{ "graphs" : [ { "id" : "http://purl.obolibrary.org/obo/go/subsets/gocheck_do_not_manually_annotate.owl", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", "val" : "2024-01-26" } ], "version" : "http://purl.obolibrary.org/obo/go/2024-01-26/subsets/gocheck_do_not_manually_annotate.owl" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000050", "lbl" : "part of", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BFO:0000050" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "part_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "lbl" : "has part", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BFO:0000051" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "has_part" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000062", "lbl" : "preceded by", "meta" : { "xrefs" : [ { "val" : "BFO:0000062" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "preceded_by" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000063", "lbl" : "precedes", "meta" : { "xrefs" : [ { "val" : "BFO:0000063" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "precedes" } ] } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000066", "lbl" : "occurs in", "type" : "PROPERTY", "meta" : { "xrefs" : [ { "val" : "BFO:0000066" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "occurs_in" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0000040", "lbl" : "results in", "meta" : { "comments" : [ "This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change." ], "xrefs" : [ { "val" : "GOREL:0000040" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "cjm" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-03-14T10:35:44Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "results_in" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0001019", "lbl" : "results in division of", "meta" : { "comments" : [ "use occurs_in" ], "xrefs" : [ { "val" : "GOREL:0001019" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "results_in_division_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0002003", "lbl" : "results in distribution of", "meta" : { "xrefs" : [ { "val" : "GOREL:0002003" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "results_in_distribution_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0002004", "lbl" : "results in fission of", "meta" : { "xrefs" : [ { "val" : "GOREL:0002004" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "results_in_fission_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0012006", "lbl" : "results in maintenance of", "meta" : { "xrefs" : [ { "val" : "GOREL:0012006" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "results_in_maintenance_of" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000910", "lbl" : "cytokinesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell cycle cytokinesis" }, { "pred" : "hasExactSynonym", "val" : "cytokinesis involved in cell cycle", "xrefs" : [ "GOC:dph", "GOC:tb" ] } ], "xrefs" : [ { "val" : "Wikipedia:Cytokinesis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0007104" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0016288" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0033205" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001101", "lbl" : "response to acid chemical", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.", "xrefs" : [ "GOC:go_curators", "GOC:rn" ] }, "comments" : [ "This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "response to acid" }, { "pred" : "hasRelatedSynonym", "val" : "response to acid anion" }, { "pred" : "hasRelatedSynonym", "val" : "response to oxoanion" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001539", "lbl" : "cilium or flagellum-dependent cell motility", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.", "xrefs" : [ "GOC:cilia", "GOC:hjd", "GOC:krc" ] }, "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "ciliary/flagellar motility" }, { "pred" : "hasRelatedSynonym", "val" : "ciliary or bacterial-type flagellar motility" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002831", "lbl" : "regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002832", "lbl" : "negative regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "downregulation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of response to biotic stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002833", "lbl" : "positive regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "upregulation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "activation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of response to biotic stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006950", "lbl" : "response to stress", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to abiotic stress" }, { "pred" : "hasRelatedSynonym", "val" : "response to biotic stress" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007049", "lbl" : "cell cycle", "type" : "CLASS", "meta" : { "definition" : { "val" : "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.", "xrefs" : [ "GOC:go_curators", "GOC:mtg_cell_cycle" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell-division cycle" } ], "xrefs" : [ { "val" : "Wikipedia:Cell_cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007610", "lbl" : "behavior", "type" : "CLASS", "meta" : { "definition" : { "val" : "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.", "xrefs" : [ "GOC:ems", "GOC:jl", "ISBN:0395448956", "PMID:20160973" ] }, "comments" : [ "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "behavioral response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "behaviour" }, { "pred" : "hasExactSynonym", "val" : "behavioural response to stimulus" }, { "pred" : "hasRelatedSynonym", "val" : "single-organism behavior" } ], "xrefs" : [ { "val" : "Wikipedia:Behavior" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-09-20T14:06:08Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0023032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044708" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044709" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008152", "lbl" : "metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.", "xrefs" : [ "GOC:go_curators", "ISBN:0198547684" ] }, "comments" : [ "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "metabolism" }, { "pred" : "hasNarrowSynonym", "val" : "metabolic process resulting in cell growth" }, { "pred" : "hasNarrowSynonym", "val" : "metabolism resulting in cell growth" }, { "pred" : "hasNarrowSynonym", "val" : "multicellular organism metabolic process" }, { "pred" : "hasRelatedSynonym", "val" : "single-organism metabolic process" } ], "xrefs" : [ { "val" : "Wikipedia:Metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-17T15:46:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044236" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044710" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009605", "lbl" : "response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.", "xrefs" : [ "GOC:hb" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to environmental stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009607", "lbl" : "response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.", "xrefs" : [ "GOC:hb" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "response to biotic stress" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009628", "lbl" : "response to abiotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.", "xrefs" : [ "GOC:hb" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "response to abiotic stress" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/16572" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009719", "lbl" : "response to endogenous stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", "xrefs" : [ "GOC:sm" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009790", "lbl" : "embryo development", "type" : "CLASS", "meta" : { "definition" : { "val" : "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.", "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "embryogenesis and morphogenesis" }, { "pred" : "hasExactSynonym", "val" : "embryogenesis" }, { "pred" : "hasExactSynonym", "val" : "embryonal development" } ], "xrefs" : [ { "val" : "Wikipedia:Embryogenesis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0009795" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014076", "lbl" : "response to fluoxetine", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.", "xrefs" : [ "GOC:ef", "GOC:pr" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to SSRI" }, { "pred" : "hasRelatedSynonym", "val" : "response to selective serotonin reuptake inhibitor" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031577", "lbl" : "spindle checkpoint signaling", "type" : "CLASS", "meta" : { "definition" : { "val" : "A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "signal transduction involved in spindle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "spindle checkpoint" } ], "xrefs" : [ { "val" : "Wikipedia:Spindle_checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20935" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072416" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032101", "lbl" : "regulation of response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of a response to an external stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032102", "lbl" : "negative regulation of response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of response to external stimulus" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of response to external stimulus" }, { "pred" : "hasExactSynonym", "val" : "downregulation of response to external stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of response to external stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032103", "lbl" : "positive regulation of response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates, maintains or increases the rate of a response to an external stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of response to external stimulus" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of response to external stimulus" }, { "pred" : "hasExactSynonym", "val" : "upregulation of response to external stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "activation of response to external stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of response to external stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033554", "lbl" : "cellular response to stress", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036270", "lbl" : "response to diuretic", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:26:24Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036271", "lbl" : "response to methylphenidate", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.", "xrefs" : [ "GOC:hp", "Wikipedia:Methylphenidate" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to MPD", "xrefs" : [ "CHEBI:6887" ] }, { "pred" : "hasExactSynonym", "val" : "response to MPH", "xrefs" : [ "CHEBI:6887" ] }, { "pred" : "hasExactSynonym", "val" : "response to ritalin", "xrefs" : [ "CHEBI:6887" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:30:57Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036272", "lbl" : "response to gemcitabine", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.", "xrefs" : [ "GOC:hp", "Wikipedia:Gemcitabine" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to 2',2'-difluorodeoxycytidine", "xrefs" : [ "CHEBI:175901" ] }, { "pred" : "hasExactSynonym", "val" : "response to 2'-deoxy-2',2'-difluorocytidine", "xrefs" : [ "CHEBI:175901" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:36:03Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036273", "lbl" : "response to statin", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to HMG-CoA reductase inhibitor", "xrefs" : [ "CHEBI:35664" ] }, { "pred" : "hasRelatedSynonym", "val" : "response to hydroxymethylglutaryl-CoA reductase inhibitor", "xrefs" : [ "CHEBI:35664" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:54:01Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036274", "lbl" : "response to lapatinib", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:02:26Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036275", "lbl" : "response to 5-fluorouracil", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to 5-fluoropyrimidine-2,4(1H,3H)-dione", "xrefs" : [ "CHEBI:46345" ] }, { "pred" : "hasExactSynonym", "val" : "response to fluorouracil", "xrefs" : [ "GOC:hp" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:08:23Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036276", "lbl" : "response to antidepressant", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:12:44Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036277", "lbl" : "response to anticonvulsant", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:40:12Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036287", "lbl" : "response to iloperidone", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-16T05:01:29Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036288", "lbl" : "response to ximelagatran", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-16T05:03:56Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042221", "lbl" : "response to chemical", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to chemical stimulus", "xrefs" : [ "GOC:dos" ] }, { "pred" : "hasExactSynonym", "val" : "response to chemical substance" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042710", "lbl" : "biofilm formation", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.", "xrefs" : [ "GOC:di", "PMID:11932229" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17727" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044848", "lbl" : "biological phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A distinct period or stage in a biological process or cycle.