annotated target: inhibition of receptor binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_narrow_synonym
annotated target: inhibition of receptor ligand
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of receptor binding
annotated property: has_related_synonym
annotated target: down regulation of receptor-associated protein activity
database_cross_reference: GOC:TermGenie

negative regulation of lipid binding
type: Class
subclass of: negative regulation of binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.
created by: pm
creation date: 2012-02-23T04:05:07Z
has_exact_synonym: down regulation of lipid binding
has_exact_synonym: down-regulation of lipid binding
has_exact_synonym: downregulation of lipid binding
has_narrow_synonym: inhibition of lipid binding
has_obo_namespace: biological_process
id: GO:1900131
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of lipid binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pm

Axiom
annotated source: negative regulation of lipid binding
annotated property: has_exact_synonym
annotated target: down regulation of lipid binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of lipid binding
annotated property: has_exact_synonym
annotated target: down-regulation of lipid binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of lipid binding
annotated property: has_exact_synonym
annotated target: downregulation of lipid binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of lipid binding
annotated property: has_narrow_synonym
annotated target: inhibition of lipid binding
database_cross_reference: GOC:TermGenie

regulation of alcohol catabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: alcohol catabolic process
subclass of: regulation of catabolic process
subclass of: regulation of small molecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: alcohol catabolic process
definition: Any process that modulates the frequency, rate or extent of alcohol catabolic process within a cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/28908
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: krc
creation date: 2012-04-20T10:21:18Z
has_obo_namespace: biological_process
id: GO:1900419
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of alcohol catabolic process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of alcohol catabolic process within a cell.
database_cross_reference: GOC:TermGenie

negative regulation of alcohol catabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: alcohol catabolic process
subclass of: negative regulation of small molecule metabolic process
subclass of: regulation of alcohol catabolic process
subclass of: Restriction
  on property: negatively regulates
  some values from: alcohol catabolic process
definition: Any process that stops, prevents or reduces the frequency, rate or extent of alcohol catabolic process within a cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: krc
creation date: 2012-04-20T10:21:28Z
has_exact_synonym: down regulation of cellular alcohol catabolic process
has_exact_synonym: down-regulation of cellular alcohol catabolic process
has_exact_synonym: downregulation of cellular alcohol catabolic process
has_narrow_synonym: inhibition of cellular alcohol catabolic process
has_obo_namespace: biological_process
id: GO:1900420
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of alcohol catabolic process
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of alcohol catabolic process within a cell.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: down regulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: down-regulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: downregulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol catabolic process
annotated property: has_narrow_synonym
annotated target: inhibition of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

positive regulation of alcohol catabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: alcohol catabolic process
subclass of: positive regulation of small molecule metabolic process
subclass of: regulation of alcohol catabolic process
subclass of: Restriction
  on property: positively regulates
  some values from: alcohol catabolic process
definition: Any process that activates or increases the frequency, rate or extent of alcohol catabolic process within a cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/28908
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: krc
creation date: 2012-04-20T10:21:46Z
has_exact_synonym: up regulation of cellular alcohol catabolic process
has_exact_synonym: up-regulation of cellular alcohol catabolic process
has_exact_synonym: upregulation of cellular alcohol catabolic process
has_narrow_synonym: activation of cellular alcohol catabolic process
has_obo_namespace: biological_process
id: GO:1900421
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of alcohol catabolic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of alcohol catabolic process within a cell.
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: up regulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: up-regulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol catabolic process
annotated property: has_exact_synonym
annotated target: upregulation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol catabolic process
annotated property: has_narrow_synonym
annotated target: activation of cellular alcohol catabolic process
database_cross_reference: GOC:TermGenie

response to nitrogen compound
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
term tracker item: https://github.com/geneontology/go-ontology/issues/27194
created by: pr
creation date: 2012-12-13T15:06:08Z
has_exact_synonym: response to nitrogen molecular entity
has_obo_namespace: biological_process
id: GO:1901698
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to nitrogen compound
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pr

cellular response to nitrogen compound
type: Class
subclass of: cellular response to chemical stimulus
subclass of: response to nitrogen compound
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
term tracker item: https://github.com/geneontology/go-ontology/issues/27194
created by: pr
creation date: 2012-12-13T15:06:13Z
has_exact_synonym: cellular response to nitrogen molecular entity
has_obo_namespace: biological_process
id: GO:1901699
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to nitrogen compound
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pr

