gocheck do not manually annotate.owl
type: Ontology
version IRI: gocheck do not manually annotate.owl
version info: 2024-01-26

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: FlyBase Drosophila GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

cytokinesis
type: Class
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Wikipedia:Cytokinesis
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
has_obo_namespace: biological_process
id: GO:0000910
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other.

Axiom
annotated source: cytokinesis
annotated property: definition
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
database_cross_reference: GOC:mtg_cell_cycle

Axiom
annotated source: cytokinesis
annotated property: has_exact_synonym
annotated target: cytokinesis involved in cell cycle
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

response to acid chemical
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
has_broad_synonym: response to acid
has_obo_namespace: biological_process
has_related_synonym: response to acid anion
has_related_synonym: response to oxoanion
id: GO:0001101
in_subset: gocheck do not manually annotate
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.

Axiom
annotated source: response to acid chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:rn

cilium or flagellum-dependent cell motility
type: Class
definition: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
has_exact_synonym: ciliary/flagellar motility
has_obo_namespace: biological_process
has_related_synonym: ciliary or bacterial-type flagellar motility
id: GO:0001539
in_subset: gocheck do not manually annotate
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.

Axiom
annotated source: cilium or flagellum-dependent cell motility
annotated property: definition
annotated target: Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:hjd
database_cross_reference: GOC:krc

regulation of response to biotic stimulus
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to biotic stimulus
definition: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
has_obo_namespace: biological_process
id: GO:0002831
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

negative regulation of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to biotic stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: down regulation of response to biotic stimulus
has_exact_synonym: down-regulation of response to biotic stimulus
has_exact_synonym: downregulation of response to biotic stimulus
has_narrow_synonym: inhibition of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002832
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

positive regulation of response to biotic stimulus
type: Class
subclass of: regulation of response to biotic stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to biotic stimulus
definition: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
has_exact_synonym: up regulation of response to biotic stimulus
has_exact_synonym: up-regulation of response to biotic stimulus
has_exact_synonym: upregulation of response to biotic stimulus
has_narrow_synonym: activation of response to biotic stimulus
has_narrow_synonym: stimulation of response to biotic stimulus
has_obo_namespace: biological_process
id: GO:0002833
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to biotic stimulus
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
database_cross_reference: GOC:add

response to stress
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
id: GO:0006950
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

cell cycle
type: Class
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle

behavior
type: Class
definition: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
created by: jl
creation date: 2012-09-20T14:06:08Z
has_alternative_id: GO:0023032
has_alternative_id: GO:0044708
has_alternative_id: GO:0044709
database_cross_reference: Wikipedia:Behavior
has_exact_synonym: behavioral response to stimulus
has_exact_synonym: behaviour
has_exact_synonym: behavioural response to stimulus
has_obo_namespace: biological_process
has_related_synonym: single-organism behavior
id: GO:0007610
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).

Axiom
annotated source: behavior
annotated property: definition
annotated target: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
database_cross_reference: GOC:ems
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395448956
database_cross_reference: PMID:20160973

metabolic process
type: Class
disjoint with: biological phase
definition: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
created by: jl
creation date: 2012-10-17T15:46:40Z
has_alternative_id: GO:0044236
has_alternative_id: GO:0044710
database_cross_reference: Wikipedia:Metabolism
has_exact_synonym: metabolism
has_narrow_synonym: metabolic process resulting in cell growth
has_narrow_synonym: metabolism resulting in cell growth
has_narrow_synonym: multicellular organism metabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism metabolic process
id: GO:0008152
in_subset: gocheck do not manually annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

Axiom
annotated source: metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198547684

response to external stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
has_exact_synonym: response to environmental stimulus
has_obo_namespace: biological_process
id: GO:0009605
in_subset: gocheck do not manually annotate
in_subset: goslim drosophila
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:hb

response to biotic stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
has_narrow_synonym: response to biotic stress
has_obo_namespace: biological_process
id: GO:0009607
in_subset: gocheck do not manually annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
database_cross_reference: GOC:hb

response to abiotic stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
term tracker item: https://github.com/geneontology/go-ontology/issues/16572
has_narrow_synonym: response to abiotic stress
has_obo_namespace: biological_process
id: GO:0009628
in_subset: gocheck do not manually annotate
in_subset: goslim metagenomics
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to abiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
database_cross_reference: GOC:hb

response to endogenous stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
has_obo_namespace: biological_process
id: GO:0009719
in_subset: gocheck do not manually annotate
in_subset: goslim plant
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to endogenous stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
database_cross_reference: GOC:sm

embryo development
type: Class
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790
in_subset: gocheck do not manually annotate
in_subset: goslim chembl
in_subset: goslim plant

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

response to fluoxetine
type: Class
subclass of: response to antidepressant
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
has_obo_namespace: biological_process
has_related_synonym: response to SSRI
has_related_synonym: response to selective serotonin reuptake inhibitor
id: GO:0014076
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to fluoxetine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
database_cross_reference: GOC:ef
database_cross_reference: GOC:pr

spindle checkpoint signaling
type: Class
subclass of: Restriction
  on property: part of
  some values from: cellular response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: cell cycle
subclass of: Restriction
  on property: negatively regulates
  some values from: cell cycle
definition: A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
has_alternative_id: GO:0072416
database_cross_reference: Wikipedia:Spindle_checkpoint
has_exact_synonym: signal transduction involved in spindle checkpoint
has_exact_synonym: spindle checkpoint
has_obo_namespace: biological_process
id: GO:0031577
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term.

