{ "summary": { "current": { "release_date": "2024-01-04", "valid_terms": 42454, "obsolete_terms": 5249, "merged_terms": 2441, "biological_process_terms": 27196, "molecular_function_terms": 11196, "cellular_component_terms": 4062, "meta_statements": 290095, "cross_references": 25592, "terms_relations": 85361 }, "previous": { "release_date": "2023-11-15", "valid_terms": 42769, "obsolete_terms": 4889, "merged_terms": 2441, "biological_process_terms": 27473, "molecular_function_terms": 11235, "cellular_component_terms": 4061, "meta_statements": 292132, "cross_references": 25492, "terms_relations": 86112 }, "changes": { "created_terms": 44, "valid_terms": -315, "obsolete_terms": 359, "merged_terms": 0, "biological_process_terms": -277, "molecular_function_terms": -39, "cellular_component_terms": 1, "meta_statements": 566, "meta_statements_by_term": 334, "cross_references": 610, "cross_references_by_term": 225, "relations": 724, "relations_by_term": 696 } }, "detailed_changes": { "created_terms": { "biological_process": [ { "id": "GO:0141115", "name": "symbiont-mediated suppression of host complement activation by inactivation of complement proteins" }, { "id": "GO:0141116", "name": "symbiont-mediated suppression of host complement activation by complement sequestering" }, { "id": "GO:0141117", "name": "symbiont-mediated suppression of host complement activation by recruitment of complement control protein" }, { "id": "GO:0141119", "name": "chromosomal DNA methylation maintenance following DNA replication" }, { "id": "GO:0141123", "name": "dermonecrosis in another organism" }, { "id": "GO:0141124", "name": "intracellular signaling cassette" }, { "id": "GO:0141127", "name": "symbiont-mediated perturbation of host Rab signal transduction" }, { "id": "GO:0141128", "name": "symbiont-mediated non-specific activation of host T-cells" }, { "id": "GO:0141129", "name": "symbiont-mediated suppression of host signal transduction pathway via antagonism of host cell surface receptor" }, { "id": "GO:0141130", "name": "symbiont-mediated inactivation of host ribosome" }, { "id": "GO:0141132", "name": "defense response to host" }, { "id": "GO:0141134", "name": "symbiont-mediated activation of host signal transduction pathway via agonism of host cell surface receptor" }, { "id": "GO:0141135", "name": "symbiont-mediated suppression of host chemokine signal transduction pathway" }, { "id": "GO:0141137", "name": "positive regulation of gene expression, epigenetic" }, { "id": "GO:0160127", "name": "protein-RNA covalent cross-linking repair" }, { "id": "GO:0160131", "name": "sperm migration through the uterotubal junction" }, { "id": "GO:0160135", "name": "phospholipase C-activating endothelin receptor signaling pathway" }, { "id": "GO:0170033", "name": "L-amino acid metabolic process" }, { "id": "GO:0170034", "name": "L-amino acid biosynthetic process" }, { "id": "GO:0170035", "name": "L-amino acid catabolic process" }, { "id": "GO:0170036", "name": "import into the mitochondrion" }, { "id": "GO:0170037", "name": "export from the mitochondrion" }, { "id": "GO:0170038", "name": "proteinogenic amino acid biosynthetic process" }, { "id": "GO:0170039", "name": "proteinogenic amino acid metabolic process" }, { "id": "GO:0170040", "name": "proteinogenic amino acid catabolic process" }, { "id": "GO:0170041", "name": "non-proteinogenic amino acid metabolic process" }, { "id": "GO:0170043", "name": "non-proteinogenic amino acid biosynthetic process" }, { "id": "GO:0170044", "name": "non-proteinogenic amino acid catabolic process" }, { "id": "GO:0180027", "name": "inner nuclear membrane-associated protein degradation pathway" }, { "id": "GO:0180029", "name": "phosphate ion export across plasma membrane" } ], "molecular_function": [ { "id": "GO:0141118", "name": "nitric oxide dioxygenase activity, heme protein as donor" }, { "id": "GO:0141122", "name": "nitrogen-oxygen hydrolyase activity" }, { "id": "GO:0141125", "name": "tRNA-queuosine(34) galactosyltransferase activity" }, { "id": "GO:0141126", "name": "short-chain fatty acyl-CoA hydrolase activity" }, { "id": "GO:0141131", "name": "DNA N6-methyladenine demethylase activity" }, { "id": "GO:0141133", "name": "diphthine methyl ester synthase activity" }, { "id": "GO:0160125", "name": "pH-gated sodium channel activity" }, { "id": "GO:0160126", "name": "pH-gated calcium channel activity" }, { "id": "GO:0160128", "name": "pH-gated monoatomic ion channel activity" }, { "id": "GO:0160129", "name": "protein-DNA covalent cross-linking activity" }, { "id": "GO:0160133", "name": "bicarbonate channel activity" }, { "id": "GO:0160134", "name": "protein-RNA sequence-specific adaptor activity" } ], "cellular_component": [ { "id": "GO:0160132", "name": "meisosome" }, { "id": "GO:0180028", "name": "mitotic spindle pole body attachment site" } ] }, "obsolete_terms": { "biological_process": [ { "id": "GO:0000412", "name": "histone peptidyl-prolyl isomerization" }, { "id": "GO:0002195", "name": "2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis" }, { "id": "GO:0006407", "name": "rRNA export from nucleus" }, { "id": "GO:0007227", "name": "signal transduction downstream of smoothened" }, { "id": "GO:0007228", "name": "positive regulation of hh target transcription factor activity" }, { "id": "GO:0007303", "name": "cytoplasmic transport, nurse cell to oocyte" }, { "id": "GO:0009444", "name": "pyruvate oxidation" }, { "id": "GO:0010390", "name": "histone monoubiquitination" }, { "id": "GO:0010452", "name": "histone H3-K36 methylation" }, { "id": "GO:0016570", "name": "histone modification" }, { "id": "GO:0016571", "name": "histone methylation" }, { "id": "GO:0016573", "name": "histone acetylation" }, { "id": "GO:0016574", "name": "histone ubiquitination" }, { "id": "GO:0016575", "name": "histone deacetylation" }, { "id": "GO:0016577", "name": "histone demethylation" }, { "id": "GO:0016578", "name": "histone deubiquitination" }, { "id": "GO:0018069", "name": "peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone" }, { "id": "GO:0018081", "name": "peptide cross-linking via lanthionine or 3-methyl-lanthionine" }, { "id": "GO:0018096", "name": "peptide cross-linking via S-(2-aminovinyl)-D-cysteine" }, { "id": "GO:0018124", "name": "peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone" }, { "id": "GO:0018132", "name": "peptide cross-linking via L-cysteine oxazolecarboxylic acid" }, { "id": "GO:0018133", "name": "peptide cross-linking via L-cysteine oxazolinecarboxylic acid" }, { "id": "GO:0018134", "name": "peptide cross-linking via glycine oxazolecarboxylic acid" }, { "id": "GO:0018137", "name": "peptide cross-linking via glycine thiazolecarboxylic acid" }, { "id": "GO:0018138", "name": "peptide cross-linking via L-serine thiazolecarboxylic acid" }, { "id": "GO:0018139", "name": "peptide cross-linking via L-phenylalanine thiazolecarboxylic acid" }, { "id": "GO:0018140", "name": "peptide cross-linking via L-cysteine thiazolecarboxylic acid" }, { "id": "GO:0018141", "name": "peptide cross-linking via L-lysine thiazolecarboxylic acid" }, { "id": "GO:0018142", "name": "protein-DNA covalent cross-linking" }, { "id": "GO:0018145", "name": "protein-DNA covalent cross-linking via peptidyl-serine" }, { "id": "GO:0018150", "name": "peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine" }, { "id": "GO:0018151", "name": "peptide cross-linking via L-histidyl-L-tyrosine" }, { "id": "GO:0018152", "name": "peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine" }, { "id": "GO:0018154", "name": "peptide cross-linking via (2R,6R)-lanthionine" }, { "id": "GO:0018155", "name": "peptide cross-linking via sn-(2S,6R)-lanthionine" }, { "id": "GO:0018156", "name": "peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine" }, { "id": "GO:0018157", "name": "peptide cross-linking via an oxazole or thiazole" }, { "id": "GO:0018162", "name": "peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine" }, { "id": "GO:0018163", "name": "protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine" }, { "id": "GO:0018164", "name": "protein-DNA covalent cross-linking via peptidyl-threonine" }, { "id": "GO:0018232", "name": "peptide cross-linking via S-(L-isoglutamyl)-L-cysteine" }, { "id": "GO:0018233", "name": "peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine" }, { "id": "GO:0018234", "name": "peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine" }, { "id": "GO:0018253", "name": "peptide cross-linking via 5-imidazolinone glycine" }, { "id": "GO:0018274", "name": "peptide cross-linking via L-lysinoalanine" }, { "id": "GO:0018313", "name": "peptide cross-linking via L-alanyl-5-imidazolinone glycine" }, { "id": "GO:0018908", "name": "organosulfide cycle" }, { "id": "GO:0019055", "name": "perturbation by virus of host cell cycle regulation" }, { "id": "GO:0019419", "name": "sulfate reduction" }, { "id": "GO:0019424", "name": "sulfide oxidation, using siroheme sulfite reductase" }, { "id": "GO:0019426", "name": "bisulfite reduction" }, { "id": "GO:0019800", "name": "peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan" }, { "id": "GO:0019926", "name": "peptidyl-tryptophan oxidation to tryptophyl quinone" }, { "id": "GO:0019927", "name": "peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone" }, { "id": "GO:0019928", "name": "peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid" }, { "id": "GO:0019929", "name": "peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid" }, { "id": "GO:0019932", "name": "second-messenger-mediated signaling" }, { "id": "GO:0021808", "name": "cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration" }, { "id": "GO:0021880", "name": "Notch signaling pathway involved in forebrain neuron fate commitment" }, { "id": "GO:0030433", "name": "ubiquitin-dependent ERAD pathway" }, { "id": "GO:0030959", "name": "peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine" }, { "id": "GO:0030960", "name": "peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine" }, { "id": "GO:0031056", "name": "regulation of histone modification" }, { "id": "GO:0031060", "name": "regulation of histone methylation" }, { "id": "GO:0031061", "name": "negative regulation of histone methylation" }, { "id": "GO:0031062", "name": "positive regulation of histone methylation" }, { "id": "GO:0031063", "name": "regulation of histone deacetylation" }, { "id": "GO:0031064", "name": "negative regulation of histone deacetylation" }, { "id": "GO:0031065", "name": "positive regulation of histone deacetylation" }, { "id": "GO:0032015", "name": "regulation of Ran protein signal transduction" }, { "id": "GO:0032016", "name": "negative regulation of Ran protein signal transduction" }, { "id": "GO:0032017", "name": "positive regulation of Ran protein signal transduction" }, { "id": "GO:0033169", "name": "histone H3-K9 demethylation" }, { "id": "GO:0033182", "name": "regulation of histone ubiquitination" }, { "id": "GO:0033183", "name": "negative regulation of histone ubiquitination" }, { "id": "GO:0033184", "name": "positive regulation of histone ubiquitination" }, { "id": "GO:0033522", "name": "histone H2A ubiquitination" }, { "id": "GO:0033523", "name": "histone H2B ubiquitination" }, { "id": "GO:0034720", "name": "histone H3-K4 demethylation" }, { "id": "GO:0034721", "name": "histone H3-K4 demethylation, trimethyl-H3-K4-specific" }, { "id": "GO:0034729", "name": "histone H3-K79 methylation" }, { "id": "GO:0034770", "name": "histone H4-K20 methylation" }, { "id": "GO:0034772", "name": "histone H4-K20 dimethylation" }, { "id": "GO:0034773", "name": "histone H4-K20 trimethylation" }, { "id": "GO:0034968", "name": "histone lysine methylation" }, { "id": "GO:0034969", "name": "histone arginine methylation" }, { "id": "GO:0034970", "name": "histone H3-R2 methylation" }, { "id": "GO:0034971", "name": "histone H3-R17 methylation" }, { "id": "GO:0034972", "name": "histone H3-R26 methylation" }, { "id": "GO:0035065", "name": "regulation of histone acetylation" }, { "id": "GO:0035066", "name": "positive regulation of histone acetylation" }, { "id": "GO:0035067", "name": "negative regulation of histone acetylation" }, { "id": "GO:0035518", "name": "histone H2A monoubiquitination" }, { "id": "GO:0035521", "name": "monoubiquitinated histone deubiquitination" }, { "id": "GO:0035522", "name": "monoubiquitinated histone H2A deubiquitination" }, { "id": "GO:0035616", "name": "histone H2B conserved C-terminal lysine deubiquitination" }, { "id": "GO:0035975", "name": "carbamoyl phosphate catabolic process" }, { "id": "GO:0035998", "name": "7,8-dihydroneopterin 3'-triphosphate biosynthetic process" }, { "id": "GO:0036123", "name": "histone H3-K9 dimethylation" }, { "id": "GO:0036124", "name": "histone H3-K9 trimethylation" }, { "id": "GO:0036210", "name": "protein modification process in another organism" }, { "id": "GO:0036351", "name": "histone H2A-K13 ubiquitination" }, { "id": "GO:0036352", "name": "histone H2A-K15 ubiquitination" }, { "id": "GO:0036353", "name": "histone H2A-K119 monoubiquitination" }, { "id": "GO:0038008", "name": "TRAF-mediated signal transduction" }, { "id": "GO:0039506", "name": "modulation by virus of host molecular function" }, { "id": "GO:0039507", "name": "suppression by virus of host molecular function" }, { "id": "GO:0039513", "name": "suppression by virus of host catalytic activity" }, { "id": "GO:0039516", "name": "modulation by virus of host catalytic activity" }, { "id": "GO:0039573", "name": "suppression by virus of host complement activation" }, { "id": "GO:0039644", "name": "suppression by virus of host NF-kappaB cascade" }, { "id": "GO:0039652", "name": "induction by virus of host NF-kappaB cascade" }, { "id": "GO:0039667", "name": "viral entry into host cell via pilus retraction" }, { "id": "GO:0039668", "name": "viral entry into host cell via pilus basal pore" }, { "id": "GO:0039669", "name": "viral entry into host cell via pilus retraction and membrane fusion" }, { "id": "GO:0039707", "name": "virus-mediated pore formation in host cell membrane" }, { "id": "GO:0042785", "name": "evasion of host immune response via modulation of host cytokine network" }, { "id": "GO:0043966", "name": "histone H3 acetylation" }, { "id": "GO:0043967", "name": "histone H4 acetylation" }, { "id": "GO:0043968", "name": "histone H2A acetylation" }, { "id": "GO:0043969", "name": "histone H2B acetylation" }, { "id": "GO:0043970", "name": "histone H3-K9 acetylation" }, { "id": "GO:0043971", "name": "histone H3-K18 acetylation" }, { "id": "GO:0043972", "name": "histone H3-K23 acetylation" }, { "id": "GO:0043973", "name": "histone H3-K4 acetylation" }, { "id": "GO:0043974", "name": "histone H3-K27 acetylation" }, { "id": "GO:0043977", "name": "histone H2A-K5 acetylation" }, { "id": "GO:0043979", "name": "histone H2B-K5 acetylation" }, { "id": "GO:0043980", "name": "histone H2B-K12 acetylation" }, { "id": "GO:0043981", "name": "histone H4-K5 acetylation" }, { "id": "GO:0043982", "name": "histone H4-K8 acetylation" }, { "id": "GO:0043983", "name": "histone H4-K12 acetylation" }, { "id": "GO:0043984", "name": "histone H4-K16 acetylation" }, { "id": "GO:0043985", "name": "histone H4-R3 methylation" }, { "id": "GO:0044000", "name": "movement in host" }, { "id": "GO:0044032", "name": "modulation by symbiont of indole acetic acid levels in host" }, { "id": "GO:0044072", "name": "suppression of host cell cycle progression" }, { "id": "GO:0044154", "name": "histone H3-K14 acetylation" }, { "id": "GO:0044534", "name": "envenomation resulting in modulation of apoptotic process in another organism" }, { "id": "GO:0044627", "name": "modulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044628", "name": "positive regulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044629", "name": "negative regulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044630", "name": "modulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044631", "name": "positive regulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044632", "name": "negative regulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044633", "name": "modulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044634", "name": "negative regulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044635", "name": "positive regulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044636", "name": "envenomation resulting in modulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044637", "name": "envenomation resulting in negative regulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044638", "name": "envenomation resulting in positive regulation of complement activation, classical pathway in another organism" }, { "id": "GO:0044639", "name": "envenomation resulting in modulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044640", "name": "envenomation resulting in negative regulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044641", "name": "envenomation resulting in positive regulation of complement activation, lectin pathway in another organism" }, { "id": "GO:0044642", "name": "envenomation resulting in modulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044643", "name": "envenomation resulting in positive regulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044644", "name": "envenomation resulting in negative regulation of complement activation, alternative pathway in another organism" }, { "id": "GO:0044645", "name": "modulation of complement activation in another organism" }, { "id": "GO:0044646", "name": "envenomation resulting in modulation of complement activation in another organism" }, { "id": "GO:0044648", "name": "histone H3-K4 dimethylation" }, { "id": "GO:0044832", "name": "induction by virus of host cytokine production" }, { "id": "GO:0044846", "name": "negative regulation by symbiont of indole acetic acid levels in host" }, { "id": "GO:0045326", "name": "protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine" }, { "id": "GO:0045327", "name": "protein-DNA covalent cross-linking via peptidyl-tyrosine" }, { "id": "GO:0046792", "name": "suppression by virus of host cell cycle arrest" }, { "id": "GO:0046804", "name": "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide" }, { "id": "GO:0048108", "name": "peptide cross-linking via 4-amino-3-isothiazolidinone" }, { "id": "GO:0048109", "name": "peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine" }, { "id": "GO:0050739", "name": "peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium" }, { "id": "GO:0050745", "name": "peptide cross-linking via L-cysteinyl-5-imidazolinone glycine" }, { "id": "GO:0050837", "name": "peptide cross-linking via L-cysteinyl-L-selenocysteine" }, { "id": "GO:0051567", "name": "histone H3-K9 methylation" }, { "id": "GO:0051568", "name": "histone H3-K4 methylation" }, { "id": "GO:0051569", "name": "regulation of histone H3-K4 methylation" }, { "id": "GO:0051570", "name": "regulation of histone H3-K9 methylation" }, { "id": "GO:0051571", "name": "positive regulation of histone H3-K4 methylation" }, { "id": "GO:0051572", "name": "negative regulation of histone H3-K4 methylation" }, { "id": "GO:0051573", "name": "negative regulation of histone H3-K9 methylation" }, { "id": "GO:0051574", "name": "positive regulation of histone H3-K9 methylation" }, { "id": "GO:0052019", "name": "modulation by symbiont of host hormone or growth regulator levels" }, { "id": "GO:0052021", "name": "modulation by symbiont of ethylene levels in host" }, { "id": "GO:0052022", "name": "modulation by symbiont of jasmonic acid levels in host" }, { "id": "GO:0052023", "name": "modulation by symbiont of salicylic acid levels in host" }, { "id": "GO:0052024", "name": "positive regulation by symbiont of hormone or growth regulator levels in host" }, { "id": "GO:0052053", "name": "negative regulation by symbiont of host catalytic activity" }, { "id": "GO:0052055", "name": "modulation by symbiont of host molecular function" }, { "id": "GO:0052062", "name": "induction by symbiont of host phytoalexin production" }, { "id": "GO:0052074", "name": "positive regulation by symbiont of host salicylic acid-mediated defense response" }, { "id": "GO:0052075", "name": "induction by symbiont of host jasmonic acid-mediated defense response" }, { "id": "GO:0052102", "name": "positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" }, { "id": "GO:0052104", "name": "induction by symbiont of host systemic acquired resistance" }, { "id": "GO:0052148", "name": "modulation by symbiont of host catalytic activity" }, { "id": "GO:0052344", "name": "positive regulation by symbiont of host phytoalexin production" }, { "id": "GO:0052390", "name": "induction by symbiont of host innate immune response" }, { "id": "GO:0052489", "name": "negative regulation by host of symbiont programmed cell death" }, { "id": "GO:0052559", "name": "induction by symbiont of host immune response" }, { "id": "GO:0060153", "name": "perturbation by virus of host cell cycle progression" }, { "id": "GO:0060823", "name": "canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation" }, { "id": "GO:0060827", "name": "regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation" }, { "id": "GO:0060829", "name": "negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation" }, { "id": "GO:0061085", "name": "regulation of histone H3-K27 methylation" }, { "id": "GO:0061086", "name": "negative regulation of histone H3-K27 methylation" }, { "id": "GO:0061087", "name": "positive regulation of histone H3-K27 methylation" }, { "id": "GO:0061290", "name": "canonical Wnt signaling pathway involved in metanephric kidney development" }, { "id": "GO:0061291", "name": "canonical Wnt signaling pathway involved in ureteric bud branching" }, { "id": "GO:0061293", "name": "canonical Wnt signaling pathway involved in mesonephric nephron development" }, { "id": "GO:0061359", "name": "regulation of Wnt signaling pathway by Wnt protein secretion" }, { "id": "GO:0061647", "name": "histone H3-K9 modification" }, { "id": "GO:0061765", "name": "perturbation by virus of host non-canonical NF-kappaB signal transduction" }, { "id": "GO:0070076", "name": "histone lysine demethylation" }, { "id": "GO:0070078", "name": "histone H3-R2 demethylation" }, { "id": "GO:0070079", "name": "histone H4-R3 demethylation" }, { "id": "GO:0070423", "name": "nucleotide-binding oligomerization domain containing signaling pathway" }, { "id": "GO:0070512", "name": "positive regulation of histone H4-K20 methylation" }, { "id": "GO:0070535", "name": "histone H2A K63-linked ubiquitination" }, { "id": "GO:0070537", "name": "histone H2A K63-linked deubiquitination" }, { "id": "GO:0070544", "name": "histone H3-K36 demethylation" }, { "id": "GO:0070734", "name": "histone H3-K27 methylation" }, { "id": "GO:0070932", "name": "histone H3 deacetylation" }, { "id": "GO:0070933", "name": "histone H4 deacetylation" }, { "id": "GO:0071557", "name": "histone