GO_0000009
has db xref: Reactome:R-HSA-449718

Addition of a third mannose to the N-glycan precursor by ALG2
type: Axiom
annotated source: GO_0000009
annotated property: hasDbXref
annotated target: Reactome:R-HSA-449718

GO_0000016
has db xref: Reactome:R-HSA-189062
has db xref: Reactome:R-HSA-5658001

lactose + H2O => D-glucose + D-galactose
type: Axiom
annotated source: GO_0000016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189062

Defective LCT does not hydrolyze Lac
type: Axiom
annotated source: GO_0000016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5658001

GO_0000026
has db xref: Reactome:R-HSA-446187
has db xref: Reactome:R-HSA-446215
has db xref: Reactome:R-HSA-446216
has db xref: Reactome:R-HSA-4551297
has db xref: Reactome:R-HSA-4720478
has db xref: Reactome:R-HSA-9035514

ALG11 transfers the fourth and fifth Man to the N-glycan precursor
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446187

ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446215

ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446216

Defective ALG11 does not transfer Man to the N-glycan precursor
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4551297

Defective ALG9 does not add the seventh mannose to the N-glycan precursor
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4720478

Defective ALG9 does not add the last mannose to the N-glycan precursor
type: Axiom
annotated source: GO_0000026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035514

GO_0000030
has db xref: Reactome:R-HSA-162797
has db xref: Reactome:R-HSA-162830
has db xref: Reactome:R-HSA-446198
has db xref: Reactome:R-HSA-4720497

mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI
type: Axiom
annotated source: GO_0000030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162797

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate
type: Axiom
annotated source: GO_0000030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162830

ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
type: Axiom
annotated source: GO_0000030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446198

Defective ALG12 does not add mannose to the N-glycan precursor
type: Axiom
annotated source: GO_0000030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4720497

GO_0000033
has db xref: Reactome:R-HSA-446188
has db xref: Reactome:R-HSA-446208
has db xref: Reactome:R-HSA-4549368
has db xref: Reactome:R-HSA-4720473

ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
type: Axiom
annotated source: GO_0000033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446188

Addition of a second mannose to the N-glycan precursor by ALG2
type: Axiom
annotated source: GO_0000033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446208

Defective ALG2 does not transfer a second Man to N-glycan precursor
type: Axiom
annotated source: GO_0000033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4549368

Defective ALG3 does not add mannose to the N-glycan precursor
type: Axiom
annotated source: GO_0000033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4720473

GO_0000048
has db xref: Reactome:R-HSA-156912

Peptide transfer from P-site tRNA to the A-site tRNA
type: Axiom
annotated source: GO_0000048
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156912

GO_0000064
has db xref: Reactome:R-HSA-70634

ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
type: Axiom
annotated source: GO_0000064
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70634

GO_0000095
has db xref: Reactome:R-HSA-8855062

SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy
type: Axiom
annotated source: GO_0000095
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855062

GO_0000140
has db xref: Reactome:R-HSA-75883

DHRS7B reduces GO3P to HXDG3P
type: Axiom
annotated source: GO_0000140
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75883

GO_0000146
has db xref: Reactome:R-HSA-2316352
has db xref: Reactome:R-HSA-432237
has db xref: Reactome:R-HSA-9023171

SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
type: Axiom
annotated source: GO_0000146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2316352

Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane
type: Axiom
annotated source: GO_0000146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432237

Insulin secretory granule translocates across the cortical actin network
type: Axiom
annotated source: GO_0000146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023171

GO_0000149
has db xref: Reactome:R-HSA-210426
has db xref: Reactome:R-HSA-210430
has db xref: Reactome:R-HSA-265166
has db xref: Reactome:R-HSA-372505
has db xref: Reactome:R-HSA-372529
has db xref: Reactome:R-HSA-374899
has db xref: Reactome:R-HSA-374922
has db xref: Reactome:R-HSA-376357
has db xref: Reactome:R-HSA-376364
has db xref: Reactome:R-HSA-376369
has db xref: Reactome:R-HSA-380574
has db xref: Reactome:R-HSA-380869
has db xref: Reactome:R-HSA-380901
has db xref: Reactome:R-HSA-380905
has db xref: Reactome:R-HSA-888589
has db xref: Reactome:R-HSA-9023173
has db xref: Reactome:R-HSA-917744

Glutamate synaptic vesicle docking and priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210426

Release of L-Glutamate at the synapse
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210430

Exocytosis of Insulin
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265166

Acetylcholine synaptic vesicle docking and priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372505

Release of acetylcholine at the synapse
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372529

Release of noradrenaline at the synapse
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374899

Noradrenalin synaptic vesicle docking and priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374922

Vamp7 associated Lysosome to Plasma membrane transport
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-376357

Vamp8 associated secretory vesicle to plasma membrane transport
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-376364

Vamp2 associated secretory vesicle to plasma membrane transport
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-376369

Dopamine synaptic vesicle docking and priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380574

Release of docked dopamine loaded synaptic vesicle
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380869

Release of docked serotonin loaded synaptic vesicle
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380901

Serotonin loaded synaptic vesicle docking and priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380905

Release of GABA at the synapse
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-888589

Insulin secretory granule docks at the plasma membrane
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023173

GABA loaded synaptic vesicle Docking and Priming
type: Axiom
annotated source: GO_0000149
annotated property: hasDbXref
annotated target: Reactome:R-HSA-917744

GO_0000150
has db xref: Reactome:R-HSA-912458

Formation of meiotic heteroduplex
type: Axiom
annotated source: GO_0000150
annotated property: hasDbXref
annotated target: Reactome:R-HSA-912458

GO_0000170
has db xref: Reactome:R-HSA-428260

DEGS2 oxygenates dihydroceramide
type: Axiom
annotated source: GO_0000170
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428260

GO_0000175
has db xref: Reactome:R-HSA-430028
has db xref: Reactome:R-HSA-6791222
has db xref: Reactome:R-HSA-6791227
has db xref: Reactome:R-HSA-9682603
has db xref: Reactome:R-HSA-9694632
has db xref: Reactome:R-HSA-9822437
has db xref: Reactome:R-HSA-9836585
has db xref: Reactome:R-HSA-9836822

Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-430028

21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6791222

47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6791227

nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9682603

nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694632

DIS3L2 hydrolyzes uridylated mRNA
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9822437

SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836585

REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides
type: Axiom
annotated source: GO_0000175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836822

GO_0000179
has db xref: Reactome:R-HSA-6790994
has db xref: Reactome:R-HSA-6793066

DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851
type: Axiom
annotated source: GO_0000179
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6790994

TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937
type: Axiom
annotated source: GO_0000179
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6793066

GO_0000224
has db xref: Reactome:R-HSA-8850594

Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
type: Axiom
annotated source: GO_0000224
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8850594

GO_0000225
has db xref: Reactome:R-HSA-162857

N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate
type: Axiom
annotated source: GO_0000225
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162857

GO_0000248
has db xref: Reactome:R-HSA-195664
has db xref: Reactome:R-HSA-6807053

Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol
type: Axiom
annotated source: GO_0000248
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195664

SC5D desaturates LTHSOL to 7-dehydroCHOL
type: Axiom
annotated source: GO_0000248
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807053

GO_0000250
has db xref: Reactome:R-HSA-191366

Squalene 2,3-epoxide cyclizes, forming lanosterol
type: Axiom
annotated source: GO_0000250
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191366

GO_0000252
has db xref: Reactome:R-HSA-194642
has db xref: Reactome:R-HSA-194718

4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one
type: Axiom
annotated source: GO_0000252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194642

4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)
type: Axiom
annotated source: GO_0000252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194718

GO_0000253
has db xref: Reactome:R-HSA-194632
has db xref: Reactome:R-HSA-194689

Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)
type: Axiom
annotated source: GO_0000253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194632

4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol
type: Axiom
annotated source: GO_0000253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194689

GO_0000254
has db xref: Reactome:R-HSA-194641
has db xref: Reactome:R-HSA-194669

4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol
type: Axiom
annotated source: GO_0000254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194641

4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol
type: Axiom
annotated source: GO_0000254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194669

GO_0000285
has db xref: Reactome:R-HSA-1675910
has db xref: Reactome:R-HSA-1675921
has db xref: Reactome:R-HSA-1676134
has db xref: Reactome:R-HSA-1676168

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
type: Axiom
annotated source: GO_0000285
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675910

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
type: Axiom
annotated source: GO_0000285
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675921

PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
type: Axiom
annotated source: GO_0000285
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676134

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
type: Axiom
annotated source: GO_0000285
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676168

GO_0000295
has db xref: Reactome:R-HSA-389652

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
type: Axiom
annotated source: GO_0000295
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389652

GO_0000309
has db xref: Reactome:R-HSA-8939959

NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+
type: Axiom
annotated source: GO_0000309
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8939959

GO_0000334
has db xref: Reactome:R-HSA-71218

3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde
type: Axiom
annotated source: GO_0000334
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71218

GO_0000386
has db xref: Reactome:R-HSA-9770236

Formation of the Spliceosomal P complex and exon ligation
type: Axiom
annotated source: GO_0000386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770236

GO_0000703
has db xref: Reactome:R-HSA-110224
has db xref: Reactome:R-HSA-110226
has db xref: Reactome:R-HSA-110227

Cleavage of thymine glycol by NTHL1 glycosylase
type: Axiom
annotated source: GO_0000703
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110224

Cleavage of cytosine glycol by NTHL1 glycosylase
type: Axiom
annotated source: GO_0000703
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110226

Cleavage of dihydrouracil by NTHL1 glycosylase
type: Axiom
annotated source: GO_0000703
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110227

GO_0000774
has db xref: Reactome:R-HSA-5252079

HSP110s exchange ATP for ADP on HSP70s:ADP
type: Axiom
annotated source: GO_0000774
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5252079

GO_0000824
has db xref: Reactome:R-HSA-1855185

I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: Axiom
annotated source: GO_0000824
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855185

GO_0000825
has db xref: Reactome:R-HSA-1855206

I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: Axiom
annotated source: GO_0000825
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855206

GO_0000827
has db xref: Reactome:R-HSA-1855181
has db xref: Reactome:R-HSA-1855223

I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
type: Axiom
annotated source: GO_0000827
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855181

I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
type: Axiom
annotated source: GO_0000827
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855223

GO_0000828
has db xref: Reactome:R-HSA-1855207
has db xref: Reactome:R-HSA-1855216
has db xref: Reactome:R-HSA-1855227

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
type: Axiom
annotated source: GO_0000828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855207

IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
type: Axiom
annotated source: GO_0000828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855216

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
type: Axiom
annotated source: GO_0000828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855227

GO_0000829
has db xref: Reactome:R-HSA-1855157
has db xref: Reactome:R-HSA-1855182
has db xref: Reactome:R-HSA-1855194

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
type: Axiom
annotated source: GO_0000829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855157

5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
type: Axiom
annotated source: GO_0000829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855182

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
type: Axiom
annotated source: GO_0000829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855194

GO_0001055
has db xref: Reactome:R-HSA-6814549
has db xref: Reactome:R-HSA-6814559

Pre-snRNA transcript initiation, Integrator binding, LEC binding
type: Axiom
annotated source: GO_0001055
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814549

Pre-snRNA is elongated and capped with 7-methylguanosine
type: Axiom
annotated source: GO_0001055
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814559

GO_0001056
has db xref: Reactome:R-HSA-1964482

RNA polymerase III transcribes microbial dsDNA to dsRNA
type: Axiom
annotated source: GO_0001056
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1964482

GO_0001512
has db xref: Reactome:R-HSA-8936519

NQO2:FAD dimer reduces quinones to hydroquinones
type: Axiom
annotated source: GO_0001512
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8936519

GO_0001517
has db xref: Reactome:R-HSA-2046222
has db xref: Reactome:R-HSA-3656269
has db xref: Reactome:R-HSA-6786012

CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG
type: Axiom
annotated source: GO_0001517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046222

Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG
type: Axiom
annotated source: GO_0001517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3656269

CHST4 transfers SO4(2-) from PAPS to Core 2 mucins
type: Axiom
annotated source: GO_0001517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786012

GO_0001537
has db xref: Reactome:R-HSA-2022063
has db xref: Reactome:R-HSA-3636919
has db xref: Reactome:R-HSA-6786034

CHST14 transfers SO4(2-) to GalNAc in dermatan or DS
type: Axiom
annotated source: GO_0001537
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022063

Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS
type: Axiom
annotated source: GO_0001537
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3636919

CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin
type: Axiom
annotated source: GO_0001537
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786034

GO_0001664
has db xref: Reactome:R-HSA-500717

Activation of GRIK3 homomer
type: Axiom
annotated source: GO_0001664
annotated property: hasDbXref
annotated target: Reactome:R-HSA-500717

GO_0001665
has db xref: Reactome:R-HSA-4084980
has db xref: Reactome:R-HSA-9603991
has db xref: Reactome:R-HSA-9846305

ST6GALNAC5,6 transfer Neu5Ac to GM1b
type: Axiom
annotated source: GO_0001665
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9846305

ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
type: Axiom
annotated source: GO_0001665
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4084980

ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG
type: Axiom
annotated source: GO_0001665
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603991

GO_0001671
has db xref: Reactome:R-HSA-5251955
has db xref: Reactome:R-HSA-5251959

HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
type: Axiom
annotated source: GO_0001671
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5251955

HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
type: Axiom
annotated source: GO_0001671
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5251959

GO_0001716
has db xref: Reactome:R-HSA-2160492

IL4I1:FAD oxidises L-Phe to kPPV
type: Axiom
annotated source: GO_0001716
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2160492

GO_0001727
has db xref: Reactome:R-HSA-428273
has db xref: Reactome:R-HSA-9695949

SPHK1 phosphorylates sphingoid
type: Axiom
annotated source: GO_0001727
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428273

SPHK2 phosphorylates sphingoid
type: Axiom
annotated source: GO_0001727
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9695949

GO_0001729
has db xref: Reactome:R-HSA-1638845

CERK phosphorylates CERA to form C1P
type: Axiom
annotated source: GO_0001729
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638845

GO_0001730
has db xref: Reactome:R-HSA-8983680
has db xref: Reactome:R-HSA-8985091
has db xref: Reactome:R-HSA-8985104

OAS1 produces oligoadenylates
type: Axiom
annotated source: GO_0001730
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983680

OAS3 produces oligoadenylates
type: Axiom
annotated source: GO_0001730
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8985091

OAS2 produces oligoadenylates
type: Axiom
annotated source: GO_0001730
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8985104

GO_0001733
has db xref: Reactome:R-HSA-9844587

GAL3ST1 transfers sulfate to GalCer,LacCer
type: Axiom
annotated source: GO_0001733
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9844587

GO_0001734
has db xref: Reactome:R-HSA-72095

Internal Methylation of mRNA
type: Axiom
annotated source: GO_0001734
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72095

GO_0001758
has db xref: Reactome:R-HSA-5362522
has db xref: Reactome:R-HSA-5696101

ALDHs oxidise atRAL to atRA
type: Axiom
annotated source: GO_0001758
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362522

ALDH8A1 oxidises 9cRAL to 9cRA
type: Axiom
annotated source: GO_0001758
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696101

GO_0002020
has db xref: Reactome:R-HSA-1297354

Acrosin Cleavage
type: Axiom
annotated source: GO_0002020
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1297354

GO_0002083
has db xref: Reactome:R-HSA-2162192

PHB and all-E-10PrP2 are combined into DHB by COQ2
type: Axiom
annotated source: GO_0002083
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162192

GO_0002151
has db xref: Reactome:R-HSA-9836998

GRSF1 unwinds quadruplex G regions in RNA
type: Axiom
annotated source: GO_0002151
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836998

GO_0002950
has db xref: Reactome:R-HSA-8959462

SAMD8 transfers phosphatidyl from PE onto C16DH CER
type: Axiom
annotated source: GO_0002950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8959462

GO_0003678
has db xref: Reactome:R-HSA-5693589

D-loop dissociation and strand annealing
type: Axiom
annotated source: GO_0003678
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693589

GO_0003689
has db xref: Reactome:R-HSA-174439
has db xref: Reactome:R-HSA-176264

Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
type: Axiom
annotated source: GO_0003689
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174439

Recruitment of the Rad9-Hus1-Rad1 complex to DNA
type: Axiom
annotated source: GO_0003689
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176264

GO_0003720
has db xref: Reactome:R-HSA-163090
has db xref: Reactome:R-HSA-164617

Elongation Of The Telomeric Chromosome End
type: Axiom
annotated source: GO_0003720
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163090

Elongation of Extended Telomeric Chromosome End
type: Axiom
annotated source: GO_0003720
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164617

GO_0003723
has db xref: Reactome:R-HSA-203922

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: GO_0003723
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203922

GO_0003724
has db xref: Reactome:R-HSA-72647
has db xref: Reactome:R-HSA-9770129
has db xref: Reactome:R-HSA-9770131
has db xref: Reactome:R-HSA-9770141
has db xref: Reactome:R-HSA-9770142
has db xref: Reactome:R-HSA-9770145

Cap-bound mRNA is activated by helicases
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72647

Formation of the Spliceosomal A complex
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770129

Formation of the Spliceosomal B* complex
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770131

Formation of the Spliceosomal C* complex
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770141

Formation of the Spliceosomal B complex
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770142

Formation of the Spliceosomal Bact complex
type: Axiom
annotated source: GO_0003724
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770145

GO_0003726
has db xref: Reactome:R-HSA-77614
has db xref: Reactome:R-HSA-77615

Deamination at C6 position of adenosine in Editosome (ADAR1)
type: Axiom
annotated source: GO_0003726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77614

Deamination at C6 position of adenosine in Editosome (ADAR2)
type: Axiom
annotated source: GO_0003726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77615

GO_0003743
has db xref: Reactome:R-HSA-72621
has db xref: Reactome:R-HSA-72697
has db xref: Reactome:R-HSA-72722

Ribosomal scanning
type: Axiom
annotated source: GO_0003743
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72621

Start codon recognition
type: Axiom
annotated source: GO_0003743
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72697

eIF2 activation
type: Axiom
annotated source: GO_0003743
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72722

GO_0003746
has db xref: Reactome:R-HSA-192704
has db xref: Reactome:R-HSA-192841

Synthesis of PB1-F2
type: Axiom
annotated source: GO_0003746
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192704

Viral Protein Synthesis
type: Axiom
annotated source: GO_0003746
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192841

GO_0003755
has db xref: Reactome:R-HSA-2022073
has db xref: Reactome:R-HSA-9626816

Procollagen triple helix formation
type: Axiom
annotated source: GO_0003755
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022073

PIN1 binds p-S345-NCF1
type: Axiom
annotated source: GO_0003755
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9626816

GO_0003756
has db xref: Reactome:R-HSA-8950113
has db xref: Reactome:R-HSA-8950183
has db xref: Reactome:R-HSA-8950456

IL12A binds IL12B
type: Axiom
annotated source: GO_0003756
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950113

IL12B binds IL23A
type: Axiom
annotated source: GO_0003756
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950183

IL12B dimerizes
type: Axiom
annotated source: GO_0003756
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950456

GO_0003774
has db xref: Reactome:R-HSA-1861595

Extension of pseudopodia by myosin-X in a PI3K dependent manner
type: Axiom
annotated source: GO_0003774
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1861595

GO_0003777
has db xref: Reactome:R-HSA-177479
has db xref: Reactome:R-HSA-265160
has db xref: Reactome:R-HSA-9610627

Axonal transport of NGF:Trk complexes
type: Axiom
annotated source: GO_0003777
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177479

Insulin secretory granule translocates to cell cortex
type: Axiom
annotated source: GO_0003777
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265160

KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane
type: Axiom
annotated source: GO_0003777
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9610627

GO_0003796
has db xref: Reactome:R-HSA-8862320

LYZ hydrolyzes peptidoglycans in the bacterial cell wall
type: Axiom
annotated source: GO_0003796
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8862320

GO_0003810
has db xref: Reactome:R-HSA-140851
has db xref: Reactome:R-HSA-6810894

fibrin multimer -> fibrin multimer, crosslinked + NH4+
type: Axiom
annotated source: GO_0003810
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140851

Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking
type: Axiom
annotated source: GO_0003810
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6810894

GO_0003827
has db xref: Reactome:R-HSA-964768

Addition of GlcNAc to the glycan on the A arm
type: Axiom
annotated source: GO_0003827
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964768

GO_0003828
has db xref: Reactome:R-HSA-1022133
has db xref: Reactome:R-HSA-4084978
has db xref: Reactome:R-HSA-422454
has db xref: Reactome:R-HSA-9845587

ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans
type: Axiom
annotated source: GO_0003828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1022133

ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues
type: Axiom
annotated source: GO_0003828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4084978

Polysialylation of NCAM1
type: Axiom
annotated source: GO_0003828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-422454

ST8SIA5 transfers Neu5Ac to gangliosides
type: Axiom
annotated source: GO_0003828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9845587

GO_0003829
has db xref: Reactome:R-HSA-914012
has db xref: Reactome:R-HSA-914018

GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
type: Axiom
annotated source: GO_0003829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-914012

Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
type: Axiom
annotated source: GO_0003829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-914018

GO_0003830
has db xref: Reactome:R-HSA-975926

Addition of a bifurcating GlcNAc to the N-glycan by MGAT3
type: Axiom
annotated source: GO_0003830
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975926

GO_0003831
has db xref: Reactome:R-HSA-1912352
has db xref: Reactome:R-HSA-2025723
has db xref: Reactome:R-HSA-2046265
has db xref: Reactome:R-HSA-2046298
has db xref: Reactome:R-HSA-3656230
has db xref: Reactome:R-HSA-4793956
has db xref: Reactome:R-HSA-9035949
has db xref: Reactome:R-HSA-9035950
has db xref: Reactome:R-HSA-975919

Galactosylation of Pre-NOTCH
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912352

B4GALTs transfer Gal to the N-glycan precursor
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2025723

B4GALTs transfer Gal to the keratan chain
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046265

B4GALTs transfer Gal to a branch of keratan
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046298

Defective B4GALT1 does not transfer Gal to the keratan chain
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3656230

Defective B4GALT1 does not add Gal to N-glycan
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4793956

Defective B4GALT1 does not transfer Gal to the N-glycan precursor
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035949

Defective B4GALT1 does not transfer Gal to a branch of keratan
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035950

Addition of galactose by beta 4-galactosyltransferases
type: Axiom
annotated source: GO_0003831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975919

GO_0003834
has db xref: Reactome:R-HSA-975635

BCMO1:Fe2+ cleaves betaC to atRAL
type: Axiom
annotated source: GO_0003834
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975635

GO_0003835
has db xref: Reactome:R-HSA-4085033
has db xref: Reactome:R-HSA-975902
has db xref: Reactome:R-HSA-977071

ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)
type: Axiom
annotated source: GO_0003835
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4085033

ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans
type: Axiom
annotated source: GO_0003835
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975902

ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
type: Axiom
annotated source: GO_0003835
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977071

GO_0003836
has db xref: Reactome:R-HSA-1022129
has db xref: Reactome:R-HSA-1912378
has db xref: Reactome:R-HSA-2046285
has db xref: Reactome:R-HSA-3656258
has db xref: Reactome:R-HSA-4084984
has db xref: Reactome:R-HSA-9603987
has db xref: Reactome:R-HSA-9605600
has db xref: Reactome:R-HSA-981497
has db xref: Reactome:R-HSA-9844860
has db xref: Reactome:R-HSA-9845538

ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1022129

Sialylation of Pre-NOTCH
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912378

The keratan chain can be capped by N-acetylneuraminic acid
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046285

Defective ST3GAL3 does not transfer SA to keratan
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3656258

ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4084984

ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603987

ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9605600

ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-981497

ST3GAL5 transfers NeuNAc to ceramides
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9844860

ST3GAL2,3 transfer Neu5Ac to gangliosides
type: Axiom
annotated source: GO_0003836
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9845538

GO_0003837
has db xref: Reactome:R-HSA-73591
has db xref: Reactome:R-HSA-73620

beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
type: Axiom
annotated source: GO_0003837
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73591

beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
type: Axiom
annotated source: GO_0003837
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73620

GO_0003839
has db xref: Reactome:R-HSA-1247922
has db xref: Reactome:R-HSA-6785928

GGCT transforms gGluCys to OPRO
type: Axiom
annotated source: GO_0003839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1247922

CHAC1,2 cleaves GSH to OPRO and CysGly
type: Axiom
annotated source: GO_0003839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6785928

GO_0003841
has db xref: Reactome:R-HSA-1482539
has db xref: Reactome:R-HSA-1482547
has db xref: Reactome:R-HSA-1482548
has db xref: Reactome:R-HSA-1482598
has db xref: Reactome:R-HSA-1482636
has db xref: Reactome:R-HSA-1482667
has db xref: Reactome:R-HSA-1482689
has db xref: Reactome:R-HSA-1482894
has db xref: Reactome:R-HSA-75885
has db xref: Reactome:R-HSA-8849345

1-acyl LPG is acylated to PG by LPGAT
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482539

1-acyl LPC is acylated to PC by LPCAT
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482547

1-acyl LPA is acylated to PA by AGPAT5 (OM)
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482548

1-acyl LPI is acylated to PI by MBOAT7
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482598

1-acyl LPS is acylated to PS by LPSAT
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482636

1-acyl LPE is acylated to PE by LPEAT
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482667

1-acyl LPG is acylated to PG by CRLS1 (IM)
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482689

CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482894

1-acyl LPA is acylated to PA by AGPAT (LPAAT)
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75885

LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine
type: Axiom
annotated source: GO_0003841
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849345

GO_0003842
has db xref: Reactome:R-HSA-6784399
has db xref: Reactome:R-HSA-70679

ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate
type: Axiom
annotated source: GO_0003842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784399

ALDH4A1 oxidises L-GluSS to Glu
type: Axiom
annotated source: GO_0003842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70679

GO_0003844
has db xref: Reactome:R-HSA-3322005
has db xref: Reactome:R-HSA-3322016
has db xref: Reactome:R-HSA-3322057
has db xref: Reactome:R-HSA-3878762

GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
type: Axiom
annotated source: GO_0003844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322005

GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a
type: Axiom
annotated source: GO_0003844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322016

GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
type: Axiom
annotated source: GO_0003844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322057

Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)
type: Axiom
annotated source: GO_0003844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3878762

GO_0003845
has db xref: Reactome:R-HSA-194023

HSD11B2,HSD11B1 dimer oxidise CORT to COR
type: Axiom
annotated source: GO_0003845
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194023

GO_0003846
has db xref: Reactome:R-HSA-5696448
has db xref: Reactome:R-HSA-6800334

AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG
type: Axiom
annotated source: GO_0003846
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696448

MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG
type: Axiom
annotated source: GO_0003846
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800334

GO_0003847
has db xref: Reactome:R-HSA-8869206

PAFAH2 hydrolyses PAF to lyso-PAF and acetate
type: Axiom
annotated source: GO_0003847
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8869206

GO_0003854
has db xref: Reactome:R-HSA-192097
has db xref: Reactome:R-HSA-193789
has db xref: Reactome:R-HSA-193816
has db xref: Reactome:R-HSA-196350
has db xref: Reactome:R-HSA-196372

7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
type: Axiom
annotated source: GO_0003854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192097

Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
type: Axiom
annotated source: GO_0003854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193789

Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
type: Axiom
annotated source: GO_0003854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193816

Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione
type: Axiom
annotated source: GO_0003854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196350

17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol
type: Axiom
annotated source: GO_0003854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196372

GO_0003857
has db xref: Reactome:R-HSA-193455
has db xref: Reactome:R-HSA-193508
has db xref: Reactome:R-HSA-389995
has db xref: Reactome:R-HSA-390251
has db xref: Reactome:R-HSA-508369
has db xref: Reactome:R-HSA-6809264
has db xref: Reactome:R-HSA-70837
has db xref: Reactome:R-HSA-77254
has db xref: Reactome:R-HSA-77283
has db xref: Reactome:R-HSA-77303
has db xref: Reactome:R-HSA-77312
has db xref: Reactome:R-HSA-77323
has db xref: Reactome:R-HSA-77331
has db xref: Reactome:R-HSA-77342

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193455

(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193508

3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389995

HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390251

alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508369

EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809264

alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70837

(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77254

(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77283

(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77303

(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77312

(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77323

(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77331

(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H
type: Axiom
annotated source: GO_0003857
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77342

GO_0003858
has db xref: Reactome:R-HSA-5696457
has db xref: Reactome:R-HSA-73912
has db xref: Reactome:R-HSA-73920

BDH2 dehydrogenates 3HBA
type: Axiom
annotated source: GO_0003858
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696457

acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+
type: Axiom
annotated source: GO_0003858
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73912

D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+
type: Axiom
annotated source: GO_0003858
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73920

GO_0003860
has db xref: Reactome:R-HSA-70881

beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
type: Axiom
annotated source: GO_0003860
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70881

GO_0003865
has db xref: Reactome:R-HSA-469659
has db xref: Reactome:R-HSA-9705713
has db xref: Reactome:R-HSA-9705714

SRD5A1 dehydrogenates TEST to DHTEST
type: Axiom
annotated source: GO_0003865
annotated property: hasDbXref
annotated target: Reactome:R-HSA-469659

SRD5A2 dehydrogenates TEST to DHTEST
type: Axiom
annotated source: GO_0003865
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9705713

SRD5A3 dehydrogenates TEST to DHTEST
type: Axiom
annotated source: GO_0003865
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9705714

GO_0003867
has db xref: Reactome:R-HSA-916855

PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
type: Axiom
annotated source: GO_0003867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-916855

GO_0003868
has db xref: Reactome:R-HSA-71163

p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
type: Axiom
annotated source: GO_0003868
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71163

GO_0003870
has db xref: Reactome:R-HSA-189442

ALAS condenses SUCC-CoA and Gly to form dALA
type: Axiom
annotated source: GO_0003870
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189442

GO_0003872
has db xref: Reactome:R-HSA-70467

D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
type: Axiom
annotated source: GO_0003872
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70467

GO_0003873
has db xref: Reactome:R-HSA-71802

D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP
type: Axiom
annotated source: GO_0003873
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71802

GO_0003874
has db xref: Reactome:R-HSA-1474184

DHNTP is dephosphorylated by PTPS to PTHP
type: Axiom
annotated source: GO_0003874
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474184

GO_0003876
has db xref: Reactome:R-HSA-76590

AMP + H2O => IMP + NH4+ (AMPD)
type: Axiom
annotated source: GO_0003876
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76590

GO_0003878
has db xref: Reactome:R-HSA-75848

ACLY tetramer transforms CIT to Ac-CoA
type: Axiom
annotated source: GO_0003878
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75848

GO_0003881
has db xref: Reactome:R-HSA-1482976

CDP-DAG is converted to PI by CDIPT
type: Axiom
annotated source: GO_0003881
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482976

GO_0003883
has db xref: Reactome:R-HSA-504054
has db xref: Reactome:R-HSA-73647

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]
type: Axiom
annotated source: GO_0003883
annotated property: hasDbXref
annotated target: Reactome:R-HSA-504054

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]
type: Axiom
annotated source: GO_0003883
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73647

GO_0003884
has db xref: Reactome:R-HSA-389821

glycine + O2 => glyoxylate + H2O2 + NH4+
type: Axiom
annotated source: GO_0003884
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389821

GO_0003887
has db xref: Reactome:R-HSA-110311
has db xref: Reactome:R-HSA-110317
has db xref: Reactome:R-HSA-110319
has db xref: Reactome:R-HSA-110368
has db xref: Reactome:R-HSA-111253
has db xref: Reactome:R-HSA-164505
has db xref: Reactome:R-HSA-164513
has db xref: Reactome:R-HSA-174427
has db xref: Reactome:R-HSA-174444
has db xref: Reactome:R-HSA-5358579
has db xref: Reactome:R-HSA-5649723
has db xref: Reactome:R-HSA-5649883
has db xref: Reactome:R-HSA-5653840
has db xref: Reactome:R-HSA-5655892
has db xref: Reactome:R-HSA-5655965
has db xref: Reactome:R-HSA-5656148
has db xref: Reactome:R-HSA-5656158
has db xref: Reactome:R-HSA-5687360
has db xref: Reactome:R-HSA-5687640
has db xref: Reactome:R-HSA-5691001
has db xref: Reactome:R-HSA-5693593
has db xref: Reactome:R-HSA-6782208
has db xref: Reactome:R-HSA-6786166
has db xref: Reactome:R-HSA-68950
has db xref: Reactome:R-HSA-69116
has db xref: Reactome:R-HSA-73932
has db xref: Reactome:R-HSA-9710480

POLZ extends translesion synthesis
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110311

Insertion of correct bases opposite the lesion by POLH
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110317

Elongation by POLH
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110319

POLD,POLE-mediated DNA strand displacement synthesis
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110368

POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111253

Synthesis of full-length duplex viral DNA with a discontinuous plus strand
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164505

3' PPT-primed initiation of plus-strand DNA synthesis
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164513

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174427

Formation of C-strand Okazaki fragments
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174444

DNA polymerase delta polymerizes DNA across single stranded gap
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358579

POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649723

POLB-mediated DNA strand displacement synthesis
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649883

POLD,POLE complete replication of damaged DNA after TLS
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653840

POLK incorporates dNMP opposite to damaged DNA base
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655892

POLK and POLZ cooperate in elongation of mispaired primer termini
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655965

POLI incorporates dNMP opposite to damaged DNA base
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656148

POLZ elongates POLI-incorporated dNMP
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656158

POLL or POLM extends aligned DNA DSB ends to fill gaps
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687360

POLQ extends annealed 3'-ssDNA overhangs in MMEJ
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687640

Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5691001

D-loop extension by DNA polymerases
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693593

Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782208

Translesion synthesis across unhooked ICL by POLN
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786166

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68950

Formation of Okazaki fragments
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69116

Resynthesis of excised residue by POLB
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73932

Decitabine triphosphate incorporates into DNA
type: Axiom
annotated source: GO_0003887
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9710480

GO_0003899
has db xref: Reactome:R-HSA-111264
has db xref: Reactome:R-HSA-167113
has db xref: Reactome:R-HSA-167115
has db xref: Reactome:R-HSA-167117
has db xref: Reactome:R-HSA-167121
has db xref: Reactome:R-HSA-167136
has db xref: Reactome:R-HSA-174425
has db xref: Reactome:R-HSA-203901
has db xref: Reactome:R-HSA-427366
has db xref: Reactome:R-HSA-5601926
has db xref: Reactome:R-HSA-6781824
has db xref: Reactome:R-HSA-68913
has db xref: Reactome:R-HSA-74986
has db xref: Reactome:R-HSA-75850
has db xref: Reactome:R-HSA-75869
has db xref: Reactome:R-HSA-75873
has db xref: Reactome:R-HSA-76576
has db xref: Reactome:R-HSA-9670149
has db xref: Reactome:R-HSA-9697084
has db xref: Reactome:R-HSA-9697085

Addition of nucleotides between position +11 and +30
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111264

Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167113

Addition of nucleotides between position +11 and +30 on HIV-1 transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167115

Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167117

Addition of the third nucleotide on the nascent HIV-1 transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167121

Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167136

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174425

Pol II mediated transcription of microRNA genes
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203901

Transcription of intergenic spacer of the rRNA gene
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427366

RNA polymerase II polymerizes primary piRNA transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601926

Active RNA Pol II complex transcribes lesion-containing DNA template
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6781824

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68913

Elongation of pre-rRNA transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74986

Addition of the third nucleotide on the nascent transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75850

Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75869

Addition of Nucleotides 5 through 9 on the growing Transcript
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75873

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76576

TERRA transcription
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9670149

Defective rpoB in Mtb RNAP transcribes RNA polyanion
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9697084

RNAP transcribes Mtb RNA polyanion
type: Axiom
annotated source: GO_0003899
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9697085

GO_0003906
has db xref: Reactome:R-HSA-110375
has db xref: Reactome:R-HSA-5649711
has db xref: Reactome:R-HSA-5649725

Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
type: Axiom
annotated source: GO_0003906
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110375

NEIL1,NEIL2 incises DNA strand 5' to the AP site
type: Axiom
annotated source: GO_0003906
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649711

POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
type: Axiom
annotated source: GO_0003906
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649725

GO_0003908
has db xref: Reactome:R-HSA-73892

MGMT/hAGT mediated DNA Damage Reversal
type: Axiom
annotated source: GO_0003908
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73892

GO_0003909
has db xref: Reactome:R-HSA-174456
has db xref: Reactome:R-HSA-175258
has db xref: Reactome:R-HSA-5358592
has db xref: Reactome:R-HSA-5649734
has db xref: Reactome:R-HSA-5651789
has db xref: Reactome:R-HSA-5651805
has db xref: Reactome:R-HSA-5687675
has db xref: Reactome:R-HSA-5690997
has db xref: Reactome:R-HSA-5693604
has db xref: Reactome:R-HSA-6782227
has db xref: Reactome:R-HSA-69173
has db xref: Reactome:R-HSA-73931

Joining of adjacent Okazaki fragments of the C-strand
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174456

2-LTR formation due to circularization of viral DNA
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-175258

DNA ligase I ligates single stranded nick in double stranded DNA
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358592

LIG3 ligates NEIL1,NEIL2-generated single strand break
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649734

LIG1 bound to POLB ligates SSB
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651789

LIG1 bound to APEX1 and PCNA ligates SSB
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651805

LIG3 ligates remaining SSBs in MMEJ
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687675

Ligation of newly synthesized repair patch to incised DNA in GG-NER
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690997

XRCC4:LIG4 ligates DNA DSB ends during NHEJ
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693604

Ligation of newly synthesized repair patch to incised DNA in TC-NER
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782227

Joining of adjacent Okazaki fragments
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69173

LIG3-mediated DNA ligation via the single-nucleotide replacement pathway
type: Axiom
annotated source: GO_0003909
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73931

GO_0003919
has db xref: Reactome:R-HSA-196929

FLAD1 phosphorylates FMN
type: Axiom
annotated source: GO_0003919
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196929

GO_0003920
has db xref: Reactome:R-HSA-514604

GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
type: Axiom
annotated source: GO_0003920
annotated property: hasDbXref
annotated target: Reactome:R-HSA-514604

GO_0003922
has db xref: Reactome:R-HSA-73792
has db xref: Reactome:R-HSA-9748957

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
type: Axiom
annotated source: GO_0003922
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73792

GMPS dimer transforms 6TXMP to 6TGMP
type: Axiom
annotated source: GO_0003922
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748957

GO_0003923
has db xref: Reactome:R-HSA-162836

uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide
type: Axiom
annotated source: GO_0003923
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162836

GO_0003924
has db xref: Reactome:R-HSA-1445143
has db xref: Reactome:R-HSA-1458485
has db xref: Reactome:R-HSA-156923
has db xref: Reactome:R-HSA-164381
has db xref: Reactome:R-HSA-165055
has db xref: Reactome:R-HSA-167415
has db xref: Reactome:R-HSA-170666
has db xref: Reactome:R-HSA-170685
has db xref: Reactome:R-HSA-170686
has db xref: Reactome:R-HSA-177501
has db xref: Reactome:R-HSA-203973
has db xref: Reactome:R-HSA-2130641
has db xref: Reactome:R-HSA-2130725
has db xref: Reactome:R-HSA-2584246
has db xref: Reactome:R-HSA-380979
has db xref: Reactome:R-HSA-392133
has db xref: Reactome:R-HSA-392212
has db xref: Reactome:R-HSA-418574
has db xref: Reactome:R-HSA-418582
has db xref: Reactome:R-HSA-421835
has db xref: Reactome:R-HSA-428941
has db xref: Reactome:R-HSA-432707
has db xref: Reactome:R-HSA-5333615
has db xref: Reactome:R-HSA-5389839
has db xref: Reactome:R-HSA-5389842
has db xref: Reactome:R-HSA-5419273
has db xref: Reactome:R-HSA-5419279
has db xref: Reactome:R-HSA-555065
has db xref: Reactome:R-HSA-5623513
has db xref: Reactome:R-HSA-5638006
has db xref: Reactome:R-HSA-5658231
has db xref: Reactome:R-HSA-5665809
has db xref: Reactome:R-HSA-5672017
has db xref: Reactome:R-HSA-5694527
has db xref: Reactome:R-HSA-6807877
has db xref: Reactome:R-HSA-6814833
has db xref: Reactome:R-HSA-8847534
has db xref: Reactome:R-HSA-8847883
has db xref: Reactome:R-HSA-8849082
has db xref: Reactome:R-HSA-8854173
has db xref: Reactome:R-HSA-8854255
has db xref: Reactome:R-HSA-8854329
has db xref: Reactome:R-HSA-8854604
has db xref: Reactome:R-HSA-8854612
has db xref: Reactome:R-HSA-8868661
has db xref: Reactome:R-HSA-8981353
has db xref: Reactome:R-HSA-8982020
has db xref: Reactome:R-HSA-8982021
has db xref: Reactome:R-HSA-8982025
has db xref: Reactome:R-HSA-9018814
has db xref: Reactome:R-HSA-9018826
has db xref: Reactome:R-HSA-9640195
has db xref: Reactome:R-HSA-9645598
has db xref: Reactome:R-HSA-9649736
has db xref: Reactome:R-HSA-983422

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GO_0003924
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983422

GO_0003934
has db xref: Reactome:R-HSA-1474146

GCH1 reduces GTP to dihydroneopterin triphosphate
type: Axiom
annotated source: GO_0003934
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474146

GO_0003937
has db xref: Reactome:R-HSA-73797

FAICAR => IMP + H2O
type: Axiom
annotated source: GO_0003937
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73797

GO_0003938
has db xref: Reactome:R-HSA-73794
has db xref: Reactome:R-HSA-9748945

IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
type: Axiom
annotated source: GO_0003938
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73794

IMPDH tetramers dehydrogenate 6TIMP to 6TXMP
type: Axiom
annotated source: GO_0003938
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748945

GO_0003939
has db xref: Reactome:R-HSA-5652195

SORD oxidizes D-sorbitol to Fru
type: Axiom
annotated source: GO_0003939
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5652195

GO_0003940
has db xref: Reactome:R-HSA-1678716
has db xref: Reactome:R-HSA-1793186
has db xref: Reactome:R-HSA-2090037
has db xref: Reactome:R-HSA-2206299
has db xref: Reactome:R-HSA-9036037
has db xref: Reactome:R-HSA-9036041

IDUA hydrolyses Heparan sulfate chain(1)
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678716

IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1793186

IDUA hydrolyses Heparan sulfate chain(6)
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2090037

Defective IDUA does not hydrolyse Heparan sulfate chain(6)
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2206299

Defective IDUA does not hydrolyse Heparan sulfate chain(1)
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036037

Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS
type: Axiom
annotated source: GO_0003940
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036041

GO_0003943
has db xref: Reactome:R-HSA-1606789
has db xref: Reactome:R-HSA-1793207
has db xref: Reactome:R-HSA-2282889
has db xref: Reactome:R-HSA-9036065

ARSB hydrolyses DS
type: Axiom
annotated source: GO_0003943
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606789

ARSB hydrolyses C4S/C6S chains
type: Axiom
annotated source: GO_0003943
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1793207

Defective ARSB does not hydrolyse C4S/C6S chains
type: Axiom
annotated source: GO_0003943
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2282889

Defective ARSB does not hydrolyse DS
type: Axiom
annotated source: GO_0003943
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036065

GO_0003947
has db xref: Reactome:R-HSA-8856223

B4GALNT1 dimer transfers GalNAc to gangliosides
type: Axiom
annotated source: GO_0003947
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8856223

GO_0003950
has db xref: Reactome:R-HSA-2187325
has db xref: Reactome:R-HSA-3640858
has db xref: Reactome:R-HSA-5651723
has db xref: Reactome:R-HSA-5687653
has db xref: Reactome:R-HSA-5688276
has db xref: Reactome:R-HSA-8938073
has db xref: Reactome:R-HSA-8948800
has db xref: Reactome:R-HSA-9686061
has db xref: Reactome:R-HSA-9729279

PARP1 ADP-ribosylates SMAD3 and SMAD4
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2187325

Tankyrase ADP-ribosylates AXIN
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3640858

PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651723

PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687653

SIRT4 transfers ADPRib to GLUD
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5688276

PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8938073

TNKS and TNKS2 PARylate PTEN
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948800

Nucleoprotein is ADP-ribosylated
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686061

Nucleoprotein is ADP-ribosylated
type: Axiom
annotated source: GO_0003950
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729279

GO_0003951
has db xref: Reactome:R-HSA-197198
has db xref: Reactome:R-HSA-8955030

NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
type: Axiom
annotated source: GO_0003951
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197198

NADK2 dimer phosphorylates NAD+ to NADP+
type: Axiom
annotated source: GO_0003951
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8955030

GO_0003952
has db xref: Reactome:R-HSA-197271

NADSYN1 hexamer amidates NAAD to NAD+
type: Axiom
annotated source: GO_0003952
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197271

GO_0003953
has db xref: Reactome:R-HSA-8870346
has db xref: Reactome:R-HSA-8938076

BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
type: Axiom
annotated source: GO_0003953
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8870346

CD38 hydrolyses NAD+ to NAM and ADP-ribose
type: Axiom
annotated source: GO_0003953
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8938076

GO_0003958
has db xref: Reactome:R-HSA-76494

POR reduces CYP450:Fe3+ to CYP450:Fe2+
type: Axiom
annotated source: GO_0003958
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76494

GO_0003959
has db xref: Reactome:R-HSA-9018867
has db xref: Reactome:R-HSA-9018901
has db xref: Reactome:R-HSA-9027625
has db xref: Reactome:R-HSA-9027631
has db xref: Reactome:R-HSA-9027632

5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2
type: Axiom
annotated source: GO_0003959
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018867

5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2
type: Axiom
annotated source: GO_0003959
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018901

5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3
type: Axiom
annotated source: GO_0003959
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027625

5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA
type: Axiom
annotated source: GO_0003959
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027631

5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA
type: Axiom
annotated source: GO_0003959
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027632

GO_0003960
has db xref: Reactome:R-HSA-6799722

TP53I3 oxidoreductase generates unstable semiquinones
type: Axiom
annotated source: GO_0003960
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799722

GO_0003964
has db xref: Reactome:R-HSA-164504
has db xref: Reactome:R-HSA-164520

Synthesis of minus strand strong stop DNA (-sssDNA)
type: Axiom
annotated source: GO_0003964
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164504

Minus strand DNA synthesis resumes
type: Axiom
annotated source: GO_0003964
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164520

GO_0003968
has db xref: Reactome:R-HSA-168280
has db xref: Reactome:R-HSA-168301
has db xref: Reactome:R-HSA-192624
has db xref: Reactome:R-HSA-192832
has db xref: Reactome:R-HSA-192851
has db xref: Reactome:R-HSA-192916
has db xref: Reactome:R-HSA-9681651
has db xref: Reactome:R-HSA-9681674
has db xref: Reactome:R-HSA-9681840
has db xref: Reactome:R-HSA-9682465
has db xref: Reactome:R-HSA-9682563
has db xref: Reactome:R-HSA-9685639
has db xref: Reactome:R-HSA-9685681
has db xref: Reactome:R-HSA-9694277
has db xref: Reactome:R-HSA-9694344
has db xref: Reactome:R-HSA-9694506
has db xref: Reactome:R-HSA-9694549
has db xref: Reactome:R-HSA-9694581
has db xref: Reactome:R-HSA-9694605
has db xref: Reactome:R-HSA-9694792
has db xref: Reactome:R-HSA-9828639
has db xref: Reactome:R-HSA-9834719
has db xref: Reactome:R-HSA-9834736
has db xref: Reactome:R-HSA-9837511

Priming and Initiation of Transcription
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168280

Elongation, Polyadenylation and Termination
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168301

cRNA Extension
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192624

Initiation of cRNA Synthesis
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192832

vRNA Extension
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192851

Initiation of vRNA Synthesis
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192916

nsp8 generates RNA primers
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9681651

nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9681674

RTC synthesizes SARS-CoV-1 plus strand genomic RNA
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9681840

RTC completes synthesis of the minus strand genomic RNA complement
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9682465

nsp12 misincorporates a nucleotide in nascent RNA minus strand
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9682563

Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9685639

Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9685681

nsp8 generates RNA primers
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694277

Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694344

Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694506

RTC completes synthesis of the minus strand genomic RNA complement
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694549

RTC synthesizes SARS-CoV-2 plus strand genomic RNA
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694581

nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694605

nsp12 misincorporates a nucleotide in nascent RNA minus strand
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694792

Transcription of respiratory syncytial virus subgenomic positive sense mRNAs
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9828639

Synthesis of negative sense genomic RNA of respiratory syncytial virus
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9834719

Synthesis of antigenomic RNA of human respiratory syncytial virus
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9834736

Abortive replication of hRSV A
type: Axiom
annotated source: GO_0003968
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9837511

GO_0003972
has db xref: Reactome:R-HSA-5696816

tRNA ligase complex ligates tRNA exons
type: Axiom
annotated source: GO_0003972
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696816

GO_0003973
has db xref: Reactome:R-HSA-389842
has db xref: Reactome:R-HSA-6787811

HAO1 tetramer oxidizes glycolate to glyoxylate
type: Axiom
annotated source: GO_0003973
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389842

HAO2 tetramer oxidises 2OH-PALM
type: Axiom
annotated source: GO_0003973
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6787811

GO_0003975
has db xref: Reactome:R-HSA-446191
has db xref: Reactome:R-HSA-4549334

Addition of N-acetyl-D-glucosamine to Dolichyl phosphate
type: Axiom
annotated source: GO_0003975
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446191

Defective DPAGT1 does not transfer GlcNAc to DOLP
type: Axiom
annotated source: GO_0003975
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4549334

GO_0003977
has db xref: Reactome:R-HSA-446204

GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine
type: Axiom
annotated source: GO_0003977
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446204

GO_0003978
has db xref: Reactome:R-HSA-5610036
has db xref: Reactome:R-HSA-70369

Defective GALE does not epimerise UDP-Gal to UDP-Glc
type: Axiom
annotated source: GO_0003978
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610036

GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc
type: Axiom
annotated source: GO_0003978
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70369

GO_0003979
has db xref: Reactome:R-HSA-173597

UDP-glucose is oxidised to UDP-glucuronate
type: Axiom
annotated source: GO_0003979
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173597

GO_0003980
has db xref: Reactome:R-HSA-548884

UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b
type: Axiom
annotated source: GO_0003980
annotated property: hasDbXref
annotated target: Reactome:R-HSA-548884

GO_0003983
has db xref: Reactome:R-HSA-70286

UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose
type: Axiom
annotated source: GO_0003983
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70286

GO_0003985
has db xref: Reactome:R-HSA-70844
has db xref: Reactome:R-HSA-73916
has db xref: Reactome:R-HSA-74181
has db xref: Reactome:R-HSA-8848215

alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
type: Axiom
annotated source: GO_0003985
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70844

2 acetyl-CoA <=> acetoacetyl-CoA + CoA
type: Axiom
annotated source: GO_0003985
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73916

acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
type: Axiom
annotated source: GO_0003985
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74181

ACAT2 condenses 2 Ac-CoA to form ACA-CoA
type: Axiom
annotated source: GO_0003985
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848215

GO_0003986
has db xref: Reactome:R-HSA-2066779
has db xref: Reactome:R-HSA-390304

Conversion of DHA-CoA to docosahexaenoic acid (DHA)
type: Axiom
annotated source: GO_0003986
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2066779

acetyl-CoA + H2O => acetate + CoASH
type: Axiom
annotated source: GO_0003986
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390304

GO_0003987
has db xref: Reactome:R-HSA-449911
has db xref: Reactome:R-HSA-71735
has db xref: Reactome:R-HSA-8875071

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
type: Axiom
annotated source: GO_0003987
annotated property: hasDbXref
annotated target: Reactome:R-HSA-449911

acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]
type: Axiom
annotated source: GO_0003987
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71735

ACSS3 ligates CoA to CH3COO-
type: Axiom
annotated source: GO_0003987
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875071

GO_0003988
has db xref: Reactome:R-HSA-390250
has db xref: Reactome:R-HSA-77271
has db xref: Reactome:R-HSA-77304
has db xref: Reactome:R-HSA-77309
has db xref: Reactome:R-HSA-77321
has db xref: Reactome:R-HSA-77329
has db xref: Reactome:R-HSA-77340
has db xref: Reactome:R-HSA-8874745

3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390250

3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77271

3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77304

3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77309

3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77321

3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77329

3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77340

ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH
type: Axiom
annotated source: GO_0003988
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874745