Axiom
annotated source: spindle checkpoint signaling
annotated property: definition
annotated target: A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.
database_cross_reference: GOC:mtg_cell_cycle

regulation of response to external stimulus
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to external stimulus
definition: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
has_obo_namespace: biological_process
id: GO:0032101
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to external stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

negative regulation of response to external stimulus
type: Class
subclass of: regulation of response to external stimulus
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to external stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
has_exact_synonym: down regulation of response to external stimulus
has_exact_synonym: down-regulation of response to external stimulus
has_exact_synonym: downregulation of response to external stimulus
has_narrow_synonym: inhibition of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032102
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to external stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
database_cross_reference: GOC:mah

positive regulation of response to external stimulus
type: Class
subclass of: regulation of response to external stimulus
subclass of: positive regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to external stimulus
definition: Any process that activates, maintains or increases the rate of a response to an external stimulus.
has_exact_synonym: up regulation of response to external stimulus
has_exact_synonym: up-regulation of response to external stimulus
has_exact_synonym: upregulation of response to external stimulus
has_narrow_synonym: activation of response to external stimulus
has_narrow_synonym: stimulation of response to external stimulus
has_obo_namespace: biological_process
id: GO:0032103
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to external stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to an external stimulus.
database_cross_reference: GOC:mah

cellular response to stress
type: Class
subclass of: response to stress
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
has_obo_namespace: biological_process
id: GO:0033554
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

response to diuretic
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
created by: bf
creation date: 2012-07-09T01:26:24Z
has_obo_namespace: biological_process
id: GO:0036270
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to diuretic
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.
database_cross_reference: GOC:hp

response to methylphenidate
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
created by: bf
creation date: 2012-07-09T01:30:57Z
has_exact_synonym: response to MPD
has_exact_synonym: response to MPH
has_exact_synonym: response to ritalin
has_obo_namespace: biological_process
id: GO:0036271
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to methylphenidate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Methylphenidate

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPD
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to MPH
database_cross_reference: CHEBI:6887

Axiom
annotated source: response to methylphenidate
annotated property: has_exact_synonym
annotated target: response to ritalin
database_cross_reference: CHEBI:6887

response to gemcitabine
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
created by: bf
creation date: 2012-07-09T01:36:03Z
has_exact_synonym: response to 2',2'-difluorodeoxycytidine
has_exact_synonym: response to 2'-deoxy-2',2'-difluorocytidine
has_obo_namespace: biological_process
id: GO:0036272
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to gemcitabine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.
database_cross_reference: GOC:hp
database_cross_reference: Wikipedia:Gemcitabine

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2',2'-difluorodeoxycytidine
database_cross_reference: CHEBI:175901

Axiom
annotated source: response to gemcitabine
annotated property: has_exact_synonym
annotated target: response to 2'-deoxy-2',2'-difluorocytidine
database_cross_reference: CHEBI:175901

response to statin
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
created by: bf
creation date: 2012-07-09T01:54:01Z
has_obo_namespace: biological_process
has_related_synonym: response to HMG-CoA reductase inhibitor
has_related_synonym: response to hydroxymethylglutaryl-CoA reductase inhibitor
id: GO:0036273
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to statin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
database_cross_reference: GOC:hp

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to HMG-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

Axiom
annotated source: response to statin
annotated property: has_related_synonym
annotated target: response to hydroxymethylglutaryl-CoA reductase inhibitor
database_cross_reference: CHEBI:35664

response to lapatinib
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
created by: bf
creation date: 2012-07-09T02:02:26Z
has_obo_namespace: biological_process
id: GO:0036274
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to lapatinib
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.
database_cross_reference: GOC:hp

response to 5-fluorouracil
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
created by: bf
creation date: 2012-07-09T02:08:23Z
has_exact_synonym: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
has_exact_synonym: response to fluorouracil
has_obo_namespace: biological_process
id: GO:0036275
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to 5-fluorouracil
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.
database_cross_reference: GOC:hp

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to 5-fluoropyrimidine-2,4(1H,3H)-dione
database_cross_reference: CHEBI:46345

Axiom
annotated source: response to 5-fluorouracil
annotated property: has_exact_synonym
annotated target: response to fluorouracil
database_cross_reference: GOC:hp

response to antidepressant
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
created by: bf
creation date: 2012-07-09T02:12:44Z
has_obo_namespace: biological_process
id: GO:0036276
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to antidepressant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.
database_cross_reference: GOC:hp

response to anticonvulsant
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
created by: bf
creation date: 2012-07-09T02:40:12Z
has_obo_namespace: biological_process
id: GO:0036277
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to anticonvulsant
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.
database_cross_reference: GOC:hp

response to iloperidone
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
created by: bf
creation date: 2012-07-16T05:01:29Z
has_obo_namespace: biological_process
id: GO:0036287
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to iloperidone
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.
database_cross_reference: GOC:hp

response to ximelagatran
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
created by: bf
creation date: 2012-07-16T05:03:56Z
has_obo_namespace: biological_process
id: GO:0036288
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to ximelagatran
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.
database_cross_reference: GOC:hp

response to chemical
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
has_exact_synonym: response to chemical stimulus
has_exact_synonym: response to chemical substance
has_obo_namespace: biological_process
id: GO:0042221
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:jl