response to oxygen-containing compound
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.
term tracker item: https://github.com/geneontology/go-ontology/issues/27194
created by: pr
creation date: 2012-12-13T15:11:37Z
has_exact_synonym: response to oxygen molecular entity
has_obo_namespace: biological_process
id: GO:1901700
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to oxygen-containing compound
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pr

regulation of calcium ion binding
type: Class
subclass of: regulation of binding
subclass of: Restriction
  on property: regulates
  some values from: ion binding
definition: Any process that modulates the frequency, rate or extent of calcium ion binding.
created by: rl
creation date: 2013-02-06T12:38:12Z
has_obo_namespace: biological_process
has_related_synonym: regulation of calcium ion storage activity
id: GO:1901876
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of calcium ion binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of calcium ion binding.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:rl
database_cross_reference: PMID:16432188

Axiom
annotated source: regulation of calcium ion binding
annotated property: has_related_synonym
annotated target: regulation of calcium ion storage activity
database_cross_reference: GOC:TermGenie

regulation of cell cycle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cell cycle checkpoint signaling
subclass of: regulation of response to stimulus
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cell cycle checkpoint signaling
definition: Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
created by: jl
creation date: 2013-03-06T15:10:20Z
has_alternative_id: GO:2001047
has_obo_namespace: biological_process
has_related_synonym: regulation of G1/S checkpoint
has_related_synonym: regulation of G1/S transition checkpoint
id: GO:1901976
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: regulation of cell cycle checkpoint
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: PMID:23028116

Axiom
annotated source: regulation of cell cycle checkpoint
annotated property: has_related_synonym
annotated target: regulation of G1/S checkpoint
database_cross_reference: GOC:obol

negative regulation of cell cycle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: cell cycle checkpoint signaling
subclass of: positive regulation of cellular process
subclass of: negative regulation of cellular process
subclass of: negative regulation of response to stimulus
subclass of: regulation of cell cycle checkpoint
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle checkpoint signaling
subclass of: Restriction
  on property: positively regulates
  some values from: cell cycle
subclass of: Restriction
  on property: positively regulates
  some values from: cell cycle process
definition: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.
created by: jl
creation date: 2013-03-06T15:10:29Z
has_alternative_id: GO:2001048
has_exact_synonym: down regulation of cell cycle checkpoint
has_exact_synonym: down-regulation of cell cycle checkpoint
has_exact_synonym: downregulation of cell cycle checkpoint
has_narrow_synonym: inhibition of cell cycle checkpoint
has_obo_namespace: biological_process
has_related_synonym: negative regulation of G1/S checkpoint
has_related_synonym: negative regulation of G1/S transition checkpoint
id: GO:1901977
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: PMID:23028116

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: down regulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: down-regulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: downregulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_narrow_synonym
annotated target: inhibition of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_related_synonym
annotated target: negative regulation of G1/S checkpoint
database_cross_reference: GOC:obol

regulation of mRNA binding
type: Class
subclass of: regulation of binding
definition: Any process that modulates the frequency, rate or extent of mRNA binding.
created by: rb
creation date: 2013-09-13T18:57:15Z
has_obo_namespace: biological_process
id: GO:1902415
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of mRNA binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of mRNA binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:rb
database_cross_reference: PMID:22890846

positive regulation of mRNA binding
type: Class
subclass of: regulation of mRNA binding
subclass of: positive regulation of RNA binding
definition: Any process that activates or increases the frequency, rate or extent of mRNA binding.
created by: rb
creation date: 2013-09-13T18:57:24Z
has_exact_synonym: up regulation of mRNA binding
has_exact_synonym: up-regulation of mRNA binding
has_exact_synonym: upregulation of mRNA binding
has_narrow_synonym: activation of mRNA binding
has_obo_namespace: biological_process
id: GO:1902416
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of mRNA binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of mRNA binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:rb
database_cross_reference: PMID:22890846