GO_0003989
has db xref: Reactome:R-HSA-200555
has db xref: Reactome:R-HSA-75851
has db xref: Reactome:R-HSA-8876889

acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate
type: Axiom
annotated source: GO_0003989
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200555

Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA
type: Axiom
annotated source: GO_0003989
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75851

Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA
type: Axiom
annotated source: GO_0003989
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876889

GO_0003990
has db xref: Reactome:R-HSA-372519

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Axiom
annotated source: GO_0003990
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372519

GO_0003993
has db xref: Reactome:R-HSA-196950

2xTRAP hydrolyzes FMN to RIB
type: Axiom
annotated source: GO_0003993
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196950

GO_0003994
has db xref: Reactome:R-HSA-450975
has db xref: Reactome:R-HSA-5690911
has db xref: Reactome:R-HSA-70971

isocitrate <=> citrate
type: Axiom
annotated source: GO_0003994
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450975

ACO1:4Fe-4S isomerises CIT to ISCIT
type: Axiom
annotated source: GO_0003994
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690911

citrate <=> isocitrate
type: Axiom
annotated source: GO_0003994
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70971

GO_0003995
has db xref: Reactome:R-HSA-109341
has db xref: Reactome:R-HSA-5695980
has db xref: Reactome:R-HSA-5695989
has db xref: Reactome:R-HSA-70800
has db xref: Reactome:R-HSA-70859
has db xref: Reactome:R-HSA-77263
has db xref: Reactome:R-HSA-77274
has db xref: Reactome:R-HSA-77299
has db xref: Reactome:R-HSA-77319
has db xref: Reactome:R-HSA-77327
has db xref: Reactome:R-HSA-77338
has db xref: Reactome:R-HSA-77345

dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109341

ACAD10 dehydrogenates S-2MPDA-CoA
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5695980

ACAD11 dehydrogenates BH-CoA
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5695989

alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70800

isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70859

lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77263

myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77274

palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77299

Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77319

Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77327

Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77338

Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2
type: Axiom
annotated source: GO_0003995
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77345

GO_0003997
has db xref: Reactome:R-HSA-192335
has db xref: Reactome:R-HSA-193369
has db xref: Reactome:R-HSA-2066787
has db xref: Reactome:R-HSA-390256

25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)
type: Axiom
annotated source: GO_0003997
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192335

25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
type: Axiom
annotated source: GO_0003997
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193369

Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA
type: Axiom
annotated source: GO_0003997
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2066787

hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
type: Axiom
annotated source: GO_0003997
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390256

GO_0003999
has db xref: Reactome:R-HSA-74213
has db xref: Reactome:R-HSA-9734193

APRT catalyzes the conversion of adenine to AMP
type: Axiom
annotated source: GO_0003999
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74213

Defective APRT does not convert adenine to AMP
type: Axiom
annotated source: GO_0003999
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9734193

GO_0004000
has db xref: Reactome:R-HSA-5693346

CECRI deaminates Ade-Rib to Ino
type: Axiom
annotated source: GO_0004000
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693346

GO_0004001
has db xref: Reactome:R-HSA-109624
has db xref: Reactome:R-HSA-9754974

(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)
type: Axiom
annotated source: GO_0004001
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109624

ADK phosphorylates RBV
type: Axiom
annotated source: GO_0004001
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9754974

GO_0004013
has db xref: Reactome:R-HSA-174401
has db xref: Reactome:R-HSA-5579084

AHCY:NAD+ tetramer hydrolyses AdoHcy
type: Axiom
annotated source: GO_0004013
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174401

Defective AHCY does not hydrolyse AdoHcy
type: Axiom
annotated source: GO_0004013
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5579084

GO_0004014
has db xref: Reactome:R-HSA-351222

S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2
type: Axiom
annotated source: GO_0004014
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351222

GO_0004016
has db xref: Reactome:R-HSA-164377
has db xref: Reactome:R-HSA-170676
has db xref: Reactome:R-HSA-381607
has db xref: Reactome:R-HSA-392129
has db xref: Reactome:R-HSA-5211224
has db xref: Reactome:R-HSA-5610727
has db xref: Reactome:R-HSA-9712183

Activated Adenylate cyclase catalyses cAMP synthesis
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164377

Adenylate cyclase converts ATP into cyclic AMP
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170676

Activated Adenylyl cyclase synthesizes cyclic AMP
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381607

Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392129

Anthrax cya catalyzes the conversion of ATP to cAMP
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211224

GPR161 promotes cAMP production in a G alpha(s)-dependent manner
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610727

ADCY3:GNAL:GTP converts ATP to cAMP
type: Axiom
annotated source: GO_0004016
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712183

GO_0004017
has db xref: Reactome:R-HSA-110141
has db xref: Reactome:R-HSA-110144
has db xref: Reactome:R-HSA-110145
has db xref: Reactome:R-HSA-74220

(d)ADP + ADP <=> (d)AMP + ATP (AK1)
type: Axiom
annotated source: GO_0004017
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110141

ADP + ADP <=> AMP + ATP [AK2]
type: Axiom
annotated source: GO_0004017
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110144

AMP + ATP <=> ADP + ADP [AK2]
type: Axiom
annotated source: GO_0004017
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110145

(d)AMP + ATP <=> (d)ADP + ADP (AK1)
type: Axiom
annotated source: GO_0004017
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74220

GO_0004019
has db xref: Reactome:R-HSA-111524

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
type: Axiom
annotated source: GO_0004019
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111524

GO_0004020
has db xref: Reactome:R-HSA-174389
has db xref: Reactome:R-HSA-3560785

PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
type: Axiom
annotated source: GO_0004020
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174389

Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS
type: Axiom
annotated source: GO_0004020
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3560785

GO_0004021
has db xref: Reactome:R-HSA-507749
has db xref: Reactome:R-HSA-507775
has db xref: Reactome:R-HSA-70523
has db xref: Reactome:R-HSA-70524

PXLP-K341-GPT2 transaminates PYR to form L-Ala
type: Axiom
annotated source: GO_0004021
annotated property: hasDbXref
annotated target: Reactome:R-HSA-507749

PXLP-K341-GPT2 transaminates L-Ala to form PYR
type: Axiom
annotated source: GO_0004021
annotated property: hasDbXref
annotated target: Reactome:R-HSA-507775

PXLP-K314-GPT transaminates L-Ala to form PYR
type: Axiom
annotated source: GO_0004021
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70523

PXLP-K314-GPT transaminates PYR to form L-Ala
type: Axiom
annotated source: GO_0004021
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70524

GO_0004022
has db xref: Reactome:R-HSA-2162078

abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+
type: Axiom
annotated source: GO_0004022
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162078

GO_0004024
has db xref: Reactome:R-HSA-71707

ethanol + NAD+ => acetaldehyde + NADH + H+
type: Axiom
annotated source: GO_0004024
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71707

GO_0004027
has db xref: Reactome:R-HSA-176494
has db xref: Reactome:R-HSA-176609

SULTs transfer (SO4)2- group to 27HCHOL
type: Axiom
annotated source: GO_0004027
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176494

cholesterol + PAPS => cholesterol sulfate + PAP
type: Axiom
annotated source: GO_0004027
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176609

GO_0004029
has db xref: Reactome:R-HSA-380608
has db xref: Reactome:R-HSA-389609
has db xref: Reactome:R-HSA-5692261
has db xref: Reactome:R-HSA-5696091
has db xref: Reactome:R-HSA-6808487
has db xref: Reactome:R-HSA-6808496
has db xref: Reactome:R-HSA-6813749
has db xref: Reactome:R-HSA-71691
has db xref: Reactome:R-HSA-71723

5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380608

ALDH3A2-2 oxidizes pristanal to pristanate
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389609

ALDH3A2-1 oxidises HD2NAL to PALM
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692261

ALDH1B1 tetramer oxidises CH3CHO to CH3COOH
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696091

ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6808487

ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6808496

ALDH1A1 oxidises GA to DGA
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6813749

acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71691

acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]
type: Axiom
annotated source: GO_0004029
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71723

GO_0004030
has db xref: Reactome:R-HSA-5692283
has db xref: Reactome:R-HSA-5696080
has db xref: Reactome:R-HSA-6808464

ALD3A1 oxidises 4HPCP to CXPA
type: Axiom
annotated source: GO_0004030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692283

ALDH3B1 oxidises HXAL to PALM
type: Axiom
annotated source: GO_0004030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696080

ALDH3B2 oxidises HXAL to PALM
type: Axiom
annotated source: GO_0004030
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6808464

GO_0004031
has db xref: Reactome:R-HSA-3204311

AOX1 oxidises PXL to PDXate
type: Axiom
annotated source: GO_0004031
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3204311

GO_0004032
has db xref: Reactome:R-HSA-196060
has db xref: Reactome:R-HSA-5652172

Reduction of isocaproaldehyde to 4-methylpentan-1-ol
type: Axiom
annotated source: GO_0004032
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196060

AKR1B1 reduces Glc to D-sorbitol
type: Axiom
annotated source: GO_0004032
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5652172

GO_0004033
has db xref: Reactome:R-HSA-192033
has db xref: Reactome:R-HSA-192036
has db xref: Reactome:R-HSA-192067
has db xref: Reactome:R-HSA-192160
has db xref: Reactome:R-HSA-193746
has db xref: Reactome:R-HSA-193755
has db xref: Reactome:R-HSA-193758
has db xref: Reactome:R-HSA-193781
has db xref: Reactome:R-HSA-193800
has db xref: Reactome:R-HSA-193821
has db xref: Reactome:R-HSA-193824
has db xref: Reactome:R-HSA-193841
has db xref: Reactome:R-HSA-198845
has db xref: Reactome:R-HSA-2855252
has db xref: Reactome:R-HSA-5423637
has db xref: Reactome:R-HSA-5692232
has db xref: Reactome:R-HSA-9027531
has db xref: Reactome:R-HSA-9027562
has db xref: Reactome:R-HSA-9027598
has db xref: Reactome:R-HSA-9027600

4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192033

5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192036

4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192067

5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192160

4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193746

4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193755

5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193758

5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193781

5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193800

4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193821

4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193824

5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193841

CYB5A:heme reduces Asc.- to AscH-
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198845

AKRs reduce RBP2:atRAL to RBP2:atROL
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2855252

AKR dimers reduce AFBDHO to AFBDOH
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423637

AKR1A1 oxidises BaPtDHD to BaP-7,8-dione
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692232

Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027531

Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027562

Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027598

Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3
type: Axiom
annotated source: GO_0004033
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027600

GO_0004035
has db xref: Reactome:R-HSA-8878787

ALPI dimer hydrolyses phosphate monoesters
type: Axiom
annotated source: GO_0004035
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8878787

GO_0004042
has db xref: Reactome:R-HSA-70542

glutamate + acetyl CoA => N-acetyl glutamate + CoA
type: Axiom
annotated source: GO_0004042
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70542

GO_0004043
has db xref: Reactome:R-HSA-70941

alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
type: Axiom
annotated source: GO_0004043
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70941

GO_0004044
has db xref: Reactome:R-HSA-73815

5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
type: Axiom
annotated source: GO_0004044
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73815

GO_0004046
has db xref: Reactome:R-HSA-5433074
has db xref: Reactome:R-HSA-5579081
has db xref: Reactome:R-HSA-9638046
has db xref: Reactome:R-HSA-9753944

ACY1:Zn2+ dimer hydrolyses mercapturic acids
type: Axiom
annotated source: GO_0004046
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5433074

Defective ACY1 does not hydrolyse mercapturic acids
type: Axiom
annotated source: GO_0004046
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5579081

ACY3:Zn2+ dimer hydrolyses mercapturic acids
type: Axiom
annotated source: GO_0004046
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638046

ACY1:Zn2+ dimer deacetylates NAC to L-Cys
type: Axiom
annotated source: GO_0004046
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753944

GO_0004047
has db xref: Reactome:R-HSA-5693977

AMT transfers NH2CH2 from GCSH:SAMDLL to THF
type: Axiom
annotated source: GO_0004047
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693977

GO_0004051
has db xref: Reactome:R-HSA-265296
has db xref: Reactome:R-HSA-266051
has db xref: Reactome:R-HSA-9018858
has db xref: Reactome:R-HSA-9018859
has db xref: Reactome:R-HSA-9018863
has db xref: Reactome:R-HSA-9018894
has db xref: Reactome:R-HSA-9020251
has db xref: Reactome:R-HSA-9020255
has db xref: Reactome:R-HSA-9020256
has db xref: Reactome:R-HSA-9020259
has db xref: Reactome:R-HSA-9020264
has db xref: Reactome:R-HSA-9020277
has db xref: Reactome:R-HSA-9020278
has db xref: Reactome:R-HSA-9020282
has db xref: Reactome:R-HSA-9024997
has db xref: Reactome:R-HSA-9025995
has db xref: Reactome:R-HSA-9025996
has db xref: Reactome:R-HSA-9025999
has db xref: Reactome:R-HSA-9026005
has db xref: Reactome:R-HSA-9026405
has db xref: Reactome:R-HSA-9027624
has db xref: Reactome:R-HSA-9027628
has db xref: Reactome:R-HSA-9027633

Arachidonic acid is oxidised to 5S-HpETE by ALOX5
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265296

5S-HpETE is dehydrated to LTA4 by ALOX5
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-266051

ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018858

ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018859

ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018863

ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018894

ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020251

ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020255

ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020256

ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020259

ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020264

ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020277

ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020278

ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020282

ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024997

ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9025995

ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9025996

ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9025999

ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026005

ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026405

ALOX5 oxidises DHA to 7-HDHA
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027624

ALOX5 oxidises EPA to 5-HEPE
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027628

ALOX5 oxidises DPAn-3 to 7-HDPAn-3
type: Axiom
annotated source: GO_0004051
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027633

GO_0004052
has db xref: Reactome:R-HSA-2161948
has db xref: Reactome:R-HSA-2161950
has db xref: Reactome:R-HSA-2161964
has db xref: Reactome:R-HSA-9024983
has db xref: Reactome:R-HSA-9025957
has db xref: Reactome:R-HSA-9026006
has db xref: Reactome:R-HSA-9026007

Arachidonic acid is converted to 12-oxoETE by ALOX12
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161948

Arachidonic acid is oxidised to 12R-HpETE by ALOX12B
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161950

Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161964

ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024983

ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9025957

ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026006

ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3
type: Axiom
annotated source: GO_0004052
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026007

GO_0004053
has db xref: Reactome:R-HSA-452036
has db xref: Reactome:R-HSA-70569

arginine + H2O => ornithine + urea [ARG2]
type: Axiom
annotated source: GO_0004053
annotated property: hasDbXref
annotated target: Reactome:R-HSA-452036

arginine + H2O => ornithine + urea [ARG1]
type: Axiom
annotated source: GO_0004053
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70569

GO_0004055
has db xref: Reactome:R-HSA-70577

ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
type: Axiom
annotated source: GO_0004055
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70577

GO_0004056
has db xref: Reactome:R-HSA-70573

argininosuccinate <=> fumarate + arginine
type: Axiom
annotated source: GO_0004056
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70573

GO_0004058
has db xref: Reactome:R-HSA-209859
has db xref: Reactome:R-HSA-209924

Decarboxylation of 5-hydroxytryptophan forms serotonin
type: Axiom
annotated source: GO_0004058
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209859

Dopa is decarboxylated to dopamine
type: Axiom
annotated source: GO_0004058
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209924

GO_0004059
has db xref: Reactome:R-HSA-209792

N-acetylation of serotonin
type: Axiom
annotated source: GO_0004059
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209792

GO_0004060
has db xref: Reactome:R-HSA-174963
has db xref: Reactome:R-HSA-174967
has db xref: Reactome:R-HSA-9753676

NAT1 acetylation
type: Axiom
annotated source: GO_0004060
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174963

NAT2 acetylation
type: Axiom
annotated source: GO_0004060
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174967

NAT1,2 acetylate APAP-Cys to APAP-Mer
type: Axiom
annotated source: GO_0004060
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753676

GO_0004061
has db xref: Reactome:R-HSA-71189

AFMID hydrolyses NFK to L-KYN
type: Axiom
annotated source: GO_0004061
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71189

GO_0004062
has db xref: Reactome:R-HSA-158468
has db xref: Reactome:R-HSA-158849
has db xref: Reactome:R-HSA-158860
has db xref: Reactome:R-HSA-159358
has db xref: Reactome:R-HSA-176474
has db xref: Reactome:R-HSA-176585
has db xref: Reactome:R-HSA-176646

SULT1A1 dimer sulfonates PARA to PARA-SO4
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158468

Phenol can form a sulfate conjugate
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158849

SULT1A1 dimer sulfonates NHABP
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158860

SULT1A3,4 dimers sulfate DA to DAOS
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159358

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176474

3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176585

p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
type: Axiom
annotated source: GO_0004062
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176646

GO_0004066
has db xref: Reactome:R-HSA-70599

aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
type: Axiom
annotated source: GO_0004066
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70599

GO_0004067
has db xref: Reactome:R-HSA-6797627

ASPG hydrolyses L-Asn to L-Asp
type: Axiom
annotated source: GO_0004067
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6797627

GO_0004069
has db xref: Reactome:R-HSA-70581
has db xref: Reactome:R-HSA-70592
has db xref: Reactome:R-HSA-70596
has db xref: Reactome:R-HSA-70613

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
type: Axiom
annotated source: GO_0004069
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70581

PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate
type: Axiom
annotated source: GO_0004069
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70592

GOT2 dimer deaminates L-Asp
type: Axiom
annotated source: GO_0004069
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70596

GOT2 transaminates oxaloacetate and glutamate
type: Axiom
annotated source: GO_0004069
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70613

GO_0004070
has db xref: Reactome:R-HSA-73573

CAD hexamer transforms CAP to N-carb-L-Asp
type: Axiom
annotated source: GO_0004070
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73573

GO_0004074
has db xref: Reactome:R-HSA-189384

BLVRA:Zn2+, BLVRB reduce BV to BIL
type: Axiom
annotated source: GO_0004074
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189384

GO_0004081
has db xref: Reactome:R-HSA-5696197

NUDT2 hydrolyses GP4G to GTP, GMP
type: Axiom
annotated source: GO_0004081
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696197

GO_0004082
has db xref: Reactome:R-HSA-6798335

BPGM dimer isomerises 1,3BPG to 2,3BPG
type: Axiom
annotated source: GO_0004082
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6798335

GO_0004084
has db xref: Reactome:R-HSA-508179
has db xref: Reactome:R-HSA-508189
has db xref: Reactome:R-HSA-70723
has db xref: Reactome:R-HSA-70724

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]
type: Axiom
annotated source: GO_0004084
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508179

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
type: Axiom
annotated source: GO_0004084
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508189

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
type: Axiom
annotated source: GO_0004084
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70723

leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
type: Axiom
annotated source: GO_0004084
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70724

GO_0004087
has db xref: Reactome:R-HSA-70555

2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]
type: Axiom
annotated source: GO_0004087
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70555

GO_0004088
has db xref: Reactome:R-HSA-73577

CAD hexamer transforms L-Gln to CAP
type: Axiom
annotated source: GO_0004088
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73577

GO_0004089
has db xref: Reactome:R-HSA-1237045
has db xref: Reactome:R-HSA-1237047
has db xref: Reactome:R-HSA-1237059
has db xref: Reactome:R-HSA-1237081
has db xref: Reactome:R-HSA-1475017
has db xref: Reactome:R-HSA-1475022
has db xref: Reactome:R-HSA-1475025
has db xref: Reactome:R-HSA-1475026
has db xref: Reactome:R-HSA-1475028
has db xref: Reactome:R-HSA-1475032
has db xref: Reactome:R-HSA-1475435
has db xref: Reactome:R-HSA-1475436

Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237045

CA4:Zn2+ hydrates CO2 to HCO3-
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237047

CA4:Zn2+ dehydrates HCO3- to CO2
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237059

Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237081

Carbonic anhydrase dehydrates bicarbonate (plasma membrane)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475017

Carbonic anhydrase dehydrates bicarbonate (cytosol)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475022

Carbonic anhydrase hydrates carbon dioxide (plasma membrane)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475025

Carbonic anhydrase hydrates carbon dioxide (cytosol)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475026

Carbonic anhydrase dehydrates bicarbonate (mitochondria)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475028

Carbonic anhydrase hydrates carbon dioxide (mitochondria)
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475032

CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475435

CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2
type: Axiom
annotated source: GO_0004089
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475436

GO_0004090
has db xref: Reactome:R-HSA-8937419

CBR3 reduces DOX to DOXOL
type: Axiom
annotated source: GO_0004090
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8937419

GO_0004092
has db xref: Reactome:R-HSA-390284
has db xref: Reactome:R-HSA-390291

propionyl-CoA + carnitine => propionylcarnitine + CoASH
type: Axiom
annotated source: GO_0004092
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390284

acetyl-CoA + carnitine => acetylcarnitine + CoASH
type: Axiom
annotated source: GO_0004092
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390291

GO_0004095
has db xref: Reactome:R-HSA-200406
has db xref: Reactome:R-HSA-200410

CPT1A,B transfers PALM to CAR
type: Axiom
annotated source: GO_0004095
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200406

palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine
type: Axiom
annotated source: GO_0004095
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200410

GO_0004096
has db xref: Reactome:R-HSA-1222704
has db xref: Reactome:R-HSA-76031

KatG reduces H2O2
type: Axiom
annotated source: GO_0004096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222704

2 H2O2 => O2 + 2 H2O
type: Axiom
annotated source: GO_0004096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76031

GO_0004098
has db xref: Reactome:R-HSA-1606807
has db xref: Reactome:R-HSA-9840949

ARSA removes sulfate from PSAP(195-273):Sulfatide
type: Axiom
annotated source: GO_0004098
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606807

ARSA removes sulfate from SM3
type: Axiom
annotated source: GO_0004098
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840949

GO_0004102
has db xref: Reactome:R-HSA-264622

Cho is acetylated to AcCho by CHAT
type: Axiom
annotated source: GO_0004102
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264622

GO_0004103
has db xref: Reactome:R-HSA-1483004

Cho is phosphorylated to PCho by CHK dimer
type: Axiom
annotated source: GO_0004103
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483004

GO_0004105
has db xref: Reactome:R-HSA-1483081

PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
type: Axiom
annotated source: GO_0004105
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483081

GO_0004108
has db xref: Reactome:R-HSA-70975

Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA
type: Axiom
annotated source: GO_0004108
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70975

GO_0004109
has db xref: Reactome:R-HSA-189421

CPO transforms COPRO3 to PPGEN9
type: Axiom
annotated source: GO_0004109
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189421

GO_0004111
has db xref: Reactome:R-HSA-200318
has db xref: Reactome:R-HSA-200326

creatine + ATP => phosphocreatine + ADP [CKB,CKM]
type: Axiom
annotated source: GO_0004111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200318

creatine + ATP => phosphocreatine + ADP [CK octamer]
type: Axiom
annotated source: GO_0004111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200326

GO_0004114
has db xref: Reactome:R-HSA-162425

p-S295-PDE3B hydrolyses cAMP to AMP
type: Axiom
annotated source: GO_0004114
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162425

GO_0004115
has db xref: Reactome:R-HSA-111962
has db xref: Reactome:R-HSA-418553
has db xref: Reactome:R-HSA-9629675
has db xref: Reactome:R-HSA-9644869
has db xref: Reactome:R-HSA-9705507
has db xref: Reactome:R-HSA-9708261

PDE4A,C,D hydrolyse cAMP
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111962

cAMP degradation by Phosphodiesterases
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418553

PDE3A hydrolyses cAMP to AMP
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9629675

p-S54-PDE4B hydrolyses cAMP
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9644869

PDE3B hydrolyses cAMP to AMP
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9705507

PDE4A hydrolyses cAMP to AMP
type: Axiom
annotated source: GO_0004115
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708261

GO_0004117
has db xref: Reactome:R-HSA-111955

cAMP hydrolysis by Cam-PDE 1
type: Axiom
annotated source: GO_0004117
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111955

GO_0004122
has db xref: Reactome:R-HSA-1614524

PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
type: Axiom
annotated source: GO_0004122
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1614524

GO_0004123
has db xref: Reactome:R-HSA-1614583

PXLP-K212-CTH cleaves L-Cystathionine
type: Axiom
annotated source: GO_0004123
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1614583

GO_0004126
has db xref: Reactome:R-HSA-73608
has db xref: Reactome:R-HSA-83677
has db xref: Reactome:R-HSA-9817513

(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)
type: Axiom
annotated source: GO_0004126
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73608

C4 deamination of cytidine
type: Axiom
annotated source: GO_0004126
annotated property: hasDbXref
annotated target: Reactome:R-HSA-83677

AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine
type: Axiom
annotated source: GO_0004126
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9817513

GO_0004128
has db xref: Reactome:R-HSA-198824
has db xref: Reactome:R-HSA-6806831

CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
type: Axiom
annotated source: GO_0004128
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198824

CYB5Rs reduce MetHb to HbA
type: Axiom
annotated source: GO_0004128
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6806831

GO_0004129
has db xref: Reactome:R-HSA-163214

Electron transfer from reduced cytochrome c to molecular oxygen
type: Axiom
annotated source: GO_0004129
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163214

GO_0004132
has db xref: Reactome:R-HSA-73596

dCMP + H2O => dUMP + NH4+
type: Axiom
annotated source: GO_0004132
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73596

GO_0004134
has db xref: Reactome:R-HSA-71552

limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
type: Axiom
annotated source: GO_0004134
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71552

GO_0004135
has db xref: Reactome:R-HSA-71593

((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
type: Axiom
annotated source: GO_0004135
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71593

GO_0004139
has db xref: Reactome:R-HSA-6787321

DERA cleaves dR5P to GA3P and CH3CHO
type: Axiom
annotated source: GO_0004139
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6787321

GO_0004140
has db xref: Reactome:R-HSA-196773
has db xref: Reactome:R-HSA-9837337

COASY phosphorylates DP-CoA
type: Axiom
annotated source: GO_0004140
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196773

DCAKD phosphorylates DP-CoA
type: Axiom
annotated source: GO_0004140
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9837337

GO_0004142
has db xref: Reactome:R-HSA-1482961
has db xref: Reactome:R-HSA-1482973

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
type: Axiom
annotated source: GO_0004142
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482961

CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
type: Axiom
annotated source: GO_0004142
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482973

GO_0004143
has db xref: Reactome:R-HSA-426240

DAG kinase produces phosphatidic acid from DAG
type: Axiom
annotated source: GO_0004143
annotated property: hasDbXref
annotated target: Reactome:R-HSA-426240

GO_0004144
has db xref: Reactome:R-HSA-1482889
has db xref: Reactome:R-HSA-549192
has db xref: Reactome:R-HSA-75900
has db xref: Reactome:R-HSA-8848580

DAG is acylated to TAG by DGAT1/2
type: Axiom
annotated source: GO_0004144
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482889

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]
type: Axiom
annotated source: GO_0004144
annotated property: hasDbXref
annotated target: Reactome:R-HSA-549192

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
type: Axiom
annotated source: GO_0004144
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75900

DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG
type: Axiom
annotated source: GO_0004144
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848580

GO_0004145
has db xref: Reactome:R-HSA-351207
has db xref: Reactome:R-HSA-351208

Spermine => N-acetylated spermine
type: Axiom
annotated source: GO_0004145
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351207

Spermidine => N-acetylated spermidine
type: Axiom
annotated source: GO_0004145
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351208

GO_0004146
has db xref: Reactome:R-HSA-1497794

Salvage - BH2 is reduced to BH4 by DHFR
type: Axiom
annotated source: GO_0004146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1497794

GO_0004148
has db xref: Reactome:R-HSA-1222412
has db xref: Reactome:R-HSA-5694018

lpdC dimer reactivates dlaT
type: Axiom
annotated source: GO_0004148
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222412

DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate
type: Axiom
annotated source: GO_0004148
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694018

GO_0004151
has db xref: Reactome:R-HSA-73571

CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO
type: Axiom
annotated source: GO_0004151
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73571

GO_0004152
has db xref: Reactome:R-HSA-73569

DHODH:FMN oxidises (S)-DHO to orotate
type: Axiom
annotated source: GO_0004152
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73569

GO_0004155
has db xref: Reactome:R-HSA-71130

q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
type: Axiom
annotated source: GO_0004155
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71130

GO_0004157
has db xref: Reactome:R-HSA-73589
has db xref: Reactome:R-HSA-73618

5,6-dihydrouracil + H2O => beta-ureidopropionate
type: Axiom
annotated source: GO_0004157
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73589

5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
type: Axiom
annotated source: GO_0004157
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73618

GO_0004161
has db xref: Reactome:R-HSA-191322
has db xref: Reactome:R-HSA-9717834

FDPS dimer transfers IPPP to DMAPP
type: Axiom
annotated source: GO_0004161
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191322

GGPS1 hexamer transfers IPPP to DMAPP
type: Axiom
annotated source: GO_0004161
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717834

GO_0004163
has db xref: Reactome:R-HSA-191414

MVD decarboxylates MVA5PP to IPPP
type: Axiom
annotated source: GO_0004163
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191414

GO_0004164
has db xref: Reactome:R-HSA-5358484

DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2
type: Axiom
annotated source: GO_0004164
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358484

GO_0004165
has db xref: Reactome:R-HSA-109338
has db xref: Reactome:R-HSA-6809808

Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA
type: Axiom
annotated source: GO_0004165
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109338

ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA
type: Axiom
annotated source: GO_0004165
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809808

GO_0004168
has db xref: Reactome:R-HSA-446195
has db xref: Reactome:R-HSA-4755600

DOLK phosphorylates DCHOL to DOLP
type: Axiom
annotated source: GO_0004168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446195

Defective DOLK does not phosphorylate DCHOL
type: Axiom
annotated source: GO_0004168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4755600

GO_0004169
has db xref: Reactome:R-HSA-5615556
has db xref: Reactome:R-HSA-5615604
has db xref: Reactome:R-HSA-5615637

Defective POMT2 does not transfer Man from Dol-P-Man to DAG1
type: Axiom
annotated source: GO_0004169
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5615556

Defective POMT1 does not transfer Man from Dol-P-Man to DAG1
type: Axiom
annotated source: GO_0004169
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5615604

POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)
type: Axiom
annotated source: GO_0004169
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5615637

GO_0004170
has db xref: Reactome:R-HSA-73666

dUTP + H2O => dUMP + pyrophosphate
type: Axiom
annotated source: GO_0004170
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73666

GO_0004174
has db xref: Reactome:R-HSA-169270

ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2
type: Axiom
annotated source: GO_0004174
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169270

GO_0004175
has db xref: Reactome:R-HSA-1168640
has db xref: Reactome:R-HSA-1234159
has db xref: Reactome:R-HSA-1236935
has db xref: Reactome:R-HSA-1236970
has db xref: Reactome:R-HSA-1251997
has db xref: Reactome:R-HSA-1433374
has db xref: Reactome:R-HSA-1504193
has db xref: Reactome:R-HSA-174058
has db xref: Reactome:R-HSA-174105
has db xref: Reactome:R-HSA-174202
has db xref: Reactome:R-HSA-174203
has db xref: Reactome:R-HSA-174255
has db xref: Reactome:R-HSA-180573
has db xref: Reactome:R-HSA-180603
has db xref: Reactome:R-HSA-187574
has db xref: Reactome:R-HSA-188191
has db xref: Reactome:R-HSA-193682
has db xref: Reactome:R-HSA-209061
has db xref: Reactome:R-HSA-211715
has db xref: Reactome:R-HSA-2130282
has db xref: Reactome:R-HSA-2213200
has db xref: Reactome:R-HSA-264458
has db xref: Reactome:R-HSA-353125
has db xref: Reactome:R-HSA-3640874
has db xref: Reactome:R-HSA-3928656
has db xref: Reactome:R-HSA-450466
has db xref: Reactome:R-HSA-4608855
has db xref: Reactome:R-HSA-4641256
has db xref: Reactome:R-HSA-4641260
has db xref: Reactome:R-HSA-5358340
has db xref: Reactome:R-HSA-5358460
has db xref: Reactome:R-HSA-5362448
has db xref: Reactome:R-HSA-5387392
has db xref: Reactome:R-HSA-5607724
has db xref: Reactome:R-HSA-5607731
has db xref: Reactome:R-HSA-5610754
has db xref: Reactome:R-HSA-5610757
has db xref: Reactome:R-HSA-5610758
has db xref: Reactome:R-HSA-5610760
has db xref: Reactome:R-HSA-5635854
has db xref: Reactome:R-HSA-5635868
has db xref: Reactome:R-HSA-5658430
has db xref: Reactome:R-HSA-5668481
has db xref: Reactome:R-HSA-5668520
has db xref: Reactome:R-HSA-5687112
has db xref: Reactome:R-HSA-5693081
has db xref: Reactome:R-HSA-6784628
has db xref: Reactome:R-HSA-6784676
has db xref: Reactome:R-HSA-68825
has db xref: Reactome:R-HSA-68948
has db xref: Reactome:R-HSA-69016
has db xref: Reactome:R-HSA-69600
has db xref: Reactome:R-HSA-74730
has db xref: Reactome:R-HSA-75825
has db xref: Reactome:R-HSA-8849797
has db xref: Reactome:R-HSA-8850992
has db xref: Reactome:R-HSA-8852354
has db xref: Reactome:R-HSA-8854044
has db xref: Reactome:R-HSA-8854071
has db xref: Reactome:R-HSA-8866553
has db xref: Reactome:R-HSA-8866858
has db xref: Reactome:R-HSA-8932355
has db xref: Reactome:R-HSA-8934819
has db xref: Reactome:R-HSA-8939801
has db xref: Reactome:R-HSA-8952408
has db xref: Reactome:R-HSA-8957265
has db xref: Reactome:R-HSA-9008110
has db xref: Reactome:R-HSA-9008475
has db xref: Reactome:R-HSA-9009362
has db xref: Reactome:R-HSA-9010096
has db xref: Reactome:R-HSA-9011313
has db xref: Reactome:R-HSA-9604642
has db xref: Reactome:R-HSA-9614271
has db xref: Reactome:R-HSA-9755303
has db xref: Reactome:R-HSA-9755306
has db xref: Reactome:R-HSA-9762096
has db xref: Reactome:R-HSA-983150
has db xref: Reactome:R-HSA-983158

Ubiquitinated IkB is degraded
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168640

Proteasome proteolyzes ub-HIF-alpha
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1234159

Proteasomal cleavage of substrate
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1236935

Proteasomal clevage of exogenous antigen
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1236970

Cleavage of ERBB4m80 by gamma-scretase complex
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1251997

Processing of SCF isoform 1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433374

Ubiquitinated DVL is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1504193

Degradation of multiubiquitinated Cdh1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174058

Degradation of multiubiquitinated cell cycle proteins
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174105

Degradation of multiubiquitinated Securin
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174202

SCF-mediated degradation of Emi1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174203

Degradation multiubiquitinated Cyclin A
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174255

Degradation of ubiquitinated CD4
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180573

Proteosome-mediated degradation of APOBEC3G
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180603

Degradation of ubiquitinated p27/p21 by the 26S proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187574

APC/C:Cdh1-mediated degradation of Skp2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188191

gamma-secretase cleaves the p75NTR transmembrane domain
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193682

Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209061

Proteasome mediated degradation of PAK-2p34
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211715

Degradation of ubiquitinated beta catenin by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130282

Release of endostatin-like peptides
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2213200

Proteasome mediated degradation of COP1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264458

26S proteosome degrades ODC holoenzyme complex
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-353125

Ub-RibC-AXIN is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3640874

gamma-secretase cleaves EPHB2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928656

AUF1:mRNA complex is destroyed
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450466

PRICKLE1 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4608855

Ubiquitinated AXIN is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4641256

Ubiquitinated DVL1 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4641260

Autoproteolytic cleavage of Hh precursors
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358340

HPE SHH variants don't undergo autoproteolytic cleavage
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358460

Hh C-terminal fragments are degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362448

processing defective Hh variants are degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5387392

26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607724

26S proteasome processes p-7S-p100:RELB to form p52:RELB
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607731

GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610754

GLI2 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610757

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610758

GLI1 is degraded by the proteasome after ubiquitination by ITCH
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610760

GLI2,3 are degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5635854

ub-GLI is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5635868

NF1 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5658430

Protesomal degradation of K48polyUb-TRAF3
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668481

26Sproteasome degrades K48polyUb-NIK
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668520

MAPK6 is degraded by the 26S proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687112

FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693081

PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784628

PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784676

Ubiquitinated geminin is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68825

Ubiquitinated Orc1 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68948

Ubiquitinated Cdc6 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69016

Proteolytic degradation of ubiquitinated-Cdc25A
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69600

Insulin degradation
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74730

Proteasome mediated degradation of Cyclin D1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75825

Membrane proteases cleave Profilaggrin producing Filaggrin
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849797

Proteasome degrades polyubiquitinated PTEN
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8850992

GTSE1 facilitates proteasome-mediated degradation of TP53
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852354

Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854044

Proteasome-mediated degradation of PolyUb-FBXL7
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854071

misfolded CFTR is degraded by the 26S proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8866553

CFTR F508del is degraded by the 26S proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8866858

26S proteasome degrades Ub-NFE2L2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8932355

Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8934819

26S proteasome degrades PolyUb-RUNX2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8939801

Polyubiquitinated RUNX3 is degraded by the proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8952408

26S proteasome degrades TP73 polyubiquitinated by ITCH
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8957265

Proteasome degrades polyubiquitinated RUNX2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9008110

Proteasome degrades polyubiquitinated RUNX2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9008475

Proteasome degrades PolyUb-RUNX2
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9009362

Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9010096

Proteasome degrades ubiquitinated ROBO3.1
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9011313

Proteasome degrades ubiquitinated NICD4
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604642

Autocleavage of ADGRG6
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9614271

26S proteasome degrades HIFalpha
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755303

ub UBXN7 is degraded by the 26S proteasome
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755306

Ub,pS335,S338,T NFE2L2 is degraded
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9762096

Proteasomal cleavage of substrate
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983150

Trimming of peptides in ER
type: Axiom
annotated source: GO_0004175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983158

GO_0004176
has db xref: Reactome:R-HSA-9698929
has db xref: Reactome:R-HSA-9838004
has db xref: Reactome:R-HSA-9838081
has db xref: Reactome:R-HSA-9838289
has db xref: Reactome:R-HSA-9839059
has db xref: Reactome:R-HSA-9839105
has db xref: Reactome:R-HSA-9839113
has db xref: Reactome:R-HSA-9839146
has db xref: Reactome:R-HSA-9839751

pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698929

LONP1 degrades mitochondrial inner membrane proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9838004

LONP1 degrades mitochondrial matrix proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9838081

CLPXP degrades mitochondrial matrix proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9838289

AFG3L2:SPG7 degrades SMDT1 (EMRE)
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839059

AFG3L2 degrades mitochondrial matrix proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839105

AFG3L2 degrades mitochondrial inner membrane proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839113

YME1L1 degrades mitochondrial inner membrane proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839146

YME1L1 degrades mitochondrial intermembrane space proteins
type: Axiom
annotated source: GO_0004176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839751

GO_0004177
has db xref: Reactome:R-HSA-1236954
has db xref: Reactome:R-HSA-2534096
has db xref: Reactome:R-HSA-8851929
has db xref: Reactome:R-HSA-983162

Trimming of peptides by IRAP in endocytic vesicles
type: Axiom
annotated source: GO_0004177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1236954

METAP1/2 demethylates GNAT1
type: Axiom
annotated source: GO_0004177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534096

AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41)
type: Axiom
annotated source: GO_0004177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851929

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
type: Axiom
annotated source: GO_0004177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983162

GO_0004180
has db xref: Reactome:R-HSA-1247910
has db xref: Reactome:R-HSA-9753632

CNDP2:2Mn2+ dimer hydrolyses CysGly
type: Axiom
annotated source: GO_0004180
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1247910

CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly
type: Axiom
annotated source: GO_0004180
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753632

GO_0004181
has db xref: Reactome:R-HSA-2022378
has db xref: Reactome:R-HSA-2022379
has db xref: Reactome:R-HSA-2028294
has db xref: Reactome:R-HSA-8852809
has db xref: Reactome:R-HSA-8866105
has db xref: Reactome:R-HSA-8955712
has db xref: Reactome:R-HSA-9023159
has db xref: Reactome:R-HSA-9023163

ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022378

ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022379

Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028294

CPN, CPB2 cleave C3a, C5a
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852809

CCPs deglutamylate tubulin
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8866105

SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8955712

Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87))
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023159

Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)
type: Axiom
annotated source: GO_0004181
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023163

GO_0004185
has db xref: Reactome:R-HSA-158251

prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer
type: Axiom
annotated source: GO_0004185
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158251

GO_0004190
has db xref: Reactome:R-HSA-157353
has db xref: Reactome:R-HSA-157640
has db xref: Reactome:R-HSA-2022403
has db xref: Reactome:R-HSA-2022412
has db xref: Reactome:R-HSA-2065357
has db xref: Reactome:R-HSA-2220988
has db xref: Reactome:R-HSA-373705
has db xref: Reactome:R-HSA-9013361
has db xref: Reactome:R-HSA-9017817
has db xref: Reactome:R-HSA-9604294

NEXT1 is cleaved to produce NICD1
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-157353

NEXT2 is cleaved to produce NICD2
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-157640

Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022403

Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022412

Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2065357

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2220988

Caspase cleavage of DCC
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-373705

NEXT3 is cleaved to produce NICD3
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013361

Gamma-secretase cleaves YBX1:NOTCH3
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9017817

Gamma-secretase cleaves NOTCH4
type: Axiom
annotated source: GO_0004190
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604294

GO_0004197
has db xref: Reactome:R-HSA-114252
has db xref: Reactome:R-HSA-114259
has db xref: Reactome:R-HSA-114261
has db xref: Reactome:R-HSA-1236948
has db xref: Reactome:R-HSA-139898
has db xref: Reactome:R-HSA-139952
has db xref: Reactome:R-HSA-1678920
has db xref: Reactome:R-HSA-1678981
has db xref: Reactome:R-HSA-201595
has db xref: Reactome:R-HSA-201603
has db xref: Reactome:R-HSA-201608
has db xref: Reactome:R-HSA-201611
has db xref: Reactome:R-HSA-201622
has db xref: Reactome:R-HSA-201628
has db xref: Reactome:R-HSA-201629
has db xref: Reactome:R-HSA-201630
has db xref: Reactome:R-HSA-201631
has db xref: Reactome:R-HSA-201634
has db xref: Reactome:R-HSA-201636
has db xref: Reactome:R-HSA-201637
has db xref: Reactome:R-HSA-201639
has db xref: Reactome:R-HSA-201640
has db xref: Reactome:R-HSA-2028692
has db xref: Reactome:R-HSA-2028697
has db xref: Reactome:R-HSA-202917
has db xref: Reactome:R-HSA-202939
has db xref: Reactome:R-HSA-202947
has db xref: Reactome:R-HSA-202960
has db xref: Reactome:R-HSA-202966
has db xref: Reactome:R-HSA-202967
has db xref: Reactome:R-HSA-202969
has db xref: Reactome:R-HSA-211186
has db xref: Reactome:R-HSA-211190
has db xref: Reactome:R-HSA-211651
has db xref: Reactome:R-HSA-212552
has db xref: Reactome:R-HSA-2130336
has db xref: Reactome:R-HSA-2130349
has db xref: Reactome:R-HSA-2130504
has db xref: Reactome:R-HSA-2130706
has db xref: Reactome:R-HSA-2562564
has db xref: Reactome:R-HSA-264865
has db xref: Reactome:R-HSA-264871
has db xref: Reactome:R-HSA-3465448
has db xref: Reactome:R-HSA-350158
has db xref: Reactome:R-HSA-350318
has db xref: Reactome:R-HSA-350319
has db xref: Reactome:R-HSA-350651
has db xref: Reactome:R-HSA-351849
has db xref: Reactome:R-HSA-351871
has db xref: Reactome:R-HSA-351876
has db xref: Reactome:R-HSA-351877
has db xref: Reactome:R-HSA-351894
has db xref: Reactome:R-HSA-351901
has db xref: Reactome:R-HSA-351913
has db xref: Reactome:R-HSA-351936
has db xref: Reactome:R-HSA-352268
has db xref: Reactome:R-HSA-418845
has db xref: Reactome:R-HSA-418846
has db xref: Reactome:R-HSA-418852
has db xref: Reactome:R-HSA-448703
has db xref: Reactome:R-HSA-5357828
has db xref: Reactome:R-HSA-5634228
has db xref: Reactome:R-HSA-5660663
has db xref: Reactome:R-HSA-5681987
has db xref: Reactome:R-HSA-5682377
has db xref: Reactome:R-HSA-6814387
has db xref: Reactome:R-HSA-9012556
has db xref: Reactome:R-HSA-9013895
has db xref: Reactome:R-HSA-933532
has db xref: Reactome:R-HSA-9603534
has db xref: Reactome:R-HSA-9647632
has db xref: Reactome:R-HSA-9647680
has db xref: Reactome:R-HSA-9647999
has db xref: Reactome:R-HSA-9684273
has db xref: Reactome:R-HSA-9684309
has db xref: Reactome:R-HSA-9684321
has db xref: Reactome:R-HSA-9684336
has db xref: Reactome:R-HSA-9684340
has db xref: Reactome:R-HSA-9684351
has db xref: Reactome:R-HSA-9684352

Cleavage of Procaspase-3 by the apoptosome
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114252

Cleavage of Procaspase9 to caspase9
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114259

Cleavage of Procaspase-7 by the apoptosome
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114261

Antigen processing by cathepsin S in endosoytic vesicle
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1236948

Caspase-8 activates BID by cleavage
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139898

Caspase-8 processing in the DISC
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139952

TLR processing at low pH
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678920

TLR9 processing at neutral pH
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678981

Caspase-mediated cleavage of plakophilin-1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201595

Caspase-mediated cleavage of PKC theta
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201603

Caspase-mediated cleavage of alpha adducin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201608

Caspase-mediated cleavage of Rock-1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201611

Caspase-mediated cleavage of gelsolin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201622

Caspase-mediated cleavage of vimentin at DSVD (85)
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201628

Caspase-mediated cleavage of Tau
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201629

Caspase-mediated cleavage of Acinus
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201630

Caspase-mediated cleavage of Desmoglein 3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201631

Caspase-mediated cleavage of FADK 1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201634

Caspase-mediated cleavage of Desmoplakin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201636

Caspase-mediated cleavage of plectin-1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201637

Caspase-mediated cleavage of GAS2
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201639

Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201640

Cleavage of p-STK4 (p-MST1) by caspase 3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028692

Cleavage of p-STK3 (p-MST2) by caspase 3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028697

Caspase-mediated cleavage of Desmoglein 1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202917

Caspase-mediated cleavage of E-Cadherin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202939

Caspase mediated cleavage of APC
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202947

Caspase mediated cleavage of C-IAP1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202960

Caspase mediated cleavage of HIP-55
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202966

Caspase mediated cleavage of alpha-II-Fodrin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202967

Caspase mediated cleavage of beta-catenin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202969

Cleavage of DFF45 (224) by caspase-3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211186

Caspase 3-mediated cleavage of DFF45 (117)
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211190

Cleavage of PAK-2 at 212
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211651

Caspase 3-mediated cleavage of PKC delta
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212552

Initial proteolyis of Ii by aspartic proteases to lip22
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130336

Generation of CLIP from lip10
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130349

Cleavage of lip22 to lip10
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130504

MHC class II antigen processing
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130706

Caspase-8 processing within TLR4 complex
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2562564

Caspase-mediated cleavage of Lamin A
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264865

Caspase-mediated cleavage of Lamin B1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264871

Caspase-8 and FLIP(L) processing at DISC
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3465448

LGMN degrades GC
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350158

Caspase-mediated cleavage of vimentin at TNLD (429)
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350318

Caspase mediated cleavage of vimentin at IDVD (259)
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350319

Caspase-mediated cleavage of MASK
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350651

Caspase-mediated cleavage of Etk
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351849

Caspase-mediated cleavage of Z0-2
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351871

Caspase-mediated cleavage of occludin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351876

Caspase-mediated cleavage of Desmoglein 2
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351877

Caspase mediated cleavage of BAP31
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351894

Caspase-mediated cleavage of MST3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351901

Caspase-mediated cleavage of TJP1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351913

Caspase-mediated cleavage of claspin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351936

Cleavage of Satb1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-352268

Activation of caspase-3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418845

Caspase cleavage of UNC5A
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418846

Caspase cleavage of UNC5B
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418852

Interleukin-1 family precursors are cleaved by caspase-1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-448703

RIPK1 is cleaved by CASP8
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357828

TRAF1 is cleaved by caspases
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5634228

Caspase-8 cleaves IL1B precursor
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660663

LC3 is cleaved by ATG4
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5681987

LC3 de-lipidation by ATG4
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682377

CASP14 cleaves filaggrin
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814387

IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012556

Caspase-8 processing within TLR3 complex
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013895

Processing of caspases
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-933532

Unknown caspase cleaves NTRK3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603534

CASP3 cleaves GSDME
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647632

CASP1 cleaves GSDMD
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647680

RCE1 cleaves S-Farn proRAS proteins
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647999

3CLp cleaves pp1a
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684273

3CLp cleaves nsp6-11
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684309

nsp3 cleaves nsp1-4
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684321

nsp1-4 cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684336

3CLp cleaves pp1ab
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684340

pp1a cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684351

nsp3-4 cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684352

CASP3 cleaves GSDMD
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686088

RIPK3 is cleaved by CASP8
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686930

RIPK1 variant is not cleaved by CASP8
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9693929

nsp1-4 cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694338

pp1a cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694377

3CLp cleaves pp1a
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694441

3CLp cleaves nsp6-11
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694551

nsp3-4 cleaves itself
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694601

nsp3 cleaves nsp1-4
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694625

3CLp cleaves pp1ab
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694732

RIPK1 is cleaved by CASP8:FLIP(L)
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9697750

CASP4, CASP5 cleave GSDMD
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9710101

SARS-CoV-2 3CLpro dimer cleaves TAB1
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729704

SARS-CoV-2 nsp3 cleaves IRF3
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729730

SARS-CoV-2 3CLpro dimer cleaves NLRP12
type: Axiom
annotated source: GO_0004197
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729741

GO_0004198
has db xref: Reactome:R-HSA-8848658
has db xref: Reactome:R-HSA-8863012

CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins
type: Axiom
annotated source: GO_0004198
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848658

Calpain cleaves p35 to p25
type: Axiom
annotated source: GO_0004198
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863012

GO_0004222
has db xref: Reactome:R-HSA-1168777
has db xref: Reactome:R-HSA-1251992
has db xref: Reactome:R-HSA-1299476
has db xref: Reactome:R-HSA-1299478
has db xref: Reactome:R-HSA-1454757
has db xref: Reactome:R-HSA-1454822
has db xref: Reactome:R-HSA-1458433
has db xref: Reactome:R-HSA-1474196
has db xref: Reactome:R-HSA-1474210
has db xref: Reactome:R-HSA-1474213
has db xref: Reactome:R-HSA-1564112
has db xref: Reactome:R-HSA-1564117
has db xref: Reactome:R-HSA-1564120
has db xref: Reactome:R-HSA-1564142
has db xref: Reactome:R-HSA-1564143
has db xref: Reactome:R-HSA-1564164
has db xref: Reactome:R-HSA-1564169
has db xref: Reactome:R-HSA-1564179
has db xref: Reactome:R-HSA-1564184
has db xref: Reactome:R-HSA-1592310
has db xref: Reactome:R-HSA-1655851
has db xref: Reactome:R-HSA-177946
has db xref: Reactome:R-HSA-181567
has db xref: Reactome:R-HSA-194793
has db xref: Reactome:R-HSA-194796
has db xref: Reactome:R-HSA-194800
has db xref: Reactome:R-HSA-194808
has db xref: Reactome:R-HSA-194809
has db xref: Reactome:R-HSA-194818
has db xref: Reactome:R-HSA-2002428
has db xref: Reactome:R-HSA-2002440
has db xref: Reactome:R-HSA-2022141
has db xref: Reactome:R-HSA-2168046
has db xref: Reactome:R-HSA-2168982
has db xref: Reactome:R-HSA-2179402
has db xref: Reactome:R-HSA-2473584
has db xref: Reactome:R-HSA-2473594
has db xref: Reactome:R-HSA-2473596
has db xref: Reactome:R-HSA-2484882
has db xref: Reactome:R-HSA-2485111
has db xref: Reactome:R-HSA-2485148
has db xref: Reactome:R-HSA-2514790
has db xref: Reactome:R-HSA-2514831
has db xref: Reactome:R-HSA-2533874
has db xref: Reactome:R-HSA-2533944
has db xref: Reactome:R-HSA-2533950
has db xref: Reactome:R-HSA-2533965
has db xref: Reactome:R-HSA-2533970
has db xref: Reactome:R-HSA-2534240
has db xref: Reactome:R-HSA-2534248
has db xref: Reactome:R-HSA-2537499
has db xref: Reactome:R-HSA-264758
has db xref: Reactome:R-HSA-3371385
has db xref: Reactome:R-HSA-3788075
has db xref: Reactome:R-HSA-3791149
has db xref: Reactome:R-HSA-3791155
has db xref: Reactome:R-HSA-3791295
has db xref: Reactome:R-HSA-3791319
has db xref: Reactome:R-HSA-381435
has db xref: Reactome:R-HSA-381518
has db xref: Reactome:R-HSA-381537
has db xref: Reactome:R-HSA-3827958
has db xref: Reactome:R-HSA-3828025
has db xref: Reactome:R-HSA-4086205
has db xref: Reactome:R-HSA-420818
has db xref: Reactome:R-HSA-4224014
has db xref: Reactome:R-HSA-5228578
has db xref: Reactome:R-HSA-5250606
has db xref: Reactome:R-HSA-5250892
has db xref: Reactome:R-HSA-5250962
has db xref: Reactome:R-HSA-5250978
has db xref: Reactome:R-HSA-5333671
has db xref: Reactome:R-HSA-5362793
has db xref: Reactome:R-HSA-5694082
has db xref: Reactome:R-HSA-6784620
has db xref: Reactome:R-HSA-8867344
has db xref: Reactome:R-HSA-8874122
has db xref: Reactome:R-HSA-8874187
has db xref: Reactome:R-HSA-8874192
has db xref: Reactome:R-HSA-8874194