Axiom
annotated source: response to chemical
annotated property: has_exact_synonym
annotated target: response to chemical stimulus
database_cross_reference: GOC:dos

biofilm formation
type: Class
definition: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/17727
has_obo_namespace: biological_process
id: GO:0042710
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim pir

Axiom
annotated source: biofilm formation
annotated property: definition
annotated target: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
database_cross_reference: GOC:di
database_cross_reference: PMID:11932229

biological phase
type: Class
disjoint with: response to stimulus
definition: A distinct period or stage in a biological process or cycle.
created by: jl
creation date: 2014-07-16T13:12:40Z
has_obo_namespace: biological_process
id: GO:0044848
in_subset: gocheck do not manually annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

Axiom
annotated source: biological phase
annotated property: definition
annotated target: A distinct period or stage in a biological process or cycle.
database_cross_reference: GOC:jl

regulation of response to stimulus
type: Class
subclass of: Restriction
  on property: regulates
  some values from: response to stimulus
definition: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_obo_namespace: biological_process
id: GO:0048583
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to stimulus
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

positive regulation of response to stimulus
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: positively regulates
  some values from: response to stimulus
definition: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: up regulation of response to stimulus
has_exact_synonym: up-regulation of response to stimulus
has_exact_synonym: upregulation of response to stimulus
has_narrow_synonym: activation of response to stimulus
has_narrow_synonym: stimulation of response to stimulus
has_obo_namespace: biological_process
id: GO:0048584
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: positive regulation of response to stimulus
annotated property: definition
annotated target: Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

negative regulation of response to stimulus
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: negatively regulates
  some values from: response to stimulus
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
has_exact_synonym: down regulation of response to stimulus
has_exact_synonym: down-regulation of response to stimulus
has_exact_synonym: downregulation of response to stimulus
has_narrow_synonym: inhibition of response to stimulus
has_obo_namespace: biological_process
id: GO:0048585
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: negative regulation of response to stimulus
annotated property: definition
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid

response to stimulus
type: Class
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
has_alternative_id: GO:0051869
has_exact_synonym: physiological response to stimulus
has_obo_namespace: biological_process
id: GO:0050896
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf

regulation of transferase activity
type: Class
definition: Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
has_exact_synonym: transferase regulator
has_obo_namespace: biological_process
id: GO:0051338
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.

Axiom
annotated source: regulation of transferase activity
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: GOC:ai

positive regulation of transferase activity
type: Class
subclass of: regulation of transferase activity
definition: Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.
has_exact_synonym: transferase activator
has_exact_synonym: up regulation of transferase activity
has_exact_synonym: up-regulation of transferase activity
has_exact_synonym: upregulation of transferase activity
has_narrow_synonym: activation of transferase activity
has_narrow_synonym: stimulation of transferase activity
has_obo_namespace: biological_process
id: GO:0051347
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.

Axiom
annotated source: positive regulation of transferase activity
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.
database_cross_reference: GOC:ai

negative regulation of transferase activity
type: Class
subclass of: regulation of transferase activity
definition: Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.
has_exact_synonym: down regulation of transferase activity
has_exact_synonym: down-regulation of transferase activity
has_exact_synonym: downregulation of transferase activity
has_exact_synonym: transferase inhibitor
has_narrow_synonym: inhibition of transferase activity
has_obo_namespace: biological_process
id: GO:0051348
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.

Axiom
annotated source: negative regulation of transferase activity
annotated property: definition
annotated target: Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.
database_cross_reference: GOC:ai

cellular response to stimulus
type: Class
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
has_obo_namespace: biological_process
id: GO:0051716
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

molecular transducer activity
type: Class
definition: A compound molecular function in which an effector function is controlled by one or more regulatory components.
has_obo_namespace: molecular_function
id: GO:0060089
in_subset: gocheck do not manually annotate
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: molecular transducer activity
annotated property: definition
annotated target: A compound molecular function in which an effector function is controlled by one or more regulatory components.
database_cross_reference: GOC:dos
database_cross_reference: GOC:pdt

SWI/SNF superfamily-type complex
type: Class
definition: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.
created by: mah
creation date: 2009-04-29T12:55:46Z
has_alternative_id: GO:0090544
has_exact_synonym: BAF-type complex
has_exact_synonym: SWI-SNF-type complex
has_obo_namespace: cellular_component
has_related_synonym: SWI-SNF global transcription activator complex
has_related_synonym: SWI/SNF-type complex
has_related_synonym: SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex
id: GO:0070603
in_subset: gocheck do not manually annotate

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: definition
annotated target: A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.
database_cross_reference: GOC:bhm
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah
database_cross_reference: PMID:16155938