Axiom
annotated source: positive regulation of mRNA binding
annotated property: has_exact_synonym
annotated target: up regulation of mRNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of mRNA binding
annotated property: has_exact_synonym
annotated target: up-regulation of mRNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of mRNA binding
annotated property: has_exact_synonym
annotated target: upregulation of mRNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of mRNA binding
annotated property: has_narrow_synonym
annotated target: activation of mRNA binding
database_cross_reference: GOC:TermGenie

response to cyclophosphamide
type: Class
subclass of: response to nitrogen compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.
created by: dw
creation date: 2013-12-02T09:34:08Z
has_obo_namespace: biological_process
id: GO:1902518
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to cyclophosphamide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to docetaxel trihydrate
type: Class
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus.
created by: dw
creation date: 2013-12-02T09:44:04Z
has_obo_namespace: biological_process
has_related_synonym: response to docetaxel
id: GO:1902519
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to docetaxel trihydrate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to doxorubicin
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus.
created by: dw
creation date: 2013-12-02T09:44:13Z
has_obo_namespace: biological_process
id: GO:1902520
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to doxorubicin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to etoposide
type: Class
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus.
created by: dw
creation date: 2013-12-02T09:44:22Z
has_obo_namespace: biological_process
id: GO:1902521
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to etoposide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to 4'-epidoxorubicin
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus.
created by: dw
creation date: 2013-12-02T09:44:31Z
has_obo_namespace: biological_process
has_related_synonym: response to epirubicin
id: GO:1902522
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to 4'-epidoxorubicin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

negative regulation of alcohol biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively regulates
    some values from: alcohol biosynthetic process
subclass of: negative regulation of biosynthetic process
subclass of: negative regulation of small molecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: alcohol biosynthetic process
subclass of: Restriction
  on property: negatively regulates
  some values from: alcohol biosynthetic process
definition: Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: tt
creation date: 2014-04-22T21:55:13Z
has_broad_synonym: negative regulation of solventogenesis
has_exact_synonym: down regulation of alcohol anabolism
has_exact_synonym: down regulation of alcohol biosynthesis
has_exact_synonym: down regulation of alcohol biosynthetic process
has_exact_synonym: down regulation of alcohol formation
has_exact_synonym: down regulation of alcohol synthesis
has_exact_synonym: down-regulation of alcohol anabolism
has_exact_synonym: down-regulation of alcohol biosynthesis
has_exact_synonym: down-regulation of alcohol biosynthetic process
has_exact_synonym: down-regulation of alcohol formation
has_exact_synonym: down-regulation of alcohol synthesis
has_exact_synonym: downregulation of alcohol anabolism
has_exact_synonym: downregulation of alcohol biosynthesis
has_exact_synonym: downregulation of alcohol biosynthetic process
has_exact_synonym: downregulation of alcohol formation
has_exact_synonym: downregulation of alcohol synthesis
has_exact_synonym: negative regulation of alcohol anabolism
has_exact_synonym: negative regulation of alcohol biosynthesis
has_exact_synonym: negative regulation of alcohol formation
has_exact_synonym: negative regulation of alcohol synthesis
has_narrow_synonym: inhibition of alcohol anabolism
has_narrow_synonym: inhibition of alcohol biosynthesis
has_narrow_synonym: inhibition of alcohol biosynthetic process
has_narrow_synonym: inhibition of alcohol formation
has_narrow_synonym: inhibition of alcohol synthesis
has_obo_namespace: biological_process
id: GO:1902931
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mengo_curators
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:23332010

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down regulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down-regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down-regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down-regulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down-regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: down-regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: downregulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: downregulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: downregulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: downregulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: downregulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: negative regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: negative regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: negative regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: negative regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: inhibition of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: inhibition of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: inhibition of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: inhibition of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: inhibition of alcohol synthesis
database_cross_reference: GOC:TermGenie

