goslim drosophila.owl
type: Ontology
version IRI: goslim drosophila.owl
version info: 2026-06-29

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

created by
type: AnnotationProperty

creation date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

id
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

mitotic cell cycle
type: Class
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Reactome:R-HSA-69278
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Cell Cycle, Mitotic
type: Axiom
annotated source: mitotic cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69278

cell morphogenesis
type: Class
definition: The developmental process in which the size or shape of a cell is generated and organized.
has_alternative_id: GO:0007148
has_alternative_id: GO:0045790
has_alternative_id: GO:0045791
has_exact_synonym: cellular morphogenesis
has_obo_namespace: biological_process
id: GO:0000902
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: cell morphogenesis
annotated property: definition
annotated target: The developmental process in which the size or shape of a cell is generated and organized.
database_cross_reference: GOC:clt
database_cross_reference: GOC:curators
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

immune system development
type: Class
definition: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
has_obo_namespace: biological_process
id: GO:0002520
in_subset: goslim drosophila

Axiom
annotated source: immune system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
database_cross_reference: GOC:add
database_cross_reference: GOC:dph

muscle system process
type: Class
definition: An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
has_obo_namespace: biological_process
has_related_synonym: muscle physiological process
id: GO:0003012
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: muscle system process
annotated property: definition
annotated target: An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
database_cross_reference: GOC:mtg_cardio

DNA binding
type: Class
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

chromatin binding
type: Class
definition: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has_narrow_synonym: lamin/chromatin binding
has_narrow_synonym: microtubule/chromatin interaction
has_narrow_synonym: nuclear membrane vesicle binding to chromatin
has_obo_namespace: molecular_function
id: GO:0003682
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: chromatin binding
annotated property: definition
annotated target: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:20404130

DNA-binding transcription factor activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: regulation of DNA-templated transcription
subclass of: Restriction
  on property: has part
  some values from: DNA binding
definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/15704
term tracker item: https://github.com/geneontology/go-ontology/issues/16534
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
created by: krc
creation date: 2010-10-21T04:37:54Z
has_alternative_id: GO:0000130
has_alternative_id: GO:0001071
has_alternative_id: GO:0001130
has_alternative_id: GO:0001131
has_alternative_id: GO:0001151
has_alternative_id: GO:0001199
has_alternative_id: GO:0001204
has_broad_synonym: nucleic acid binding transcription factor activity
has_broad_synonym: transcription factor activity
database_cross_reference: Reactome:R-HSA-163666
has_exact_synonym: DNA binding transcription factor activity
has_exact_synonym: gene-specific transcription factor activity
has_exact_synonym: sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has_narrow_synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has_narrow_synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has_narrow_synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
has_obo_namespace: molecular_function
id: GO:0003700
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast
comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.

Axiom
annotated source: DNA-binding transcription factor activity
annotated property: definition
annotated target: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:txnOH-2018

Formation of ChREBP:MLX heterodimer
type: Axiom
annotated source: DNA-binding transcription factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163666

transcription coregulator activity
type: Class
definition: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
term tracker item: https://github.com/geneontology/go-ontology/issues/15536
term tracker item: https://github.com/geneontology/go-ontology/issues/15665
term tracker item: https://github.com/geneontology/go-ontology/issues/15998
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
term tracker item: https://github.com/geneontology/go-ontology/issues/20464
term tracker item: https://github.com/geneontology/go-ontology/issues/20862
term tracker item: https://github.com/geneontology/go-ontology/issues/20962
term tracker item: https://github.com/geneontology/go-ontology/issues/26489
term tracker item: https://github.com/geneontology/go-ontology/issues/28926
term tracker item: https://github.com/geneontology/go-ontology/issues/31471
created by: krc
creation date: 2010-11-24T03:02:15Z
has_alternative_id: GO:0001104
has_alternative_id: GO:0016455
database_cross_reference: Reactome:R-HSA-5340251
has_exact_synonym: transcription cofactor activity
has_exact_synonym: transcription coreceptor activity
has_exact_synonym: transcriptional co-regulator
has_narrow_synonym: nuclear receptor coreceptor activity
has_obo_namespace: molecular_function
has_related_synonym: RNA polymerase II transcriptional cofactor activity
id: GO:0003712
in_subset: goslim drosophila
comment: Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.

Axiom
annotated source: transcription coregulator activity
annotated property: definition
annotated target: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
database_cross_reference: GOC:txnOH-2018
database_cross_reference: PMID:10213677
database_cross_reference: PMID:16858867
database_cross_reference: PMID:24203923
database_cross_reference: PMID:25957681
database_cross_reference: Wikipedia:Transcription_coregulator

NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2
type: Axiom
annotated source: transcription coregulator activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5340251

RNA binding
type: Class
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

structural constituent of ribosome
type: Class
definition: The action of a molecule that contributes to the structural integrity of the ribosome.
has_alternative_id: GO:0003736
has_alternative_id: GO:0003737
has_alternative_id: GO:0003738
has_alternative_id: GO:0003739
has_alternative_id: GO:0003740
has_alternative_id: GO:0003741
has_alternative_id: GO:0003742
has_broad_synonym: ribosomal protein
has_obo_namespace: molecular_function
has_related_synonym: ribosomal RNA
id: GO:0003735
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.

Axiom
annotated source: structural constituent of ribosome
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of the ribosome.
database_cross_reference: GOC:mah

GTPase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
term tracker item: https://github.com/geneontology/go-ontology/issues/26014
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
created by: dph
creation date: 2015-11-11T12:47:56Z
has_alternative_id: GO:0061745
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
database_cross_reference: MetaCyc:RXN0-5462
database_cross_reference: RHEA:19669
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9018814
database_cross_reference: Reactome:R-HSA-9018826
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
database_cross_reference: Reactome:R-HSA-9947842
database_cross_reference: Reactome:R-HSA-9954919
has_narrow_synonym: ARF small monomeric GTPase activity
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation

Axiom
annotated source: GTPase activity
annotated property: definition
annotated target: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
database_cross_reference: PMID:26832457
database_cross_reference: PMID:27218782

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983422

GBP1 hydrolyzes GTP forming GBP1 oligomers
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9947842

ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9954919

nuclease activity
type: Class
definition: Catalysis of the cleavage of ester linkages within nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/24408
has_obo_namespace: molecular_function
id: GO:0004518
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim plant
in_subset: goslim yeast
comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases.

Axiom
annotated source: nuclease activity
annotated property: definition
annotated target: Catalysis of the cleavage of ester linkages within nucleic acids.
database_cross_reference: ISBN:0198547684

guanyl-nucleotide exchange factor activity
type: Class
subclass of: enzyme regulator activity
definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
term tracker item: https://github.com/geneontology/go-ontology/issues/18749
term tracker item: https://github.com/geneontology/go-ontology/issues/18750
term tracker item: https://github.com/geneontology/go-ontology/issues/27684
has_alternative_id: GO:0005086
has_alternative_id: GO:0005087
has_alternative_id: GO:0005088
has_alternative_id: GO:0005089
has_alternative_id: GO:0005090
has_alternative_id: GO:0008321
has_alternative_id: GO:0008433
has_alternative_id: GO:0016219
has_alternative_id: GO:0016220
has_alternative_id: GO:0017034
has_alternative_id: GO:0017112
has_alternative_id: GO:0017132
has_alternative_id: GO:0019839
has_alternative_id: GO:0030676
database_cross_reference: Reactome:R-HSA-109807
database_cross_reference: Reactome:R-HSA-109817
database_cross_reference: Reactome:R-HSA-114544
database_cross_reference: Reactome:R-HSA-1168636
database_cross_reference: Reactome:R-HSA-1225951
database_cross_reference: Reactome:R-HSA-1225957
database_cross_reference: Reactome:R-HSA-1250383
database_cross_reference: Reactome:R-HSA-1250463
database_cross_reference: Reactome:R-HSA-1250498
database_cross_reference: Reactome:R-HSA-1306972
database_cross_reference: Reactome:R-HSA-1433415
database_cross_reference: Reactome:R-HSA-1433471
database_cross_reference: Reactome:R-HSA-156913
database_cross_reference: Reactome:R-HSA-169904
database_cross_reference: Reactome:R-HSA-170979
database_cross_reference: Reactome:R-HSA-171026
database_cross_reference: Reactome:R-HSA-177938
database_cross_reference: Reactome:R-HSA-177945
database_cross_reference: Reactome:R-HSA-180687
database_cross_reference: Reactome:R-HSA-186834
database_cross_reference: Reactome:R-HSA-187746
database_cross_reference: Reactome:R-HSA-194518
database_cross_reference: Reactome:R-HSA-2029445
database_cross_reference: Reactome:R-HSA-2029451
database_cross_reference: Reactome:R-HSA-2029467
database_cross_reference: Reactome:R-HSA-203977
database_cross_reference: Reactome:R-HSA-205039
database_cross_reference: Reactome:R-HSA-210977
database_cross_reference: Reactome:R-HSA-2179407
database_cross_reference: Reactome:R-HSA-2424476
database_cross_reference: Reactome:R-HSA-2424477
database_cross_reference: Reactome:R-HSA-2485180
database_cross_reference: Reactome:R-HSA-2730840
database_cross_reference: Reactome:R-HSA-350769
database_cross_reference: Reactome:R-HSA-354173
database_cross_reference: Reactome:R-HSA-379044
database_cross_reference: Reactome:R-HSA-379048
database_cross_reference: Reactome:R-HSA-380073
database_cross_reference: Reactome:R-HSA-381727
database_cross_reference: Reactome:R-HSA-389348
database_cross_reference: Reactome:R-HSA-389350
database_cross_reference: Reactome:R-HSA-392054
database_cross_reference: Reactome:R-HSA-392195
database_cross_reference: Reactome:R-HSA-3928592
database_cross_reference: Reactome:R-HSA-3928612
database_cross_reference: Reactome:R-HSA-3928628
database_cross_reference: Reactome:R-HSA-3928632
database_cross_reference: Reactome:R-HSA-3928633
database_cross_reference: Reactome:R-HSA-3928642
database_cross_reference: Reactome:R-HSA-3928651
database_cross_reference: Reactome:R-HSA-392870
database_cross_reference: Reactome:R-HSA-3965444
database_cross_reference: Reactome:R-HSA-399938
database_cross_reference: Reactome:R-HSA-399995
database_cross_reference: Reactome:R-HSA-400037
database_cross_reference: Reactome:R-HSA-400092
database_cross_reference: Reactome:R-HSA-4093336
database_cross_reference: Reactome:R-HSA-416530
database_cross_reference: Reactome:R-HSA-416588
database_cross_reference: Reactome:R-HSA-418579

Conversion of Ran-GDP to Ran-GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-180687

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-186834

RIT/RIN are activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-187746

RhoA is activated by nucleotide exchange and inhibits axonal growth
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-194518

An unknown GEF exchanges GTP for GDP on CDC42:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029445

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029451

Activation of RAC1 by CRKII:DOCK180:ELMO
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029467

SAR1 Activation And Membrane Binding
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203977

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205039

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-210977

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2179407

Activation of RAC1 by VAV2/3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424476

SOS mediated nucleotide exchange of RAS (SHC)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424477

MII catalyses GDP/GTP exchange on Gt
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2485180

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2730840

trans-Golgi Network Coat Activation
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350769

Activation of Rap1 by cytosolic GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-354173

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379044

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379048

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380073

RAP1A exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381727

Activation of Rac1 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389348

Activation of Cdc42 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389350

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392054

Gi activation by P2Y purinoceptor 12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392195

p190RhoGEF exchanges GTP for GDP on RHOA, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928592

KALRN exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928612

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928628

ITSN1 exchanges GTP for GDP on CDC42, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928632

bPIX exchanges GTP for GDP on RAC, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928633

TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928642

NGEF exchanges GTP for GDP on RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928651

Gs activation by prostacyclin receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392870

WNT:FZD complex promotes G-protein nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3965444

Activation of Rac1 by FARP2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399938

Muscarinic Acetylcholine Receptor M3 activates Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399995

Gi,Go Heterotrimeric G-protein complex dissociates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400037

Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400092

p-TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4093336

FFAR1:FFAR1 ligands activate Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416530

Activation of Rho by LARG and PDZ-RhoGEF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416588

Gq activation by P2Y purinoceptor 1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418579

Activation of Cdc42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418850

Activation of Rac1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418856

GEFs activate RhoA,B,C
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-419166

Opsins act as GEFs for G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-420883

Activation of RAC1 by SOS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428535

Gq activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428750

G13 activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428917

VAV1 is a GEF for Rho/Rac family GTPases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442273

VAV2 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442291

VAV3 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442314

NMDA-activated RASGRF1 activates RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442732

Activation of Rac1 by VAV2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-445064

VEGF induces CDC42 activation by unknown mechanism
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218829

DOCK180:ELMO exchanges GTP for GDP, activating RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218839

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218850

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5617816

GBF1 stimulates nucleotide exchange on ARF4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623508

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623521

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637806

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637808

Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654392

Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654402

Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654413

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654426

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654600

Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654618

Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654647

Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654663

Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655241

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655277

Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655326

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655347

RAS GEFs promote RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672965

GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686071

GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686318

Nucleotide exchange on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694409

GBF1 stimulates ARF nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807868

GBF1 stimulates nucleotide exchange on ARF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811414

ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811418

RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811429

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-749453

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-751029

Glucagon:GCGR mediates GTP-GDP exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-825631

Activation of RAC1 by the PXN:CRK complex
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848618

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8850041

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851827

RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851877

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851899

RAB3 GEFs exchange GTP for GDP on RAB3A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875318

RAB5 GEFs exchange GTP for GDP on RAB5
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875320

RAPGEF1 activates RAP1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875568

DOCK7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875591

DENND4s exchange GTP for GDP on RAB10
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876188

RAB8 GEFs exchange GTP for GDP on RAB8
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876190

RAB9 GEFs exchange GTP for GDP on RAB9
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876191

RIC1-RGP1 exchanges GTP for GDP on RAB6
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876193

DENND3 exchanges GTP for GDP on RAB12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876454

RAB13 GEFs exchange GTP for GDP on RAB13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876615

DENND6A,B exchange GTP for GDP on RAB14
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876616

RAB21 GEFs exchange GTP for GDP on RAB21
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876837

MADD exchanges GTP for GDP on RAB27
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877308

RAB31 GEFs exchange GTP for GDP on RAB31
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877311

MON1:CCZ1 exchanges GTP for GDP on RAB7
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877451

TRAPPC complexes exchange GTP for GDP on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877475

DENND1s exchange GTP for GDP on RAB35
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877612

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877760

DENND5A,B exchange GTP for GDP on RAB39
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877813

RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877998

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8964604

RHOA GEFs activate RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8980691

Opsins binds G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982637

G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982640

RHOB GEFs activate RHOB
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013023

RHOC GEFs activate RHOC
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013109

RAC1 GEFs activate RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013143

CDC42 GEFs activate CDC42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013159

RHOD auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013435

RAC2 GEFs activate RAC2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014296

RHOG GEFs activate RHOG
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014433

RHOJ GEFs activate RHOJ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9017491

RHOQ GEFs activate RHOQ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018747

RHOU auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018768

RAC3 GEFs activate RAC3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018804

RHOT1 GEFs activate RHOT1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018817

RHOT2 GEFs activate RHOT2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018825

NTRK2 activates RAS signaling through SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026891

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9029158

NTRK2 activates RAS signaling through FRS2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032067

DOCK3 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032798

NTRK2 and CDK5 promote activation of RAC1 by TIAM1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033292

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9036301

Activation of Rap1 by membrane-associated GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-939265

SOS1-mediated nucleotide exchange of RAS downstream of FLT3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9607304

p-S516-ARHGEF7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9619803

RCC1 stimulates GDP to GTP exchange on RAN
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9624845

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9634418

RRAGC,D exchanges GTP for GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9639286

RRAGA,B exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640167

ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9660824

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9664991

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665009

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665404

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665408

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665700

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665707

DOCK180 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666428

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666430

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9670436

SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672163

SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672170

CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9680385

RHOF auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693111

FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9695853

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9703441

p-VAV1,2,3 exchange 6TGTP for GDP on RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9751201

SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9970163

Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: definition
annotated target: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
database_cross_reference: GOC:kd
database_cross_reference: GOC:mah
database_cross_reference: PMID:23303910
database_cross_reference: PMID:27218782

GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109807

GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109817

p115-RhoGEF activation of RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114544

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1168636

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225951

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225957

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250383

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250463

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250498

RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1306972

Activation of RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433415

Activation of RAS by p-KIT bound SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433471

Regeneration of eEF1A:GTP by eEF1B activity
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156913

C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169904

(Frs2)C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170979

Guanine nucleotide exchange on RAL
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-171026

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177938

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177945

structural constituent of cytoskeleton
type: Class
subclass of: Restriction
  on property: part of
  some values from: cytoskeleton organization
subclass of: Restriction
  on property: occurs in
  some values from: cytoskeleton
definition: The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
has_obo_namespace: molecular_function
id: GO:0005200
in_subset: goslim drosophila

Axiom
annotated source: structural constituent of cytoskeleton
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
database_cross_reference: GOC:mah

extracellular matrix structural constituent
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: extracellular region
subclass of: Restriction
  on property: occurs in
  some values from: extracellular matrix
definition: The action of a molecule that contributes to the structural integrity of the extracellular matrix.
has_broad_synonym: core extracellular matrix
has_broad_synonym: core matrisome
has_narrow_synonym: extracellular matrix glycoprotein
has_obo_namespace: molecular_function
id: GO:0005201
in_subset: goslim drosophila
comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019

Axiom
annotated source: extracellular matrix structural constituent
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of the extracellular matrix.
database_cross_reference: GOC:mah

extracellular region
type: Class
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
term tracker item: https://github.com/geneontology/go-ontology/issues/31545
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:curators

nucleus
type: Class
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

chromosome
type: Class
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: Wikipedia:Chromosome
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
id: GO:0005694
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684

nucleolus
type: Class
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
id: GO:0005730
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleolus
annotated property: definition
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732

mitochondrion
type: Class
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

endosome
type: Class
definition: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: NIF_Subcellular:sao1720343330
database_cross_reference: Wikipedia:Endosome
has_obo_namespace: cellular_component
id: GO:0005768
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: endosome
annotated property: definition
annotated target: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:19696797

vacuole
type: Class
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

peroxisome
type: Class
definition: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
has_alternative_id: GO:0019818
has_broad_synonym: peroxisome vesicle
database_cross_reference: NIF_Subcellular:sao499555322
database_cross_reference: Wikipedia:Peroxisome
has_obo_namespace: cellular_component
has_related_synonym: peroxisomal
id: GO:0005777
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: peroxisome
annotated property: definition
annotated target: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
database_cross_reference: GOC:pm
database_cross_reference: PMID:9302272
database_cross_reference: UniProtKB-KW:KW-0576

endoplasmic reticulum
type: Class
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
term tracker item: https://github.com/geneontology/go-ontology/issues/14798
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:9695800

cytosol
type: Class
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
id: GO:0005829
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cytosol
annotated property: definition
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:jl

cytoskeleton
type: Class
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

cilium
type: Class
definition: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
has_alternative_id: GO:0072372
database_cross_reference: FMA:67181
database_cross_reference: NIF_Subcellular:sao787716553
database_cross_reference: Wikipedia:Cilium
has_exact_synonym: eukaryotic flagellum
has_exact_synonym: microtubule-based flagellum
has_narrow_synonym: primary cilium
has_obo_namespace: cellular_component
has_related_synonym: flagellum
id: GO:0005929
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.

Axiom
annotated source: cilium
annotated property: definition
annotated target: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:curators
database_cross_reference: GOC:kmv
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16824949
database_cross_reference: PMID:17009929
database_cross_reference: PMID:20144998

carbohydrate metabolic process
type: Class
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
term tracker item: https://github.com/geneontology/go-ontology/issues/22880
created by: jl
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

alcohol metabolic process
type: Class
definition: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
term tracker item: https://github.com/geneontology/go-ontology/issues/31485
has_exact_synonym: alcohol metabolism
has_obo_namespace: biological_process
id: GO:0006066
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: alcohol metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
database_cross_reference: ISBN:0198506732

pyruvate metabolic process
type: Class
definition: The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
term tracker item: https://github.com/geneontology/go-ontology/issues/29541
term tracker item: https://github.com/geneontology/go-ontology/issues/31634
has_alternative_id: GO:0006087
database_cross_reference: Wikipedia:Pyruvic_acid
has_exact_synonym: pyruvate metabolism
has_obo_namespace: biological_process
has_related_synonym: pyruvate dehydrogenase bypass
id: GO:0006090
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: pyruvate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
database_cross_reference: GOC:curators

generation of precursor metabolites and energy
type: Class
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
has_broad_synonym: energy pathways
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
has_related_synonym: metabolic energy generation
id: GO:0006091
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
database_cross_reference: GOC:jl

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

DNA replication
type: Class
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
term tracker item: https://github.com/geneontology/go-ontology/issues/10596
has_alternative_id: GO:0055133
database_cross_reference: Reactome:R-HSA-176187
database_cross_reference: Reactome:R-HSA-69239
database_cross_reference: Wikipedia:DNA_replication
has_obo_namespace: biological_process
id: GO:0006260
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.

Axiom
annotated source: DNA replication
annotated property: definition
annotated target: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
database_cross_reference: GOC:mah

Activation of ATR in response to replication stress
type: Axiom
annotated source: DNA replication
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176187

Synthesis of DNA
type: Axiom
annotated source: DNA replication
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69239

DNA repair
type: Class
subclass of: response to stress
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Reactome:R-HSA-73894
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
id: GO:0006281
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA repair
annotated property: definition
annotated target: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: PMID:11563486

DNA Repair
type: Axiom
annotated source: DNA repair
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73894

DNA recombination
type: Class
definition: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
has_obo_namespace: biological_process
id: GO:0006310
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: DNA recombination
annotated property: definition
annotated target: Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
database_cross_reference: ISBN:0198506732

DNA-templated transcription
type: Class
definition: The synthesis of an RNA transcript from a DNA template.
term tracker item: https://github.com/geneontology/go-ontology/issues/14854
term tracker item: https://github.com/geneontology/go-ontology/issues/16737
term tracker item: https://github.com/geneontology/go-ontology/issues/22258
term tracker item: https://github.com/geneontology/go-ontology/issues/22555
has_alternative_id: GO:0001121
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database_cross_reference: Reactome:R-HSA-2173793
database_cross_reference: Reactome:R-HSA-74160
database_cross_reference: Wikipedia:Transcription_(genetics)
has_exact_synonym: DNA-dependent transcription
has_exact_synonym: transcription, DNA-dependent
has_exact_synonym: transcription, DNA-templated
has_narrow_synonym: bacterial transcription
has_narrow_synonym: transcription from bacterial-type RNA polymerase promoter
has_obo_namespace: biological_process
id: GO:0006351
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: DNA-templated transcription
annotated property: definition
annotated target: The synthesis of an RNA transcript from a DNA template.
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
type: Axiom
annotated source: DNA-templated transcription
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2173793

Gene expression (Transcription)
type: Axiom
annotated source: DNA-templated transcription
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-74160

Axiom
annotated source: DNA-templated transcription
annotated property: has_exact_synonym
annotated target: transcription, DNA-dependent
database_cross_reference: GOC:txnOH

regulation of DNA-templated transcription
type: Class
subclass of: Restriction
  on property: regulates
  some values from: DNA-templated transcription
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/25256
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_broad_synonym: transcriptional control
database_cross_reference: Reactome:R-HSA-9013695
database_cross_reference: Reactome:R-HSA-9708530
database_cross_reference: Reactome:R-HSA-9762293
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-dependent
has_exact_synonym: regulation of transcription, DNA-templated
has_obo_namespace: biological_process
has_related_synonym: regulation of gene-specific transcription
id: GO:0006355
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
database_cross_reference: GOC:curators
database_cross_reference: GOC:txnOH