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_exact_synonym
annotated target: SWI-SNF-type complex
database_cross_reference: GOC:mah

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI-SNF global transcription activator complex
database_cross_reference: CORUM:224

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI/SNF-type complex
database_cross_reference: GOC:krc

Axiom
annotated source: SWI/SNF superfamily-type complex
annotated property: has_related_synonym
annotated target: SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex
database_cross_reference: GOC:krc

cellular response to chemical stimulus
type: Class
subclass of: response to chemical
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
created by: mah
creation date: 2009-08-27T04:41:45Z
has_obo_namespace: biological_process
id: GO:0070887
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to chemical stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
database_cross_reference: GOC:mah

spindle assembly checkpoint signaling
type: Class
subclass of: spindle checkpoint signaling
definition: A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
created by: mah
creation date: 2009-11-23T12:36:57Z
has_alternative_id: GO:0072486
has_broad_synonym: SAC
has_exact_synonym: signal transduction involved in spindle assembly checkpoint
has_exact_synonym: spindle assembly checkpoint
has_obo_namespace: biological_process
id: GO:0071173
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic).

Axiom
annotated source: spindle assembly checkpoint signaling
annotated property: definition
annotated target: A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.
database_cross_reference: GOC:mah

Axiom
annotated source: spindle assembly checkpoint signaling
annotated property: has_broad_synonym
annotated target: SAC
database_cross_reference: GOC:mah

mitotic spindle checkpoint signaling
type: Class
subclass of: spindle checkpoint signaling
definition: A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.
term tracker item: https://github.com/geneontology/go-ontology/issues/20935
created by: mah
creation date: 2009-11-23T12:41:36Z
has_alternative_id: GO:0072477
has_exact_synonym: mitotic cell cycle spindle checkpoint
has_exact_synonym: mitotic spindle checkpoint
has_exact_synonym: signal transduction involved in mitotic cell cycle spindle checkpoint
has_exact_synonym: signal transduction involved in mitotic spindle checkpoint
has_obo_namespace: biological_process
has_related_synonym: topo II checkpoint
has_related_synonym: topoisomerase II checkpoint
id: GO:0071174
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints).

Axiom
annotated source: mitotic spindle checkpoint signaling
annotated property: definition
annotated target: A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.
database_cross_reference: GOC:mtg_cell_cycle

cellular response to abiotic stimulus
type: Class
subclass of: response to abiotic stimulus
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.
created by: mah
creation date: 2009-12-03T01:02:11Z
has_narrow_synonym: cellular response to abiotic stress
has_obo_namespace: biological_process
id: GO:0071214
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to abiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular response to abiotic stimulus
annotated property: has_narrow_synonym
annotated target: cellular response to abiotic stress
database_cross_reference: GOC:mah

cellular response to biotic stimulus
type: Class
subclass of: response to biotic stimulus
subclass of: cellular response to stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
created by: mah
creation date: 2009-12-03T01:09:08Z
has_narrow_synonym: cellular response to biotic stress
has_obo_namespace: biological_process
id: GO:0071216
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to biotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
database_cross_reference: GOC:mah

Axiom
annotated source: cellular response to biotic stimulus
annotated property: has_narrow_synonym
annotated target: cellular response to biotic stress
database_cross_reference: GOC:mah

cellular response to acid chemical
type: Class
subclass of: response to acid chemical
subclass of: cellular response to chemical stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
created by: mah
creation date: 2009-12-03T02:07:23Z
has_broad_synonym: cellular response to acid
has_obo_namespace: biological_process
has_related_synonym: cellular response to acid anion
has_related_synonym: cellular response to oxoanion
id: GO:0071229
in_subset: gocheck do not manually annotate
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.

Axiom
annotated source: cellular response to acid chemical
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mah
database_cross_reference: Wikipedia:Acid

cellular response to fluoxetine
type: Class
subclass of: response to fluoxetine
subclass of: cellular response to chemical stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
created by: mah
creation date: 2009-12-14T03:09:58Z
has_obo_namespace: biological_process
id: GO:0071411
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to fluoxetine
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr

cellular response to endogenous stimulus
type: Class
subclass of: response to endogenous stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
created by: mah
creation date: 2009-12-18T02:25:40Z
has_obo_namespace: biological_process
id: GO:0071495
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to endogenous stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
database_cross_reference: GOC:mah

cellular response to external stimulus
type: Class
subclass of: response to external stimulus
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
created by: mah
creation date: 2009-12-18T02:36:52Z
has_obo_namespace: biological_process
id: GO:0071496
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to external stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
database_cross_reference: GOC:mah

regulation of response to stress
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: response to stress
definition: Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
created by: dhl
creation date: 2009-05-06T04:51:28Z
has_obo_namespace: biological_process
id: GO:0080134
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: regulation of response to stress
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:dhl

regulation of spindle checkpoint
type: Class
subclass of: regulation of cell cycle checkpoint
subclass of: Restriction
  on property: regulates
  some values from: spindle checkpoint signaling
definition: Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_obo_namespace: biological_process
id: GO:0090231
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

positive regulation of spindle checkpoint
type: Class
subclass of: positive regulation of response to stimulus
subclass of: regulation of spindle checkpoint
subclass of: Restriction
  on property: positively regulates
  some values from: spindle checkpoint signaling
definition: Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_narrow_synonym: spindle checkpoint activation
has_obo_namespace: biological_process
id: GO:0090232
in_subset: gocheck do not manually annotate