positive regulation of alcohol biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively regulates
    some values from: alcohol biosynthetic process
subclass of: positive regulation of biosynthetic process
subclass of: positive regulation of small molecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: alcohol biosynthetic process
subclass of: Restriction
  on property: positively regulates
  some values from: alcohol biosynthetic process
definition: Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
created by: tt
creation date: 2014-04-22T21:55:19Z
has_broad_synonym: positive regulation of solventogenesis
has_exact_synonym: positive regulation of alcohol anabolism
has_exact_synonym: positive regulation of alcohol biosynthesis
has_exact_synonym: positive regulation of alcohol formation
has_exact_synonym: positive regulation of alcohol synthesis
has_exact_synonym: up regulation of alcohol anabolism
has_exact_synonym: up regulation of alcohol biosynthesis
has_exact_synonym: up regulation of alcohol biosynthetic process
has_exact_synonym: up regulation of alcohol formation
has_exact_synonym: up regulation of alcohol synthesis
has_exact_synonym: up-regulation of alcohol anabolism
has_exact_synonym: up-regulation of alcohol biosynthesis
has_exact_synonym: up-regulation of alcohol biosynthetic process
has_exact_synonym: up-regulation of alcohol formation
has_exact_synonym: up-regulation of alcohol synthesis
has_exact_synonym: upregulation of alcohol anabolism
has_exact_synonym: upregulation of alcohol biosynthesis
has_exact_synonym: upregulation of alcohol biosynthetic process
has_exact_synonym: upregulation of alcohol formation
has_exact_synonym: upregulation of alcohol synthesis
has_narrow_synonym: activation of alcohol anabolism
has_narrow_synonym: activation of alcohol biosynthesis
has_narrow_synonym: activation of alcohol biosynthetic process
has_narrow_synonym: activation of alcohol formation
has_narrow_synonym: activation of alcohol synthesis
has_obo_namespace: biological_process
id: GO:1902932
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mengo_curators
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:23332010

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: positive regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: positive regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: positive regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: positive regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up regulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up-regulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up-regulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up-regulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up-regulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: up-regulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: upregulation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: upregulation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: upregulation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: upregulation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_exact_synonym
annotated target: upregulation of alcohol synthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: activation of alcohol anabolism
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: activation of alcohol biosynthesis
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: activation of alcohol biosynthetic process
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: activation of alcohol formation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of alcohol biosynthetic process
annotated property: has_narrow_synonym
annotated target: activation of alcohol synthesis
database_cross_reference: GOC:TermGenie

regulation of RNA polymerase II regulatory region sequence-specific DNA binding
type: Class
subclass of: regulation of transcription regulatory region DNA binding
definition: Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
created by: dph
creation date: 2014-05-15T17:55:54Z
has_obo_namespace: biological_process
id: GO:1903025
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dph
database_cross_reference: GOC:krc
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:20026326

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
type: Class
subclass of: regulation of RNA polymerase II regulatory region sequence-specific DNA binding
subclass of: negative regulation of transcription regulatory region DNA binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
created by: dph
creation date: 2014-05-15T17:56:00Z
has_exact_synonym: down regulation of RNA polymerase II regulatory region sequence-specific DNA binding
has_exact_synonym: down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding
has_exact_synonym: downregulation of RNA polymerase II regulatory region sequence-specific DNA binding
has_narrow_synonym: inhibition of RNA polymerase II regulatory region sequence-specific DNA binding
has_obo_namespace: biological_process
id: GO:1903026
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dph
database_cross_reference: GOC:krc
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:20026326

Axiom
annotated source: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: has_exact_synonym
annotated target: down regulation of RNA polymerase II regulatory region sequence-specific DNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: has_exact_synonym
annotated target: down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: has_exact_synonym
annotated target: downregulation of RNA polymerase II regulatory region sequence-specific DNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
annotated property: has_narrow_synonym
annotated target: inhibition of RNA polymerase II regulatory region sequence-specific DNA binding
database_cross_reference: GOC:TermGenie

meiotic cell cycle process
type: Class
subclass of: cell cycle process
subclass of: reproductive process
subclass of: Restriction
  on property: part of
  some values from: sexual reproduction
disjoint with: mitotic cell cycle process
definition: A process that is part of the meiotic cell cycle.
created by: jl
creation date: 2014-05-22T14:22:28Z
has_obo_namespace: biological_process
id: GO:1903046
in_subset: gocheck do not annotate
in_subset: goslim pombe

Axiom
annotated source: meiotic cell cycle process
annotated property: definition
annotated target: A process that is part of the meiotic cell cycle.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GO_REF:0000060

mitotic cell cycle process
type: Class
subclass of: cell cycle process
definition: A process that is part of the mitotic cell cycle.
created by: jl
creation date: 2014-05-22T14:22:34Z
has_obo_namespace: biological_process
id: GO:1903047
in_subset: gocheck do not annotate

Axiom
annotated source: mitotic cell cycle process
annotated property: definition
annotated target: A process that is part of the mitotic cell cycle.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GO_REF:0000060

response to simvastatin
type: Class
subclass of: response to statin
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug.
created by: hp
creation date: 2014-09-25T10:58:06Z
has_obo_namespace: biological_process
id: GO:1903491
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to simvastatin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:sl
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:23100282

regulation of mitotic spindle checkpoint
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: mitotic spindle checkpoint signaling
subclass of: regulation of spindle checkpoint
subclass of: Restriction
  on property: regulates
  some values from: mitotic spindle checkpoint signaling
definition: Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint.
created by: al
creation date: 2014-10-01T13:52:57Z
has_exact_synonym: regulation of mitotic cell cycle spindle checkpoint
has_obo_namespace: biological_process
id: GO:1903504
in_subset: gocheck do not annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).