MMPs cleave HB-EGF
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624272

ADAMTS13 cleaves VWF multimer
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9822532

ADAMTS13 variant does not cleave VWF multimer
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9824402

OMA1 cleaves DELE1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840408

OMA1 self-cleaves
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840532

OMA1 hydrolyzes YME1L1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840564

ADAMTS13 cleaves VWF variant multimer
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9844241

Metalloprotease cleavage of GHR
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168777

Cleavage of P-ERBB4jmA isoforms by ADAM17
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1251992

MPP cleaves targeting peptide (presequence) of inner membrane precursors
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299476

MPP cleaves targeting peptide (presequence) of matrix precursors
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299478

Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1454757

Collagen type I degradation by MMP1,2,8,13, PRSS2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1454822

Collagen type I degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1458433

Collagen type II degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474196

Collagen type III degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474210

Collagen type III degradation by MMP1,8,9,13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474213

Collagen type VI degradation by MMP2,9,11
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564112

Collagen type XIV degradation by MMP9,13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564117

Collagen type VII degradation by MMP1,2,3
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564120

Collagen type IV degradation by MMP2,3,4,9,10,12
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564142

Collagen type X degradation by MMP1,2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564143

Collagen type V degradation by MMP2,9,10
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564164

Collagen type VIII degradation by MMP1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564169

Collagen type XI degradation by MMP1,2,3,9
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564179

Collagen type IX degradation by MMP3,13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1564184

Aggrecan degradation by ADAMTSs
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592310

S2P hydrolyzes SREBP1A,1C,2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1655851

Pro-EGF is cleaved to form mature EGF
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177946

botC LC cleaves target cell STX1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-181567

botC LC cleaves target cell SNAP25
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194793

botB LC cleaves target cell VAMP2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194796

botE LC cleaves target cell SNAP25
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194800

botF LC cleaves target cell VAMP1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194808

botD LC cleaves target cell VAMP1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194809

botA LC cleaves target cell SNAP25
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194818

Removal of fibrillar collagen N-propeptides
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2002428

Removal of fibrillar collagen C-propeptides
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2002440

Prolysyl oxidase activation
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022141

Collagen type XII degradation by MMP12
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2168046

Collagen type XVI degradation by MMP9
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2168982

Active MMP3 can cleave pro-HBEGF to form active HBEGF
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2179402

Collagen type III degradation by MMP15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2473584

Collagen type II degradation by MMP15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2473594

Collagen type I degradation by MMP15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2473596

Collagen type X degradation by MMP3, 13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2484882

Collagen type III degradation by MMP10
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2485111

Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2485148

Elastin degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514790

Fibrillin-1 degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514831

Laminin-511 degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2533874

Fibronectin degradation by MMP10
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2533944

Fibronectin degradation by MMP14, TMPRSS6
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2533950

NID1 degradation by MMP14, MMP15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2533965

NID1 degradation by MMP3, 7
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2533970

HSPG2 (perlecan) degradation by MMP14, MMP15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534240

DCN (decorin) degradation by MMP2, MMP3, MMP7
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534248

Gelatin degradation by MMP19
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2537499

BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264758

TNF- is cleaved by ADAM17 (TACE)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3371385

Brevican degradation by ADAMTS4, ADAMTS5
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3788075

Brevican degradation by MMP1, 2, 3, 7,8,10,13,19
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3791149

Laminin-322 degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3791155

Aggrecan degradation by MMP1,2,3,7,9,12,13
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3791295

NID1 degradation by MMP19
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3791319

Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381435

PAAP-A proteolyzes IGF:IGFBP4
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381518

PAPP-A2 proteolyzes IGF:IGFBP5:ALS
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381537

E-cadherin degradation by MMP9, KLK7
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3827958

DCN (decorin) degradation by MMP14
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3828025

OPN (osteopontin) degradation by MMP3, MMP7
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4086205

MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-420818

E-cadherin degradation by ADAM10, ADAM15
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4224014

tetX LC cleaves target cell VAMP2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5228578

botD LC cleaves target cell VAMP2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250606

botF LC cleaves target cell VAMP2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250892

botG LC cleaves target cell VAMP2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250962

botG LC cleaves target cell VAMP1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250978

CLCAs self cleave
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5333671

Hh-Np is cleaved by ADAM17 to promote ligand shedding
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362793

XK:KEL:Zn2+ cleaves EDN3
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694082

MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784620

OMA1 hydrolyses OPA1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8867344

MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874122

MBTPS2 (S2P) cleaves CREB3L2
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874187

MBTPS2 (S2P) cleaves CREB3
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874192

MBTPS2 (S2P) cleaves CREB3L1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874194

MBTPS2 (S2P) cleaves CREB3L4
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874195

MBTPS2 (S2P) cleaves CREB3L3
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874201

ECE1 cleaves EDN1(53-90)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876868

ECE2 cleaves EDN1(53-90)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877620

MMP2 cleaves OPTC
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940554

MMP7 cleaves OPTC
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940561

THOP1 cleaves oligopeptide fragment (8-16aa)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940641

Neurolysin degrades neurotensin
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940959

MMP13 cleaves OPTC
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8942302

MMP2, MMP9 cleave SCUBE3
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8943959

PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949649

AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949659

YME1L1 proteolyzes unassembled proSMDT1
type: Axiom
annotated source: GO_0004222
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949668

GO_0004252
has db xref: Reactome:R-HSA-114697
has db xref: Reactome:R-HSA-1181152
has db xref: Reactome:R-HSA-139893
has db xref: Reactome:R-HSA-140599
has db xref: Reactome:R-HSA-140664
has db xref: Reactome:R-HSA-140696
has db xref: Reactome:R-HSA-140700
has db xref: Reactome:R-HSA-140736
has db xref: Reactome:R-HSA-140769
has db xref: Reactome:R-HSA-140777
has db xref: Reactome:R-HSA-140823
has db xref: Reactome:R-HSA-140840
has db xref: Reactome:R-HSA-140870
has db xref: Reactome:R-HSA-141026
has db xref: Reactome:R-HSA-141040
has db xref: Reactome:R-HSA-1454843
has db xref: Reactome:R-HSA-1474197
has db xref: Reactome:R-HSA-1566962
has db xref: Reactome:R-HSA-1566979
has db xref: Reactome:R-HSA-1566981
has db xref: Reactome:R-HSA-158137
has db xref: Reactome:R-HSA-158164
has db xref: Reactome:R-HSA-158300
has db xref: Reactome:R-HSA-158311
has db xref: Reactome:R-HSA-158313
has db xref: Reactome:R-HSA-158333
has db xref: Reactome:R-HSA-158419
has db xref: Reactome:R-HSA-158744
has db xref: Reactome:R-HSA-158747
has db xref: Reactome:R-HSA-158750
has db xref: Reactome:R-HSA-158766
has db xref: Reactome:R-HSA-158925
has db xref: Reactome:R-HSA-158942
has db xref: Reactome:R-HSA-158982
has db xref: Reactome:R-HSA-1592270
has db xref: Reactome:R-HSA-1592278
has db xref: Reactome:R-HSA-1592297
has db xref: Reactome:R-HSA-1592314
has db xref: Reactome:R-HSA-1592316
has db xref: Reactome:R-HSA-1592362
has db xref: Reactome:R-HSA-1592371
has db xref: Reactome:R-HSA-1592398
has db xref: Reactome:R-HSA-1592436
has db xref: Reactome:R-HSA-159728
has db xref: Reactome:R-HSA-159733
has db xref: Reactome:R-HSA-159771
has db xref: Reactome:R-HSA-159773
has db xref: Reactome:R-HSA-159796
has db xref: Reactome:R-HSA-159868
has db xref: Reactome:R-HSA-1602458
has db xref: Reactome:R-HSA-1602466
has db xref: Reactome:R-HSA-1602473
has db xref: Reactome:R-HSA-1602484
has db xref: Reactome:R-HSA-1602488
has db xref: Reactome:R-HSA-1604359
has db xref: Reactome:R-HSA-1604360
has db xref: Reactome:R-HSA-1604368
has db xref: Reactome:R-HSA-1604690
has db xref: Reactome:R-HSA-1604712
has db xref: Reactome:R-HSA-1604722
has db xref: Reactome:R-HSA-1604731
has db xref: Reactome:R-HSA-1604732
has db xref: Reactome:R-HSA-1604741
has db xref: Reactome:R-HSA-1604752
has db xref: Reactome:R-HSA-1604763
has db xref: Reactome:R-HSA-163798
has db xref: Reactome:R-HSA-163843
has db xref: Reactome:R-HSA-1655842
has db xref: Reactome:R-HSA-166753
has db xref: Reactome:R-HSA-166792
has db xref: Reactome:R-HSA-166817
has db xref: Reactome:R-HSA-170844
has db xref: Reactome:R-HSA-171288
has db xref: Reactome:R-HSA-173626
has db xref: Reactome:R-HSA-173631
has db xref: Reactome:R-HSA-173680
has db xref: Reactome:R-HSA-173745
has db xref: Reactome:R-HSA-174551
has db xref: Reactome:R-HSA-1799329
has db xref: Reactome:R-HSA-183122

Activated thrombin (factor IIa) cleaves PAR3,4, activating them
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114697

Cleavage of NODAL proprotein
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1181152

Granzyme-B activates BID by cleavage
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139893

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140599

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140664

factor V -> factor Va + factor V activation peptide
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140696

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140700

factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140736

factor VII -> factor VIIa
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140769

factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140777

factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140823

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140840

thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140870

Activated protein C cleaves factor Va to factor Vi intermediate form
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-141026

Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-141040

E-cadherin degradation by MMP3, MMP7 and plasmin.
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1454843

Collagen type II degradation by MMP1,3,8,13,PRSS2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1474197

Elastin degradation by elastin-degrading extracellular proteinases
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1566962

Laminin-332 degradation by laminin-322 degrading extracellular proteinases
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1566979

Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1566981

factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158137

factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158164

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158300

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158311

factor XII -> factor XIIa
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158313

factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158333

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158419

crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158744

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158747

crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158750

fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158766

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158925

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158942

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158982

NID1 degradation by MMP1, 9, 12, ELANE
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592270

Autocatalytic activation of proMMP2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592278

Full activation of MMP1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592297

HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592314

Initial activation of proMMP1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592316

Activation of proMMP7 by MMP3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592362

Initial activation of proMMP3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592371

Activation of proMMP8
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592398

Initial activation of proMMP9 by MMPs
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592436

Furin cleaves pro-prothrombin to prothrombin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159728

Furin cleaves pro-factor X to factor X
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159733

Furin cleaves pro-protein C to protein C
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159771

Furin cleaves pro-protein S to protein S
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159773

Furin cleaves pro-factor IX to factor IX
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159796

Furin cleaves pro-factor VII to factor VII
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159868

Activation of proMMP10
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602458

Activation of MT-MMPs by FURIN
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602466

Autocatalytic activation of MMP1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602473

Activation of proMMP11 by FURIN
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602484

Initial activation of proMMP13 by plasmin and trypsin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602488

Initial activation of proMMP2 by MMP1, 7
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604359

Initial activation of proMMP2 by MMP14
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604360

Autocatalytic activation of bound proMMP2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604368

Activation of MMP9 intermediate form by MMPs
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604690

Initial activation of proMMP7 by trypsin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604712

Activation of proMMP9 by proteases
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604722

Autocatalytic activation of MMP3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604731

Autocatalytic activation of proMMP13
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604732

Initial activation of proMMP13 by MMP14 (MT1-MMP)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604741

Initial activation of proMMP13 by MMP3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604752

Autocatalytic activation of MMP7
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1604763

Furin cleaves pro-protein Z to protein Z
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163798

Furin cleaves pro-GAS6 to GAS6
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163843

S1P hydrolyzes SREBP1A,1C,2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1655842

Conversion of C4 into C4a and C4b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166753

Conversion of C2 into C2a and C2b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166792

Cleavage of C3 by C3 convertases
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166817

Latent TGF-beta-1 is cleaved by FURIN
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170844

Cleavage of the viral Env gp160 precursor polyprotein
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-171288

Activation of C1r
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173626

Activation of C1s
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173631

Activation of C5
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173680

Factor D cleaves C3(H2O)-bound Factor B
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173745

Formation of alternative pathway C5 convertase
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174551

Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1799329

Factor D cleaves C3b-bound Factor B
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183122

C3(H2O):Factor Bb cleaves C3 to C3b and C3a
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183130

PDGF-AA clevage by Furin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-186785

Part of pro-beta-NGF is processed to mature beta-NGF
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187020

NOTCH precursor cleaved to form mature NOTCH
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912369

Fringe-modified Pre-NOTCH is cleaved by FURIN
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912372

Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022411

Fibrillin C-terminal processing
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2129357

Collagen type XVIII endostatin release
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2168923

Collagen type XVII ectodomain shedding
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2168960

Collagen type XXIII ectodomain shedding
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2172405

Cleavage of collagen VII NC2 region by BMP1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2214330

Endostatin degradation by cathepsins
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2471621

Collagen type XXV ectomain shedding
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2471842

Collagen type VIII degradation by ELANE
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2482180

Fibrillin-1 degradation by MMP3, CTSK, CTSL2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514772

Fibrillin-1 degradation by ELANE
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514823

HSPG2 (perlecan) degradation by MMP13, CTSS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534160

E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534206

E-cadherin degradation by caspase-3 and calpain-1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534260

Corticotropin cleavage from POMC
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265301

Factor I cleaves iC3b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3266557

Fibronectin degradation by CTSG
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3785684

Fibronectin degradation by ADAM8
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3788061

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381135

Thrombin proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381446

Plasmin proteolyzes IGF:IGFBP-3:ALS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381461

Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381466

HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3814820

Cathepsin G proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381500

PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381798

Extracellular processing of novel PDGFs
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-382061

MMP2,9 cleave EPHB
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928657

Signal peptidase hydrolyzes preproGLP-1 to proGLP-1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-400459

PCSK1 hydrolyzes proGIP to GIP
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-400492

Signal peptidase hydrolyzes preproGIP to proGIP
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-400496

PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-422021

Cleavage of the signal peptide of Preproghrelin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-422051

Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5210912

Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5210935

CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5578783

Activated protein C cleaves Factor Va intermediate form for Factor Va
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5591040

Activated protein C cleaves factor VIIIa
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607002

APEH hydrolyses NAc-Ser-protein
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5691512

HPN heterodimer cleaves pro-MST1 to form MST1 dimer
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800198

HPN heterodimer cleaves pro-HGF to form HGF dimer
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800200

HGFAC cleaves pro-HGF to form HGF dimer
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800299

PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801687

Furin cleaves pro-BGLAP to BGLAP
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807224

ST14 hydrolyzes and activates KLK5
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849826

KLK5 cleaves and activates CELA2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849857

KLK5 cleaves and activates KLK8
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8850831

Thrombin, ELANE cleave C5
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852716

HTRA1 hydrolyzes ACAN (Aggrecan)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855825

PDGF-BB clevage by Furin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865275

PDGF-AB clevage by Furin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865276

MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874145

MBTPS1 (S1P) cleaves CREB3L4
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874186

MBTPS1 (S1P) cleaves CREB3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874204

MBTPS1 (S1P) cleaves CREB3L2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874205

MBTPS1 (S1P) cleaves CREB3L3
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874206

MBTPS1 (S1P) cleaves CREB3L1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874212

PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023178

PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023196

DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023626

DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023627

DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023632

DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023633

TYSND1 cleaves PHYH
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033490

TYSND1 cleaves AGPS
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033506

TYSND1 cleaves ACOX1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033515

TYSND1 cleaves TYSND1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033520

TYSND1 cleaves SCP2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033524

TYSND1 cleaves ACAA1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033529

TYSND1 cleaves HSD17B4
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033530

Cleavage of factor XII variant by activated thrombin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9653249

Cleavage of FXII variant by KLKB1
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9655046

FURIN cleaves ADAM17
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9662786

F8 variant is not cleaved by thrombin
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9666383

Hyperactivation of factor X by FVIIIa:FIXa R384L
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9668253

FVIIIa variant:FIXa does not convert FX to the active FXa
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9668365

FIXa variant:FVIIIa does not convert FX to the active FXa
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9670874

FIX(29-461) variant is not activated (factor XIa catalyst)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673223

Cleavage of S protein into S1:S2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686710

TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686731

Cleavage of S protein into S1:S2
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694287

TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694661

Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698988

FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9699007

Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708859

ELANE cleaves GSDMD
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9710106

GZMB cleaves GSDME
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9710263

Factor I inactivates plasma Factor H-bound C3b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-976743

FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9769949

S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770187

Factor I inactivates Factor H-boundC3b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977371

Factor I inactivates MCP/CR1-bound C4b/C3b
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977615

Nascent F signal peptide is cleaved at ER membrane
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9829030

F0 is cleaved, releasing F1, F2, F(110-136)
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9829200

Nascent sG localizes to ER lumen, gets glycosylated
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9830805

Nascent G signal peptide is cleaved at ER membrane
type: Axiom
annotated source: GO_0004252
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9830882

GO_0004298
has db xref: Reactome:R-HSA-9818574
has db xref: Reactome:R-HSA-9818577

TASP1 cleaves KMT2A
type: Axiom
annotated source: GO_0004298
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9818574

TASP1 cleaves KMT2B
type: Axiom
annotated source: GO_0004298
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9818577

GO_0004300
has db xref: Reactome:R-HSA-70830
has db xref: Reactome:R-HSA-70870
has db xref: Reactome:R-HSA-77256
has db xref: Reactome:R-HSA-77277
has db xref: Reactome:R-HSA-77301
has db xref: Reactome:R-HSA-77314
has db xref: Reactome:R-HSA-77325
has db xref: Reactome:R-HSA-77333
has db xref: Reactome:R-HSA-77344

tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70830

ECHS1 hydrates methacrylyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70870

2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77256

trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77277

trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77301

Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77314

trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77325

trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77333

trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA
type: Axiom
annotated source: GO_0004300
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77344

GO_0004301
has db xref: Reactome:R-HSA-2161961
has db xref: Reactome:R-HSA-9018862
has db xref: Reactome:R-HSA-9018877
has db xref: Reactome:R-HSA-9020252
has db xref: Reactome:R-HSA-9020253
has db xref: Reactome:R-HSA-9020257
has db xref: Reactome:R-HSA-9020258
has db xref: Reactome:R-HSA-9020270
has db xref: Reactome:R-HSA-9024890
has db xref: Reactome:R-HSA-9024973
has db xref: Reactome:R-HSA-9024993
has db xref: Reactome:R-HSA-9025998
has db xref: Reactome:R-HSA-9026000
has db xref: Reactome:R-HSA-9026008

EET(1) is hydrolysed to DHET(1) by EPHX2
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161961

LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018862

LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018877

LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020252

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020253

LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020257

LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020258

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9020270

LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024890

Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024973

EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024993

Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9025998

Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026000

Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA
type: Axiom
annotated source: GO_0004301
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026008

GO_0004303
has db xref: Reactome:R-HSA-5693390
has db xref: Reactome:R-HSA-5696822
has db xref: Reactome:R-HSA-6810594
has db xref: Reactome:R-HSA-804969
has db xref: Reactome:R-HSA-8862137

HSD17B11 dehydrogenates EST17b to E1
type: Axiom
annotated source: GO_0004303
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693390

AKR1B15 reduces EST17b to E1
type: Axiom
annotated source: GO_0004303
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696822

HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)
type: Axiom
annotated source: GO_0004303
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6810594

HSD17B1 hydrogenates E1 to EST17b
type: Axiom
annotated source: GO_0004303
annotated property: hasDbXref
annotated target: Reactome:R-HSA-804969

HSD17B2 oxidises estradiol (E2) to estrone (E1)
type: Axiom
annotated source: GO_0004303
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8862137

GO_0004304
has db xref: Reactome:R-HSA-176664

estrone + PAPS => estrone 3-sulfate + PAP
type: Axiom
annotated source: GO_0004304
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176664

GO_0004305
has db xref: Reactome:R-HSA-1483222

ETA is phosphorylated to PETA by CHK/ETNK
type: Axiom
annotated source: GO_0004305
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483222

GO_0004306
has db xref: Reactome:R-HSA-1483190

PETA and CTP are condensed to CDP-ETA by PCY2
type: Axiom
annotated source: GO_0004306
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483190

GO_0004307
has db xref: Reactome:R-HSA-1482962

CDP-ETA and DAG are converted to PE by CEPT1/EPT1
type: Axiom
annotated source: GO_0004307
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482962

GO_0004308
has db xref: Reactome:R-HSA-1605723
has db xref: Reactome:R-HSA-1605724
has db xref: Reactome:R-HSA-1605768
has db xref: Reactome:R-HSA-168870
has db xref: Reactome:R-HSA-4084994
has db xref: Reactome:R-HSA-4084999
has db xref: Reactome:R-HSA-4085029
has db xref: Reactome:R-HSA-4341669
has db xref: Reactome:R-HSA-9638120

NEU2 cleaves GM3 to form LacCer (cytosol)
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605723

NEU1,4 hydrolyze PSAP(195-273):GM3:PE
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605724

NEU3 cleaves GM3 to form LacCer (plasma membrane)
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605768

Neuraminidase enzymatic release from sialic acid
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168870

NEU3 hydrolyzes Neu5Ac from glycoconjugates
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4084994

NEU1 hydrolyses Neu5Ac from glycoconjugates
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4084999

NEU2 hydrolyzes Neu5Ac from glycoconjugates
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4085029

Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4341669

NEU4 hydrolyses Neu5Ac from glycoconjugates
type: Axiom
annotated source: GO_0004308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638120

GO_0004310
has db xref: Reactome:R-HSA-191402
has db xref: Reactome:R-HSA-191405

Reduction of presqualene diphosphate to form squalene
type: Axiom
annotated source: GO_0004310
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191402

Two FPP molecules dimerize to form presqualene diphosphate
type: Axiom
annotated source: GO_0004310
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191405

GO_0004312
has db xref: Reactome:R-HSA-75872

acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
type: Axiom
annotated source: GO_0004312
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75872

GO_0004314
has db xref: Reactome:R-HSA-8933547

MCAT transfers Mal from Mal-CoA to NDUFAB1
type: Axiom
annotated source: GO_0004314
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8933547

GO_0004316
has db xref: Reactome:R-HSA-8862152

2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP
type: Axiom
annotated source: GO_0004316
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8862152

GO_0004322
has db xref: Reactome:R-HSA-1562603
has db xref: Reactome:R-HSA-1562604
has db xref: Reactome:R-HSA-1562626
has db xref: Reactome:R-HSA-5621402
has db xref: Reactome:R-HSA-5691107
has db xref: Reactome:R-HSA-917891
has db xref: Reactome:R-HSA-917933

BfrB stores iron
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1562603

BfrA stores iron
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1562604

Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1562626

Defective CP does not oxidise Fe2+ to Fe3+
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621402

FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5691107

SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-917891

SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+
type: Axiom
annotated source: GO_0004322
annotated property: hasDbXref
annotated target: Reactome:R-HSA-917933

GO_0004325
has db xref: Reactome:R-HSA-189465

FECH binds Fe2+ to PRIN9 to form heme
type: Axiom
annotated source: GO_0004325
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189465

GO_0004326
has db xref: Reactome:R-HSA-197958
has db xref: Reactome:R-HSA-200681
has db xref: Reactome:R-HSA-200682

FPGS-2 transforms THF to THFPG
type: Axiom
annotated source: GO_0004326
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197958

FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
type: Axiom
annotated source: GO_0004326
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200681

Mitochondrial FPGS-1 transforms THF to THFPG
type: Axiom
annotated source: GO_0004326
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200682

GO_0004329
has db xref: Reactome:R-HSA-200711
has db xref: Reactome:R-HSA-5696839
has db xref: Reactome:R-HSA-6801456

MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG
type: Axiom
annotated source: GO_0004329
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200711

MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
type: Axiom
annotated source: GO_0004329
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696839

MTHFD1L transforms 10-formyl-THF to HCOOH and THF
type: Axiom
annotated source: GO_0004329
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801456

GO_0004331
has db xref: Reactome:R-HSA-5628905
has db xref: Reactome:R-HSA-70262

TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate
type: Axiom
annotated source: GO_0004331
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5628905

Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
type: Axiom
annotated source: GO_0004331
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70262

GO_0004332
has db xref: Reactome:R-HSA-71495
has db xref: Reactome:R-HSA-71496

Aldolase tetramers convert GA3P and DHAP to F1,6PP
type: Axiom
annotated source: GO_0004332
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71495

D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
type: Axiom
annotated source: GO_0004332
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71496

GO_0004333
has db xref: Reactome:R-HSA-451033
has db xref: Reactome:R-HSA-70982

(S)-Malate <=> Fumarate + H2O
type: Axiom
annotated source: GO_0004333
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451033

Fumarate + H2O <=> (S)-Malate
type: Axiom
annotated source: GO_0004333
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70982

GO_0004334
has db xref: Reactome:R-HSA-71181

fumarylacetoacetate => fumarate + acetoacetate
type: Axiom
annotated source: GO_0004334
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71181

GO_0004335
has db xref: Reactome:R-HSA-5610026
has db xref: Reactome:R-HSA-70355

Defective GALK1 does not phosphorylate Gal
type: Axiom
annotated source: GO_0004335
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610026

GALK1 phosphorylates Gal to Gal1P
type: Axiom
annotated source: GO_0004335
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70355

GO_0004336
has db xref: Reactome:R-HSA-1606564

GALC hydrolyzes GalCer
type: Axiom
annotated source: GO_0004336
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606564

GO_0004337
has db xref: Reactome:R-HSA-191303
has db xref: Reactome:R-HSA-8870469
has db xref: Reactome:R-HSA-9717830

FDPS dimer transfers IPPP to GPP
type: Axiom
annotated source: GO_0004337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191303

RGGT geranylgeranylates RAB proteins
type: Axiom
annotated source: GO_0004337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8870469

GGPS1 hexamer transfers IPPP to GPP
type: Axiom
annotated source: GO_0004337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717830

GO_0004340
has db xref: Reactome:R-HSA-5621888
has db xref: Reactome:R-HSA-5621918
has db xref: Reactome:R-HSA-70420

Defective HK1 does not phosphorylate Glc to form G6P
type: Axiom
annotated source: GO_0004340
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621888

Defective GCK does not phosphorylate Glc to form G6P
type: Axiom
annotated source: GO_0004340
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621918

HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
type: Axiom
annotated source: GO_0004340
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70420

GO_0004342
has db xref: Reactome:R-HSA-6799604

GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P
type: Axiom
annotated source: GO_0004342
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799604

GO_0004343
has db xref: Reactome:R-HSA-449734

Acetylation of glucosamine 6-phosphate to GlcNAc6P
type: Axiom
annotated source: GO_0004343
annotated property: hasDbXref
annotated target: Reactome:R-HSA-449734

GO_0004345
has db xref: Reactome:R-HSA-70377

alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+
type: Axiom
annotated source: GO_0004345
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70377

GO_0004346
has db xref: Reactome:R-HSA-3262512
has db xref: Reactome:R-HSA-3266566
has db xref: Reactome:R-HSA-3274540
has db xref: Reactome:R-HSA-3282876
has db xref: Reactome:R-HSA-71825

G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)
type: Axiom
annotated source: GO_0004346
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3262512

G6PC2 hydrolyzes G6P to form Glc and Pi (islet)
type: Axiom
annotated source: GO_0004346
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3266566

Defective G6PC does not hydrolyze glucose 6-phosphate
type: Axiom
annotated source: GO_0004346
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3274540

Defective G6PC3 does not hydrolyze glucose 6-phosphate
type: Axiom
annotated source: GO_0004346
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3282876

G6PC hydrolyzes G6P to Glc and Pi (liver)
type: Axiom
annotated source: GO_0004346
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71825

GO_0004347
has db xref: Reactome:R-HSA-70471
has db xref: Reactome:R-HSA-70475

alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
type: Axiom
annotated source: GO_0004347
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70471

GPI dimer isomerizes Fru(6)P to G6P
type: Axiom
annotated source: GO_0004347
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70475

GO_0004348
has db xref: Reactome:R-HSA-1605591
has db xref: Reactome:R-HSA-1861788
has db xref: Reactome:R-HSA-1861789

GBA1:SAPC hydrolyzes GlcCer
type: Axiom
annotated source: GO_0004348
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605591

GBA2 hydrolyzes GlcCer (plasma membrane)
type: Axiom
annotated source: GO_0004348
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1861788

GBA3 hydrolyzes GlcCer (cytosol)
type: Axiom
annotated source: GO_0004348
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1861789

GO_0004351
has db xref: Reactome:R-HSA-888572
has db xref: Reactome:R-HSA-888577

PXLP-K405-GAD1 decarboxylates L-Glu to form GABA
type: Axiom
annotated source: GO_0004351
annotated property: hasDbXref
annotated target: Reactome:R-HSA-888572

Synthesis of GABA by GAD2
type: Axiom
annotated source: GO_0004351
annotated property: hasDbXref
annotated target: Reactome:R-HSA-888577

GO_0004353
has db xref: Reactome:R-HSA-70589
has db xref: Reactome:R-HSA-70600

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]
type: Axiom
annotated source: GO_0004353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70589

glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]
type: Axiom
annotated source: GO_0004353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70600

GO_0004356
has db xref: Reactome:R-HSA-70606

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
type: Axiom
annotated source: GO_0004356
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70606

GO_0004357
has db xref: Reactome:R-HSA-174367
has db xref: Reactome:R-HSA-5602892

GCL ligates L-Glu to L-Cys
type: Axiom
annotated source: GO_0004357
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174367

Defective GCLC does not ligate L-Glu to L-Cys
type: Axiom
annotated source: GO_0004357
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602892

GO_0004359
has db xref: Reactome:R-HSA-70609

glutamine + H2O => glutamate + NH4+ [GLS]
type: Axiom
annotated source: GO_0004359
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70609

GO_0004360
has db xref: Reactome:R-HSA-4085027
has db xref: Reactome:R-HSA-449715

Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P
type: Axiom
annotated source: GO_0004360
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4085027

GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P
type: Axiom
annotated source: GO_0004360
annotated property: hasDbXref
annotated target: Reactome:R-HSA-449715

GO_0004361
has db xref: Reactome:R-HSA-71046

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2
type: Axiom
annotated source: GO_0004361
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71046

GO_0004362
has db xref: Reactome:R-HSA-3323079
has db xref: Reactome:R-HSA-71682

GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
type: Axiom
annotated source: GO_0004362
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3323079

glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
type: Axiom
annotated source: GO_0004362
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71682

GO_0004363
has db xref: Reactome:R-HSA-174394
has db xref: Reactome:R-HSA-5602901

GSS:Mg2+ dimer synthesizes GSH
type: Axiom
annotated source: GO_0004363
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174394

Defective GSS does not synthesize GSH
type: Axiom
annotated source: GO_0004363
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602901

GO_0004364
has db xref: Reactome:R-HSA-176054
has db xref: Reactome:R-HSA-176059
has db xref: Reactome:R-HSA-3301943
has db xref: Reactome:R-HSA-5423653
has db xref: Reactome:R-HSA-9026777
has db xref: Reactome:R-HSA-9026780
has db xref: Reactome:R-HSA-9026901
has db xref: Reactome:R-HSA-9026911
has db xref: Reactome:R-HSA-9748996
has db xref: Reactome:R-HSA-9753280

GST dimers conjugate GSH with cytosolic substrates
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176054

GST trimers transfer GS from GSH to luminal substrates
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176059

GSTK1 dimer transfers GS from GSH to CDNB
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3301943

MGST trimers transfer GS from GSH to AFXBO and AFNBO
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423653

GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026777

LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026780

GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026901

LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026911

GST dimers cleave AZA to 6MP
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748996

GSTs transfer GSH to NAPQI to form APAP-SG
type: Axiom
annotated source: GO_0004364
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753280

GO_0004365
has db xref: Reactome:R-HSA-70449
has db xref: Reactome:R-HSA-70482

D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
type: Axiom
annotated source: GO_0004365
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70449

GAPDH tetramers reduce 1,3BPG to GA3P
type: Axiom
annotated source: GO_0004365
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70482

GO_0004366
has db xref: Reactome:R-HSA-1482695
has db xref: Reactome:R-HSA-549112
has db xref: Reactome:R-HSA-75886

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
type: Axiom
annotated source: GO_0004366
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482695

G3P is acylated to 1-acyl LPA by AGPAT6
type: Axiom
annotated source: GO_0004366
annotated property: hasDbXref
annotated target: Reactome:R-HSA-549112

glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]
type: Axiom
annotated source: GO_0004366
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75886

GO_0004367
has db xref: Reactome:R-HSA-75889

DHAP is converted to G3P by GPD1/GPD1L
type: Axiom
annotated source: GO_0004367
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75889

GO_0004368
has db xref: Reactome:R-HSA-188467

Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)
type: Axiom
annotated source: GO_0004368
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188467

GO_0004370
has db xref: Reactome:R-HSA-75887

Conversion of Glycerol to Glycerol-3-phosphate
type: Axiom
annotated source: GO_0004370
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75887

GO_0004372
has db xref: Reactome:R-HSA-5694137

PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
type: Axiom
annotated source: GO_0004372
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694137

GO_0004373
has db xref: Reactome:R-HSA-3322001
has db xref: Reactome:R-HSA-3322009
has db xref: Reactome:R-HSA-3322041
has db xref: Reactome:R-HSA-3828061
has db xref: Reactome:R-HSA-3858506

GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
type: Axiom
annotated source: GO_0004373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322001

GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2
type: Axiom
annotated source: GO_0004373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322009

Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
type: Axiom
annotated source: GO_0004373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322041

Defective GYS1 does not transfer glucose to growing glycogen chains
type: Axiom
annotated source: GO_0004373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3828061

Defective GYS2 does not transfer glucose to growing glycogen chains
type: Axiom
annotated source: GO_0004373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3858506

GO_0004375
has db xref: Reactome:R-HSA-5693967

PXLP-K754-GLDC dimer decarboxylates Gly
type: Axiom
annotated source: GO_0004375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693967

GO_0004376
has db xref: Reactome:R-HSA-162821
has db xref: Reactome:R-HSA-162873

Axiom
annotated source: GO_0004376
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162821
label: mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate

(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
type: Axiom
annotated source: GO_0004376
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162873

GO_0004379
has db xref: Reactome:R-HSA-184392
has db xref: Reactome:R-HSA-2534087

N-myristoylation of GAG polyprotein by NMT2
type: Axiom
annotated source: GO_0004379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-184392

NMT1/2 transfer MYS to GNAT1
type: Axiom
annotated source: GO_0004379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534087

GO_0004380
has db xref: Reactome:R-HSA-9033959
has db xref: Reactome:R-HSA-9034042

ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC
type: Axiom
annotated source: GO_0004380
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033959

sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec
type: Axiom
annotated source: GO_0004380
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9034042

GO_0004381
has db xref: Reactome:R-HSA-9033961
has db xref: Reactome:R-HSA-9034053

ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC
type: Axiom
annotated source: GO_0004381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033961

sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen
type: Axiom
annotated source: GO_0004381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9034053

GO_0004383
has db xref: Reactome:R-HSA-392152
has db xref: Reactome:R-HSA-74885

Soluble guanylate cyclase converts GTP to cGMP
type: Axiom
annotated source: GO_0004383
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392152

GUCYs converts GTP to cGMP
type: Axiom
annotated source: GO_0004383
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74885

GO_0004385
has db xref: Reactome:R-HSA-110133
has db xref: Reactome:R-HSA-73788
has db xref: Reactome:R-HSA-9748949
has db xref: Reactome:R-HSA-9748963

(d)GDP + ADP <=> (d)GMP + ATP (GUK1)
type: Axiom
annotated source: GO_0004385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110133

(d)GMP + ATP <=> (d)GDP + ADP (GUK1)
type: Axiom
annotated source: GO_0004385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73788

GUK1 phosphorylates 6TGMP to 6TGDP
type: Axiom
annotated source: GO_0004385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748949

GUK1 phosphorylates 6TdGMP to 6TdGDP
type: Axiom
annotated source: GO_0004385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748963

GO_0004386
has db xref: Reactome:R-HSA-169461
has db xref: Reactome:R-HSA-169468
has db xref: Reactome:R-HSA-5686410
has db xref: Reactome:R-HSA-5690996

MCM8 mediated fork unwinding
type: Axiom
annotated source: GO_0004386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169461

MCM2-7 mediated fork unwinding
type: Axiom
annotated source: GO_0004386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169468

BLM mediates dissolution of double Holliday junction
type: Axiom
annotated source: GO_0004386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686410

ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
type: Axiom
annotated source: GO_0004386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690996

GO_0004392
has db xref: Reactome:R-HSA-189398

HMOX1 dimer, HMOX2 cleave heme
type: Axiom
annotated source: GO_0004392
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189398

GO_0004394
has db xref: Reactome:R-HSA-2076508

HS2ST1 sulfates IdoA at C2 in heparan sulfate
type: Axiom
annotated source: GO_0004394
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2076508

GO_0004397
has db xref: Reactome:R-HSA-70899

histidine => urocanate + NH4+
type: Axiom
annotated source: GO_0004397
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70899

GO_0004398
has db xref: Reactome:R-HSA-977301

Histidine is decarboxylated to histamine
type: Axiom
annotated source: GO_0004398
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977301

GO_0004402
has db xref: Reactome:R-HSA-3301237
has db xref: Reactome:R-HSA-3301345
has db xref: Reactome:R-HSA-3318413
has db xref: Reactome:R-HSA-3318415
has db xref: Reactome:R-HSA-3318486
has db xref: Reactome:R-HSA-3321805
has db xref: Reactome:R-HSA-3321883
has db xref: Reactome:R-HSA-3321975
has db xref: Reactome:R-HSA-3451147
has db xref: Reactome:R-HSA-3662318
has db xref: Reactome:R-HSA-3662335
has db xref: Reactome:R-HSA-3697008
has db xref: Reactome:R-HSA-3697920
has db xref: Reactome:R-HSA-5144542
has db xref: Reactome:R-HSA-5250938

KAT2 complexes acetylate histone H3
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3301237

Elongator complex acetylates replicative histone H3, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3301345

KAT7-containing ING4/5 complexes acetylate Me3K-histone H3
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3318413

ATF2 acetylates histone H2B, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3318415

KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3318486

NSL acetylates histone H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3321805

MSL acetylates histone H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3321883

NuA4 complex acetylates histone H2A, HIST1H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3321975

KAT5 HAT complex acetylates TCF4 gene at histone H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3451147

Type B histone acetlytransferase complex acetylates histone H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3662318

EP300 acetylates histone H2A, H2B, H3, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3662335

CREBBP acetylates histone H2B, H3, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3697008

CLOCK acetylates lysine-10 of histone H3, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3697920

CLOCK acetylates lysine-15 of histone H3, H4
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5144542

B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
type: Axiom
annotated source: GO_0004402
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250938

GO_0004407
has db xref: Reactome:R-HSA-2545203
has db xref: Reactome:R-HSA-2545253
has db xref: Reactome:R-HSA-3769447
has db xref: Reactome:R-HSA-3777129
has db xref: Reactome:R-HSA-3782637
has db xref: Reactome:R-HSA-3782655
has db xref: Reactome:R-HSA-427514
has db xref: Reactome:R-HSA-433672
has db xref: Reactome:R-HSA-6805650

Deacetylation of cleaved cohesin
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2545203

Deacetylation of cohesin
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2545253

HDAC1:2-containing complex deacetylate histones
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3769447

HDAC3 containing complexes deacetylate histone
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3777129

HDAC8 deacetylates histones
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3782637

HDAC10 deacetylates histone
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3782655

eNoSC deacetylates histone H3
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427514

NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-433672

MTA2-NuRD complex deacetylates TP53
type: Axiom
annotated source: GO_0004407
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805650

GO_0004411
has db xref: Reactome:R-HSA-71164

homogentisate + O2 => maleylacetoacetate
type: Axiom
annotated source: GO_0004411
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71164

GO_0004415
has db xref: Reactome:R-HSA-1793209
has db xref: Reactome:R-HSA-2160874
has db xref: Reactome:R-HSA-2160892
has db xref: Reactome:R-HSA-2318585
has db xref: Reactome:R-HSA-5693356
has db xref: Reactome:R-HSA-9036077

HYAL1 hydrolyses Chondroitin chains
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1793209

HYAL1 hydrolyses (HA)50
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2160874

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2160892

Defective HYAL1 does not hydrolyse Chondroitin chains
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2318585

CEMIP hydrolyses HA
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693356

Defective HYAL1 does not hydrolyse (HA)50
type: Axiom
annotated source: GO_0004415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036077

GO_0004416
has db xref: Reactome:R-HSA-6783221

HAGH hydrolyses (R)-S-LGSH to GSH and LACT
type: Axiom
annotated source: GO_0004416
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6783221

GO_0004418
has db xref: Reactome:R-HSA-189406

4 PBGs bind to form HMB
type: Axiom
annotated source: GO_0004418
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189406

GO_0004419
has db xref: Reactome:R-HSA-6788597
has db xref: Reactome:R-HSA-74180

HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA
type: Axiom
annotated source: GO_0004419
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6788597

HMG CoA => acetoacetic acid + acetyl CoA
type: Axiom
annotated source: GO_0004419
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74180

GO_0004420
has db xref: Reactome:R-HSA-191352

HMGCR dimer reduces bHMG-CoA to MVA
type: Axiom
annotated source: GO_0004420
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191352

GO_0004421
has db xref: Reactome:R-HSA-191323
has db xref: Reactome:R-HSA-73918

HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA
type: Axiom
annotated source: GO_0004421
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191323

acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
type: Axiom
annotated source: GO_0004421
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73918

GO_0004423
has db xref: Reactome:R-HSA-1678650
has db xref: Reactome:R-HSA-1793182
has db xref: Reactome:R-HSA-2262743
has db xref: Reactome:R-HSA-9036046

IDS hydrolyses Heparan sulfate chain(5)
type: Axiom
annotated source: GO_0004423
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678650

IDS hydrolyses dermatan sulfate (Chebi:63517 chain)
type: Axiom
annotated source: GO_0004423
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1793182

Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)
type: Axiom
annotated source: GO_0004423
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2262743

Defective IDS does not hydrolyse Heparan sulfate chain(5)
type: Axiom
annotated source: GO_0004423
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036046

GO_0004427
has db xref: Reactome:R-HSA-449937
has db xref: Reactome:R-HSA-6788912
has db xref: Reactome:R-HSA-71732

pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
type: Axiom
annotated source: GO_0004427
annotated property: hasDbXref
annotated target: Reactome:R-HSA-449937

LHPP:Mg2+ dimer hydrolyses PPi
type: Axiom
annotated source: GO_0004427
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6788912

PPA1 hydrolyzes pyrophosphate to orthophosphate
type: Axiom
annotated source: GO_0004427
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71732

GO_0004430
has db xref: Reactome:R-HSA-1675780
has db xref: Reactome:R-HSA-1675813
has db xref: Reactome:R-HSA-1675883
has db xref: Reactome:R-HSA-1675974
has db xref: Reactome:R-HSA-1676185

PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
type: Axiom
annotated source: GO_0004430
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675780

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
type: Axiom
annotated source: GO_0004430
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675813

PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
type: Axiom
annotated source: GO_0004430
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675883

PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
type: Axiom
annotated source: GO_0004430
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675974

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
type: Axiom
annotated source: GO_0004430
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676185

GO_0004435
has db xref: Reactome:R-HSA-111879
has db xref: Reactome:R-HSA-167686
has db xref: Reactome:R-HSA-1855177
has db xref: Reactome:R-HSA-1855214
has db xref: Reactome:R-HSA-1855221
has db xref: Reactome:R-HSA-202407
has db xref: Reactome:R-HSA-2730847
has db xref: Reactome:R-HSA-5607735
has db xref: Reactome:R-HSA-622382
has db xref: Reactome:R-HSA-9032478
has db xref: Reactome:R-HSA-9717205

PIP2 hydrolysis
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111879

Active PLCG1 hydrolyses PIP2
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167686

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855177

PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855214

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855221

PLC-gamma1 hydrolyses PIP2
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202407

Hydrolysis of PIP2 by PLCG
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730847

p-Y753,Y759-PLCG2 hydrolyses PIP2
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607735

PIP2 hydrolysis
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-622382

EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032478

GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG
type: Axiom
annotated source: GO_0004435
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717205

GO_0004438
has db xref: Reactome:R-HSA-1675795
has db xref: Reactome:R-HSA-1675994
has db xref: Reactome:R-HSA-1676114
has db xref: Reactome:R-HSA-1676141
has db xref: Reactome:R-HSA-6809325
has db xref: Reactome:R-HSA-6809720
has db xref: Reactome:R-HSA-6809777
has db xref: Reactome:R-HSA-6809975

PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675795

PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675994

PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676114

PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676141

PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809325

PI3P is dephosphorylated to PI by MTM1:MTMR12
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809720

PI3P is dephosphorylated to PI by MTMR2:SBF1
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809777

PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane
type: Axiom
annotated source: GO_0004438
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6809975

GO_0004439
has db xref: Reactome:R-HSA-1675824
has db xref: Reactome:R-HSA-1676177
has db xref: Reactome:R-HSA-8868648

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
type: Axiom
annotated source: GO_0004439
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1675824

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
type: Axiom
annotated source: GO_0004439
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1676177

SYNJ hydrolyze PI(4,5)P2 to PI(4)P
type: Axiom
annotated source: GO_0004439
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868648

GO_0004441
has db xref: Reactome:R-HSA-1855208

I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
type: Axiom
annotated source: GO_0004441
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855208

GO_0004449
has db xref: Reactome:R-HSA-70967

isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]
type: Axiom
annotated source: GO_0004449
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70967

GO_0004450
has db xref: Reactome:R-HSA-389540
has db xref: Reactome:R-HSA-389550
has db xref: Reactome:R-HSA-450984

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Axiom
annotated source: GO_0004450
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389540

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Axiom
annotated source: GO_0004450
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389550

isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]
type: Axiom
annotated source: GO_0004450
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450984

GO_0004452
has db xref: Reactome:R-HSA-191382

Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate
type: Axiom
annotated source: GO_0004452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191382

GO_0004454
has db xref: Reactome:R-HSA-5656459
has db xref: Reactome:R-HSA-70333

Defective KHK does not phosphorylate beta-D-fructose
type: Axiom
annotated source: GO_0004454
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656459

KHK dimer phosphorylates Fru to Fru 1-P
type: Axiom
annotated source: GO_0004454
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70333

GO_0004459
has db xref: Reactome:R-HSA-6807826
has db xref: Reactome:R-HSA-70510
has db xref: Reactome:R-HSA-71849

LDHAL6B reduces PYR to LACT
type: Axiom
annotated source: GO_0004459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807826

LDH tetramer oxidises LACT to PYR
type: Axiom
annotated source: GO_0004459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70510

LDH tetramer reduces PYR to LACT
type: Axiom
annotated source: GO_0004459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71849

GO_0004461
has db xref: Reactome:R-HSA-5653878

B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac
type: Axiom
annotated source: GO_0004461
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653878

GO_0004462
has db xref: Reactome:R-HSA-5694071

GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
type: Axiom
annotated source: GO_0004462
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694071

GO_0004463
has db xref: Reactome:R-HSA-266072

LTA4 is hydolysed to LTB4 by LTA4H
type: Axiom
annotated source: GO_0004463
annotated property: hasDbXref
annotated target: Reactome:R-HSA-266072

GO_0004464
has db xref: Reactome:R-HSA-266050

LTA4 is converted to LTC4 by LTC4S
type: Axiom
annotated source: GO_0004464
annotated property: hasDbXref
annotated target: Reactome:R-HSA-266050

GO_0004465
has db xref: Reactome:R-HSA-1482811
has db xref: Reactome:R-HSA-174757
has db xref: Reactome:R-HSA-2395768
has db xref: Reactome:R-HSA-6789310
has db xref: Reactome:R-HSA-8979996
has db xref: Reactome:R-HSA-8980228

DAG is hydrolyzed to 2-MAG by PNPLA2/3
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482811

chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174757

LPL hydrolyses TGs from mature CMs
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2395768

LIPs hydrolyse TG to DAG and RCOOH
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6789310

LIPs hydrolyze TG to DAG and LCFA
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8979996

LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA
type: Axiom
annotated source: GO_0004465
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8980228

GO_0004467
has db xref: Reactome:R-HSA-159425
has db xref: Reactome:R-HSA-192137
has db xref: Reactome:R-HSA-193401
has db xref: Reactome:R-HSA-193407
has db xref: Reactome:R-HSA-193424
has db xref: Reactome:R-HSA-193711
has db xref: Reactome:R-HSA-193727
has db xref: Reactome:R-HSA-193743
has db xref: Reactome:R-HSA-193766
has db xref: Reactome:R-HSA-201035
has db xref: Reactome:R-HSA-2046085
has db xref: Reactome:R-HSA-2046098
has db xref: Reactome:R-HSA-548843
has db xref: Reactome:R-HSA-5696004
has db xref: Reactome:R-HSA-9734535

Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159425

THCA is conjugated with Coenzyme A (SLC27A5 BACS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192137

THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193401

DHCA is conjugated with Coenzyme A (SLC27A5 BACS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193407

DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193424

3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193711

TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193727

3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193743

TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193766

ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201035

Activation of alpha-linolenic acid to alpha-linolenoyl-CoA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046085

Activation of linoleic acid to linoleoyl-CoA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046098

ACSL3,4 ligate CoA to AA to form AA-CoA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-548843

ACSF2 ligates CoA-SH to MCFA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696004

SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA
type: Axiom
annotated source: GO_0004467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9734535

GO_0004468
has db xref: Reactome:R-HSA-5618328
has db xref: Reactome:R-HSA-5693001

ATAT acetylates microtubules
type: Axiom
annotated source: GO_0004468
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5618328

NAT8,8B acetylate BACE1
type: Axiom
annotated source: GO_0004468
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693001

GO_0004471
has db xref: Reactome:R-HSA-9012268

ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
type: Axiom
annotated source: GO_0004471
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012268

GO_0004473
has db xref: Reactome:R-HSA-9012036
has db xref: Reactome:R-HSA-9012349

ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
type: Axiom
annotated source: GO_0004473
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012036

ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
type: Axiom
annotated source: GO_0004473
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012349

GO_0004475
has db xref: Reactome:R-HSA-446221

Mannose-1-phosphate converted to GDP-Mannose
type: Axiom
annotated source: GO_0004475
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446221

GO_0004476
has db xref: Reactome:R-HSA-3781832
has db xref: Reactome:R-HSA-532549

Defective MPI does not isomerize Fru6P to Man6P
type: Axiom
annotated source: GO_0004476
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3781832

MPI isomerises Fru6P to Man6P
type: Axiom
annotated source: GO_0004476
annotated property: hasDbXref
annotated target: Reactome:R-HSA-532549