H3-K27 demethylation" }, { "id": "GO:0071572", "name": "histone H3-K56 deacetylation" }, { "id": "GO:0071712", "name": "ER-associated misfolded protein catabolic process" }, { "id": "GO:0071847", "name": "TNFSF11-mediated signaling pathway" }, { "id": "GO:0071848", "name": "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling" }, { "id": "GO:0071894", "name": "histone H2B conserved C-terminal lysine ubiquitination" }, { "id": "GO:0075112", "name": "perturbation of host transmembrane receptor-mediated signal transduction" }, { "id": "GO:0075114", "name": "symbiont-mediated suppression of host transmembrane receptor-mediated signal transduction" }, { "id": "GO:0075343", "name": "modulation by symbiont of abscisic acid levels in host" }, { "id": "GO:0080182", "name": "histone H3-K4 trimethylation" }, { "id": "GO:0086024", "name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate" }, { "id": "GO:0086094", "name": "positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction" }, { "id": "GO:0086096", "name": "adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process" }, { "id": "GO:0086102", "name": "adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" }, { "id": "GO:0090226", "name": "regulation of microtubule nucleation by Ran protein signal transduction" }, { "id": "GO:0090239", "name": "regulation of histone H4 acetylation" }, { "id": "GO:0090240", "name": "positive regulation of histone H4 acetylation" }, { "id": "GO:0090241", "name": "negative regulation of histone H4 acetylation" }, { "id": "GO:0097043", "name": "histone H3-K56 acetylation" }, { "id": "GO:0097198", "name": "histone H3-K36 trimethylation" }, { "id": "GO:0097290", "name": "alpha-ribazole biosynthetic process" }, { "id": "GO:0097676", "name": "histone H3-K36 dimethylation" }, { "id": "GO:0097692", "name": "histone H3-K4 monomethylation" }, { "id": "GO:0098532", "name": "histone H3-K27 trimethylation" }, { "id": "GO:0140192", "name": "regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process" }, { "id": "GO:0140193", "name": "regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process" }, { "id": "GO:0140194", "name": "negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process" }, { "id": "GO:0140195", "name": "positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process" }, { "id": "GO:0140200", "name": "adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate" }, { "id": "GO:0140655", "name": "mitochondrial proliferation" }, { "id": "GO:0141075", "name": "symbiont-mediated suppression of host JAK-STAT cascade" }, { "id": "GO:0141076", "name": "symbiont-mediated suppression of host TRAF-mediated signal transduction" }, { "id": "GO:0141077", "name": "suppression of host interferon-mediated signaling pathway" }, { "id": "GO:0141105", "name": "symbiont-mediated suppression of host toll-like receptor signal transduction" }, { "id": "GO:1900109", "name": "regulation of histone H3-K9 dimethylation" }, { "id": "GO:1900110", "name": "negative regulation of histone H3-K9 dimethylation" }, { "id": "GO:1900111", "name": "positive regulation of histone H3-K9 dimethylation" }, { "id": "GO:1900112", "name": "regulation of histone H3-K9 trimethylation" }, { "id": "GO:1900113", "name": "negative regulation of histone H3-K9 trimethylation" }, { "id": "GO:1900114", "name": "positive regulation of histone H3-K9 trimethylation" }, { "id": "GO:1900992", "name": "(-)-secologanin metabolic process" }, { "id": "GO:1900993", "name": "(-)-secologanin catabolic process" }, { "id": "GO:1901007", "name": "(S)-scoulerine metabolic process" }, { "id": "GO:1901010", "name": "(S)-reticuline metabolic process" }, { "id": "GO:1901083", "name": "pyrrolizidine alkaloid metabolic process" }, { "id": "GO:1901101", "name": "gramicidin S metabolic process" }, { "id": "GO:1901102", "name": "gramicidin S catabolic process" }, { "id": "GO:1901314", "name": "regulation of histone H2A K63-linked ubiquitination" }, { "id": "GO:1901315", "name": "negative regulation of histone H2A K63-linked ubiquitination" }, { "id": "GO:1901316", "name": "positive regulation of histone H2A K63-linked ubiquitination" }, { "id": "GO:1901585", "name": "regulation of acid-sensing ion channel activity" }, { "id": "GO:1901586", "name": "negative regulation of acid-sensing ion channel activity" }, { "id": "GO:1901587", "name": "positive regulation of acid-sensing ion channel activity" }, { "id": "GO:1901725", "name": "regulation of histone deacetylase activity" }, { "id": "GO:1901726", "name": "negative regulation of histone deacetylase activity" }, { "id": "GO:1901727", "name": "positive regulation of histone deacetylase activity" }, { "id": "GO:1902464", "name": "regulation of histone H3-K27 trimethylation" }, { "id": "GO:1902465", "name": "negative regulation of histone H3-K27 trimethylation" }, { "id": "GO:1902466", "name": "positive regulation of histone H3-K27 trimethylation" }, { "id": "GO:1903069", "name": "regulation of ER-associated ubiquitin-dependent protein catabolic process" }, { "id": "GO:1903070", "name": "negative regulation of ER-associated ubiquitin-dependent protein catabolic process" }, { "id": "GO:1903071", "name": "positive regulation of ER-associated ubiquitin-dependent protein catabolic process" }, { "id": "GO:1903584", "name": "regulation of histone deubiquitination" }, { "id": "GO:1903585", "name": "negative regulation of histone deubiquitination" }, { "id": "GO:1903586", "name": "positive regulation of histone deubiquitination" }, { "id": "GO:1903649", "name": "regulation of cytoplasmic transport" }, { "id": "GO:1903650", "name": "negative regulation of cytoplasmic transport" }, { "id": "GO:1903651", "name": "positive regulation of cytoplasmic transport" }, { "id": "GO:1904379", "name": "protein localization to cytosolic proteasome complex involved in ERAD pathway" }, { "id": "GO:1905427", "name": "intracellular signal transduction involved in positive regulation of cell growth" }, { "id": "GO:1990210", "name": "positive regulation by symbiont of indole acetic acid levels in host" }, { "id": "GO:1990211", "name": "positive regulation by symbiont of jasmonic acid levels in host" }, { "id": "GO:1990212", "name": "positive regulation by symbiont of ethylene levels in host" }, { "id": "GO:1990213", "name": "negative regulation by symbiont of salicylic acid levels in host" }, { "id": "GO:1990218", "name": "positive regulation by symbiont of abscisic acid levels in host" }, { "id": "GO:1990223", "name": "positive regulation by symbiont of cytokinin levels in host" }, { "id": "GO:1990258", "name": "histone glutamine methylation" }, { "id": "GO:1990619", "name": "histone H3-K9 deacetylation" }, { "id": "GO:1990678", "name": "histone H4-K16 deacetylation" }, { "id": "GO:1990679", "name": "histone H4-K12 deacetylation" }, { "id": "GO:2000615", "name": "regulation of histone H3-K9 acetylation" }, { "id": "GO:2000616", "name": "negative regulation of histone H3-K9 acetylation" }, { "id": "GO:2000617", "name": "positive regulation of histone H3-K9 acetylation" }, { "id": "GO:2000620", "name": "positive regulation of histone H4-K16 acetylation" }, { "id": "GO:2001166", "name": "regulation of histone H2B ubiquitination" }, { "id": "GO:2001168", "name": "positive regulation of histone H2B ubiquitination" }, { "id": "GO:2001173", "name": "regulation of histone H2B conserved C-terminal lysine ubiquitination" } ], "molecular_function": [ { "id": "GO:0004395", "name": "hexaprenyldihydroxybenzoate methyltransferase activity" }, { "id": "GO:0008689", "name": "3-demethylubiquinone-9 3-O-methyltransferase activity" }, { "id": "GO:0016290", "name": "palmitoyl-CoA hydrolase activity" }, { "id": "GO:0018657", "name": "toluene 3-monooxygenase activity" }, { "id": "GO:0030580", "name": "quinone cofactor methyltransferase activity" }, { "id": "GO:0038058", "name": "TNFSF11 receptor activity" }, { "id": "GO:0043333", "name": "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" }, { "id": "GO:0043334", "name": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" }, { "id": "GO:0043428", "name": "2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" }, { "id": "GO:0043429", "name": "2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" }, { "id": "GO:0043430", "name": "2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" }, { "id": "GO:0043734", "name": "DNA-N1-methyladenine dioxygenase activity" }, { "id": "GO:0043820", "name": "propionyl-CoA dehydrogenase activity" }, { "id": "GO:0043826", "name": "sulfur oxygenase reductase activity" }, { "id": "GO:0043841", "name": "(S)-lactate 2-kinase activity" }, { "id": "GO:0044466", "name": "glutaryl-CoA hydrolase activity" }, { "id": "GO:0044595", "name": "decaprenyldihydroxybenzoate methyltransferase activity" }, { "id": "GO:0044596", "name": "3-demethylubiquinol-10 3-O-methyltransferase activity" }, { "id": "GO:0044736", "name": "acid-sensing ion channel activity" }, { "id": "GO:0047379", "name": "ADP-dependent short-chain-acyl-CoA hydrolase activity" }, { "id": "GO:0047380", "name": "ADP-dependent medium-chain-acyl-CoA hydrolase activity" }, { "id": "GO:0047409", "name": "alkenylglycerophosphoethanolamine hydrolase activity" }, { "id": "GO:0047410", "name": "N-formylmethionylaminoacyl-tRNA deformylase activity" }, { "id": "GO:0047702", "name": "beta-lysine 5,6-aminomutase activity" }, { "id": "GO:0047901", "name": "formyl-CoA hydrolase activity" }, { "id": "GO:0050245", "name": "quercitrinase activity" }, { "id": "GO:0050562", "name": "lysine-tRNA(Pyl) ligase activity" }, { "id": "GO:0052859", "name": "glucan endo-1,4-beta-glucosidase activity" }, { "id": "GO:0061543", "name": "3-demethylubiquinol-6 3-O-methyltransferase activity" }, { "id": "GO:0061810", "name": "NAD glycohydrolase activity" }, { "id": "GO:0061811", "name": "ADP-ribosyl cyclase activity" }, { "id": "GO:0061812", "name": "cyclic ADP-ribose hydrolase" }, { "id": "GO:0099119", "name": "3-demethylubiquinol-8 3-O-methyltransferase activity" }, { "id": "GO:0102030", "name": "dTDP-L-rhamnose synthetase activity" }, { "id": "GO:0102040", "name": "fumarate reductase (menaquinone)" }, { "id": "GO:0102053", "name": "(-)-jasmonoyl-isoleucine synthetase activity" }, { "id": "GO:0102057", "name": "jasmonoyl-valine synthetase activity" }, { "id": "GO:0102058", "name": "jasmonoyl-leucine synthetase activity" }, { "id": "GO:0102184", "name": "cycloartenol 4alpha-methyl oxidase activity" }, { "id": "GO:0102185", "name": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity" }, { "id": "GO:0102186", "name": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity" }, { "id": "GO:0102188", "name": "4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity" }, { "id": "GO:0102190", "name": "4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity" }, { "id": "GO:0102278", "name": "N,N'-diacetylchitobiose synthase activity" }, { "id": "GO:0102393", "name": "decanoyl-[acp] 2-dehydrogenase activity" }, { "id": "GO:0102783", "name": "beta-carotene oxygenase activity" }, { "id": "GO:0102991", "name": "myristoyl-CoA hydrolase activity" }, { "id": "GO:0106314", "name": "nitrite reductase NADPH activity" }, { "id": "GO:0140061", "name": "5-hydroxymethylcytosine dioxygenase activity" }, { "id": "GO:0140062", "name": "5-formylcytosine dioxygenase activity" }, { "id": "GO:1990887", "name": "2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity" } ], "cellular_component": [ { "id": "GO:0097344", "name": "Rix1 complex" } ] }, "merged_terms": {}, "meta_statements": { "biological_process": [ { "id": "GO:0000038", "name": "very long-chain fatty acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.\" [GOC:hjd]", "previous": "\"The chemical reactions and pathways involving a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons.\" [GOC:hjd]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0000196", "name": "cell wall integrity MAPK cascade", "changes": { "definition": { "current": "\"A MAPK cascade that contributes to cell wall organization or biogenesis.\" [PMID:15944456, PMID:17604854, PMID:26945038, PMID:9561267]", "previous": "\"A MAPK cascade that contributes to cell wall organization or biogenesis.\" [PMID:17604854, PMID:9561267]" } } }, { "id": "GO:0000910", "name": "cytokinesis", "changes": { "subsets": { "current": [ "gocheck_do_not_manually_annotate", "goslim_candida", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "gocheck_do_not_manually_annotate", "goslim_candida", "goslim_generic", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0001579", "name": "medium-chain fatty acid transport", "changes": { "definition": { "current": "\"The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [GOC:ai]", "previous": "\"The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0001676", "name": "long-chain fatty acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:ajp]", "previous": "\"The chemical reactions and pathways involving a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:ajp]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0005975", "name": "carbohydrate metabolic process", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006091", "name": "generation of precursor metabolites and energy", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006260", "name": "DNA replication", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006281", "name": "DNA repair", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006310", "name": "DNA recombination", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006351", "name": "DNA-templated transcription", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0006355", "name": "regulation of DNA-templated transcription", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0006412", "name": "translation", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_metagenomics", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0006457", "name": "protein folding", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006486", "name": "protein glycosylation", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_generic", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006520", "name": "amino acid metabolic process", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006575", "name": "cellular modified amino acid metabolic process", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0006629", "name": "lipid metabolic process", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0006790", "name": "sulfur compound metabolic process", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0006810", "name": "transport", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_candida", "goslim_chembl", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_annotate", "goslim_candida", "goslim_chembl", "goslim_metagenomics", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0006886", "name": "intracellular protein transport", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0007005", "name": "mitochondrion organization", "changes": { "synonyms": { "current": [ "\"mitochondria organization\" EXACT [GOC:mah]", "\"mitochondrial biogenesis\" EXACT []", "\"mitochondrial organization\" EXACT []", "\"mitochondrion biogenesis\" EXACT []", "\"mitochondrion organisation\" EXACT [GOC:mah]", "\"mitochondrion organization and biogenesis\" RELATED []" ], "previous": [ "\"mitochondria organization\" EXACT [GOC:mah]", "\"mitochondrion organisation\" EXACT [GOC:mah]", "\"mitochondrion organization and biogenesis\" RELATED []" ] } } }, { "id": "GO:0007010", "name": "cytoskeleton organization", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0007059", "name": "chromosome segregation", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0007155", "name": "cell adhesion", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0007163", "name": "establishment or maintenance of cell polarity", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0007224", "name": "smoothened signaling pathway", "changes": { "definition": { "current": "\"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.\" [GOC:mah, PMID:15057936, PMID:15205520]", "previous": "\"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.\" [GOC:mah, PMID:15205520]" } } }, { "id": "GO:0007249", "name": "canonical NF-kappaB signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).\" [GOC:bf, PMID:12773372, PMID:34659217]", "previous": "\"The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).\" [GOC:bf, PMID:12773372, PMID:34659217]" }, "synonyms": { "current": [ "\"canonical NF-kappaB signaling cascade\" EXACT [GOC:bf]", "\"I-kappaB kinase/NF-kappaB cascade\" EXACT [GOC:signaling]", "\"I-kappaB kinase/NF-kappaB signal transduction\" EXACT [GOC:signaling]", "\"I-kappaB kinase/NF-kappaB signaling\" EXACT []", "\"NF-kappaB cascade\" BROAD []", "\"p50-dependent NF-kappaB signaling\" RELATED [PMID:18292232]" ], "previous": [ "\"canonical NF-kappaB signaling cascade\" EXACT [GOC:bf]", "\"I-kappaB kinase/NF-kappaB cascade\" EXACT [GOC:signaling]", "\"I-kappaB kinase/NF-kappaB signal transduction\" EXACT [GOC:signaling]", "\"I-kappaB kinase/NF-kappaB signaling\" EXACT []", "\"NF-kappaB cascade\" EXACT []", "\"p50-dependent NF-kappaB signaling\" RELATED [PMID:18292232]" ] } } }, { "id": "GO:0007263", "name": "nitric oxide mediated signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.\" [GOC:jl, PMID:21549190]", "previous": "\"Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.\" [GOC:jl, PMID:21549190]" } } }, { "id": "GO:0007264", "name": "small GTPase-mediated signal transduction", "changes": { "name": { "current": "small GTPase-mediated signal transduction", "previous": "small GTPase mediated signal transduction" }, "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals in which a small monomeric GTPase relays a signal.\" [GOC:mah]" }, "synonyms": { "current": [ "\"Ras family protein signal transduction\" NARROW []", "\"small GTPase mediated signal transduction\" EXACT []" ], "previous": [ "\"small GTPase-mediated signal transduction\" EXACT []" ] } } }, { "id": "GO:0007265", "name": "Ras protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal.\" [GOC:bf]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.\" [GOC:bf]" } } }, { "id": "GO:0007266", "name": "Rho protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal.\" [GOC:bf]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.\" [GOC:bf]" } } }, { "id": "GO:0009627", "name": "systemic acquired resistance", "changes": { "definition": { "current": "\"The salicylic acid-mediated response to a pathogen which confers broad spectrum resistance.\" [GOC:lr, Wikipedia:Systemic_acquired_resistance]", "previous": "\"The salicylic acid mediated response to a pathogen which confers broad spectrum resistance.\" [GOC:lr, ISBN:0521436125]" } } }, { "id": "GO:0009682", "name": "induced systemic resistance", "changes": { "definition": { "current": "\"A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling.\" [PMID:10234273, PMID:15233292, PMID:23386685]", "previous": "\"A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling.\" [PMID:10234273]" } } }, { "id": "GO:0009695", "name": "jasmonic acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.\" [PMID:33821356]", "previous": "\"The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.\" [ISBN:0387969845]" } } }, { "id": "GO:0010746", "name": "regulation of long-chain fatty acid import across plasma membrane", "changes": { "definition": { "current": "\"Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:BHF, GOC:dph, GOC:tb]", "previous": "\"Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.\" [GOC:BHF, GOC:dph, GOC:tb]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0010747", "name": "positive regulation of long-chain fatty acid import across plasma membrane", "changes": { "definition": { "current": "\"Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:BHF, GOC:dph, GOC:tb]", "previous": "\"Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.\" [GOC:BHF, GOC:dph, GOC:tb]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0012501", "name": "programmed cell death", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_agr", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_mouse", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0015909", "name": "long-chain fatty acid transport", "changes": { "definition": { "current": "\"The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:ai]", "previous": "\"The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015910", "name": "long-chain fatty acid import into peroxisome", "changes": { "definition": { "current": "\"The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:ai]", "previous": "\"The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015911", "name": "long-chain fatty acid import across plasma membrane", "changes": { "definition": { "current": "\"The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:ai]", "previous": "\"The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015912", "name": "short-chain fatty acid transport", "changes": { "definition": { "current": "\"The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [GOC:ai]", "previous": "\"The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015913", "name": "short-chain fatty acid transmembrane transport", "changes": { "definition": { "current": "\"The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [GOC:ai]", "previous": "\"The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons.\" [GOC:ai]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015979", "name": "photosynthesis", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0016070", "name": "RNA metabolic process", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_metagenomics", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_metagenomics", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0016071", "name": "mRNA metabolic process", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0016601", "name": "Rac protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal.\" [GOC:bf]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.\" [GOC:bf]" } } }, { "id": "GO:0019042", "name": "viral latency", "changes": { "definition": { "current": "\"The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate.\" [GOC:jl, VZ:3970]", "previous": "\"The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate.\" [GOC:jl]" } } }, { "id": "GO:0019069", "name": "viral capsid assembly", "changes": { "definition": { "current": "\"The assembly of a virus capsid from its protein subunits.\" [ISBN:0781702534, PMID:22615368]", "previous": "\"The assembly of a virus capsid from its protein subunits.\" [ISBN:0781702534, UniProtKB-KW:KW-0118]" } } }, { "id": "GO:0019418", "name": "sulfide oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.\" [MetaCyc:P222-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]", "previous": "\"The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.