Axiom
annotated source: regulation of mitotic spindle checkpoint
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:23442800

Axiom
annotated source: regulation of mitotic spindle checkpoint
annotated property: has_exact_synonym
annotated target: regulation of mitotic cell cycle spindle checkpoint
database_cross_reference: GOC:TermGenie

positive regulation of GTP binding
type: Class
subclass of: positive regulation of binding
subclass of: Restriction
  on property: regulates
  some values from: ion binding
subclass of: Restriction
  on property: positively regulates
  some values from: ion binding
definition: Any process that activates or increases the frequency, rate or extent of GTP binding.
created by: sl
creation date: 2015-07-02T20:35:07Z
has_exact_synonym: up regulation of GTP binding
has_exact_synonym: up-regulation of GTP binding
has_exact_synonym: upregulation of GTP binding
has_narrow_synonym: activation of GTP binding
has_obo_namespace: biological_process
id: GO:1904426
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of GTP binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of GTP binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:19066305
database_cross_reference: PMID:21454546

Axiom
annotated source: positive regulation of GTP binding
annotated property: has_exact_synonym
annotated target: up regulation of GTP binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of GTP binding
annotated property: has_exact_synonym
annotated target: up-regulation of GTP binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of GTP binding
annotated property: has_exact_synonym
annotated target: upregulation of GTP binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of GTP binding
annotated property: has_narrow_synonym
annotated target: activation of GTP binding
database_cross_reference: GOC:TermGenie

negative regulation of actin filament binding
type: Class
subclass of: negative regulation of protein binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.
created by: als
creation date: 2015-07-30T10:41:55Z
has_exact_synonym: down regulation of F-actin binding
has_exact_synonym: down regulation of actin filament binding
has_exact_synonym: down-regulation of F-actin binding
has_exact_synonym: down-regulation of actin filament binding
has_exact_synonym: downregulation of F-actin binding
has_exact_synonym: downregulation of actin filament binding
has_exact_synonym: negative regulation of F-actin binding
has_narrow_synonym: inhibition of F-actin binding
has_narrow_synonym: inhibition of actin filament binding
has_obo_namespace: biological_process
has_related_synonym: down regulation of actin cross-linking activity
has_related_synonym: down-regulation of actin cross-linking activity
has_related_synonym: downregulation of actin cross-linking activity
has_related_synonym: inhibition of actin cross-linking activity
has_related_synonym: negative regulation of actin cross-linking activity
id: GO:1904530
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of actin filament binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:als
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:24520051

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: down regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: down regulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: down-regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: down-regulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: downregulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: downregulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: negative regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_narrow_synonym
annotated target: inhibition of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_narrow_synonym
annotated target: inhibition of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_related_synonym
annotated target: down regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_related_synonym
annotated target: down-regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_related_synonym
annotated target: downregulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_related_synonym
annotated target: inhibition of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of actin filament binding
annotated property: has_related_synonym
annotated target: negative regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

positive regulation of actin filament binding
type: Class
subclass of: positive regulation of protein binding
definition: Any process that activates or increases the frequency, rate or extent of actin filament binding.
created by: als
creation date: 2015-07-30T10:42:01Z
has_exact_synonym: positive regulation of F-actin binding
has_exact_synonym: up regulation of F-actin binding
has_exact_synonym: up regulation of actin filament binding
has_exact_synonym: up-regulation of F-actin binding
has_exact_synonym: up-regulation of actin filament binding
has_exact_synonym: upregulation of F-actin binding
has_exact_synonym: upregulation of actin filament binding
has_narrow_synonym: activation of F-actin binding
has_narrow_synonym: activation of actin filament binding
has_obo_namespace: biological_process
has_related_synonym: activation of actin cross-linking activity
has_related_synonym: positive regulation of actin cross-linking activity
has_related_synonym: up regulation of actin cross-linking activity
has_related_synonym: up-regulation of actin cross-linking activity
has_related_synonym: upregulation of actin cross-linking activity
id: GO:1904531
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of actin filament binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of actin filament binding.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:als
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:24520051