Axiom
annotated source: positive regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: positive regulation of spindle checkpoint
annotated property: has_narrow_synonym
annotated target: spindle checkpoint activation
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

negative regulation of spindle checkpoint
type: Class
subclass of: regulation of spindle checkpoint
subclass of: negative regulation of cell cycle checkpoint
subclass of: Restriction
  on property: negatively regulates
  some values from: spindle checkpoint signaling
definition: Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
created by: tb
creation date: 2010-01-20T10:29:43Z
has_narrow_synonym: spindle checkpoint silencing
has_obo_namespace: biological_process
id: GO:0090233
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: negative regulation of spindle checkpoint
annotated property: definition
annotated target: Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Axiom
annotated source: negative regulation of spindle checkpoint
annotated property: has_narrow_synonym
annotated target: spindle checkpoint silencing
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

response to bronchodilator
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.
created by: pr
creation date: 2012-08-01T16:13:31Z
has_exact_synonym: response to bronchodilator agent
has_obo_namespace: biological_process
has_related_synonym: response to broncholytic agent
id: GO:0097366
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to bronchodilator
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.
database_cross_reference: GOC:hp

plasma membrane region
type: Class
definition: A membrane that is a (regional) part of the plasma membrane.
created by: dos
creation date: 2014-03-06T11:55:32Z
has_exact_synonym: region of plasma membrane
has_obo_namespace: cellular_component
id: GO:0098590
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.

Axiom
annotated source: plasma membrane region
annotated property: definition
annotated target: A membrane that is a (regional) part of the plasma membrane.
database_cross_reference: GOC:dos

mitochondrial protein-containing complex
type: Class
definition: A protein complex that is part of a mitochondrion.
has_obo_namespace: cellular_component
has_related_synonym: mitochondrial protein complex
id: GO:0098798
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: mitochondrial protein-containing complex
annotated property: definition
annotated target: A protein complex that is part of a mitochondrion.
database_cross_reference: GOC:dos

plasma membrane signaling receptor complex
type: Class
definition: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.
has_obo_namespace: cellular_component
id: GO:0098802
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: plasma membrane signaling receptor complex
annotated property: definition
annotated target: Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.
database_cross_reference: GOC:dos

chimeric sorocarp development
type: Class
subclass of: chimeric non-reproductive fruiting body development
definition: Development of a sorocarp formed by aggregation of cells with different genotypes.
has_obo_namespace: biological_process
id: GO:0099134
in_subset: gocheck do not manually annotate

Axiom
annotated source: chimeric sorocarp development
annotated property: definition
annotated target: Development of a sorocarp formed by aggregation of cells with different genotypes.
database_cross_reference: PMID:18272966

chimeric colonial development
type: Class
definition: Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.
has_obo_namespace: biological_process
id: GO:0099135
in_subset: gocheck do not manually annotate

Axiom
annotated source: chimeric colonial development
annotated property: definition
annotated target: Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.
database_cross_reference: PMID:18272966

chimeric non-reproductive fruiting body development
type: Class
subclass of: chimeric colonial development
definition: Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.
has_obo_namespace: biological_process
id: GO:0099136
in_subset: gocheck do not manually annotate

Axiom
annotated source: chimeric non-reproductive fruiting body development
annotated property: definition
annotated target: Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.
database_cross_reference: PMID:18272966

spindle pole body separation
type: Class
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.
created by: kmv
creation date: 2018-03-06T15:09:28Z
has_obo_namespace: biological_process
id: GO:0110100
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: spindle pole body separation
annotated property: definition
annotated target: The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.
database_cross_reference: GOC:vw

regulation of cell cycle checkpoint
type: Class
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: cell cycle
definition: Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
created by: jl
creation date: 2013-03-06T15:10:20Z
has_alternative_id: GO:2001047
has_obo_namespace: biological_process
has_related_synonym: regulation of G1/S checkpoint
has_related_synonym: regulation of G1/S transition checkpoint
id: GO:1901976
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: regulation of cell cycle checkpoint
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: PMID:23028116

Axiom
annotated source: regulation of cell cycle checkpoint
annotated property: has_related_synonym
annotated target: regulation of G1/S checkpoint
database_cross_reference: GOC:obol

negative regulation of cell cycle checkpoint
type: Class
subclass of: negative regulation of response to stimulus
subclass of: regulation of cell cycle checkpoint
subclass of: Restriction
  on property: positively regulates
  some values from: cell cycle
definition: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.
created by: jl
creation date: 2013-03-06T15:10:29Z
has_alternative_id: GO:2001048
has_exact_synonym: down regulation of cell cycle checkpoint
has_exact_synonym: down-regulation of cell cycle checkpoint
has_exact_synonym: downregulation of cell cycle checkpoint
has_narrow_synonym: inhibition of cell cycle checkpoint
has_obo_namespace: biological_process
has_related_synonym: negative regulation of G1/S checkpoint
has_related_synonym: negative regulation of G1/S transition checkpoint
id: GO:1901977
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: definition
annotated target: Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: PMID:23028116