NOTCH4 Intracellular Domain Regulates Transcription
type: Axiom
annotated source: regulation of DNA-templated transcription
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013695

Regulation of BACH1 activity
type: Axiom
annotated source: regulation of DNA-templated transcription
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9708530

Regulation of CDH11 gene transcription
type: Axiom
annotated source: regulation of DNA-templated transcription
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9762293

Axiom
annotated source: regulation of DNA-templated transcription
annotated property: has_exact_synonym
annotated target: regulation of transcription, DNA-dependent
database_cross_reference: GOC:txnOH

RNA processing
type: Class
definition: Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
has_alternative_id: GO:0006394
database_cross_reference: Wikipedia:Post-transcriptional_modification
has_obo_namespace: biological_process
id: GO:0006396
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: RNA processing
annotated property: definition
annotated target: Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
database_cross_reference: GOC:mah

tRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
has_exact_synonym: tRNA metabolism
has_obo_namespace: biological_process
id: GO:0006399
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: tRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
database_cross_reference: ISBN:0198506732

RNA localization
type: Class
definition: A process in which RNA is transported to, or maintained in, a specific location.
has_exact_synonym: RNA localisation
has_exact_synonym: establishment and maintenance of RNA localization
has_obo_namespace: biological_process
id: GO:0006403
in_subset: goslim drosophila

Axiom
annotated source: RNA localization
annotated property: definition
annotated target: A process in which RNA is transported to, or maintained in, a specific location.
database_cross_reference: GOC:ai

Axiom
annotated source: RNA localization
annotated property: has_exact_synonym
annotated target: RNA localisation
database_cross_reference: GOC:mah

translation
type: Class
subclass of: Restriction
  on property: has part
  some values from: acyltransferase activity
subclass of: Restriction
  on property: has part
  some values from: protein-containing complex assembly
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
database_cross_reference: Reactome:R-HSA-72766
database_cross_reference: Wikipedia:Translation_(genetics)
has_exact_synonym: protein translation
has_obo_namespace: biological_process
id: GO:0006412
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation
annotated property: definition
annotated target: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: GOC:curators

Translation
type: Axiom
annotated source: translation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72766

protein folding
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein maturation
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
term tracker item: https://github.com/geneontology/go-ontology/issues/25673
has_alternative_id: GO:0007022
has_alternative_id: GO:0007024
has_alternative_id: GO:0007025
database_cross_reference: Reactome:R-HSA-389960
database_cross_reference: Reactome:R-HSA-390450
database_cross_reference: Reactome:R-HSA-390466
database_cross_reference: Reactome:R-HSA-532668
database_cross_reference: Wikipedia:Protein_folding
has_narrow_synonym: alpha-tubulin folding
has_narrow_synonym: beta-tubulin folding
has_narrow_synonym: chaperonin-mediated tubulin folding
has_obo_namespace: biological_process
has_related_synonym: chaperone activity
has_related_synonym: chaperonin ATPase activity
has_related_synonym: co-chaperone activity
has_related_synonym: co-chaperonin activity
has_related_synonym: glycoprotein-specific chaperone activity
has_related_synonym: non-chaperonin molecular chaperone ATPase activity
has_related_synonym: protein complex assembly, multichaperone pathway
id: GO:0006457
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: protein folding
annotated property: definition
annotated target: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: GOC:curators
database_cross_reference: GOC:rb

Formation of tubulin folding intermediates by CCT/TriC
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389960

Folding of actin by CCT/TriC
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390450

Chaperonin-mediated protein folding
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390466

N-glycan trimming in the ER and Calnexin/Calreticulin cycle
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-532668

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: alpha-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: beta-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: chaperonin-mediated tubulin folding
database_cross_reference: GOC:mah

protein lipidation
type: Class
definition: The covalent attachment of lipid groups to an amino acid in a protein.
has_alternative_id: GO:0042050
database_cross_reference: RESID:AA0059
database_cross_reference: RESID:AA0060
database_cross_reference: RESID:AA0077
database_cross_reference: RESID:AA0078
database_cross_reference: RESID:AA0079
database_cross_reference: RESID:AA0080
database_cross_reference: RESID:AA0102
database_cross_reference: RESID:AA0103
database_cross_reference: RESID:AA0104
database_cross_reference: RESID:AA0106
database_cross_reference: RESID:AA0107
database_cross_reference: RESID:AA0158
database_cross_reference: RESID:AA0159
database_cross_reference: RESID:AA0160
database_cross_reference: RESID:AA0161
database_cross_reference: RESID:AA0162
database_cross_reference: RESID:AA0163
database_cross_reference: RESID:AA0166
database_cross_reference: RESID:AA0223
database_cross_reference: RESID:AA0290
database_cross_reference: RESID:AA0307
database_cross_reference: RESID:AA0308
database_cross_reference: RESID:AA0309
database_cross_reference: RESID:AA0316
has_exact_synonym: lipid:protein modification
has_exact_synonym: protein amino acid lipidation
has_obo_namespace: biological_process
id: GO:0006497
in_subset: gocheck obsoletion candidate
in_subset: goslim drosophila
comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children.

Axiom
annotated source: protein lipidation
annotated property: definition
annotated target: The covalent attachment of lipid groups to an amino acid in a protein.
database_cross_reference: GOC:jl

Axiom
annotated source: protein lipidation
annotated property: has_exact_synonym
annotated target: protein amino acid lipidation
database_cross_reference: GOC:bf

amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
term tracker item: https://github.com/geneontology/go-ontology/issues/17904
has_alternative_id: GO:0006519
has_exact_synonym: cellular amino acid metabolic process
has_exact_synonym: cellular amino acid metabolism
has_obo_namespace: biological_process
has_related_synonym: amino acid and derivative metabolism
has_related_synonym: cellular amino acid and derivative metabolic process
id: GO:0006520
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
database_cross_reference: ISBN:0198506732

modified amino acid metabolic process
type: Class
definition: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
term tracker item: https://github.com/geneontology/go-ontology/issues/28908
has_exact_synonym: amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolic process
has_exact_synonym: cellular amino acid derivative metabolism
has_exact_synonym: cellular modified amino acid metabolic process
has_exact_synonym: cellular modified amino acid metabolism
has_exact_synonym: modified amino acid metabolism
has_obo_namespace: biological_process
id: GO:0006575
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: modified amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
database_cross_reference: GOC:ai

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolic process
database_cross_reference: GOC:mah

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: cellular modified amino acid metabolism
database_cross_reference: GOC:mah

Axiom
annotated source: modified amino acid metabolic process
annotated property: has_exact_synonym
annotated target: modified amino acid metabolism
database_cross_reference: GOC:mah

polyamine metabolic process
type: Class
definition: The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.
database_cross_reference: Reactome:R-HSA-351202
has_exact_synonym: polyamine metabolism
has_obo_namespace: biological_process
id: GO:0006595
in_subset: goslim drosophila
in_subset: goslim pombe

Axiom
annotated source: polyamine metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.
database_cross_reference: ISBN:0198506732

Metabolism of polyamines
type: Axiom
annotated source: polyamine metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-351202

lipid metabolic process
type: Class
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Reactome:R-HSA-556833
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

Metabolism of lipids
type: Axiom
annotated source: lipid metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-556833

ubiquinone biosynthetic process
type: Class
definition: The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
database_cross_reference: MetaCyc:UBISYN-PWY
database_cross_reference: Reactome:R-HSA-2142789
has_exact_synonym: coenzyme Q biosynthesis
has_exact_synonym: coenzyme Q biosynthetic process
has_exact_synonym: ubiquinone anabolism
has_exact_synonym: ubiquinone biosynthesis
has_exact_synonym: ubiquinone formation
has_exact_synonym: ubiquinone synthesis
has_narrow_synonym: coenzyme Q10 biosynthesis
has_narrow_synonym: coenzyme Q10 biosynthetic process
has_narrow_synonym: coenzyme Q6 biosynthesis
has_narrow_synonym: coenzyme Q6 biosynthetic process
has_narrow_synonym: coenzyme Q8 biosynthesis
has_narrow_synonym: coenzyme Q8 biosynthetic process
has_narrow_synonym: coenzyme Q9 biosynthesis
has_narrow_synonym: coenzyme Q9 biosynthetic process
has_obo_namespace: biological_process
id: GO:0006744
in_subset: goslim drosophila
in_subset: goslim pombe

Axiom
annotated source: ubiquinone biosynthetic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
database_cross_reference: GOC:mah

Ubiquinol biosynthesis
type: Axiom
annotated source: ubiquinone biosynthetic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2142789

vitamin metabolic process
type: Class
definition: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: Reactome:R-HSA-211916
has_exact_synonym: vitamin metabolism
has_obo_namespace: biological_process
id: GO:0006766
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: vitamin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
database_cross_reference: GOC:ai

Vitamins
type: Axiom
annotated source: vitamin metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-211916

sulfur compound metabolic process
type: Class
definition: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: Wikipedia:Sulfur_metabolism
has_exact_synonym: sulfur metabolism
has_exact_synonym: sulphur metabolic process
has_exact_synonym: sulphur metabolism
has_obo_namespace: biological_process
id: GO:0006790
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: sulfur compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: GOC:ai

monoatomic ion transport
type: Class
definition: The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
has_broad_synonym: ion transport
has_obo_namespace: biological_process
id: GO:0006811
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: monoatomic ion transport
annotated property: definition
annotated target: The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
database_cross_reference: GOC:ai

mitochondrial transport
type: Class
definition: Transport of substances into, out of or within a mitochondrion.
term tracker item: https://github.com/geneontology/go-ontology/issues/22316
has_obo_namespace: biological_process
id: GO:0006839
in_subset: goslim drosophila

Axiom
annotated source: mitochondrial transport
annotated property: definition
annotated target: Transport of substances into, out of or within a mitochondrion.
database_cross_reference: GOC:ai

lipid transport
type: Class
definition: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: Reactome:R-HSA-1369062
has_obo_namespace: biological_process
id: GO:0006869
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: lipid transport
annotated property: definition
annotated target: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
database_cross_reference: ISBN:0198506732

ABC transporters in lipid homeostasis
type: Axiom
annotated source: lipid transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1369062

nucleocytoplasmic transport
type: Class
definition: The directed movement of molecules between the nucleus and the cytoplasm.
has_alternative_id: GO:0000063
has_narrow_synonym: nucleocytoplasmic shuttling
has_obo_namespace: biological_process
id: GO:0006913
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.