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: positive regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: up regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: up regulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: up-regulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: up-regulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: upregulation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_exact_synonym
annotated target: upregulation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_narrow_synonym
annotated target: activation of F-actin binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_narrow_synonym
annotated target: activation of actin filament binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_related_synonym
annotated target: activation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_related_synonym
annotated target: positive regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_related_synonym
annotated target: up regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_related_synonym
annotated target: up-regulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of actin filament binding
annotated property: has_related_synonym
annotated target: upregulation of actin cross-linking activity
database_cross_reference: GOC:TermGenie

negative regulation of core promoter binding
type: Class
subclass of: negative regulation of transcription regulatory region DNA binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding.
created by: nc
creation date: 2015-11-09T12:32:31Z
has_exact_synonym: down regulation of core promoter binding
has_exact_synonym: down-regulation of core promoter binding
has_exact_synonym: downregulation of core promoter binding
has_narrow_synonym: inhibition of core promoter binding
has_obo_namespace: biological_process
id: GO:1904797
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of core promoter binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:BHF_telomere
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:nc
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:22723415

Axiom
annotated source: negative regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: down regulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: down-regulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: downregulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of core promoter binding
annotated property: has_narrow_synonym
annotated target: inhibition of core promoter binding
database_cross_reference: GOC:TermGenie

positive regulation of core promoter binding
type: Class
subclass of: positive regulation of transcription regulatory region DNA binding
definition: Any process that activates or increases the frequency, rate or extent of core promoter binding.
created by: nc
creation date: 2015-11-09T12:32:38Z
has_exact_synonym: up regulation of core promoter binding
has_exact_synonym: up-regulation of core promoter binding
has_exact_synonym: upregulation of core promoter binding
has_narrow_synonym: activation of core promoter binding
has_obo_namespace: biological_process
id: GO:1904798
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of core promoter binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of core promoter binding.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:BHF_telomere
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:nc
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:22723415

Axiom
annotated source: positive regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: up regulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: up-regulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of core promoter binding
annotated property: has_exact_synonym
annotated target: upregulation of core promoter binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of core promoter binding
annotated property: has_narrow_synonym
annotated target: activation of core promoter binding
database_cross_reference: GOC:TermGenie

response to haloperidol
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
created by: dw
creation date: 2016-04-08T12:36:39Z
has_obo_namespace: biological_process
id: GO:1905119
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to haloperidol
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:24751813

cellular response to haloperidol
type: Class
subclass of: cellular response to nitrogen compound
subclass of: response to haloperidol
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
created by: dw
creation date: 2016-04-08T12:36:47Z
has_obo_namespace: biological_process
id: GO:1905120
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to haloperidol
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:24751813

positive regulation of RNA binding
type: Class
subclass of: positive regulation of binding
definition: Any process that activates or increases the frequency, rate or extent of RNA binding.
created by: bf
creation date: 2016-06-06T10:21:12Z
has_exact_synonym: up regulation of RNA binding
has_exact_synonym: up-regulation of RNA binding
has_exact_synonym: upregulation of RNA binding
has_narrow_synonym: activation of RNA binding
has_obo_namespace: biological_process
id: GO:1905216
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of RNA binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of RNA binding.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:bf
database_cross_reference: GO_REF:0000059
database_cross_reference: PMID:25116364

Axiom
annotated source: positive regulation of RNA binding
annotated property: has_exact_synonym
annotated target: up regulation of RNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of RNA binding
annotated property: has_exact_synonym
annotated target: up-regulation of RNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of RNA binding
annotated property: has_exact_synonym
annotated target: upregulation of RNA binding
database_cross_reference: GOC:TermGenie

Axiom
annotated source: positive regulation of RNA binding
annotated property: has_narrow_synonym
annotated target: activation of RNA binding
database_cross_reference: GOC:TermGenie

response to temozolomide
type: Class
subclass of: response to nitrogen compound
subclass of: response to oxygen-containing compound
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus.
created by: pr
creation date: 2013-02-22T10:09:44Z
has_obo_namespace: biological_process
id: GO:1990054
in_subset: gocheck do not annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to temozolomide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus.
database_cross_reference: GOC:hp

protein autosumoylation
type: Class
subclass of: peptidyl-amino acid modification
definition: The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
created by: se
creation date: 2014-08-25T22:37:21Z
has_exact_synonym: protein auto-sumoylation
has_exact_synonym: protein self-sumoylation
has_obo_namespace: biological_process
id: GO:1990466
in_subset: gocheck do not annotate

