---
layout: rule
id: GORULE:0000007
title: "IPI should not be used with GO:0003824 catalytic activity or descendents"
type: report
contact: "go-quality@lists.stanford.edu"
status: implemented
fail_mode: soft
implementations:
  - language: sparql
    code: |-
      PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
      PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
      PREFIX owl: <http://www.w3.org/2002/07/owl#>
      PREFIX RO: <http://purl.obolibrary.org/obo/RO_>
      PREFIX hasEvidence: <http://purl.obolibrary.org/obo/RO_0002612>
      PREFIX ECO: <http://purl.obolibrary.org/obo/ECO_>
      PREFIX GO: <http://purl.obolibrary.org/obo/GO_>
      PREFIX catalytic_activity: <http://purl.obolibrary.org/obo/GO_0003824>
      PREFIX IPI: <http://purl.obolibrary.org/obo/ECO_0000353>
      PREFIX metago: <http://model.geneontology.org/>

      SELECT ?subj ?relation ?object ?s ?evidence
      WHERE {
        GRAPH ?g {
            ?g metago:graphType metago:gafCam .

            ?s hasEvidence: ?evidence .
            ?evidence a IPI: .

            ?s owl:annotatedSource ?subj .
            ?s owl:annotatedProperty ?relation .
            ?s owl:annotatedTarget ?object .

            ?subj ?relation ?object .

            ?subj a ?iclass .
            ?object a catalytic_activity: .

            FILTER (?iclass != owl:NamedIndividual)

            # There should be no results where instances of
            # 'catalytic_activity molecular function' ; GO:0003824 also have evidences of IPI
        }
      }
      LIMIT 100

---
Evidence from a binary interaction ([IPI - Inferred from Physical Interaction evidence
code](http://www.geneontology.org/GO.evidence.shtml#ipi)) is considered too weak to support an annotation to catalytic activity ; GO:0003824 or children. 
These annotations are flagged and should be reviewed.