GO_0004477
has db xref: Reactome:R-HSA-200661
has db xref: Reactome:R-HSA-200740
has db xref: Reactome:R-HSA-6801328

MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
type: Axiom
annotated source: GO_0004477
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200661

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
type: Axiom
annotated source: GO_0004477
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200740

MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
type: Axiom
annotated source: GO_0004477
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801328

GO_0004478
has db xref: Reactome:R-HSA-174391
has db xref: Reactome:R-HSA-5603087
has db xref: Reactome:R-HSA-5603114

MAT1A multimers transfer Ado from ATP to L-Met
type: Axiom
annotated source: GO_0004478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174391

Defective MAT1A does not transfer Ado from ATP to L-Met
type: Axiom
annotated source: GO_0004478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603087

MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met
type: Axiom
annotated source: GO_0004478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603114

GO_0004479
has db xref: Reactome:R-HSA-5389841

MTFMT formylates methionyl-tRNA
type: Axiom
annotated source: GO_0004479
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5389841

GO_0004482
has db xref: Reactome:R-HSA-77090
has db xref: Reactome:R-HSA-9684016
has db xref: Reactome:R-HSA-9684017
has db xref: Reactome:R-HSA-9684018
has db xref: Reactome:R-HSA-9694476
has db xref: Reactome:R-HSA-9694492
has db xref: Reactome:R-HSA-9694737
has db xref: Reactome:R-HSA-9830848

Methylation of GMP-cap by RNA Methyltransferase
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77090

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684016

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684017

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684018

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694476

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694492

nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694737

L protein acts as a cap N7 methyltransferase to modify RSV mRNAs
type: Axiom
annotated source: GO_0004482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9830848

GO_0004483
has db xref: Reactome:R-HSA-9684030
has db xref: Reactome:R-HSA-9684032
has db xref: Reactome:R-HSA-9684033
has db xref: Reactome:R-HSA-9694499
has db xref: Reactome:R-HSA-9694521
has db xref: Reactome:R-HSA-9694721
has db xref: Reactome:R-HSA-9834003

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684030

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684032

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9684033

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694499

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694521

nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694721

L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs
type: Axiom
annotated source: GO_0004483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9834003

GO_0004484
has db xref: Reactome:R-HSA-77081
has db xref: Reactome:R-HSA-77083
has db xref: Reactome:R-HSA-9815529

Formation of the CE:GMP intermediate complex
type: Axiom
annotated source: GO_0004484
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77081

Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
type: Axiom
annotated source: GO_0004484
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77083

nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs
type: Axiom
annotated source: GO_0004484
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9815529

GO_0004485
has db xref: Reactome:R-HSA-508308
has db xref: Reactome:R-HSA-70773

beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]
type: Axiom
annotated source: GO_0004485
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508308

beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]
type: Axiom
annotated source: GO_0004485
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70773

GO_0004486
has db xref: Reactome:R-HSA-200644
has db xref: Reactome:R-HSA-200718

5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
type: Axiom
annotated source: GO_0004486
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200644

MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG
type: Axiom
annotated source: GO_0004486
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200718

GO_0004487
has db xref: Reactome:R-HSA-6801462

MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF
type: Axiom
annotated source: GO_0004487
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801462

GO_0004489
has db xref: Reactome:R-HSA-200676

MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
type: Axiom
annotated source: GO_0004489
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200676

GO_0004490
has db xref: Reactome:R-HSA-70785

beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
type: Axiom
annotated source: GO_0004490
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70785

GO_0004491
has db xref: Reactome:R-HSA-70893

methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+
type: Axiom
annotated source: GO_0004491
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70893

GO_0004493
has db xref: Reactome:R-HSA-71020

D-methylmalonyl-CoA <=> L-methylmalonyl-CoA
type: Axiom
annotated source: GO_0004493
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71020

GO_0004494
has db xref: Reactome:R-HSA-3322971
has db xref: Reactome:R-HSA-71010

Defective MUT does not isomerise L-MM-CoA to SUCC-CoA
type: Axiom
annotated source: GO_0004494
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322971

MUT isomerises L-MM-CoA to SUCC-CoA
type: Axiom
annotated source: GO_0004494
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71010

GO_0004496
has db xref: Reactome:R-HSA-191380

Mevalonate is phosphorylated to mevalonate-5-phosphate
type: Axiom
annotated source: GO_0004496
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191380

GO_0004497
has db xref: Reactome:R-HSA-143468
has db xref: Reactome:R-HSA-156526
has db xref: Reactome:R-HSA-211882
has db xref: Reactome:R-HSA-211904
has db xref: Reactome:R-HSA-211910
has db xref: Reactome:R-HSA-211919
has db xref: Reactome:R-HSA-211924
has db xref: Reactome:R-HSA-211929
has db xref: Reactome:R-HSA-211948
has db xref: Reactome:R-HSA-211951
has db xref: Reactome:R-HSA-211959
has db xref: Reactome:R-HSA-211960
has db xref: Reactome:R-HSA-211962
has db xref: Reactome:R-HSA-211968
has db xref: Reactome:R-HSA-211988
has db xref: Reactome:R-HSA-211991
has db xref: Reactome:R-HSA-212004
has db xref: Reactome:R-HSA-212005
has db xref: Reactome:R-HSA-213175
has db xref: Reactome:R-HSA-215526
has db xref: Reactome:R-HSA-2161795
has db xref: Reactome:R-HSA-2161814
has db xref: Reactome:R-HSA-2161890
has db xref: Reactome:R-HSA-2161899
has db xref: Reactome:R-HSA-2161940
has db xref: Reactome:R-HSA-2162191
has db xref: Reactome:R-HSA-217258
has db xref: Reactome:R-HSA-5423647
has db xref: Reactome:R-HSA-5423664
has db xref: Reactome:R-HSA-5423672
has db xref: Reactome:R-HSA-5423678
has db xref: Reactome:R-HSA-5602242
has db xref: Reactome:R-HSA-5602272
has db xref: Reactome:R-HSA-5602295
has db xref: Reactome:R-HSA-5605147
has db xref: Reactome:R-HSA-5662662
has db xref: Reactome:R-HSA-5662692
has db xref: Reactome:R-HSA-5663050
has db xref: Reactome:R-HSA-6786239
has db xref: Reactome:R-HSA-76354
has db xref: Reactome:R-HSA-76373
has db xref: Reactome:R-HSA-76386
has db xref: Reactome:R-HSA-76397
has db xref: Reactome:R-HSA-76416
has db xref: Reactome:R-HSA-76426
has db xref: Reactome:R-HSA-76434
has db xref: Reactome:R-HSA-76456
has db xref: Reactome:R-HSA-76466
has db xref: Reactome:R-HSA-76472
has db xref: Reactome:R-HSA-76475
has db xref: Reactome:R-HSA-8865107
has db xref: Reactome:R-HSA-9018874
has db xref: Reactome:R-HSA-9027042
has db xref: Reactome:R-HSA-9027043
has db xref: Reactome:R-HSA-9027044
has db xref: Reactome:R-HSA-9027302
has db xref: Reactome:R-HSA-9027321
has db xref: Reactome:R-HSA-9037761
has db xref: Reactome:R-HSA-9749986
has db xref: Reactome:R-HSA-9750016
has db xref: Reactome:R-HSA-9753285
has db xref: Reactome:R-HSA-9756138
has db xref: Reactome:R-HSA-9756162
has db xref: Reactome:R-HSA-9756169
has db xref: Reactome:R-HSA-9756180

MEOS oxidizes ethanol to acetaldehyde
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-143468

CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156526

CYP3A7 can 6beta-hydroxylate testosterone
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211882

CYP4F12 18-hydroxylates ARA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211904

CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211910

CYP4F8 19-hydroxylates PGH2
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211919

CYP4B1 12-hydroxylates ARA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211924

CYP2C19 5-hydroxylates omeprazole
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211929

CYP3A4 can N-demethylate loperamide
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211948

CYP1B1 4-hydroxylates EST17b
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211951

CYP3A43 6b-hydroxylates TEST
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211959

CYP2U1 19-hydroxylates ARA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211960

CYP4F11 16-hydroxylates 3OH-PALM
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211962

CYP2W1 oxidises INDOL
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211968

CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211988

Cyclophosphamide is 4-hydroxylated by CYP2B6
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211991

CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212004

CYP2F1 dehydrogenates 3-methylindole
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212005

CYP3A4,5 oxidise AFB1 to AFXBO
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-213175

CYP4F3 20-hydroxylates LTB4
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-215526

Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161795

Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161814

Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161890

Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161899

Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161940

DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162191

FMO2:FAD:Mg2+ S-oxidises MTZ
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-217258

CYP2A13 oxidises AFM1 to AFM1E
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423647

CYP3A4,5 hydroxylates AFB1 to AFQ1
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423664

CYP1A2, 3A4 oxidise AFB1 to AFNBO
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423672

CYP1A2 hydroxylates AFB1 to AFM1
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5423678

Defective CYP2U1 does not omega-hydroxylate ARA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602242

Defective CYP4F22 does not 20-hydroxylate TrXA3
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602272

CYP4F22 20-hydroxylates TrXA3
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602295

Defective CYP1B1 does not 4-hydroxylate EST17b
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5605147

Tyrosinase oxidises tyrosine to dopaquinone
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5662662

Dopa is oxidized to dopaquinone by TYR
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5662692

DHI and DHICA polymerize forming eumelanin
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5663050

CYP4V2 omega-hydroxylates DHA to HDoHE
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786239

Vinyl chloride is oxidized to 2-Chloroethylene oxide
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76354

N-hydroxylation of 4-aminobiphenyl
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76373

CYP1A2 S-demethylates 6MMP
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76386

Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76397

Benzene is hydroxylated to phenol
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76416

N-atom dealkylation of caffeine
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76426

Dehalogenation of carbon tetrachloride to form a free radical
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76434

O-atom dealkylation of dextromethorphan
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76456

CYP4A11 12-hydroxylates DDCX
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76466

Ethylene is oxidized to Ethylene oxide by CYP1A1
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76472

Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76475

MICAL1 produces NADP+, H2O2
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865107

CYP monooxygenates EPA to 18(S)-HpEPE
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018874

CPY4 -oxidises 14(S)-HDHA to MaR-L1
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027042

CYPs hydroxylate DHA to 14(R)-HDHA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027043

CYP4 -oxidises 14(R)-HDHA to MaR-L2
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027044

CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027302

CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027321

CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9037761

CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9749986

CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9750016

CYP2E1 monooxygenates APAP to NAPQI
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753285

CYP3A4 monooxygenates ATVL to 2-OH-ATVL
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9756138

CYP3A4 monooxygenates ATV to 4-OH-ATV
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9756162

CYP3A4 monooxygenates ATV to 2-OH-ATV
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9756169

CYP3A4 monooxygenates ATVL to 4-OH-ATVL
type: Axiom
annotated source: GO_0004497
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9756180

GO_0004498
has db xref: Reactome:R-HSA-209868
has db xref: Reactome:R-HSA-5602186

CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
type: Axiom
annotated source: GO_0004498
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209868

Defective CYP27B1 does not hydroxylate CDL
type: Axiom
annotated source: GO_0004498
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602186

GO_0004499
has db xref: Reactome:R-HSA-139970
has db xref: Reactome:R-HSA-217255
has db xref: Reactome:R-HSA-5602966

FMO3:FAD N-oxidises TMA to TMAO
type: Axiom
annotated source: GO_0004499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139970

FMO1:FAD N-oxidises TAM
type: Axiom
annotated source: GO_0004499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-217255

Defective FMO3 does not N-oxidise TMA
type: Axiom
annotated source: GO_0004499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602966

GO_0004500
has db xref: Reactome:R-HSA-209891

Dopamine is oxidised to noradrenaline
type: Axiom
annotated source: GO_0004500
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209891

GO_0004502
has db xref: Reactome:R-HSA-71200

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
type: Axiom
annotated source: GO_0004502
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71200

GO_0004505
has db xref: Reactome:R-HSA-5649483
has db xref: Reactome:R-HSA-71118

Defective PAH does not hydroxylate L-Phe to L-Tyr
type: Axiom
annotated source: GO_0004505
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649483

PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
type: Axiom
annotated source: GO_0004505
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71118

GO_0004506
has db xref: Reactome:R-HSA-191299

Squalene is oxidized to its epoxide
type: Axiom
annotated source: GO_0004506
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191299

GO_0004507
has db xref: Reactome:R-HSA-193997
has db xref: Reactome:R-HSA-194017
has db xref: Reactome:R-HSA-5580292
has db xref: Reactome:R-HSA-5600598

CYP11B1 oxidises 11DCORT
type: Axiom
annotated source: GO_0004507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193997

CYP11B2 oxidises 11DCORST to CORST
type: Axiom
annotated source: GO_0004507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194017

Defective CYP11B1 does not oxidise 11DCORT
type: Axiom
annotated source: GO_0004507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5580292

Defective CYP11B2 does not oxidise 11DCORST
type: Axiom
annotated source: GO_0004507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5600598

GO_0004508
has db xref: Reactome:R-HSA-193068
has db xref: Reactome:R-HSA-193070
has db xref: Reactome:R-HSA-193072
has db xref: Reactome:R-HSA-193099
has db xref: Reactome:R-HSA-5601843
has db xref: Reactome:R-HSA-9035954
has db xref: Reactome:R-HSA-9035956

CYP17A1 17-hydroxylates PREG
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193068

CYP17A1 cleaves 17aHPREG to DHA
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193070

CYP17A1 17-hydroxylates P4 to 17aHPROG
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193072

CYP17A1 cleaves 17aHPROG to ANDST
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193099

Defective CYP17A1 does not 17-hydroxylate PREG
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601843

Defective CYP17A1 does not 17-hydroxylate P4
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035954

Defective CYP17A1 does not cleave 17aHPROG
type: Axiom
annotated source: GO_0004508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035956

GO_0004509
has db xref: Reactome:R-HSA-193964
has db xref: Reactome:R-HSA-193981
has db xref: Reactome:R-HSA-5601976

CYP21A2 21-hydroxylates PROG
type: Axiom
annotated source: GO_0004509
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193964

CYP21A2 oxidises 17HPROG
type: Axiom
annotated source: GO_0004509
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193981

Defective CYP21A2 does not 21-hydroxylate PROG
type: Axiom
annotated source: GO_0004509
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601976

GO_0004510
has db xref: Reactome:R-HSA-209828

Tryptophan is hydroxylated
type: Axiom
annotated source: GO_0004510
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209828

GO_0004511
has db xref: Reactome:R-HSA-209823

Tyrosine is hydroxylated to dopa
type: Axiom
annotated source: GO_0004511
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209823

GO_0004512
has db xref: Reactome:R-HSA-1855178

Glc6P is isomerised to I3P by ISYNA1 in the cytosol
type: Axiom
annotated source: GO_0004512
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855178

GO_0004514
has db xref: Reactome:R-HSA-197268

QPRT transfers PRIB to QUIN to form NAMN
type: Axiom
annotated source: GO_0004514
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197268

GO_0004515
has db xref: Reactome:R-HSA-197235
has db xref: Reactome:R-HSA-200474
has db xref: Reactome:R-HSA-200512

NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
type: Axiom
annotated source: GO_0004515
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197235

NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
type: Axiom
annotated source: GO_0004515
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200474

NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
type: Axiom
annotated source: GO_0004515
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200512

GO_0004516
has db xref: Reactome:R-HSA-197186

NAPRT1 dimer transfers PRIB to NCA to form NAMN
type: Axiom
annotated source: GO_0004516
annotated property: hasDbXref
annotated target: Reactome:R-HSA-197186

GO_0004517
has db xref: Reactome:R-HSA-202127
has db xref: Reactome:R-HSA-418436

eNOS synthesizes NO
type: Axiom
annotated source: GO_0004517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202127

Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
type: Axiom
annotated source: GO_0004517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418436

GO_0004519
has db xref: Reactome:R-HSA-5358512
has db xref: Reactome:R-HSA-5358518
has db xref: Reactome:R-HSA-5690990
has db xref: Reactome:R-HSA-5693533
has db xref: Reactome:R-HSA-72180

MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more
type: Axiom
annotated source: GO_0004519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358512

MLH1:PMS2 makes single strand incision near 1-2 base mismatch
type: Axiom
annotated source: GO_0004519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358518

5'- incision of DNA by ERCC1:ERCC4 in GG-NER
type: Axiom
annotated source: GO_0004519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690990

DCLRE1C (ARTEMIS) processes DNA DSB ends
type: Axiom
annotated source: GO_0004519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693533

Cleavage of mRNA at the 3'-end
type: Axiom
annotated source: GO_0004519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-72180

GO_0004520
has db xref: Reactome:R-HSA-110359
has db xref: Reactome:R-HSA-5686440
has db xref: Reactome:R-HSA-5686657
has db xref: Reactome:R-HSA-5687464
has db xref: Reactome:R-HSA-5690988
has db xref: Reactome:R-HSA-5693584
has db xref: Reactome:R-HSA-5693608
has db xref: Reactome:R-HSA-6782204
has db xref: Reactome:R-HSA-6782224
has db xref: Reactome:R-HSA-9023941

APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110359

MUS81:EME1,EME2 cleaves D-loop
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686440

ERCC1:XPF cleaves flaps generated by SSA
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686657

MRN and RBBP8 resect DNA DSBs in MMEJ
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687464

3'-incision of DNA by ERCC5 (XPG) in GG-NER
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690988

Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693584

Initial resection of double-strand break ends
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693608

5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782204

3' incision by ERCC5 (XPG) in TC-NER
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782224

MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11
type: Axiom
annotated source: GO_0004520
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023941

GO_0004521
has db xref: Reactome:R-HSA-425923
has db xref: Reactome:R-HSA-426520
has db xref: Reactome:R-HSA-5601887
has db xref: Reactome:R-HSA-5601910
has db xref: Reactome:R-HSA-6791223
has db xref: Reactome:R-HSA-6814555
has db xref: Reactome:R-HSA-9009936
has db xref: Reactome:R-HSA-9009941
has db xref: Reactome:R-HSA-9023909
has db xref: Reactome:R-HSA-9023912
has db xref: Reactome:R-HSA-927836
has db xref: Reactome:R-HSA-9708327
has db xref: Reactome:R-HSA-9708812

IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425923

Endonucleolytic RISC hydrolyzes target RNAs
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-426520

PLD6 dimer cleaves primary piRNA transcript to pre-piRNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601887

Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601910

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6791223

Integrator complex processes the 3' end of snRNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814555

RNASEL cleaves cellular ssRNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9009936

RNASEL cleaves viral ssRNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9009941

C3PO hydrolyzes cleaved passenger strand
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023909

AGO2 cleaves passenger strand of duplex siRNA
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023912

SMG6 hydrolyzes mRNA with premature termination codon
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-927836

ANG cleaves tRNA to yield tRNA halves
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708327

ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)
type: Axiom
annotated source: GO_0004521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708812

GO_0004523
has db xref: Reactome:R-HSA-164519
has db xref: Reactome:R-HSA-164528
has db xref: Reactome:R-HSA-173769
has db xref: Reactome:R-HSA-182795
has db xref: Reactome:R-HSA-182859

RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
type: Axiom
annotated source: GO_0004523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164519

RNase H-mediated cleavage of the template strand
type: Axiom
annotated source: GO_0004523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164528

RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
type: Axiom
annotated source: GO_0004523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173769

RNase H-mediated degradation of the template strand
type: Axiom
annotated source: GO_0004523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-182795

RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
type: Axiom
annotated source: GO_0004523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-182859

GO_0004525
has db xref: Reactome:R-HSA-203862
has db xref: Reactome:R-HSA-203893
has db xref: Reactome:R-HSA-426464
has db xref: Reactome:R-HSA-9708292
has db xref: Reactome:R-HSA-9708408
has db xref: Reactome:R-HSA-9820840

Dicer cleaves pre-miRNA to yield duplex miRNA
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203862

Microprocessor complex cleaves pri-miRNA to pre-miRNA
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203893

Dicer cleaves double-stranded RNA to yield double-stranded siRNA
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-426464

DICER1 cleaves tRNA
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708292

DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9708408

DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA
type: Axiom
annotated source: GO_0004525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9820840

GO_0004526
has db xref: Reactome:R-HSA-5696810

RNase P cleaves the 5' end of pre-tRNA
type: Axiom
annotated source: GO_0004526
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696810

GO_0004532
has db xref: Reactome:R-HSA-429961

DCPS scavenges the 7-methylguanosine cap of mRNA
type: Axiom
annotated source: GO_0004532
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429961

GO_0004534
has db xref: Reactome:R-HSA-429845

5' to 3' exoribonuclease hydrolyzes decapped mRNA
type: Axiom
annotated source: GO_0004534
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429845

GO_0004535
has db xref: Reactome:R-HSA-429955
has db xref: Reactome:R-HSA-429992
has db xref: Reactome:R-HSA-430021
has db xref: Reactome:R-HSA-9822311
has db xref: Reactome:R-HSA-9822335

CCR4-NOT complex deadenylates mRNA
type: Axiom
annotated source: GO_0004535
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429955

PARN deadenylates mRNA
type: Axiom
annotated source: GO_0004535
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429992

PAN2-PAN3 complex partially deadenylates mRNA
type: Axiom
annotated source: GO_0004535
annotated property: hasDbXref
annotated target: Reactome:R-HSA-430021

CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP
type: Axiom
annotated source: GO_0004535
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9822311

CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA
type: Axiom
annotated source: GO_0004535
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9822335

GO_0004536
has db xref: Reactome:R-HSA-211247
has db xref: Reactome:R-HSA-5685994
has db xref: Reactome:R-HSA-6785986

Cleavage of DNA by DFF40
type: Axiom
annotated source: GO_0004536
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211247

Long-range resection of DNA DSBs by EXO1 or DNA2
type: Axiom
annotated source: GO_0004536
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5685994

DNA nucleases unhook the interstrand crosslink (ICL)
type: Axiom
annotated source: GO_0004536
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6785986

GO_0004549
has db xref: Reactome:R-HSA-5696813
has db xref: Reactome:R-HSA-5696815
has db xref: Reactome:R-HSA-6785722
has db xref: Reactome:R-HSA-6786854

TSEN complex cleaves the intron from pre-tRNA
type: Axiom
annotated source: GO_0004549
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696813

ELAC2 cleaves the 3' end of pre-tRNA
type: Axiom
annotated source: GO_0004549
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696815

Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript
type: Axiom
annotated source: GO_0004549
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6785722

Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript
type: Axiom
annotated source: GO_0004549
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786854

GO_0004550
has db xref: Reactome:R-HSA-2162096
has db xref: Reactome:R-HSA-482619
has db xref: Reactome:R-HSA-482621
has db xref: Reactome:R-HSA-482804
has db xref: Reactome:R-HSA-482812
has db xref: Reactome:R-HSA-6806877
has db xref: Reactome:R-HSA-9748969
has db xref: Reactome:R-HSA-9748999
has db xref: Reactome:R-HSA-9755013

carbovir diphosphate + ATP => carbovir triphosphate + ADP
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162096

(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-482619

(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-482621

(d)NDP + ATP <=> (d)NTP + ADP (NME4)
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-482804

(d)NTP + ADP <=> (d)NDP + ATP (NME4)
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-482812

NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6806877

NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748969

NME1:2 hexamer phosphorylates 6TGDP to 6TGTP
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748999

NME1,2 hexamers phosphorylate RBV-DP
type: Axiom
annotated source: GO_0004550
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755013

GO_0004551
has db xref: Reactome:R-HSA-196955

2xENPP1 hydrolyzes FAD to FMN
type: Axiom
annotated source: GO_0004551
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196955

GO_0004553
has db xref: Reactome:R-HSA-5694563
has db xref: Reactome:R-HSA-6786652
has db xref: Reactome:R-HSA-9661820

ABHD10 hydrolyses MPAG
type: Axiom
annotated source: GO_0004553
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694563

CHIT1 hydrolyses CHIT to 3xADGP
type: Axiom
annotated source: GO_0004553
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786652

Bacterial GUSB hydrolyses BDG to BIL
type: Axiom
annotated source: GO_0004553
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9661820

GO_0004555
has db xref: Reactome:R-HSA-188985

trehalose + H2O => 2 D-glucose
type: Axiom
annotated source: GO_0004555
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188985

GO_0004556
has db xref: Reactome:R-HSA-188979
has db xref: Reactome:R-HSA-191114

Digestion of linear starch (amylose) by extracellular amylase
type: Axiom
annotated source: GO_0004556
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188979

Digestion of branched starch (amylopectin) by extracellular amylase
type: Axiom
annotated source: GO_0004556
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191114

GO_0004557
has db xref: Reactome:R-HSA-1605736
has db xref: Reactome:R-HSA-9841189

GLA hydrolyzes PSAP(195-273):Gb3Cer:PE
type: Axiom
annotated source: GO_0004557
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605736

GLA hydrolyzes PSAP(195-273):Gal2Cer:PE
type: Axiom
annotated source: GO_0004557
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9841189

GO_0004558
has db xref: Reactome:R-HSA-189053
has db xref: Reactome:R-HSA-189102
has db xref: Reactome:R-HSA-191101
has db xref: Reactome:R-HSA-191108
has db xref: Reactome:R-HSA-191116
has db xref: Reactome:R-HSA-5659861
has db xref: Reactome:R-HSA-5659879
has db xref: Reactome:R-HSA-5659899
has db xref: Reactome:R-HSA-5659922

Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189053

maltose + H2O => 2 D-glucose (maltase-glucoamylase)
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189102

maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191101

maltose + H2O => 2 D-glucose (sucrase-isomaltase)
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191108

maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191116

isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659861

Defective SI does not hydrolyze iMal
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659879

Defective SI does not hydrolyze maltotriose
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659899

Defective SI does not hydrolyze Mal
type: Axiom
annotated source: GO_0004558
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659922

GO_0004559
has db xref: Reactome:R-HSA-6799545
has db xref: Reactome:R-HSA-8853686
has db xref: Reactome:R-HSA-9694656

MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5
type: Axiom
annotated source: GO_0004559
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799545

MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3
type: Axiom
annotated source: GO_0004559
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853686

Spike trimer glycoside chains are extended
type: Axiom
annotated source: GO_0004559
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694656

GO_0004560
has db xref: Reactome:R-HSA-5693807

FUCA1 hydrolyses NGP:1,6-GlcNAc
type: Axiom
annotated source: GO_0004560
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693807

GO_0004561
has db xref: Reactome:R-HSA-1678742
has db xref: Reactome:R-HSA-2090038
has db xref: Reactome:R-HSA-2263496
has db xref: Reactome:R-HSA-9036052

NAGLU hydrolyses Heparan sulfate chain(4)
type: Axiom
annotated source: GO_0004561
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678742

NAGLU hydrolyses heparan chain(2)
type: Axiom
annotated source: GO_0004561
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2090038

Defective NAGLU does not hydrolyse Heparan sulfate chain(4)
type: Axiom
annotated source: GO_0004561
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2263496

Defective NAGLU does not hydrolyse heparan chain(2)
type: Axiom
annotated source: GO_0004561
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036052

GO_0004563
has db xref: Reactome:R-HSA-1605595
has db xref: Reactome:R-HSA-1605632
has db xref: Reactome:R-HSA-1638053
has db xref: Reactome:R-HSA-2105001
has db xref: Reactome:R-HSA-2162225
has db xref: Reactome:R-HSA-3656259
has db xref: Reactome:R-HSA-3662344
has db xref: Reactome:R-HSA-9035976
has db xref: Reactome:R-HSA-9035978
has db xref: Reactome:R-HSA-9035982
has db xref: Reactome:R-HSA-9035983
has db xref: Reactome:R-HSA-9638075
has db xref: Reactome:R-HSA-9638076
has db xref: Reactome:R-HSA-9638078
has db xref: Reactome:R-HSA-9840833
has db xref: Reactome:R-HSA-9840884

bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605595

bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605632

HEXA cleaves the terminal GalNAc from keratan sulfate
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638053

HEXA cleaves the terminal GalNAc from DS
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2105001

HEXA cleaves the terminal GalNAc from small HA fragments
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162225

Defective HEXA does not cleave the terminal GalNAc from DS
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3656259

Defective HEXB does not cleave the terminal GalNAc from DS
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3662344

Defective HEXA does not cleave the terminall GalNAc from small HA fragments
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035976

Defective HEXA does not cleave the terminal GalNAc from keratan sulfate
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035978

Defective HEXB does not cleave the terminal GalNAc from HA fragments
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035982

Defective HEXB does not cleave the terminal GalNAc from keratan sulfate
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035983

HEXB cleaves the terminal GalNAc from DS
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638075

HEXB cleaves the terminal GalNAc from small HA fragments
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638076

HEXB cleaves the terminal GalNAc from keratan sulfate
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638078

bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840833

bHEXA,bHEXS hydrolyze GM2A:SM2
type: Axiom
annotated source: GO_0004563
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840884

GO_0004565
has db xref: Reactome:R-HSA-1605624
has db xref: Reactome:R-HSA-1606312
has db xref: Reactome:R-HSA-1630306
has db xref: Reactome:R-HSA-1793217
has db xref: Reactome:R-HSA-2090079
has db xref: Reactome:R-HSA-2265534
has db xref: Reactome:R-HSA-9036061
has db xref: Reactome:R-HSA-9840795

Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605624

GLB1 hydrolyzes SapB/C:LacCer
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606312

GLB1 hydrolyses a glycosaminoglycan
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1630306

Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1793217

GLB1 hydrolyses linker chain(2)
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2090079

Defective GLB1 does not hydrolyse a glycosaminoglycan
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2265534

Defective GLB1 does not hydrolyse linker chain(2)
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036061

Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2
type: Axiom
annotated source: GO_0004565
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9840795

GO_0004566
has db xref: Reactome:R-HSA-1678854
has db xref: Reactome:R-HSA-2162226
has db xref: Reactome:R-HSA-2162227
has db xref: Reactome:R-HSA-2318373
has db xref: Reactome:R-HSA-9036068
has db xref: Reactome:R-HSA-9036070

GUSB tetramer hydrolyses CS/HS precursor
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1678854

GUSB tetramer hydrolyses GlcA-1,3-GlcNAc
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162226

GUSB tetramer hydrolyses (HA)2
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2162227

Defective GUSB does not hydrolyse (HA)2
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2318373

Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036068

Defective GUSB does not hydrolyse CS/HS precursor
type: Axiom
annotated source: GO_0004566
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036070

GO_0004567
has db xref: Reactome:R-HSA-8853710

MANBA hydrolyses GlcNAc:Man
type: Axiom
annotated source: GO_0004567
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853710

GO_0004568
has db xref: Reactome:R-HSA-6786421

CHIA hydrolyses chitin
type: Axiom
annotated source: GO_0004568
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786421

GO_0004569
has db xref: Reactome:R-HSA-964759

Alternative endo-mannosidase I route
type: Axiom
annotated source: GO_0004569
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964759

GO_0004571
has db xref: Reactome:R-HSA-4793949
has db xref: Reactome:R-HSA-6782685
has db xref: Reactome:R-HSA-901024
has db xref: Reactome:R-HSA-901036
has db xref: Reactome:R-HSA-901039
has db xref: Reactome:R-HSA-901074
has db xref: Reactome:R-HSA-9036008
has db xref: Reactome:R-HSA-9036011
has db xref: Reactome:R-HSA-9036012
has db xref: Reactome:R-HSA-964737
has db xref: Reactome:R-HSA-964825
has db xref: Reactome:R-HSA-964830
has db xref: Reactome:R-HSA-9696807

Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4793949

EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782685

MAN1B1 hydrolyses 1,2-linked mannose (a branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-901024

MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-901036

MAN1B1 hydrolyses 1,2-linked mannose (c branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-901039

MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-901074

Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036008

Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036011

Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036012

Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964737

Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964825

Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964830

N-glycan mannose trimming of Spike
type: Axiom
annotated source: GO_0004571
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9696807

GO_0004572
has db xref: Reactome:R-HSA-975814

Trimming of mannoses on the alpha1,6 arm by MAN2A1
type: Axiom
annotated source: GO_0004572
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975814

GO_0004573
has db xref: Reactome:R-HSA-4793947
has db xref: Reactome:R-HSA-532678
has db xref: Reactome:R-HSA-9694364

Defective MOGS does not cleave glucose from an N-glycosylated protein
type: Axiom
annotated source: GO_0004573
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4793947

Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase
type: Axiom
annotated source: GO_0004573
annotated property: hasDbXref
annotated target: Reactome:R-HSA-532678

N-glycan glucose trimming of Spike
type: Axiom
annotated source: GO_0004573
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694364

GO_0004575
has db xref: Reactome:R-HSA-189069
has db xref: Reactome:R-HSA-5659926

sucrose + H2O => glucose + fructose
type: Axiom
annotated source: GO_0004575
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189069

Defective SI does not hydrolyze Suc
type: Axiom
annotated source: GO_0004575
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659926

GO_0004577
has db xref: Reactome:R-HSA-446207
has db xref: Reactome:R-HSA-5633241

ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP
type: Axiom
annotated source: GO_0004577
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446207

Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP
type: Axiom
annotated source: GO_0004577
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5633241

GO_0004578
has db xref: Reactome:R-HSA-446218
has db xref: Reactome:R-HSA-4549382

Addition of the first mannose to the N-glycan precursor by ALG1
type: Axiom
annotated source: GO_0004578
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446218

Defective ALG1 does not transfer the first Man to the N-glycan precursor
type: Axiom
annotated source: GO_0004578
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4549382

GO_0004579
has db xref: Reactome:R-HSA-446209
has db xref: Reactome:R-HSA-9694793

Transfer of N-glycan to the protein
type: Axiom
annotated source: GO_0004579
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446209

Spike protein gets N-glycosylated
type: Axiom
annotated source: GO_0004579
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694793

GO_0004581
has db xref: Reactome:R-HSA-446214

Synthesis of dolichyl-phosphate-glucose
type: Axiom
annotated source: GO_0004581
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446214

GO_0004582
has db xref: Reactome:R-HSA-162721
has db xref: Reactome:R-HSA-4717406
has db xref: Reactome:R-HSA-4719354
has db xref: Reactome:R-HSA-4719375

dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose
type: Axiom
annotated source: GO_0004582
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162721

Defective DPM1 does not transfer mannose to DOLP to form DOLPman
type: Axiom
annotated source: GO_0004582
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4717406

Defective DPM3 does not transfer mannose to DOLP to form DOLPman
type: Axiom
annotated source: GO_0004582
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4719354

Defective DPM2 does not transfer mannose to DOLP to form DOLPman
type: Axiom
annotated source: GO_0004582
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4719375

GO_0004583
has db xref: Reactome:R-HSA-446189
has db xref: Reactome:R-HSA-446194
has db xref: Reactome:R-HSA-446202
has db xref: Reactome:R-HSA-4724291
has db xref: Reactome:R-HSA-4724330

Addition of a second glucose to the N-glycan precursor by ALG8
type: Axiom
annotated source: GO_0004583
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446189

Addition of a third glucose to the N-glycan precursor by an ALG10 homologue
type: Axiom
annotated source: GO_0004583
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446194

Addition of the first glucose to the N-glycan precursor by ALG6
type: Axiom
annotated source: GO_0004583
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446202

Defective ALG6 does not add glucose to the N-glycan precursor
type: Axiom
annotated source: GO_0004583
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4724291

Defective ALG8 does not add glucose to the N-glycan precursor
type: Axiom
annotated source: GO_0004583
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4724330

GO_0004585
has db xref: Reactome:R-HSA-70560

carbamoyl phosphate + ornithine => citrulline + orthophosphate
type: Axiom
annotated source: GO_0004585
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70560

GO_0004586
has db xref: Reactome:R-HSA-70692

ornithine => putrescine + CO2
type: Axiom
annotated source: GO_0004586
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70692

GO_0004587
has db xref: Reactome:R-HSA-70654
has db xref: Reactome:R-HSA-70666

ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
type: Axiom
annotated source: GO_0004587
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70654

glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
type: Axiom
annotated source: GO_0004587
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70666

GO_0004588
has db xref: Reactome:R-HSA-73567

UMPS dimer transfers phosphoribosyl group to ORO to form OMP
type: Axiom
annotated source: GO_0004588
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73567

GO_0004590
has db xref: Reactome:R-HSA-73564

UMPS dimer decarboxylates OMP to UMP
type: Axiom
annotated source: GO_0004590
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73564

GO_0004594
has db xref: Reactome:R-HSA-196857
has db xref: Reactome:R-HSA-199203

PANK2 phosphorylates PanK
type: Axiom
annotated source: GO_0004594
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196857

PANK1/3 phosphorylate PanK
type: Axiom
annotated source: GO_0004594
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199203

GO_0004595
has db xref: Reactome:R-HSA-196754

COASY transfers an adenylyl group from ATP to PPANT
type: Axiom
annotated source: GO_0004595
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196754

GO_0004596
has db xref: Reactome:R-HSA-6814090

NatC acetylates ARFFRP1
type: Axiom
annotated source: GO_0004596
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814090

GO_0004601
has db xref: Reactome:R-HSA-1222346
has db xref: Reactome:R-HSA-140359
has db xref: Reactome:R-HSA-209815
has db xref: Reactome:R-HSA-209840
has db xref: Reactome:R-HSA-209925
has db xref: Reactome:R-HSA-209973
has db xref: Reactome:R-HSA-2309773
has db xref: Reactome:R-HSA-2559639
has db xref: Reactome:R-HSA-3341296
has db xref: Reactome:R-HSA-350901
has db xref: Reactome:R-HSA-5631885
has db xref: Reactome:R-HSA-6789031
has db xref: Reactome:R-HSA-6789126
has db xref: Reactome:R-HSA-8855490
has db xref: Reactome:R-HSA-8933635

AhpC reduces H2O2
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222346

PGG2 is reduced to PGH2 by PTGS1
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140359

Tyrosine is monoiodinated
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209815

Two DITs combine to form thyroxine
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209840

DIT and MIT combine to form triiodothyronine
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209925

Tyrosine is diiodinated
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209973

PGG2 is reduced to PGH2 by PTGS2
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2309773

Collagen type IV sulfilimine cross-linking by peroxidasin
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2559639

GPX7,8 catalyze peroxidation of P4HB (PDI)
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3341296

Iodide is organified
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350901

PRDX1 overoxidizes
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5631885

Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6789031

Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6789126

Lactoperoxidase (LPO) produces OSCN-
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855490

Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide
type: Axiom
annotated source: GO_0004601
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8933635

GO_0004602
has db xref: Reactome:R-HSA-2161791
has db xref: Reactome:R-HSA-2161946
has db xref: Reactome:R-HSA-2161959
has db xref: Reactome:R-HSA-2161999
has db xref: Reactome:R-HSA-3323013
has db xref: Reactome:R-HSA-3341277
has db xref: Reactome:R-HSA-3341397
has db xref: Reactome:R-HSA-3343700
has db xref: Reactome:R-HSA-6799695
has db xref: Reactome:R-HSA-71676

15S-HpETE is reduced to 15S-HETE by GPX1/2/4
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161791

5S-HpETE is reduced to 5S-HETE by GPX1/2/4
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161946

12R-HpETE is reduced to 12R-HETE by GPX1/2/4
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161959

12S-HpETE is reduced to 12S-HETE by GPX1/2/4
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161999

GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3323013

GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3341277

GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3341397

PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3343700

GPX5,6 reduce H2O2 to H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799695

GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
type: Axiom
annotated source: GO_0004602
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71676

GO_0004603
has db xref: Reactome:R-HSA-209903

Noradrenaline is converted to adrenaline
type: Axiom
annotated source: GO_0004603
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209903

GO_0004605
has db xref: Reactome:R-HSA-1483121
has db xref: Reactome:R-HSA-1483165

PA is converted to CDP-DAG by CDS1
type: Axiom
annotated source: GO_0004605
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483121

PA is converted to CDP-DAG by CDS2
type: Axiom
annotated source: GO_0004605
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483165

GO_0004607
has db xref: Reactome:R-HSA-264695

cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
type: Axiom
annotated source: GO_0004607
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264695

GO_0004608
has db xref: Reactome:R-HSA-1483174

PE is methylated to PC by PEMT
type: Axiom
annotated source: GO_0004608
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483174

GO_0004609
has db xref: Reactome:R-HSA-1483212

PS is decarboxylated to PE by PISD
type: Axiom
annotated source: GO_0004609
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483212

GO_0004610
has db xref: Reactome:R-HSA-446185

Isomerization of GlcNAc6P to GlcNAc1P
type: Axiom
annotated source: GO_0004610
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446185

GO_0004613
has db xref: Reactome:R-HSA-372819
has db xref: Reactome:R-HSA-70241

PCK2 phosphorylates OA to yield PEP
type: Axiom
annotated source: GO_0004613
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372819

PCK1 phosphorylates OA to yield PEP
type: Axiom
annotated source: GO_0004613
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70241

GO_0004614
has db xref: Reactome:R-HSA-5609939
has db xref: Reactome:R-HSA-9638125
has db xref: Reactome:R-HSA-9638127

Defective PGM1 does not isomerise G6P to G1P
type: Axiom
annotated source: GO_0004614
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5609939

PGM1:Mg2+ isomerises G1P to G6P
type: Axiom
annotated source: GO_0004614
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638125

PGM1:Mg2+ isomerises G6P to G1P
type: Axiom
annotated source: GO_0004614
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9638127

GO_0004615
has db xref: Reactome:R-HSA-3781926
has db xref: Reactome:R-HSA-446201

Defective PMM2 does not isomerise Man6P to Man1P
type: Axiom
annotated source: GO_0004615
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3781926

PMM1,2 isomerise Man6P to Man1P
type: Axiom
annotated source: GO_0004615
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446201

GO_0004616
has db xref: Reactome:R-HSA-71299

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
type: Axiom
annotated source: GO_0004616
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71299

GO_0004617
has db xref: Reactome:R-HSA-977348

PHGDH tetramer dehydrogenates 3PG
type: Axiom
annotated source: GO_0004617
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977348

GO_0004618
has db xref: Reactome:R-HSA-70486
has db xref: Reactome:R-HSA-71850

PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG
type: Axiom
annotated source: GO_0004618
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70486

1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP
type: Axiom
annotated source: GO_0004618
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71850

GO_0004619
has db xref: Reactome:R-HSA-71445
has db xref: Reactome:R-HSA-71654

PGAM dimers (PGAM1,2) isomerise 2PG to 3PG
type: Axiom
annotated source: GO_0004619
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71445

3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate
type: Axiom
annotated source: GO_0004619
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71654

GO_0004620
has db xref: Reactome:R-HSA-6786650
has db xref: Reactome:R-HSA-6792445

DDHD1,2 hydrolyse PA
type: Axiom
annotated source: GO_0004620
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786650

LIPH, I hydrolyse PA to 2-acyl LPA
type: Axiom
annotated source: GO_0004620
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6792445

GO_0004621
has db xref: Reactome:R-HSA-8940388

GPLD1 hydrolyses GPI-anchors from proteins
type: Axiom
annotated source: GO_0004621
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940388

GO_0004622
has db xref: Reactome:R-HSA-1482545
has db xref: Reactome:R-HSA-1482571
has db xref: Reactome:R-HSA-1482612
has db xref: Reactome:R-HSA-1482629
has db xref: Reactome:R-HSA-1482685
has db xref: Reactome:R-HSA-1482696
has db xref: Reactome:R-HSA-6814254
has db xref: Reactome:R-HSA-6814766
has db xref: Reactome:R-HSA-6814778
has db xref: Reactome:R-HSA-8847912

2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482545

1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482571

2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482612

2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482629

1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482685

1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482696

PNPLA6 hydrolyzes LysoPtdCho
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814254

GDPD1 hydrolyzes LysoPtdCho
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814766

GDPD3 hydrolyzes LysoPtdCho
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814778

PNPLA7 hydrolyzes LysoPtdCho
type: Axiom
annotated source: GO_0004622
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8847912

GO_0004623
has db xref: Reactome:R-HSA-1482604
has db xref: Reactome:R-HSA-1482656
has db xref: Reactome:R-HSA-1482679
has db xref: Reactome:R-HSA-1482745
has db xref: Reactome:R-HSA-1482759
has db xref: Reactome:R-HSA-1482771
has db xref: Reactome:R-HSA-1482776
has db xref: Reactome:R-HSA-1482778
has db xref: Reactome:R-HSA-1482816
has db xref: Reactome:R-HSA-1482825
has db xref: Reactome:R-HSA-1482856
has db xref: Reactome:R-HSA-1482868
has db xref: Reactome:R-HSA-1482884
has db xref: Reactome:R-HSA-1482887
has db xref: Reactome:R-HSA-1482897
has db xref: Reactome:R-HSA-1482900
has db xref: Reactome:R-HSA-1482907
has db xref: Reactome:R-HSA-1602368
has db xref: Reactome:R-HSA-1602374
has db xref: Reactome:R-HSA-1602377
has db xref: Reactome:R-HSA-1602398
has db xref: Reactome:R-HSA-1602399
has db xref: Reactome:R-HSA-1602417
has db xref: Reactome:R-HSA-1602446
has db xref: Reactome:R-HSA-8848484

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482604

PA is hydrolysed to 1-acyl LPA by PLA2[1]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482656

PA is hydrolysed to 1-acyl LPA by PLA2G2A
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482679

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482745

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482759

PS is hydrolyzed to 1-acyl LPS by PLA2[9]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482771

PS is hydrolyzed to 1-acyl LPS by PLA2G2A
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482776

CL is hydrolyzed to MLCL by PLA2G6 (IM)
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482778

PC is hydrolyzed to 1-acyl LPC by PLA2[6]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482816

PI is hydrolyzed to 1-acyl LPI by PLA2[11]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482825

PC is hydrolyzed to 1-acyl LPC by PLA2[5]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482856

PI is hydrolyzed to 1-acyl LPI by PLA2[12]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482868

PE is hydrolyzed to 1-acyl LPE by PLA2[2]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482884

PE is hydrolyzed to 1-acyl LPE by PLA2[3]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482887

PS is hydrolyzed to 2-acyl LPS by PLA2[10]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482897

PG is hydrolyzed to 1-acyl LPG by PLA2[1]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482900

PG is hydrolyzed to 1-acyl LPG by PLA2G2A
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482907

PG is hydrolyzed to 1-acyl LPG by PLA2[16]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602368

PS is hydrolyzed to 1-acyl LPS by PLA2[15]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602374

PI is hydrolyzed to 1-acyl LPI by PLA2[15]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602377

PE is hydrolyzed to 1-acyl LPE by PLA2[16]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602398

PC is hydrolyzed to 1-acyl LPC by PLB1
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602399

PC is hydrolyzed to 1-acyl LPC by PLA2[16]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602417

PA is hydrolyzed to 1-acyl LPA by PLA2[15]
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1602446

PLA2s hydrolyze phospholipids at the Golgi membrane
type: Axiom
annotated source: GO_0004623
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848484

GO_0004629
has db xref: Reactome:R-HSA-1112666
has db xref: Reactome:R-HSA-114688
has db xref: Reactome:R-HSA-114689
has db xref: Reactome:R-HSA-398193
has db xref: Reactome:R-HSA-399998
has db xref: Reactome:R-HSA-5362553

BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1112666

PLC-beta hydrolyses PIP2 to DAG and IP3
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114688

PLC gamma 2-mediated PIP2 hydrolysis
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114689

PLC beta-mediated PIP2 hydrolysis
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-398193

Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399998

NOTUM releases Hh-Np:GPC5 from the plasma membrane
type: Axiom
annotated source: GO_0004629
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362553

GO_0004630
has db xref: Reactome:R-HSA-1483142
has db xref: Reactome:R-HSA-1483182
has db xref: Reactome:R-HSA-2029471

PC is transphosphatidylated to PG by PLD1-4/6
type: Axiom
annotated source: GO_0004630
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483142

PC is hydrolyzed to PA and choline by PLD1/2
type: Axiom
annotated source: GO_0004630
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483182

Hydrolysis of PC to PA by PLD
type: Axiom
annotated source: GO_0004630
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029471

GO_0004631
has db xref: Reactome:R-HSA-191422

Mevalonate-5-phosphate is further phosphorylated.
type: Axiom
annotated source: GO_0004631
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191422

GO_0004632
has db xref: Reactome:R-HSA-196753

2xPPCS ligates PPanK with Cys
type: Axiom
annotated source: GO_0004632
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196753

GO_0004633
has db xref: Reactome:R-HSA-196840

3xPPCDC:3FMN decarboxylates PPC
type: Axiom
annotated source: GO_0004633
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196840

GO_0004634
has db xref: Reactome:R-HSA-70494
has db xref: Reactome:R-HSA-71660

Enolase dimers (ENO1,2,3) convert PEP to 2PG
type: Axiom
annotated source: GO_0004634
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70494

2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O
type: Axiom
annotated source: GO_0004634
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71660

GO_0004637
has db xref: Reactome:R-HSA-73814

5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
type: Axiom
annotated source: GO_0004637
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73814

GO_0004638
has db xref: Reactome:R-HSA-73806

AIR + CO2 => CAIR
type: Axiom
annotated source: GO_0004638
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73806

GO_0004639
has db xref: Reactome:R-HSA-73805

CAIR + Aspartate + ATP => SAICAR + ADP + Pi
type: Axiom
annotated source: GO_0004639
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73805

GO_0004641
has db xref: Reactome:R-HSA-73810

FGAM + ATP => AIR + ADP + Pi
type: Axiom
annotated source: GO_0004641
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73810

GO_0004642
has db xref: Reactome:R-HSA-73812

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi
type: Axiom
annotated source: GO_0004642
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73812

GO_0004643
has db xref: Reactome:R-HSA-73798

AICAR + 10-Formyl-THF => FAICAR + THF
type: Axiom
annotated source: GO_0004643
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73798

GO_0004644
has db xref: Reactome:R-HSA-73813

GAR + 10-Formyl-THF => FGAR + THF
type: Axiom
annotated source: GO_0004644
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73813

GO_0004648
has db xref: Reactome:R-HSA-977333

PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA
type: Axiom
annotated source: GO_0004648
annotated property: hasDbXref
annotated target: Reactome:R-HSA-977333

GO_0004649
has db xref: Reactome:R-HSA-5651828
has db xref: Reactome:R-HSA-8952903

PARG dePARylates PARP1,PARP2
type: Axiom
annotated source: GO_0004649
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651828

ADPRHL2 hydrolyses poly(ADP-ribose)
type: Axiom
annotated source: GO_0004649
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8952903

GO_0004651
has db xref: Reactome:R-HSA-77078

Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
type: Axiom
annotated source: GO_0004651
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77078

GO_0004653
has db xref: Reactome:R-HSA-5096532
has db xref: Reactome:R-HSA-5096537
has db xref: Reactome:R-HSA-8851619
has db xref: Reactome:R-HSA-913675
has db xref: Reactome:R-HSA-9683760
has db xref: Reactome:R-HSA-9694438

Defective GALNT12 does not transfer GalNAc to mucins
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5096532

Defective GALNT3 does not transfer GalNAc to mucins
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5096537

GALNT3 transfers GalNAc to FGF23
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851619

GALNTs transfer GalNAc to Mucins to form Tn antigens
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-913675

GalNAc is transferred onto 3a
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9683760

GalNAc is transferred onto 3a
type: Axiom
annotated source: GO_0004653
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694438

GO_0004655
has db xref: Reactome:R-HSA-189439

ALAD condenses 2 dALAs to form PBG
type: Axiom
annotated source: GO_0004655
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189439

GO_0004656
has db xref: Reactome:R-HSA-1650808

Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines
type: Axiom
annotated source: GO_0004656
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1650808

GO_0004657
has db xref: Reactome:R-HSA-6784224
has db xref: Reactome:R-HSA-70670
has db xref: Reactome:R-HSA-8955817

PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate
type: Axiom
annotated source: GO_0004657
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784224

PRODH oxidises L-Pro to 1PYR-5COOH
type: Axiom
annotated source: GO_0004657
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70670

PRODH2 oxidises HPRO to 1PYR-5COOH
type: Axiom
annotated source: GO_0004657
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8955817

GO_0004658
has db xref: Reactome:R-HSA-71031

propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate
type: Axiom
annotated source: GO_0004658
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71031

GO_0004659
has db xref: Reactome:R-HSA-6806674

UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)
type: Axiom
annotated source: GO_0004659
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6806674

GO_0004660
has db xref: Reactome:R-HSA-2530501
has db xref: Reactome:R-HSA-9647978

FNTA:FNTB transfers FARN to GNGT1
type: Axiom
annotated source: GO_0004660
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2530501

pro-RAS proteins are farnesylated
type: Axiom
annotated source: GO_0004660
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647978

GO_0004666
has db xref: Reactome:R-HSA-140355
has db xref: Reactome:R-HSA-2309787