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: down regulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: down-regulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_exact_synonym
annotated target: downregulation of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_narrow_synonym
annotated target: inhibition of cell cycle checkpoint
database_cross_reference: GOC:TermGenie

Axiom
annotated source: negative regulation of cell cycle checkpoint
annotated property: has_related_synonym
annotated target: negative regulation of G1/S checkpoint
database_cross_reference: GOC:obol

response to cyclophosphamide
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.
created by: dw
creation date: 2013-12-02T09:34:08Z
has_obo_namespace: biological_process
id: GO:1902518
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to cyclophosphamide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to docetaxel trihydrate
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus.
created by: dw
creation date: 2013-12-02T09:44:04Z
has_obo_namespace: biological_process
has_related_synonym: response to docetaxel
id: GO:1902519
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to docetaxel trihydrate
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to doxorubicin
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus.
created by: dw
creation date: 2013-12-02T09:44:13Z
has_obo_namespace: biological_process
id: GO:1902520
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to doxorubicin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to etoposide
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus.
created by: dw
creation date: 2013-12-02T09:44:22Z
has_obo_namespace: biological_process
id: GO:1902521
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to etoposide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to 4'-epidoxorubicin
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus.
created by: dw
creation date: 2013-12-02T09:44:31Z
has_obo_namespace: biological_process
has_related_synonym: response to epirubicin
id: GO:1902522
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to 4'-epidoxorubicin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: PMID:23648065

response to simvastatin
type: Class
subclass of: response to statin
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug.
created by: hp
creation date: 2014-09-25T10:58:06Z
has_obo_namespace: biological_process
id: GO:1903491
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to simvastatin
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:sl
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:23100282

regulation of mitotic spindle checkpoint
type: Class
subclass of: regulation of spindle checkpoint
subclass of: Restriction
  on property: regulates
  some values from: mitotic spindle checkpoint signaling
definition: Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint.
created by: al
creation date: 2014-10-01T13:52:57Z
has_exact_synonym: regulation of mitotic cell cycle spindle checkpoint
has_obo_namespace: biological_process
id: GO:1903504
in_subset: gocheck do not manually annotate
comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent).

Axiom
annotated source: regulation of mitotic spindle checkpoint
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint.
database_cross_reference: GOC:TermGenie
database_cross_reference: GO_REF:0000058
database_cross_reference: PMID:23442800

Axiom
annotated source: regulation of mitotic spindle checkpoint
annotated property: has_exact_synonym
annotated target: regulation of mitotic cell cycle spindle checkpoint
database_cross_reference: GOC:TermGenie

response to haloperidol
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
created by: dw
creation date: 2016-04-08T12:36:39Z
has_obo_namespace: biological_process
id: GO:1905119
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to haloperidol
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:24751813

cellular response to haloperidol
type: Class
subclass of: cellular response to chemical stimulus
subclass of: cellular response to endogenous stimulus
subclass of: response to haloperidol
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
created by: dw
creation date: 2016-04-08T12:36:47Z
has_obo_namespace: biological_process
id: GO:1905120
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: cellular response to haloperidol
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus.
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:dw
database_cross_reference: GO_REF:0000071
database_cross_reference: PMID:24751813

response to temozolomide
type: Class
subclass of: response to chemical
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus.
created by: pr
creation date: 2013-02-22T10:09:44Z
has_obo_namespace: biological_process
id: GO:1990054
in_subset: gocheck do not manually annotate
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.

Axiom
annotated source: response to temozolomide
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus.
database_cross_reference: GOC:hp

preceded by
database_cross_reference: BFO:0000062
has_obo_namespace: external
id: preceded_by
shorthand: preceded_by

precedes
database_cross_reference: BFO:0000063
has_obo_namespace: external
id: precedes
shorthand: precedes

results in
created by: cjm
creation date: 2012-03-14T10:35:44Z
database_cross_reference: GOREL:0000040
has_obo_namespace: external
id: results_in
shorthand: results_in
comment: This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.

results in division of
database_cross_reference: GOREL:0001019
has_obo_namespace: external
id: results_in_division_of
shorthand: results_in_division_of
comment: use occurs_in

results in distribution of
database_cross_reference: GOREL:0002003
has_obo_namespace: external
id: results_in_distribution_of
shorthand: results_in_distribution_of

results in fission of
database_cross_reference: GOREL:0002004
has_obo_namespace: external
id: results_in_fission_of
shorthand: results_in_fission_of

results in maintenance of
database_cross_reference: GOREL:0012006
has_obo_namespace: external
id: results_in_maintenance_of
shorthand: results_in_maintenance_of

bearer of
database_cross_reference: RO:0000053
has_obo_namespace: external
id: bearer_of
shorthand: bearer_of

participates in
database_cross_reference: RO:0000056
has_obo_namespace: external
id: participates_in
shorthand: participates_in

has participant
database_cross_reference: RO:0000057
has_obo_namespace: external
id: has_participant
shorthand: has_participant

bounding layer of
database_cross_reference: RO:0002007
has_obo_namespace: external
id: bounding_layer_of
shorthand: bounding_layer_of