\" [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]" } } }, { "id": "GO:0019420", "name": "dissimilatory sulfate reduction", "changes": { "definition": { "current": "\"The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide.\" [PMID:25400653, PMID:26680199]", "previous": "\"The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide.\" [GOC:jl, MetaCyc:DISSULFRED-PWY]" } } }, { "id": "GO:0019626", "name": "short-chain fatty acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [ISBN:0198506732]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of less than 6 carbons.\" [ISBN:0198506732]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0019933", "name": "cAMP-mediated signaling", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]", "previous": "\"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]" } } }, { "id": "GO:0019934", "name": "cGMP-mediated signaling", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]", "previous": "\"Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]" } } }, { "id": "GO:0019935", "name": "cyclic-nucleotide-mediated signaling", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with production or release of the cyclic nucleotide, and ends with the activation of downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]", "previous": "\"Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.\" [GOC:signaling]" } } }, { "id": "GO:0023052", "name": "signaling", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0030030", "name": "cell projection organization", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0030163", "name": "protein catabolic process", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_drosophila", "goslim_generic", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0030643", "name": "intracellular phosphate ion homeostasis", "changes": { "synonyms": { "current": [ "\"cellular phosphate ion homeostasis\" EXACT []", "\"intracellular phosphate homeostasis\" BROAD []", "\"intracellular Pi homeostasis\" EXACT []" ], "previous": [ "\"cellular phosphate ion homeostasis\" EXACT []" ] } } }, { "id": "GO:0030682", "name": "symbiont-mediated perturbation of host defenses", "changes": { "name": { "current": "symbiont-mediated perturbation of host defenses", "previous": "perturbation of host defenses by symbiont" }, "definition": { "current": "\"A process in which a symbiont alters or subverts the normal execution of a host organism's defense response. The host defense response is mounted by the host in response to the presence of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]", "previous": "\"A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"avoidance of defenses of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"avoidance of defenses of other organism involved in symbiotic interaction\" NARROW []", "\"avoidance of host defences\" NARROW []", "\"avoidance of host defenses\" NARROW []", "\"evasion of host defence response\" NARROW []", "\"evasion of other organism defence response\" NARROW []", "\"evasion or tolerance of defense response of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"evasion or tolerance of defense response of other organism involved in symbiotic interaction\" BROAD []", "\"evasion or tolerance of defenses of other organism\" RELATED []", "\"evasion or tolerance of defenses of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"evasion or tolerance of defenses of other organism involved in symbiotic interaction\" RELATED []", "\"evasion or tolerance of host defense response\" NARROW []", "\"evasion or tolerance of host defenses\" RELATED []", "\"mitigation of host defenses by symbiont\" EXACT []", "\"perturbation of host defenses by symbiont\" EXACT []" ], "previous": [ "\"avoidance of defenses of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"avoidance of defenses of other organism involved in symbiotic interaction\" NARROW []", "\"avoidance of host defences\" NARROW []", "\"avoidance of host defenses\" NARROW []", "\"evasion of host defence response\" NARROW []", "\"evasion of other organism defence response\" NARROW []", "\"evasion or tolerance of defense response of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"evasion or tolerance of defense response of other organism involved in symbiotic interaction\" BROAD []", "\"evasion or tolerance of defenses of other organism\" RELATED []", "\"evasion or tolerance of defenses of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"evasion or tolerance of defenses of other organism involved in symbiotic interaction\" RELATED []", "\"evasion or tolerance of host defense response\" NARROW []", "\"evasion or tolerance of host defenses\" RELATED []", "\"mitigation of host defenses by symbiont\" EXACT []" ] } } }, { "id": "GO:0030968", "name": "endoplasmic reticulum unfolded protein response", "changes": { "comment": { "current": "Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.", "previous": "Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'." } } }, { "id": "GO:0031291", "name": "Ran protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Ran subfamily relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.\" [GOC:mah]" } } }, { "id": "GO:0032011", "name": "ARF protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the ARF subfamily relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state.\" [GOC:mah]" } } }, { "id": "GO:0032359", "name": "provirus excision", "changes": { "definition": { "current": "\"The molecular events that lead to the excision of a viral genome from the host genome.\" [GOC:mlg, VZ:3969]", "previous": "\"The molecular events that lead to the excision of a viral genome from the host genome.\" [GOC:mlg]" } } }, { "id": "GO:0032482", "name": "Rab protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.\" [GOC:mah]" } } }, { "id": "GO:0032484", "name": "Ral protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the RaI subfamily relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.\" [GOC:mah]" } } }, { "id": "GO:0032486", "name": "Rap protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal.\" [GOC:mah]", "previous": "\"The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.\" [GOC:mah]" } } }, { "id": "GO:0032488", "name": "Cdc42 protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal.\" [GOC:mah, PMID:18558478]", "previous": "\"The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.\" [GOC:mah, PMID:18558478]" } } }, { "id": "GO:0033013", "name": "tetrapyrrole metabolic process", "changes": { "subsets": { "current": [ "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0034050", "name": "symbiont-induced defense-related programmed cell death", "changes": { "name": { "current": "symbiont-induced defense-related programmed cell death", "previous": "programmed cell death induced by symbiont" }, "comment": { "current": "Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'.", "previous": "Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'positive regulation by symbiont of host programmed cell death ; GO:0052042'." }, "synonyms": { "current": [ "\"host programmed cell death induced by symbiont\" EXACT []", "\"programmed cell death induced by symbiont\" EXACT []" ], "previous": [ "\"'host programmed cell death induced by symbiont'\" EXACT []" ] } } }, { "id": "GO:0034080", "name": "CENP-A containing chromatin assembly", "changes": { "definition": { "current": "\"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.\" [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]", "previous": "\"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.\" [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403]" } } }, { "id": "GO:0035329", "name": "hippo signaling", "changes": { "definition": { "current": "\"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.\" [PMID:17318211, PMID:18328423, PMID:36347846]", "previous": "\"The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.\" [PMID:17318211, PMID:18328423]" } } }, { "id": "GO:0035336", "name": "long-chain fatty-acyl-CoA metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [ISBN:0198506732]", "previous": "\"The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.\" [ISBN:0198506732]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0035338", "name": "long-chain fatty-acyl-CoA biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [ISBN:0198506732]", "previous": "\"The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.\" [ISBN:0198506732]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0035556", "name": "intracellular signal transduction", "changes": { "synonyms": { "current": [ "\"intracellular signal transduction pathway\" NARROW []", "\"intracellular signaling cascade\" RELATED [GOC:signaling]", "\"intracellular signaling pathway\" RELATED []", "\"signal transmission via intracellular cascade\" NARROW []" ], "previous": [ "\"intracellular protein kinase cascade\" NARROW [GOC:signaling]", "\"intracellular signal transduction pathway\" NARROW []", "\"intracellular signaling cascade\" RELATED [GOC:signaling]", "\"intracellular signaling chain\" EXACT [ISBN:3527303782]", "\"intracellular signaling pathway\" RELATED []", "\"protein kinase cascade\" NARROW [GOC:signaling]", "\"signal transduction via intracellular signaling cascade\" RELATED []", "\"signal transmission via intracellular cascade\" NARROW []" ] } } }, { "id": "GO:0036111", "name": "very long-chain fatty-acyl-CoA metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.\" [GOC:pm]", "previous": "\"The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.\" [GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036112", "name": "medium-chain fatty-acyl-CoA metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [GOC:pm]", "previous": "\"The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036113", "name": "very long-chain fatty-acyl-CoA catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.\" [GOC:pm]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.\" [GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036114", "name": "medium-chain fatty-acyl-CoA catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [GOC:pm]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036116", "name": "long-chain fatty-acyl-CoA catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:pm]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.\" [GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036211", "name": "protein modification process", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0036386", "name": "bacterial nucleoid packaging", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0038060", "name": "nitric oxide-cGMP-mediated signaling pathway", "changes": { "definition": { "current": "\"An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.\" [GOC:signaling, PMID:21549190, PMID:22019632]", "previous": "\"Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.\" [GOC:signaling, PMID:21549190, PMID:22019632]" } } }, { "id": "GO:0038061", "name": "non-canonical NF-kappaB signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).\" [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]", "previous": "\"The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).\" [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217]" }, "synonyms": { "current": [ "\"NF-kappaB cascade\" BROAD []", "\"NIK-IKK kinase cascade\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK-IKK signaling pathway\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK-IKK-alpha cascade\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK/NF-kappaB cascade\" EXACT [GOC:signaling]", "\"NIK/NF-kappaB signal transduction\" EXACT [GOC:signaling]", "\"NIK/NF-kappaB signaling\" EXACT []", "\"non-canonical NF-KB signaling\" EXACT [PMID:21173796]", "\"noncanonical NF-kappaB signaling\" EXACT [PMID:20501935]", "\"noncanonical nuclear factor kappaB (NF-kappaB) pathway\" EXACT [PMID:20501935]", "\"p52-dependent NF-kappaB signaling\" NARROW [PMID:18292232]" ], "previous": [ "\"NIK-IKK kinase cascade\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK-IKK signaling pathway\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK-IKK-alpha cascade\" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310]", "\"NIK/NF-kappaB cascade\" EXACT [GOC:signaling]", "\"NIK/NF-kappaB signal transduction\" EXACT [GOC:signaling]", "\"NIK/NF-kappaB signaling\" EXACT []", "\"non-canonical NF-KB signaling\" EXACT [PMID:21173796]", "\"noncanonical NF-kappaB signaling\" EXACT [PMID:20501935]", "\"noncanonical nuclear factor kappaB (NF-kappaB) pathway\" EXACT [PMID:20501935]", "\"p52-dependent NF-kappaB signaling\" NARROW [PMID:18292232]" ] } } }, { "id": "GO:0039502", "name": "symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "previous": "suppression by virus of host type I interferon-mediated signaling pathway" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.\" [GOC:add, GOC:bf, GOC:sp, PMID:19802576, PMID:26712804, PMID:32464097, PMID:32733001, PMID:33097660]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.\" [GOC:add, GOC:bf, GOC:sp, PMID:19802576, PMID:26712804, PMID:32464097, PMID:32733001, PMID:33097660]" }, "synonyms": { "current": [ "\"inhibition of host interferon signaling pathway by virus\" RELATED [UniProtKB-KW:KW-1114]", "\"negative regulation by virus of host type I interferon-mediated signaling pathway\" EXACT [GOC:bf]", "\"suppression by virus of host type I IFN-mediated signaling pathway\" EXACT [GOC:bf]", "\"suppression by virus of host type I interferon-mediated signaling pathway\" NARROW []", "\"suppression by virus of host type I interferon-mediated signalling pathway\" EXACT [GOC:bf]" ], "previous": [ "\"inhibition of host interferon signaling pathway by virus\" RELATED [UniProtKB-KW:KW-1114]", "\"negative regulation by virus of host type I interferon-mediated signaling pathway\" EXACT [GOC:bf]", "\"suppression by virus of host type I IFN-mediated signaling pathway\" EXACT [GOC:bf]", "\"suppression by virus of host type I interferon-mediated signalling pathway\" EXACT [GOC:bf]" ] } } }, { "id": "GO:0039514", "name": "symbiont-mediated suppression of host JAK-STAT cascade", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade", "previous": "disruption by virus of host JAK-STAT cascade" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp, PMID:20624917, PMID:22919663, PMID:27437422, PMID:29924996, PMID:31413201]", "previous": "\"A process in which a virus interferes with, inhibits or stops the JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp]" }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade\" NARROW []", "\"down-regulation by virus of host JAK-STAT cascade\" NARROW [GOC:bf]", "\"downregulation by virus of host JAK-STAT cascade\" NARROW [GOC:bf]", "\"inhibition by virus of host JAK-STAT cascade\" NARROW [GOC:bf]", "\"negative regulation by virus of host JAK-STAT cascade\" NARROW [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade\" NARROW []" ], "previous": [ "\"down-regulation by virus of host JAK-STAT cascade\" EXACT [GOC:bf]", "\"downregulation by virus of host JAK-STAT cascade\" EXACT [GOC:bf]", "\"inhibition by virus of host JAK-STAT cascade\" NARROW [GOC:bf]", "\"negative regulation by virus of host JAK-STAT cascade\" EXACT [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade\" EXACT []" ] } } }, { "id": "GO:0039527", "name": "symbiont-mediated suppression of host TRAF-mediated signal transduction", "changes": { "name": { "current": "symbiont-mediated suppression of host TRAF-mediated signal transduction", "previous": "disruption by virus of host TRAF-mediated signal transduction" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp, PMID:20335533, PMID:27387501, PMID:28522607, PMID:31311877, PMID:33372174]", "previous": "\"A process in which a virus interferes with, inhibits or stops TRAF-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:bf, GOC:sp, PMID:20335533, PMID:27387501, PMID:28522607, PMID:31311877, PMID:33372174]" }, "comment": { "current": "N/A", "previous": "This term is for annotation of viral proteins that counteract the host anti-viral innate immune response." }, "synonyms": { "current": [ "\"disruption by virus of host TRAF-mediated signal transduction\" NARROW []", "\"inhibition of host TRAF-mediated signal transduction by virus\" EXACT [GOC:bf]", "\"inhibition of host TRAFs by virus\" NARROW []", "\"negative regulation by virus of host TRAF-mediated signal transduction\" BROAD [GOC:bf]", "\"suppression by virus of host TRAF activity\" EXACT []", "\"suppression by virus of host TRAF-mediated signal transduction\" EXACT []", "\"suppression by virus of host tumor necrosis factor receptor-associated factor signaling\" EXACT [GOC:bf]" ], "previous": [ "\"inhibition of host TRAF-mediated signal transduction by virus\" EXACT [GOC:bf]", "\"inhibition of host TRAFs by virus\" NARROW []", "\"negative regulation by virus of host TRAF-mediated signal transduction\" BROAD [GOC:bf]", "\"suppression by virus of host TRAF activity\" EXACT []", "\"suppression by virus of host TRAF-mediated signal transduction\" EXACT []", "\"suppression by virus of host tumor necrosis factor receptor-associated factor signaling\" EXACT [GOC:bf]" ] } } }, { "id": "GO:0039537", "name": "symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.\" [GOC:bf, GOC:jl]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the host viral-induced cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.\" [GOC:bf, GOC:jl]" }, "synonyms": { "current": [ "\"suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus\" EXACT [GOC:bf]", "\"suppression by virus of host RIG-I-like receptor (RLR) signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-I/MDA5 signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-like helicase signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-like receptor signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RLR signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway\" NARROW []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway\" EXACT [GOC:mah]" ], "previous": [ "\"suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus\" EXACT [GOC:bf]", "\"suppression by virus of host RIG-I-like receptor (RLR) signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-I/MDA5 signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-like helicase signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RIG-like receptor signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host RLR signaling pathway\" RELATED [GOC:bf]", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway\" EXACT [GOC:mah]" ] } } }, { "id": "GO:0039540", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.\" [PMID:19454348, PMID:26138103]", "previous": "\"Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.\" [PMID:19454348, PMID:26138103]" }, "synonyms": { "current": [ "\"inhibition by virus of host DDX58 activity\" RELATED [GOC:sp]", "\"inhibition by virus of host RIG-I\" RELATED []", "\"inhibition by virus of host RIG-I signaling\" RELATED []", "\"inhibition of host DDX58/RIG-I by virus\" EXACT []", "\"suppression by virus of host DDX58 signaling pathway\" RELATED []", "\"suppression by virus of host RIG-I activity\" RELATED []", "\"suppression by virus of host RIG-I signaling pathway\" RELATED []", "\"suppression by virus of host RIG-I signalling pathway\" EXACT []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity\" NARROW []" ], "previous": [ "\"inhibition by virus of host DDX58 activity\" RELATED [GOC:sp]", "\"inhibition by virus of host RIG-I\" RELATED []", "\"inhibition by virus of host RIG-I signaling\" RELATED []", "\"inhibition of host DDX58/RIG-I by virus\" EXACT []", "\"suppression by virus of host DDX58 signaling pathway\" RELATED []", "\"suppression by virus of host RIG-I activity\" RELATED []", "\"suppression by virus of host RIG-I signaling pathway\" RELATED []", "\"suppression by virus of host RIG-I signalling pathway\" EXACT []" ] } } }, { "id": "GO:0039545", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.\" [PMID:17438296, PMID:22674996]", "previous": "\"Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.\" [PMID:17438296, PMID:22674996]" }, "synonyms": { "current": [ "\"inhibition of host MAVS by virus\" RELATED []", "\"suppression by virus of host MAVS activity\" RELATED []", "\"suppression by virus of host mitochondrial antiviral-signaling protein\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity\" NARROW []" ], "previous": [ "\"inhibition of host MAVS by virus\" RELATED []", "\"suppression by virus of host MAVS activity\" RELATED []", "\"suppression by virus of host mitochondrial antiviral-signaling protein\" RELATED []" ] } } }, { "id": "GO:0039548", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.\" [PMID:21632562]", "previous": "\"Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.\" [PMID:21632562]" }, "synonyms": { "current": [ "\"inhibition of host IRF3 by virus\" RELATED []", "\"inhibition of IRF3-dependent antiviral response\" RELATED [PMID:19125153]", "\"suppression by virus of host interferon regulatory factor 3\" RELATED []", "\"suppression by virus of host IRF3 activity\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity\" NARROW []" ], "previous": [ "\"inhibition of host IRF3 by virus\" RELATED []", "\"inhibition of IRF3-dependent antiviral response\" RELATED [PMID:19125153]", "\"suppression by virus of host interferon regulatory factor 3\" RELATED []", "\"suppression by virus of host IRF3 activity\" RELATED []" ] } } }, { "id": "GO:0039554", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.\" [PMID:19019954, PMID:33727702]", "previous": "\"Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.\" [PMID:19019954, PMID:33727702]" }, "synonyms": { "current": [ "\"inhibition by virus of host MDA-5 signaling\" RELATED []", "\"inhibition of host IFIH1/MDA5 by virus\" RELATED []", "\"Inhibition of host MDA5 by virus\" RELATED []", "\"suppression by virus of host IFIH1 signaling pathway\" RELATED []", "\"suppression by virus of host MDA-5 activity\" RELATED []", "\"suppression by virus of host MDA-5 signaling pathway\" RELATED []", "\"suppression by virus of host MDA-5 signalling pathway\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity\" NARROW []" ], "previous": [ "\"inhibition by virus of host MDA-5 signaling\" RELATED []", "\"inhibition of host IFIH1/MDA5 by virus\" RELATED []", "\"Inhibition of host MDA5 by virus\" RELATED []", "\"suppression by virus of host IFIH1 signaling pathway\" RELATED []", "\"suppression by virus of host MDA-5 activity\" RELATED []", "\"suppression by virus of host MDA-5 signaling pathway\" RELATED []", "\"suppression by virus of host MDA-5 signalling pathway\" RELATED []" ] } } }, { "id": "GO:0039557", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.