Axiom
annotated source: nucleocytoplasmic transport
annotated property: definition
annotated target: The directed movement of molecules between the nucleus and the cytoplasm.
database_cross_reference: GOC:curators

autophagy
type: Class
subclass of: Restriction
  on property: has part
  some values from: transmembrane transport
definition: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
term tracker item: https://github.com/geneontology/go-ontology/issues/25541
has_alternative_id: GO:0016238
database_cross_reference: Reactome:R-HSA-9612973
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
id: GO:0006914
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: autophagy
annotated property: definition
annotated target: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
database_cross_reference: GOC:autophagy
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:11099404
database_cross_reference: PMID:29455577
database_cross_reference: PMID:9412464

Autophagy
type: Axiom
annotated source: autophagy
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9612973

response to stress
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
term tracker item: https://github.com/geneontology/go-ontology/issues/26810
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
id: GO:0006950
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

immune response
type: Class
definition: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
has_obo_namespace: biological_process
id: GO:0006955
in_subset: goslim drosophila

Axiom
annotated source: immune response
annotated property: definition
annotated target: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

nucleus organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
has_alternative_id: GO:0048287
has_exact_synonym: nuclear organisation
has_exact_synonym: nuclear organization
has_obo_namespace: biological_process
has_related_synonym: nuclear morphology
has_related_synonym: nuclear organization and biogenesis
has_related_synonym: nucleus organization and biogenesis
id: GO:0006997
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: nucleus organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nuclear organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: nucleus organization
annotated property: has_related_synonym
annotated target: nucleus organization and biogenesis
database_cross_reference: GOC:mah

mitochondrion organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: Reactome:R-HSA-1592230
has_exact_synonym: mitochondria organization
has_exact_synonym: mitochondrial biogenesis
has_exact_synonym: mitochondrial organization
has_exact_synonym: mitochondrion biogenesis
has_exact_synonym: mitochondrion organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrion morphogenesis
has_related_synonym: mitochondrion organization and biogenesis
id: GO:0007005
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: mitochondrion organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:sgd_curators
database_cross_reference: PMID:9786946

Mitochondrial biogenesis
type: Axiom
annotated source: mitochondrion organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592230

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondria organization
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondrion organisation
database_cross_reference: GOC:mah

cytoskeleton organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

microtubule-based movement
type: Class
definition: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
database_cross_reference: Reactome:R-HSA-983189
has_obo_namespace: biological_process
id: GO:0007018
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: microtubule-based movement
annotated property: definition
annotated target: A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
database_cross_reference: GOC:cjm
database_cross_reference: ISBN:0815316194

Kinesins
type: Axiom
annotated source: microtubule-based movement
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983189

peroxisome organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
has_exact_synonym: peroxisome organisation
has_obo_namespace: biological_process
has_related_synonym: peroxisome organization and biogenesis
id: GO:0007031
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: peroxisome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
database_cross_reference: GOC:mah

Axiom
annotated source: peroxisome organization
annotated property: has_related_synonym
annotated target: peroxisome organization and biogenesis
database_cross_reference: GOC:mah

vacuole organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
has_alternative_id: GO:0044086
has_exact_synonym: vacuole organisation
has_narrow_synonym: vacuolar assembly
has_obo_namespace: biological_process
has_related_synonym: vacuole biogenesis
has_related_synonym: vacuole organization and biogenesis
id: GO:0007033
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: vacuole organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_narrow_synonym
annotated target: vacuolar assembly
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: vacuole organization
annotated property: has_related_synonym
annotated target: vacuole organization and biogenesis
database_cross_reference: GOC:mah

chromosome segregation
type: Class
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

cell adhesion
type: Class
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
created by: dos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion
annotated property: definition
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf

establishment or maintenance of cell polarity
type: Class
definition: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
has_alternative_id: GO:0030012
has_alternative_id: GO:0030467
has_obo_namespace: biological_process
has_related_synonym: cell polarity
has_related_synonym: establishment and/or maintenance of cell polarity
has_related_synonym: establishment and/or maintenance of cell polarization
id: GO:0007163
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: definition
annotated target: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
database_cross_reference: GOC:mah

Axiom
annotated source: establishment or maintenance of cell polarity
annotated property: has_related_synonym
annotated target: cell polarity
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

cell surface receptor signaling pathway
type: Class
definition: The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
database_cross_reference: Reactome:R-HSA-73887
has_exact_synonym: cell surface receptor linked signal transduction
has_exact_synonym: cell surface receptor linked signaling pathway
has_exact_synonym: cell surface receptor linked signalling pathway
has_obo_namespace: biological_process
id: GO:0007166
in_subset: goslim drosophila

Axiom
annotated source: cell surface receptor signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
database_cross_reference: GOC:signaling

Death Receptor Signaling
type: Axiom
annotated source: cell surface receptor signaling pathway
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73887

Axiom
annotated source: cell surface receptor signaling pathway
annotated property: has_exact_synonym
annotated target: cell surface receptor linked signaling pathway
database_cross_reference: GOC:bf

Axiom
annotated source: cell surface receptor signaling pathway
annotated property: has_exact_synonym
annotated target: cell surface receptor linked signalling pathway
database_cross_reference: GOC:mah

G protein-coupled receptor signaling pathway
type: Class
subclass of: Restriction
  on property: has part
  some values from: signaling receptor activity
definition: The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
has_alternative_id: GO:0038042
database_cross_reference: Reactome:R-HSA-373076
database_cross_reference: Reactome:R-HSA-388396
has_exact_synonym: G protein coupled receptor protein signaling pathway
has_exact_synonym: G protein coupled receptor protein signalling pathway
has_exact_synonym: G-protein coupled receptor protein signal transduction
has_exact_synonym: G-protein coupled receptor protein signaling pathway
has_exact_synonym: G-protein coupled receptor signalling pathway
has_exact_synonym: G-protein-coupled receptor protein signalling pathway
has_exact_synonym: GPCR signaling pathway
has_exact_synonym: GPCR signalling pathway
has_narrow_synonym: G-protein coupled receptor signaling pathway via GPCR dimer
has_narrow_synonym: dimeric G-protein coupled receptor signaling pathway
has_narrow_synonym: dimeric G-protein coupled receptor signalling pathway
has_obo_namespace: biological_process
id: GO:0007186
in_subset: goslim drosophila

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: definition
annotated target: The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah
database_cross_reference: PMID:16902576
database_cross_reference: PMID:24568158
database_cross_reference: Wikipedia:G_protein-coupled_receptor

Class A/1 (Rhodopsin-like receptors)
type: Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-373076

GPCR downstream signalling
type: Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-388396

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_exact_synonym
annotated target: G-protein coupled receptor protein signaling pathway
database_cross_reference: GOC:bf

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_narrow_synonym
annotated target: G-protein coupled receptor signaling pathway via GPCR dimer
database_cross_reference: GOC:bf

Axiom
annotated source: G protein-coupled receptor signaling pathway
annotated property: has_narrow_synonym
annotated target: dimeric G-protein coupled receptor signalling pathway
database_cross_reference: GOC:mah

gastrulation
type: Class
definition: A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
database_cross_reference: Reactome:R-HSA-9758941
database_cross_reference: Wikipedia:Gastrulation
has_obo_namespace: biological_process
id: GO:0007369
in_subset: goslim drosophila

Axiom
annotated source: gastrulation
annotated property: definition
annotated target: A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:9780878933846

Gastrulation
type: Axiom
annotated source: gastrulation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9758941

pattern specification process
type: Class
definition: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
has_obo_namespace: biological_process
has_related_synonym: pattern biosynthesis
has_related_synonym: pattern formation
id: GO:0007389
in_subset: goslim drosophila

Axiom
annotated source: pattern specification process
annotated property: definition
annotated target: Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
database_cross_reference: GOC:curators
database_cross_reference: GOC:isa_complete
database_cross_reference: ISBN:0521436125

nervous system development
type: Class
definition: The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
database_cross_reference: Reactome:R-HSA-9675108
has_obo_namespace: biological_process
has_related_synonym: pan-neural process
id: GO:0007399
in_subset: goslim drosophila

Axiom
annotated source: nervous system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
database_cross_reference: GOC:dgh

Nervous system development
type: Axiom
annotated source: nervous system development
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9675108

sensory organ development
type: Class
definition: The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
has_exact_synonym: sense organ development
has_obo_namespace: biological_process
id: GO:0007423
in_subset: goslim drosophila

Axiom
annotated source: sensory organ development
annotated property: definition
annotated target: The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
database_cross_reference: GOC:curators

Axiom
annotated source: sensory organ development
annotated property: has_exact_synonym
annotated target: sense organ development
database_cross_reference: GOC:dph

salivary gland development
type: Class
definition: The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
has_obo_namespace: biological_process
id: GO:0007431
in_subset: goslim drosophila

Axiom
annotated source: salivary gland development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
database_cross_reference: GOC:jid
database_cross_reference: UBERON:0001044

mesoderm development
type: Class
definition: The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
has_obo_namespace: biological_process
id: GO:0007498
in_subset: goslim drosophila

Axiom
annotated source: mesoderm development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

sensory perception
type: Class
definition: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
database_cross_reference: Reactome:R-HSA-9709957
database_cross_reference: Wikipedia:Perception
has_obo_namespace: biological_process
id: GO:0007600
in_subset: goslim drosophila

Axiom
annotated source: sensory perception
annotated property: definition
annotated target: The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph

Sensory Perception
type: Axiom
annotated source: sensory perception
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9709957

circadian rhythm
type: Class
definition: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
has_alternative_id: GO:0050895
database_cross_reference: Reactome:R-HSA-9909396
database_cross_reference: Wikipedia:Circadian_rhythm
has_exact_synonym: circadian process
has_obo_namespace: biological_process
has_related_synonym: circadian response
has_related_synonym: response to circadian rhythm
id: GO:0007623
in_subset: goslim drosophila
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: circadian rhythm
annotated property: definition
annotated target: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
database_cross_reference: GOC:bf
database_cross_reference: GOC:curators

Circadian clock
type: Axiom
annotated source: circadian rhythm
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9909396

locomotory behavior
type: Class
definition: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
has_exact_synonym: behavior via locomotion
has_exact_synonym: locomotion in response to stimulus
has_exact_synonym: locomotory behavioral response to stimulus
has_exact_synonym: locomotory behaviour
has_exact_synonym: locomotory behavioural response to stimulus
has_obo_namespace: biological_process
id: GO:0007626
in_subset: goslim drosophila

Axiom
annotated source: locomotory behavior
annotated property: definition
annotated target: The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
database_cross_reference: GOC:dph

chitin binding
type: Class
definition: Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
has_obo_namespace: molecular_function
id: GO:0008061
in_subset: goslim drosophila

Axiom
annotated source: chitin binding
annotated property: definition
annotated target: Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

cytoskeletal protein binding
type: Class
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

intracellular protein localization
type: Class
definition: Any process in which a protein is transported to, or maintained in, a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0008105
has_alternative_id: GO:0016249
has_alternative_id: GO:0034613
has_broad_synonym: protein localization
database_cross_reference: Reactome:R-HSA-9609507
has_exact_synonym: cellular protein localisation
has_exact_synonym: cellular protein localization
has_exact_synonym: protein localisation
has_narrow_synonym: channel localizer activity
has_obo_namespace: biological_process
has_related_synonym: asymmetric protein localisation
has_related_synonym: asymmetric protein localization
has_related_synonym: establishment and maintenance of asymmetric protein localization
has_related_synonym: establishment and maintenance of protein localization
id: GO:0008104
in_subset: goslim drosophila

Axiom
annotated source: intracellular protein localization
annotated property: definition
annotated target: Any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:ai

Protein localization
type: Axiom
annotated source: intracellular protein localization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9609507

Axiom
annotated source: intracellular protein localization
annotated property: has_exact_synonym
annotated target: cellular protein localisation
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein localization
annotated property: has_exact_synonym
annotated target: protein localisation
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein localization
annotated property: has_narrow_synonym
annotated target: channel localizer activity
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular protein localization
annotated property: has_related_synonym
annotated target: asymmetric protein localisation
database_cross_reference: GOC:mah

transcription factor binding
type: Class
definition: Binding to a transcription factor, a protein required to initiate or regulate transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/19354
has_exact_synonym: TF binding
has_obo_namespace: molecular_function
has_related_synonym: transcription regulator binding
id: GO:0008134
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.