Arachidonic acid is oxidised to PGG2 by PTGS1
type: Axiom
annotated source: GO_0004666
annotated property: hasDbXref
annotated target: Reactome:R-HSA-140355

Arachidonic acid is oxidised to PGG2 by PTGS2
type: Axiom
annotated source: GO_0004666
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2309787

GO_0004667
has db xref: Reactome:R-HSA-2161620
has db xref: Reactome:R-HSA-2161701

PGH2 is isomerised to PGD2 by PTGDS
type: Axiom
annotated source: GO_0004667
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161620

PGH2 is isomerised to PGD2 by HPGDS
type: Axiom
annotated source: GO_0004667
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161701

GO_0004668
has db xref: Reactome:R-HSA-1183128
has db xref: Reactome:R-HSA-3247569

PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins
type: Axiom
annotated source: GO_0004668
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1183128

PADI4 deiminates Histones
type: Axiom
annotated source: GO_0004668
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3247569

GO_0004671
has db xref: Reactome:R-HSA-6788650
has db xref: Reactome:R-HSA-9647977

ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
type: Axiom
annotated source: GO_0004671
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6788650

ICMT methylates S-Farn RAS proteins
type: Axiom
annotated source: GO_0004671
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647977

GO_0004672
has db xref: Reactome:R-HSA-156832
has db xref: Reactome:R-HSA-937034
has db xref: Reactome:R-HSA-9604606
has db xref: Reactome:R-HSA-9673284
has db xref: Reactome:R-HSA-9732753
has db xref: Reactome:R-HSA-975139
has db xref: Reactome:R-HSA-9833820
has db xref: Reactome:R-HSA-9835885
has db xref: Reactome:R-HSA-9836159
has db xref: Reactome:R-HSA-9836184
has db xref: Reactome:R-HSA-9836322
has db xref: Reactome:R-HSA-9836362
has db xref: Reactome:R-HSA-9836383
has db xref: Reactome:R-HSA-9836404
has db xref: Reactome:R-HSA-9836435
has db xref: Reactome:R-HSA-9836449
has db xref: Reactome:R-HSA-9836515
has db xref: Reactome:R-HSA-9836617
has db xref: Reactome:R-HSA-9836664

INF-gamma induced phosphorylation of L13a
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156832

IRAK1 phosphorylates Pellino
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-937034

Unknown kinase phosphorylates NICD4
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604606

GTP-bound RAC1 contributes to MAPK8 activation
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673284

JAK1-activated RAF1 phosphorylates MAPKs
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9732753

IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975139

PKR dimer autophosphorylates
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9833820

p-PKR dimer phosphorylates eIF2-alpha
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9835885

p-PKR dimer phosphorylates DHX9
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836159

p-PKR dimer phosphorylates CDK1
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836184

p-PKR dimer phosphorylates MKK6
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836322

p-PKR dimer phosphorylates TP53 tetramer
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836362

p-PKR dimer phosphorylates ILF3:ILF2
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836383

p-PKR dimer phosphorylates MAPT
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836404

p-PKR dimer phosphorylates SNCA
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836435

p-PKR dimer phosphorylates HIV tat
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836449

p-PKR dimer phosphorylates PTPN2
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836515

p-PKR dimer phosphorylates SPHK1
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836617

p-PKR dimer phosphorylates PPP2R5A
type: Axiom
annotated source: GO_0004672
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9836664

GO_0004674
has db xref: Reactome:R-HSA-109702
has db xref: Reactome:R-HSA-109822
has db xref: Reactome:R-HSA-109823
has db xref: Reactome:R-HSA-109860
has db xref: Reactome:R-HSA-109862
has db xref: Reactome:R-HSA-111919
has db xref: Reactome:R-HSA-111970
has db xref: Reactome:R-HSA-112342
has db xref: Reactome:R-HSA-112381
has db xref: Reactome:R-HSA-1168635
has db xref: Reactome:R-HSA-1168638
has db xref: Reactome:R-HSA-1168641
has db xref: Reactome:R-HSA-1181149
has db xref: Reactome:R-HSA-1181156
has db xref: Reactome:R-HSA-1181355
has db xref: Reactome:R-HSA-1225894
has db xref: Reactome:R-HSA-1358791
has db xref: Reactome:R-HSA-1362270
has db xref: Reactome:R-HSA-139908
has db xref: Reactome:R-HSA-139918
has db xref: Reactome:R-HSA-1445144
has db xref: Reactome:R-HSA-1449597
has db xref: Reactome:R-HSA-1454699
has db xref: Reactome:R-HSA-1458463
has db xref: Reactome:R-HSA-1549526
has db xref: Reactome:R-HSA-156673
has db xref: Reactome:R-HSA-156678
has db xref: Reactome:R-HSA-156682
has db xref: Reactome:R-HSA-156699
has db xref: Reactome:R-HSA-156723
has db xref: Reactome:R-HSA-1592233
has db xref: Reactome:R-HSA-162363
has db xref: Reactome:R-HSA-162657
has db xref: Reactome:R-HSA-163010
has db xref: Reactome:R-HSA-1632857
has db xref: Reactome:R-HSA-163416
has db xref: Reactome:R-HSA-163418
has db xref: Reactome:R-HSA-1638803
has db xref: Reactome:R-HSA-164151
has db xref: Reactome:R-HSA-165162
has db xref: Reactome:R-HSA-165182
has db xref: Reactome:R-HSA-165692
has db xref: Reactome:R-HSA-165718
has db xref: Reactome:R-HSA-165726
has db xref: Reactome:R-HSA-165758
has db xref: Reactome:R-HSA-165766
has db xref: Reactome:R-HSA-165777
has db xref: Reactome:R-HSA-166119
has db xref: Reactome:R-HSA-166245
has db xref: Reactome:R-HSA-166284
has db xref: Reactome:R-HSA-166286
has db xref: Reactome:R-HSA-167084
has db xref: Reactome:R-HSA-167098
has db xref: Reactome:R-HSA-168053
has db xref: Reactome:R-HSA-168140
has db xref: Reactome:R-HSA-168184
has db xref: Reactome:R-HSA-170055
has db xref: Reactome:R-HSA-170076
has db xref: Reactome:R-HSA-170087
has db xref: Reactome:R-HSA-170116
has db xref: Reactome:R-HSA-170126
has db xref: Reactome:R-HSA-170977
has db xref: Reactome:R-HSA-174119
has db xref: Reactome:R-HSA-174174
has db xref: Reactome:R-HSA-176116
has db xref: Reactome:R-HSA-176298
has db xref: Reactome:R-HSA-187688
has db xref: Reactome:R-HSA-187949
has db xref: Reactome:R-HSA-188350
has db xref: Reactome:R-HSA-193647
has db xref: Reactome:R-HSA-193705
has db xref: Reactome:R-HSA-195275
has db xref: Reactome:R-HSA-195283
has db xref: Reactome:R-HSA-195287
has db xref: Reactome:R-HSA-195300
has db xref: Reactome:R-HSA-195318
has db xref: Reactome:R-HSA-198270
has db xref: Reactome:R-HSA-198347
has db xref: Reactome:R-HSA-198371
has db xref: Reactome:R-HSA-198599

PDPK1 phosphorylates AKT2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109702

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109822

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109823

MAP2K1 phosphorylates MAPK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109860

MAP2K2 phosphorylates MAPK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109862

PKA phosphorylates CREB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111919

PKC phosphorylates GRK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111970

Inactivation of MAP2K1 by CDK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112342

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112381

PRKCB (PKC-beta) phosphorylates CARMA1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168635

Activated IKK phosphorylates I-kappaB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168638

TAK1 associated with the CBM complex phosphorylates IKKbeta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168641

ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1181149

Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1181156

Phosphorylation of R-SMAD2/3 by NODAL receptor
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1181355

Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1225894

Phosphorylation of USP8 by P-AKT
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1358791

Phosphorylation of LIN52 component of MuvB by DYRK1A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1362270

Phosphorylation of DLC2 by MAPK8
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139908

Phosphorylation of BIM by JNK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139918

p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1445144

p-AKT2 phosphorylates Myosin 5A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1449597

AMPK-alpha2 phosphorylates TBC1D1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1454699

p-AKT2 phosphorylates RGC2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1458463

Phosphorylation of SMAD2,3 by Activin:Activin Receptor
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1549526

Regulation of KIF23 (MKLP1) by phosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156673

Activation of Cdc25C
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156678

PLK1 phosphorylates NUDC
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156682

Inactivation of Wee1 kinase
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156699

Regulation of KIF20A (MKL2) by phosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156723

p38 MAPK phosphorylates PPARGC1A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592233

p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162363

Inactivation of Myt1 kinase
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162657

Down Regulation of Emi1 through Phosphorylation of Emi1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163010

ULK1 phosphorylates AMBRA1:BECN1 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1632857

hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163416

perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163418

Phosphorylation of cohesin by PLK1 at centromeres
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638803

LKB1 phosphorylates the alpha subunit of AMPK heterotrimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164151

Phosphorylation of TSC2 by PKB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165162

Phosphorylation of complexed TSC2 by PKB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165182

Phosphorylation of 4E-BP1 by activated mTORC1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165692

mTORC1 phosphorylation of RPS6KB1 (S6K)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165718

Phosphorylation of Ribosomal protein S6 by activated S6K1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165726

Phosphorylation and inactivation of eEF2K by activated S6K1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165758

Phosphorylation and activation of eIF4G by activated S6K1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165766

Phosphorylation and activation of eIF4B by activated S6K1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-165777

First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166119

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166245

Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166284

Multiple IRAK1 autophosphorylation steps
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166286

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167084

Phosphorylation (Ser5) of RNA pol II CTD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167098

Phosphorylated MAPKs phosphorylate ATF-2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168053

Active IKK Complex phosphorylates NF-kappa-B inhibitor
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168140

Activated TAK1 mediates phosphorylation of the IKK Complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168184

Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170055

CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170076

CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170087

Myt-1 mediated phosphorylation of Cyclin A:Cdc2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170116

Phosphorylation of Cyclin B1 in the CRS domain
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170126

FRS2 is phosphorylated by active TrkA receptor
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170977

Free APC/C phosphorylated by Plk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174119

Phosphorylation of the Emi1 DSGxxS degron by Plk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174174

Recruitment and activation of Chk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176116

Activation of claspin
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176298

p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187688

CAK-mediated phosphorylation of Cyclin A:Cdk2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187949

CAK-mediated phosphorylation of Cyclin E:Cdk2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188350

IRAK is activated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193647

IKKbeta phosphorylates IkB causing NF-kB to dissociate
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193705

Phosphorylation of APC component of the destruction complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195275

Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195283

Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195287

Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195300

Phosphorylation of beta-catenin at Ser45 by CK1 alpha
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195318

PDPK1 phosphorylates AKT at T308
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198270

AKT phosphorylates BAD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198347

AKT phosphorylates GSK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198371

AKT phosphorylates MDM2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198599

AKT phosphorylates TSC2, inhibiting it
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198609

AKT phosphorylates IKKalpha
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198611

AKT phosphorylates p21Cip1 and p27Kip1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198613

AKT phosphorylates caspase-9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198621

TORC2 (mTOR) phosphorylates AKT at S473
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198640

p38MAPK phosphorylates MSK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198669

ERK1/2 activates ELK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198731

ERK1/2/5 activate RSK1/2/3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198746

ERK1/2 phosphorylates MSK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198756

AKT phosphorylates CREB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199298

AKT phosphorylates FOXO transcription factors
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199299

AKT can phosphorylate RSK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199839

AKT can phosphorylate NR4A1 (NUR77)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199863

RSK1/2/3 phosphorylates CREB at Serine 119
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199895

MSK1 activates ATF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199910

MAPKAPK2 phosphorylates CREB at Serine 133
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199917

ERK5 activates the transcription factor MEF2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199929

MSK1 activates CREB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199935

AKT phosphorylates AKT1S1 (PRAS40)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200143

Activation of cytosolic AMPK by phosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200421

Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201677

Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201691

CSNK2-mediated phosphorylation of DVL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201717

Phosphorylation of PKC theta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202222

Phosphorylation of CARMA1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202437

Phosphorylation of Bcl10
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202459

Activation of IKK complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202500

Activation of TAK1-TAB2 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202510

p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202541

Phosphorylation of STK4 (MST1) and SAV1 by STK4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028284

Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028555

Phosphorylation of YAP by LATS2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028583

Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028589

Phosphorylation of STK3 (MST2) and SAV1 by STK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028591

Phosphorylation of YAP by LATS1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028598

Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028629

Phosphorylation of MOB1A and B by p-STK3 (p-MST2)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028635

Phosphorylation of WWTR1 (TAZ) by LATS2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028661

Phosphorylation of MOB1A and B by p-STK4(MST1)/N
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028670

Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028673

Phosphorylation of MOB1A and B by p-STK3(MST2)/N
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028675

Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2028679

Autophosphorylation of PAK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029454

PAK1 phosphorylates LIMK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029460

p-ERK phosphorylates WAVEs and ABI
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029469

Phosphorylation of WWTR1 (TAZ) by LATS1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2060328

IKBA is phosphorylated by Phospho IKKB kinase
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209087

AKT phosphorylates FOXO1A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211164

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211583

Autophosphorylation of PAK-2p34 in the activation loop
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211650

MASTL (GWL) phosphorylates ARPP19
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2168079

Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2176475

PLK1 phosphorylates GORASP1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2214351

AKT1 E17K mutant is phosphorylated by TORC2 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2243938

PDPK1 phosphorylates AKT1 E17K mutant
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2243942

PLK1 hyperphosphorylates Condensin II complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2294580

IRF3 is phosphorylated by TBK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2396007

AKT1 E17K mutant phosphorylates BAD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399941

AKT1 E17K mutant phosphorylates GSK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399966

AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399969

AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399977

AKT1 E17K mutant phosphorylates MDM2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399981

AKT1 E17K mutant phosphorylates TSC2, inhibiting it
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399982

AKT1 E17K mutant phosphorylates caspase-9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399985

AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399988

AKT1 E17K mutant phosphorylates forkhead box transcription factors
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399992

AKT1 E17K mutant phosphorylates CREB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399996

AKT1 E17K mutant phosphorylates RSK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2399999

AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2400001

MAPK3-3 or MAPK1 phosphorylate GORASP2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2422927

MASTL phosphorylates ENSA
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2430535

Phosphorylation of cohesin by PLK1 at chromosomal arms
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2466068

ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2470508

CK2 phosphorylates condensin I subunits
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2529020

PLK1 phosphorylates OPTN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2562526

AJUBA facilitates AURKA autophosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2574840

Autophosphorylation of PAK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730856

Phosphorylation of MEK7 by MEKK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730868

Phosphorylation of IKK-beta by TAK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730876

Phosphorylation of MEK4 by MEKK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730896

Activation of TAK1 complex bound to pUb-TRAF6
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730900

PLK1 phosphorylates NEK9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2984226

NEK9 phosphorylates NEK6/NEK7
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2984258

NEK6/NEK7 phosphorylates NUP98
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2990880

VRK1/VRK2 phosphorylate BANF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2993898

AURKA phosphorylates PLK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3000310

PLK1 phosphorylates BORA
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3000327

MAPKs phosphorylate ETS1 and ETS2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3132737

Activated ERKs phosphorylate ERF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3209160

STK11 (LKB1) phosphorylates NUAK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3222006

NUAK1 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3222020

MAP3K5 phosphorylates MKK3 and MKK6
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3228469

p-MAPKAPK3 phosphorylates BMI1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3229102

MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3229152

MAPKAPK5 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3239014

Active p38 MAPK phosphorylates MAPKAPK5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3239019

TBK1 phosphorylates STAT6 at Ser407
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3249371

Constitutive phosphorylation by GSK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3371435

Constitutive phosphorylation by pERK1/2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3371531

DBC1 is phosphorylated by ATM/ART
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3371567

Phosphorylation of MDM4 by CHEK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-349426

Phosphorylation of COP1 at Ser-387 by ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-349444

Phosphorylation of MDM4 by ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-349455

Phosphorylation of L1 by p90rsk
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374696

AKT phosphorylates CBY1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3769394

Activated Akt1 phosphorylates AKT1S1 (PRAS40)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-377186

WNT signaling stimulates CSNK1-dependent phosphorylation of DVL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3772435

Plk1-mediated phosphorylation of Nlp
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380272

IRE1 dimer autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381091

EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-381111

RPS6KA1/2/3 phosphorylates CEBPB on S321
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3857328

MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3857329

WNT-dependent phosphorylation of DVL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3858480

AKT interacts and phosphorylates Cot
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389756

Phosphorylation of L1 by CK-II
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392752

ROCK phosphorylates LIMK1,2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928577

LIMK phosphorylates CFL1, inactivating it
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928608

Activated ROCK phosphorylates MRLCs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928616

PAK1 autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928620

PAKs autophosphorylate
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928625

PAKs phosphorylate MLC
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928640

Autophosphorylation of PAK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399939

Phosphorylation of CRMPs by Cdk5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399944

Phosphorylation of cofilin by LIMK-1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399950

Phosphorylation of CRMPs by GSK3beta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399951

Phosphorylation of LIMK-1 by PAK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399952

Protein kinase C, alpha type phosphorylates MARCKS
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399978

CSNK1E,CSNK1D phosphorylate CRY and PER proteins
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-400382

PLK1 phosphorylates FOXM1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4088134

Myosin phosphatase inactivation by ROCK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419083

LIM kinase phosphorylation by ROCK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419087

Myosin regulatory light chain phosphorylation by ROCK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419197

Transphosphorylation of pLIMK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419644

Phosphorylation of cPLA2 by MAPK p38 alpha
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428961

ALOX5 is phosphorylated by MAPKAP2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429016

CSNK1G2 phosphorylates p-CERT1-2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429714

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432110

Dissociation of CaM and CAMK2 autophosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4332358

Autophosphorylation and activation of CAMK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4332363

Activation of MAP3K7 in response to WNT
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4332388

NLK phosphorylates TCF/LEF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4411383

Activation of NLK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4411402

Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442724

PDPK1 phosphorylates RSKs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442739

PAK phosphorylates cortactin
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442832

Interaction of PAK1 with Rac1-GTP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445072

IRAK4 phosphorylates IRAK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446694

IRAK4-activated IRAK1 autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446701

Phosphorylation of E proteins by p38 MAPK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-448948

Phosphorylation of MEF2 proteins by p38
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-448955

Active p38 MAPK phosphorylates MAPKAPK2 or 3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450222

c-FOS activation by phospho ERK1/2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450325

Activated TAK1 phosphorylates MKK4/MKK7
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450337

activated human TAK1 phosphorylates MKK3/MKK6
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450346

MK2 phosphorylates ZFP36 (Tristetraproline, TTP)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450463

MK2 phosphorylates BRF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450474

Protein Kinase B/Akt phosphorylates BRF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450490

Protein Kinase B (AKT) phosphorylates KSRP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450499

hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450827

MAP kinase p38 phosphorylates KSRP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451152

Activation of JNK by DSCAM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451347

VANGL2 is phosphorylated in response to WNT5A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4551570

DVL2 is phosphorylated after WNT5A binding to FZD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4608825

MAPKAPK2 phosphorylates HSF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4793911

Phosphorylation of HSF1 at Ser230 induces transactivation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5082387

Phosphorylation of HSF1 at Ser326 induces transactivation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5082405

RIPK1 is phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5213464

RIPK3 is phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5213466

PAK2 autophorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218814

PDK1 phosphorylates PKC
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218821

Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218826

p-Y420-FYN is phosphorylated on S21
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218854

RIPK3 phosphorylates MLKL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218906

p-MAPK2/3 phosphorylates HSP27
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218916

NFKBIA variant is not phosphorylated within IkBA:NF-kappaB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5228811

AXIN is phosphorylated in the destruction complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5229343

p-AKT2 phosphorylates C2CD5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5260201

PAK1-3 autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357472

PAK1-3 phosphorylates VE-cadherin
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357477

CHUK, IKBKB phosphorylate CYLD at S418
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357831

DMPK phosphorylates PLN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5578777

Active NIK phosphorylates IKKA dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607722

Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607726

K63polyUb-TAK1 autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607732

K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607742

CK1 phosphorylates p-GLI2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610718

CK1 phosphorylates p-GLI3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610722

GSK3 phosphorylates p-GLI2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610730

GSK3 phosphorylates p-GLI3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610732

Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5624473

PAK phosphorylates p21 RAF1 on S338
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5624492

Autophosphorylation of PAK1,2,3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5627775

CSNK1A1 phosphorylates SMO dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5632670

ADRBK1 phosphorylates SMO dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5632672

GLI proteins are phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5635841

ULK3 phosphorylates GLI
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5635842

AMPK (complex) phosphorylates ULK1 (complex)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5665868

AURKB phosphorylates DIAPH2-2 at kinetochores
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5666160

NIK autophosphorylates on T559
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668545

PAK2 phosphorylates myosin regulatory light chain (MRLC)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668932

PAK1 phosphorylates myosin phosphatase
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668947

PAK1 or PAK2 phosphorylates MYLK
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668984

PAK1 phosphorylates FLNA
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5669250

p-T774-PKN1 phosphorylates PPP1R14A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5671763

Activated CIT phosphorylates MRLCs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5671919

Thr-180 of ULK1 is phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672008

Active MTORC1 phosphorylates ULK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672010

mTORC1 phosphorylates AKT1S1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672828

MARK3 phosphorylates KSR1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672948

MAP2Ks phosphorylate MAPKs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672973

RAF phosphorylates MAP2K dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672978

Activated MAPKs phosphorylate MAP2K1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5674496

Activated MAPK phosphorylates RAF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675194

Activated MAPKs phosphorylate BRAF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675198

ULK1 phosphorylates ATG13 and RB1CC1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675868

ULK1 phosphorylates Beclin-1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5679205

MRN bound to shortened telomeres activates ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682026

PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682101

ATM phosphorylates HERC2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682598

ATM phosphorylates WHSC1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682983

ATM phosphorylates TP53BP1 at DNA DSBs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683425

p-T68-CHEK2 autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683792

CHEK2 phosphorylates BRCA1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683801

ATM phosphorylates EYA1-4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683964

CDK2 phosphorylates RBBP8
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684096

ATM phosphorylates RBBP8
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684140

Activation of CHEK1 at resected DNA DSBs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684887

ATR phosphorylates RPA2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5685156

CHEK1 phosphorylates RAD51
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5685230

CHEK1 phosphorylates BRCA2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5685242

Activated ATM phosphorylates ABL1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686578

Activated ATM phosphorylates DCLRE1C
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686704

PAK1,2,3 phosphorylates MAPK6,4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687086

p-S MAPK6 phosphorylates NCOA3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687090

p-S MAPK6,4 phosphorylate MAPKAPK5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687094

p-T182 MAPKAPK5 phosphorylates FOXO3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687101

p-S MAPKAPK5 phosphorylates HSPB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687121

PRKDC phosphorylates DCLRE1C at DNA DSBs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687183

p-T182-MAPKAPK5 phoshphorylates DNAJB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690250

MAPKAPK5 phosphorylates KALRN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692768

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692775

p-T182 MAPKAPK5 phosphorylates FOXO1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692779

ATM phosphorylates MDC1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693536

MRN activates ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693540

ATM phosphorylates histone H2AFX on S139 at DNA DSBs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693549

Phosphorylation of BRCA1-A complex at multiple sites by ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693551

DNA-PKcs autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693575

ATM phosphorylates NBN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693598

ATM phosphorylates TP53 at S15
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693609

CSNK1D phosphorylates SEC23
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694441

ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6788392

TORC2 complex phosphorylates SGK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6795290

SGK1 phosphorylates MDM2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6795460

PDPK1 phosphorylates SGK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6795473

ATM phosphorylates DYRK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6798372

DYRK2 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6798374

ATM phosphorylates ZNF420
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799097

CHEK1 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799246

ATR phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799332

HIPK2 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799409

ATM phosphorylates PIDD1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800490

PLK2 phosphorylates CENPJ
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801666

PLK2 phosphorylates NPM1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801675

High kinase activity BRAF complexes phosphorylate MAP2Ks
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802911

RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802919

Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802926

p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802933

MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802935

RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802943

PLK3 phosphorylates CDC25C
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802973

CHEK2 phosphorylates TTC5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6804266

ATM phosphorylates TTC5
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6804276

ATM phosphorylates MDM2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6804955

CK2:FACT phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805059

AURKA phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805103

AURKB phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805126

CDK5 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805276

PLK3 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805285

TAF1 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805399

TP53RK phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805479

AKT phosphorylates KAT6A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805640

AKT phosphorylates PHF20
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805785

CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6810233

MAPKs phosphorylate PP2A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6811454

CK2 phosphorylates PDCL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6814409

Phosphorylation of Cdc25A at Ser-123 by Chk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69604

Phosphorylation of Cdc25A at Ser-123 by Chk2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69608

CHEK2 phosphorylates TP53
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69685

Phosphorylation and activation of CHEK2 by ATM
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69891

Phosphorylation of Cdc25C at Ser 216 by Chk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75010

Phosphorylation of Wee1 kinase by Chk1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75028

Phosphorylation of Cdc25C at Ser216 by CHEK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75809

Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75820

Phosphorylation (Ser5) of RNA pol II CTD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-77071

Casein kinase II phosphorylates PTEN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8850945

Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852306

PLK1 phosphorylates GTSE1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852317

TPX2 promotes AURKA autophosphorylation
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853419

AURKA phosphorylates PHLDA1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853444

PKA phosphorylates RET:GDNF:GFRA dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8854908

AAK1 phosphorylates AP-2 mu subunit at T156
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8856813

p25-bound CDK5 phosphorylates CDC25B
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863007

p25-bound CDK5 phosphorylates CDC25C
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863011

p25-bound CDK5 phosphorylates CDC25A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863014

IKKB phosphorylates SNAP23
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863895

MAPK12 phosphorylates PTPN3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868118

CDK5:p25 phosphorylates GOLGA2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868260

CDK5:p25 phosphorylates lamin B1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868340

CDK5:p25 phosphorylates lamin A
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868344

CDK5:p25 phosphorylates PRDX1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868567

CDK5:p25 phosphorylates PRDX2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868573

CDK5:p25 phosphorylates JUN
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8868666

CDK5:p25 phosphorylates FOXO3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8870558

Casein kinase II phosphorylates STARD10
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8873929

p-ULK1 phosphorylates DENND3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876446

MAP2K6 phosphorylates PIP4K2B
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877691

HIPK2 phosphorylates RUNX1 and EP300
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8878050

HIPK2 phosphorylates RUNX1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8878054

CK2 phosphorylates NFE2L2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8932322

Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8933446

Activated AKT phosphorylates RUNX2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8939963

CDK1 phosphorylates VCPIP1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940100

CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8942836

mTORC1 phosphorylates MAF1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8944454

FUNDC1 is phosphorylated by CK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948039

FUNDC1 is phosphorylated by ULK1 at Ser17
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948146

AKT phosphorylates MKRN1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948757

FAM20C phosphorylates FAM20C substrates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8952289

CHEK1 phosphorylates E2F6
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9007539

GSK3B phosphorylates RUNX2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9008480

PPM1D dephosphorylates RUNX2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9008822

Activated ERKs phosphorylate RUNX2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9009208

p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012319

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013978

HIPK2 phosphorylates MECP2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9022314

AURKB phosphorylates MECP2 at S423
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023132

Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032751

CDK5 phosphorylates NTRK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032863

ATR phosphorylates Histone H2A.X at unsynapsed regions
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-912470

PKA/PKG phosphorylate Rap1GAP2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-913996

Phosphorylation and release of IRF3/IRF7
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-918229

Phosphorylation and release of IRF7
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-933525

SPRY2 is phosphorylated by phosphorylated MNK1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-934559

Activation of TAK1 complex bound to activated TLR4 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936951

IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-937022

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-937059

AKT1 phosphorylates NOTCH4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604328

Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9610153

MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9610156

BRAF autophosphorylates downstream of RAP1 and NGF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9610163

SGK phosphorylates CREB1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9612501

SGK phosphorylates SRF
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9612509

BRAF in Rap1-GTP complex:BRAF complex autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9612980

PRKAA2 phosphorylates PLINs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9613530

AMPK phosphorylates MAPT
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619515

ERKs phosphorylate RSKs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619843

RSKs autophosphorylate
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9620004

AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624526

MAPK11 or MAPK14 phosphorylates NCF1 at Ser345
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9626880

CASP9 is phosphorylated at T412
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9627089

CDKN1B is phosphorylated in response to estrogen
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9632868

p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9633008

EIF2AK4 (GCN2) dimer autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9633742

LINC01139 promotes phosphorylation of HIF1A by LRRK2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9634702

ALPK1 phosphorylates TIFA
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645535

NEK6 and NEK7 phosphorylate EML4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9648089

p-T-EIF2AK1:ferriheme dimer autophosphorylates
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9648883

p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9648888

MAP2K mutants constitutively phosphorylate MAPKs
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9652165

KRAS4B is phosphorylated on serine 181
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9653503

MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9656214

RAF1 mutant complexes phosphorylate MAP2K dimer
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9656215

PLK2, MAPK14 phosphorylate ADAM17
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9662823

Unknown kinase phosphorylates p-DVL
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673346

GSK3 phosphorylates Nucleoprotein
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9683664

AKT phosphorylates FOXO3 downstream of FLT3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9699579

TBK1, IKBKE are autophosphorylated at Ser172
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9705320

Phosphorylation of TBK1/IKBKE
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9705323

MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9725030

GSK3 phosphorylates nucleoprotein
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729260

Unknown kinase phosphorylates nucleoprotein
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729300

CSNK1A1 phosphorylates nucleoprotein
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729318

MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9731111

JAK2-activated MAPKs phosphorylate YBX1
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9734547

Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975125

Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975134

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975160

IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975170

First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975180

Unknown kinase phosphorylates 9b
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9758486

Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975853

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975861

IRAK4 autophosphorylation within the complex activated TLR:MyD88
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975865

Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975874

First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975878

GSK3B phosphorylates p-NFE2L2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9762094

SQSTM1 oligomer is phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9766532

MAPK1,(MAPK3) phosphorylates NPAS4
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9769115

Active IKBKB phosphorylates NF-kappa-B inhibitor
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9773803

PRKAA2 phosphorylates nuclear NFE2L2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796067

EIF2AK3 phosphorylates NFE2L2
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796081

MAPKAPK2 phosphorylates RIPK1 at S320
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9815501

TBK1, IKBKE phosphorylate RIPK1 at T189
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9817397

CHUK, IKBKB phosphorylate RIPK1 at S25
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9818789

ULK1 phosphorylates RIPK1 at S357
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9819106

CK2 phosphorylates nascent P
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9831514

M dimer is phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9831712

p-S232-S237-P is further phosphorylated
type: Axiom
annotated source: GO_0004674
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9832782

GO_0004675
has db xref: Reactome:R-HSA-170868
has db xref: Reactome:R-HSA-198732
has db xref: Reactome:R-HSA-201476

Activated type I receptor phosphorylates SMAD2/3 directly
type: Axiom
annotated source: GO_0004675
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170868

STAT3 activation
type: Axiom
annotated source: GO_0004675
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198732

Activated type I receptor phosphorylates R-Smad1/5/8 directly
type: Axiom
annotated source: GO_0004675
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201476

GO_0004676
has db xref: Reactome:R-HSA-437195

PDPK1 activates PRKCZ
type: Axiom
annotated source: GO_0004676
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437195

GO_0004679
has db xref: Reactome:R-HSA-1592244
has db xref: Reactome:R-HSA-163691
has db xref: Reactome:R-HSA-200423
has db xref: Reactome:R-HSA-380927
has db xref: Reactome:R-HSA-447074
has db xref: Reactome:R-HSA-5673768
has db xref: Reactome:R-HSA-6805470

AMPK phosphorylates PPARGC1A
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1592244

Phosphorylation of ChREBP at Serine 556 by AMPK
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163691

pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200423

p-AMPK phosphorylates TSC1:TSC2
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380927

AMPK phosphorylates Raptor in the mTORC1 complex
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-447074

p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5673768

AMPK phosphorylates TP53
type: Axiom
annotated source: GO_0004679
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805470

GO_0004683
has db xref: Reactome:R-HSA-111912
has db xref: Reactome:R-HSA-111915
has db xref: Reactome:R-HSA-416320
has db xref: Reactome:R-HSA-442749
has db xref: Reactome:R-HSA-9006992
has db xref: Reactome:R-HSA-9617583
has db xref: Reactome:R-HSA-9618750
has db xref: Reactome:R-HSA-9619125
has db xref: Reactome:R-HSA-9619355
has db xref: Reactome:R-HSA-9619367
has db xref: Reactome:R-HSA-9619478
has db xref: Reactome:R-HSA-9619783

CaMK4 phosphorylates CREB1
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111912

CAMK4 autophosphorylates
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111915

Trafficking of GluR1-containing AMPA receptors
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416320

CaMKK autophosphorylates in the nucleus
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442749

MECP2 is phosphorylated at S423
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9006992

CaMKII autophosphorylates
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9617583

CaMKII phosphorylates AMPA receptor
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9618750

CaMKK phosphorylates CAMK4
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619125

CaMKK autophosphorylates in the cytosol
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619355

CaMKKs phosphorylate CAMK1
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619367

CAMKK2 phosphorylates AMPK
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619478

CAMK1 phosphorylates ARHGEF7-1
type: Axiom
annotated source: GO_0004683
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619783

GO_0004687
has db xref: Reactome:R-HSA-445813
has db xref: Reactome:R-HSA-5668978

Phosphorylation of Smooth Muscle Myosin Light Chains
type: Axiom
annotated source: GO_0004687
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445813

MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex
type: Axiom
annotated source: GO_0004687
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668978

GO_0004689
has db xref: Reactome:R-HSA-453337
has db xref: Reactome:R-HSA-71541
has db xref: Reactome:R-HSA-71588

glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP
type: Axiom
annotated source: GO_0004689
annotated property: hasDbXref
annotated target: Reactome:R-HSA-453337

glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
type: Axiom
annotated source: GO_0004689
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71541

glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP
type: Axiom
annotated source: GO_0004689
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71588

GO_0004691
has db xref: Reactome:R-HSA-163672
has db xref: Reactome:R-HSA-163676
has db xref: Reactome:R-HSA-163773
has db xref: Reactome:R-HSA-177275
has db xref: Reactome:R-HSA-177284
has db xref: Reactome:R-HSA-432232
has db xref: Reactome:R-HSA-5610717
has db xref: Reactome:R-HSA-5610720
has db xref: Reactome:R-HSA-5610741
has db xref: Reactome:R-HSA-5617179
has db xref: Reactome:R-HSA-5617182
has db xref: Reactome:R-HSA-5687088
has db xref: Reactome:R-HSA-913451
has db xref: Reactome:R-HSA-9838321

Phosphorylation of ChREBP at Thr(653) by PKA
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163672

Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163676

Phosphorylation of PF2K-Pase by PKA catalytic subunit
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163773

PKA phosphorylates DARPP-32 on Thr34
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177275

PKA phosphorylates PDE4B
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177284

Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432232

PKA phosphorylates GLI2
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610717

PKA phosphorylates GLI3
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610720

PKA phosphorylates GLI1
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610741

PRKACA phosphorylates TNNI3
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5617179

PRKACA phosphorylates PLN
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5617182

PKA phosphorylates MAPKAPK5
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687088

IL3RB is phosphorylated on Ser-585
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-913451

PRKACA phosphorylates TFAM in the mitochondrial matrix
type: Axiom
annotated source: GO_0004691
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9838321

GO_0004692
has db xref: Reactome:R-HSA-1475422
has db xref: Reactome:R-HSA-1497853
has db xref: Reactome:R-HSA-418442
has db xref: Reactome:R-HSA-418549

PTPS is phosphorylated by cGMP-dependant protein kinase II
type: Axiom
annotated source: GO_0004692
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475422

Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II
type: Axiom
annotated source: GO_0004692
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1497853

PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release
type: Axiom
annotated source: GO_0004692
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418442

PKG1 phosphorylates BK channels
type: Axiom
annotated source: GO_0004692
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418549

GO_0004693
has db xref: Reactome:R-HSA-1226094
has db xref: Reactome:R-HSA-1226095
has db xref: Reactome:R-HSA-174079
has db xref: Reactome:R-HSA-174122
has db xref: Reactome:R-HSA-174132
has db xref: Reactome:R-HSA-174251
has db xref: Reactome:R-HSA-180047
has db xref: Reactome:R-HSA-187520
has db xref: Reactome:R-HSA-187916
has db xref: Reactome:R-HSA-187948
has db xref: Reactome:R-HSA-187959
has db xref: Reactome:R-HSA-188390
has db xref: Reactome:R-HSA-1912391
has db xref: Reactome:R-HSA-2172183
has db xref: Reactome:R-HSA-2220971
has db xref: Reactome:R-HSA-2245218
has db xref: Reactome:R-HSA-2294600
has db xref: Reactome:R-HSA-2430533
has db xref: Reactome:R-HSA-2468287
has db xref: Reactome:R-HSA-2468293
has db xref: Reactome:R-HSA-2514854
has db xref: Reactome:R-HSA-2984220
has db xref: Reactome:R-HSA-2990882
has db xref: Reactome:R-HSA-3788705
has db xref: Reactome:R-HSA-380278
has db xref: Reactome:R-HSA-4086410
has db xref: Reactome:R-HSA-4088024
has db xref: Reactome:R-HSA-5195402
has db xref: Reactome:R-HSA-5244669
has db xref: Reactome:R-HSA-5692755
has db xref: Reactome:R-HSA-6793661
has db xref: Reactome:R-HSA-6797606
has db xref: Reactome:R-HSA-6805109
has db xref: Reactome:R-HSA-68944
has db xref: Reactome:R-HSA-69005
has db xref: Reactome:R-HSA-69227
has db xref: Reactome:R-HSA-69754
has db xref: Reactome:R-HSA-69756
has db xref: Reactome:R-HSA-9008412
has db xref: Reactome:R-HSA-9009282
has db xref: Reactome:R-HSA-9624800
has db xref: Reactome:R-HSA-9686521

Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1226094

Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1226095

Phosphorylation of Cdh1 by Cyclin A:Cdk2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174079

Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174122

Free APC/C phosphorylated by Cyclin B:Cdc2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174132

Phosphorylation of Cdh1 by Cyclin B1:Cdc2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174251

CDK5 phosphorylates DARPP-32 on Thr75
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180047

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187520

Cyclin A:Cdk2 mediated phosphorylation of p27/p21
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187916

Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187948

Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187959

Cyclin E:CDK2-mediated phosphorylation of RB1
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-188390

NICD1 is phosphorylated by CDK8
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912391

Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2172183

CDK8 phosphorylates NICD1 PEST domain mutants
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2220971

CDK1 phosphorylates PHF8
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2245218

CDK1 phosphorylates condensin II subunit NCAPD3
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2294600

CDK1 phosphorylates MASTL
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2430533

CDK1 phosphorylates CDCA5 (Sororin) at centromeres
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2468287

CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2468293

CDK1 phosphorylates condensin I
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514854

CDK1:CCNB phosphorylates NEK9
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2984220

CDK1 phosphorylates NUP98
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2990882

CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3788705

CCNB1:p-T160-CDK1 phosphorylates NUMA1
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380278

CDK1 phosphorylates BORA
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4086410

CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4088024

CDK1 phosphorylates LPIN
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5195402

CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5244669

CDK1 phosphorylates MAPK6
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692755

(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6793661

CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6797606

CDK2 phosphorylates TP53
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6805109

Orc1 is phosphorylated by cyclin A/CDK2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68944

Cdc6 protein is phosphorylated by CDK
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69005

Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69227

Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69754

Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69756

CDK4 phosphorylates RUNX2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9008412

CDK1 phosphorylates RUNX2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9009282

CDK1 phosphorylates LBR
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624800

CDK2:CCNA phosphorylates TERF2
type: Axiom
annotated source: GO_0004693
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686521

GO_0004697
has db xref: Reactome:R-HSA-1433508
has db xref: Reactome:R-HSA-193703
has db xref: Reactome:R-HSA-198314
has db xref: Reactome:R-HSA-2179413
has db xref: Reactome:R-HSA-2730863
has db xref: Reactome:R-HSA-374664
has db xref: Reactome:R-HSA-429698
has db xref: Reactome:R-HSA-450533
has db xref: Reactome:R-HSA-450550
has db xref: Reactome:R-HSA-5138432
has db xref: Reactome:R-HSA-5218805
has db xref: Reactome:R-HSA-5218823
has db xref: Reactome:R-HSA-5229194
has db xref: Reactome:R-HSA-5623667
has db xref: Reactome:R-HSA-5625784
has db xref: Reactome:R-HSA-5671749
has db xref: Reactome:R-HSA-74615
has db xref: Reactome:R-HSA-751040
has db xref: Reactome:R-HSA-8932284
has db xref: Reactome:R-HSA-8934446
has db xref: Reactome:R-HSA-9010681
has db xref: Reactome:R-HSA-9021357
has db xref: Reactome:R-HSA-909552
has db xref: Reactome:R-HSA-927889
has db xref: Reactome:R-HSA-9626817
has db xref: Reactome:R-HSA-9632858
has db xref: Reactome:R-HSA-9796053

PKC alpha interacts with and phosphorylates KIT
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433508

IKKbeta is activated
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193703

DAG stimulates protein kinase C-delta
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198314

Activated PKC-alpha activate MMP3
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2179413

Phosphorylation of CARMA1 by PKC-theta
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730863

Phosphorylation and activation of Ezrin
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374664

PRKD1,2,3 phosphorylates CERT1-2
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429698

PKCdelta phosphorylates HuR
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450533

PKCalpha phosphorylates HuR
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450550

DVL2 is phosphorylated by PKC
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5138432

PKC autophosphorylates
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218805

PKC phosphorylates sphingosine kinase 1
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218823

Depolymerization of lamin filaments after PKC-mediated phosphorylation
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5229194

PDPK1 phosphorylates PKN1,2,3
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623667

PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5625784

p-T774-PKN1 phosphorylates CDC25C
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5671749

PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74615

PKC phosphorylates G alpha (z)
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-751040

PKC phosphorylates NFE2L2
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8932284

Activated PKC phosphorylates SHC1
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8934446

PKC phosphorylates ROBO3.1
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9010681

PRKCI phosphorylates ELF3
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9021357

Phosphorylation of STAT1 at Ser727
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909552

SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-927889

PKC phosphorylates NCF1
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9626817

PRKCZ autophosphorylates downstream of estrogen stimulation
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9632858

PRKCI phosphorylates NFE2L2
type: Axiom
annotated source: GO_0004697
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796053

GO_0004698
has db xref: Reactome:R-HSA-114683
has db xref: Reactome:R-HSA-114684
has db xref: Reactome:R-HSA-416639
has db xref: Reactome:R-HSA-421007
has db xref: Reactome:R-HSA-8986937
has db xref: Reactome:R-HSA-9005561

Phosphorylation of Platelet Sec-1
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114683

Phosphorylation of Syntaxin-4
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114684

Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416639

Endocytosis of Ca impermeable AMPA receptors
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-421007

MECP2 is phosphorylated at T308
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986937

Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308
type: Axiom
annotated source: GO_0004698
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9005561

GO_0004699
has db xref: Reactome:R-HSA-5607740

PKC-delta phosphorylates CARD9
type: Axiom
annotated source: GO_0004699
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607740

GO_0004705
has db xref: Reactome:R-HSA-168136
has db xref: Reactome:R-HSA-204949
has db xref: Reactome:R-HSA-205075
has db xref: Reactome:R-HSA-205132
has db xref: Reactome:R-HSA-9673789

Activated JNKs phosphorylate c-JUN
type: Axiom
annotated source: GO_0004705
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168136

NRIF and TRAF6 may activate JNK
type: Axiom
annotated source: GO_0004705
annotated property: hasDbXref
annotated target: Reactome:R-HSA-204949

JNK phosphorylates BIM, BAD and other targets
type: Axiom
annotated source: GO_0004705
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205075

NRAGE activates JNK
type: Axiom
annotated source: GO_0004705
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205132

Activated JNK phosphorylates c-JUN
type: Axiom
annotated source: GO_0004705
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673789

GO_0004707
has db xref: Reactome:R-HSA-111898
has db xref: Reactome:R-HSA-198733
has db xref: Reactome:R-HSA-445079
has db xref: Reactome:R-HSA-451366
has db xref: Reactome:R-HSA-5654560
has db xref: Reactome:R-HSA-5654562
has db xref: Reactome:R-HSA-5654565
has db xref: Reactome:R-HSA-5654566
has db xref: Reactome:R-HSA-73722
has db xref: Reactome:R-HSA-9626832

Phosphorylation of cPLA2 by ERK-2
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111898

ERK5 is activated
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198733

Phosphorylation of L1 by ERK
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445079

Activation of p38MAPK by DSCAM
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451366

Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654560

Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654562

Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654565

Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654566

Phosphorylation of UBF-1:rDNA Promoter
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73722

MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
type: Axiom
annotated source: GO_0004707
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9626832

GO_0004708
has db xref: Reactome:R-HSA-1247960
has db xref: Reactome:R-HSA-3238999
has db xref: Reactome:R-HSA-448951
has db xref: Reactome:R-HSA-450333
has db xref: Reactome:R-HSA-5218804

Activation of p38 MAPK
type: Axiom
annotated source: GO_0004708
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1247960

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5
type: Axiom
annotated source: GO_0004708
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3238999

Activation of p38 alpha/beta MAPK
type: Axiom
annotated source: GO_0004708
annotated property: hasDbXref
annotated target: Reactome:R-HSA-448951

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
type: Axiom
annotated source: GO_0004708
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450333

p38 MAPK activation by VEGFR
type: Axiom
annotated source: GO_0004708
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218804

GO_0004709
has db xref: Reactome:R-HSA-2730887
has db xref: Reactome:R-HSA-392530
has db xref: Reactome:R-HSA-451649
has db xref: Reactome:R-HSA-727819
has db xref: Reactome:R-HSA-933530

Autophosphorylation and activation of MEKK1
type: Axiom
annotated source: GO_0004709
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730887

p-S400-Cot phosphorylates NIK
type: Axiom
annotated source: GO_0004709
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392530

TPL2 phosphorylates MEK1, SEK1
type: Axiom
annotated source: GO_0004709
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451649

TAK1 phosphorylates MKK6
type: Axiom
annotated source: GO_0004709
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727819

Activation of IKK by MEKK1
type: Axiom
annotated source: GO_0004709
annotated property: hasDbXref
annotated target: Reactome:R-HSA-933530

GO_0004712
has db xref: Reactome:R-HSA-5672969
has db xref: Reactome:R-HSA-5674373
has db xref: Reactome:R-HSA-6802910
has db xref: Reactome:R-HSA-6802916
has db xref: Reactome:R-HSA-6802918
has db xref: Reactome:R-HSA-6802921
has db xref: Reactome:R-HSA-6802922
has db xref: Reactome:R-HSA-6802924
has db xref: Reactome:R-HSA-6802927
has db xref: Reactome:R-HSA-6802941
has db xref: Reactome:R-HSA-9656212

Phosphorylation of RAF
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672969

MAP2Ks phosphorylate MAPK at the Golgi membrane
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5674373

Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802910

RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802916

Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802918

Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802921

Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802922

RAF is phosphorylated downstream of oncogenic RAS
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802924

BRAF and RAF fusion mutant dimers are phosphorylated
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802927

RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6802941

Phosphorylation of RAF1 mutants
type: Axiom
annotated source: GO_0004712
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9656212

GO_0004713
has db xref: Reactome:R-HSA-112333
has db xref: Reactome:R-HSA-114600
has db xref: Reactome:R-HSA-1168394
has db xref: Reactome:R-HSA-1169421
has db xref: Reactome:R-HSA-1225952
has db xref: Reactome:R-HSA-1225960
has db xref: Reactome:R-HSA-1247844
has db xref: Reactome:R-HSA-1248655
has db xref: Reactome:R-HSA-1248694
has db xref: Reactome:R-HSA-1250195
has db xref: Reactome:R-HSA-1250315
has db xref: Reactome:R-HSA-1250348
has db xref: Reactome:R-HSA-1251922
has db xref: Reactome:R-HSA-1295540
has db xref: Reactome:R-HSA-1295609
has db xref: Reactome:R-HSA-1307963
has db xref: Reactome:R-HSA-1433418
has db xref: Reactome:R-HSA-1433454
has db xref: Reactome:R-HSA-1433488
has db xref: Reactome:R-HSA-1433506
has db xref: Reactome:R-HSA-1433542
has db xref: Reactome:R-HSA-1470009
has db xref: Reactome:R-HSA-1472121
has db xref: Reactome:R-HSA-1524186
has db xref: Reactome:R-HSA-1671691
has db xref: Reactome:R-HSA-170070
has db xref: Reactome:R-HSA-170156
has db xref: Reactome:R-HSA-170991
has db xref: Reactome:R-HSA-171011
has db xref: Reactome:R-HSA-174164
has db xref: Reactome:R-HSA-177934
has db xref: Reactome:R-HSA-177937
has db xref: Reactome:R-HSA-182969
has db xref: Reactome:R-HSA-183058
has db xref: Reactome:R-HSA-1839065
has db xref: Reactome:R-HSA-1839067
has db xref: Reactome:R-HSA-1839098
has db xref: Reactome:R-HSA-1839110
has db xref: Reactome:R-HSA-1839112
has db xref: Reactome:R-HSA-186786
has db xref: Reactome:R-HSA-1888198
has db xref: Reactome:R-HSA-190326
has db xref: Reactome:R-HSA-190385
has db xref: Reactome:R-HSA-190388
has db xref: Reactome:R-HSA-190408
has db xref: Reactome:R-HSA-190413
has db xref: Reactome:R-HSA-190427
has db xref: Reactome:R-HSA-190429
has db xref: Reactome:R-HSA-191062
has db xref: Reactome:R-HSA-191636
has db xref: Reactome:R-HSA-1963581
has db xref: Reactome:R-HSA-1963582
has db xref: Reactome:R-HSA-1963586
has db xref: Reactome:R-HSA-1982066
has db xref: Reactome:R-HSA-2012073
has db xref: Reactome:R-HSA-2012082
has db xref: Reactome:R-HSA-2012087
has db xref: Reactome:R-HSA-201521
has db xref: Reactome:R-HSA-202165
has db xref: Reactome:R-HSA-202168
has db xref: Reactome:R-HSA-202174
has db xref: Reactome:R-HSA-202216
has db xref: Reactome:R-HSA-202233
has db xref: Reactome:R-HSA-202245
has db xref: Reactome:R-HSA-202248
has db xref: Reactome:R-HSA-202291
has db xref: Reactome:R-HSA-202307
has db xref: Reactome:R-HSA-2023455
has db xref: Reactome:R-HSA-2023460
has db xref: Reactome:R-HSA-2029268
has db xref: Reactome:R-HSA-2029449
has db xref: Reactome:R-HSA-2029453
has db xref: Reactome:R-HSA-2029459
has db xref: Reactome:R-HSA-2029984
has db xref: Reactome:R-HSA-2029989
has db xref: Reactome:R-HSA-2033485
has db xref: Reactome:R-HSA-2033486
has db xref: Reactome:R-HSA-2033488
has db xref: Reactome:R-HSA-2033490
has db xref: Reactome:R-HSA-2038387

SRC autophosphorylation is positively regulated by InlA-bound CDH1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112333

Fyn/Lyn-mediated phosphorylation of FcR1 gamma
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114600

STAT5 tyrosine phosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168394

Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169421

Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1225952

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1225960

Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1247844

Trans-autophosphorylation of EGFRvIII mutant dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1248655

Trans-autophosphorylation of ERBB2 homodimer
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1248694

SHC1 phosphorylation by ERBB2 heterodimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250195

Trans-autophosphorylation of ERBB4 homodimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250315

Phosphorylation of SHC1 by ERBB4 homodimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250348

PLCG1 phosphorylation by p-EGFR:p-ERBB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1251922

IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1295540

SRC phosphorylates SPRY2 on Y55 and Y227
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1295609

Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1307963

Phosphorylation of JAK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433418

Phosphorylation of GAB2 by SFKs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433454

Phosphorylation of SHP2 by SFKs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433488

Phosphorylation of APS
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433506

Phosphorylation and activation of VAV1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433542

Phosphorylation of STATs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1470009

Phosphorylation of p-KIT on Y900 by Src kinases
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1472121

Phosphorylation of PLCgamma by PDGFR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1524186

PRLR-bound STAT5 is phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1671691

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170070

Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170156

SRC-1 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170991

Binding and activation of MAP Kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-171011