\" [PMID:11943871, PMID:16014964, PMID:19557165]", "previous": "\"Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.\" [PMID:11943871, PMID:16014964, PMID:19557165]" }, "synonyms": { "current": [ "\"inhibition of host interferon regulatory factor-7 by virus\" RELATED []", "\"inhibition of host IRF7 by virus\" RELATED []", "\"suppression by virus of host interferon regulatory factor 7 activity\" RELATED []", "\"suppression by virus of host IRF7 activity\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity\" NARROW []" ], "previous": [ "\"inhibition of host interferon regulatory factor-7 by virus\" RELATED []", "\"inhibition of host IRF7 by virus\" RELATED []", "\"suppression by virus of host interferon regulatory factor 7 activity\" RELATED []", "\"suppression by virus of host IRF7 activity\" RELATED []" ] } } }, { "id": "GO:0039560", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.\" [PMID:10388655, PMID:19109390]", "previous": "\"Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.\" [PMID:10388655, PMID:19109390]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "This term is for annotation of viral proteins that counteract the host anti-viral innate immune response." }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity\" NARROW []", "\"inhibition of host interferon regulatory factor-9 by virus\" NARROW [GOC:bf]", "\"inhibition of host IRF9 by virus\" NARROW []", "\"suppression by virus of host interferon regulatory factor 9 activity\" NARROW []", "\"suppression by virus of host IRF9 activity\" NARROW []", "\"suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity\" NARROW []" ], "previous": [ "\"inhibition of host interferon regulatory factor-9 by virus\" EXACT [GOC:bf]", "\"inhibition of host IRF9 by virus\" EXACT []", "\"suppression by virus of host interferon regulatory factor 9 activity\" RELATED []", "\"suppression by virus of host IRF9 activity\" RELATED []", "\"suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity\" EXACT []" ] } } }, { "id": "GO:0039562", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of STAT activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.\" [GOC:bf]", "previous": "\"Any process in which a virus interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.\" [GOC:bf]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "This term is for annotation of viral proteins that counteract the host anti-viral innate immune response." }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of STAT activity\" NARROW []", "\"inhibition by virus of host STAT activity\" NARROW [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT activity\" EXACT []", "\"suppression by virus of host signal transducer and activator of transcription activity\" EXACT [GOC:bf]", "\"suppression by virus of host STAT activity\" EXACT []" ], "previous": [ "\"inhibition by virus of host STAT activity\" NARROW [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT activity\" EXACT []", "\"suppression by virus of host signal transducer and activator of transcription activity\" EXACT [GOC:bf]", "\"suppression by virus of host STAT activity\" EXACT []" ] } } }, { "id": "GO:0039563", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).\" [PMID:32699158]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).\" [PMID:32699158]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "This term is for annotation of viral proteins that counteract the host anti-viral innate immune response." }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity\" NARROW []", "\"inhibition by virus of host STAT1 activity\" NARROW [GOC:bf]", "\"inhibition of host STAT1 by virus\" NARROW []", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity\" NARROW []", "\"suppression by virus of host STAT1 activity\" NARROW []" ], "previous": [ "\"inhibition by virus of host STAT1 activity\" NARROW [GOC:bf]", "\"inhibition of host STAT1 by virus\" NARROW []", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity\" EXACT []", "\"suppression by virus of host STAT1 activity\" RELATED []" ] } } }, { "id": "GO:0039564", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).\" [PMID:32699158]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).\" [PMID:32699158]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "N/A" }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity\" NARROW []", "\"inhibition by virus of host STAT2 activity\" NARROW [GOC:bf]", "\"inhibition of host STAT2 by virus\" NARROW []", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity\" NARROW []", "\"suppression by virus of host STAT2 activity\" NARROW []" ], "previous": [ "\"inhibition by virus of host STAT2 activity\" RELATED [GOC:bf]", "\"inhibition of host STAT2 by virus\" RELATED []", "\"suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity\" EXACT []", "\"suppression by virus of host STAT2 activity\" RELATED []" ] } } }, { "id": "GO:0039574", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits.\" [PMID:16987978, PMID:19085955]", "previous": "\"Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits.\" [PMID:16987978, PMID:19085955]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "N/A" }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity\" NARROW []", "\"suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity\" NARROW []", "\"suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity\" NARROW []", "\"suppression by virus of host TYK2 activity\" NARROW []" ], "previous": [ "\"suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity\" EXACT []", "\"suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity\" EXACT []", "\"suppression by virus of host TYK2 activity\" RELATED []" ] } } }, { "id": "GO:0039576", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity", "previous": "disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host JAK1 (Janus Kinase 1).\" [PMID:16188985]", "previous": "\"Any process in which interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1).\" [PMID:16188985]" }, "comment": { "current": "This term is for annotation of symbiont proteins that counteract the host innate immune response.", "previous": "N/A" }, "synonyms": { "current": [ "\"disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity\" NARROW []", "\"inhibition of host JAK activity by virus\" NARROW [GOC:bf]", "\"negative regulation by virus of host JAK\" NARROW [GOC:bf]", "\"negative regulation by virus of tyrosine phosphorylation of host STAT protein\" NARROW [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity\" NARROW []", "\"suppression by virus of host JAK1 activity\" NARROW []", "\"suppression by virus of tyrosine phosphorylation of host STAT protein\" NARROW []", "\"viral inhibition of tyrosine phosphorylation of host STAT protein\" NARROW [GOC:bf]" ], "previous": [ "\"inhibition of host JAK activity by virus\" NARROW [GOC:bf]", "\"negative regulation by virus of host JAK\" EXACT [GOC:bf]", "\"negative regulation by virus of tyrosine phosphorylation of host STAT protein\" NARROW [GOC:bf]", "\"suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity\" EXACT []", "\"suppression by virus of host JAK1 activity\" EXACT []", "\"suppression by virus of host janus kinase 1 activity\" EXACT [PR:000009196]", "\"suppression by virus of tyrosine phosphorylation of host STAT protein\" NARROW []", "\"viral inhibition of tyrosine phosphorylation of host STAT protein\" NARROW [GOC:bf]" ] } } }, { "id": "GO:0039580", "name": "symbiont-mediated suppression of host PKR/eIFalpha signaling", "changes": { "name": { "current": "symbiont-mediated suppression of host PKR/eIFalpha signaling", "previous": "suppression by virus of host PKR signaling" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response.\" [PMID:15207627]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response.\" [PMID:15207627]" }, "synonyms": { "current": [ "\"suppression by virus of host EIF2AK2 activity\" NARROW []", "\"suppression by virus of host PKR activity\" NARROW []", "\"suppression by virus of host PKR signaling\" NARROW []" ], "previous": [ "\"suppression by virus of host EIF2AK2 activity\" NARROW []", "\"suppression by virus of host PKR activity\" NARROW []" ] } } }, { "id": "GO:0039585", "name": "PKR/eIFalpha signaling", "changes": { "name": { "current": "PKR/eIFalpha signaling", "previous": "PKR-mediated signaling" }, "definition": { "current": "\"A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with inhibition of translation.\" [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576]", "previous": "\"A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.\" [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576]" } } }, { "id": "GO:0039592", "name": "symbiont-mediated arrest of host cell cycle during G2/M transition", "changes": { "name": { "current": "symbiont-mediated arrest of host cell cycle during G2/M transition", "previous": "perturbation by virus of G2/M transition of host mitotic cell cycle" }, "definition": { "current": "\"A process in which a symbiont interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. The arrest in G2/M allows some viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes.\" [PMID:10946289, PMID:12208959, PMID:9882364, VZ:876]", "previous": "\"A process in which a virus interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase.\" [UniProtKB-KW:KW-1079, VZ:876]" }, "synonyms": { "current": [ "\"host G2/M cell cycle arrest by virus\" NARROW []", "\"perturbation by virus of G2/M transition of host mitotic cell cycle\" NARROW []", "\"suppression by virus of G2/M transition of host mitotic cell cycle\" NARROW []" ], "previous": [ "\"host G2/M cell cycle arrest by virus\" EXACT [UniProtKB-KW:KW-1079]", "\"suppression by virus of G2/M transition of host mitotic cell cycle\" RELATED []" ] } } }, { "id": "GO:0039593", "name": "symbiont-mediated perturbation of host exit from mitosis", "changes": { "name": { "current": "symbiont-mediated perturbation of host exit from mitosis", "previous": "peturbation by virus of host exit from mitosis" }, "definition": { "current": "\"A process in which a virus interferes with the host cell completing the M phase of the cell cycle.\" [VZ:877]", "previous": "\"A process in which a virus interferes with the host cell completing the M phase of the cell cycle.\" [UniProtKB-KW:KW-1098, VZ:877]" }, "synonyms": { "current": [ "\"inhibition of host mitotic exit by virus\" EXACT [UniProtKB-KW:KW-1098, VZ:877]", "\"perturbation by virus of host exit from mitosis\" NARROW []", "\"suppression by virus of host exit from mitosis\" RELATED []" ], "previous": [ "\"inhibition of host mitotic exit by virus\" EXACT [UniProtKB-KW:KW-1098, VZ:877]", "\"suppression by virus of host exit from mitosis\" RELATED []" ] } } }, { "id": "GO:0039645", "name": "symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint", "changes": { "name": { "current": "symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint", "previous": "perturbation by virus of host G1/S transition checkpoint" }, "definition": { "current": "\"A process in which a symbiont interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:24501404, VZ:880]", "previous": "\"A process in which a virus interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [UniProtKB-KW:KW-1078]" }, "synonyms": { "current": [ "\"G1/S host cell cycle checkpoint dysregulation by virus\" EXACT [VZ:880]", "\"modulation by virus of host G1/S transition checkpoint\" RELATED []", "\"perturbation by virus of host G1/S transition checkpoint\" NARROW []" ], "previous": [ "\"G1/S host cell cycle checkpoint dysregulation by virus\" EXACT [UniProtKB-KW:KW-1078, VZ:880]", "\"modulation by virus of host G1/S transition checkpoint\" RELATED []" ] } } }, { "id": "GO:0039646", "name": "symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint", "changes": { "name": { "current": "symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint", "previous": "perturbation by virus of host G0/G1 transition checkpoint" }, "definition": { "current": "\"A process in which a symbiont interferes with the normal execution of the host cell G0/G1 transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction. Some viruses benefit from keeping cells in resting state (G0), while others favor entry through G1 and subsequent cell division to replicate more efficiently.\" [VZ:880]", "previous": "\"A process in which a virus interferes with the normal execution of the host cell G0/G1 transition checkpoint.\" [UniProtKB-KW:KW-1077]" }, "synonyms": { "current": [ "\"G0/G1 host cell cycle checkpoint dysregulation by virus\" NARROW [UniProtKB-KW:KW-1077, VZ:881]", "\"modulation by virus of host G0/G1 transition checkpoint\" NARROW []", "\"perturbation by virus of host G0/G1 transition checkpoint\" NARROW []" ], "previous": [ "\"G0/G1 host cell cycle checkpoint dysregulation by virus\" EXACT [UniProtKB-KW:KW-1077, VZ:881]", "\"modulation by virus of host G0/G1 transition checkpoint\" RELATED []" ] } } }, { "id": "GO:0039648", "name": "symbiont-mediated perturbation of host protein ubiquitination", "changes": { "name": { "current": "symbiont-mediated perturbation of host protein ubiquitination", "previous": "modulation by symbiont of host protein ubiquitination" }, "definition": { "current": "\"A process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism.\" [PMID:25166298, PMID:26483404, PMID:26712804]", "previous": "\"Any process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism.\" [PMID:25166298, PMID:26483404, PMID:26712804]" }, "synonyms": { "current": [ "\"modulation by symbiont of host protein ubiquitination\" EXACT []", "\"modulation of host ubiquitin pathway by virus\" NARROW []" ], "previous": [ "\"modulation of host ubiquitin pathway by virus\" NARROW []" ] } } }, { "id": "GO:0039678", "name": "symbiont genome ejection through host cell envelope", "changes": { "name": { "current": "symbiont genome ejection through host cell envelope", "previous": "viral genome ejection through host cell envelope" }, "definition": { "current": "\"Entry of a symbiont's genome into the host cell through the host cell envelope. Occurs in non-enveloped prokaryotic viruses. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm.\" [GOC:ch, PMID:23385786, PMID:31663016, VZ:986]", "previous": "\"Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm.\" [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171]" }, "comment": { "current": "N/A", "previous": "When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'." }, "synonyms": { "current": [ "\"phage genome ejection\" NARROW [PMID:23385786]", "\"viral genome ejection through host cell envelope\" RELATED []", "\"viral genome injection through bacterial membranes\" NARROW [VZ:986]" ], "previous": [ "\"phage genome ejection\" NARROW [PMID:23385786]", "\"viral genome injection through bacterial membranes\" NARROW [UniProtKB-KW:KW-1171]" ] } } }, { "id": "GO:0039699", "name": "evasion of mRNA degradation by host via mRNA cap methylation", "changes": { "name": { "current": "evasion of mRNA degradation by host via mRNA cap methylation", "previous": "viral mRNA cap methylation" }, "definition": { "current": "\"An innate immune response evasion mechanism in which a symbiont methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. This mechanism of immune evasion is used by viruses.\" [PMID:35215972]", "previous": "\"An innate immune response evasion mechanism in which a virus methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs.\" [PMID:35215972]" }, "synonyms": { "current": [ "\"IFIT mRNA restriction evasion by virus\" EXACT [PMID:35215972]", "\"viral mRNA cap methylation\" RELATED []" ], "previous": [ "\"IFIT mRNA restriction evasion by virus\" EXACT [PMID:35215972]" ] } } }, { "id": "GO:0039722", "name": "symbiont-mediated suppression of host toll-like receptor signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of host toll-like receptor signaling pathway", "previous": "suppression by virus of host toll-like receptor signaling pathway" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:15944308, PMID:17299722, PMID:18327267]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism.\" [UniProtKB-KW:KW-1225]" }, "synonyms": { "current": [ "\"inhibition of host TLR pathway by virus\" NARROW []", "\"suppression by virus of host TLR signaling pathway\" NARROW []", "\"suppression by virus of host toll-like receptor signaling pathway\" NARROW []" ], "previous": [ "\"inhibition of host TLR pathway by virus\" EXACT [UniProtKB-KW:KW-1125]", "\"suppression by virus of host TLR signaling pathway\" EXACT []" ] } } }, { "id": "GO:0039723", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity" }, "definition": { "current": "\"Any process in which a symbiont stops, prevents, or reduces a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1.\" [PMID:22171259, PMID:34084167]", "previous": "\"Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1.\" [PMID:22171259, PMID:34084167]" }, "synonyms": { "current": [ "\"inhibition of host TBK1 by virus\" RELATED []", "\"suppression by virus of host TBK1 activity\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity\" NARROW []" ], "previous": [ "\"inhibition of host TBK1 by virus\" RELATED []", "\"suppression by virus of host TBK1 activity\" RELATED []" ] } } }, { "id": "GO:0039724", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity", "changes": { "name": { "current": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity", "previous": "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E).\" [PMID:19153231, PMID:22532683, PMID:24173023]", "previous": "\"Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E).\" [PMID:19153231, PMID:22532683, PMID:24173023]" }, "synonyms": { "current": [ "\"inhibition of host IKBKE by virus\" RELATED []", "\"suppression by virus of host IKBKE activity\" RELATED []", "\"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity\" NARROW []" ], "previous": [ "\"inhibition of host IKBKE by virus\" RELATED []", "\"suppression by virus of host IKBKE activity\" RELATED []" ] } } }, { "id": "GO:0040033", "name": "sRNA-mediated post-transcriptional gene silencing", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0042178", "name": "xenobiotic catabolic process", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0042254", "name": "ribosome biogenesis", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0042758", "name": "long-chain fatty acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [PMID:20043225]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [PMID:20043225]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0042759", "name": "long-chain fatty acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [PMID:18390550]", "previous": "\"The chemical reactions and pathways resulting in the formation of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [PMID:18390550]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0042760", "name": "very long-chain fatty acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.\" [PMID:7744868]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons.\" [PMID:7744868]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0042761", "name": "very long-chain fatty acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.\" [PMID:7744868]", "previous": "\"The chemical reactions and pathways resulting in the formation of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons.\" [PMID:7744868]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0042784", "name": "symbiont-mediated suppression of host complement activation", "changes": { "name": { "current": "symbiont-mediated suppression of host complement activation", "previous": "evasion of host immune response via modulation of host complement system" }, "definition": { "current": "\"A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:20194595, PMID:21191012, PMID:25830295, PMID:7745740]", "previous": "\"Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]" }, "synonyms": { "current": [ "\"active evasion of host immune response via regulation of host complement system\" RELATED []", "\"active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion via modulation of host complement system\" EXACT []", "\"active immune evasion via regulation of host complement system\" EXACT []", "\"evasion of host immune response via modulation of host complement system\" EXACT []", "\"evasion of host immune response via regulation of host complement system\" EXACT []", "\"suppression of complement activation by another organism\" BROAD []" ], "previous": [ "\"active evasion of host immune response via regulation of host complement system\" RELATED []", "\"active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction\" BROAD []", "\"active immune evasion via modulation of host complement system\" EXACT []", "\"active immune evasion via regulation of host complement system\" EXACT []", "\"evasion of host immune response via regulation of host complement system\" EXACT []" ] } } }, { "id": "GO:0043062", "name": "extracellular structure organization", "changes": { "subsets": { "current": [ "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0043491", "name": "phosphatidylinositol 3-kinase/protein kinase B signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway.\" [PMID:20517722, PMID:22952397]", "previous": "\"An intracellular signal transduction pathway that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway.\" [PMID:20517722, PMID:22952397]" } } }, { "id": "GO:0044029", "name": "positive regulation of gene expression via CpG island demethylation", "changes": { "synonyms": { "current": [ "\"DNA demethylation\" BROAD []", "\"DNA hypomethylation of CpG island\" EXACT []", "\"hypomethylation of CpG island\" EXACT []" ], "previous": [ "\"DNA hypomethylation of CpG island\" EXACT []", "\"hypomethylation of CpG island\" EXACT []" ] } } }, { "id": "GO:0044071", "name": "symbiont-mediated perturbation of host cell cycle progression", "changes": { "name": { "current": "symbiont-mediated perturbation of host cell cycle progression", "previous": "perturbation of host cell cycle progression" }, "synonyms": { "current": [ "\"modification by symbiont of host cell cycle\" EXACT []", "\"modulation by symbiont of host cell cycle\" EXACT []", "\"modulation of host cell cycle by symbiont\" EXACT []", "\"perturbation of host cell cycle progression\" EXACT []", "\"regulation by symbiont of host cell cycle\" EXACT []" ], "previous": [ "\"modification by symbiont of host cell cycle\" EXACT []", "\"modulation by symbiont of host cell cycle\" EXACT []", "\"modulation of host cell cycle by symbiont\" EXACT []", "\"regulation by symbiont of host cell cycle\" EXACT []" ] } } }, { "id": "GO:0044075", "name": "symbiont-mediated perturbation of host vacuole organization", "changes": { "definition": { "current": "\"Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism.\" [PMID:25139904]", "previous": "\"Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism.\" [MITRE:tk]" } } }, { "id": "GO:0044080", "name": "symbiont-mediated perturbation of host cGMP-mediated signal transduction", "changes": { "name": { "current": "symbiont-mediated perturbation of host cGMP-mediated signal transduction", "previous": "perturbation of host cGMP-mediated signal transduction" }, "synonyms": { "current": [ "\"modulation by symbiont of host cGMP-mediated signal transduction\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signal transduction pathway\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signaling\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signalling\" EXACT []", "\"modulation of host cGMP-mediated signal transduction by symbiont\" EXACT []", "\"perturbation of host cGMP-mediated signal transduction\" EXACT []", "\"regulation by symbiont of host cGMP-mediated signal transduction\" EXACT []" ], "previous": [ "\"modulation by symbiont of host cGMP-mediated signal transduction\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signal transduction pathway\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signaling\" EXACT []", "\"modulation by symbiont of host cGMP-mediated signalling\" EXACT []", "\"modulation of host cGMP-mediated signal transduction by symbiont\" EXACT []", "\"regulation by symbiont of host cGMP-mediated signal transduction\" EXACT []" ] } } }, { "id": "GO:0044082", "name": "symbiont-mediated perturbation of host small GTPase-mediated signal transduction", "changes": { "name": { "current": "symbiont-mediated perturbation of host small GTPase-mediated signal transduction", "previous": "perturbation of host small GTPase mediated signal transduction" }, "synonyms": { "current": [ "\"modulation by symbiont of host small GTPase mediated signal transduction\" EXACT []", "\"modulation of host small GTPase mediated signal transduction by symbiont\" EXACT []", "\"perturbation of host small GTPase mediated signal transduction\" EXACT []", "\"regulation by symbiont of host small GTPase mediated signal transduction\" EXACT []" ], "previous": [ "\"modulation by symbiont of host small GTPase mediated signal transduction\" EXACT []", "\"modulation of host small GTPase mediated signal transduction by symbiont\" EXACT []", "\"regulation by symbiont of host small GTPase mediated signal transduction\" EXACT []" ] } } }, { "id": "GO:0044083", "name": "symbiont-mediated perturbation of host Rho signal transduction", "changes": { "name": { "current": "symbiont-mediated perturbation of host Rho signal transduction", "previous": "perturbation of host Rho protein signal transduction" }, "definition": { "current": "\"A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:15694861, PMID:17689917, PMID:30201700]", "previous": "\"A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [MITRE:tk]" }, "synonyms": { "current": [ "\"modulation by symbiont of host Rho protein mediated signal transduction\" EXACT []", "\"modulation by symbiont of host Rho protein signal transduction\" EXACT []", "\"modulation by symbiont of host Rho protein-mediated signal transduction\" EXACT []", "\"modulation of host Rho protein signal transduction by symbiont\" EXACT []", "\"modulation of host Rho protein signaling by symbiont\" EXACT []", "\"modulation of host Rho protein signalling by symbiont\" EXACT []", "\"perturbation of host Rho protein signal transduction\" EXACT []", "\"regulation by symbiont of host Rho protein signal transduction\" EXACT []", "\"symbiont-mediated perturbation of host Rho protein signal transduction\" EXACT []" ], "previous": [ "\"modulation by symbiont of host Rho protein mediated signal transduction\" EXACT []", "\"modulation by symbiont of host Rho protein signal transduction\" EXACT []", "\"modulation by symbiont of host Rho protein-mediated signal transduction\" EXACT []", "\"modulation of host Rho protein signal transduction by symbiont\" EXACT []", "\"modulation of host Rho protein signaling by symbiont\" EXACT []", "\"modulation of host Rho protein signalling by symbiont\" EXACT []", "\"regulation by symbiont of host Rho protein signal transduction\" EXACT []" ] } } }, { "id": "GO:0044283", "name": "small molecule biosynthetic process", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0044409", "name": "symbiont entry into host", "changes": { "name": { "current": "symbiont entry into host", "previous": "entry into host" }, "synonyms": { "current": [ "\"entry into cell of other organism during symbiotic interaction\" NARROW [GOC:tb]", "\"entry into cell of other organism involved in symbiotic interaction\" RELATED []", "\"entry into host\" EXACT []", "\"entry into host cell via penetration peg\" NARROW []", "\"entry into host through host barriers\" RELATED []", "\"entry into host via a specialized structure during symbiotic interaction\" NARROW []", "\"entry into host via enzymatic degradation of host anatomical structure\" NARROW []", "\"entry into host via enzymatic degradation of host cuticle\" NARROW []", "\"entry into other organism during symbiotic interaction\" RELATED [GOC:tb]", "\"entry into other organism involved in symbiotic interaction\" RELATED []", "\"host invasion\" EXACT []", "\"host penetration\" EXACT [GOC:vw]", "\"invasion into host\" EXACT []", "\"invasion into other organism\" RELATED []", "\"invasion of host\" EXACT []", "\"invasion of other organism\" RELATED []", "\"invasive growth\" RELATED []", "\"other organism invasion\" RELATED []", "\"penetration into host\" EXACT [GOC:vw]", "\"penetration into host via a specialized structure\" NARROW [GOC:vw]", "\"penetration into host via a specialized structure during symbiotic interaction\" NARROW [GOC:vw]" ], "previous": [ "\"entry into cell of other organism during symbiotic interaction\" NARROW [GOC:tb]", "\"entry into cell of other organism involved in symbiotic interaction\" RELATED []", "\"entry into host cell\" NARROW []", "\"entry into host cell via penetration peg\" NARROW []", "\"entry into host through host barriers\" RELATED []", "\"entry into host via a specialized structure during symbiotic interaction\" NARROW []", "\"entry into host via enzymatic degradation of host anatomical structure\" NARROW []", "\"entry into host via enzymatic degradation of host cuticle\" NARROW []", "\"entry into other organism during symbiotic interaction\" RELATED [GOC:tb]", "\"entry into other organism involved in symbiotic interaction\" RELATED []", "\"host cell invasion\" NARROW []", "\"host invasion\" EXACT []", "\"host penetration\" EXACT [GOC:vw]", "\"invasion into host\" EXACT []", "\"invasion into other organism\" RELATED []", "\"invasion of host\" EXACT []", "\"invasion of other organism\" RELATED []", "\"invasive growth\" RELATED []", "\"other organism cell invasion\" NARROW []", "\"other organism invasion\" RELATED []", "\"penetration into host\" EXACT [GOC:vw]", "\"penetration into host via a specialized structure\" NARROW [GOC:vw]", "\"penetration into host via a specialized structure during symbiotic interaction\" NARROW [GOC:vw]" ] } } }, { "id": "GO:0044414", "name": "symbiont-mediated suppression of host defenses", "changes": { "name": { "current": "symbiont-mediated suppression of host defenses", "previous": "suppression of host defenses by symbiont" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts the normal execution of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:curators]", "previous": "\"Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:cc]" }, "synonyms": { "current": [ "\"down regulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"down regulation by symbiont of host defense response\" EXACT []", "\"down-regulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"down-regulation by symbiont of host defense response\" EXACT []", "\"downregulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"downregulation by symbiont of host defense response\" EXACT []", "\"inhibition by organism of defense response of other organism during symbiotic interaction\" NARROW []", "\"inhibition by symbiont of host defense response\" NARROW []", "\"negative regulation by organism of defense response of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"negative regulation by organism of defense response of other organism involved in symbiotic interaction\" EXACT []", "\"negative regulation by symbiont of host defense response\" EXACT []", "\"negative regulation of host defenses\" EXACT []", "\"suppression of defense response of other organism\" EXACT []", "\"suppression of defense response of other organism involved in symbiotic interaction\" RELATED []", "\"suppression of defenses of other organism involved in symbiotic interaction\" BROAD []", "\"suppression of host defense response\" EXACT []", "\"suppression of host defenses by symbiont\" EXACT []" ], "previous": [ "\"down regulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"down regulation by symbiont of host defense response\" EXACT []", "\"down-regulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"down-regulation by symbiont of host defense response\" EXACT []", "\"downregulation by organism of defense response of other organism during symbiotic interaction\" RELATED []", "\"downregulation by symbiont of host defense response\" EXACT []", "\"inhibition by organism of defense response of other organism during symbiotic interaction\" NARROW []", "\"inhibition by symbiont of host defense response\" NARROW []", "\"negative regulation by organism of defense response of other organism during symbiotic interaction\" RELATED [GOC:dph]", "\"negative regulation by organism of defense response of other organism involved in symbiotic interaction\" EXACT []", "\"negative regulation by symbiont of host defense response\" EXACT []", "\"negative regulation of host defenses\" EXACT []", "\"suppression of defense response of other organism\" EXACT []", "\"suppression of defense response of other organism involved in symbiotic interaction\" RELATED []", "\"suppression of defenses of other organism involved in symbiotic interaction\" BROAD []", "\"suppression of host defense response\" EXACT []" ] } } }, { "id": "GO:0044523", "name": "envenomation resulting in damage of muscle extracellular matrix in another organism", "changes": { "definition": { "current": "\"A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism.\" [GOC:fj, GOC:jl, PMID:20398688, PMID:21150580, PMID:33460638]", "previous": "\"A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism.\" [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]" } } }, { "id": "GO:0044539", "name": "long-chain fatty acid import into cell", "changes": { "definition": { "current": "\"The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:jl, GOC:pm, PMID:22022213]", "previous": "\"The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:jl, GOC:pm, PMID:22022213]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0044550", "name": "secondary metabolite biosynthetic process", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0044694", "name": "symbiont genome entry into host cell via pore formation in plasma membrane", "changes": { "name": { "current": "symbiont genome entry into host cell via pore formation in plasma membrane", "previous": "pore-mediated entry of viral genome into host cell" }, "definition": { "current": "\"Entry of a symbiont's genome into a host cell by a pore formed by the symbiont in the host cell. Examples of this process include injection by a non-enveloped virus of the viral genome into the host cytoplasm, usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail.\" [GOC:jl, VZ:979]", "previous": "\"Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail.\" [GOC:jl, UniProtKB-KW:KW-1172, VZ:979]" }, "synonyms": { "current": [ "\"membrane puncture-mediated penetration of viral genome into host cell\" RELATED [UniProtKB-KW:KW-1172]", "\"pore-mediated entry of viral genome into host cell\" NARROW []", "\"pore-mediated penetration of viral genome into host cell\" RELATED []", "\"viral entry via genome injection\" RELATED []", "\"viral genome delivery via icosahedral vertex\" NARROW []", "\"viral genome translocation\" EXACT []", "\"viral pore-forming protein\" NARROW [GOC:bf]" ], "previous": [ "\"membrane puncture-mediated penetration of viral genome into host cell\" RELATED [UniProtKB-KW:KW-1172]", "\"pore-mediated penetration of viral genome into host cell\" EXACT []", "\"viral entry via genome injection\" EXACT []", "\"viral genome delivery via icosahedral vertex\" NARROW []", "\"viral genome translocation\" EXACT []", "\"viral pore-forming protein\" RELATED [GOC:bf]" ] } } }, { "id": "GO:0045022", "name": "early endosome to late endosome transport", "changes": { "definition": { "current": "\"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.\" [ISBN:0815316194, PMID:29980602]", "previous": "\"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.\" [ISBN:0815316194]" }, "synonyms": { "current": [ "\"endosome maturation\" RELATED [PMID:21878991, PMID:29980602]" ], "previous": "N/A" } } }, { "id": "GO:0045815", "name": "transcription initiation-coupled chromatin remodeling", "changes": { "synonyms": { "current": [ "\"chromatin-mediated maintenance of transcription\" EXACT []", "\"DNA replication-independent chromatin organization\" RELATED []", "\"epigenetic maintenance of chromatin in transcription-competent conformation\" EXACT []", "\"euchromatin assembly\" RELATED []", "\"euchromatin organisation\" RELATED []", "\"euchromatin organization\" RELATED []", "\"long-term maintenance of gene activation\" RELATED []", "\"maintenance of chromatin in transcription-competent conformation\" EXACT []", "\"transciptional initiation-coupled chromatin remodeling\" EXACT []", "\"transciptional initiation-coupled chromatin remodelling\" EXACT []", "\"transcription initiation coupled chromatin remodeling\" EXACT []", "\"transcription initiation coupled chromatin remodelling\" EXACT []", "\"transcriptional initiation-coupled chromatin remodeling\" EXACT []", "\"transcriptional initiation-coupled chromatin remodelling\" EXACT []" ], "previous": [ "\"activation of gene expression, epigenetic\" RELATED []", "\"chromatin-mediated maintenance of transcription\" EXACT []", "\"DNA replication-independent chromatin organization\" RELATED []", "\"epigenetic maintenance of chromatin in transcription-competent conformation\" EXACT []", "\"euchromatin assembly\" RELATED []", "\"euchromatin organisation\" RELATED []", "\"euchromatin organization\" RELATED []", "\"long-term maintenance of gene activation\" RELATED []", "\"maintenance of chromatin in transcription-competent conformation\" EXACT []", "\"positive regulation of gene expression, epigenetic\" EXACT []", "\"stimulation of gene expression, epigenetic\" RELATED []", "\"transciptional initiation-coupled chromatin remodeling\" EXACT []", "\"transciptional initiation-coupled chromatin remodelling\" EXACT []", "\"transcription initiation coupled chromatin remodeling\" EXACT []", "\"transcription initiation coupled chromatin remodelling\" EXACT []", "\"transcriptional initiation-coupled chromatin remodeling\" EXACT []", "\"transcriptional initiation-coupled chromatin remodelling\" EXACT []", "\"up regulation of gene expression, epigenetic\" EXACT []", "\"up-regulation of gene expression, epigenetic\" EXACT []", "\"upregulation of gene expression, epigenetic\" EXACT []" ] } } }, { "id": "GO:0046459", "name": "short-chain fatty acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [Wikipedia:Fatty_acid_metabolism]", "previous": "\"The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons.\" [Wikipedia:Fatty_acid_metabolism]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0046718", "name": "symbiont entry into host cell", "changes": { "name": { "current": "symbiont entry into host cell", "previous": "viral entry into host cell" }, "definition": { "current": "\"The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell.\" [GOC:jl]", "previous": "\"The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.\" [GOC:jl]" }, "synonyms": { "current": [ "\"entry of virus into host cell\" NARROW []", "\"phage translocation\" NARROW []", "\"viral entry into host cell\" NARROW []", "\"viral penetration\" NARROW []", "\"virion penetration\" NARROW []", "\"virion penetration into host cell\" NARROW []", "\"virus entry into host cell\" NARROW []" ], "previous": [ "\"entry of virus into host cell\" EXACT []", "\"phage translocation\" EXACT []", "\"viral penetration\" EXACT []", "\"virion penetration\" EXACT []", "\"virion penetration into host cell\" EXACT []", "\"virus entry into host cell\" EXACT [GOC:bf]" ] } } }, { "id": "GO:0046925", "name": "peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine", "changes": { "definition": { "current": "\"The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine.\" [PMID:12696888, PMID:36302388, RESID:AA0341]", "previous": "\"The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine.\" [PMID:12696888, RESID:AA0341]" } } }, { "id": "GO:0046926", "name": "peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine", "changes": { "definition": { "current": "\"The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine.\" [PMID:12696888, PMID:36302388, RESID:AA0342]", "previous": "\"The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine.\" [PMID:12696888, RESID:AA0342]" } } }, { "id": "GO:0048870", "name": "cell motility", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0050896", "name": "response to stimulus", "changes": { "subsets": { "current": [ "gocheck_do_not_manually_annotate", "goslim_agr", "goslim_flybase_ribbon", "goslim_mouse", "goslim_pir", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_manually_annotate", "goslim_agr", "goslim_flybase_ribbon", "goslim_mouse", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0051604", "name": "protein maturation", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0051790", "name": "short-chain fatty acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [Wikipedia:Fatty_acid_metabolism]", "previous": "\"The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of less than 6 carbons.\" [Wikipedia:Fatty_acid_metabolism]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0051791", "name": "medium-chain fatty acid metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolisms]", "previous": "\"The chemical reactions and pathways involving a medium-chain fatty acid, a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolisms]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0051792", "name": "medium-chain fatty acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolism]", "previous": "\"The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolism]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0051793", "name": "medium-chain fatty acid catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolism]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of 6 to 12 carbons.\" [Wikipedia:Fatty_acid_metabolism]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0052026", "name": "symbiont-mediated perturbation of host transcription", "changes": { "name": { "current": "symbiont-mediated perturbation of host transcription", "previous": "modulation by symbiont of host transcription" }, "definition": { "current": "\"A process by which a symbiont alters or subverts the normal execution of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]", "previous": "\"Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"modulation by symbiont of host transcription\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0052027", "name": "symbiont-mediated perturbation of host signal transduction pathway", "changes": { "name": { "current": "symbiont-mediated perturbation of host signal transduction pathway", "previous": "perturbation of host signal transduction pathway" }, "synonyms": { "current": [ "\"modulation by symbiont of host signal transduction\" RELATED []", "\"modulation by symbiont of host signal transduction pathway\" EXACT []", "\"modulation of host signal transduction by symbiont\" EXACT []", "\"modulation of signal transduction in other organism involved in symbiotic interaction\" BROAD []", "\"perturbation of host signal transduction pathway\" EXACT []", "\"regulation by symbiont of host signal transduction pathway\" EXACT []" ], "previous": [ "\"modulation by symbiont of host signal transduction\" RELATED []", "\"modulation by symbiont of host signal transduction pathway\" EXACT []", "\"modulation of host signal transduction by symbiont\" EXACT []", "\"modulation of signal transduction in other organism involved in symbiotic interaction\" BROAD []", "\"regulation by symbiont of host signal transduction pathway\" EXACT []" ] } } }, { "id": "GO:0052064", "name": "symbiont-mediated activation of reactive oxygen species production in host cell", "changes": { "name": { "current": "symbiont-mediated activation of reactive oxygen species production in host cell", "previous": "induction by symbiont of defense-related host reactive oxygen species production" }, "definition": { "current": "\"The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:30823485]", "previous": "\"The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"activation by symbiont of defense-related host metabolic burst\" EXACT []", "\"activation by symbiont of defense-related host oxidative burst\" EXACT []", "\"activation by symbiont of defense-related host reactive oxidative species production\" EXACT []", "\"activation by symbiont of defense-related host reactive oxygen intermediate production\" EXACT []", "\"activation by symbiont of defense-related host reactive oxygen species production\" EXACT []", "\"activation by symbiont of defense-related host respiratory burst\" EXACT []", "\"activation by symbiont of defense-related host ROI production\" EXACT []", "\"activation by symbiont of defense-related host ROS production\" EXACT []", "\"induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"induction by symbiont of defense-related host active oxygen species production\" EXACT []", "\"induction by symbiont of defense-related host AOS production\" EXACT []", "\"induction by symbiont of defense-related host metabolic burst\" EXACT []", "\"induction by symbiont of defense-related host oxidative burst\" EXACT []", "\"induction by symbiont of defense-related host reactive oxidative species production\" EXACT []", "\"induction by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"positive regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"stimulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"up regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"up-regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"upregulation by symbiont of defense-related host reactive oxygen species