Axiom
annotated source: transcription factor binding
annotated property: definition
annotated target: Binding to a transcription factor, a protein required to initiate or regulate transcription.
database_cross_reference: ISBN:0198506732

methyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a methyl group to an acceptor molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0004480
has_broad_synonym: methylase
database_cross_reference: EC:2.1.1.-
database_cross_reference: Reactome:R-HSA-212269
database_cross_reference: Reactome:R-HSA-379387
database_cross_reference: Reactome:R-HSA-379464
database_cross_reference: Reactome:R-HSA-5333608
database_cross_reference: Reactome:R-HSA-6800149
database_cross_reference: Reactome:R-HSA-71286
database_cross_reference: Reactome:R-HSA-9710490
has_obo_namespace: molecular_function
id: GO:0008168
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: methyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a methyl group to an acceptor molecule.
database_cross_reference: ISBN:0198506732

DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-212269

COMT transfers Met to DA to form 3MT
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379387

COMT transfers Met to DOPAC to form HVA
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379464

GSSebGalNac is reduced and methylated to MeSebGalNac
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333608

N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800149

guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-71286

The GSDME gene promoter is hypermethylated
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9710490

peptidase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0070010
has_alternative_id: GO:0070011
database_cross_reference: EC:3.4.-.-
database_cross_reference: Reactome:R-HSA-205112
database_cross_reference: Reactome:R-HSA-3000243
database_cross_reference: Reactome:R-HSA-3000263
database_cross_reference: Reactome:R-HSA-3065958
database_cross_reference: Reactome:R-HSA-3065959
database_cross_reference: Reactome:R-HSA-3139027
database_cross_reference: Reactome:R-HSA-376149
database_cross_reference: Reactome:R-HSA-4167501
database_cross_reference: Reactome:R-HSA-448678
database_cross_reference: Reactome:R-HSA-5655483
database_cross_reference: Reactome:R-HSA-5684864
database_cross_reference: Reactome:R-HSA-5685902
database_cross_reference: Reactome:R-HSA-6803060
database_cross_reference: Reactome:R-HSA-9935547
has_exact_synonym: hydrolase, acting on peptide bonds
has_exact_synonym: peptide hydrolase activity
has_exact_synonym: protease activity
has_narrow_synonym: peptidase activity, acting on D-amino acid peptides
has_narrow_synonym: peptidase activity, acting on L-amino acid peptides
has_narrow_synonym: proteinase activity
has_obo_namespace: molecular_function
id: GO:0008233
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: peptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
database_cross_reference: EC:3.4.-.-
database_cross_reference: GOC:jl

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205112

Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000243

TCN2:RCbl is degraded to release RCbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000263

An unknown protease degrades ACACA
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065958

An unknown protease degrades hCBXs
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065959

Maturation of HIV Virion
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3139027

Proteolytic processing of SLIT
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376149

An unknown protease degrades ACACB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4167501

CTSG cleaves CASP1(1-404)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-448678

USP1 autocleavage
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655483

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5684864

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5685902

DCD(63-110) is processed to DCD(63-109)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6803060

Lysosomal degradation of ubiquitinated CDH1
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9935547

cell population proliferation
type: Class
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
has_obo_namespace: biological_process
has_related_synonym: cell proliferation
id: GO:0008283
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.

Axiom
annotated source: cell population proliferation
annotated property: definition
annotated target: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mb

lipid binding
type: Class
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

glycoprotein metabolic process
type: Class
definition: The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
has_exact_synonym: glycoprotein metabolism
has_obo_namespace: biological_process
id: GO:0009100
in_subset: goslim drosophila

Axiom
annotated source: glycoprotein metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198506732

response to external stimulus
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
has_exact_synonym: response to environmental stimulus
has_obo_namespace: biological_process
id: GO:0009605
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:hb

endomembrane system organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
has_exact_synonym: endomembrane organization
has_exact_synonym: endomembrane system organisation
has_obo_namespace: biological_process
id: GO:0010256
in_subset: goslim drosophila

Axiom
annotated source: endomembrane system organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
database_cross_reference: GOC:mah
database_cross_reference: GOC:sm

Axiom
annotated source: endomembrane system organization
annotated property: has_exact_synonym
annotated target: endomembrane system organisation
database_cross_reference: GOC:mah

miRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
database_cross_reference: Reactome:R-HSA-203927
has_exact_synonym: microRNA metabolic process
has_obo_namespace: biological_process
id: GO:0010586
in_subset: goslim drosophila

Axiom
annotated source: miRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
database_cross_reference: PMID:17993620

MicroRNA (miRNA) biogenesis
type: Axiom
annotated source: miRNA metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203927

programmed cell death
type: Class
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24835
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Reactome:R-HSA-5357801
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

Programmed Cell Death
type: Axiom
annotated source: programmed cell death
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5357801

cell growth
type: Class
definition: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has_alternative_id: GO:0048591
has_exact_synonym: cellular growth
has_exact_synonym: growth of cell
has_obo_namespace: biological_process
has_related_synonym: cell expansion
has_related_synonym: metabolic process resulting in cell growth
has_related_synonym: metabolism resulting in cell growth
has_related_synonym: non-developmental cell growth
has_related_synonym: non-developmental growth of a unicellular organism
id: GO:0016049
in_subset: gocheck do not annotate
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell growth
annotated property: definition
annotated target: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
database_cross_reference: GOC:ai

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental cell growth
database_cross_reference: GOC:mah

Axiom
annotated source: cell growth
annotated property: has_related_synonym
annotated target: non-developmental growth of a unicellular organism
database_cross_reference: GOC:mah

mRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
database_cross_reference: Reactome:R-HSA-111367
has_exact_synonym: mRNA metabolism
has_obo_namespace: biological_process
id: GO:0016071
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: mRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
database_cross_reference: ISBN:0198506732

SLBP independent Processing of Histone Pre-mRNAs
type: Axiom
annotated source: mRNA metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-111367

rRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.
has_exact_synonym: rRNA metabolism
has_obo_namespace: biological_process
id: GO:0016072
in_subset: goslim drosophila

Axiom
annotated source: rRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes.
database_cross_reference: ISBN:0198506732

snRNA metabolic process
type: Class
definition: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
has_exact_synonym: snRNA metabolism
has_obo_namespace: biological_process
id: GO:0016073
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: snRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.
database_cross_reference: ISBN:0198506732

sno(s)RNA metabolic process
type: Class
definition: The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.
has_narrow_synonym: box C/D sRNA metabolic process
has_narrow_synonym: snoRNA metabolism
has_obo_namespace: biological_process
id: GO:0016074
in_subset: goslim drosophila
in_subset: goslim pombe

Axiom
annotated source: sno(s)RNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.
database_cross_reference: GOC:krc

vesicle-mediated transport
type: Class
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/25421
has_alternative_id: GO:0006899
has_exact_synonym: vesicle transport
has_exact_synonym: vesicular transport
has_narrow_synonym: nonselective vesicle transport
has_obo_namespace: biological_process
has_related_synonym: protein sorting along secretory pathway
has_related_synonym: vesicle trafficking
id: GO:0016192
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: vesicle-mediated transport
annotated property: definition
annotated target: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: ISBN:08789310662000

Axiom
annotated source: vesicle-mediated transport
annotated property: has_exact_synonym
annotated target: vesicular transport
database_cross_reference: GOC:mah

lipase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a lipid.
term tracker item: https://github.com/geneontology/go-ontology/issues/21843
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
database_cross_reference: Reactome:R-HSA-163402
database_cross_reference: Reactome:R-HSA-163432
has_obo_namespace: molecular_function
id: GO:0016298
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: lipase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a lipid.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

diacylglycerol + H2O -> 2-acylglycerol + fatty acid
type: Axiom
annotated source: lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163402

cholesterol ester + H2O -> cholesterol + fatty acid
type: Axiom
annotated source: lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163432

kinase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_exact_synonym: phosphokinase activity
has_obo_namespace: molecular_function
id: GO:0016301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.

Axiom
annotated source: kinase activity
annotated property: definition
annotated target: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: ISBN:0198506732

FN3KRP phosphorylates PsiAm, RibAm
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788855

FN3K phosphorylates ketosamines
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788867

oxidoreductase activity
type: Class
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-2161612
database_cross_reference: Reactome:R-HSA-265296
database_cross_reference: Reactome:R-HSA-266051
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
database_cross_reference: Reactome:R-HSA-9759549
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

PGH2 is reduced to PGF2a by FAM213B
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161612

Arachidonate is oxidised to 5S-HpETE by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-265296

5S-HpETE is dehydrated to LTA4 by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-266051

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759549

transferase activity
type: Class
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5333607
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

GSSeH combines with bGalNAc derivative to form GSSebGalNac
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333607

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

acyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/20486
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0008415
database_cross_reference: EC:2.3.-.-
database_cross_reference: Reactome:R-HSA-159431
database_cross_reference: Reactome:R-HSA-192312
database_cross_reference: Reactome:R-HSA-193491
database_cross_reference: Reactome:R-HSA-8858298
has_exact_synonym: transferase activity, transferring acyl groups
has_obo_namespace: molecular_function
id: GO:0016746
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: acyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.3.-.-

Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159431

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192312

Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-193491

HRASLS transfer acyl group from PC to PE to form NAPE
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8858298

glycosyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0016932
database_cross_reference: EC:2.4.-.-
database_cross_reference: Reactome:R-HSA-5173005
database_cross_reference: Reactome:R-HSA-6785565
has_exact_synonym: transferase activity, transferring glycosyl groups
has_exact_synonym: transglycosidase activity
has_exact_synonym: transglycosylase activity
has_narrow_synonym: transferase activity, transferring other glycosyl groups
has_obo_namespace: molecular_function
id: GO:0016757
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: glycosyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

B3GALTL transfers glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5173005

Defective B3GALTL does not transfer glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6785565

transferase activity, transferring alkyl or aryl (other than methyl) groups
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0016766
database_cross_reference: EC:2.5.1.-
database_cross_reference: Reactome:R-HSA-3095889
database_cross_reference: Reactome:R-HSA-4419978
database_cross_reference: Reactome:R-HSA-4755545
database_cross_reference: Reactome:R-HSA-6782893
has_exact_synonym: transferase activity, transferring alkyl or aryl groups, other than methyl groups
has_obo_namespace: molecular_function
id: GO:0016765
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: definition
annotated target: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.5.1.-

MMACHC dealkylates RCbl
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3095889

DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4419978

Defective DHDDS does not elongate E,E-FPP
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4755545

TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782893

phosphotransferase activity, alcohol group as acceptor
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.1.-
database_cross_reference: Reactome:R-HSA-2161193
database_cross_reference: Reactome:R-HSA-9941039
has_obo_namespace: molecular_function
id: GO:0016773
in_subset: goslim drosophila

Axiom
annotated source: phosphotransferase activity, alcohol group as acceptor
annotated property: definition
annotated target: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
database_cross_reference: EC:2.7.1.-

abacavir + AMP => abacavir monophosphate + adenosine
type: Axiom
annotated source: phosphotransferase activity, alcohol group as acceptor
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161193

FAM20B phosphorylates Xyl moiety
type: Axiom
annotated source: phosphotransferase activity, alcohol group as acceptor
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9941039

nucleotidyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.7.-
database_cross_reference: Reactome:R-HSA-6782434
has_obo_namespace: molecular_function
id: GO:0016779
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: nucleotidyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7.7.-

THG1L transfers GMP to 5' end of tRNA(His)
type: Axiom
annotated source: nucleotidyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782434

hydrolase activity
type: Class
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
database_cross_reference: Reactome:R-HSA-9942295
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9942295

phosphatase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/25755
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0003869
has_alternative_id: GO:0016302
database_cross_reference: EC:3.1.3.-
database_cross_reference: Reactome:R-HSA-4419986
database_cross_reference: Reactome:R-HSA-9636457
database_cross_reference: Reactome:R-HSA-9837419
database_cross_reference: Reactome:R-HSA-9940993
has_exact_synonym: phosphoric monoester hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: phosphatase
id: GO:0016791
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: phosphatase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pg

Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4419986

SapM dephosphorylates PI3P
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9636457

PANK4 hydrolyzes PPANT to pantetheine
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9837419

PXYLP1 dephosphorylates Xyl moiety
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9940993

hydrolase activity, acting on glycosyl bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any glycosyl bond.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.2.-.-
database_cross_reference: Reactome:R-HSA-1793176
database_cross_reference: Reactome:R-HSA-2065233
database_cross_reference: Reactome:R-HSA-5333609
has_exact_synonym: glycosidase activity
has_narrow_synonym: N-glycosylase
has_narrow_synonym: glycosylase
has_obo_namespace: molecular_function
id: GO:0016798
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any glycosyl bond.
database_cross_reference: GOC:jl

DS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1793176

CS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2065233

MeSebGalNac is hydrolysed to MeSeH and bGalNac
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333609

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.5.-.-
database_cross_reference: Reactome:R-HSA-6803753
has_narrow_synonym: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
has_obo_namespace: molecular_function
id: GO:0016810
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
database_cross_reference: EC:3.5.-.-

NAAA hydrolyses NAEs to FAs and ethanolamine
type: Axiom
annotated source: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6803753

lyase activity
type: Class
definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:4.-.-.-
database_cross_reference: Reactome:R-HSA-5696408
database_cross_reference: Reactome:R-HSA-6782895
has_obo_namespace: molecular_function
id: GO:0016829
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lyase activity
annotated property: definition
annotated target: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5696408