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-07-16T13:12:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048583", "lbl" : "regulation of response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", "xrefs" : [ "GOC:jid" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048584", "lbl" : "positive regulation of response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", "xrefs" : [ "GOC:jid" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "upregulation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "activation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048585", "lbl" : "negative regulation of response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", "xrefs" : [ "GOC:jid" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "downregulation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050896", "lbl" : "response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.", "xrefs" : [ "GOC:ai", "GOC:bf" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "physiological response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0051869" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051338", "lbl" : "regulation of transferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.", "xrefs" : [ "GOC:ai" ] }, "comments" : [ "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "transferase regulator" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051347", "lbl" : "positive regulation of transferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.", "xrefs" : [ "GOC:ai" ] }, "comments" : [ "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "transferase activator" }, { "pred" : "hasExactSynonym", "val" : "up regulation of transferase activity" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of transferase activity" }, { "pred" : "hasExactSynonym", "val" : "upregulation of transferase activity" }, { "pred" : "hasNarrowSynonym", "val" : "activation of transferase activity" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of transferase activity" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051348", "lbl" : "negative regulation of transferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.", "xrefs" : [ "GOC:ai" ] }, "comments" : [ "This term is useful for grouping, but is too general for manual annotation. Please use a child term instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of transferase activity" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of transferase activity" }, { "pred" : "hasExactSynonym", "val" : "downregulation of transferase activity" }, { "pred" : "hasExactSynonym", "val" : "transferase inhibitor" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of transferase activity" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051716", "lbl" : "cellular response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.", "xrefs" : [ "GOC:bf", "GOC:jl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060089", "lbl" : "molecular transducer activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A compound molecular function in which an effector function is controlled by one or more regulatory components.", "xrefs" : [ "GOC:dos", "GOC:pdt" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070603", "lbl" : "SWI/SNF superfamily-type complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.", "xrefs" : [ "GOC:bhm", "GOC:krc", "GOC:mah", "PMID:16155938" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "BAF-type complex" }, { "pred" : "hasExactSynonym", "val" : "SWI-SNF-type complex", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "SWI-SNF global transcription activator complex", "xrefs" : [ "CORUM:224" ] }, { "pred" : "hasRelatedSynonym", "val" : "SWI/SNF-type complex", "xrefs" : [ "GOC:krc" ] }, { "pred" : "hasRelatedSynonym", "val" : "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex", "xrefs" : [ "GOC:krc" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-04-29T12:55:46Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0090544" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070887", "lbl" : "cellular response to chemical stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-08-27T04:41:45Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071173", "lbl" : "spindle assembly checkpoint signaling", "type" : "CLASS", "meta" : { "definition" : { "val" : "A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "SAC", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in spindle assembly checkpoint" }, { "pred" : "hasExactSynonym", "val" : "spindle assembly checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20935" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-11-23T12:36:57Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072486" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071174", "lbl" : "mitotic spindle checkpoint signaling", "type" : "CLASS", "meta" : { "definition" : { "val" : "A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mitotic cell cycle spindle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "mitotic spindle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in mitotic cell cycle spindle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in mitotic spindle checkpoint" }, { "pred" : "hasRelatedSynonym", "val" : "topo II checkpoint" }, { "pred" : "hasRelatedSynonym", "val" : "topoisomerase II checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20935" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-11-23T12:41:36Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072477" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071214", "lbl" : "cellular response to abiotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cellular response to abiotic stress", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-03T01:02:11Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071216", "lbl" : "cellular response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cellular response to biotic