production\" RELATED []" ], "previous": [ "\"activation by symbiont of defense-related host metabolic burst\" EXACT []", "\"activation by symbiont of defense-related host oxidative burst\" EXACT []", "\"activation by symbiont of defense-related host reactive oxidative species production\" EXACT []", "\"activation by symbiont of defense-related host reactive oxygen intermediate production\" EXACT []", "\"activation by symbiont of defense-related host reactive oxygen species production\" EXACT []", "\"activation by symbiont of defense-related host respiratory burst\" EXACT []", "\"activation by symbiont of defense-related host ROI production\" EXACT []", "\"activation by symbiont of defense-related host ROS production\" EXACT []", "\"induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"induction by symbiont of defense-related host active oxygen species production\" EXACT []", "\"induction by symbiont of defense-related host AOS production\" EXACT []", "\"induction by symbiont of defense-related host metabolic burst\" EXACT []", "\"induction by symbiont of defense-related host oxidative burst\" EXACT []", "\"induction by symbiont of defense-related host reactive oxidative species production\" EXACT []", "\"induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction\" BROAD []", "\"positive regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"stimulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"up regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"up-regulation by symbiont of defense-related host reactive oxygen species production\" RELATED []", "\"upregulation by symbiont of defense-related host reactive oxygen species production\" RELATED []" ] } } }, { "id": "GO:0052078", "name": "symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway", "changes": { "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:18005697]", "previous": "\"A process in which a virus interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:18005697]" }, "synonyms": { "current": [ "\"disruption of host PAMP receptor signaling pathway\" EXACT []", "\"disruption of host pathogen-associated molecular pattern receptor signaling pathway\" EXACT []", "\"suppression of host pathogen-associated molecular pattern receptor signaling pathway\" NARROW []" ], "previous": [ "\"disruption of defense-related host MAP kinase-mediated signal transduction pathway\" NARROW []", "\"disruption of host PAMP receptor signaling pathway\" EXACT []", "\"disruption of host pathogen-associated molecular pattern receptor signaling pathway\" EXACT []", "\"inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway\" NARROW []", "\"suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway\" NARROW []", "\"suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway\" NARROW []", "\"suppression of host pathogen-associated molecular pattern receptor signaling pathway\" NARROW []" ] } } }, { "id": "GO:0052080", "name": "symbiont-mediated perturbation of host MAPK cascade", "changes": { "name": { "current": "symbiont-mediated perturbation of host MAPK cascade", "previous": "perturbation of host MAPK signal transduction pathway" }, "synonyms": { "current": [ "\"modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway\" RELATED []", "\"modulation by symbiont of host innate immune response MAPK kinase signaling\" NARROW []", "\"modulation of defense-related host MAPK-mediated signal transduction pathway by organism\" NARROW []", "\"modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism\" NARROW []", "\"pertubation of host innate immune response MAPK kinase signaling\" NARROW []", "\"perturbation by symbiont of host MAP kinase signal transduction pathway\" EXACT []", "\"perturbation of host MAP signal transduction pathway\" EXACT []", "\"perturbation of host MAPK kinase signaling pathway\" EXACT []", "\"perturbation of host MAPK signal transduction pathway\" EXACT []" ], "previous": [ "\"modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway\" RELATED []", "\"modulation by symbiont of host innate immune response MAPK kinase signaling\" NARROW []", "\"modulation of defense-related host MAPK-mediated signal transduction pathway by organism\" NARROW []", "\"modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism\" NARROW []", "\"pertubation of host innate immune response MAPK kinase signaling\" NARROW []", "\"perturbation by symbiont of host MAP kinase signal transduction pathway\" EXACT []", "\"perturbation of host MAP signal transduction pathway\" EXACT []", "\"perturbation of host MAPK kinase signaling pathway\" EXACT []" ] } } }, { "id": "GO:0052081", "name": "symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway", "changes": { "name": { "current": "symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway", "previous": "perturbation of defense-related host salicylic acid-mediated signal transduction pathway" }, "synonyms": { "current": [ "\"modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway\" EXACT []", "\"modulation of defense-related host SA-mediated signal transduction pathway by organism\" EXACT []", "\"perturbation of defense-related host salicylic acid-mediated signal transduction pathway\" EXACT []" ], "previous": [ "\"modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction\" BROAD []", "\"modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway\" EXACT []", "\"modulation of defense-related host SA-mediated signal transduction pathway by organism\" EXACT []" ] } } }, { "id": "GO:0052103", "name": "induction of host induced systemic resistance", "changes": { "definition": { "current": "\"Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06, PMID:31516360]", "previous": "\"Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" } } }, { "id": "GO:0052170", "name": "symbiont-mediated suppression of host innate immune response", "changes": { "name": { "current": "symbiont-mediated suppression of host innate immune response", "previous": "suppression of host innate immune response" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]", "previous": "\"Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"down regulation by symbiont of host innate immunity\" EXACT []", "\"down-regulation by symbiont of host innate immunity\" EXACT []", "\"downregulation by symbiont of host innate immunity\" EXACT []", "\"inhibition by symbiont of host innate immunity\" NARROW []", "\"negative regulation by symbiont of host innate immune response\" EXACT []", "\"negative regulation by symbiont of host innate immunity\" EXACT [GOC:pg]", "\"negative regulation of host innate immune response\" EXACT []", "\"negative regulation of innate immune response in other organism\" BROAD []", "\"suppression by symbiont of host innate immune response\" EXACT []", "\"suppression of host innate immune response\" EXACT []" ], "previous": [ "\"down regulation by symbiont of host innate immunity\" EXACT []", "\"down-regulation by symbiont of host innate immunity\" EXACT []", "\"downregulation by symbiont of host innate immunity\" EXACT []", "\"inhibition by symbiont of host innate immunity\" NARROW []", "\"negative regulation by symbiont of host innate immune response\" EXACT []", "\"negative regulation by symbiont of host innate immunity\" EXACT [GOC:pg]", "\"negative regulation of host innate immune response\" EXACT []", "\"negative regulation of innate immune response in other organism\" BROAD []", "\"suppression by symbiont of host innate immune response\" EXACT []" ] } } }, { "id": "GO:0052562", "name": "symbiont-mediated suppression of host immune response", "changes": { "name": { "current": "symbiont-mediated suppression of host immune response", "previous": "suppression by symbiont of host immune response" }, "definition": { "current": "\"Any process in which a symbiont interferes with, inhibits or disrupts the normal execution of an immune response of the host organism. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]", "previous": "\"Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:mtg_pamgo_17jul06]" }, "synonyms": { "current": [ "\"down regulation by symbiont of host immune response\" EXACT []", "\"down-regulation by symbiont of host immune response\" EXACT []", "\"downregulation by symbiont of host immune response\" EXACT []", "\"inhibition by symbiont of host immune response\" NARROW []", "\"negative regulation by organism of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"negative regulation by symbiont of host immune response\" EXACT []", "\"suppression by symbiont of host immune response\" EXACT []" ], "previous": [ "\"down regulation by symbiont of host immune response\" EXACT []", "\"down-regulation by symbiont of host immune response\" EXACT []", "\"downregulation by symbiont of host immune response\" EXACT []", "\"inhibition by symbiont of host immune response\" NARROW []", "\"negative regulation by organism of immune response of other organism involved in symbiotic interaction\" BROAD []", "\"negative regulation by symbiont of host immune response\" EXACT []" ] } } }, { "id": "GO:0055062", "name": "phosphate ion homeostasis", "changes": { "synonyms": { "current": [ "\"phosphate homeostasis\" BROAD []", "\"Pi homeostasis\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0055086", "name": "nucleobase-containing small molecule metabolic process", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0060395", "name": "SMAD protein signal transduction", "changes": { "definition": { "current": "\"An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes.\" [GOC:BHF]", "previous": "\"An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes.\" [GOC:BHF]" } } }, { "id": "GO:0061024", "name": "membrane organization", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0062200", "name": "RAM/MOR signaling", "changes": { "name": { "current": "RAM/MOR signaling", "previous": "RAM/MOR signaling pathway" }, "definition": { "current": "\"An intracellular signaling cascade that starts with the activation of S. cerevisiae Kic1p, which activate Mob2p and Cbk1p. Cbk1p phosphorylates Ace2p, which results in its nuclear translocation, where it regulates transcription of genes involved in polarity and morphogenesis.\" [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372, PMID:23212898]", "previous": "\"An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase.\" [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372]" }, "synonyms": { "current": [ "\"MOR signaling pathway\" NARROW []", "\"morphogenesis Orb6 network\" EXACT []", "\"RAM signaling pathway\" NARROW []", "\"RAM/MOR signaling pathway\" EXACT []" ], "previous": [ "\"MOR signaling pathway\" NARROW []", "\"morphogenesis Orb6 network\" EXACT []", "\"RAM signaling pathway\" NARROW []" ] } } }, { "id": "GO:0065003", "name": "protein-containing complex assembly", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0070424", "name": "regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "changes": { "name": { "current": "regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "previous": "regulation of nucleotide-binding oligomerization domain containing signaling pathway" }, "definition": { "current": "\"Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.\" [GOC:add]", "previous": "\"Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway.\" [GOC:add]" }, "synonyms": { "current": [ "\"regulation of NOD signaling pathway\" NARROW [GOC:add]", "\"regulation of nucleotide-binding oligomerization domain containing signaling pathway\" NARROW []", "\"regulation of nucleotide-binding oligomerization domain containing signalling pathway\" NARROW [GOC:mah]" ], "previous": [ "\"regulation of NOD signaling pathway\" EXACT [GOC:add]", "\"regulation of nucleotide-binding oligomerization domain containing signalling pathway\" EXACT [GOC:mah]" ] } } }, { "id": "GO:0070425", "name": "negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "changes": { "name": { "current": "negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "previous": "negative regulation of nucleotide-binding oligomerization domain containing signaling pathway" }, "definition": { "current": "\"Any process that stops, prevents, or reduces the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.\" [GOC:add]", "previous": "\"Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway.\" [GOC:add]" }, "synonyms": { "current": [ "\"negative regulation of NOD signaling pathway\" NARROW [GOC:add]", "\"negative regulation of nucleotide-binding oligomerization domain containing signaling pathway\" NARROW []", "\"negative regulation of nucleotide-binding oligomerization domain containing signalling pathway\" NARROW [GOC:mah]" ], "previous": [ "\"negative regulation of NOD signaling pathway\" EXACT [GOC:add]", "\"negative regulation of nucleotide-binding oligomerization domain containing signalling pathway\" EXACT [GOC:mah]" ] } } }, { "id": "GO:0070426", "name": "positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "changes": { "name": { "current": "positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway", "previous": "positive regulation of nucleotide-binding oligomerization domain containing signaling pathway" }, "definition": { "current": "\"Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway.\" [GOC:add]", "previous": "\"Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway.\" [GOC:add]" }, "synonyms": { "current": [ "\"positive regulation of NOD signaling pathway\" NARROW [GOC:add]", "\"positive regulation of nucleotide-binding oligomerization domain containing signaling pathway\" NARROW []", "\"positive regulation of nucleotide-binding oligomerization domain containing signalling pathway\" NARROW [GOC:mah]" ], "previous": [ "\"positive regulation of NOD signaling pathway\" EXACT [GOC:add]", "\"positive regulation of nucleotide-binding oligomerization domain containing signalling pathway\" EXACT [GOC:mah]" ] } } }, { "id": "GO:0071554", "name": "cell wall organization or biogenesis", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_generic", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_pombe", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0071630", "name": "nuclear protein quality control by the ubiquitin-proteasome system", "changes": { "definition": { "current": "\"A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation.\" [PMID:20080635, PMID:21211726]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation.\" [GOC:mah, GOC:rb, PMID:20080635, PMID:21211726, PMID:21324894]" }, "comment": { "current": "N/A", "previous": "See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'." } } }, { "id": "GO:0071941", "name": "nitrogen cycle metabolic process", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0072657", "name": "protein localization to membrane", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0075109", "name": "symbiont-mediated perturbation of host receptor-mediated signal transduction", "changes": { "name": { "current": "symbiont-mediated perturbation of host receptor-mediated signal transduction", "previous": "perturbation of host receptor-mediated signal transduction" }, "definition": { "current": "\"A process by which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]", "previous": "\"A process in which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]" }, "comment": { "current": "N/A", "previous": "Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term \"modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078\"." }, "synonyms": { "current": [ "\"perturbation of host receptor-mediated signal transduction\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0075118", "name": "symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway", "changes": { "name": { "current": "symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway", "previous": "perturbation of host G protein-coupled receptor signal transduction pathway" }, "definition": { "current": "\"A process by which a symbiont alters or subverts the normal execution of a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]", "previous": "\"Any process in which the symbiont alters a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]" }, "comment": { "current": "N/A", "previous": "Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term \"modulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075087\"." }, "synonyms": { "current": [ "\"modulation by symbiont of host G protein-coupled receptor signal transduction\" EXACT []", "\"modulation by symbiont of host G-protein coupled receptor protein signal transduction\" EXACT []", "\"modulation by symbiont of host signal transduction mediated by G-protein alpha subunit\" NARROW []", "\"modulation by symbiont of host signal transduction mediated by G-protein beta subunit\" NARROW []", "\"modulation by symbiont of host signal transduction mediated by G-protein gamma subunit\" NARROW []", "\"perturbation of host G protein-coupled receptor signal transduction pathway\" EXACT []" ], "previous": [ "\"modulation by symbiont of host G protein-coupled receptor signal transduction\" EXACT []", "\"modulation by symbiont of host G-protein coupled receptor protein signal transduction\" EXACT []", "\"modulation by symbiont of host signal transduction mediated by G-protein alpha subunit\" NARROW []", "\"modulation by symbiont of host signal transduction mediated by G-protein beta subunit\" NARROW []", "\"modulation by symbiont of host signal transduction mediated by G-protein gamma subunit\" NARROW []" ] } } }, { "id": "GO:0075120", "name": "symbiont-mediated suppression of host G protein-coupled receptor signal transduction", "changes": { "comment": { "current": "N/A", "previous": "Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term \"negative regulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075089\"." } } }, { "id": "GO:0075133", "name": "symbiont-mediated perturbation of host calcium or calmodulin-mediated signal transduction", "changes": { "name": { "current": "symbiont-mediated perturbation of host calcium or calmodulin-mediated signal transduction", "previous": "perturbation of host calcium or calmodulin-mediated signal transduction" }, "comment": { "current": "N/A", "previous": "Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term \"modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103\"." }, "synonyms": { "current": [ "\"modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction\" EXACT []", "\"perturbation of host calcium or calmodulin-mediated signal transduction\" EXACT []" ], "previous": [ "\"modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction\" EXACT []" ] } } }, { "id": "GO:0075135", "name": "symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction", "changes": { "comment": { "current": "N/A", "previous": "Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term \"Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105\"." } } }, { "id": "GO:0085032", "name": "symbiont-mediated perturbation of host NF-kappaB cascade", "changes": { "name": { "current": "symbiont-mediated perturbation of host NF-kappaB cascade", "previous": "pertubation of host canonical NF-kappaB cascade" }, "definition": { "current": "\"A process in which a symbiont alters or subverts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]", "previous": "\"A process in which a symbiont alters or subverts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [GOC:pamgo_curators]" }, "synonyms": { "current": [ "\"modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"modulation by symbiont of host NF-kappaB-mediated signal transduction pathway\" RELATED []", "\"pertubation of host canonical NF-kappaB cascade\" RELATED []", "\"pertubation of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"symbiont-mediated pertubation of host canonical NF-kappaB cascade\" RELATED []", "\"symbiont-mediated perturbation of host canonical NF-kappaB cascade\" RELATED []" ], "previous": [ "\"modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"modulation by symbiont of host NF-kappaB-mediated signal transduction pathway\" EXACT []", "\"pertubation of host I-kappaB kinase/NF-kappaB cascade\" EXACT []" ] } } }, { "id": "GO:0085033", "name": "symbiont-mediated activation of host NF-kappaB signal transduction", "changes": { "name": { "current": "symbiont-mediated activation of host NF-kappaB signal transduction", "previous": "induction of host canonical NF-kappaB signal transduction" }, "definition": { "current": "\"A process that initiates, promotes, or enhances a host NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:11907233, PMID:17490702, PMID:21098302, PMID:21199955, PMID:31311877, PMID:7845680]", "previous": "\"A process that initiates, promotes, or enhances a canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:17490702, PMID:21098302, PMID:21199955, PMID:31311877]" }, "synonyms": { "current": [ "\"activation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"induction by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"induction of host canonical NF-kappaB signal transduction\" RELATED []", "\"induction of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway\" RELATED []", "\"stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"symbiont-mediated activation of host canonical NF-kappaB signal transduction\" RELATED []", "\"up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []" ], "previous": [ "\"activation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"induction by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"induction of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway\" EXACT []", "\"positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway\" EXACT []", "\"stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []" ] } } }, { "id": "GO:0085034", "name": "symbiont-mediated suppression of host NF-kappaB cascade", "changes": { "name": { "current": "symbiont-mediated suppression of host NF-kappaB cascade", "previous": "symbiont-mediated suppression of host canonical NF-kappaB cascade" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:18250452, PMID:22442494, PMID:24648522, PMID:33567255]", "previous": "\"A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:18250452, PMID:22442494, PMID:24648522, PMID:33567255]" }, "synonyms": { "current": [ "\"disruption of host canonical NF-kappaB cascade\" RELATED []", "\"disruption of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade\" RELATED []", "\"symbiont-mediated suppression of host canonical NF-kappaB cascade\" RELATED []" ], "previous": [ "\"disruption of host canonical NF-kappaB cascade\" EXACT []", "\"disruption of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []", "\"suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade\" EXACT []" ] } } }, { "id": "GO:0098003", "name": "viral tail assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of a set of components to form a virus tail.