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782895

isomerase activity
type: Class
definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:5.-.-.-
database_cross_reference: Reactome:R-HSA-2161666
database_cross_reference: Reactome:R-HSA-2161735
database_cross_reference: Reactome:R-HSA-6787623
has_narrow_synonym: other isomerase activity
has_obo_namespace: molecular_function
id: GO:0016853
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: isomerase activity
annotated property: definition
annotated target: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: ISBN:0198506732

PGA2 is isomerised to PGC2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161666

PGC2 is isomerised to PGB2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161735

GFUS dimer epimerises GDP-DHDMan to GDP-KDGal
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787623

ligase activity
type: Class
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: EC:6.-.-.-

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

ubiquitin-like protein transferase activity
type: Class
subclass of: acyltransferase activity
definition: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/24697
has_alternative_id: GO:0008639
has_alternative_id: GO:0008640
has_broad_synonym: E2
database_cross_reference: Reactome:R-HSA-5678490
database_cross_reference: Reactome:R-HSA-688137
has_exact_synonym: small conjugating protein transferase activity
has_narrow_synonym: small conjugating protein ligase activity
has_narrow_synonym: small protein conjugating enzyme activity
has_narrow_synonym: ubiquitin-like conjugating enzyme activity
has_narrow_synonym: ubiquitin-like-protein ligase activity
has_obo_namespace: molecular_function
has_related_synonym: E3
id: GO:0019787
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:rn
database_cross_reference: PMID:10806345
database_cross_reference: PMID:10884686

ATG16L1 complex transfers LC3 from ATG3 to PE
type: Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5678490

RIP2 is K63 polyubiquitinated
type: Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-688137

Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: has_exact_synonym
annotated target: small conjugating protein transferase activity
database_cross_reference: GOC:dph

Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: has_narrow_synonym
annotated target: small conjugating protein ligase activity
database_cross_reference: GOC:dph

Axiom
annotated source: ubiquitin-like protein transferase activity
annotated property: has_related_synonym
annotated target: E3
database_cross_reference: GOC:dph

transmembrane transporter activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: transmembrane transport
definition: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
has_alternative_id: GO:0005386
has_alternative_id: GO:0015563
has_alternative_id: GO:0015646
has_alternative_id: GO:0022891
has_alternative_id: GO:0022892
database_cross_reference: Reactome:R-HSA-1236947
database_cross_reference: Reactome:R-HSA-2142859
database_cross_reference: Reactome:R-HSA-2161500
database_cross_reference: Reactome:R-HSA-429036
database_cross_reference: Reactome:R-HSA-434650
database_cross_reference: Reactome:R-HSA-549129
database_cross_reference: Reactome:R-HSA-549279
database_cross_reference: Reactome:R-HSA-549304
database_cross_reference: Reactome:R-HSA-549322
database_cross_reference: Reactome:R-HSA-561041
database_cross_reference: Reactome:R-HSA-561054
database_cross_reference: Reactome:R-HSA-561072
database_cross_reference: Reactome:R-HSA-5638209
database_cross_reference: Reactome:R-HSA-5671707
database_cross_reference: Reactome:R-HSA-6784434
database_cross_reference: Reactome:R-HSA-6784436
database_cross_reference: Reactome:R-HSA-8954513
database_cross_reference: Reactome:R-HSA-9794270
database_cross_reference: Reactome:R-HSA-9794523
database_cross_reference: Reactome:R-HSA-9794830
database_cross_reference: Reactome:R-HSA-9795207
has_obo_namespace: molecular_function
has_related_synonym: substrate-specific transmembrane transporter activity
has_related_synonym: substrate-specific transporter activity
has_related_synonym: uptake permease activity
has_related_synonym: uptake transmembrane transporter activity
id: GO:0022857
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

Egress of internalized antigen to the cytosol via sec61
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236947

Growing HA is extruded from the cell by ABCC5
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2142859

abacavir [extracellular] => abacavir [cytosol]
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161500

SLC2A9 transports Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-429036

MATEs mediate extrusion of xenobiotics
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-434650

OCT1 transports organic cations into hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549129

OCT2 mediates tubular uptake of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549279

OCT3 mediates renal clearance of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549304

OCT1 transports organic cations out of hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549322

OAT1,2,3 transport organic anions with antiport of dicarboxylic acids
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561041

OCT2 mediates tubular secretion of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561054

OCT3 mediates renal uptake of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561072

Defective SLC2A9 does not transport Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638209

Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5671707

An unknown carrier transports cytosolic glyoxylate to the peroxisome
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784434

An unknown carrier transports mitochondrial glyoxylate to the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784436

NAASP translocates from mitochondrial matrix to cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8954513

SLCO1A2 transports Cipro(1+) into the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794270

SLC22A1 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794523

SLC22A8 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794830

SLC22A1 transports Cipro into hepatic cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9795207

cell junction
type: Class
definition: A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
database_cross_reference: Wikipedia:Cell_junction
has_obo_namespace: cellular_component
id: GO:0030054
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim flybase ribbon

Axiom
annotated source: cell junction
annotated property: definition
annotated target: A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
database_cross_reference: GOC:aruk
database_cross_reference: GOC:bc
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:26820516
database_cross_reference: PMID:28096264

coated vesicle
type: Class
definition: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
has_alternative_id: GO:0005909
database_cross_reference: NIF_Subcellular:sao1985096626
has_obo_namespace: cellular_component
id: GO:0030135
in_subset: goslim drosophila

Axiom
annotated source: coated vesicle
annotated property: definition
annotated target: Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
database_cross_reference: ISBN:0815316194

cell differentiation
type: Class
definition: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
term tracker item: https://github.com/geneontology/go-ontology/issues/24390
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
id: GO:0030154
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

protein catabolic process
type: Class
definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
has_alternative_id: GO:0044254
has_alternative_id: GO:0044257
database_cross_reference: Wikipedia:Protein_catabolism
has_exact_synonym: cellular protein breakdown
has_exact_synonym: cellular protein catabolic process
has_exact_synonym: cellular protein catabolism
has_exact_synonym: cellular protein degradation
has_exact_synonym: protein breakdown
has_exact_synonym: protein catabolism
has_exact_synonym: protein degradation
has_narrow_synonym: multicellular organismal protein catabolic process
has_obo_namespace: biological_process
has_related_synonym: pheromone catabolic process
has_related_synonym: pheromone catabolism
id: GO:0030163
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.

Axiom
annotated source: protein catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
database_cross_reference: GOC:mah

extracellular matrix organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: Reactome:R-HSA-1474244
has_exact_synonym: extracellular matrix organisation
has_obo_namespace: biological_process
has_related_synonym: extracellular matrix organization and biogenesis
id: GO:0030198
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: extracellular matrix organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: GOC:mah

Extracellular matrix organization
type: Axiom
annotated source: extracellular matrix organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1474244

Axiom
annotated source: extracellular matrix organization
annotated property: has_related_synonym
annotated target: extracellular matrix organization and biogenesis
database_cross_reference: GOC:mah

enzyme regulator activity
type: Class
definition: A molecular function regulator that modulates a catalytic activity.
has_alternative_id: GO:0010576
has_exact_synonym: catalytic regulator activity
has_exact_synonym: enzyme modulator
has_narrow_synonym: metalloenzyme regulator activity
has_obo_namespace: molecular_function
id: GO:0030234
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.

Axiom
annotated source: enzyme regulator activity
annotated property: definition
annotated target: A molecular function regulator that modulates a catalytic activity.
database_cross_reference: GOC:pdt

Axiom
annotated source: enzyme regulator activity
annotated property: has_exact_synonym
annotated target: catalytic regulator activity
database_cross_reference: GOC:dph

carbohydrate binding
type: Class
definition: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
has_alternative_id: GO:0005529
has_exact_synonym: sugar binding
has_obo_namespace: molecular_function
has_related_synonym: selectin
id: GO:0030246
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: carbohydrate binding
annotated property: definition
annotated target: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
database_cross_reference: GOC:mah

external encapsulating structure
type: Class
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
term tracker item: https://github.com/geneontology/go-ontology/issues/31720
has_obo_namespace: cellular_component
id: GO:0030312
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.

Axiom
annotated source: external encapsulating structure
annotated property: definition
annotated target: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
database_cross_reference: GOC:curators

cytoskeleton-dependent intracellular transport
type: Class
definition: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
has_obo_namespace: biological_process
id: GO:0030705
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: cytoskeleton-dependent intracellular transport
annotated property: definition
annotated target: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
database_cross_reference: GOC:mah

extracellular matrix
type: Class
subclass of: external encapsulating structure
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
has_alternative_id: GO:0005578
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: Wikipedia:Extracellular_matrix
has_exact_synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: extracellular matrix
annotated property: definition
annotated target: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rph
database_cross_reference: PMID:21123617
database_cross_reference: PMID:28089324
database_cross_reference: PMID:33605520

regulatory ncRNA-mediated gene silencing
type: Class
definition: A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
term tracker item: https://github.com/geneontology/go-ontology/issues/22202
term tracker item: https://github.com/geneontology/go-ontology/issues/22635
database_cross_reference: Reactome:R-HSA-211000
has_exact_synonym: RNA-dependent gene silencing
has_obo_namespace: biological_process
has_related_synonym: RNA-mediated gene silencing
has_related_synonym: gene silencing by RNA
id: GO:0031047
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: regulatory ncRNA-mediated gene silencing
annotated property: definition
annotated target: A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
database_cross_reference: PMID:15020054

Gene Silencing by RNA
type: Axiom
annotated source: regulatory ncRNA-mediated gene silencing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-211000

protein tag activity
type: Class
definition: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
has_broad_synonym: covalent modifier
has_exact_synonym: protein tag
has_exact_synonym: ubiquitin-like protein modifier
has_obo_namespace: molecular_function
has_related_synonym: protein tagging activity
has_related_synonym: ubiquitin
id: GO:0031386
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures.

Axiom
annotated source: protein tag activity
annotated property: definition
annotated target: A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
database_cross_reference: GOC:dos
database_cross_reference: PMID:19028679
database_cross_reference: PMID:20054389
database_cross_reference: PMID:6305978

Axiom
annotated source: protein tag activity
annotated property: has_broad_synonym
annotated target: covalent modifier
database_cross_reference: GOC:vw

piRNA processing
type: Class
subclass of: RNA processing
subclass of: Restriction
  on property: part of
  some values from: regulatory ncRNA-mediated gene silencing
definition: A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
term tracker item: https://github.com/geneontology/go-ontology/issues/23135
has_alternative_id: GO:1990511
database_cross_reference: Reactome:R-HSA-5601884
has_exact_synonym: PIWI-associated RNA biogenesis
has_exact_synonym: PIWI-associated RNA processing
has_exact_synonym: piRNA biogenesis
has_obo_namespace: biological_process
has_related_synonym: Piwi-associated RNA biosynthetic process
has_related_synonym: Piwi-associated RNA metabolic process
has_related_synonym: piRNA biosynthetic process
has_related_synonym: piRNA metabolic process
has_related_synonym: piRNA metabolism
id: GO:0034587
in_subset: goslim drosophila

Axiom
annotated source: piRNA processing
annotated property: definition
annotated target: A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
database_cross_reference: GOC:kmv
database_cross_reference: PMID:23329111
database_cross_reference: PMID:24696457
database_cross_reference: PMID:34724117

PIWI-interacting RNA (piRNA) biogenesis
type: Axiom
annotated source: piRNA processing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5601884

intracellular signal transduction
type: Class
definition: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
created by: bf
creation date: 2010-05-14T01:14:37Z
has_alternative_id: GO:0007242
has_alternative_id: GO:0007243
has_alternative_id: GO:0023013
has_alternative_id: GO:0023034
has_narrow_synonym: intracellular signal transduction pathway
has_narrow_synonym: signal transmission via intracellular cascade
has_obo_namespace: biological_process
has_related_synonym: intracellular signaling cascade
has_related_synonym: intracellular signaling pathway
id: GO:0035556
in_subset: goslim drosophila

Axiom
annotated source: intracellular signal transduction
annotated property: definition
annotated target: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:3527303782