coincident with
database_cross_reference: RO:0002008
has_obo_namespace: external
id: coincident_with
shorthand: coincident_with

regulates in other organism
database_cross_reference: RO:0002010
has_obo_namespace: external
id: regulates_in_other_organism
shorthand: regulates_in_other_organism

has regulatory component activity
database_cross_reference: RO:0002013
has_obo_namespace: external
id: has_regulatory_component_activity
shorthand: has_regulatory_component_activity

has negative regulatory component activity
database_cross_reference: RO:0002014
has_obo_namespace: external
id: has_negative_regulatory_component_activity
shorthand: has_negative_regulatory_component_activity

has necessary component activity
database_cross_reference: RO:0002016
has_obo_namespace: external
id: has_necessary_component_activity
shorthand: has_necessary_component_activity

immediately preceded by
database_cross_reference: RO:0002087
has_obo_namespace: external
id: immediately_preceded_by
shorthand: immediately_preceded_by

immediately precedes
database_cross_reference: RO:0002090
has_obo_namespace: external
id: immediately_precedes
shorthand: immediately_precedes

overlaps
database_cross_reference: RO:0002131
has_obo_namespace: external
id: overlaps
shorthand: overlaps

has component
database_cross_reference: RO:0002180
has_obo_namespace: external
id: has_component
shorthand: has_component

capable of
database_cross_reference: RO:0002215
has_obo_namespace: external
id: capable_of
shorthand: capable_of

capable of part of
database_cross_reference: RO:0002216
has_obo_namespace: external
id: capable_of_part_of
shorthand: capable_of_part_of

adjacent to
database_cross_reference: RO:0002220
has_obo_namespace: external
id: adjacent_to
shorthand: adjacent_to

starts with
database_cross_reference: RO:0002224
has_obo_namespace: external
id: starts_with
shorthand: starts_with

ends with
database_cross_reference: RO:0002230
has_obo_namespace: external
id: ends_with
shorthand: ends_with

has start location
database_cross_reference: RO:0002231
has_obo_namespace: external
id: has_start_location
shorthand: has_start_location

has end location
database_cross_reference: RO:0002232
has_obo_namespace: external
id: has_end_location
shorthand: has_end_location

has input
database_cross_reference: RO:0002233
has_obo_namespace: external
id: has_input
shorthand: has_input

has output
database_cross_reference: RO:0002234
has_obo_namespace: external
id: has_output
shorthand: has_output

results in developmental progression of
database_cross_reference: RO:0002295
has_obo_namespace: external
id: results_in_developmental_progression_of
shorthand: results_in_developmental_progression_of

results in development of
database_cross_reference: RO:0002296
has_obo_namespace: external
id: results_in_development_of
shorthand: results_in_development_of

results in formation of
database_cross_reference: RO:0002297
has_obo_namespace: external
id: results_in_formation_of
shorthand: results_in_formation_of

results in morphogenesis of
database_cross_reference: RO:0002298
has_obo_namespace: external
id: results_in_morphogenesis_of
shorthand: results_in_morphogenesis_of

results in maturation of
database_cross_reference: RO:0002299
has_obo_namespace: external
id: results_in_maturation_of
shorthand: results_in_maturation_of

causally upstream of, positive effect
database_cross_reference: RO:0002304
has_obo_namespace: external
id: causally_upstream_of,_positive_effect
shorthand: causally_upstream_of,_positive_effect

causally upstream of, negative effect
database_cross_reference: RO:0002305
has_obo_namespace: external
id: causally_upstream_of,_negative_effect
shorthand: causally_upstream_of,_negative_effect

results in acquisition of features of
database_cross_reference: RO:0002315
has_obo_namespace: external
id: results_in_acquisition_of_features_of
shorthand: results_in_acquisition_of_features_of

regulates levels of
database_cross_reference: RO:0002332
has_obo_namespace: external
id: regulates_levels_of
shorthand: regulates_levels_of

regulated by
database_cross_reference: RO:0002334
has_obo_namespace: external
id: regulated_by
shorthand: regulated_by

negatively regulated by
database_cross_reference: RO:0002335
has_obo_namespace: external
id: negatively_regulated_by
shorthand: negatively_regulated_by

positively regulated by
database_cross_reference: RO:0002336
has_obo_namespace: external
id: positively_regulated_by
shorthand: positively_regulated_by

has target start location
database_cross_reference: RO:0002338
has_obo_namespace: external
id: has_target_start_location
shorthand: has_target_start_location

has target end location
database_cross_reference: RO:0002339
has_obo_namespace: external
id: has_target_end_location
shorthand: has_target_end_location

results in transport along
database_cross_reference: RO:0002341
has_obo_namespace: external
id: results_in_transport_along
shorthand: results_in_transport_along

results in transport across
database_cross_reference: RO:0002342
has_obo_namespace: external
id: results_in_transport_across
shorthand: results_in_transport_across

results in growth of
database_cross_reference: RO:0002343
has_obo_namespace: external
id: results_in_growth_of
shorthand: results_in_growth_of