\" [GOC:bm, VZ:3955]", "previous": "\"The aggregation, arrangement and bonding together of a set of components to form a virus tail.\" [GOC:bm]" } } }, { "id": "GO:0098004", "name": "virus tail fiber assembly", "changes": { "definition": { "current": "\"The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber.\" [GOC:bm, VZ:3956]", "previous": "\"The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber.\" [GOC:bm]" } } }, { "id": "GO:0098542", "name": "defense response to other organism", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0098672", "name": "suppression of host CRISPR-cas system", "changes": { "name": { "current": "suppression of host CRISPR-cas system", "previous": "inhibition of host CRISPR-cas system by virus" }, "definition": { "current": "\"A process by which a symbiont interferes with, inhibits or disrupts the CRISPR-cas system of its host. Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infection by bacteriophages (phages), and phages have various mechanisms to counter the CRISPR-cas system.\" [PMID:23242138, PMID:23446421, PMID:26416740, PMID:28749735]", "previous": "\"A process by which a virus inhibits the CRISPR-cas system of its host.\" [PMID:23242138, PMID:23446421, PMID:26416740, PMID:28749735]" }, "synonyms": { "current": [ "\"anti-CRISPR\" BROAD []", "\"CRISPR-cas system evasion by virus\" EXACT [VZ:3962]", "\"evasion by virus of CRISPR-cas system\" RELATED []", "\"inhibition of host CRISPR-cas system by virus\" RELATED []" ], "previous": [ "\"anti-CRISPR\" BROAD []", "\"CRISPR-cas system evasion by virus\" EXACT [VZ:3962]", "\"evasion by virus of CRISPR-cas system\" RELATED []" ] } } }, { "id": "GO:0098677", "name": "virion maturation", "changes": { "definition": { "current": "\"Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection.\" [ISBN:0781718325, VZ:1946]", "previous": "\"Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection.\" [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946]" } } }, { "id": "GO:0098754", "name": "detoxification", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_generic", "goslim_pombe", "prokaryote_subset" ] } } }, { "id": "GO:0098932", "name": "symbiont entry into host cell via disruption of host cell wall peptidoglycan", "changes": { "name": { "current": "symbiont entry into host cell via disruption of host cell wall peptidoglycan", "previous": "disruption by virus of host cell wall peptidoglycan during virus entry" }, "definition": { "current": "\"The disruption by a symbiont of host cell wall peptidoglycans to allow entry into the host cell.\" [GOC:dos, VZ:3940]", "previous": "\"A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry.\" [GOC:dos, VZ:3940]" }, "synonyms": { "current": [ "\"catabolism of host cell wall peptidoglycan by virus\" EXACT []", "\"degradation of host cell wall peptidoglycan by virus\" EXACT []", "\"degradation of host peptidoglycans during virus entry\" EXACT [VZ:3940]", "\"disassembly by virus of host cell wall peptidoglycan\" EXACT []", "\"disruption by virus of host cell wall peptidoglycan during virus entry\" EXACT []" ], "previous": [ "\"catabolism of host cell wall peptidoglycan by virus\" EXACT []", "\"degradation of host cell wall peptidoglycan by virus\" EXACT []", "\"degradation of host peptidoglycans during virus entry\" EXACT [VZ:3940]", "\"disassembly by virus of host cell wall peptidoglycan\" EXACT []" ] } } }, { "id": "GO:0098994", "name": "symbiont entry into host cell via disruption of host cell envelope", "changes": { "name": { "current": "symbiont entry into host cell via disruption of host cell envelope", "previous": "disruption of host cell envelope during viral entry" }, "definition": { "current": "\"The disruption by a symbiont of host cell envelope components to allow entry into the host cell.\" [GOC:dos]", "previous": "\"The disruption of host cell envelope by viral proteins during virus entry.\" [GOC:dos]" }, "synonyms": { "current": [ "\"disruption of host cell envelope during viral entry\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0098995", "name": "symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide", "changes": { "name": { "current": "symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide", "previous": "disruption by virus of host envelope lipopolysaccharide during virus entry" }, "definition": { "current": "\"The disruption by a symbiont of host cell wall lipopolysaccharides to allow entry into the host cell. For example a phage entering a Gram-negative bacterium may actively break down outer membrane lipopolysaccharides.\" [GOC:dos, VZ:3940]", "previous": "\"The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides.\" [GOC:dos, VZ:3940]" }, "synonyms": { "current": [ "\"degradation of host cell envelope lipopolysaccharide during viral entry\" EXACT []", "\"degradation of host lipopolysaccharide during virus entry\" EXACT [VZ:3940]", "\"disassembly by virus of outer membrane lipopolysaccharide during viral entry\" NARROW []", "\"disruption by virus of host envelope lipopolysaccharide during virus entry\" EXACT []" ], "previous": [ "\"degradation of host cell envelope lipopolysaccharide during viral entry\" EXACT []", "\"degradation of host lipopolysaccharide during virus entry\" EXACT [VZ:3940]", "\"disassembly by virus of outer membrane lipopolysaccharide during viral entry\" NARROW []" ] } } }, { "id": "GO:0098996", "name": "symbiont entry into host cell via disruption of host cell glycocalyx", "changes": { "name": { "current": "symbiont entry into host cell via disruption of host cell glycocalyx", "previous": "disruption of host cell glycocalyx during viral entry" }, "definition": { "current": "\"The disruption by a symbiont of host cell capsule to allow entry into the host cell.\" [GOC:dos]", "previous": "\"The disruption of host cell glycocalyx by viral proteins during virus entry.\" [GOC:dos]" }, "synonyms": { "current": [ "\"catabolism of host glycocalyx during viral entry\" EXACT []", "\"degradation of host capsule during virus entry\" EXACT [VZ:3896]", "\"degradation of host glycocalyx during viral entry\" EXACT []", "\"disassembly of glycocalyx during viral entry\" EXACT []", "\"disruption of host cell glycocalyx during viral entry\" EXACT []", "\"symbiont entry into host cell by disruption of host cell capsule\" EXACT []" ], "previous": [ "\"catabolism of host glycocalyx during viral entry\" EXACT []", "\"degradation of host capsule during virus entry\" EXACT [VZ:3896]", "\"degradation of host glycocalyx during viral entry\" EXACT []", "\"disassembly of glycocalyx during viral entry\" EXACT []" ] } } }, { "id": "GO:0099000", "name": "symbiont genome ejection through host cell envelope, contractile tail mechanism", "changes": { "name": { "current": "symbiont genome ejection through host cell envelope, contractile tail mechanism", "previous": "viral genome ejection through host cell envelope, contractile tail mechanism" }, "definition": { "current": "\"Entry of a symbiont's genome into the host cell through the host cell envelope via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. Occurs in non-enveloped prokaryotic viruses.\" [GOC:dos, PMID:26283379, VZ:3950]", "previous": "\"Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope.\" [GOC:dos, PMID:26283379, VZ:3950]" }, "synonyms": { "current": [ "\"viral contractile tail ejection system\" EXACT [VZ:3950]", "\"viral genome ejection through host cell envelope, contractile tail mechanism\" RELATED []" ], "previous": [ "\"viral contractile tail ejection system\" EXACT [VZ:3950]" ] } } }, { "id": "GO:0099001", "name": "symbiont genome ejection through host cell envelope, long flexible tail mechanism", "changes": { "name": { "current": "symbiont genome ejection through host cell envelope, long flexible tail mechanism", "previous": "viral genome ejection through host cell envelope, long flexible tail mechanism" }, "definition": { "current": "\"Entry of a symbiont's genome into the host cell through the host cell envelope via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. Occurs in non-enveloped prokaryotic viruses.\" [GOC:dos, PMID:22297512, VZ:3952]", "previous": "\"Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm.\" [GOC:dos, PMID:22297512, VZ:3952]" }, "synonyms": { "current": [ "\"viral genome ejection through host cell envelope, long flexible tail mechanism\" RELATED []", "\"viral long flexible tail ejection system\" EXACT [VZ:3952]" ], "previous": [ "\"viral long flexible tail ejection system\" EXACT [VZ:3952]" ] } } }, { "id": "GO:0099002", "name": "symbiont genome ejection through host cell envelope, short tail mechanism", "changes": { "name": { "current": "symbiont genome ejection through host cell envelope, short tail mechanism", "previous": "viral genome ejection through host cell envelope, short tail mechanism" }, "definition": { "current": "\"Entry of a symbiont's genome into the host cell through the host cell envelope via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. Occurs in non-enveloped prokaryotic viruses.\" [GOC:dos, PMID:22297513, VZ:3954]", "previous": "\"Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties.\" [GOC:dos, PMID:22297513, VZ:3954]" }, "synonyms": { "current": [ "\"viral genome ejection through host cell envelope, short tail mechanism\" RELATED []", "\"viral short tail ejection system\" EXACT [VZ:3954]" ], "previous": [ "\"viral short tail ejection system\" EXACT [VZ:3954]" ] } } }, { "id": "GO:0099006", "name": "symbiont entry into host cell via permeabilization of endosomal membrane", "changes": { "name": { "current": "symbiont entry into host cell via permeabilization of endosomal membrane", "previous": "viral entry via permeabilization of endosomal membrane" }, "definition": { "current": "\"The entry of a symbiont into a host cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) of the symbiont. This process mediates the entry of some non-enveloped virus into eukaryotic cells. In some cases, viral membrane-penetration protein requires to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen.\" [PMID:15329727, PMID:25055856]", "previous": "\"The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen.\" [PMID:15329727, PMID:25055856, VZ:985]" }, "synonyms": { "current": [ "\"viral entry via permeabilization of endosomal membrane\" NARROW []" ], "previous": [ "\"viral penetration via permeabilization of host membrane\" BROAD [vz:985]" ] } } }, { "id": "GO:0099008", "name": "symbiont entry into host cell via permeabilization of inner membrane", "changes": { "name": { "current": "symbiont entry into host cell via permeabilization of inner membrane", "previous": "viral entry via permeabilization of inner membrane" }, "definition": { "current": "\"The entry of a symbiont into the cytoplasm of a host cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. This process mediates the entry of some non-enveloped viruses into prokaryotic cells. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization and permeabilization of the plasma membrane.\" [PMID:15795287, PMID:20427561]", "previous": "\"The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane.\" [PMID:15795287, PMID:20427561, VZ:985]" }, "synonyms": { "current": [ "\"viral entry via permeabilization of inner membrane\" NARROW []" ], "previous": [ "\"viral penetration via permeabilization of host membrane\" BROAD [vz:985]" ] } } }, { "id": "GO:0099016", "name": "evasion of DNA end degradation by host", "changes": { "name": { "current": "evasion of DNA end degradation by host", "previous": "evasion by virus of DNA end degradation" }, "definition": { "current": "\"A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases.\" [GOC:dos, PMID:11894948, PMID:16949369, VZ:3963]", "previous": "\"A process by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases.\" [GOC:dos]" }, "synonyms": { "current": [ "\"DNA end degradation evasion by virus\" EXACT []", "\"evasion by virus of DNA end degradation\" RELATED []" ], "previous": [ "\"DNA end degradation evasion by virus\" EXACT []" ] } } }, { "id": "GO:0099018", "name": "evasion of host restriction-modification system", "changes": { "name": { "current": "evasion of host restriction-modification system", "previous": "evasion by virus of host restriction-modification system" }, "definition": { "current": "\"A process by which a symbiont evades the DNA restriction modification system of its host. This process occurs in phages to protein themselves from bacterial restriction enzyme systems. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction.\" [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966]", "previous": "\"Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction.\" [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966]" }, "synonyms": { "current": [ "\"evasion by virus of host restriction-modification system\" RELATED []", "\"restriction-modification system evasion by virus\" EXACT []" ], "previous": [ "\"restriction-modification system evasion by virus\" EXACT []" ] } } }, { "id": "GO:0140133", "name": "symbiont-mediated suppression of host cytokine production", "changes": { "name": { "current": "symbiont-mediated suppression of host cytokine production", "previous": "suppression by symbiont of host cytokine production" }, "definition": { "current": "\"A process by which a symbiont inhibits or disrupts the normal rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:23083102]", "previous": "\"Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:23083102]" }, "synonyms": { "current": [ "\"negative regulation by symbiont of host cytokine production\" EXACT []", "\"suppression by symbiont of host cytokine production\" EXACT []", "\"suppression by symbiont of host cytokine secretion\" RELATED []" ], "previous": [ "\"negative regulation by symbiont of host cytokine production\" EXACT []", "\"suppression by symbiont of host cytokine secretion\" RELATED []" ] } } }, { "id": "GO:0140267", "name": "symbiont entry into host cell via permeabilization of host membrane", "changes": { "name": { "current": "symbiont entry into host cell via permeabilization of host membrane", "previous": "viral entry via permeabilization of host membrane" }, "definition": { "current": "\"The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm.\" [PMID:20427561, PMID:25055856, VZ:985]", "previous": "\"The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm.\" [PMID:20427561, PMID:25055856]" }, "synonyms": { "current": [ "\"viral entry via permeabilization of host membrane\" NARROW []" ], "previous": "N/A" }, "subsets": { "current": "N/A", "previous": [ "gocheck_do_not_annotate" ] } } }, { "id": "GO:0140493", "name": "very long-chain fatty acid beta-oxidation", "changes": { "definition": { "current": "\"A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:ha, PMID:17028011, PMID:32169171]", "previous": "\"A fatty acid beta-oxidation pathway acting on a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).\" [GOC:ha, PMID:17028011, PMID:32169171]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0140546", "name": "defense response to symbiont", "changes": { "definition": { "current": "\"Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host.\" [GOC:pg]", "previous": "\"Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont.\" [GOC:pg]" } } }, { "id": "GO:0140884", "name": "symbiont-mediated suppression of host type II interferon-mediated signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of host type II interferon-mediated signaling pathway", "previous": "suppression by virus of host type II interferon-mediated signaling pathway" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma.\" [PMID:28901902]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma.\" [PMID:28901902]" }, "synonyms": { "current": [ "\"negative regulation by virus of host type II interferon-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type II IFN-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type II interferon-mediated signaling pathway\" NARROW []", "\"suppression by virus of host type II interferon-mediated signalling pathway\" EXACT []" ], "previous": [ "\"negative regulation by virus of host type II interferon-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type II IFN-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type II interferon-mediated signalling pathway\" EXACT []" ] } } }, { "id": "GO:0140885", "name": "symbiont-mediated suppression of host type III interferon-mediated signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of host type III interferon-mediated signaling pathway", "previous": "suppression by virus of host type III interferon-mediated signaling pathway" }, "definition": { "current": "\"A process in which a symbiont interferes with, inhibits or disrupts a type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda.\" [PMID:32464097]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda.\" [PMID:32464097]" }, "synonyms": { "current": [ "\"negative regulation by virus of host type III interferon-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type III IFN-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type III interferon-mediated signaling pathway\" NARROW []", "\"suppression by virus of host type III interferon-mediated signalling pathway\" EXACT []" ], "previous": [ "\"negative regulation by virus of host type III interferon-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type III IFN-mediated signaling pathway\" EXACT []", "\"suppression by virus of host type III interferon-mediated signalling pathway\" EXACT []" ] } } }, { "id": "GO:0140886", "name": "symbiont-mediated suppression of host interferon-mediated signaling pathway", "changes": { "name": { "current": "symbiont-mediated suppression of host interferon-mediated signaling pathway", "previous": "suppression by virus of host interferon-mediated signaling pathway" }, "definition": { "current": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism.\" [PMID:31266861, PMID:33097660, PMID:34305858]", "previous": "\"Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism.\" [PMID:33097660]" }, "synonyms": { "current": [ "\"inhibition of host interferon signaling pathway by symbiont\" RELATED []", "\"negative regulation by virus of host interferon-mediated signaling pathway\" NARROW []", "\"suppression by symbiont of host IFN-mediated signaling pathway\" EXACT []", "\"suppression by symbiont of host interferon-mediated signalling pathway\" EXACT []", "\"suppression by virus of host interferon-mediated signaling pathway\" NARROW []" ], "previous": [ "\"inhibition of host interferon signaling pathway by virus\" RELATED []", "\"negative regulation by virus of host interferon-mediated signaling pathway\" EXACT []", "\"suppression by virus of host IFN-mediated signaling pathway\" EXACT []", "\"suppression by virus of host interferon-mediated signalling pathway\" EXACT []" ] } } }, { "id": "GO:0140986", "name": "G protein-coupled chemorepellent receptor signaling pathway", "changes": { "definition": { "current": "\"A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization.\" [PMID:30462573]", "previous": "\"A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization.\" [PMID:30462573]" } } }, { "id": "GO:0141062", "name": "disruption of tissue in another organism", "changes": { "definition": { "current": "\"The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue.\" [PMID:11895956, PMID:26355030, PMID:27416066, PMID:28194160, PMID:34346770]", "previous": "\"The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue.\" [PMID:11895956, PMID:26355030, PMID:27416066, PMID:34346770]" }, "synonyms": { "current": [ "\"tissue necrosis in another organism\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0141070", "name": "symbiont-mediated suppression of host MAPK cascade", "changes": { "name": { "current": "symbiont-mediated suppression of host MAPK cascade", "previous": "symbiont-mediated suppression of host MAPK signal transduction pathway" }, "synonyms": { "current": [ "\"disruption of host MAP kinase signaling pathway\" EXACT []", "\"disruption of host MAPK signal transduction pathway\" EXACT []", "\"disruption of host MAPK signaling pathway\" EXACT []", "\"symbiont-mediated suppression of host MAPK signal transduction pathway\" EXACT []" ], "previous": [ "\"disruption of host MAP kinase signaling pathway\" EXACT []", "\"disruption of host MAPK signal transduction pathway\" EXACT []", "\"disruption of host MAPK signaling pathway\" EXACT []" ] } } }, { "id": "GO:0141071", "name": "symbiont-mediated activation of host MAPK cascade", "changes": { "name": { "current": "symbiont-mediated activation of host MAPK cascade", "previous": "symbiont-mediated activation of host MAPK signal transduction pathway" }, "synonyms": { "current": [ "\"activation by symbiont of host MAPK signal transduction pathway\" NARROW []", "\"induction by symbiont of host MAP kinase signal transduction pathway\" EXACT []", "\"induction of host MAPK kinase signaling pathway\" EXACT []", "\"stimulation by symbiont of host MAPK signal transduction pathway\" NARROW []", "\"symbiont-mediated activation of host MAPK signal transduction pathway\" EXACT []" ], "previous": [ "\"activation by symbiont of host MAPK signal transduction pathway\" NARROW []", "\"induction by symbiont of host MAP kinase signal transduction pathway\" EXACT []", "\"induction of host MAPK kinase signaling pathway\" EXACT []", "\"stimulation by symbiont of host MAPK signal transduction pathway\" NARROW []" ] } } }, { "id": "GO:0141104", "name": "symbiont-mediated activation of host G protein-coupled receptor signal transduction", "changes": { "definition": { "current": "\"A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:15963708, PMID:18978047, PMID:25332123]", "previous": "\"A process in which a symbiont G protein-coupled receptor signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction.\" [PMID:15963708, PMID:18978047, PMID:25332123]" } } }, { "id": "GO:1901135", "name": "carbohydrate derivative metabolic process", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_generic", "goslim_mouse", "goslim_prokaryote" ], "previous": [ "goslim_agr", "goslim_generic", "goslim_mouse", "prokaryote_subset" ] } } }, { "id": "GO:1990983", "name": "regulation of translational initiation by tRNA modification", "changes": { "name": { "current": "regulation of translational initiation by tRNA modification", "previous": "tRNA demethylation" }, "definition": { "current": "\"A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule.\" [PMID:27745969]", "previous": "\"The removal of a methyl group from one or more residues within a tRNA molecule.