Axiom
annotated source: intracellular signal transduction
annotated property: has_related_synonym
annotated target: intracellular signaling cascade
database_cross_reference: GOC:signaling

signaling receptor activity
type: Class
definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
created by: bf
creation date: 2011-08-01T02:45:27Z
has_alternative_id: GO:0004872
has_alternative_id: GO:0019041
has_broad_synonym: receptor activity
has_exact_synonym: receptor activity involved in signal transduction
has_exact_synonym: signalling receptor activity
has_obo_namespace: molecular_function
id: GO:0038023
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: signaling receptor activity
annotated property: definition
annotated target: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
database_cross_reference: GOC:bf
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity involved in signal transduction
database_cross_reference: GOC:bf

cargo receptor activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
subclass of: Restriction
  on property: has part
  some values from: molecular adaptor activity
definition: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
term tracker item: https://github.com/geneontology/go-ontology/issues/26872
term tracker item: https://github.com/geneontology/go-ontology/issues/30576
created by: bf
creation date: 2011-08-01T02:50:45Z
has_broad_synonym: receptor activity
has_broad_synonym: transport receptor activity
database_cross_reference: Reactome:R-HSA-203716
database_cross_reference: Reactome:R-HSA-2160915
database_cross_reference: Reactome:R-HSA-2248891
database_cross_reference: Reactome:R-HSA-3000103
database_cross_reference: Reactome:R-HSA-3000112
database_cross_reference: Reactome:R-HSA-3000122
database_cross_reference: Reactome:R-HSA-3000137
database_cross_reference: Reactome:R-HSA-350168
database_cross_reference: Reactome:R-HSA-350186
database_cross_reference: Reactome:R-HSA-9662747
database_cross_reference: Reactome:R-HSA-9662818
database_cross_reference: Reactome:R-HSA-9759202
database_cross_reference: Reactome:R-HSA-9759209
has_narrow_synonym: endocytic receptor activity
has_narrow_synonym: receptor activity involved in receptor-mediated endocytosis
has_obo_namespace: molecular_function
id: GO:0038024
in_subset: goslim drosophila
in_subset: goslim generic
comment: Notes: (1) For receptors binding a molecule but coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857'.

Axiom
annotated source: cargo receptor activity
annotated property: definition
annotated target: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.
database_cross_reference: PMID:15239958
database_cross_reference: PMID:27903609

Axiom
annotated source: cargo receptor activity
annotated property: has_broad_synonym
annotated target: transport receptor activity
database_cross_reference: GOC:signaling

eNOS:Caveolin-1 complex binds to Nostrin
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203716

Receptor-mediated uptake of HA
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2160915

M6PR transports activated ARSA to the lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2248891

CUBN:AMN binds CBLIF:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000103

CD320-mediated TCN2:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000112

CD320 binds extracellular TCN2:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000122

CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000137

LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350168

CUBN binds GC:25(OH)D
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350186

iRHOM2 transports ADAM17 from ER to the Golgi-network
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9662747

iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9662818

LRP2-mediated TCN2:RCbl uptake and delivery to lysosome
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759202

LRP2 binds extracellular TCN2:RCbl
type: Axiom
annotated source: cargo receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759209

Axiom
annotated source: cargo receptor activity
annotated property: has_narrow_synonym
annotated target: endocytic receptor activity
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:0123645387
database_cross_reference: PMID:12671190

Axiom
annotated source: cargo receptor activity
annotated property: has_narrow_synonym
annotated target: receptor activity involved in receptor-mediated endocytosis
database_cross_reference: GOC:bf

response to chemical
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
has_exact_synonym: response to chemical stimulus
has_exact_synonym: response to chemical substance
has_obo_namespace: biological_process
id: GO:0042221
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to chemical
annotated property: has_exact_synonym
annotated target: response to chemical stimulus
database_cross_reference: GOC:dos

ribosome biogenesis
type: Class
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
has_alternative_id: GO:0007046
has_exact_synonym: ribosome biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042254
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: ribosome biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:ma
database_cross_reference: PMID:26404467
database_cross_reference: Wikipedia:Ribosome_biogenesis

structural constituent of cuticle
type: Class
definition: The action of a molecule that contributes to the structural integrity of a cuticle.
has_obo_namespace: molecular_function
id: GO:0042302
in_subset: goslim drosophila

Axiom
annotated source: structural constituent of cuticle
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a cuticle.
database_cross_reference: GOC:jl

molting cycle
type: Class
definition: The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.
has_obo_namespace: biological_process
id: GO:0042303
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: molting cycle
annotated property: definition
annotated target: The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

cuticle development
type: Class
definition: The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
has_exact_synonym: cuticle anabolism
has_exact_synonym: cuticle biosynthesis
has_exact_synonym: cuticle biosynthetic process
has_exact_synonym: cuticle formation
has_exact_synonym: cuticle synthesis
has_obo_namespace: biological_process
id: GO:0042335
in_subset: goslim drosophila

Axiom
annotated source: cuticle development
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
database_cross_reference: ISBN:0192800825

histone binding
type: Class
definition: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/23106
has_obo_namespace: molecular_function
has_related_synonym: histone-specific chaperone activity
id: GO:0042393
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: histone binding
annotated property: definition
annotated target: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16209651
database_cross_reference: PMID:30212449
database_cross_reference: PMID:9305837

pigment metabolic process
type: Class
definition: The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
has_exact_synonym: pigment metabolism
has_obo_namespace: biological_process
id: GO:0042440
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: pigment metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

protein folding chaperone
type: Class
subclass of: Restriction
  on property: part of
  some values from: protein folding
definition: Binding to a protein or a protein-containing complex to assist the protein folding process.
term tracker item: https://github.com/geneontology/go-ontology/issues/30552
created by: jl
creation date: 2009-09-25T11:33:48Z
has_broad_synonym: chaperone activity
database_cross_reference: Reactome:R-HSA-9018785
database_cross_reference: Reactome:R-HSA-9683772
database_cross_reference: Reactome:R-HSA-9694337
database_cross_reference: Reactome:R-HSA-9855212
database_cross_reference: Reactome:R-HSA-9865893
database_cross_reference: Reactome:R-HSA-9866253
has_exact_synonym: protein binding involved in protein folding
has_obo_namespace: molecular_function
id: GO:0044183
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
comment: Note that a protein folding chaperone binds an unfolded protein to fold it. Do not confuse with unfolded protein holdase activity, which binds an unfolded protein and keeps it unfolded to deliver it to its final destination.

Axiom
annotated source: protein folding chaperone
annotated property: definition
annotated target: Binding to a protein or a protein-containing complex to assist the protein folding process.
database_cross_reference: GOC:mtg_cambridge_2009

RHOBTB2 binds GTP
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018785

Trimmed spike protein binds to calnexin
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9683772

Trimmed spike protein binds to calnexin
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9694337

SDHA binds to SDHB
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9855212

MT-CYB is translated
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9865893

apo-UQCRFS1 binds LYRM7
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9866253

multi-organism reproductive process
type: Class
definition: A biological process that directly contributes to the process of producing new individuals, involving another organism.
created by: jl
creation date: 2012-09-19T15:56:30Z
has_obo_namespace: biological_process
id: GO:0044703
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: multi-organism reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals, involving another organism.
database_cross_reference: GOC:jl

cilium organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
created by: jl
creation date: 2013-03-27T15:09:58Z
has_exact_synonym: microtubule-based flagellum organization
has_obo_namespace: biological_process
id: GO:0044782
in_subset: goslim drosophila
in_subset: goslim generic
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.

Axiom
annotated source: cilium organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:jl

translation regulator activity
type: Class
definition: Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/29089
has_obo_namespace: molecular_function
id: GO:0045182
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation regulator activity
annotated property: definition
annotated target: Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
database_cross_reference: GOC:ai

synapse
type: Class
subclass of: cell junction
definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: NIF_Subcellular:sao914572699
database_cross_reference: Wikipedia:Chemical_synapse
has_exact_synonym: synaptic junction
has_narrow_synonym: mixed synapse
has_obo_namespace: cellular_component
has_related_synonym: electrotonic synapse
id: GO:0045202
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim synapse

Axiom
annotated source: synapse
annotated property: definition
annotated target: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
database_cross_reference: GOC:aruk
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:24619342
database_cross_reference: PMID:29383328
database_cross_reference: PMID:31998110

Axiom
annotated source: synapse
annotated property: has_narrow_synonym
annotated target: mixed synapse
database_cross_reference: NIF_Subcellular:sao1506103497

Axiom
annotated source: synapse
annotated property: has_related_synonym
annotated target: electrotonic synapse
database_cross_reference: NIF_Subcellular:sao1311109124

cell redox homeostasis
type: Class
definition: Any process that maintains the redox environment of a cell or compartment within a cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24135
term tracker item: https://github.com/geneontology/go-ontology/issues/30181
has_alternative_id: GO:0030503
has_alternative_id: GO:0045867
has_alternative_id: GO:0045868
has_broad_synonym: regulation of redox homeostasis
database_cross_reference: Reactome:R-HSA-1222541
database_cross_reference: Reactome:R-HSA-1222556
database_cross_reference: Wikipedia:Redox
has_obo_namespace: biological_process
has_related_synonym: regulation of cell redox homeostasis
id: GO:0045454
in_subset: goslim drosophila
in_subset: goslim metagenomics

Axiom
annotated source: cell redox homeostasis
annotated property: definition
annotated target: Any process that maintains the redox environment of a cell or compartment within a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
database_cross_reference: PMID:38689066

Cell redox homeostasis
type: Axiom
annotated source: cell redox homeostasis
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1222541

ROS and RNS production in phagocytes
type: Axiom
annotated source: cell redox homeostasis
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1222556

metal ion binding
type: Class
definition: Binding to a metal ion.
has_exact_synonym: metal binding
has_narrow_synonym: heavy metal binding
has_obo_namespace: molecular_function
id: GO:0046872
in_subset: goslim agr
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics

Axiom
annotated source: metal ion binding
annotated property: definition
annotated target: Binding to a metal ion.
database_cross_reference: GOC:ai

receptor ligand activity
type: Class
subclass of: Restriction
  on property: regulates
  some values from: signaling receptor activity
subclass of: Restriction
  on property: positively regulates
  some values from: signaling receptor activity
definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
term tracker item: https://github.com/geneontology/go-ontology/issues/14220
term tracker item: https://github.com/geneontology/go-ontology/issues/27076
term tracker item: https://github.com/geneontology/go-ontology/issues/31015
created by: mah
creation date: 2010-09-13T04:51:59Z
has_alternative_id: GO:0071884
has_broad_synonym: agonist
has_broad_synonym: signaling molecule
database_cross_reference: Reactome:R-HSA-381612
database_cross_reference: Reactome:R-HSA-8848663
has_exact_synonym: signaling receptor ligand activity
has_obo_namespace: molecular_function
has_related_synonym: receptor agonist activity
id: GO:0048018
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: receptor ligand activity
annotated property: definition
annotated target: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
database_cross_reference: GOC:kv
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

GLP1R binds GLP1
type: Axiom
annotated source: receptor ligand activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381612

ADIPOQ trimer binds ADIPOR dimers
type: Axiom
annotated source: receptor ligand activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848663

Axiom
annotated source: receptor ligand activity
annotated property: has_related_synonym
annotated target: receptor agonist activity
database_cross_reference: GOC:molecular_function_refactoring

multicellular organismal reproductive process
type: Class
definition: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
has_broad_synonym: organismal reproductive process
database_cross_reference: Reactome:R-HSA-1474165
has_exact_synonym: reproductive process in a multicellular organism
has_obo_namespace: biological_process
id: GO:0048609
in_subset: gocheck do not annotate
in_subset: goslim drosophila

Axiom
annotated source: multicellular organismal reproductive process
annotated property: definition
annotated target: The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

Reproduction
type: Axiom
annotated source: multicellular organismal reproductive process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1474165

cell motility
type: Class
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
has_exact_synonym: cell locomotion
has_exact_synonym: movement of a cell
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0048870
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell motility
annotated property: definition
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg

chemical homeostasis
type: Class
definition: Any biological process involved in the maintenance of an internal steady state of a chemical.
has_obo_namespace: biological_process
id: GO:0048878
in_subset: goslim drosophila