Phosphorylation of Cyclin A:Cdk2 at Tyr 15
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174164

EGFR autophosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177934

Phosphorylation of EGFR by SRC kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177937

Phosphorylation of CBL (EGFR:CBL)
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-182969

Phosphorylation of CBL (EGFR:GRB2:CBL)
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183058

Phosphorylation of cytosolic FGFR1 fusion dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1839065

Phosphorylation of BCR moiety of BCR-FGFR1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1839067

Activated FGFR1 mutants and fusions phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1839098

p-BCR-p-FGFR1 phosphorylates GAB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1839110

Phosphorylation of STAT5 by cytosolic FGFR1 fusions
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1839112

Autophosphorylation of PDGF beta receptors
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-186786

FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1888198

Autocatalytic phosphorylation of FGFR4
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190326

Autocatalytic phosphorylation of FGFR3b
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190385

Autocatalytic phosphorylation of FGFR3c
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190388

Autocatalytic phosphorylation of FGFR2b
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190408

Autocatalytic phosphorylation of FGFR2c
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190413

Autocatalytic phosphorylation of FGFR1b
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190427

Autocatalytic phosphorylation of FGFR1c
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190429

Autocatalytic phosphorylation of Klotho-bound FGFR1c
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191062

Phosphorylation of Cx43 by c-src
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191636

Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1963581

Trans-autophosphorylation of ERBB2 heterodimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1963582

SRC family kinases phosphorylate ERBB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1963586

Ligand-independent phosphorylation of overexpressed FGFR1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1982066

Autocatalytic phosphorylation of FGFR3c P250R mutant
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2012073

Autocatalytic phosphorylation of FGFR3 cysteine mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2012082

Autocatalytic phosphorylation of FGFR4 Y367C mutant
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2012087

ALK autophosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201521

Phosphorylation of ITAM motifs in CD3 complexes
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202165

Phosphorylation of ZAP-70 by Lck
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202168

Activation of ZAP-70
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202174

Phosphorylation of SLP-76
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202216

Inactivation of Lck by Csk
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202233

Phosphorylation of TBSMs in LAT
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202245

Phosphorylation of PLC-gamma1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202248

Activation of Lck
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202291

Change of PKC theta conformation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202307

Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2023455

Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2023460

Phosphorylation and activation of PLCG
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029268

Phosphorylation of SYK by Src kinases
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029449

Phosphorylation of VAV
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029453

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029459

Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029984

Autocatalytic phosphorylation of overexpressed FGFR2 variants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029989

Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2033485

Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2033486

Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2033488

Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2033490

Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2038387

Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2038944

Autophosphorylation of KIT
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205289

Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210291

Trans-phosphorylation of Tie2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210872

EGFR activates PLC-gamma1 by phosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212710

ABL phosphorylates WAVEs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2130194

Src phosphorylate WASP,N-WASP
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2197698

TIRAP is phosphorylated by BTK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2201322

Phosphorylation of SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2395412

Phosphorylation of DAP12
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2395439

Phosphorylation of LAT by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2395801

Phosphorylation of SLP-76 by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2396594

IGF1R phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2404193

IGF1,2:IGF1R autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2404199

Phosphorylation of BTK by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424484

Phosphorylation and activation of VAV2/VAV3 by SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424486

Phosphorylation of PLC-gamma by p-BTK/p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424487

IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2428926

Phosphorylation of beta and gamma subunits by LYN
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2454208

Phosphorylation of SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2454239

JAK2 Phosphorylates LEPR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2586553

JAK2 Autophosphorylates in Response to Leptin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2586555

JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2671742

JAK2 Phosphorylates STAT5 in Response to Leptin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2671829

JAK2 Phosphoryates STAT3 in Response to Leptin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2671850

Phosphorylation of TEC kinases by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730833

Phosphorylation of LAT by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730843

Phosphorylation of SLP-76 by p-SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730851

Autophosphorylation of BTK/ITK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730858

Phosphorylation of GAB2 by SYK/FYN
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730860

Autophosphorylation of LYN kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730862

Phosphorylation of PKC-theta
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730882

Phosphorylation of NTAL by p-SYK/Lyn
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730884

Phosphorylation of SHC by SYK kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730886

Phosphorylation of PLC-gamma
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730888

PRMT5 is tyrosine phosphorylated by JAK2 V617F
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3215391

Autophosphorylation of PTK2 at Y397
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-354073

Phosphorylation of pPTK2 by SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-354124

Phosphorylation of BCAR1 by SRC-PTK2 complex
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372693

Phosphorylation of nephrin by FYN
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-373747

SEMA4D interacts with Plexin-B1:ErbB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-373750

Phosphorylation of DCC by Fyn
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374701

Autophosphorylation of SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-377640

Activation of Src
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380780

Phosphorylation of CD28
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-388831

Phosphorylation of CTLA-4
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-388833

Autophosphorylation of PDGF alpha receptors
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389083

Autophosphorylation of PDGF alpha/beta receptors
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389086

CSF1R trans-autophosphorylates on multiple tyrosine and serine residues
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389159

Activation of Vav1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389354

Phosphorylation of PD-1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389762

Phosphorylation of ITIM motif in SIRP alpha
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-391156

Recruitment of FAK to NCAM1:Fyn in lipid rafts
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-391865

Phosphorylation of FAK by Src kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-391866

Autophosphorylation of NCAM1 bound Fyn
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-391871

EPH receptors autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928578

SFKs phosphorylate EFNBs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928580

FYN phosphorylates NMDAR2B
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928583

SFKs phosphorylate GIT1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928594

SFKs phosphorylate VAV2,3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928604

PTK2 autophosphorylates at Y397
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928610

EPHB phosphorylates TIAM1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928627

SFKs phosphorylate NGEF
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928648

Phosphorylation of Plexin-A
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399934

Recruitment and activation of Cdk5
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399946

Tyrosine phosphorylation of CRMPs by Fes
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399947

p-EPHB phosphorylates SDC2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4093332

Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418163

Phosphorylation of Unc5C
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418859

Phosphorylation of FADK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418872

SEMA4D interacts with Plexin-B1:Met
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419646

Phosphorylation of ROBO1 by ABL kinase
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428888

SYK activation by SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429441

Syk activation leads to SLP-76 activation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429449

FGR binds and phosphorylates LRP8
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432129

Syk/Lck phosphorylate LAT
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-434836

VEGFR2 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4420117

SFKs phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4420121

SRC-1 phosphorylates SHB
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4420128

Phosphorylation of SRC-1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4420206

Phosphorylation of L1 by EPHB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-443817

Phosphorylation of Y1229 in L1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445076

Phosphorylation of L1 by SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445084

Phosphorylation of VAV2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445085

Phosphorylation of Neurofascin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445091

Within the IL-2R complex JAK3 phosphorylates JAK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451942

Recruited STAT5 is phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-452097

SHC1 bound to IL2 receptor is phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-452100

JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-452122

SYK is a substrate for JAK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508282

SRC-1 phosphorylates p-Y397-PTK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218640

PTK2 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218642

FYN autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218806

PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218809

FYN phosphorylates PAK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218812

Src kinases phosphorylate VAV
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218820

PTK2/SRC-1 phosphorylates BCAR1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218828

SRC-1 phosphorylates PTK2-beta
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218830

p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218851

AXL autophosphorylates on Y779 and Y821
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357429

1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607745

SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607750

LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621355

SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621363

SYK autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5621370

SFKs phosphorylates RAF1 on Y340,Y341
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5624486

Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5637795

Phosphorylation of SHC1 by p-5Y-EGFRvIII
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5637796

Activated FGFR2 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654147

Activated FGFR1 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654149

Activated FGFR4 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654151

Activated FGFR3 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654222

Activated FGFR2 phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654397

Activated FGFR2 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654407

Activated FGFR3 phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654408

Activated FGFR4 phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654418

Activated FGFR4 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654428

Ligand-independent phosphorylation of overexpressed FGFR1c
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654545

Activated FGFR1 phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654575

Activated FGFR1 phosphorylates FRS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654578

Activated FGFR1 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654582

Activated FGFR1:p-FRS phosphorylates PPTN11
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654587

Activated FGFR2 phosphorylates FRS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654605

Activated FGFR2 phosphorylates PPTN11
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654607

Activated FGFR3 phosphorylates FRS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654628

Activated FGFR3 phosphorylates PPTN11
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654631

Activated FGFR3 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654634

Activated FGFR4 phosphorylates FRS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654653

Activated FGFR4 phosphorylates PPTN11
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654655

Activated FGFR3 point and translocation mutants phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655243

Activated FGFR2 mutants phosphorylate FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655268

Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655270

Activated FGFR1 mutants phosphorylate FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655278

Activated FGFR4 mutants phosphorylate FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655284

Activated FGFR2 mutants phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655301

Activated FGFR4 mutants phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655341

WICH phosphorylates H2AFX on Y142
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683930

ABL1 phosphorylates RAD52
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686587

LYN phosphorylates CD22
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690702

STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784006

JAK1,TYK2 phosphorylate JAK1,TYK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784319

HVEM induses BTLA phosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6790087

MET dimers autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6806974

Mcm2-7 is phosphorylated by DDK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68954

Phosphorylation of Cyclin E:CDK2 complexes by WEE1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69195

Transphosphorylation of JAK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-873918

Phosphorylation of JAK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-873919

Phosphorylation of STAT1 by JAK kinases
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-873922

Phosphorylation of IFNGR1 by JAK kinases
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-873924

Tyrosine kinases phosphorylate the receptor
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-879907

Activation of STAT5a/b by JAK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-879909

SHC1 bound to the common beta chain becomes tyrosine phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-879925

FRK phosphorylates PTEN
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8847977

ERBB2 promotes PTK6 autophosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848005

PTK6 phosphorylates STAP2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848077

PTK6 phosphorylates STAT3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848124

PTK6 phosphorylates CDKN1B
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848436

PTK6 phosphorylates PXN
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848606

PTK6 phosphorylates BCAR1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848726

PTK6 phosphorylates AKT1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848758

PTK6 phosphorylates DOK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848776

PTK6 phosphorylates CBL
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848818

PTK6 phosphorylates ARAP1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848873

PTK6 phosphorylates KHDRBS1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848975

PTK6 phosphorylates KHDRBS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849032

PTK6 phosphorylates KHDRBS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849042

PTK6 phosphorylates ARHGAP35
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849068

SRMS phosphorylates PTK6
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849102

PTK6 phosphorylates SFPQ
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849463

MET phosphorylates SHC1-2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851890

MET phosphorylates GAB1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851933

Autocatalytic phosphorylation of FGFR3 fusions
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853309

FGFR2 fusions autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853313

Plasma membrane FGFR1 fusions autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853325

FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855237

EGFR phosphorylates GPNMB
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8857555

LINC01139 facilitates PTK6 autophosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8857577

LINC01139 promotes phosphorylation of HIF1A by PTK6
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8857583

Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8857925

EGFR phosphorylates EPS15
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8867041

PTK2 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874078

SRC phosphorylates PTK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874080

MET phosphorylates PTK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8874082

MET phosphorylates CBL
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875451

MET phosphorylates STAT3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875817

InlB:MET dimer trans-autophophorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876230

InlB-activated MET phosphorylates CBL
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876246

SRC phosphorylates InlA-bound CDH1 and CTNNB1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876948

SRC phosphorylates RUNX1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8937728

SRC phosphorylates RUNX3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8937807

SRC,YES1 phosphorylate YAP1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8937844

Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8942607

p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948143

ABL1 phosphorylates YAP1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8956659

G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8964242

G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8964252

JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983872

Phospho-JAK2 phosphorylates EPOR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9006323

JAK2 transphosphorylates and is activated in response to Erythropoietin
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9006332

SRC phosphorylates ROBO3.1 in response to NTN1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9011241

JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012650

EGFR phosphorylates NOTCH3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018572

ESR-associated SRC autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9021609

LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9024726

BDNF-bound NTRK2 dimers trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026464

NTF3-bound NTRK2 dimers trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026502

NTF4-bound NTRK2 dimers trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026510

NTRK2 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026579

NTRK2 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026890

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027272

JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027273

LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9027425

NTRK2 phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9028728

JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9029151

JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9029155

NTRK2 phosphorylates FRS3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032426

NTRK2-bound FYN autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032532

FYN-mediated phosphorylation of GRIN2B
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032601

NTRK2 phosphorylates CDK5
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032854

NTRK2 promotes TIAM1 phosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033284

NTRK3 dimers trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9034714

NTRK3 phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9034814

NTRK3 phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9034875

SRC,FYN phosphorylate NTRK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9037040

Formation of p-STAT1 homodimer
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909718

Phosphorylation of STAT1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909726

Activation of JAK kinases
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909729

Phosphorylation of INFAR1 by TYK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909730

Phosphorylation of STAT2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-909732

CBL is tyrosine phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-912629

Activated NTRK3 promotes SRC autophosphorylation
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603420

FLT3LG dimer:FLT3 dimer autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604767

BTK autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9606159

Phosphorylated BTK phosphorylates PLCG2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9606162

p-SYK and LYN phosphorylate BTK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9606163

SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9612085

NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9612996

NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9613023

SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624014

PTK2 autophosphorylates downstream of EGFR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9625487

ERBB2 homodimer phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9634390

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664261

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664275

Phosphorylation and activation of PLCG due to FCGR3A effect
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664278

ERBB2 KD mutants trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664588

Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664976

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665032

Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665389

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665411

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665704

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665705

ERBB2 TMD/JMD heterodimers trans-autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665709

p-6Y-SYK phosphorylates VAV1,2,3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9666425

Constitutive phosphorylation of kinase domain KIT mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9669890

Phosphorylation of juxtamembrane domain KIT mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9669911

Phosphorylation of STATs downstream of KIT mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9670412

Phosphorylation of JAK2 downstream of KIT mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9670418

Autophosphorylation of PDGFRA extracellular domain dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9672173

Autophosphorylation of PDGFR mutant dimers
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9672175

Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673756

Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673761

p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9674558

p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9674567

Phosphorylation of extracellular domain KIT mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9680248

Constitutive phosphorylation of FLT3 mutants
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9695834

FLT3 mutants phosphorylate GAB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698003

FLT3 ITD mutants phosphorylate STAT5
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698005

Active FLT3 phosphorylates CDKN1B
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9699578

Active ALK phosphorylates FRS2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700164

Active ALK phosphorylates IRS1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700168

Active ALK phosphorylates PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700171

Active ALK phosphorylates SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700175

Autophosphorylation of ALK fusions
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700181

Autophosphorylation of point mutants of ALK
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700186

ALK mutants phosphorylate SHC1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700193

Active ALK phosphorylates SRC
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700647

Active ALK phosphorylates JAK3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9701488

FLT3 fusion dimers autophosphorylate
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9703437

FLT3 fusions phosphorylate GAB2
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9703438

FLT3 phosphorylates GRB10
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9706344

FLT3 phosphorylates CBL
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9706350

PTK6 phosphorylates STAT3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9709918

ALK fusions phosphorylate IRS1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712082

ALK mutants phosphorylate STAT3
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712085

ALK fusions phosphorylate PLCG1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712086

ALK fusions phosphorylate FRS
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712087

SRC phosphorylates RHOU
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9726848

JAK1-mediated phosphorylation of RAF1
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9732738

CSF1R trans-autophosphorylates on tyrosine-561
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9733314

Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9733323

BACH1 is phosphorylated at tyrosine 483
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9762209

JAK2 phosphorylation of GHR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-982807

SH pentamer is phosphorylated
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9831136

p-6Y-SYK phosphorylates BLNK (SLP65)
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983703

SYK autophosphorylates at the activated BCR
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983707

LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
type: Axiom
annotated source: GO_0004713
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983709

GO_0004714
has db xref: Reactome:R-HSA-166544
has db xref: Reactome:R-HSA-167019
has db xref: Reactome:R-HSA-167683
has db xref: Reactome:R-HSA-169905
has db xref: Reactome:R-HSA-177930
has db xref: Reactome:R-HSA-177933
has db xref: Reactome:R-HSA-198295
has db xref: Reactome:R-HSA-6784324
has db xref: Reactome:R-HSA-74711
has db xref: Reactome:R-HSA-74742
has db xref: Reactome:R-HSA-8852552
has db xref: Reactome:R-HSA-8853792
has db xref: Reactome:R-HSA-8950269
has db xref: Reactome:R-HSA-8950340
has db xref: Reactome:R-HSA-8950354
has db xref: Reactome:R-HSA-8950364
has db xref: Reactome:R-HSA-8950405
has db xref: Reactome:R-HSA-8950423
has db xref: Reactome:R-HSA-8950453
has db xref: Reactome:R-HSA-8950485
has db xref: Reactome:R-HSA-8950537
has db xref: Reactome:R-HSA-8950591
has db xref: Reactome:R-HSA-8950757
has db xref: Reactome:R-HSA-8982163
has db xref: Reactome:R-HSA-8983300
has db xref: Reactome:R-HSA-8983309
has db xref: Reactome:R-HSA-8983371
has db xref: Reactome:R-HSA-8983424
has db xref: Reactome:R-HSA-8986985
has db xref: Reactome:R-HSA-8986994
has db xref: Reactome:R-HSA-8986995
has db xref: Reactome:R-HSA-8987012
has db xref: Reactome:R-HSA-8987040
has db xref: Reactome:R-HSA-8987042
has db xref: Reactome:R-HSA-8987070
has db xref: Reactome:R-HSA-8987084
has db xref: Reactome:R-HSA-8987096
has db xref: Reactome:R-HSA-8987129
has db xref: Reactome:R-HSA-8987141
has db xref: Reactome:R-HSA-8987150
has db xref: Reactome:R-HSA-8987179
has db xref: Reactome:R-HSA-8987202
has db xref: Reactome:R-HSA-8987255

TrkA receptor autophosphorylates
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166544

SHC, complexed with TrkA, is tyrosine-phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167019

TrkA phosphorylates PLCG1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167683

ARMS is phosphorylated by active TrkA receptor
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169905

GAB1 phosphorylation by EGFR kinase
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177930

SHC1 phosphorylation by phosphorylated EGFR
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177933

TRKA phosphorylates IRS
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198295

p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6784324

Phosphorylation of IRS
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74711

Phosphorylation of SHC1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74742

MST1R autophosphorylates
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852552

RET tyrosine phosphorylation
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853792

STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950269

IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950340

STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950354

IL23R in IL23:IL23 receptor complex is phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950364

JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950405

JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950423

JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950453

STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950485

JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950537

JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950591

IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8950757

IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982163

IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983300

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983309

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983371

IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8983424

IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986985

IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986994

IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986995

IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987012

IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987040

IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987042

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987070

IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987084

IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987096

JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987129

IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987141

IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987150

IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987179

IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987202

IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3
type: Axiom
annotated source: GO_0004714
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8987255

GO_0004715
has db xref: Reactome:R-HSA-1112602
has db xref: Reactome:R-HSA-1112703
has db xref: Reactome:R-HSA-1168423
has db xref: Reactome:R-HSA-1168459
has db xref: Reactome:R-HSA-1168767
has db xref: Reactome:R-HSA-1295519
has db xref: Reactome:R-HSA-1369115
has db xref: Reactome:R-HSA-432148
has db xref: Reactome:R-HSA-437936
has db xref: Reactome:R-HSA-453200
has db xref: Reactome:R-HSA-6786095
has db xref: Reactome:R-HSA-6786096
has db xref: Reactome:R-HSA-6788582
has db xref: Reactome:R-HSA-879910
has db xref: Reactome:R-HSA-8871373

Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1112602

PTPN11 is phosphorylated
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1112703

JAK2 phosphorylation of IRS-1/2
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168423

Lyn activates ERK
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168459

JAK2 phosphorylates STAT1/STAT3
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168767

IL7R is phosphorylated on Y499
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1295519

SHP2 is phosphorylated
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1369115

Fgr may phosphorylate p38 MAPK
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432148

p-Y348-SYK phosphorylates VAV family
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437936

SYK autophosphorylates
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-453200

JAK1 phosphorylates STAT3,STAT6
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786095

IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786096

STAT1,STAT3,STAT6 phosphorylation
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6788582

JAK2 is phosphorylated, activated
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-879910

BMX phosphorylates RUFY1
type: Axiom
annotated source: GO_0004715
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8871373

GO_0004719
has db xref: Reactome:R-HSA-5676966

PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp
type: Axiom
annotated source: GO_0004719
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5676966

GO_0004720
has db xref: Reactome:R-HSA-2002466
has db xref: Reactome:R-HSA-2129375
has db xref: Reactome:R-HSA-2395340

Formation of allysine by LOX
type: Axiom
annotated source: GO_0004720
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2002466

Elastin cross-linking by lysyl oxidase
type: Axiom
annotated source: GO_0004720
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2129375

Formation of hydroxyallysine by LOX
type: Axiom
annotated source: GO_0004720
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2395340

GO_0004721
has db xref: Reactome:R-HSA-112383
has db xref: Reactome:R-HSA-113503
has db xref: Reactome:R-HSA-1363274
has db xref: Reactome:R-HSA-1363276
has db xref: Reactome:R-HSA-167072
has db xref: Reactome:R-HSA-170153
has db xref: Reactome:R-HSA-170158
has db xref: Reactome:R-HSA-170161
has db xref: Reactome:R-HSA-174110
has db xref: Reactome:R-HSA-174124
has db xref: Reactome:R-HSA-178178
has db xref: Reactome:R-HSA-2529015
has db xref: Reactome:R-HSA-69199
has db xref: Reactome:R-HSA-9636684

Hypophosphorylation of RNA Pol II CTD by FCP1P protein
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112383

PP2A mediated localization of RB1 protein in chromatin
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-113503

Dephosphorylation of p107 (RBL1) by PP2A
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1363274

Dephosphorylation of p130 (RBL2) by PP2A
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1363276

Hypophosphorylation of RNA Pol II CTD by FCP1P protein
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167072

Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170153

Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170158

Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170161

Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174110

Dephosphorylation of phospho-Cdh1
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174124

PP1 dephosphorylates TGFBR1
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-178178

Dephosphorylation of CK2-modified condensin I
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2529015

Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69199

ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP
type: Axiom
annotated source: GO_0004721
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9636684

GO_0004722
has db xref: Reactome:R-HSA-1295632
has db xref: Reactome:R-HSA-163568
has db xref: Reactome:R-HSA-163689
has db xref: Reactome:R-HSA-163750
has db xref: Reactome:R-HSA-1638821
has db xref: Reactome:R-HSA-199425
has db xref: Reactome:R-HSA-199959
has db xref: Reactome:R-HSA-201787
has db xref: Reactome:R-HSA-201790
has db xref: Reactome:R-HSA-209055
has db xref: Reactome:R-HSA-2187401
has db xref: Reactome:R-HSA-2995388
has db xref: Reactome:R-HSA-3002811
has db xref: Reactome:R-HSA-3601585
has db xref: Reactome:R-HSA-380949
has db xref: Reactome:R-HSA-4088141
has db xref: Reactome:R-HSA-429730
has db xref: Reactome:R-HSA-4419948
has db xref: Reactome:R-HSA-5672957
has db xref: Reactome:R-HSA-5672961
has db xref: Reactome:R-HSA-5675431
has db xref: Reactome:R-HSA-5675433
has db xref: Reactome:R-HSA-5679206
has db xref: Reactome:R-HSA-5683405
has db xref: Reactome:R-HSA-5687758
has db xref: Reactome:R-HSA-5692754
has db xref: Reactome:R-HSA-5693153
has db xref: Reactome:R-HSA-5694421
has db xref: Reactome:R-HSA-6792863
has db xref: Reactome:R-HSA-6811504
has db xref: Reactome:R-HSA-74948
has db xref: Reactome:R-HSA-8948139
has db xref: Reactome:R-HSA-9619430
has db xref: Reactome:R-HSA-9619449
has db xref: Reactome:R-HSA-9619467
has db xref: Reactome:R-HSA-9658445
has db xref: Reactome:R-HSA-9660536
has db xref: Reactome:R-HSA-9660538
has db xref: Reactome:R-HSA-9686524
has db xref: Reactome:R-HSA-9831948

PPA2A dephosphorylates SPRY2
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1295632

phosphorylated perilipin + H2O -> perilipin + orthophosphate
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163568

Dephosphorylation of pChREBP (Ser 196) by PP2A
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163689

Dephosphorylation of phosphoPFKFB1 by PP2A complex
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163750

PP2A-B56 dephosphorylates centromeric cohesin
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638821

PHLPP dephosphorylates S473 in AKT
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199425

ERKs are inactivated by protein phosphatase 2A
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199959

PPP3 complex dephosphorylates DARPP-32 on Thr34
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201787

DARPP-32 is dephosphorylated on Thr75 by PP2A
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201790

PPM1A dephosphorylates nuclear SMAD2/3
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209055

MTMR4 dephosphorylates SMAD2/3
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2187401

PP2A dephosphorylates BANF1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2995388

Myosin phosphatase dephosphorylates PLK1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3002811

PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3601585

AMPK is dephosphorylated
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380949

PP2A-PPP2R2A dephosphorylates FOXM1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4088141

PPM1L dephosphorylates multiphospho-CERT1-2
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429730

CTDNEP1:CNEP1R1 dephosphorylates LPIN
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4419948

PP2A dephosphorylates KSR1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672957

PP2A dephosphorylates inactive RAFs
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672961

PP2A dephosphorylates RAF1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675431

PP5 dephosphorylates RAF1 S338
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675433

MTMR14, MTMR3 dephosphorylate PI3P
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5679206

PPP5C dephosphorylates TP53BP1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683405

PPP4C:PPP4R2 dephosphorylates RPA2
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687758

CDC14A,B dephosphorylate p-3S,T MAPK6
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5692754

PPM1K dephosphorylates p-BCKDH
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693153

PP6 dephosphorylates SEC24
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694421

PP2A-PP2R5C dephosphorylates MDM2
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6792863

AKT1 dephosphorylation by PP2A-B56-beta,gamma
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6811504

PP2A dephosphorylates p-RHO to RHO
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74948

p-S13-FUNDC1 is dephosphorylated by PGAM5
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948139

PPM1E dephosphorylates CAMK4
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619430

PPM1F dephosphorylates p-T286-CaMKII
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619449

PPM1F dephosphorylates CAMK1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619467

MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9658445

SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9660536

Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9660538

PP6-PPP6R3 dephosphorylates TERF2
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9686524

P:PP1 dephosphorylates M2-1
type: Axiom
annotated source: GO_0004722
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9831948

GO_0004723
has db xref: Reactome:R-HSA-2025882

Calcineurin dephosphorylates NFATC1,2,3
type: Axiom
annotated source: GO_0004723
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2025882

GO_0004725
has db xref: Reactome:R-HSA-1169188
has db xref: Reactome:R-HSA-1169192
has db xref: Reactome:R-HSA-1169210
has db xref: Reactome:R-HSA-1549564
has db xref: Reactome:R-HSA-202214
has db xref: Reactome:R-HSA-203797
has db xref: Reactome:R-HSA-377643
has db xref: Reactome:R-HSA-389758
has db xref: Reactome:R-HSA-391868
has db xref: Reactome:R-HSA-445089
has db xref: Reactome:R-HSA-5683967
has db xref: Reactome:R-HSA-6807008
has db xref: Reactome:R-HSA-6807027
has db xref: Reactome:R-HSA-74733
has db xref: Reactome:R-HSA-74747
has db xref: Reactome:R-HSA-74748
has db xref: Reactome:R-HSA-877308
has db xref: Reactome:R-HSA-8849435
has db xref: Reactome:R-HSA-8852200
has db xref: Reactome:R-HSA-8855381
has db xref: Reactome:R-HSA-8863804
has db xref: Reactome:R-HSA-8864029
has db xref: Reactome:R-HSA-8864036
has db xref: Reactome:R-HSA-8864125
has db xref: Reactome:R-HSA-8867047
has db xref: Reactome:R-HSA-8867658
has db xref: Reactome:R-HSA-8937767
has db xref: Reactome:R-HSA-914036
has db xref: Reactome:R-HSA-9603719
has db xref: Reactome:R-HSA-9635461
has db xref: Reactome:R-HSA-9636439
has db xref: Reactome:R-HSA-9674816
has db xref: Reactome:R-HSA-9698408
has db xref: Reactome:R-HSA-9700200
has db xref: Reactome:R-HSA-9701507
has db xref: Reactome:R-HSA-997309
has db xref: Reactome:R-HSA-997311
has db xref: Reactome:R-HSA-997314
has db xref: Reactome:R-HSA-997326

SHP1 (PTPN6) dephosphorylates JAK2
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169188

PTP1B dephosphorylates GHR
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169192

PTP1B dephosphorylates JAK2
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169210

PPTN11 dephosphorylates SPRY2
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1549564

Dephosphorylation of Lck-pY505 by CD45
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202214

ERKs are inactivated by dual-specific phosphatases (DUSPs)
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203797

Dephosphorylation of inactive SRC by PTPB1
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-377643

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389758

Dephosphorylation of NCAM1 bound pFyn
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-391868

Dephosphorylation of pL1 (Y1176)
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445089

EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683967

PTPRJ dephosphorylates MET
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807008

PTPN1 and PTPN2 dephosphorylate MET
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807027

Insulin receptor de-phosphorylation
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74733

Dephosphorylation of p-Y-IRS1,p-Y-IRS2
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74747

De-phosphorylation of p-Y427-SHC1
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74748

Dephosphorylation of JAKs by PTPs
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-877308

PTPN1 dephosphorylates PTK6
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8849435

Inactivation of LCK by PTPN22
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852200

PTPN22 dephosphorylates ZAP70
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855381

PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8863804

PTPN12 dephosphorylates EGFR at Y1172 (Y1148)
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8864029

PTPN12 dephosphorylates PDGFRB at Y1021
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8864036

PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8864125

PTPN3 dephosphorylates EPS15
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8867047

PTPN3 dephosphorylates MAPK12
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8867658

PTPN11 dephosphorylates RUNX1
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8937767

SHP1 and SHP2 dephosphorylate Y628 of IL3RB
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-914036

Protein tyrosine phosphatases dephosphorylate NTRK3
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603719

PtpA dephosphorylates GSK3A
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9635461

PtpA:Ub dephosphorylates p-Y133-VPS33B
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9636439

p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9674816

PTPRJ dephosphorylates active FLT3
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698408

PTPRZ dephosphorylates ligand-bound ALK dimers
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9700200

PTPN6 dephosphorylates JAK3
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9701507

Dephosphorylation of STAT1 by SHP2
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-997309

Dephosphorylation of TYK2 by PTP1B
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-997311

Dephosphorylation of JAK1 by SHP1
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-997314

Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
type: Axiom
annotated source: GO_0004725
annotated property: hasDbXref
annotated target: Reactome:R-HSA-997326

GO_0004726
has db xref: Reactome:R-HSA-177923
has db xref: Reactome:R-HSA-177924
has db xref: Reactome:R-HSA-177926
has db xref: Reactome:R-HSA-177935
has db xref: Reactome:R-HSA-9635739

Sustained activation of SRC kinase by SHP2
type: Axiom
annotated source: GO_0004726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177923

Dephosphorylation of Gab1 by SHP2
type: Axiom
annotated source: GO_0004726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177924

Dephosphorylation of PAG by SHP2
type: Axiom
annotated source: GO_0004726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177926

SHP2 dephosphorylates Tyr 992 on EGFR
type: Axiom
annotated source: GO_0004726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177935

PTPN7 dephosphorylates p-T,Y-MAPKs
type: Axiom
annotated source: GO_0004726
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9635739

GO_0004729
has db xref: Reactome:R-HSA-189423

PPO oxidises PPGEN9 to PRIN9
type: Axiom
annotated source: GO_0004729
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189423

GO_0004731
has db xref: Reactome:R-HSA-112033
has db xref: Reactome:R-HSA-112034
has db xref: Reactome:R-HSA-74242
has db xref: Reactome:R-HSA-74249
has db xref: Reactome:R-HSA-9735775
has db xref: Reactome:R-HSA-9735789
has db xref: Reactome:R-HSA-9755044

PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112033

PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-112034

PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74242

PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74249

Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9735775

Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9735789

PNP trimer transforms RBV to T-CONH2
type: Axiom
annotated source: GO_0004731
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755044

GO_0004733
has db xref: Reactome:R-HSA-965019
has db xref: Reactome:R-HSA-965079

2xPNPO:2xFMN oxidizes PDXP to PXLP
type: Axiom
annotated source: GO_0004733
annotated property: hasDbXref
annotated target: Reactome:R-HSA-965019

2xPNPO:2xFMN oxidizes PXAP to PXLP
type: Axiom
annotated source: GO_0004733
annotated property: hasDbXref
annotated target: Reactome:R-HSA-965079

GO_0004735
has db xref: Reactome:R-HSA-6783939
has db xref: Reactome:R-HSA-6783955
has db xref: Reactome:R-HSA-70664

PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
type: Axiom
annotated source: GO_0004735
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6783939

PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
type: Axiom
annotated source: GO_0004735
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6783955

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
type: Axiom
annotated source: GO_0004735
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70664

GO_0004736
has db xref: Reactome:R-HSA-70501

PC catalyzes the carboxylation of PYR to form OA
type: Axiom
annotated source: GO_0004736
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70501

GO_0004738
has db xref: Reactome:R-HSA-71397

lipo-PDH decarboxylates PYR to Ac-CoA
type: Axiom
annotated source: GO_0004738
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71397

GO_0004740
has db xref: Reactome:R-HSA-203946

PDK isoforms phosphorylate lipo-PDH
type: Axiom
annotated source: GO_0004740
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203946

GO_0004741
has db xref: Reactome:R-HSA-204169

PDP dephosphorylates p-lipo-PDH
type: Axiom
annotated source: GO_0004741
annotated property: hasDbXref
annotated target: Reactome:R-HSA-204169

GO_0004743
has db xref: Reactome:R-HSA-71670

phosphoenolpyruvate + ADP => pyruvate + ATP
type: Axiom
annotated source: GO_0004743
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71670

GO_0004745
has db xref: Reactome:R-HSA-2454081
has db xref: Reactome:R-HSA-2466832
has db xref: Reactome:R-HSA-5362518
has db xref: Reactome:R-HSA-5362564
has db xref: Reactome:R-HSA-5362721

RDH5 oxidises 11cROL to 11cRAL
type: Axiom
annotated source: GO_0004745
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2454081

Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA
type: Axiom
annotated source: GO_0004745
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2466832

RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL
type: Axiom
annotated source: GO_0004745
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362518

ADH1A,1C,4 oxidise atROL to atRAL in vitro
type: Axiom
annotated source: GO_0004745
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362564

RDH5,RDH11 oxidise 11cROL to 11cRAL
type: Axiom
annotated source: GO_0004745
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362721

GO_0004747
has db xref: Reactome:R-HSA-8955844

RBKS phosphorylates ribose to R5P
type: Axiom
annotated source: GO_0004747
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8955844

GO_0004748
has db xref: Reactome:R-HSA-111751
has db xref: Reactome:R-HSA-111804

RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
type: Axiom
annotated source: GO_0004748
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111751

RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
type: Axiom
annotated source: GO_0004748
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111804

GO_0004749
has db xref: Reactome:R-HSA-111215
has db xref: Reactome:R-HSA-73580

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
type: Axiom
annotated source: GO_0004749
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111215

D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate
type: Axiom
annotated source: GO_0004749
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73580

GO_0004750
has db xref: Reactome:R-HSA-199803
has db xref: Reactome:R-HSA-71303

xylulose 5-phosphate <=> D-ribulose 5-phosphate
type: Axiom
annotated source: GO_0004750
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199803

RPE dimers isomerise RU5P to XY5P
type: Axiom
annotated source: GO_0004750
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71303

GO_0004751
has db xref: Reactome:R-HSA-177784
has db xref: Reactome:R-HSA-5660013
has db xref: Reactome:R-HSA-5660015
has db xref: Reactome:R-HSA-71306

ribose 5-phosphate <=> D-ribulose 5-phosphate
type: Axiom
annotated source: GO_0004751
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177784

Defective RPIA does not isomerize RU5P to R5P
type: Axiom
annotated source: GO_0004751
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660013

Defective RPIA does not isomerize R5P to RU5P
type: Axiom
annotated source: GO_0004751
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660015

D-ribulose 5-phosphate <=> ribose 5-phosphate
type: Axiom
annotated source: GO_0004751
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71306

GO_0004756
has db xref: Reactome:R-HSA-8959510

SEPHS2 phosphorylates H2Se to form SELP
type: Axiom
annotated source: GO_0004756
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8959510

GO_0004757
has db xref: Reactome:R-HSA-1475414
has db xref: Reactome:R-HSA-1497869

PTHP is reduced to BH4 by sepiapterin reductase (SPR)
type: Axiom
annotated source: GO_0004757
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1475414

Salvage - Sepiapterin is reduced to BH2
type: Axiom
annotated source: GO_0004757
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1497869

GO_0004758
has db xref: Reactome:R-HSA-428127

SPTLC complexes transfer acyl-CoA onto serine
type: Axiom
annotated source: GO_0004758
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428127

GO_0004766
has db xref: Reactome:R-HSA-351215

Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
type: Axiom
annotated source: GO_0004766
annotated property: hasDbXref
annotated target: Reactome:R-HSA-351215

GO_0004767
has db xref: Reactome:R-HSA-1605797
has db xref: Reactome:R-HSA-1606273
has db xref: Reactome:R-HSA-1606288
has db xref: Reactome:R-HSA-1640164
has db xref: Reactome:R-HSA-193706

SMPD1 hydrolyzes SPHM
type: Axiom
annotated source: GO_0004767
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1605797

SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)
type: Axiom
annotated source: GO_0004767
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606273

SMPD4 hydrolyzes sphingomyelin (ER membrane)
type: Axiom
annotated source: GO_0004767
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606288

ENPP7 hydrolyzes sphingomyelin
type: Axiom
annotated source: GO_0004767
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1640164

Production of ceramide which can activate JNK and other targets
type: Axiom
annotated source: GO_0004767
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193706

GO_0004768
has db xref: Reactome:R-HSA-5690565
has db xref: Reactome:R-HSA-8847579

SCD desaturates ST-CoA to OLE-CoA
type: Axiom
annotated source: GO_0004768
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690565

SCD5 desaturates ST-CoA to OLE-CoA
type: Axiom
annotated source: GO_0004768
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8847579

GO_0004769
has db xref: Reactome:R-HSA-193052
has db xref: Reactome:R-HSA-193073
has db xref: Reactome:R-HSA-193961
has db xref: Reactome:R-HSA-195690
has db xref: Reactome:R-HSA-6807052

Pregn-5-ene-3,20-dione isomerizes to progesterone
type: Axiom
annotated source: GO_0004769
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193052

HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
type: Axiom
annotated source: GO_0004769
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193073

Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
type: Axiom
annotated source: GO_0004769
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193961

Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol
type: Axiom
annotated source: GO_0004769
annotated property: hasDbXref
annotated target: Reactome:R-HSA-195690

EBP isomerizes ZYMSTNL to LTHSOL
type: Axiom
annotated source: GO_0004769
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807052

GO_0004771
has db xref: Reactome:R-HSA-192417
has db xref: Reactome:R-HSA-6813720
has db xref: Reactome:R-HSA-8865667

Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
type: Axiom
annotated source: GO_0004771
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192417

NCEH1 hydrolyzes cholesterol esters
type: Axiom
annotated source: GO_0004771
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6813720

LIPA hydrolyses sterol esters to sterols and fatty acids
type: Axiom
annotated source: GO_0004771
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865667

GO_0004773
has db xref: Reactome:R-HSA-1606839

ARSC hydrolyzes steroid sulfates
type: Axiom
annotated source: GO_0004773
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1606839

GO_0004775
has db xref: Reactome:R-HSA-70997

ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA
type: Axiom
annotated source: GO_0004775
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70997

GO_0004776
has db xref: Reactome:R-HSA-71775

GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA
type: Axiom
annotated source: GO_0004776
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71775

GO_0004777
has db xref: Reactome:R-HSA-888548

ALDH5A1 dehydrogenates SUCCSA to SUCCA
type: Axiom
annotated source: GO_0004777
annotated property: hasDbXref
annotated target: Reactome:R-HSA-888548

GO_0004781
has db xref: Reactome:R-HSA-174392
has db xref: Reactome:R-HSA-3560794

PAPSS1,2 transfer SO4(2-) group to ATP to form APS
type: Axiom
annotated source: GO_0004781
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174392

Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS
type: Axiom
annotated source: GO_0004781
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3560794

GO_0004782
has db xref: Reactome:R-HSA-1655443

PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine
type: Axiom
annotated source: GO_0004782
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1655443

GO_0004784
has db xref: Reactome:R-HSA-1222462
has db xref: Reactome:R-HSA-1222469
has db xref: Reactome:R-HSA-3299680
has db xref: Reactome:R-HSA-3299682
has db xref: Reactome:R-HSA-3299691
has db xref: Reactome:R-HSA-3777112

SodB reduces superoxide to H2O2
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222462

SodC reduces superoxide to H2O2
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222469

SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3299680

SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3299682

SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3299691

SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
type: Axiom
annotated source: GO_0004784
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3777112

GO_0004788
has db xref: Reactome:R-HSA-196761

2xTPK1:Mg2+ phosphorylates THMN
type: Axiom
annotated source: GO_0004788
annotated property: hasDbXref
annotated target: Reactome:R-HSA-196761

GO_0004791
has db xref: Reactome:R-HSA-1222485
has db xref: Reactome:R-HSA-3323050
has db xref: Reactome:R-HSA-73646
has db xref: Reactome:R-HSA-9617735

TrxB reactivates TrxA
type: Axiom
annotated source: GO_0004791
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222485

TXNRD2 catalyzes the reduction of TXN2 by NADPH
type: Axiom
annotated source: GO_0004791
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3323050

thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
type: Axiom
annotated source: GO_0004791
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73646

TXN disrupts FOXO4 complex with EP300
type: Axiom
annotated source: GO_0004791
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9617735

GO_0004792
has db xref: Reactome:R-HSA-9013198

TST transfers sulfur from S2O3(2-) to HCN to form HSCN
type: Axiom
annotated source: GO_0004792
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013198

GO_0004796
has db xref: Reactome:R-HSA-5603275
has db xref: Reactome:R-HSA-76500

Defective TBXAS1 does not isomerise PGH2 to TXA2
type: Axiom
annotated source: GO_0004796
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603275

TBXAS1 isomerises PGH2 to TXA2
type: Axiom
annotated source: GO_0004796
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76500

GO_0004799
has db xref: Reactome:R-HSA-73605

dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
type: Axiom
annotated source: GO_0004799
annotated property: hasDbXref
annotated target: Reactome:R-HSA-73605

GO_0004800
has db xref: Reactome:R-HSA-209772
has db xref: Reactome:R-HSA-350869

Thyroxine is deiodinated to triiodothyronine
type: Axiom
annotated source: GO_0004800
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209772

Thyroxine is deiodinated to reverse triiodothyronine (RT3)
type: Axiom
annotated source: GO_0004800
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350869

GO_0004801
has db xref: Reactome:R-HSA-163764
has db xref: Reactome:R-HSA-5659989
has db xref: Reactome:R-HSA-5659998
has db xref: Reactome:R-HSA-71334

D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: Axiom
annotated source: GO_0004801
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163764

Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P
type: Axiom
annotated source: GO_0004801
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659989

Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P
type: Axiom
annotated source: GO_0004801
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659998

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate
type: Axiom
annotated source: GO_0004801
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71334

GO_0004802
has db xref: Reactome:R-HSA-163741
has db xref: Reactome:R-HSA-163751
has db xref: Reactome:R-HSA-71324
has db xref: Reactome:R-HSA-71335

D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
type: Axiom
annotated source: GO_0004802
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163741

D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate
type: Axiom
annotated source: GO_0004802
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163751

ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
type: Axiom
annotated source: GO_0004802
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71324

xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
type: Axiom
annotated source: GO_0004802
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71335

GO_0004806
has db xref: Reactome:R-HSA-1482777
has db xref: Reactome:R-HSA-163551
has db xref: Reactome:R-HSA-5694109
has db xref: Reactome:R-HSA-8848338
has db xref: Reactome:R-HSA-8848339

TAG is hydrolyzed to DAG by PNPLA2/3
type: Axiom
annotated source: GO_0004806
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482777

triacylglycerol + H2O -> diacylglycerol + fatty acid
type: Axiom
annotated source: GO_0004806
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163551

LIPC dimer hydrolyses TAG to DAG and FA
type: Axiom
annotated source: GO_0004806
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694109

PNPLA4 hydrolyzes TAG
type: Axiom
annotated source: GO_0004806
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848338

PNPLA5 hydrolyzes TAG
type: Axiom
annotated source: GO_0004806
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848339

GO_0004807
has db xref: Reactome:R-HSA-70454
has db xref: Reactome:R-HSA-70481

dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate
type: Axiom
annotated source: GO_0004807
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70454

TPI1 isomerizes GA3P to DHAP
type: Axiom
annotated source: GO_0004807
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70481

GO_0004813
has db xref: Reactome:R-HSA-379864
has db xref: Reactome:R-HSA-380177

alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004813
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379864

alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004813
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380177

GO_0004814
has db xref: Reactome:R-HSA-379993
has db xref: Reactome:R-HSA-380224

arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004814
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379993

arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004814
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380224

GO_0004815
has db xref: Reactome:R-HSA-379867
has db xref: Reactome:R-HSA-380229

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004815
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379867

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004815
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380229

GO_0004816
has db xref: Reactome:R-HSA-379996
has db xref: Reactome:R-HSA-380227

asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004816
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379996

asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004816
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380227

GO_0004817
has db xref: Reactome:R-HSA-379887
has db xref: Reactome:R-HSA-380158

cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004817
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379887

cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004817
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380158

GO_0004818
has db xref: Reactome:R-HSA-379861
has db xref: Reactome:R-HSA-380216

glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004818
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379861

glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004818
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380216

GO_0004819
has db xref: Reactome:R-HSA-379982
has db xref: Reactome:R-HSA-380241

glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004819
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379982

glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004819
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380241

GO_0004820
has db xref: Reactome:R-HSA-380048
has db xref: Reactome:R-HSA-380240

glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004820
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380048

glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004820
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380240

GO_0004821
has db xref: Reactome:R-HSA-379844
has db xref: Reactome:R-HSA-380234

histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004821
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379844

histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004821
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380234

GO_0004822
has db xref: Reactome:R-HSA-379893
has db xref: Reactome:R-HSA-380176

isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004822
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379893

isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004822
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380176

GO_0004823
has db xref: Reactome:R-HSA-379974
has db xref: Reactome:R-HSA-380200

leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004823
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379974

leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004823
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380200

GO_0004824
has db xref: Reactome:R-HSA-380008
has db xref: Reactome:R-HSA-380233

lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004824
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380008

lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004824
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380233

GO_0004825
has db xref: Reactome:R-HSA-379994
has db xref: Reactome:R-HSA-380157

methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004825
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379994

methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004825
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380157

GO_0004826
has db xref: Reactome:R-HSA-379848
has db xref: Reactome:R-HSA-380203

phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004826
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379848

phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004826
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380203

GO_0004827
has db xref: Reactome:R-HSA-379865
has db xref: Reactome:R-HSA-380198

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004827
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379865

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004827
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380198

GO_0004828
has db xref: Reactome:R-HSA-379992
has db xref: Reactome:R-HSA-380239

serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379992

serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004828
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380239

GO_0004829
has db xref: Reactome:R-HSA-380002
has db xref: Reactome:R-HSA-380201

threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380002

threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004829
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380201

GO_0004830
has db xref: Reactome:R-HSA-379977
has db xref: Reactome:R-HSA-380222

tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004830
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379977

tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004830
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380222

GO_0004831
has db xref: Reactome:R-HSA-379980
has db xref: Reactome:R-HSA-380170

tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379980

tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004831
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380170

GO_0004832
has db xref: Reactome:R-HSA-380042
has db xref: Reactome:R-HSA-380199

valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004832
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380042

valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
type: Axiom
annotated source: GO_0004832
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380199

GO_0004833
has db xref: Reactome:R-HSA-198563
has db xref: Reactome:R-HSA-71188
has db xref: Reactome:R-HSA-888614

IDO1 dioxygenates L-Trp to NFK
type: Axiom
annotated source: GO_0004833
annotated property: hasDbXref
annotated target: Reactome:R-HSA-198563

TDO tetramer dioxygenates L-Trp to NFK
type: Axiom
annotated source: GO_0004833
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71188

IDO2 dioxygenates L-Trp to NFK
type: Axiom
annotated source: GO_0004833
annotated property: hasDbXref
annotated target: Reactome:R-HSA-888614

GO_0004835
has db xref: Reactome:R-HSA-8955706

TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin
type: Axiom
annotated source: GO_0004835
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8955706

GO_0004838
has db xref: Reactome:R-HSA-517444
has db xref: Reactome:R-HSA-71155

p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate
type: Axiom
annotated source: GO_0004838
annotated property: hasDbXref
annotated target: Reactome:R-HSA-517444

tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate
type: Axiom
annotated source: GO_0004838
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71155

GO_0004839
has db xref: Reactome:R-HSA-8852132
has db xref: Reactome:R-HSA-8852133
has db xref: Reactome:R-HSA-8852134
has db xref: Reactome:R-HSA-8865050
has db xref: Reactome:R-HSA-8865090
has db xref: Reactome:R-HSA-8865098

Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852132

UBA1 conjugates ubiquitin to UBA1 in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852133

UBA1 adenylates ubiquitin in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8852134

Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865050

UBA6 adenylates ubiquitin in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865090

UBA6 conjugates ubiquitin to UBA6 in the cytosol
type: Axiom
annotated source: GO_0004839
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865098

GO_0004842
has db xref: Reactome:R-HSA-1169394
has db xref: Reactome:R-HSA-1169395
has db xref: Reactome:R-HSA-1169397
has db xref: Reactome:R-HSA-1169398
has db xref: Reactome:R-HSA-1169402
has db xref: Reactome:R-HSA-1169405
has db xref: Reactome:R-HSA-1169406
has db xref: Reactome:R-HSA-1234163
has db xref: Reactome:R-HSA-1234172
has db xref: Reactome:R-HSA-1253282
has db xref: Reactome:R-HSA-1358789
has db xref: Reactome:R-HSA-1358790
has db xref: Reactome:R-HSA-1358792
has db xref: Reactome:R-HSA-1363331
has db xref: Reactome:R-HSA-168915
has db xref: Reactome:R-HSA-173542
has db xref: Reactome:R-HSA-173545
has db xref: Reactome:R-HSA-174057
has db xref: Reactome:R-HSA-174104
has db xref: Reactome:R-HSA-174144
has db xref: Reactome:R-HSA-174159
has db xref: Reactome:R-HSA-174195
has db xref: Reactome:R-HSA-174227
has db xref: Reactome:R-HSA-179417
has db xref: Reactome:R-HSA-180540
has db xref: Reactome:R-HSA-180597
has db xref: Reactome:R-HSA-182986
has db xref: Reactome:R-HSA-182993
has db xref: Reactome:R-HSA-183051
has db xref: Reactome:R-HSA-183084
has db xref: Reactome:R-HSA-183089
has db xref: Reactome:R-HSA-1852623
has db xref: Reactome:R-HSA-187575
has db xref: Reactome:R-HSA-1912357
has db xref: Reactome:R-HSA-1912386
has db xref: Reactome:R-HSA-1918092
has db xref: Reactome:R-HSA-1918095
has db xref: Reactome:R-HSA-1977296
has db xref: Reactome:R-HSA-1980074
has db xref: Reactome:R-HSA-1980118
has db xref: Reactome:R-HSA-201425
has db xref: Reactome:R-HSA-202453
has db xref: Reactome:R-HSA-202534
has db xref: Reactome:R-HSA-205118
has db xref: Reactome:R-HSA-209063
has db xref: Reactome:R-HSA-211734
has db xref: Reactome:R-HSA-2169050
has db xref: Reactome:R-HSA-2172172
has db xref: Reactome:R-HSA-2179276
has db xref: Reactome:R-HSA-2186747
has db xref: Reactome:R-HSA-2186785
has db xref: Reactome:R-HSA-2187368
has db xref: Reactome:R-HSA-2213017
has db xref: Reactome:R-HSA-264444
has db xref: Reactome:R-HSA-2682349
has db xref: Reactome:R-HSA-2730904
has db xref: Reactome:R-HSA-2737728
has db xref: Reactome:R-HSA-2769007
has db xref: Reactome:R-HSA-2900765
has db xref: Reactome:R-HSA-3000335
has db xref: Reactome:R-HSA-3134804
has db xref: Reactome:R-HSA-3134946
has db xref: Reactome:R-HSA-3249386
has db xref: Reactome:R-HSA-3780995
has db xref: Reactome:R-HSA-3781009
has db xref: Reactome:R-HSA-3788724
has db xref: Reactome:R-HSA-3797226
has db xref: Reactome:R-HSA-400267
has db xref: Reactome:R-HSA-4332236
has db xref: Reactome:R-HSA-446877
has db xref: Reactome:R-HSA-450358
has db xref: Reactome:R-HSA-451418
has db xref: Reactome:R-HSA-5205682
has db xref: Reactome:R-HSA-5357757
has db xref: Reactome:R-HSA-5362412
has db xref: Reactome:R-HSA-5483238
has db xref: Reactome:R-HSA-5607725
has db xref: Reactome:R-HSA-5607728
has db xref: Reactome:R-HSA-5607756
has db xref: Reactome:R-HSA-5607757