Axiom
annotated source: protein autosumoylation
annotated property: definition
annotated target: The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
database_cross_reference: PMID:21518767
database_cross_reference: PMID:23443663

reproductive senescence
type: Class
subclass of: biological phase
definition: A life cycle stage during which the reproductive capacity and fitness of an organism declines.
term tracker item: https://github.com/geneontology/go-ontology/issues/22733
created by: sl
creation date: 2015-02-10T23:17:56Z
has_narrow_synonym: ovarian senescence
has_obo_namespace: biological_process
id: GO:1990636
in_subset: gocheck do not annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: reproductive senescence
annotated property: definition
annotated target: A life cycle stage during which the reproductive capacity and fitness of an organism declines.
database_cross_reference: PMID:24914937
database_cross_reference: PMID:25523082
database_cross_reference: PMID:27353257

endothelin production
type: Class
subclass of: cytokine production
definition: The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.
created by: sl
creation date: 2015-06-15T23:13:18Z
has_narrow_synonym: EDN1 production
has_narrow_synonym: EDN2 production
has_narrow_synonym: EDN3 production
has_narrow_synonym: endothelin secretion
has_narrow_synonym: endothelin-1 secretion
has_narrow_synonym: endothelin-2 production
has_narrow_synonym: endothelin-3 production
has_obo_namespace: biological_process
id: GO:1990775
in_subset: gocheck do not annotate

Axiom
annotated source: endothelin production
annotated property: definition
annotated target: The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.
database_cross_reference: PMID:15560120

modulation by host of RNA binding by virus
type: Class
subclass of: biological process involved in interspecies interaction between organisms
definition: A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.
created by: bf
creation date: 2016-06-21T11:56:10Z
has_obo_namespace: biological_process
has_related_synonym: modulation by host of viral protein:RNA interaction
id: GO:1990968
in_subset: gocheck do not annotate
comment: Note that the bound RNA may originate from the virus or another organism, including the host.

Axiom
annotated source: modulation by host of RNA binding by virus
annotated property: definition
annotated target: A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.
database_cross_reference: GOC:PARL
database_cross_reference: GOC:bf
database_cross_reference: PMID:25116364

Axiom
annotated source: modulation by host of RNA binding by virus
annotated property: has_related_synonym
annotated target: modulation by host of viral protein:RNA interaction
database_cross_reference: GOC:bf

regulation of reproductive process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: reproductive process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: reproductive process
definition: Any process that modulates the frequency, rate or extent of reproductive process.
created by: mah
creation date: 2010-11-10T02:44:02Z
has_obo_namespace: biological_process
id: GO:2000241
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of reproductive process
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of reproductive process.
database_cross_reference: GOC:mah

regulation of transcription regulatory region DNA binding
type: Class
subclass of: regulation of DNA binding
definition: Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
created by: yaf
creation date: 2011-05-09T03:28:11Z
has_obo_namespace: biological_process
id: GO:2000677
in_subset: gocheck do not annotate

Axiom
annotated source: regulation of transcription regulatory region DNA binding
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.
database_cross_reference: GOC:obol

negative regulation of transcription regulatory region DNA binding
type: Class
subclass of: negative regulation of DNA binding
subclass of: regulation of transcription regulatory region DNA binding
definition: Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
created by: yaf
creation date: 2011-05-09T03:28:14Z
has_obo_namespace: biological_process
id: GO:2000678
in_subset: gocheck do not annotate

Axiom
annotated source: negative regulation of transcription regulatory region DNA binding
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
database_cross_reference: GOC:obol

positive regulation of transcription regulatory region DNA binding
type: Class
subclass of: positive regulation of DNA binding
subclass of: regulation of transcription regulatory region DNA binding
definition: Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
created by: yaf
creation date: 2011-05-09T03:28:17Z
has_obo_namespace: biological_process
id: GO:2000679
in_subset: gocheck do not annotate

Axiom
annotated source: positive regulation of transcription regulatory region DNA binding
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
database_cross_reference: GOC:obol