Axiom
annotated source: chemical homeostasis
annotated property: definition
annotated target: Any biological process involved in the maintenance of an internal steady state of a chemical.
database_cross_reference: GOC:isa_complete

synapse organization
type: Class
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
has_exact_synonym: synapse organisation
has_obo_namespace: biological_process
has_related_synonym: synapse development
has_related_synonym: synapse morphogenesis
has_related_synonym: synapse organization and biogenesis
id: GO:0050808
in_subset: goslim drosophila
in_subset: goslim synapse

Axiom
annotated source: synapse organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
database_cross_reference: GOC:ai
database_cross_reference: GOC:pr

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse development
database_cross_reference: GOC:aruk

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse morphogenesis
database_cross_reference: GOC:BHF

Axiom
annotated source: synapse organization
annotated property: has_related_synonym
annotated target: synapse organization and biogenesis
database_cross_reference: GOC:mah

cognition
type: Class
definition: The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
database_cross_reference: Wikipedia:Cognition
has_obo_namespace: biological_process
id: GO:0050890
in_subset: goslim drosophila

Axiom
annotated source: cognition
annotated property: definition
annotated target: The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
database_cross_reference: ISBN:0721619908

chromosome organization
type: Class
definition: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/22811
term tracker item: https://github.com/geneontology/go-ontology/issues/4585
has_alternative_id: GO:0006323
has_alternative_id: GO:0007001
has_alternative_id: GO:0051277
has_exact_synonym: DNA condensation
has_exact_synonym: chromosome organisation
has_narrow_synonym: DNA packaging
has_obo_namespace: biological_process
has_related_synonym: chromosome organization and biogenesis
has_related_synonym: maintenance of genome integrity
has_related_synonym: nuclear genome maintenance
id: GO:0051276
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: chromosome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: chromosome organization
annotated property: has_related_synonym
annotated target: chromosome organization and biogenesis
database_cross_reference: GOC:mah

cell division
type: Class
definition: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
database_cross_reference: Wikipedia:Cell_division
has_obo_namespace: biological_process
id: GO:0051301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.

Axiom
annotated source: cell division
annotated property: definition
annotated target: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
database_cross_reference: GOC:curators
database_cross_reference: GOC:di
database_cross_reference: GOC:pr

meiotic cell cycle
type: Class
definition: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
term tracker item: https://github.com/geneontology/go-ontology/issues/24599
has_alternative_id: GO:0007126
database_cross_reference: Wikipedia:Meiosis
has_obo_namespace: biological_process
has_related_synonym: meiosis
id: GO:0051321
in_subset: goslim drosophila
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: meiotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
database_cross_reference: GOC:ai

protein maturation
type: Class
definition: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: Reactome:R-HSA-9918432
has_obo_namespace: biological_process
id: GO:0051604
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein maturation
annotated property: definition
annotated target: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:ai

Maturation of DENV proteins
type: Axiom
annotated source: protein maturation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918432

carboxylic ester hydrolase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a carboxylic ester bond.
term tracker item: https://github.com/geneontology/go-ontology/issues/24654
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0004091
has_alternative_id: GO:0004302
has_alternative_id: GO:0004759
has_alternative_id: GO:0016789
database_cross_reference: EC:3.1.1.-
database_cross_reference: KEGG_REACTION:R00630
database_cross_reference: Reactome:R-HSA-5693691
database_cross_reference: Reactome:R-HSA-8937442
database_cross_reference: Reactome:R-HSA-9749792
database_cross_reference: UM-BBD_reactionID:r1025
has_obo_namespace: molecular_function
has_related_synonym: carboxylate esterase activity
has_related_synonym: carboxylic esterase activity
has_related_synonym: hydrolase activity acting on ester bonds
id: GO:0052689
in_subset: goslim drosophila

Axiom
annotated source: carboxylic ester hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a carboxylic ester bond.
database_cross_reference: EC:3.1.1.-
database_cross_reference: GOC:curators

CES1 trimer.CES2 hydrolyse COCN to BEG
type: Axiom
annotated source: carboxylic ester hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5693691

CES3 hydrolyses CHEST to CHOL and LCFA(-)
type: Axiom
annotated source: carboxylic ester hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8937442

CES1,CES2 hydrolyze ASA- to ST
type: Axiom
annotated source: carboxylic ester hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9749792

Axiom
annotated source: carboxylic ester hydrolase activity
annotated property: has_related_synonym
annotated target: hydrolase activity acting on ester bonds
database_cross_reference: EC:3.1.1.-

transmembrane transport
type: Class
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
created by: tb
creation date: 2015-10-21T13:22:47Z
has_alternative_id: GO:0090662
database_cross_reference: Reactome:R-HSA-382556
database_cross_reference: Reactome:R-HSA-425407
database_cross_reference: Reactome:R-HSA-5223345
has_exact_synonym: membrane transport
has_narrow_synonym: ATP hydrolysis coupled transmembrane transport
has_obo_namespace: biological_process
id: GO:0055085
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: transmembrane transport
annotated property: definition
annotated target: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

ABC-family protein mediated transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382556

SLC-mediated transmembrane transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-425407

Miscellaneous transport and binding events
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5223345

nucleobase-containing small molecule metabolic process
type: Class
definition: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: Reactome:R-HSA-15869
database_cross_reference: Reactome:R-HSA-2393930
has_exact_synonym: nucleobase, nucleoside and nucleotide metabolism
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
id: GO:0055086
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: definition
annotated target: The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
database_cross_reference: GOC:vw

Metabolism of nucleotides
type: Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-15869

Phosphate bond hydrolysis by NUDT proteins
type: Axiom
annotated source: nucleobase-containing small molecule metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2393930

molecular adaptor activity
type: Class
definition: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
term tracker item: https://github.com/geneontology/go-ontology/issues/31509
has_alternative_id: GO:0032947
database_cross_reference: Reactome:R-HSA-2564826
has_exact_synonym: binding, bridging
has_obo_namespace: molecular_function
id: GO:0060090
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular adaptor activity
annotated property: definition
annotated target: The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
database_cross_reference: GOC:mtg_MIT_16mar07
database_cross_reference: GOC:vw

4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold
type: Axiom
annotated source: molecular adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2564826

epithelium development
type: Class
definition: The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
has_obo_namespace: biological_process
id: GO:0060429
in_subset: goslim drosophila

Axiom
annotated source: epithelium development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mtg_lung

respiratory system development
type: Class
definition: The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
created by: dph
creation date: 2009-04-10T08:55:42Z
has_obo_namespace: biological_process
id: GO:0060541
in_subset: goslim drosophila

Axiom
annotated source: respiratory system development
annotated property: definition
annotated target: The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
database_cross_reference: GOC:dph

membrane organization
type: Class
definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
created by: jl
creation date: 2010-02-08T02:43:11Z
has_alternative_id: GO:0016044
has_alternative_id: GO:0044802
database_cross_reference: Reactome:R-HSA-199991
has_exact_synonym: cellular membrane organisation
has_exact_synonym: cellular membrane organization
has_exact_synonym: membrane organisation
has_obo_namespace: biological_process
has_related_synonym: membrane organization and biogenesis
has_related_synonym: single-organism membrane organization
id: GO:0061024
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: membrane organization
annotated property: definition
annotated target: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Membrane Trafficking
type: Axiom
annotated source: membrane organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-199991

Axiom
annotated source: membrane organization
annotated property: has_exact_synonym
annotated target: membrane organisation
database_cross_reference: GOC:mah

Axiom
annotated source: membrane organization
annotated property: has_related_synonym
annotated target: membrane organization and biogenesis
database_cross_reference: GOC:mah

muscle structure development
type: Class
definition: The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
created by: dph
creation date: 2010-03-09T08:55:14Z
has_obo_namespace: biological_process
id: GO:0061061
in_subset: goslim drosophila

Axiom
annotated source: muscle structure development
annotated property: definition
annotated target: The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
database_cross_reference: GOC:dph

protein-containing complex assembly
type: Class
definition: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/22580
has_alternative_id: GO:0006461
has_alternative_id: GO:0034622
has_alternative_id: GO:0043623
has_exact_synonym: cellular protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecule complex assembly
has_related_synonym: cellular protein-containing complex assembly
has_related_synonym: chaperone activity
has_related_synonym: macromolecular complex assembly
has_related_synonym: macromolecule complex assembly
has_related_synonym: protein complex assembly
has_related_synonym: protein complex formation
id: GO:0065003
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: protein-containing complex assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
database_cross_reference: GOC:jl

protein modification by small protein conjugation or removal
type: Class
definition: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
created by: mah
creation date: 2009-05-11T02:54:03Z
has_obo_namespace: biological_process
id: GO:0070647
in_subset: goslim drosophila
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: protein modification by small protein conjugation or removal
annotated property: definition
annotated target: A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
database_cross_reference: GOC:mah

circulatory system development
type: Class
definition: The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
created by: mah
creation date: 2010-11-16T11:27:39Z
has_alternative_id: GO:0072358
has_narrow_synonym: cardiovascular system development
has_obo_namespace: biological_process
id: GO:0072359
in_subset: goslim drosophila

Axiom
annotated source: circulatory system development
annotated property: definition
annotated target: The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
database_cross_reference: GOC:mah
database_cross_reference: UBERON:0001009

secretory vesicle
type: Class
definition: A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
has_obo_namespace: cellular_component
id: GO:0099503
in_subset: goslim drosophila

Axiom
annotated source: secretory vesicle
annotated property: definition
annotated target: A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
database_cross_reference: GOC:dos

synaptic signaling
type: Class
subclass of: Restriction
  on property: occurs in
  some values from: synapse
definition: Cell-cell signaling to, from or within a synapse.
has_obo_namespace: biological_process
id: GO:0099536
in_subset: goslim drosophila
in_subset: goslim synapse

Axiom
annotated source: synaptic signaling
annotated property: definition
annotated target: Cell-cell signaling to, from or within a synapse.
database_cross_reference: GOC:dos

general transcription initiation factor activity
type: Class
subclass of: Restriction
  on property: part of
  some values from: DNA-templated transcription
definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
created by: pg
creation date: 2018-05-24T07:51:23Z
has_exact_synonym: GTF activity
has_exact_synonym: basal transcription factor activity
has_exact_synonym: general transcription factor activity
has_obo_namespace: molecular_function
id: GO:0140223
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon
comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.

Axiom
annotated source: general transcription initiation factor activity
annotated property: definition
annotated target: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
database_cross_reference: GOC:txnOH-2018

molecular sensor activity
type: Class
definition: Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/28772
created by: pg
creation date: 2018-12-10T14:30:28Z
database_cross_reference: Reactome:R-HSA-9854368
has_exact_synonym: small molecular sensor activity
has_exact_synonym: small molecule sensing activity
has_narrow_synonym: small molecule sensor activity
has_obo_namespace: molecular_function
id: GO:0140299
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular sensor activity
annotated property: definition
annotated target: Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
database_cross_reference: PMID:26328879

ROS,RNS oxidize ACO2:4Fe-4S
type: Axiom
annotated source: molecular sensor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9854368

molecular sequestering activity
type: Class
definition: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
created by: pg
creation date: 2019-03-28T10:00:25Z
database_cross_reference: Reactome:R-HSA-203553
database_cross_reference: Reactome:R-HSA-203680
database_cross_reference: Reactome:R-HSA-2404134
database_cross_reference: Reactome:R-HSA-3245898
has_obo_namespace: molecular_function
id: GO:0140313
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: molecular sequestering activity
annotated property: definition
annotated target: Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
database_cross_reference: PMID:13130076

eNOS binds NOSIP
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203553

eNOS:NOSIP translocation from caveolae to intracellular compartments
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203680

RBP4:atROL binds TTR
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2404134

TCN1 binds correnoids in the circulation
type: Axiom
annotated source: molecular sequestering activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3245898

ATP-dependent activity
type: Class
subclass of: Restriction
  on property: has part
  some values from: hydrolase activity
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324