ISGylation of IRF3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169394

ISGylation of viral protein NS1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169395

Activation of ISG15 by UBA7 E1 ligase
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169397

ISGylation of host protein filamin B
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169398

ISGylation of E2 conjugating enzymes
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169402

ISGylation of protein phosphatase 1 beta (PP2CB)
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169405

ISGylation of host proteins
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1169406

Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1234163

Nuclear VBC complex ubiquitinylates HIF-alpha
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1234172

ERBB4 ubiquitination by WWP1/ITCH
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1253282

Self-ubiquitination of RNF41
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1358789

RNF41 ubiquitinates ERBB3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1358790

RNF41 ubiquitinates activated ERBB3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1358792

Ubiquitination of p130 (RBL2) by SCF (Skp2)
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1363331

K63-linked ubiquitination of RIP1 bound to the activated TLR complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-168915

SMURF2 ubiquitinates SMAD2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173542

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-173545

Multiubiquitination of APC/C-associated Cdh1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174057

Ubiquitination of Cyclin A by APC/C:Cdc20 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174104

Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174144

Ubiquitination of Emi1 by SCF-beta-TrCP
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174159

Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174195

Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174227

Multiubiquitination of Nek2A
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-179417

Multi-ubiquitination of APOBEC3G
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180540

Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180597

CBL-mediated ubiquitination of CIN85
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-182986

Ubiquitination of stimulated EGFR (CBL)
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-182993

CBL ubiquitinates Sprouty
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183051

CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183084

CBL binds and ubiquitinates phosphorylated Sprouty
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-183089

Ubiquitination of NICD1 by FBWX7
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1852623

Ubiquitination of phospho-p27/p21
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187575

ITCH ubiquitinates DTX
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912357

Ubiquitination of NOTCH1 by ITCH in the absence of ligand
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1912386

CHIP (STUB1) mediates ubiquitination of ERBB2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1918092

CUL5 mediates ubiquitination of ERBB2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1918095

NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1977296

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1980074

ARRB mediates NOTCH1 ubiquitination
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1980118

Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-201425

Auto-ubiquitination of TRAF6
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202453

Ubiquitination of NEMO by TRAF6
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-202534

TRAF6 polyubiquitinates NRIF
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205118

Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209063

Ubiquitination of PAK-2p34
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211734

SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2169050

Ubiquitination of DLL/JAG ligands upon binding to NOTCH2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2172172

SMURF2 monoubiquitinates SMAD3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2179276

Ubiquitination of SKI/SKIL by RNF111/SMURF2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2186747

RNF111 ubiquitinates SMAD7
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2186785

STUB1 (CHIP) ubiquitinates SMAD3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2187368

Auto-ubiquitination of TRAF3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2213017

Autoubiquitination of phospho-COP1(Ser-387 )
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264444

RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2682349

Auto-ubiquitination of TRAF6
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730904

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2737728

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2769007

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2900765

SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3000335

STING ubiquitination by TRIM32 or TRIM56
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3134804

DDX41 ubiquitination by TRIM21
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3134946

DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3249386

NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3780995

NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3781009

Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3788724

Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3797226

BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-400267

CBL neddylates TGFBR2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4332236

TRAF6 is K63 poly-ubiquitinated
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446877

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-450358

Pellino ubiquitinates IRAK1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-451418

Parkin promotes the ubiquitination of mitochondrial substrates
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5205682

BIRC(cIAP1/2) ubiquitinates RIPK1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5357757

SYVN1 ubiquitinates Hh C-terminal fragments
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362412

Hh processing variants are ubiquitinated
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5483238

SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607725

beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607728

TRAF6 oligomer autoubiquitinates
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607756

K63polyUb-TRAF6 ubiquitinates TAK1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5607757

SCF(beta-TrCP) ubiquitinates p-GLI1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610742

SCF(beta-TrCP) ubiquitinates p-GLI2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610745

SCF(beta-TrCP) ubiquitinates p-GLI3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610746

RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5652009

RCHY1 monoubiquitinates POLH
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655170

SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660753

SIAH1, SIAH2 ubiquitinate SNCAIP
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5667107

PARK2 K63-Ubiquitinates SNCAIP
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5667111

K63polyUb-cIAP1,2 ubiquitinates TRAF3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668454

cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5668534

BIRC2/3 (cIAP1/2) is autoubiquitinated
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675470

SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684250

SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5691108

TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693108

The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-68712

Ubiquitination of phosphorylated Cdc25A
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69598

RIP2 induces K63-linked ubiquitination of NEMO
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-741386

Ubiquitination of Cyclin D1
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75824

TRIM33 monoubiquitinates SMAD4
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-870449

DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8948709

VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8956106

Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013069

Auto-ubiquitination of TRAF3 within activated TLR3 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013974

K63-linked ubiquitination of RIP1 bound to the activated TLR complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9014342

DDX58 is K63 polyubiquitinated
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-918224

RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936412

Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936942

Activated TRAF6 synthesizes unanchored polyubiquitin chains
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936986

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9628444

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645394

Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645414

STUB1 ubiquitinates RIPK3 at K55, K363
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9688831

BRCA1:BARD1 heterodimer autoubiquitinates
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9701000

TRAF2,6 ubiquitinates NLRC5
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9750946

TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975118

Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975147

Ubiquitination of IKBKG by TRAF6
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9758604

ITCH polyubiquitinates MLKL at K50
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9793444

PRKN polyubiquitinates RIPK3
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9793485

LUBAC ubiquitinates RIPK1 at K627
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9793679

MIB2 ubiquitinates RIPK1 at K377, K604, K634
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796346

STUB1 ubiquitinates RIPK1 at K571, K604, K627
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796387

MIB2 ubiquitinates CFLAR
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9796626

MIB2 ubiquitinates CYLD at K338, K530
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9815507

SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9817362

Transfer of Ub from E2 to substrate and release of E2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983140

E1 mediated ubiquitin activation
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983153

Polyubiquitination of substrate
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-983156

Ubiquitination of STAT2
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9833155

ISGylation of PKR
type: Axiom
annotated source: GO_0004842
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9833973

GO_0004843
has db xref: Reactome:R-HSA-1358795
has db xref: Reactome:R-HSA-2179291
has db xref: Reactome:R-HSA-3215295
has db xref: Reactome:R-HSA-3215310
has db xref: Reactome:R-HSA-3640872
has db xref: Reactome:R-HSA-4641236
has db xref: Reactome:R-HSA-5653770
has db xref: Reactome:R-HSA-5655466
has db xref: Reactome:R-HSA-5688797
has db xref: Reactome:R-HSA-5688837
has db xref: Reactome:R-HSA-5689950
has db xref: Reactome:R-HSA-5689972
has db xref: Reactome:R-HSA-5689973
has db xref: Reactome:R-HSA-5690080
has db xref: Reactome:R-HSA-5690152
has db xref: Reactome:R-HSA-5690157
has db xref: Reactome:R-HSA-5690159
has db xref: Reactome:R-HSA-5690196
has db xref: Reactome:R-HSA-5690319
has db xref: Reactome:R-HSA-5690759
has db xref: Reactome:R-HSA-5690790
has db xref: Reactome:R-HSA-5691381
has db xref: Reactome:R-HSA-5696465
has db xref: Reactome:R-HSA-5696534
has db xref: Reactome:R-HSA-5696564
has db xref: Reactome:R-HSA-5696600
has db xref: Reactome:R-HSA-5696605
has db xref: Reactome:R-HSA-5696627
has db xref: Reactome:R-HSA-5696872
has db xref: Reactome:R-HSA-5696914
has db xref: Reactome:R-HSA-5696945
has db xref: Reactome:R-HSA-5696947
has db xref: Reactome:R-HSA-5696958
has db xref: Reactome:R-HSA-5696960
has db xref: Reactome:R-HSA-5696968
has db xref: Reactome:R-HSA-5696997
has db xref: Reactome:R-HSA-5697009
has db xref: Reactome:R-HSA-6781764
has db xref: Reactome:R-HSA-6781779
has db xref: Reactome:R-HSA-6781814
has db xref: Reactome:R-HSA-6781897
has db xref: Reactome:R-HSA-6782069
has db xref: Reactome:R-HSA-6782106
has db xref: Reactome:R-HSA-6782628
has db xref: Reactome:R-HSA-6782820
has db xref: Reactome:R-HSA-6783177
has db xref: Reactome:R-HSA-6786171
has db xref: Reactome:R-HSA-6807118
has db xref: Reactome:R-HSA-6807206
has db xref: Reactome:R-HSA-870437
has db xref: Reactome:R-HSA-8853503
has db xref: Reactome:R-HSA-8853514
has db xref: Reactome:R-HSA-8853515
has db xref: Reactome:R-HSA-8853529
has db xref: Reactome:R-HSA-8862184
has db xref: Reactome:R-HSA-8865182
has db xref: Reactome:R-HSA-8869456
has db xref: Reactome:R-HSA-8873946
has db xref: Reactome:R-HSA-8875443
has db xref: Reactome:R-HSA-8986083
has db xref: Reactome:R-HSA-9033478
has db xref: Reactome:R-HSA-9033491
has db xref: Reactome:R-HSA-9653514

Deubiquitination of RNF41 by P-USP8
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1358795

UCHL5, USP15 deubiquitinate TGFBR1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2179291

USP7 deubiquitinates MDM2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3215295

USP7 deubiquitinates TP53 and counteracts MDM2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3215310

USP34 deubiquitinates AXIN1,AXIN2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3640872

USP8 deubiquitinates FZD to potentiate WNT signaling
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4641236

USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653770

USP1:WDR48 deubiquitinates monoUb:K164-PCNA
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655466

ATXN3 family cleave Ub chains
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5688797

ATXN3 deubiquitinates polyUb-PARK2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5688837

USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5689950

USP2 deubiquitinates MDM2,MDM4
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5689972

USP10,USP24,USP42 deubiquitinate TP53
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5689973

USP3,SAGA deubiquitinate Histone H2A,H2B
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690080

USP5 cleaves polyubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690152

USP16,USP21 deubiquitinate Histone H2A
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690157

USP21 deubiquitinates RIPK1,DDX58
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690159

USP8 deubiquitinates RNF128
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690196

UCHL1, UCHL3 cleave ubiquitin adducts
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690319

BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690759

Histone H2A is dubiquitinated by the PR-DUB complex
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690790

MYSM1 deubiquitinates Histone H2A
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5691381

USP45 deubiquitinates ERCC1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696465

USP18 deubiquitinates TAK1:TAB1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696534

USP25 deubiquitinates DDX58
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696564

USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696600

USP12, USP26 deubiquitinate AR
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696605

CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696627

USP30 deubiquitinates Ub-MOM proteins
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696872

USP28 deubiquitinates CLSPN and MYC
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696914

USP33 deubiquitinates CCP110,ARRB
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696945

USP47 deubiquitinates POLB
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696947

USP44 deubiquitinates CDC20
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696958

USP49 deubiquitinates H2B
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696960

USP20, USP33 deubiquitinate ADRB2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696968

USP24 deubiquitinates DDB2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696997

USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5697009

USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6781764

USP13 deubiquitinates BECN1,USP10
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6781779

USP19 deubiquitinates RNF123
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6781814

USP11 deubiquitinates NFKBIA
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6781897

UVSSA:USP7 deubiquitinates ERCC6
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782069

USP10 deubiquitinates SNX3, CFTR
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782106

USP8 deubiquitinates STAM2:HGS
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782628

USP17 deubiquitinates SUDS3
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782820

USP21 deubiquitinates GATA3,IL33
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6783177

FANCD2 deubiquitination by USP1:WDR48
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786171

USP7 deubiquitinates monoubiquitinated PTEN
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807118

USP13 and OTUD3 deubiquitinate PTEN
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807206

USP9X (FAM) deubiquitinates SMAD4
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-870437

UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853503

UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853514

OTULIN,USP5 cleaves UBC yielding ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853515

OTULIN,USP5 cleaves UBB yielding ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8853529

USP48 cleaves polyubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8862184

OTUD7A hydrolyses K11diUb
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865182

USP4 deubiquitinate TRAF2,TRAF6
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8869456

OTUD3 deubiquitinates PTEN
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8873946

USP8 deubiquitinates LRIG1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875443

USP33 deubiquitinates ROBO1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986083

USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033478

USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033491

USP17L2 deubiquitinates RCE1
type: Axiom
annotated source: GO_0004843
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9653514

GO_0004844
has db xref: Reactome:R-HSA-110215
has db xref: Reactome:R-HSA-110217
has db xref: Reactome:R-HSA-9817512

Cleavage of uracil by UNG glycosylase
type: Axiom
annotated source: GO_0004844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110215

Cleavage of 5-hydroxyluracil by UNG glycosylase
type: Axiom
annotated source: GO_0004844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-110217

UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3
type: Axiom
annotated source: GO_0004844
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9817512

GO_0004849
has db xref: Reactome:R-HSA-8954327

UCKL1 phosphorylates urindine, cytidine
type: Axiom
annotated source: GO_0004849
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8954327

GO_0004850
has db xref: Reactome:R-HSA-74372
has db xref: Reactome:R-HSA-74376

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
type: Axiom
annotated source: GO_0004850
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74372

(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)
type: Axiom
annotated source: GO_0004850
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74376

GO_0004852
has db xref: Reactome:R-HSA-189488

UROS transforms HMB to URO3
type: Axiom
annotated source: GO_0004852
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189488

GO_0004853
has db xref: Reactome:R-HSA-189425
has db xref: Reactome:R-HSA-190182

UROD decarboxylates URO3 to COPRO3
type: Axiom
annotated source: GO_0004853
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189425

UROD decarboxylates URO1 to COPRO1
type: Axiom
annotated source: GO_0004853
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190182

GO_0004854
has db xref: Reactome:R-HSA-9727349

XDH dehydrogenates xanthine to form urate
type: Axiom
annotated source: GO_0004854
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9727349

GO_0004855
has db xref: Reactome:R-HSA-74258
has db xref: Reactome:R-HSA-9748991

XDH oxidizes xanthine to form urate
type: Axiom
annotated source: GO_0004855
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74258

XDH oxidises 6MP to 6TU
type: Axiom
annotated source: GO_0004855
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748991

GO_0004856
has db xref: Reactome:R-HSA-5662466

XYLB phosphorylates D-xylulose
type: Axiom
annotated source: GO_0004856
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5662466

GO_0004861
has db xref: Reactome:R-HSA-187934
has db xref: Reactome:R-HSA-69562

Inactivation of Cyclin A:Cdk2 complexes by p27/p21
type: Axiom
annotated source: GO_0004861
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187934

Inactivation of Cyclin E:Cdk2 complexes by p27/p21
type: Axiom
annotated source: GO_0004861
annotated property: hasDbXref
annotated target: Reactome:R-HSA-69562

GO_0004862
has db xref: Reactome:R-HSA-180073

DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
type: Axiom
annotated source: GO_0004862
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180073

GO_0004867
has db xref: Reactome:R-HSA-158795
has db xref: Reactome:R-HSA-158800
has db xref: Reactome:R-HSA-158893
has db xref: Reactome:R-HSA-159001
has db xref: Reactome:R-HSA-159005

Axiom
annotated source: GO_0004867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158795
label: fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1

Axiom
annotated source: GO_0004867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158800
label: fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
type: Axiom
annotated source: GO_0004867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158893

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
type: Axiom
annotated source: GO_0004867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159001

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
type: Axiom
annotated source: GO_0004867
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159005

GO_0004888
has db xref: Reactome:R-HSA-193672

Sphingomyelinase is activated by the NGF:p75NTR complex
type: Axiom
annotated source: GO_0004888
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193672

GO_0004930
has db xref: Reactome:R-HSA-114552
has db xref: Reactome:R-HSA-114558
has db xref: Reactome:R-HSA-167408

Thrombin-activated PARs activate G12/13
type: Axiom
annotated source: GO_0004930
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114552

Thrombin-activated PARs activate Gq
type: Axiom
annotated source: GO_0004930
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114558

The high affinity receptor complex binds to G-protein
type: Axiom
annotated source: GO_0004930
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167408

GO_0004931
has db xref: Reactome:R-HSA-877187

P2X7 mediates loss of intracellular K+
type: Axiom
annotated source: GO_0004931
annotated property: hasDbXref
annotated target: Reactome:R-HSA-877187

GO_0004965
has db xref: Reactome:R-HSA-1013012
has db xref: Reactome:R-HSA-1013013

Binding of Gbeta/gamma to GIRK/Kir3 channels
type: Axiom
annotated source: GO_0004965
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1013012

Association of GABA B receptor with G protein beta-gamma subunits
type: Axiom
annotated source: GO_0004965
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1013013

GO_0005009
has db xref: Reactome:R-HSA-74715

Autophosphorylation of insulin receptor
type: Axiom
annotated source: GO_0005009
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74715

GO_0005026
has db xref: Reactome:R-HSA-170843

TGFBR2 phosphorylates TGFBR1
type: Axiom
annotated source: GO_0005026
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170843

GO_0005041
has db xref: Reactome:R-HSA-2404131
has db xref: Reactome:R-HSA-2424254

LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
type: Axiom
annotated source: GO_0005041
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2404131

LDLR transports extracellular CR:atREs to cytosol
type: Axiom
annotated source: GO_0005041
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424254

GO_0005049
has db xref: Reactome:R-HSA-178215

SMAD7:SMURF1 complex is exported to the cytosol
type: Axiom
annotated source: GO_0005049
annotated property: hasDbXref
annotated target: Reactome:R-HSA-178215

GO_0005085
has db xref: Reactome:R-HSA-109807
has db xref: Reactome:R-HSA-109817
has db xref: Reactome:R-HSA-114544
has db xref: Reactome:R-HSA-1168636
has db xref: Reactome:R-HSA-1225951
has db xref: Reactome:R-HSA-1225957
has db xref: Reactome:R-HSA-1250383
has db xref: Reactome:R-HSA-1250463
has db xref: Reactome:R-HSA-1250498
has db xref: Reactome:R-HSA-1306972
has db xref: Reactome:R-HSA-1433415
has db xref: Reactome:R-HSA-1433471
has db xref: Reactome:R-HSA-156913
has db xref: Reactome:R-HSA-169904
has db xref: Reactome:R-HSA-170979
has db xref: Reactome:R-HSA-171026
has db xref: Reactome:R-HSA-177938
has db xref: Reactome:R-HSA-177945
has db xref: Reactome:R-HSA-180687
has db xref: Reactome:R-HSA-186834
has db xref: Reactome:R-HSA-187746
has db xref: Reactome:R-HSA-194518
has db xref: Reactome:R-HSA-2029445
has db xref: Reactome:R-HSA-2029451
has db xref: Reactome:R-HSA-2029467
has db xref: Reactome:R-HSA-203977
has db xref: Reactome:R-HSA-205039
has db xref: Reactome:R-HSA-210977
has db xref: Reactome:R-HSA-2179407
has db xref: Reactome:R-HSA-2424476
has db xref: Reactome:R-HSA-2424477
has db xref: Reactome:R-HSA-2485180
has db xref: Reactome:R-HSA-2730840
has db xref: Reactome:R-HSA-350769
has db xref: Reactome:R-HSA-354173
has db xref: Reactome:R-HSA-379044
has db xref: Reactome:R-HSA-379048
has db xref: Reactome:R-HSA-380073
has db xref: Reactome:R-HSA-389348
has db xref: Reactome:R-HSA-389350
has db xref: Reactome:R-HSA-392054
has db xref: Reactome:R-HSA-392195
has db xref: Reactome:R-HSA-3928592
has db xref: Reactome:R-HSA-3928612
has db xref: Reactome:R-HSA-3928628
has db xref: Reactome:R-HSA-3928632
has db xref: Reactome:R-HSA-3928633
has db xref: Reactome:R-HSA-3928642
has db xref: Reactome:R-HSA-3928651
has db xref: Reactome:R-HSA-392870
has db xref: Reactome:R-HSA-3965444
has db xref: Reactome:R-HSA-399938
has db xref: Reactome:R-HSA-399995
has db xref: Reactome:R-HSA-4093336
has db xref: Reactome:R-HSA-416530
has db xref: Reactome:R-HSA-416588
has db xref: Reactome:R-HSA-418579
has db xref: Reactome:R-HSA-418850
has db xref: Reactome:R-HSA-418856
has db xref: Reactome:R-HSA-419166
has db xref: Reactome:R-HSA-420883
has db xref: Reactome:R-HSA-428535
has db xref: Reactome:R-HSA-428750
has db xref: Reactome:R-HSA-428917
has db xref: Reactome:R-HSA-442273
has db xref: Reactome:R-HSA-442291
has db xref: Reactome:R-HSA-442314
has db xref: Reactome:R-HSA-442732
has db xref: Reactome:R-HSA-445064
has db xref: Reactome:R-HSA-5218829
has db xref: Reactome:R-HSA-5218839
has db xref: Reactome:R-HSA-5218850
has db xref: Reactome:R-HSA-5617816
has db xref: Reactome:R-HSA-5623508
has db xref: Reactome:R-HSA-5623521
has db xref: Reactome:R-HSA-5637806
has db xref: Reactome:R-HSA-5637808
has db xref: Reactome:R-HSA-5654392
has db xref: Reactome:R-HSA-5654402
has db xref: Reactome:R-HSA-5654413

GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109807

GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109817

p115-RhoGEF activation of RHOA
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-114544

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168636

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1225951

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1225957

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250383

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250463

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1250498

RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1306972

Activation of RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433415

Activation of RAS by p-KIT bound SOS1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1433471

Regeneration of eEF1A:GTP by eEF1B activity
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-156913

C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169904

(Frs2)C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170979

Guanine nucleotide exchange on RAL
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-171026

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177938

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177945

Conversion of Ran-GDP to Ran-GTP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-180687

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-186834

RIT/RIN are activated
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-187746

RhoA is activated by nucleotide exchange and inhibits axonal growth
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194518

An unknown GEF exchanges GTP for GDP on CDC42:GDP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029445

Activation of RAC1 by VAV
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029451

Activation of RAC1 by CRKII:DOCK180:ELMO
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029467

SAR1 Activation And Membrane Binding
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203977

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205039

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210977

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2179407

Activation of RAC1 by VAV2/3
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424476

SOS mediated nucleotide exchange of RAS (SHC)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2424477

MII catalyses GDP/GTP exchange on Gt
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2485180

Activation of RAC1 by VAV
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730840

trans-Golgi Network Coat Activation
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-350769

Activation of Rap1 by cytosolic GEFs
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-354173

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379044

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379048

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380073

Activation of Rac1 by pVav1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389348

Activation of Cdc42 by pVav1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389350

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392054

Gi activation by P2Y purinoceptor 12
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392195

p190RhoGEF exchanges GTP for GDP on RHOA, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928592

KALRN exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928612

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928628

ITSN1 exchanges GTP for GDP on CDC42, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928632

bPIX exchanges GTP for GDP on RAC, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928633

TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928642

NGEF exchanges GTP for GDP on RHOA
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928651

Gs activation by prostacyclin receptor
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392870

WNT:FZD complex promotes G-protein nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3965444

Activation of Rac1 by FARP2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399938

Muscarinic Acetylcholine Receptor M3 activates Gq
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399995

p-TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4093336

FFAR1:FFAR1 ligands activates Gq
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416530

Activation of Rho by LARG and PDZ-RhoGEF
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416588

Gq activation by P2Y purinoceptor 1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418579

Activation of Cdc42
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418850

Activation of Rac1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418856

GEFs activate RhoA,B,C
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-419166

Opsins act as GEFs for G alpha-t
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-420883

Activation of RAC1 by SOS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428535

Gq activation by TP receptor
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428750

G13 activation by TP receptor
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428917

VAV1 is a GEF for Rho/Rac family GTPases
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442273

VAV2 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442291

VAV3 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442314

NMDA-activated RASGRF1 activates RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442732

Activation of Rac1 by VAV2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-445064

VEGF induces CDC42 activation by unknown mechanism
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218829

DOCK180:ELMO exchanges GTP for GDP, activating RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218839

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5218850

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5617816

GBF1 stimulates nucleotide exchange on ARF4
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623508

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623521

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5637806

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5637808

Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654392

Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654402

Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654413

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654426

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654600

Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654618

Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654647

Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654663

Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655241

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655277

Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655326

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655347

RAS GEFs promote RAS nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5672965

GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686071

GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5686318

Nucleotide exchange on RAB1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694409

GBF1 stimulates ARF nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807868

GBF1 stimulates nucleotide exchange on ARF
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6811414

ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6811418

RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6811429

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-749453

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-751029

Glucagon:GCGR mediates GTP-GDP exchange
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-825631

Activation of RAC1 by the PXN:CRK complex
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848618

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8850041

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851827

RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851877

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8851899

RAB3 GEFs exchange GTP for GDP on RAB3A
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875318

RAB5 GEFs exchange GTP for GDP on RAB5
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875320

RAPGEF1 activates RAP1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875568

DOCK7 activates RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875591

DENND4s exchange GTP for GDP on RAB10
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876188

RAB8 GEFs exchange GTP for GDP on RAB8
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876190

RAB9 GEFs exchange GTP for GDP on RAB9
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876191

RIC1-RGP1 exchanges GTP for GDP on RAB6
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876193

DENND3 exchanges GTP for GDP on RAB12
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876454

RAB13 GEFs exchange GTP for GDP on RAB13
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876615

DENND6A,B exchange GTP for GDP on RAB14
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876616

RAB21 GEFs exchange GTP for GDP on RAB21
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876837

MADD exchanges GTP for GDP on RAB27
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877308

RAB31 GEFs exchange GTP for GDP on RAB31
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877311

MON1:CCZ1 exchanges GTP for GDP on RAB7
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877451

TRAPPC complexes exchange GTP for GDP on RAB1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877475

DENND1s exchange GTP for GDP on RAB35
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877612

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877760

DENND5A,B exchange GTP for GDP on RAB39
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877813

RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8877998

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8964604

RHOA GEFs activate RHOA
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8980691

Opsins binds G alpha-t
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982637

G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8982640

RHOB GEFs activate RHOB
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013023

RHOC GEFs activate RHOC
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013109

RAC1 GEFs activate RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013143

CDC42 GEFs activate CDC42
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013159

RHOD auto-activates
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013435

RAC2 GEFs activate RAC2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9014296

RHOG GEFs activate RHOG
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9014433

RHOJ GEFs activate RHOJ
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9017491

RHOQ GEFs activate RHOQ
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018747

RHOU auto-activates
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018768

RAC3 GEFs activate RAC3
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018804

RHOT1 GEFs activate RHOT1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018817

RHOT2 GEFs activate RHOT2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018825

NTRK2 activates RAS signaling through SHC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9026891

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9029158

NTRK2 activates RAS signaling through FRS2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032067

DOCK3 activates RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9032798

NTRK2 and CDK5 promote activation of RAC1 by TIAM1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033292

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036301

Activation of Rap1 by membrane-associated GEFs
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-939265

SOS1-mediated nucleotide exchange of RAS downstream of FLT3
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9607304

p-S516-ARHGEF7 activates RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9619803

RCC1 stimulates GDP to GTP exchange on RAN
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624845

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9634418

RRAGC,D exchanges GTP for GDP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9639286

RRAGA,B exchanges GDP for GTP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9640167

ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9660824

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664991

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665009

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665404

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665408

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665700

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9665707

DOCK180 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9666428

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9666430

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9670436

SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9672163

SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9672170

CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9680385

RHOF auto-activates
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9693111

FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9695853

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9703441

p-VAV1,2,3 exchange 6TGTP for GDP on RAC1
type: Axiom
annotated source: GO_0005085
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9751201

GO_0005096
has db xref: Reactome:R-HSA-392513
has db xref: Reactome:R-HSA-399935
has db xref: Reactome:R-HSA-4093339
has db xref: Reactome:R-HSA-416546
has db xref: Reactome:R-HSA-416559
has db xref: Reactome:R-HSA-428522
has db xref: Reactome:R-HSA-428533
has db xref: Reactome:R-HSA-5638007
has db xref: Reactome:R-HSA-8981637
has db xref: Reactome:R-HSA-8985594
has db xref: Reactome:R-HSA-9013022
has db xref: Reactome:R-HSA-9013111
has db xref: Reactome:R-HSA-9013144
has db xref: Reactome:R-HSA-9013161
has db xref: Reactome:R-HSA-9013437
has db xref: Reactome:R-HSA-9014295
has db xref: Reactome:R-HSA-9014434
has db xref: Reactome:R-HSA-9017488
has db xref: Reactome:R-HSA-9018745
has db xref: Reactome:R-HSA-9018806
has db xref: Reactome:R-HSA-9624893
has db xref: Reactome:R-HSA-9693282

Rap1 signal termination by Rap1GAPs
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-392513

Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399935

p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4093339

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416546

Inactivation of Rho-GTP by p190RhoGAP
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-416559

Inactivation of RAC1
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428522

Inactivation of CDC42
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428533

RP2 activates the GTPase activity of ARL3
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5638007

RHOA GAPs stimulate RHOA GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8981637

MYO9B inactivates RHOA
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8985594

RHOB GAPs stimulate RHOB GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013022

RHOC GAPs stimulate RHOC GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013111

RAC1 GAPs stimulate RAC1 GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013144

CDC42 GAPs stimulate CDC42 GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013161

RHOD GAPs stimulate RHOD GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013437

RAC2 GAPs stimulate RAC2 GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9014295

RHOG GAPs stimulate RHOG GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9014434

RHOJ GAPs stimulate RHOJ GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9017488

RHOQ GAPs stimulate RHOQ GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018745

RAC3 GAPs stimulate RAC3 GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9018806

RAN stimulates fusion of nuclear envelope (NE) membranes
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9624893

RHOF GAPs stimulate RHOF GTPase activity
type: Axiom
annotated source: GO_0005096
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9693282

GO_0005219
has db xref: Reactome:R-HSA-2855020

RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
type: Axiom
annotated source: GO_0005219
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2855020

GO_0005221
has db xref: Reactome:R-HSA-2514867

cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
type: Axiom
annotated source: GO_0005221
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514867

GO_0005225
has db xref: Reactome:R-HSA-8941543

VRAC heteromer transports I-, Cl- from cytosol to extracellular region
type: Axiom
annotated source: GO_0005225
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8941543

GO_0005227
has db xref: Reactome:R-HSA-9717383

TRPM4 transports Na+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005227
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717383

GO_0005229
has db xref: Reactome:R-HSA-2684901
has db xref: Reactome:R-HSA-2744242
has db xref: Reactome:R-HSA-2744361
has db xref: Reactome:R-HSA-9659568

ANOs transport cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005229
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2684901

TTYH2/3 transport cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005229
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2744242

BESTs transport cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005229
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2744361

ANO1 transports cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005229
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9659568

GO_0005231
has db xref: Reactome:R-HSA-399711
has db xref: Reactome:R-HSA-399712
has db xref: Reactome:R-HSA-420980
has db xref: Reactome:R-HSA-432164
has db xref: Reactome:R-HSA-438037

Activation of Ca impermeable AMPA receptors
type: Axiom
annotated source: GO_0005231
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399711

Activation of Ca permeable AMPA receptors
type: Axiom
annotated source: GO_0005231
annotated property: hasDbXref
annotated target: Reactome:R-HSA-399712

Activation of Ca permeable AMPA receptors
type: Axiom
annotated source: GO_0005231
annotated property: hasDbXref
annotated target: Reactome:R-HSA-420980

Ca2+ influx into the post-synaptic cell
type: Axiom
annotated source: GO_0005231
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432164

Membrane depolarization upon activation of Ca impermeable AMPA receptors
type: Axiom
annotated source: GO_0005231
annotated property: hasDbXref
annotated target: Reactome:R-HSA-438037

GO_0005242
has db xref: Reactome:R-HSA-1296045
has db xref: Reactome:R-HSA-1296046
has db xref: Reactome:R-HSA-1369017
has db xref: Reactome:R-HSA-5678261
has db xref: Reactome:R-HSA-5678418
has db xref: Reactome:R-HSA-9729870
has db xref: Reactome:R-HSA-9730521
has db xref: Reactome:R-HSA-9731072

Activation of Potassium transport channels
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296045

KCNJs transport K+ from the extracellular region to cytosol
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296046

Activation of ATP sensitive Potassium channels in muscle cells
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1369017

KCNJ11:ABCC9 transports K+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5678261

Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5678418

KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9729870

SARS-CoV-2 3a induces potassium efflux
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9730521

SARS-CoV-1 3a tetramer induces potassium efflux
type: Axiom
annotated source: GO_0005242
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9731072

GO_0005243
has db xref: Reactome:R-HSA-190681
has db xref: Reactome:R-HSA-375330
has db xref: Reactome:R-HSA-375339
has db xref: Reactome:R-HSA-375340
has db xref: Reactome:R-HSA-375342

Connexin oligomerization in endoplasmic reticulum membrane
type: Axiom
annotated source: GO_0005243
annotated property: hasDbXref
annotated target: Reactome:R-HSA-190681

Connexin 45/Connexin 36 mediated neuronal gap junction communication
type: Axiom
annotated source: GO_0005243
annotated property: hasDbXref
annotated target: Reactome:R-HSA-375330

Pannexin 1/Pannexin2 mediated neuronal gap junction communication
type: Axiom
annotated source: GO_0005243
annotated property: hasDbXref
annotated target: Reactome:R-HSA-375339

Connexin 62 mediated neuronal gap junction communication
type: Axiom
annotated source: GO_0005243
annotated property: hasDbXref
annotated target: Reactome:R-HSA-375340

Connexin 36 mediated neuronal gap junction communication
type: Axiom
annotated source: GO_0005243
annotated property: hasDbXref
annotated target: Reactome:R-HSA-375342

GO_0005245
has db xref: Reactome:R-HSA-265645
has db xref: Reactome:R-HSA-5577213
has db xref: Reactome:R-HSA-9701055
has db xref: Reactome:R-HSA-9701141

Calcium Influx through Voltage-gated Calcium Channels
type: Axiom
annotated source: GO_0005245
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265645

LTCC multimer transports Ca2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005245
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5577213

TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005245
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9701055

TRPV1 transports Ca2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005245
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9701141

GO_0005247
has db xref: Reactome:R-HSA-2744228

CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005247
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2744228

GO_0005248
has db xref: Reactome:R-HSA-5576895

SCNAs:SNCBs transport Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005248
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5576895

GO_0005249
has db xref: Reactome:R-HSA-1296127
has db xref: Reactome:R-HSA-9659554
has db xref: Reactome:R-HSA-9667761

Activation of voltage gated Potassium channels
type: Axiom
annotated source: GO_0005249
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296127

KCNQ4 transports K+ from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005249
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9659554

KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005249
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9667761

GO_0005250
has db xref: Reactome:R-HSA-5577234

KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005250
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5577234

GO_0005251
has db xref: Reactome:R-HSA-5577050
has db xref: Reactome:R-HSA-5577237

AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005251
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5577050

KCNH2:KCNE transport K+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005251
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5577237

GO_0005253
has db xref: Reactome:R-HSA-432034
has db xref: Reactome:R-HSA-432036

Aquaporin-6 passively transports anions into vesicles
type: Axiom
annotated source: GO_0005253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432034

Aquaporin-6 passively transports anions out of vesicles
type: Axiom
annotated source: GO_0005253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-432036

GO_0005254
has db xref: Reactome:R-HSA-2744349
has db xref: Reactome:R-HSA-427570
has db xref: Reactome:R-HSA-9712204
has db xref: Reactome:R-HSA-975340
has db xref: Reactome:R-HSA-975449

TTYH1 transports cytosolic Cl- to extracellular region
type: Axiom
annotated source: GO_0005254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2744349

Group 3 - Selective Cl- transport
type: Axiom
annotated source: GO_0005254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427570

ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712204

GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol
type: Axiom
annotated source: GO_0005254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975340

GABRR pentamers:GABA transports extracellular Cl- to cytosol
type: Axiom
annotated source: GO_0005254
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975449

GO_0005261
has db xref: Reactome:R-HSA-1168376
has db xref: Reactome:R-HSA-1296043
has db xref: Reactome:R-HSA-169683
has db xref: Reactome:R-HSA-2089943
has db xref: Reactome:R-HSA-426223
has db xref: Reactome:R-HSA-4420052
has db xref: Reactome:R-HSA-9706720
has db xref: Reactome:R-HSA-9712190
has db xref: Reactome:R-HSA-9754616
has db xref: Reactome:R-HSA-9837835

STIM1 oligomerizes
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1168376

Activation of HCN channels
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296043

IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-169683

TRPC1 translocates calcium from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2089943

Cation influx mediated by TRPC3/6/7
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-426223

Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4420052

SARS-CoV-1 E transports Ca2+
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9706720

cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9712190

SARS-CoV-2 E pentamer transports Ca2+
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9754616

SH pentamer transports K+
type: Axiom
annotated source: GO_0005261
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9837835

GO_0005262
has db xref: Reactome:R-HSA-139854
has db xref: Reactome:R-HSA-139855
has db xref: Reactome:R-HSA-210420
has db xref: Reactome:R-HSA-3295579
has db xref: Reactome:R-HSA-8949145
has db xref: Reactome:R-HSA-8949178
has db xref: Reactome:R-HSA-9663785

IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139854

P2X1-mediated entry of Ca++ from plasma
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-139855

Ca2+ influx through voltage gated Ca2+ channels
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210420

TRPs transport extracellular Ca2+ to cytosol
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3295579

VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949145

MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949178

CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005262
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9663785

GO_0005267
has db xref: Reactome:R-HSA-1296024
has db xref: Reactome:R-HSA-1296035
has db xref: Reactome:R-HSA-1296037
has db xref: Reactome:R-HSA-1296039
has db xref: Reactome:R-HSA-1296348
has db xref: Reactome:R-HSA-1299297
has db xref: Reactome:R-HSA-1299304
has db xref: Reactome:R-HSA-1299318
has db xref: Reactome:R-HSA-1299338
has db xref: Reactome:R-HSA-1299359
has db xref: Reactome:R-HSA-2534365
has db xref: Reactome:R-HSA-5578910

Activation of ATP sensitive Potassium channels in neuroendocrine cells
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296024

Activation of Ca2+ activated Potassium channels with Intermediate conductance
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296035

Activation of Ca2+ activated Potassium channels with large conductance
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296037

Activation of Ca2+ activated Potassium channels with small conductance
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296039

Activation of TWIK-related K+ channel (TREK)
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1296348

Activation of THIK
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299297

Activation of tandem pore domain in a weak inwardly rectifying K+ channels
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299304

Activation of TASK
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299318

Activation of TRESK
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299338

Activation of TALK
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299359

Slo3 Potassium Transport
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2534365

KCNK dimers transport K+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005267
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5578910

GO_0005272
has db xref: Reactome:R-HSA-2730664
has db xref: Reactome:R-HSA-3295580
has db xref: Reactome:R-HSA-9717374
has db xref: Reactome:R-HSA-9717382
has db xref: Reactome:R-HSA-9717395
has db xref: Reactome:R-HSA-9717396

UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730664

TRPM4,5 transport extracellular Na+ to cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3295580

SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717374

SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717382

TRPM5 transports Na+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717395

SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005272
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717396

GO_0005277
has db xref: Reactome:R-HSA-264615

Loading of acetylcholine in synaptic vesicles
type: Axiom
annotated source: GO_0005277
annotated property: hasDbXref
annotated target: Reactome:R-HSA-264615

GO_0005280
has db xref: Reactome:R-HSA-8875623

SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix
type: Axiom
annotated source: GO_0005280
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8875623

GO_0005298
has db xref: Reactome:R-HSA-444100

PROT mediates L-proline uptake
type: Axiom
annotated source: GO_0005298
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444100

GO_0005309
has db xref: Reactome:R-HSA-200396

Creatine transport across the plasma membrane
type: Axiom
annotated source: GO_0005309
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200396

GO_0005310
has db xref: Reactome:R-HSA-1614546
has db xref: Reactome:R-HSA-372843

Sulfate is exported to the cytosol in exchange for dicarboxylate
type: Axiom
annotated source: GO_0005310
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1614546

SLC25A10 mediates exchange of malate and phosphate
type: Axiom
annotated source: GO_0005310
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372843

GO_0005313
has db xref: Reactome:R-HSA-210444
has db xref: Reactome:R-HSA-428052
has db xref: Reactome:R-HSA-5624256

L-Glutamate loading of synaptic vesicle
type: Axiom
annotated source: GO_0005313
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210444

SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+
type: Axiom
annotated source: GO_0005313
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428052

Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+
type: Axiom
annotated source: GO_0005313
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5624256

GO_0005314
has db xref: Reactome:R-HSA-210404
has db xref: Reactome:R-HSA-428015
has db xref: Reactome:R-HSA-5625015
has db xref: Reactome:R-HSA-5625029

SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+
type: Axiom
annotated source: GO_0005314
annotated property: hasDbXref
annotated target: Reactome:R-HSA-210404

SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005314
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428015

Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005314
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5625015

SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005314
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5625029

GO_0005319
has db xref: Reactome:R-HSA-1369028
has db xref: Reactome:R-HSA-1369052
has db xref: Reactome:R-HSA-174786
has db xref: Reactome:R-HSA-5682285
has db xref: Reactome:R-HSA-5682311
has db xref: Reactome:R-HSA-5683672
has db xref: Reactome:R-HSA-5683714
has db xref: Reactome:R-HSA-5688397
has db xref: Reactome:R-HSA-6801250
has db xref: Reactome:R-HSA-8848053
has db xref: Reactome:R-HSA-8866329

ABCAs mediate lipid efflux
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1369028

ABCAs mediate lipid influx
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1369052

ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174786

ABCA12 transports lipids from cytosol to extracellular region
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682285

Defective ABCA12 does not transport lipids from cytosol to extracellular region
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5682311

Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683672

ABCA3 transports PC, PG from ER membrane to lamellar body
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5683714

Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5688397

TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801250

ABCA5 transports CHOL from lysosomal lumen to cytosol
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8848053

MTTP lipidates APOB-100, forming a pre-VLDL
type: Axiom
annotated source: GO_0005319
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8866329

GO_0005324
has db xref: Reactome:R-HSA-2046087
has db xref: Reactome:R-HSA-2046093
has db xref: Reactome:R-HSA-382575
has db xref: Reactome:R-HSA-390393
has db xref: Reactome:R-HSA-434381
has db xref: Reactome:R-HSA-5684043

Translocation of tetracosahexaenoyl-CoA to peroxisomes
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046087

Translocation of tetracosapentaenoyl-CoA to peroxisomes
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2046093

ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-382575

Peroxisomal uptake of very long-chain fatty acyl CoA
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390393

CD36 (FAT) translocates palmitate from the extracellular region to the cytosol
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-434381

Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix
type: Axiom
annotated source: GO_0005324
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684043

GO_0005326
has db xref: Reactome:R-HSA-374896
has db xref: Reactome:R-HSA-374919

Uptake of Noradrenaline
type: Axiom
annotated source: GO_0005326
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374896

Noradrenaline clearance from the synaptic cleft
type: Axiom
annotated source: GO_0005326
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374919

GO_0005332
has db xref: Reactome:R-HSA-444007

GAT1-3 mediate Na+/Cl- dependent GABA transport
type: Axiom
annotated source: GO_0005332
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444007

GO_0005334
has db xref: Reactome:R-HSA-443997
has db xref: Reactome:R-HSA-5659764

SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005334
annotated property: hasDbXref
annotated target: Reactome:R-HSA-443997

Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005334
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5659764

GO_0005335
has db xref: Reactome:R-HSA-444008

SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005335
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444008

GO_0005337
has db xref: Reactome:R-HSA-109527
has db xref: Reactome:R-HSA-109529
has db xref: Reactome:R-HSA-109534
has db xref: Reactome:R-HSA-109536
has db xref: Reactome:R-HSA-5628807
has db xref: Reactome:R-HSA-727740
has db xref: Reactome:R-HSA-727749
has db xref: Reactome:R-HSA-727767
has db xref: Reactome:R-HSA-727768
has db xref: Reactome:R-HSA-9751024
has db xref: Reactome:R-HSA-9754929
has db xref: Reactome:R-HSA-9755015
has db xref: Reactome:R-HSA-9755035

Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109527

Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109529

Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109534

Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109536

Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5628807

Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727740

SLC29A3 transports nucleosides from lysosomal lumen to cytosol
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727749

SLC29A3 transports nucleosides from cytosol to lysosomal lumen
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727767

Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727768

SLC29A1,2 transport 6MP from extracellular region to cytosol
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9751024

SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9754929

SLC29A1 transports RBV from extracellular region to cytosol
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755015

SLC29A1 transports RBV from cytosol to extracellular region
type: Axiom
annotated source: GO_0005337
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755035

GO_0005338
has db xref: Reactome:R-HSA-744230
has db xref: Reactome:R-HSA-744231
has db xref: Reactome:R-HSA-9792608

SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP
type: Axiom
annotated source: GO_0005338
annotated property: hasDbXref
annotated target: Reactome:R-HSA-744230

SLC35D2 exchanges UDP-GlcNAc for UMP
type: Axiom
annotated source: GO_0005338
annotated property: hasDbXref
annotated target: Reactome:R-HSA-744231

SLC35D2 exchanges UDP-D-glucose for UMP
type: Axiom
annotated source: GO_0005338
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9792608

GO_0005343
has db xref: Reactome:R-HSA-8876312

SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
type: Axiom
annotated source: GO_0005343
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8876312

GO_0005347
has db xref: Reactome:R-HSA-9717392

CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005347
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9717392

GO_0005353
has db xref: Reactome:R-HSA-189222

SLC2A5 transports fructose from extracellular region to cytosol
type: Axiom
annotated source: GO_0005353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189222

GO_0005355
has db xref: Reactome:R-HSA-499981
has db xref: Reactome:R-HSA-5653873

Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2
type: Axiom
annotated source: GO_0005355
annotated property: hasDbXref
annotated target: Reactome:R-HSA-499981

SLC2A1 tetramer transports Glc from cytosol to Golgi lumen
type: Axiom
annotated source: GO_0005355
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653873

GO_0005362
has db xref: Reactome:R-HSA-429567

Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4
type: Axiom
annotated source: GO_0005362
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429567

GO_0005366
has db xref: Reactome:R-HSA-429101

HMIT co-transports myo-inositol with a proton
type: Axiom
annotated source: GO_0005366
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429101

GO_0005367
has db xref: Reactome:R-HSA-429663

SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005367
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429663

GO_0005375
has db xref: Reactome:R-HSA-437300

SLC31A1 transports Cu2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437300

GO_0005381
has db xref: Reactome:R-HSA-435349
has db xref: Reactome:R-HSA-5623558
has db xref: Reactome:R-HSA-5655733
has db xref: Reactome:R-HSA-904830
has db xref: Reactome:R-HSA-917936

SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-435349

Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623558

Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655733

SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-904830

MCOLN1 transports Fe2+ from endosome lumen to cytosol
type: Axiom
annotated source: GO_0005381
annotated property: hasDbXref
annotated target: Reactome:R-HSA-917936

GO_0005384
has db xref: Reactome:R-HSA-8959798

SLC30A10 transports Mn2+ from cytosol to extracellular region
type: Axiom
annotated source: GO_0005384
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8959798

GO_0005385
has db xref: Reactome:R-HSA-435366
has db xref: Reactome:R-HSA-435375
has db xref: Reactome:R-HSA-437084
has db xref: Reactome:R-HSA-437085
has db xref: Reactome:R-HSA-437136
has db xref: Reactome:R-HSA-437139
has db xref: Reactome:R-HSA-442317
has db xref: Reactome:R-HSA-442345
has db xref: Reactome:R-HSA-442387
has db xref: Reactome:R-HSA-442393
has db xref: Reactome:R-HSA-442405
has db xref: Reactome:R-HSA-442422
has db xref: Reactome:R-HSA-5654125
has db xref: Reactome:R-HSA-9820566

ZnT1 mediates the efflux of zinc from the cell
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-435366

ZnT2 facilitates zinc vesicular sequestration
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-435375

ZnT3 transports zinc into synaptic vesicles
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437084

ZnT5 transports zinc into secretory granules in pancreatic beta cells
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437085

SLC30A8 transports Zn2+ from cytosol to secretory granule
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437136

ZnT8 transports zinc into the Golgi apparatus
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-437139

ZIP6 and ZIP14 mediate zinc influx into cells
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442317

hZIP10 mediates zinc influx into cells
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442345

ZIP8 mediates zinc influx into cells
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442387

ZIP7 mediates zinc efflux from the endoplasmic reticulum
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442393

hZIP5 mediates zinc uptake by cells
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442405

SLC39A1-4 transports Zn2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442422

Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5654125

ZnT5 transports zinc into the golgi apparatus
type: Axiom
annotated source: GO_0005385
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9820566

GO_0005388
has db xref: Reactome:R-HSA-418309
has db xref: Reactome:R-HSA-418365
has db xref: Reactome:R-HSA-427910
has db xref: Reactome:R-HSA-936883
has db xref: Reactome:R-HSA-9662114
has db xref: Reactome:R-HSA-9664214

ATP2B1-4 transport cytosolic Ca2+ to extracellular region
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418309

ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-418365

ATP2A1-3 transport Ca2+ from cytosol to ER lumen
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427910

ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936883

ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9662114

ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region
type: Axiom
annotated source: GO_0005388
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9664214

GO_0005391
has db xref: Reactome:R-HSA-936897

ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
type: Axiom
annotated source: GO_0005391
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936897

GO_0005412
has db xref: Reactome:R-HSA-189208
has db xref: Reactome:R-HSA-429613
has db xref: Reactome:R-HSA-5656356
has db xref: Reactome:R-HSA-5658163
has db xref: Reactome:R-HSA-8932955

SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
type: Axiom
annotated source: GO_0005412
annotated property: hasDbXref
annotated target: Reactome:R-HSA-189208

SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005412
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429613

Defective SLC5A1 does not cotransport Glc and Na+
type: Axiom
annotated source: GO_0005412
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656356

Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005412
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5658163

SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005412
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8932955

GO_0005415
has db xref: Reactome:R-HSA-109530
has db xref: Reactome:R-HSA-109538
has db xref: Reactome:R-HSA-109539
has db xref: Reactome:R-HSA-9751037
has db xref: Reactome:R-HSA-9754934

Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
type: Axiom
annotated source: GO_0005415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109530

Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
type: Axiom
annotated source: GO_0005415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109538

Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
type: Axiom
annotated source: GO_0005415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109539

SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9751037

SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005415
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9754934

GO_0005432
has db xref: Reactome:R-HSA-425661
has db xref: Reactome:R-HSA-8949688
has db xref: Reactome:R-HSA-8949703

SLC8A1,2,3 exchange 3Na+ for Ca2+
type: Axiom
annotated source: GO_0005432
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425661

SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
type: Axiom
annotated source: GO_0005432
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949688

SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)
type: Axiom
annotated source: GO_0005432
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8949703

GO_0005436
has db xref: Reactome:R-HSA-2872498
has db xref: Reactome:R-HSA-427605
has db xref: Reactome:R-HSA-427645
has db xref: Reactome:R-HSA-427656
has db xref: Reactome:R-HSA-428609
has db xref: Reactome:R-HSA-5625123
has db xref: Reactome:R-HSA-5651685
has db xref: Reactome:R-HSA-5651697
has db xref: Reactome:R-HSA-5651971
has db xref: Reactome:R-HSA-5687585

SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2872498

SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427605

SLC34A3 cotransports Pi, 2Na+
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427645

SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427656

Type I Na+-coupled phosphate co-transport
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428609

Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5625123

Defective SLC34A1 does not cotransport Pi, 3Na+
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651685

Defective SLC34A2 does not cotransport Pi, 3Na+
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651697

Defective SLC34A3 does not cotransport Pi, 2Na+
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651971

Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0005436
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5687585