results in transport to from or in
database_cross_reference: RO:0002344
has_obo_namespace: external
id: results_in_transport_to_from_or_in
shorthand: results_in_transport_to_from_or_in

results in commitment to
database_cross_reference: RO:0002348
has_obo_namespace: external
id: results_in_commitment_to
shorthand: results_in_commitment_to

results in determination of
database_cross_reference: RO:0002349
has_obo_namespace: external
id: results_in_determination_of
shorthand: results_in_determination_of

output of
database_cross_reference: RO:0002353
has_obo_namespace: external
id: output_of
shorthand: output_of

results in structural organization of
database_cross_reference: RO:0002355
has_obo_namespace: external
id: results_in_structural_organization_of
shorthand: results_in_structural_organization_of

results in specification of
database_cross_reference: RO:0002356
has_obo_namespace: external
id: results_in_specification_of
shorthand: results_in_specification_of

causally downstream of
database_cross_reference: RO:0002404
has_obo_namespace: external
id: causally_downstream_of
shorthand: causally_downstream_of

immediately causally downstream of
database_cross_reference: RO:0002405
has_obo_namespace: external
id: immediately_causally_downstream_of
shorthand: immediately_causally_downstream_of

causally upstream of
database_cross_reference: RO:0002411
has_obo_namespace: external
id: causally_upstream_of
shorthand: causally_upstream_of

immediately causally upstream of
database_cross_reference: RO:0002412
has_obo_namespace: external
id: immediately_causally_upstream_of
shorthand: immediately_causally_upstream_of

causally upstream of or within
database_cross_reference: RO:0002418
has_obo_namespace: external
id: causally_upstream_of_or_within
shorthand: causally_upstream_of_or_within

causally downstream of or within
database_cross_reference: RO:0002427
has_obo_namespace: external
id: causally_downstream_of_or_within
shorthand: causally_downstream_of_or_within

has intermediate
database_cross_reference: RO:0002505
has_obo_namespace: external
id: has_intermediate
shorthand: has_intermediate

results in movement of
database_cross_reference: RO:0002565
has_obo_namespace: external
id: results_in_movement_of
shorthand: results_in_movement_of

directly regulates
database_cross_reference: RO:0002578
has_obo_namespace: external
id: directly_regulates
shorthand: directly_regulates

results in assembly of
database_cross_reference: RO:0002588
has_obo_namespace: external
id: results_in_assembly_of
shorthand: results_in_assembly_of

results in disassembly of
database_cross_reference: RO:0002590
has_obo_namespace: external
id: results_in_disassembly_of
shorthand: results_in_disassembly_of

results in remodeling of
database_cross_reference: RO:0002591
has_obo_namespace: external
id: results_in_remodeling_of
shorthand: results_in_remodeling_of

results in organization of
database_cross_reference: RO:0002592
has_obo_namespace: external
id: results_in_organization_of
shorthand: results_in_organization_of

process has causal agent
database_cross_reference: RO:0002608
has_obo_namespace: external
id: process_has_causal_agent
shorthand: process_has_causal_agent

directly positively regulates
database_cross_reference: RO:0002629
has_obo_namespace: external
id: directly_positively_regulates
shorthand: directly_positively_regulates

directly negatively regulates
database_cross_reference: RO:0002630
has_obo_namespace: external
id: directly_negatively_regulates
shorthand: directly_negatively_regulates

produces
database_cross_reference: RO:0003000
has_obo_namespace: external
id: produces
shorthand: produces

produced by
database_cross_reference: RO:0003001
has_obo_namespace: external
id: produced_by
shorthand: produced_by

has primary input or output
database_cross_reference: RO:0004007
has_obo_namespace: external
id: has_primary_input_or_output
shorthand: has_primary_input_or_output

has primary output
database_cross_reference: RO:0004008
has_obo_namespace: external
id: has_primary_output
shorthand: has_primary_output

has primary input
database_cross_reference: RO:0004009
has_obo_namespace: external
id: has_primary_input
shorthand: has_primary_input

has small molecule activator
database_cross_reference: RO:0012001
has_obo_namespace: external
id: has_small_molecule_activator
shorthand: has_small_molecule_activator

acts on population of
database_cross_reference: RO:0012003
has_obo_namespace: external
id: acts_on_population_of
shorthand: acts_on_population_of

results in fusion of
database_cross_reference: RO:0012008
has_obo_namespace: external
id: results_in_fusion_of
shorthand: results_in_fusion_of

regulates characteristic
database_cross_reference: RO:0019000
has_obo_namespace: gene_ontology
id: regulates_characteristic
shorthand: regulates_characteristic

positively regulates characteristic
database_cross_reference: RO:0019001
has_obo_namespace: gene_ontology
id: positively_regulates_characteristic
shorthand: positively_regulates_characteristic

negatively regulates characteristic
database_cross_reference: RO:0019002
has_obo_namespace: gene_ontology
id: negatively_regulates_characteristic
shorthand: negatively_regulates_characteristic

results in changes to anatomical or cellular structure
database_cross_reference: RO:0040036
has_obo_namespace: external
id: results_in_changes_to_anatomical_or_cellular_structure
shorthand: results_in_changes_to_anatomical_or_cellular_structure