stress", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-03T01:09:08Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071229", "lbl" : "cellular response to acid chemical", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.", "xrefs" : [ "GOC:go_curators", "GOC:mah", "Wikipedia:Acid" ] }, "comments" : [ "This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "cellular response to acid" }, { "pred" : "hasRelatedSynonym", "val" : "cellular response to acid anion" }, { "pred" : "hasRelatedSynonym", "val" : "cellular response to oxoanion" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-03T02:07:23Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071411", "lbl" : "cellular response to fluoxetine", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.", "xrefs" : [ "GOC:mah", "GOC:pr" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-14T03:09:58Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071495", "lbl" : "cellular response to endogenous stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-18T02:25:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071496", "lbl" : "cellular response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-18T02:36:52Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080134", "lbl" : "regulation of response to stress", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:dhl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dhl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-05-06T04:51:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090231", "lbl" : "regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090232", "lbl" : "positive regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "spindle checkpoint activation", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090233", "lbl" : "negative regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "spindle checkpoint silencing", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097366", "lbl" : "response to bronchodilator", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to bronchodilator agent" }, { "pred" : "hasRelatedSynonym", "val" : "response to broncholytic agent" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-08-01T16:13:31Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098590", "lbl" : "plasma membrane region", "type" : "CLASS", "meta" : { "definition" : { "val" : "A membrane that is a (regional) part of the plasma membrane.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "region of plasma membrane" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dos" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-03-06T11:55:32Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098798", "lbl" : "mitochondrial protein-containing complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A protein complex that is part of a mitochondrion.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "mitochondrial protein complex" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098802", "lbl" : "plasma membrane signaling receptor complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099134", "lbl" : "chimeric sorocarp development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development of a sorocarp formed by aggregation of cells with different genotypes.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099135", "lbl" : "chimeric colonial development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099136", "lbl" : "chimeric non-reproductive fruiting body development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110100", "lbl" : "spindle pole body separation", "type" : "CLASS", "meta" : { "definition" : { "val" : "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.", "xrefs" : [ "GOC:vw" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "kmv" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2018-03-06T15:09:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901976", "lbl" : "regulation of cell cycle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of cell cycle checkpoint.", "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "PMID:23028116" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "regulation of G1/S checkpoint", "xrefs" : [ "GOC:obol" ] }, { "pred" : "hasRelatedSynonym", "val" : "regulation of G1/S transition checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-03-06T15:10:20Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:2001047" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901977", "lbl" : "negative regulation of cell cycle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.", "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "PMID:23028116" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of cell cycle checkpoint", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "down-regulation of cell cycle checkpoint", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "downregulation of cell cycle checkpoint", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of cell cycle checkpoint", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "negative regulation of G1/S checkpoint", "xrefs" : [ "GOC:obol" ] }, { "pred" : "hasRelatedSynonym", "val" : "negative regulation of G1/S transition checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-03-06T15:10:29Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:2001048" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902518", "lbl" : "response to cyclophosphamide", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.", "xrefs" : [ "GOC:TermGenie", "GOC:dw", "PMID:23648065" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dw" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-02T09:34:08Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902519", "lbl" : "response to docetaxel trihydrate", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus.", "xrefs" : [ "GOC:TermGenie", "GOC:dw", "PMID:23648065" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to docetaxel" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dw" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-02T09:44:04Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902520", "lbl" : "response to doxorubicin", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus.", "xrefs" : [ "GOC:TermGenie", "GOC:dw", "PMID:23648065" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dw" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-02T09:44:13Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902521", "lbl" : "response to etoposide", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus.", "xrefs" : [ "GOC:TermGenie", "GOC:dw", "PMID:23648065" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. 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