GO_0005452
has db xref: Reactome:R-HSA-1237038
has db xref: Reactome:R-HSA-1247665
has db xref: Reactome:R-HSA-425482
has db xref: Reactome:R-HSA-425577
has db xref: Reactome:R-HSA-427666
has db xref: Reactome:R-HSA-5627737
has db xref: Reactome:R-HSA-5656248

SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237038

SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1247665

SLC4A1,2,3 exchanges HCO3- for Cl-
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425482

Na+-driven Cl-/HCO3- exchanger transport
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425577

SLC26A3,6 exchange Cl- for HCO3-
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-427666

SLC26A3 does not exchange Cl- for HCO3-
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5627737

Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes)
type: Axiom
annotated source: GO_0005452
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656248

GO_0005456
has db xref: Reactome:R-HSA-5651942
has db xref: Reactome:R-HSA-727807

Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP
type: Axiom
annotated source: GO_0005456
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5651942

SLC35A1 exchanges CMP-Neu5Ac for CMP
type: Axiom
annotated source: GO_0005456
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727807

GO_0005457
has db xref: Reactome:R-HSA-5653596
has db xref: Reactome:R-HSA-742345

Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen
type: Axiom
annotated source: GO_0005457
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653596

SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen
type: Axiom
annotated source: GO_0005457
annotated property: hasDbXref
annotated target: Reactome:R-HSA-742345

GO_0005459
has db xref: Reactome:R-HSA-5652099
has db xref: Reactome:R-HSA-735702

Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP
type: Axiom
annotated source: GO_0005459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5652099

SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP
type: Axiom
annotated source: GO_0005459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-735702

GO_0005461
has db xref: Reactome:R-HSA-174368
has db xref: Reactome:R-HSA-5603297

SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen
type: Axiom
annotated source: GO_0005461
annotated property: hasDbXref
annotated target: Reactome:R-HSA-174368

Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc
type: Axiom
annotated source: GO_0005461
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603297

GO_0005462
has db xref: Reactome:R-HSA-5653622
has db xref: Reactome:R-HSA-741450
has db xref: Reactome:R-HSA-742354

Defective SLC35A3 does not exchange UDP-GlcNAc for UMP
type: Axiom
annotated source: GO_0005462
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5653622

SLC35A3 exchanges UDP-GlcNAc for UMP
type: Axiom
annotated source: GO_0005462
annotated property: hasDbXref
annotated target: Reactome:R-HSA-741450

SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen
type: Axiom
annotated source: GO_0005462
annotated property: hasDbXref
annotated target: Reactome:R-HSA-742354

GO_0005464
has db xref: Reactome:R-HSA-742373

SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen
type: Axiom
annotated source: GO_0005464
annotated property: hasDbXref
annotated target: Reactome:R-HSA-742373

GO_0005501
has db xref: Reactome:R-HSA-2454113
has db xref: Reactome:R-HSA-2464809
has db xref: Reactome:R-HSA-2465934
has db xref: Reactome:R-HSA-2465938

RBP3 transports 11cRAL to rod photoreceptor outer segment
type: Axiom
annotated source: GO_0005501
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2454113

RBP3 regulates the transport of atROL from ROS to RPE
type: Axiom
annotated source: GO_0005501
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2464809

11cROL translocates from Muller cells to cone photoreceptor cells
type: Axiom
annotated source: GO_0005501
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2465934

RBP3 regulates atROL taken up by Muller cells
type: Axiom
annotated source: GO_0005501
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2465938

GO_0005524
has db xref: Reactome:R-HSA-265682

KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
type: Axiom
annotated source: GO_0005524
annotated property: hasDbXref
annotated target: Reactome:R-HSA-265682

GO_0005525
has db xref: Reactome:R-HSA-167429

The receptor:G-protein complex binds GTP
type: Axiom
annotated source: GO_0005525
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167429

GO_0005537
has db xref: Reactome:R-HSA-947991

Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi
type: Axiom
annotated source: GO_0005537
annotated property: hasDbXref
annotated target: Reactome:R-HSA-947991

GO_0005548
has db xref: Reactome:R-HSA-216757
has db xref: Reactome:R-HSA-382553
has db xref: Reactome:R-HSA-5678706
has db xref: Reactome:R-HSA-5678749
has db xref: Reactome:R-HSA-8857662
has db xref: Reactome:R-HSA-8865637
has db xref: Reactome:R-HSA-8867876

4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-216757

ABCA7:Apo1A-mediated phospholipid efflux
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-382553

ABCB4 transports PC from plasma membrane to extracellular region
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5678706

Defective ABCB4 does not transport PC from plasma membrane to extracellular region
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5678749

ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8857662

MFSD2A transports LPC from extracellular region to plasma membrane
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8865637

OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane
type: Axiom
annotated source: GO_0005548
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8867876

GO_0008017
has db xref: Reactome:R-HSA-9614343

Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs
type: Axiom
annotated source: GO_0008017
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9614343

GO_0008028
has db xref: Reactome:R-HSA-429749
has db xref: Reactome:R-HSA-433698
has db xref: Reactome:R-HSA-5624211
has db xref: Reactome:R-HSA-9645220

SLC5A8 transports monocarboxylates from extracellular region to cytosol
type: Axiom
annotated source: GO_0008028
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429749

SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008028
annotated property: hasDbXref
annotated target: Reactome:R-HSA-433698

Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008028
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5624211

SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008028
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645220

GO_0008080
has db xref: Reactome:R-HSA-2468039
has db xref: Reactome:R-HSA-2473152
has db xref: Reactome:R-HSA-6790987
has db xref: Reactome:R-HSA-9636560

Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
type: Axiom
annotated source: GO_0008080
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2468039

Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
type: Axiom
annotated source: GO_0008080
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2473152

NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842
type: Axiom
annotated source: GO_0008080
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6790987

Eis acetylates DUSP16
type: Axiom
annotated source: GO_0008080
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9636560

GO_0008081
has db xref: Reactome:R-HSA-5693578

TDP1 and TDP2 process unligatable DSB ends
type: Axiom
annotated source: GO_0008081
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5693578

GO_0008107
has db xref: Reactome:R-HSA-9036987
has db xref: Reactome:R-HSA-9603982
has db xref: Reactome:R-HSA-9603983

FUT2 transfers Fuc to Type 1 chains to form H antigen-sec
type: Axiom
annotated source: GO_0008107
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9036987

FUT2 transfers Fuc to LeA to form LeB
type: Axiom
annotated source: GO_0008107
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603982

FUT2 transfers Fuc to LeX to form LeY
type: Axiom
annotated source: GO_0008107
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603983

GO_0008108
has db xref: Reactome:R-HSA-5610038
has db xref: Reactome:R-HSA-70361

Defective GALT does not transfer UMP to Gal1P
type: Axiom
annotated source: GO_0008108
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5610038

GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal
type: Axiom
annotated source: GO_0008108
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70361

GO_0008111
has db xref: Reactome:R-HSA-192056
has db xref: Reactome:R-HSA-193452
has db xref: Reactome:R-HSA-193736
has db xref: Reactome:R-HSA-193763
has db xref: Reactome:R-HSA-389897

Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA
type: Axiom
annotated source: GO_0008111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192056

Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA
type: Axiom
annotated source: GO_0008111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193452

Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: Axiom
annotated source: GO_0008111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193736

Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: Axiom
annotated source: GO_0008111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193763

Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
type: Axiom
annotated source: GO_0008111
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389897

GO_0008112
has db xref: Reactome:R-HSA-5359451

NNMT transfers CH3 from SAM to NAM to form MNA
type: Axiom
annotated source: GO_0008112
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5359451

GO_0008113
has db xref: Reactome:R-HSA-1222363
has db xref: Reactome:R-HSA-5676940

MsrA/B reduces peptide-methionine S/R-sulfoxides
type: Axiom
annotated source: GO_0008113
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1222363

MSRA reduces L-methyl-(S)-S-oxide to L-Methionine
type: Axiom
annotated source: GO_0008113
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5676940

GO_0008116
has db xref: Reactome:R-HSA-76496

PTGIS, CYP8A1 isomerise PGH2 to PGI2
type: Axiom
annotated source: GO_0008116
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76496

GO_0008117
has db xref: Reactome:R-HSA-428681

PXLP-SGPL1 cleaves sphingoid-1-phosphates
type: Axiom
annotated source: GO_0008117
annotated property: hasDbXref
annotated target: Reactome:R-HSA-428681

GO_0008119
has db xref: Reactome:R-HSA-158609
has db xref: Reactome:R-HSA-5603379
has db xref: Reactome:R-HSA-9748979
has db xref: Reactome:R-HSA-9748983

TPMT transfers CH3 from AdoMet to 6MP
type: Axiom
annotated source: GO_0008119
annotated property: hasDbXref
annotated target: Reactome:R-HSA-158609

TPMT does not transfer CH3 from AdoMet to 6MP
type: Axiom
annotated source: GO_0008119
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603379

TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
type: Axiom
annotated source: GO_0008119
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748979

TPMT transfers methyl group to 6MP, forming 6MeMP
type: Axiom
annotated source: GO_0008119
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9748983

GO_0008120
has db xref: Reactome:R-HSA-1638104

UGCG transfers glucose to ceramide
type: Axiom
annotated source: GO_0008120
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638104

GO_0008121
has db xref: Reactome:R-HSA-164651

Electron transfer from ubiquinol to cytochrome c of complex III
type: Axiom
annotated source: GO_0008121
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164651

GO_0008123
has db xref: Reactome:R-HSA-192051

CYP7A1 7-hydroxylates CHOL
type: Axiom
annotated source: GO_0008123
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192051

GO_0008124
has db xref: Reactome:R-HSA-71146

4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
type: Axiom
annotated source: GO_0008124
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71146

GO_0008127
has db xref: Reactome:R-HSA-8953398

PIR oxygenates quercetin
type: Axiom
annotated source: GO_0008127
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8953398

GO_0008131
has db xref: Reactome:R-HSA-141186
has db xref: Reactome:R-HSA-141200
has db xref: Reactome:R-HSA-141202
has db xref: Reactome:R-HSA-374909
has db xref: Reactome:R-HSA-379382
has db xref: Reactome:R-HSA-379395
has db xref: Reactome:R-HSA-5603108
has db xref: Reactome:R-HSA-5696146
has db xref: Reactome:R-HSA-5696183

MAOA:FAD oxidatively deaminates of 5HT
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-141186

MAOB:FAD oxidatively deaminates of PEA
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-141200

MAOB:FAD oxidatively deaminates TYR
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-141202

Catabolism of Noradrenaline
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-374909

MAOA:FAD deaminates DA to DOPAC
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379382

MAOA:FAD deaminates 3MT to HVA
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379395

Defective MAOA does not oxidatively deaminate 5HT
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5603108

AOC2 deaminates TYR
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696146

AOC3 deaminates BZAM
type: Axiom
annotated source: GO_0008131
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5696183

GO_0008137
has db xref: Reactome:R-HSA-163217

Complex I oxidises NADH to NAD+, reduces CoQ to QH2
type: Axiom
annotated source: GO_0008137
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163217

GO_0008138
has db xref: Reactome:R-HSA-5675373
has db xref: Reactome:R-HSA-5675376
has db xref: Reactome:R-HSA-9652816

Nuclear DUSPs dephosphorylate MAPKs
type: Axiom
annotated source: GO_0008138
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675373

Cytosolic DUSPs dephosphorylate MAPKs
type: Axiom
annotated source: GO_0008138
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5675376

Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs
type: Axiom
annotated source: GO_0008138
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9652816

GO_0008146
has db xref: Reactome:R-HSA-176588
has db xref: Reactome:R-HSA-176604
has db xref: Reactome:R-HSA-176669
has db xref: Reactome:R-HSA-2022061
has db xref: Reactome:R-HSA-9753277

lithocholate + PAPS => lithocholate sulfate + PAP
type: Axiom
annotated source: GO_0008146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176588

taurolithocholate + PAPS => taurolithocholate sulfate + PAP
type: Axiom
annotated source: GO_0008146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176604

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
type: Axiom
annotated source: GO_0008146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176669

Dermatan sulfate can be further sulfated on position 2 of iduronate
type: Axiom
annotated source: GO_0008146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022061

SULT dimers sulfate APAP to APAP-SO3
type: Axiom
annotated source: GO_0008146
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9753277

GO_0008168
has db xref: Reactome:R-HSA-212269
has db xref: Reactome:R-HSA-379387
has db xref: Reactome:R-HSA-379464
has db xref: Reactome:R-HSA-6800149
has db xref: Reactome:R-HSA-71286
has db xref: Reactome:R-HSA-9710490

DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212269

COMT transfers Met to DA to form 3MT
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379387

COMT transfers Met to DOPAC to form HVA
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379464

N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6800149

guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71286

The GSDME gene promoter is hypermethylated
type: Axiom
annotated source: GO_0008168
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9710490

GO_0008171
has db xref: Reactome:R-HSA-5578717
has db xref: Reactome:R-HSA-5629203
has db xref: Reactome:R-HSA-5629218
has db xref: Reactome:R-HSA-5629237
has db xref: Reactome:R-HSA-6790907

BCDIN3D dimethylates 5' phosphate of pre-miR-145
type: Axiom
annotated source: GO_0008171
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5578717

HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH
type: Axiom
annotated source: GO_0008171
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5629203

HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1
type: Axiom
annotated source: GO_0008171
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5629218

HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH
type: Axiom
annotated source: GO_0008171
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5629237

Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides
type: Axiom
annotated source: GO_0008171
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6790907

GO_0008172
has db xref: Reactome:R-HSA-209821

Methylation of N-acetyl-5-HT to form melatonin
type: Axiom
annotated source: GO_0008172
annotated property: hasDbXref
annotated target: Reactome:R-HSA-209821

GO_0008173
has db xref: Reactome:R-HSA-191784

snRNA Cap hypermethylation
type: Axiom
annotated source: GO_0008173
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191784

GO_0008175
has db xref: Reactome:R-HSA-6782879
has db xref: Reactome:R-HSA-6782881
has db xref: Reactome:R-HSA-6782890
has db xref: Reactome:R-HSA-6783473
has db xref: Reactome:R-HSA-6786500
has db xref: Reactome:R-HSA-6786567

TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782879

LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782881

LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782890

LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6783473

ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786500

KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine
type: Axiom
annotated source: GO_0008175
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6786567

GO_0008176
has db xref: Reactome:R-HSA-6782286

METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46
type: Axiom
annotated source: GO_0008176
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782286

GO_0008177
has db xref: Reactome:R-HSA-163213
has db xref: Reactome:R-HSA-70994

Transfer of electrons through the succinate dehydrogenase complex
type: Axiom
annotated source: GO_0008177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163213

Succinate <=> Fumarate (with FAD redox reaction on enzyme)
type: Axiom
annotated source: GO_0008177
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70994

GO_0008179
has db xref: Reactome:R-HSA-170672

Galpha-olf:GTP binds to adenylate cyclase and activates it
type: Axiom
annotated source: GO_0008179
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170672

GO_0008184
has db xref: Reactome:R-HSA-453339
has db xref: Reactome:R-HSA-453358
has db xref: Reactome:R-HSA-71515
has db xref: Reactome:R-HSA-71590

poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: Axiom
annotated source: GO_0008184
annotated property: hasDbXref
annotated target: Reactome:R-HSA-453339

poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: Axiom
annotated source: GO_0008184
annotated property: hasDbXref
annotated target: Reactome:R-HSA-453358

glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
type: Axiom
annotated source: GO_0008184
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71515

glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
type: Axiom
annotated source: GO_0008184
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71590

GO_0008186
has db xref: Reactome:R-HSA-9770847
has db xref: Reactome:R-HSA-9772351

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
type: Axiom
annotated source: GO_0008186
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9770847

Disassembly of the Intron Lariat Spliceosome (new)
type: Axiom
annotated source: GO_0008186
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9772351

GO_0008194
has db xref: Reactome:R-HSA-162730

phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP
type: Axiom
annotated source: GO_0008194
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162730

GO_0008195
has db xref: Reactome:R-HSA-1483203
has db xref: Reactome:R-HSA-163688
has db xref: Reactome:R-HSA-164056
has db xref: Reactome:R-HSA-2029468
has db xref: Reactome:R-HSA-390329
has db xref: Reactome:R-HSA-5221130
has db xref: Reactome:R-HSA-6797630
has db xref: Reactome:R-HSA-75899

PA is dephosphorylated to DAG by LPIN
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1483203

Dephosphorylation of pChREBP (Thr 666) by PP2A
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163688

Dephosphorylation of pChREBP (Ser 556) by PP2A
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-164056

Conversion of PA into DAG by PAP-1
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2029468

Dephosphorylation of AKT by PP2A
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390329

LPIN catalyzes conversion of phosphatidic acid to diacylglycerol
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5221130

LRPP4(LRPP1-3,5) hydrolyse LPA
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6797630

1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
type: Axiom
annotated source: GO_0008195
annotated property: hasDbXref
annotated target: Reactome:R-HSA-75899

GO_0008233
has db xref: Reactome:R-HSA-205112
has db xref: Reactome:R-HSA-3000243
has db xref: Reactome:R-HSA-3000263
has db xref: Reactome:R-HSA-3065958
has db xref: Reactome:R-HSA-3065959
has db xref: Reactome:R-HSA-3139027
has db xref: Reactome:R-HSA-376149
has db xref: Reactome:R-HSA-4167501
has db xref: Reactome:R-HSA-448678
has db xref: Reactome:R-HSA-5655483
has db xref: Reactome:R-HSA-5684864
has db xref: Reactome:R-HSA-5685902
has db xref: Reactome:R-HSA-6803060

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-205112

Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3000243

TCN2:RCbl is degraded to release RCbl
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3000263

An unknown protease degrades ACACA
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3065958

An unknown protease degrades hCBXs
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3065959

Maturation of HIV Virion
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3139027

Proteolytic processing of SLIT
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-376149

An unknown protease degrades ACACB
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4167501

CTSG cleaves CASP1(1-404)
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-448678

USP1 autocleavage
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5655483

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684864

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5685902

DCD(63-110) is processed to DCD(63-109)
type: Axiom
annotated source: GO_0008233
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6803060

GO_0008234
has db xref: Reactome:R-HSA-2022381
has db xref: Reactome:R-HSA-2467775
has db xref: Reactome:R-HSA-2467809
has db xref: Reactome:R-HSA-5660752
has db xref: Reactome:R-HSA-9757951

Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
type: Axiom
annotated source: GO_0008234
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022381

Autocleavage of ESPL1 (Separase)
type: Axiom
annotated source: GO_0008234
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2467775

ESPL1 (Separase) cleaves centromeric cohesin
type: Axiom
annotated source: GO_0008234
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2467809

USP9X deubiquitinates Ub-SNCA
type: Axiom
annotated source: GO_0008234
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660752

CASP8 cleaves N4BP1 at D424, D490
type: Axiom
annotated source: GO_0008234
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9757951

GO_0008236
has db xref: Reactome:R-HSA-1461993
has db xref: Reactome:R-HSA-2022383
has db xref: Reactome:R-HSA-3132753
has db xref: Reactome:R-HSA-6801766
has db xref: Reactome:R-HSA-9839072
has db xref: Reactome:R-HSA-9839110

pro-HD5 is cleaved by trypsin
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1461993

Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022383

Pancreatic proteases degrade TCN1:RCbl
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3132753

Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6801766

HTRA2 degrades APP (Amyloid-beta precursor protein)
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839072

HTRA2 degrades NDUFA13 (GRIM-19)
type: Axiom
annotated source: GO_0008236
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9839110

GO_0008237
has db xref: Reactome:R-HSA-157629
has db xref: Reactome:R-HSA-157632
has db xref: Reactome:R-HSA-193679
has db xref: Reactome:R-HSA-2022368
has db xref: Reactome:R-HSA-2022393
has db xref: Reactome:R-HSA-2022396
has db xref: Reactome:R-HSA-2022399
has db xref: Reactome:R-HSA-2220944
has db xref: Reactome:R-HSA-2220976
has db xref: Reactome:R-HSA-2666278
has db xref: Reactome:R-HSA-2730752
has db xref: Reactome:R-HSA-3928660
has db xref: Reactome:R-HSA-5211340
has db xref: Reactome:R-HSA-5211356
has db xref: Reactome:R-HSA-5211387
has db xref: Reactome:R-HSA-5211391
has db xref: Reactome:R-HSA-5211400
has db xref: Reactome:R-HSA-5211405
has db xref: Reactome:R-HSA-8986181
has db xref: Reactome:R-HSA-9013284
has db xref: Reactome:R-HSA-9604264
has db xref: Reactome:R-HSA-9662837
has db xref: Reactome:R-HSA-9759522

NOTCH2-ligand complex is cleaved to produce NEXT2
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-157629

Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-157632

alpha-secretase cleaves the p75NTR extracellular domain
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193679

MME:Zn2+ hydrolyses AGT(34-42)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022368

ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022393

MME:Zn2+ hydrolyses AGT(34-43)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022396

ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022399

ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2220944

NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2220976

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2666278

NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2730752

ADAM10 cleaves EFNAs
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3928660

Anthrax lef cleaves target cell MAP2K1 (MEK1)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211340

Anthrax lef cleaves target cell MAP2K2 (MEK2)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211356

Anthrax lef cleaves target cell MAP2K7 (MEK7)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211387

Anthrax lef cleaves target cell MAP2K4 (MEK4)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211391

Anthrax lef cleaves target cell MAP2K3 (MEK3)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211400

Anthrax lef cleaves target cell MAP2K6 (MEK6)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5211405

PITRM1 proteolyzes mitochondrial targeting peptides (presequences)
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8986181

NOTCH3-ligand complex is cleaved to produce NEXT3
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9013284

ADAM10 cleaves NOTCH4
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9604264

p-S,T-ADAM17(215-827):Zn2+ cleaves CD163
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9662837

Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform
type: Axiom
annotated source: GO_0008237
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9759522

GO_0008251
has db xref: Reactome:R-HSA-6782311
has db xref: Reactome:R-HSA-6782336

ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs
type: Axiom
annotated source: GO_0008251
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782311

ADAT1 deaminates adenosine-37 in tRNA(Ala)
type: Axiom
annotated source: GO_0008251
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782336

GO_0008253
has db xref: Reactome:R-HSA-109278
has db xref: Reactome:R-HSA-109291
has db xref: Reactome:R-HSA-109380
has db xref: Reactome:R-HSA-109387
has db xref: Reactome:R-HSA-109415
has db xref: Reactome:R-HSA-109449
has db xref: Reactome:R-HSA-109470
has db xref: Reactome:R-HSA-109480
has db xref: Reactome:R-HSA-109514
has db xref: Reactome:R-HSA-5694126
has db xref: Reactome:R-HSA-74248
has db xref: Reactome:R-HSA-8940070
has db xref: Reactome:R-HSA-8940074
has db xref: Reactome:R-HSA-9755078

NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109278

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109291

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109380

(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109387

AMP + H2O => adenosine + orthophosphate [NT5C1B]
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109415

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109449

(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109470

TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109480

TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-109514

NT5C3B hydrolyses 7MGP to 7MG
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694126

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74248

NT5E:Zn2+ hydrolyses NAD+
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940070

NT5E:Zn2+ hydrolyses NMN
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8940074

NT5C2 tetramer dephosphorylates RBV-MP
type: Axiom
annotated source: GO_0008253
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9755078

GO_0008260
has db xref: Reactome:R-HSA-74177

OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA
type: Axiom
annotated source: GO_0008260
annotated property: hasDbXref
annotated target: Reactome:R-HSA-74177

GO_0008265
has db xref: Reactome:R-HSA-947499

Exchange of oxygen with sulfur in MoCo
type: Axiom
annotated source: GO_0008265
annotated property: hasDbXref
annotated target: Reactome:R-HSA-947499

GO_0008273
has db xref: Reactome:R-HSA-2514891
has db xref: Reactome:R-HSA-425678
has db xref: Reactome:R-HSA-5625841
has db xref: Reactome:R-HSA-5626270
has db xref: Reactome:R-HSA-5626316
has db xref: Reactome:R-HSA-5626356

SLC24A1 exchanges 4Na+ for Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2514891

SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425678

Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5625841

Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5626270

SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5626316

Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+
type: Axiom
annotated source: GO_0008273
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5626356

GO_0008276
has db xref: Reactome:R-HSA-9632182

PRMT1 methylates ESRs
type: Axiom
annotated source: GO_0008276
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9632182

GO_0008294
has db xref: Reactome:R-HSA-111930
has db xref: Reactome:R-HSA-442715

Adenylate cyclase produces cAMP
type: Axiom
annotated source: GO_0008294
annotated property: hasDbXref
annotated target: Reactome:R-HSA-111930

Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP
type: Axiom
annotated source: GO_0008294
annotated property: hasDbXref
annotated target: Reactome:R-HSA-442715

GO_0008296
has db xref: Reactome:R-HSA-9023943

MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end
type: Axiom
annotated source: GO_0008296
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9023943

GO_0008308
has db xref: Reactome:R-HSA-9012374

VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
type: Axiom
annotated source: GO_0008308
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9012374

GO_0008320
has db xref: Reactome:R-HSA-1268022
has db xref: Reactome:R-HSA-1299475
has db xref: Reactome:R-HSA-184269
has db xref: Reactome:R-HSA-3149434
has db xref: Reactome:R-HSA-5205661
has db xref: Reactome:R-HSA-5210943
has db xref: Reactome:R-HSA-5210947
has db xref: Reactome:R-HSA-5228406
has db xref: Reactome:R-HSA-5229111
has db xref: Reactome:R-HSA-5244404
has db xref: Reactome:R-HSA-5244428
has db xref: Reactome:R-HSA-5244506
has db xref: Reactome:R-HSA-5246514
has db xref: Reactome:R-HSA-5250616
has db xref: Reactome:R-HSA-5250884
has db xref: Reactome:R-HSA-5250972
has db xref: Reactome:R-HSA-5336420
has db xref: Reactome:R-HSA-9636375
has db xref: Reactome:R-HSA-9698930
has db xref: Reactome:R-HSA-9698933

TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1268022

TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1299475

Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-184269

Transport of GAG to the Plasma Membrane
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3149434

Pink1 is recruited from the cytoplasm to the mitochondria
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5205661

pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5210943

pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5210947

tetX HC transports tetX LC from target cell endosome membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5228406

AP4 transports APP from trans-Golgi network to endosome lumen
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5229111

botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5244404

botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5244428

botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5244506

botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5246514

botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250616

botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250884

botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5250972

DT fragment B transports DT fragment A from target cell endosome membrane
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5336420

SecA2 transports SapM from cytoplasm to cytosol
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9636375

HCMV C Nucleocapsid Translocation
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698930

HCMV B Nucleocapsid Translocation
type: Axiom
annotated source: GO_0008320
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9698933

GO_0008336
has db xref: Reactome:R-HSA-71261

BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA
type: Axiom
annotated source: GO_0008336
annotated property: hasDbXref
annotated target: Reactome:R-HSA-71261

GO_0008349
has db xref: Reactome:R-HSA-177692
has db xref: Reactome:R-HSA-936991
has db xref: Reactome:R-HSA-9645442

Activation of recruited TAK1 within the activated TLR3 complex
type: Axiom
annotated source: GO_0008349
annotated property: hasDbXref
annotated target: Reactome:R-HSA-177692

Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
type: Axiom
annotated source: GO_0008349
annotated property: hasDbXref
annotated target: Reactome:R-HSA-936991

Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
type: Axiom
annotated source: GO_0008349
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9645442

GO_0008353
has db xref: Reactome:R-HSA-167191
has db xref: Reactome:R-HSA-170704
has db xref: Reactome:R-HSA-170706

Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
type: Axiom
annotated source: GO_0008353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167191

Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
type: Axiom
annotated source: GO_0008353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170704

Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
type: Axiom
annotated source: GO_0008353
annotated property: hasDbXref
annotated target: Reactome:R-HSA-170706

GO_0008373
has db xref: Reactome:R-HSA-9683769
has db xref: Reactome:R-HSA-9694718
has db xref: Reactome:R-HSA-9697018
has db xref: Reactome:R-HSA-981814

O-glycosylation of 3a is terminated
type: Axiom
annotated source: GO_0008373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9683769

O-glycosylation of 3a is terminated
type: Axiom
annotated source: GO_0008373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694718

Addition of sialic acids on some Spike glycosyl sidechains
type: Axiom
annotated source: GO_0008373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9697018

ST6GALNAC2 transfers sialic acid to Core 1 mucins
type: Axiom
annotated source: GO_0008373
annotated property: hasDbXref
annotated target: Reactome:R-HSA-981814

GO_0008374
has db xref: Reactome:R-HSA-1482775
has db xref: Reactome:R-HSA-1482781
has db xref: Reactome:R-HSA-1482850
has db xref: Reactome:R-HSA-1482861
has db xref: Reactome:R-HSA-1482867
has db xref: Reactome:R-HSA-162683
has db xref: Reactome:R-HSA-3238694
has db xref: Reactome:R-HSA-422017
has db xref: Reactome:R-HSA-422104
has db xref: Reactome:R-HSA-5358343
has db xref: Reactome:R-HSA-5483229

MLCL is acylated to CL by HADH (IM)
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482775

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482781

MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482850

MLCL is acylated to CL by LCLAT1 (ER)
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482861

DLCL is acylated to MLCL by LCLAT1 (ER)
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482867

glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-162683

PORCN palmitoleoylates N-glycosyl WNTs
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3238694

Ghrelin O-acyltransferase decanoylates Proghrelin
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-422017

Ghrelin O-acyltransferase octanoylates Proghrelin
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-422104

HHAT palmitoylates Hh N-terminal fragment
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358343

HHAT G287V doesn't palmitoylate Hh-Np
type: Axiom
annotated source: GO_0008374
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5483229

GO_0008375
has db xref: Reactome:R-HSA-5694487
has db xref: Reactome:R-HSA-8879117
has db xref: Reactome:R-HSA-9683648
has db xref: Reactome:R-HSA-9694656

A4GNT transfers GlcNAc to core 2 mucins
type: Axiom
annotated source: GO_0008375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5694487

POMGNT2 transfers GlcNAc to Man-DAG1
type: Axiom
annotated source: GO_0008375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8879117

Spike trimer glycoside chains are extended
type: Axiom
annotated source: GO_0008375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9683648

Spike trimer glycoside chains are extended
type: Axiom
annotated source: GO_0008375
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694656

GO_0008376
has db xref: Reactome:R-HSA-8855954
has db xref: Reactome:R-HSA-8931648
has db xref: Reactome:R-HSA-9605700

B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD
type: Axiom
annotated source: GO_0008376
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8855954

B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1
type: Axiom
annotated source: GO_0008376
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8931648

B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda
type: Axiom
annotated source: GO_0008376
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9605700

GO_0008378
has db xref: Reactome:R-HSA-1964501

Addition of galactose to Core 6 glycoprotein
type: Axiom
annotated source: GO_0008378
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1964501

GO_0008379
has db xref: Reactome:R-HSA-2161612
has db xref: Reactome:R-HSA-3322995
has db xref: Reactome:R-HSA-3341343
has db xref: Reactome:R-HSA-3697882
has db xref: Reactome:R-HSA-3697894

PGH2 is reduced to PGF2a by FAM213B
type: Axiom
annotated source: GO_0008379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2161612

PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
type: Axiom
annotated source: GO_0008379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322995

PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
type: Axiom
annotated source: GO_0008379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3341343

PRDX5 reduces peroxynitrite to nitrite using TXN
type: Axiom
annotated source: GO_0008379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3697882

PRDX5 reduces peroxynitrite to nitrite using TXN2
type: Axiom
annotated source: GO_0008379
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3697894

GO_0008384
has db xref: Reactome:R-HSA-5684267
has db xref: Reactome:R-HSA-5684275

IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
type: Axiom
annotated source: GO_0008384
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684267

IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
type: Axiom
annotated source: GO_0008384
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5684275

GO_0008386
has db xref: Reactome:R-HSA-193054
has db xref: Reactome:R-HSA-193065
has db xref: Reactome:R-HSA-193101

Oxidation of cholesterol to 22beta-hydroxycholesterol
type: Axiom
annotated source: GO_0008386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193054

Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol
type: Axiom
annotated source: GO_0008386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193065

CYP11A1 cleaves 20a,22b-DHCHOL
type: Axiom
annotated source: GO_0008386
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193101

GO_0008389
has db xref: Reactome:R-HSA-211881
has db xref: Reactome:R-HSA-76453

Coumarin is 7-hydroxylated by CYP2A13
type: Axiom
annotated source: GO_0008389
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211881

Coumarin is 7-hydroxylated by CYP2A6
type: Axiom
annotated source: GO_0008389
annotated property: hasDbXref
annotated target: Reactome:R-HSA-76453

GO_0008392
has db xref: Reactome:R-HSA-211983

CYP2J2 oxidises ARA
type: Axiom
annotated source: GO_0008392
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211983

GO_0008395
has db xref: Reactome:R-HSA-191983
has db xref: Reactome:R-HSA-191999
has db xref: Reactome:R-HSA-192042
has db xref: Reactome:R-HSA-192054
has db xref: Reactome:R-HSA-192123
has db xref: Reactome:R-HSA-193060
has db xref: Reactome:R-HSA-193143
has db xref: Reactome:R-HSA-193393
has db xref: Reactome:R-HSA-193460
has db xref: Reactome:R-HSA-193497
has db xref: Reactome:R-HSA-193713
has db xref: Reactome:R-HSA-193719
has db xref: Reactome:R-HSA-193737
has db xref: Reactome:R-HSA-193780
has db xref: Reactome:R-HSA-193787
has db xref: Reactome:R-HSA-193792
has db xref: Reactome:R-HSA-193965
has db xref: Reactome:R-HSA-193995
has db xref: Reactome:R-HSA-5601849
has db xref: Reactome:R-HSA-5602170
has db xref: Reactome:R-HSA-6785244
has db xref: Reactome:R-HSA-6785245
has db xref: Reactome:R-HSA-9035960
has db xref: Reactome:R-HSA-9758674

Cholesterol is hydroxylated to 25-hydroxycholesterol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191983

CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191999

5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192042

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192054

CYP27A1 27-hydroxylates CHOL
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192123

CYP19A1 hydroxylates ANDST to E1
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193060

CYP19A1 hydroxylates TEST to EST17b
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193143

5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193393

3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193460

5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193497

3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193713

5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193719

3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193737

5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193780

5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193787

CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193792

CYP11B2 oxidises 18HCORST to ALDO
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193965

CYP11B2 18-hydroxylates CORST to 18HCORST
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-193995

Defective CYP19A1 does not convert ANDST to E1
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5601849

CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602170

Defective CYP11B2 does not oxidise 18HCORST
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6785244

Defective CYP11B2 does not oxidise CORST
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6785245

Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9035960

CYP3A4 oxidizes PREDN,PREDL
type: Axiom
annotated source: GO_0008395
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9758674

GO_0008396
has db xref: Reactome:R-HSA-191972
has db xref: Reactome:R-HSA-192065
has db xref: Reactome:R-HSA-192178
has db xref: Reactome:R-HSA-5602885

27-hydroxycholesterol is 7alpha-hydroxylated
type: Axiom
annotated source: GO_0008396
annotated property: hasDbXref
annotated target: Reactome:R-HSA-191972

CYP7B1 7-hydroxylates 25OH-CHOL
type: Axiom
annotated source: GO_0008396
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192065

CYP39A1 7-hydroxylates 24OH-CHOL
type: Axiom
annotated source: GO_0008396
annotated property: hasDbXref
annotated target: Reactome:R-HSA-192178

Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL
type: Axiom
annotated source: GO_0008396
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602885

GO_0008398
has db xref: Reactome:R-HSA-194678

CYP51A1 demethylates LNSOL
type: Axiom
annotated source: GO_0008398
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194678

GO_0008401
has db xref: Reactome:R-HSA-211874
has db xref: Reactome:R-HSA-211923
has db xref: Reactome:R-HSA-212007
has db xref: Reactome:R-HSA-5362525
has db xref: Reactome:R-HSA-5602050
has db xref: Reactome:R-HSA-5602063

CYP2S1 4-hydroxylates atRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211874

CYP26C1 4-hydroxylates 9cRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-211923

CYP26A1,B1 4-hydroxylate atRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-212007

CYP26A1,B1,C1 4-hydroxylate atRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5362525

Defective CYP26C1 does not 4-hydroxylate 9cRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602050

Defective CYP26B1 does not 4-hydroxylate atRA
type: Axiom
annotated source: GO_0008401
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5602063

GO_0008408
has db xref: Reactome:R-HSA-3245943

Viral DNA cleavage by TREX1
type: Axiom
annotated source: GO_0008408
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3245943

GO_0008409
has db xref: Reactome:R-HSA-5358599
has db xref: Reactome:R-HSA-5358619

EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
type: Axiom
annotated source: GO_0008409
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358599

EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)
type: Axiom
annotated source: GO_0008409
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5358619

GO_0008410
has db xref: Reactome:R-HSA-70713

BCKDH transfers CoA group from CoA-SH to BCAAs
type: Axiom
annotated source: GO_0008410
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70713

GO_0008417
has db xref: Reactome:R-HSA-9033949
has db xref: Reactome:R-HSA-9846332

FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC
type: Axiom
annotated source: GO_0008417
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9033949

FUT1,2 transfer fucose to gangliosides
type: Axiom
annotated source: GO_0008417
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9846332

GO_0008424
has db xref: Reactome:R-HSA-1028788
has db xref: Reactome:R-HSA-9696980

FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP
type: Axiom
annotated source: GO_0008424
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1028788

Spike trimer glycoside chains get additional branches
type: Axiom
annotated source: GO_0008424
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9696980

GO_0008440
has db xref: Reactome:R-HSA-1855153
has db xref: Reactome:R-HSA-1855233

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
type: Axiom
annotated source: GO_0008440
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855153

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
type: Axiom
annotated source: GO_0008440
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1855233

GO_0008441
has db xref: Reactome:R-HSA-176606
has db xref: Reactome:R-HSA-8953499

Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
type: Axiom
annotated source: GO_0008441
annotated property: hasDbXref
annotated target: Reactome:R-HSA-176606

IMPAD1 hydrolyses PAP to AMP
type: Axiom
annotated source: GO_0008441
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8953499

GO_0008442
has db xref: Reactome:R-HSA-508473
has db xref: Reactome:R-HSA-70885

methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+
type: Axiom
annotated source: GO_0008442
annotated property: hasDbXref
annotated target: Reactome:R-HSA-508473

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
type: Axiom
annotated source: GO_0008442
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70885

GO_0008444
has db xref: Reactome:R-HSA-1482939

CDP-DAG is converted to PGP by PGS1
type: Axiom
annotated source: GO_0008444
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1482939

GO_0008445
has db xref: Reactome:R-HSA-6810076

DDO oxidizes D-Asp to OA
type: Axiom
annotated source: GO_0008445
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6810076

GO_0008446
has db xref: Reactome:R-HSA-6787632

GMDS dehydrates GDP-Man to GDP-DHDMan
type: Axiom
annotated source: GO_0008446
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6787632

GO_0008448
has db xref: Reactome:R-HSA-6803789

AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA
type: Axiom
annotated source: GO_0008448
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6803789

GO_0008449
has db xref: Reactome:R-HSA-1638032
has db xref: Reactome:R-HSA-2263495

N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
type: Axiom
annotated source: GO_0008449
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1638032

Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S
type: Axiom
annotated source: GO_0008449
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2263495

GO_0008453
has db xref: Reactome:R-HSA-389684
has db xref: Reactome:R-HSA-904864

glyoxylate + alanine => glycine + pyruvate [peroxisome]
type: Axiom
annotated source: GO_0008453
annotated property: hasDbXref
annotated target: Reactome:R-HSA-389684

Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate
type: Axiom
annotated source: GO_0008453
annotated property: hasDbXref
annotated target: Reactome:R-HSA-904864

GO_0008454
has db xref: Reactome:R-HSA-9696980
has db xref: Reactome:R-HSA-975903

Spike trimer glycoside chains get additional branches
type: Axiom
annotated source: GO_0008454
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9696980

Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV
type: Axiom
annotated source: GO_0008454
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975903

GO_0008455
has db xref: Reactome:R-HSA-4793955
has db xref: Reactome:R-HSA-9694656
has db xref: Reactome:R-HSA-975829

Defective MGAT2 does not transfer GlcNAc to N-glycans
type: Axiom
annotated source: GO_0008455
annotated property: hasDbXref
annotated target: Reactome:R-HSA-4793955

Spike trimer glycoside chains are extended
type: Axiom
annotated source: GO_0008455
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9694656

Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
type: Axiom
annotated source: GO_0008455
annotated property: hasDbXref
annotated target: Reactome:R-HSA-975829

GO_0008458
has db xref: Reactome:R-HSA-390281

4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
type: Axiom
annotated source: GO_0008458
annotated property: hasDbXref
annotated target: Reactome:R-HSA-390281

GO_0008459
has db xref: Reactome:R-HSA-2018682
has db xref: Reactome:R-HSA-3595175

CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains
type: Axiom
annotated source: GO_0008459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2018682

Defective CHST3 does not transfer SO4(2-) to chondroitin
type: Axiom
annotated source: GO_0008459
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3595175

GO_0008466
has db xref: Reactome:R-HSA-3322003
has db xref: Reactome:R-HSA-3322014
has db xref: Reactome:R-HSA-3322019
has db xref: Reactome:R-HSA-3322025
has db xref: Reactome:R-HSA-3814838

Autoglucosylation of GYG1 complexed with GYS1-b
type: Axiom
annotated source: GO_0008466
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322003

Autoglucosylation of GYG2 complexed with GYS2-a
type: Axiom
annotated source: GO_0008466
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322014

Autoglucosylation of GYG2 complexed with GYS2-b
type: Axiom
annotated source: GO_0008466
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322019

Autoglucosylation of GYG1 complexed with GYS1-a
type: Axiom
annotated source: GO_0008466
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3322025

Defective GYG1 is not autoglucosyolated
type: Axiom
annotated source: GO_0008466
annotated property: hasDbXref
annotated target: Reactome:R-HSA-3814838

GO_0008467
has db xref: Reactome:R-HSA-2076383
has db xref: Reactome:R-HSA-2076611

HS3ST1 sulfates GlcN at C3 in heparan sulfate
type: Axiom
annotated source: GO_0008467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2076383

HS3STs sulfate GlcN at C3 in heparan sulfate
type: Axiom
annotated source: GO_0008467
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2076611

GO_0008470
has db xref: Reactome:R-HSA-70745

isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
type: Axiom
annotated source: GO_0008470
annotated property: hasDbXref
annotated target: Reactome:R-HSA-70745

GO_0008474
has db xref: Reactome:R-HSA-203613
has db xref: Reactome:R-HSA-5690517
has db xref: Reactome:R-HSA-8933328
has db xref: Reactome:R-HSA-9647994

depalmitoylation of eNOS
type: Axiom
annotated source: GO_0008474
annotated property: hasDbXref
annotated target: Reactome:R-HSA-203613

PPT1 hydrolyses palmitoylated proteins
type: Axiom
annotated source: GO_0008474
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5690517

LYPLA2 hydrolyses PALM-C3,4-GAP43
type: Axiom
annotated source: GO_0008474
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8933328

RAS proteins are depalmitoylated
type: Axiom
annotated source: GO_0008474
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9647994

GO_0008475
has db xref: Reactome:R-HSA-1981104

Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
type: Axiom
annotated source: GO_0008475
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1981104

GO_0008476
has db xref: Reactome:R-HSA-8954262
has db xref: Reactome:R-HSA-9668023
has db xref: Reactome:R-HSA-9668148

TPST1,2 transfer SO4(2-) from PAPS to PODXL2
type: Axiom
annotated source: GO_0008476
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8954262

TPST1,2 transfer SO4(2-) from PAPS to FVIII
type: Axiom
annotated source: GO_0008476
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9668023

F8 variant is not sulfonated at Y1699
type: Axiom
annotated source: GO_0008476
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9668148

GO_0008478
has db xref: Reactome:R-HSA-964958
has db xref: Reactome:R-HSA-964962
has db xref: Reactome:R-HSA-964970

2xPDXK:2xZn2+ phosphorylates PXA
type: Axiom
annotated source: GO_0008478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964958

2xPDKX:2xZn2+ phosphorylates PDX
type: Axiom
annotated source: GO_0008478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964962

2xPDXK:2xZn2+ phosphorylates PXL
type: Axiom
annotated source: GO_0008478
annotated property: hasDbXref
annotated target: Reactome:R-HSA-964970

GO_0008479
has db xref: Reactome:R-HSA-6782443

QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)
type: Axiom
annotated source: GO_0008479
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6782443

GO_0008480
has db xref: Reactome:R-HSA-6797913

SARDH:FAD oxidatively demethylates SARC to Gly
type: Axiom
annotated source: GO_0008480
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6797913

GO_0008482
has db xref: Reactome:R-HSA-1614544

Sulfite is oxidized to sulfate
type: Axiom
annotated source: GO_0008482
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1614544

GO_0008483
has db xref: Reactome:R-HSA-1237102

Transamination of MOB to methionine
type: Axiom
annotated source: GO_0008483
annotated property: hasDbXref
annotated target: Reactome:R-HSA-1237102

GO_0008488
has db xref: Reactome:R-HSA-159752
has db xref: Reactome:R-HSA-159761
has db xref: Reactome:R-HSA-159795
has db xref: Reactome:R-HSA-159803
has db xref: Reactome:R-HSA-159819
has db xref: Reactome:R-HSA-159826
has db xref: Reactome:R-HSA-163810
has db xref: Reactome:R-HSA-163820
has db xref: Reactome:R-HSA-6807214
has db xref: Reactome:R-HSA-9673231

GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159752

GGCX gamma-carboxylates F7(21-466) (pro-factor VII)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159761

GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159795

GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159803

GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159819

GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-159826

GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163810

GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-163820

GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807214

GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)
type: Axiom
annotated source: GO_0008488
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9673231

GO_0008489
has db xref: Reactome:R-HSA-9851347

B4GALT5/6 transfer Gal to GlcCer
type: Axiom
annotated source: GO_0008489
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9851347

GO_0008495
has db xref: Reactome:R-HSA-2995330

COX10 transforms heme to heme O
type: Axiom
annotated source: GO_0008495
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2995330

GO_0008496
has db xref: Reactome:R-HSA-6799581

MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
type: Axiom
annotated source: GO_0008496
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6799581

GO_0008499
has db xref: Reactome:R-HSA-914010
has db xref: Reactome:R-HSA-9603989
has db xref: Reactome:R-HSA-9845516

Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
type: Axiom
annotated source: GO_0008499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-914010

B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain
type: Axiom
annotated source: GO_0008499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9603989

B3GALT4 transfers Gal to gangliosides
type: Axiom
annotated source: GO_0008499
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9845516

GO_0008504
has db xref: Reactome:R-HSA-372542
has db xref: Reactome:R-HSA-379393
has db xref: Reactome:R-HSA-380586
has db xref: Reactome:R-HSA-380620
has db xref: Reactome:R-HSA-444160
has db xref: Reactome:R-HSA-5660706

Loading of dopamine into synaptic veiscles
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-372542

SLC6A3 cotransports DA, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-379393

loading of Serotonin in synaptic vesicles
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380586

Reuptake of serotonin from the synapse
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-380620

VMAT1/2 can mediate the transport of biogenic amines
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444160

Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008504
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5660706

GO_0008507
has db xref: Reactome:R-HSA-429591
has db xref: Reactome:R-HSA-5658195

SLC5A5 cotransports Na+ with I- from extracellular region to cytosol
type: Axiom
annotated source: GO_0008507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429591

Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol
type: Axiom
annotated source: GO_0008507
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5658195

GO_0008508
has db xref: Reactome:R-HSA-194121
has db xref: Reactome:R-HSA-194187
has db xref: Reactome:R-HSA-433089

SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194121

SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-194187

SOAT can transport taurolithocholate-3-sulphate
type: Axiom
annotated source: GO_0008508
annotated property: hasDbXref
annotated target: Reactome:R-HSA-433089

GO_0008509
has db xref: Reactome:R-HSA-166214

FA anion flip-flops to the opposite surface
type: Axiom
annotated source: GO_0008509
annotated property: hasDbXref
annotated target: Reactome:R-HSA-166214

GO_0008510
has db xref: Reactome:R-HSA-425483
has db xref: Reactome:R-HSA-5656219
has db xref: Reactome:R-HSA-8878664

SLC4A5,7,9 cotransport Na+ with 3HCO3-
type: Axiom
annotated source: GO_0008510
annotated property: hasDbXref
annotated target: Reactome:R-HSA-425483

Defective SLC4A4 does not cotransport Na+ with 3HCO3-
type: Axiom
annotated source: GO_0008510
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5656219

SLC4A4 cotransports Na+ with 3HCO3-
type: Axiom
annotated source: GO_0008510
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8878664

GO_0008511
has db xref: Reactome:R-HSA-426086
has db xref: Reactome:R-HSA-5623588

SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol
type: Axiom
annotated source: GO_0008511
annotated property: hasDbXref
annotated target: Reactome:R-HSA-426086

Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol
type: Axiom
annotated source: GO_0008511
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623588

GO_0008513
has db xref: Reactome:R-HSA-549241

SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
type: Axiom
annotated source: GO_0008513
annotated property: hasDbXref
annotated target: Reactome:R-HSA-549241

GO_0008514
has db xref: Reactome:R-HSA-2142859
has db xref: Reactome:R-HSA-561041
has db xref: Reactome:R-HSA-9794830

Growing HA is extruded from the cell by ABCC5
type: Axiom
annotated source: GO_0008514
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2142859

OAT1-3 transport organic anions with antiport of dicarboxylic acids
type: Axiom
annotated source: GO_0008514
annotated property: hasDbXref
annotated target: Reactome:R-HSA-561041

SLC22A8 transports Cipro into renal cell
type: Axiom
annotated source: GO_0008514
annotated property: hasDbXref
annotated target: Reactome:R-HSA-9794830

GO_0008517
has db xref: Reactome:R-HSA-200646
has db xref: Reactome:R-HSA-200652
has db xref: Reactome:R-HSA-200680
has db xref: Reactome:R-HSA-200720
has db xref: Reactome:R-HSA-200729

Cytosolic folate export across the plasma membrane
type: Axiom
annotated source: GO_0008517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200646

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol
type: Axiom
annotated source: GO_0008517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200652

SLC25A32 transports THF from cytosol to mitochondrial matrix
type: Axiom
annotated source: GO_0008517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200680

SLC25A32 transports THF from mitochondrial matrix to cytosol
type: Axiom
annotated source: GO_0008517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200720

SLC46A1 transports FOLA from extracellular region to cytosol
type: Axiom
annotated source: GO_0008517
annotated property: hasDbXref
annotated target: Reactome:R-HSA-200729

GO_0008519
has db xref: Reactome:R-HSA-444393
has db xref: Reactome:R-HSA-444416
has db xref: Reactome:R-HSA-444419
has db xref: Reactome:R-HSA-446277
has db xref: Reactome:R-HSA-446278
has db xref: Reactome:R-HSA-5623051

RhCG mediates ammonium influx into kidney collecting duct cells
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444393

RHAG transports NH4+ from cytosol to extracellular region (red blood cells)
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444416

RhBG mediates ammonium effflux out of kidney collecting duct cells
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-444419

RhCG mediates ammonium efflux out of kidney collecting duct cells
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446277

RhBG mediates ammonium influx into kidney collecting duct cells
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-446278

Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc)
type: Axiom
annotated source: GO_0008519
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5623051

GO_0008521
has db xref: Reactome:R-HSA-5649742
has db xref: Reactome:R-HSA-727759

Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen
type: Axiom
annotated source: GO_0008521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-5649742

SLC33A1 transports Ac-CoA from cytosol to Golgi lumen
type: Axiom
annotated source: GO_0008521
annotated property: hasDbXref
annotated target: Reactome:R-HSA-727759

GO_0008523
has db xref: Reactome:R-HSA-199206
has db xref: Reactome:R-HSA-199219
has db xref: Reactome:R-HSA-429581

SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
type: Axiom
annotated source: GO_0008523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199206

SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
type: Axiom
annotated source: GO_0008523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-199219

SLC5A6 transports vitamins from extracellular region to cytosol
type: Axiom
annotated source: GO_0008523
annotated property: hasDbXref
annotated target: Reactome:R-HSA-429581

GO_0008526
has db xref: Reactome:R-HSA-8869241
has db xref: Reactome:R-HSA-8874470

PITPNM1,2,3 exchange PI for PA
type: Axiom
annotated source: GO_0008526
annotated property: hasDbXref
annotated target: Reactome:R-HSA-8869241