\" [PMID:27745969]" }, "synonyms": { "current": [ "\"tRNA demethylation\" BROAD []" ], "previous": "N/A" } } } ], "molecular_function": [ { "id": "GO:0003677", "name": "DNA binding", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0003723", "name": "RNA binding", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0003774", "name": "cytoskeletal motor activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_generic", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_generic", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0003924", "name": "GTPase activity", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0003953", "name": "NAD+ nucleosidase activity", "changes": { "synonyms": { "current": [ "\"beta-NAD(+) glycohydrolase activity\" EXACT []", "\"diphosphopyridine nucleosidase activity\" EXACT []", "\"DPNase activity\" EXACT []", "\"NAD glycohydrolase activity\" EXACT []", "\"NAD nucleosidase activity\" EXACT []", "\"NAD(+) glycohydrolase activity\" EXACT []", "\"NADase activity\" EXACT []", "\"nicotinamide adenine dinucleotide glycohydrolase activity\" EXACT []", "\"nicotinamide adenine dinucleotide nucleosidase activity\" EXACT []" ], "previous": [ "\"NAD nucleosidase activity\" EXACT []" ] } } }, { "id": "GO:0004085", "name": "butyryl-CoA dehydrogenase activity", "changes": { "synonyms": { "current": "N/A", "previous": [ "\"3-hydroxyacyl CoA reductase activity\" RELATED [EC:1.3.8.1]", "\"butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity\" RELATED [EC:1.3.8.1]", "\"butanoyl-CoA:acceptor 2,3-oxidoreductase activity\" RELATED [EC:1.3.8.1]", "\"butyryl coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.1]", "\"butyryl dehydrogenase activity\" RELATED [EC:1.3.8.1]", "\"enoyl-coenzyme A reductase activity\" RELATED [EC:1.3.8.1]", "\"ethylene reductase activity\" RELATED [EC:1.3.8.1]", "\"short-chain acyl CoA dehydrogenase activity\" RELATED [EC:1.3.8.1]", "\"short-chain acyl-coenzyme A dehydrogenase activity\" RELATED [EC:1.3.8.1]", "\"short-chain-acyl-CoA dehydrogenase activity\" RELATED [EC:1.3.8.1]", "\"unsaturated acyl coenzyme A reductase activity\" RELATED [EC:1.3.8.1]", "\"unsaturated acyl-CoA reductase activity\" RELATED [EC:1.3.8.1]" ] } } }, { "id": "GO:0004164", "name": "diphthine synthase activity", "changes": { "comment": { "current": "This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note tha this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which produces diphthine methyl ester.", "previous": "N/A" } } }, { "id": "GO:0004317", "name": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "name": { "current": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "previous": "(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" }, "synonyms": { "current": [ "\"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)\" EXACT []", "\"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity\" EXACT []", "\"(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-ACP dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity\" EXACT []" ], "previous": [ "\"(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity\" RELATED []", "\"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)\" EXACT []", "\"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity\" EXACT []", "\"3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity\" RELATED []", "\"3-hydroxypalmitoyl-ACP dehydratase activity\" EXACT []", "\"3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity\" EXACT []" ] } } }, { "id": "GO:0004361", "name": "glutaryl-CoA dehydrogenase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction", "previous": "\"3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].\" [RHEA:13389]" } } }, { "id": "GO:0004467", "name": "long-chain fatty acid-CoA ligase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). Note that this term has a MetaCyc pathway reference as the pathway only has a single step.", "previous": "Note that this term has a MetaCyc pathway reference as the pathway only has a single step." } } }, { "id": "GO:0004794", "name": "threonine deaminase activity", "changes": { "name": { "current": "threonine deaminase activity", "previous": "L-threonine ammonia-lyase activity" }, "comment": { "current": "N/A", "previous": "Note that this function was formerly EC:4.2.1.16." }, "synonyms": { "current": [ "\"L-serine dehydratase activity\" RELATED [EC:4.3.1.19]", "\"L-threonine ammonia-lyase (2-oxobutanoate-forming)\" EXACT [EC:4.3.1.19]", "\"L-threonine ammonia-lyase activity\" EXACT []", "\"L-threonine deaminase activity\" EXACT [EC:4.3.1.19]", "\"L-threonine dehydratase activity\" EXACT [EC:4.3.1.19]", "\"L-threonine hydro-lyase (deaminating) activity\" RELATED [EC:4.3.1.19]", "\"serine deaminase activity\" RELATED [EC:4.3.1.19]", "\"threonine ammonia-lyase activity\" BROAD []", "\"threonine dehydrase activity\" EXACT [EC:4.3.1.19]", "\"threonine dehydratase activity\" BROAD []" ], "previous": [ "\"L-serine dehydratase activity\" RELATED [EC:4.3.1.19]", "\"L-threonine ammonia-lyase (2-oxobutanoate-forming)\" RELATED [EC:4.3.1.19]", "\"L-threonine deaminase activity\" RELATED [EC:4.3.1.19]", "\"L-threonine dehydratase activity\" RELATED [EC:4.3.1.19]", "\"L-threonine hydro-lyase (deaminating) activity\" RELATED [EC:4.3.1.19]", "\"serine deaminase activity\" RELATED [EC:4.3.1.19]", "\"threonine ammonia-lyase activity\" EXACT []", "\"threonine deaminase activity\" RELATED [EC:4.3.1.19]", "\"threonine dehydrase activity\" RELATED [EC:4.3.1.19]", "\"threonine dehydratase activity\" EXACT []" ] } } }, { "id": "GO:0004848", "name": "ureidoglycolate hydrolase activity", "changes": { "comment": { "current": "Take care to annotate to the reaction, not simply the enzyme name. The name \"ureidoglycolate hydrolase\" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The \"ureidoglycolate hydrolase\" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.1.116, GO:0004848). The \"ureidoglycolate hydrolase\" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.1.116) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.1.116 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.", "previous": "Take care to annotate to the reaction, not simply the enzyme name. The name \"ureidoglycolate hydrolase\" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The \"ureidoglycolate hydrolase\" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19, GO:0004848). The \"ureidoglycolate hydrolase\" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name." }, "synonyms": { "current": [ "\"ureidoglycolate amidohydrolase activity\" EXACT []" ], "previous": [ "\"(S)-ureidoglycolate amidohydrolase (decarboxylating)\" EXACT []" ] } } }, { "id": "GO:0005198", "name": "structural molecule activity", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005215", "name": "transporter activity", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_annotate", "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0005324", "name": "long-chain fatty acid transporter activity", "changes": { "definition": { "current": "\"Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [ISBN:0198506732]", "previous": "\"Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [ISBN:0198506732]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0008092", "name": "cytoskeletal protein binding", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0008177", "name": "succinate dehydrogenase (quinone) activity", "changes": { "name": { "current": "succinate dehydrogenase (quinone) activity", "previous": "succinate dehydrogenase (ubiquinone) activity" }, "synonyms": { "current": [ "\"fumarate reductase (menaquinone)\" NARROW []", "\"succinate dehydrogenase (menaquinone)\" NARROW []", "\"succinate dehydrogenase (ubiquinone) activity\" NARROW []", "\"succinic dehydrogenase activity\" BROAD [EC:1.3.5.1]" ], "previous": [ "\"succinate:ubiquinone oxidoreductase activity\" RELATED [EC:1.3.5.1]", "\"succinic dehydrogenase activity\" BROAD [EC:1.3.5.1]" ] } } }, { "id": "GO:0008289", "name": "lipid binding", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0008425", "name": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "changes": { "comment": { "current": "Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.", "previous": "N/A" } } }, { "id": "GO:0008659", "name": "(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "name": { "current": "(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "previous": "(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" }, "synonyms": { "current": [ "\"(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity\" EXACT []", "\"(3R)-hydroxymyristoyl-ACP dehydratase activity\" EXACT []" ], "previous": [ "\"(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"(3R)-hydroxymyristoyl-ACP dehydratase activity\" EXACT []" ] } } }, { "id": "GO:0008693", "name": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "synonyms": { "current": [ "\"(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity\" EXACT []", "\"3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-ACP dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-acyl carrier protein dehydrase activity\" EXACT []", "\"3-hydroxydecanoyl-acyl carrier protein dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity\" EXACT []", "\"beta-hydroxyacyl-ACP dehydrase activity\" EXACT []", "\"beta-hydroxyacyl-acyl carrier protein dehydratase activity\" EXACT []", "\"beta-hydroxydecanoate dehydrase activity\" EXACT []", "\"beta-hydroxydecanoyl thioester dehydrase activity\" EXACT []" ], "previous": [ "\"(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity\" RELATED []", "\"3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity\" BROAD []", "\"3-hydroxydecanoyl-ACP dehydratase activity\" EXACT []", "\"3-hydroxydecanoyl-acyl carrier protein dehydrase activity\" RELATED []", "\"3-hydroxydecanoyl-acyl carrier protein dehydratase activity\" RELATED []", "\"3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity\" RELATED []", "\"beta-hydroxyacyl-ACP dehydrase activity\" RELATED []", "\"beta-hydroxyacyl-acyl carrier protein dehydratase activity\" RELATED []", "\"beta-hydroxydecanoate dehydrase activity\" RELATED []", "\"beta-hydroxydecanoyl thioester dehydrase activity\" RELATED []" ] } } }, { "id": "GO:0008922", "name": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0008941", "name": "nitric oxide dioxygenase NAD(P)H activity", "changes": { "name": { "current": "nitric oxide dioxygenase NAD(P)H activity", "previous": "nitric oxide dioxygenase activity" }, "comment": { "current": "Note that this activity is similar to nitric oxide dioxygenase activity, heme protein ; GO:0141118, but GO:0141118 uses a heme protein as the electron donor.", "previous": "N/A" }, "synonyms": { "current": [ "\"nitric oxide dioxygenase activity\" BROAD []", "\"NOD activity\" RELATED [EC:1.14.12.17]" ], "previous": [ "\"nitric oxide,NAD(P)H:oxygen oxidoreductase activity\" RELATED [EC:1.14.12.17]", "\"NOD activity\" RELATED [EC:1.14.12.17]" ] } } }, { "id": "GO:0008942", "name": "nitrite reductase [NAD(P)H] activity", "changes": { "comment": { "current": "N/A", "previous": "Note that this function was formerly EC:1.6.6.4." } } }, { "id": "GO:0009055", "name": "electron transfer activity", "changes": { "definition": { "current": "\"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.\" [Wikipedia:Electron_transfer]", "previous": "\"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.\" [ISBN:0198506732]" }, "comment": { "current": "N/A", "previous": "Note that this term should only be be used for electron transfer that generates a transmembrane electrochemical gradient, e.g. components of the respiratory or photosynthetic electron transport chain." } } }, { "id": "GO:0009975", "name": "cyclase activity", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0010420", "name": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "changes": { "comment": { "current": "Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.", "previous": "N/A" } } }, { "id": "GO:0015483", "name": "long-chain fatty acid transporting porin activity", "changes": { "definition": { "current": "\"Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.\" [GOC:mtg_transport, TC:1.B.9.1.1]", "previous": "\"Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.\" [GOC:mtg_transport, TC:1.B.9.1.1]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0015636", "name": "short-chain fatty acid transmembrane transporter activity", "changes": { "definition": { "current": "\"Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.\" [GOC:mah]", "previous": "\"Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons.\" [GOC:mah]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0016209", "name": "antioxidant activity", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_generic", "goslim_metagenomics", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0016289", "name": "acyl-CoA hydrolase activity", "changes": { "name": { "current": "acyl-CoA hydrolase activity", "previous": "CoA hydrolase activity" }, "synonyms": { "current": [ "\"CoA hydrolase activity\" BROAD []" ], "previous": "N/A" } } }, { "id": "GO:0016438", "name": "tRNA-queuosine(34) beta-mannosyltransferase activity", "changes": { "name": { "current": "tRNA-queuosine(34) beta-mannosyltransferase activity", "previous": "tRNA-queuosine beta-mannosyltransferase activity" }, "synonyms": { "current": [ "\"GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity\" RELATED [EC:2.4.1.110]", "\"tRNA-queuosine beta-mannosyltransferase activity\" BROAD []" ], "previous": [ "\"GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity\" RELATED [EC:2.4.1.110]" ] } } }, { "id": "GO:0016491", "name": "oxidoreductase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016509", "name": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'." } } }, { "id": "GO:0016740", "name": "transferase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016787", "name": "hydrolase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016829", "name": "lyase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016853", "name": "isomerase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016874", "name": "ligase activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0016937", "name": "short-chain fatty acyl-CoA dehydrogenase activity", "changes": { "name": { "current": "short-chain fatty acyl-CoA dehydrogenase activity", "previous": "short-chain-acyl-CoA dehydrogenase activity" }, "synonyms": { "current": [ "\"butanoyl-CoA dehydrogenase\" NARROW [EC:1.3.8.1]", "\"butyryl dehydrogenase\" NARROW [EC:1.3.8.1]", "\"short-chain acyl CoA dehydrogenase\" EXACT [EC:1.3.8.1]", "\"short-chain-acyl-CoA dehydrogenase activity\" EXACT []", "\"unsaturated acyl-CoA reductase\" BROAD [EC:1.3.8.1]" ], "previous": "N/A" } } }, { "id": "GO:0017099", "name": "very-long-chain fatty acyl-CoA dehydrogenase activity", "changes": { "name": { "current": "very-long-chain fatty acyl-CoA dehydrogenase activity", "previous": "very-long-chain-acyl-CoA dehydrogenase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" }, "synonyms": { "current": [ "\"very long-chain-acyl-CoA dehydrogenase activity\" EXACT []", "\"very-long-chain acyl-CoA dehydrogenase activity\" EXACT []" ], "previous": [ "\"very long-chain-acyl-CoA dehydrogenase activity\" EXACT []" ] } } }, { "id": "GO:0018814", "name": "phenylacetaldoxime dehydratase activity", "changes": { "synonyms": { "current": [ "\"(Z)-phenylacetaldehyde-oxime hydro-lyase activity\" EXACT [EC:4.8.1.4]", "\"arylacetaldoxime dehydratase activity\" EXACT [EC:4.8.1.4]", "\"PAOx dehydratase activity\" RELATED [EC:4.8.1.4]" ], "previous": [ "\"(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity\" RELATED [EC:4.99.1.7]", "\"(Z)-phenylacetaldehyde-oxime hydro-lyase activity\" RELATED [EC:4.99.1.7]", "\"arylacetaldoxime dehydratase activity\" RELATED [EC:4.99.1.7]", "\"OxdB\" RELATED [EC:4.99.1.7]", "\"PAOx dehydratase activity\" RELATED [EC:4.99.1.7]" ] } } }, { "id": "GO:0031386", "name": "protein tag activity", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0031955", "name": "short-chain fatty acid-CoA ligase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0031956", "name": "medium-chain fatty acid-CoA ligase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0031957", "name": "very long-chain fatty acid-CoA ligase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0034013", "name": "aliphatic aldoxime dehydratase activity", "changes": { "synonyms": { "current": [ "\"aliphatic aldoxime hydro-lyase activity\" EXACT [EC:4.8.1.2]" ], "previous": [ "\"aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity\" RELATED [EC:4.99.1.5]", "\"aliphatic aldoxime hydro-lyase activity\" RELATED [EC:4.99.1.5]", "\"OxdA\" RELATED [EC:4.99.1.5]" ] } } }, { "id": "GO:0035380", "name": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0035516", "name": "broad specificity oxidative DNA demethylase activity", "changes": { "name": { "current": "broad specificity oxidative DNA demethylase activity", "previous": "oxidative DNA demethylase activity" }, "comment": { "current": "This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system.", "previous": "N/A" }, "synonyms": { "current": [ "\"1-ethyladenine demethylase activity\" NARROW []", "\"2-oxoglutarate-dependent DNA demethylase\" EXACT [PMID:17991826]", "\"5-formylcytosine dioxygenase activity\" NARROW []", "\"5-hydroxymethylcytosine dioxygenase activity\" NARROW []", "\"5fC dioxygenase\" NARROW []", "\"5hmC dioxygenase\" NARROW []", "\"N1-methyladenine demethylase activity\" NARROW []", "\"N3-methylcytosine demethylase activity\" NARROW []", "\"oxidative DNA demethylase activity\" BROAD []" ], "previous": [ "\"1-ethyladenine demethylase activity\" NARROW []", "\"2-oxoglutarate-dependent DNA demethylase\" EXACT [PMID:17991826]", "\"N1-methyladenine demethylase activity\" NARROW []", "\"N3-methylcytosine demethylase activity\" NARROW []" ] } } }, { "id": "GO:0036041", "name": "long-chain fatty acid binding", "changes": { "definition": { "current": "\"Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:pm, PMID:12641450]", "previous": "\"Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:pm, PMID:12641450]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0036042", "name": "long-chain fatty acyl-CoA binding", "changes": { "definition": { "current": "\"Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.\" [GOC:krc, GOC:pm]", "previous": "\"Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.\" [GOC:krc, GOC:pm]" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0042393", "name": "histone binding", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0043399", "name": "tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity", "changes": { "name": { "current": "tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity", "previous": "tRNA A64-2'-O-ribosylphosphate transferase activity" }, "definition": { "current": "\"Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA.\" [GOC:jl, PMID:22030622, PMID:7954819]", "previous": "\"Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA.\" [GOC:jl, PMID:7954819]" }, "synonyms": { "current": [ "\"initiator tRNA phosphoribosyl-transferase activity\" EXACT []", "\"tRNA A64-2'-O-ribosylphosphate transferase activity\" EXACT []" ], "previous": [ "\"initiator tRNA phosphoribosyl-transferase activity\" EXACT []" ] } } }, { "id": "GO:0043759", "name": "2-methylbutanoate-CoA ligase activity", "changes": { "name": { "current": "2-methylbutanoate-CoA ligase activity", "previous": "methylbutanoate-CoA ligase activity" } } }, { "id": "GO:0044183", "name": "protein folding chaperone", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0045182", "name": "translation regulator activity", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_candida", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0045735", "name": "nutrient reservoir activity", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0047101", "name": "branched-chain alpha-keto acid dehydrogenase activity", "changes": { "name": { "current": "branched-chain alpha-keto acid dehydrogenase activity", "previous": "2-oxoisovalerate dehydrogenase (acylating) activity" }, "synonyms": { "current": [ "\"2-oxoisovalerate dehydrogenase (acylating) activity\" NARROW [EC:1.2.1.25]", "\"2-oxoisovalerate dehydrogenase activity\" RELATED [EC:1.2.1.25]", "\"3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)\" RELATED [EC:1.2.1.25]" ], "previous": [ "\"2-oxoisovalerate dehydrogenase activity\" RELATED [EC:1.2.1.25]", "\"3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)\" RELATED [EC:1.2.1.25]" ] } } }, { "id": "GO:0047450", "name": "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "changes": { "name": { "current": "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "previous": "(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity" }, "synonyms": { "current": [ "\"(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity\" EXACT []", "\"3-hydroxybutyryl acyl carrier protein dehydratase activity\" EXACT []", "\"beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity\" EXACT []", "\"crotonoyl-[acyl-carrier protein] hydratase activity\" EXACT []", "\"crotonoyl-[acyl-carrier-protein] hydratase activity\" EXACT []", "\"crotonoyl-ACP hydratase activity\" EXACT []", "\"crotonoyl-acyl-carrier-protein hydratase activity\" EXACT []", "\"crotonyl acyl carrier protein hydratase activity\" EXACT []" ], "previous": [ "\"(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity\" EXACT []", "\"3-hydroxybutyryl acyl carrier protein dehydratase activity\" EXACT []", "\"beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity\" EXACT []", "\"crotonoyl-[acyl-carrier protein] hydratase activity\" EXACT []", "\"crotonoyl-[acyl-carrier-protein] hydratase activity\" BROAD []", "\"crotonoyl-ACP hydratase activity\" EXACT []", "\"crotonoyl-acyl-carrier-protein hydratase activity\" EXACT []", "\"crotonyl acyl carrier protein hydratase activity\" EXACT []" ] } } }, { "id": "GO:0047474", "name": "long-chain fatty acid--protein ligase activity", "changes": { "name": { "current": "long-chain fatty acid--protein ligase activity", "previous": "long-chain fatty acid luciferin component ligase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" }, "synonyms": { "current": [ "\"acyl-protein synthetase activity\" RELATED [EC:6.2.1.19]", "\"long-chain fatty acid luciferin component ligase activity\" EXACT []", "\"long-chain-fatty-acid luciferin component ligase activity\" EXACT [GOC:mah]", "\"long-chain-fatty-acid-luciferin-component ligase activity\" EXACT []", "\"long-chain-fatty-acid:protein ligase (AMP-forming)\" RELATED [EC:6.2.1.19]" ], "previous": [ "\"acyl-protein synthetase activity\" RELATED [EC:6.2.1.19]", "\"long-chain-fatty-acid luciferin component ligase activity\" EXACT [GOC:mah]", "\"long-chain-fatty-acid-luciferin-component ligase activity\" EXACT []", "\"long-chain-fatty-acid:protein ligase (AMP-forming)\" RELATED [EC:6.2.1.19]" ] } } }, { "id": "GO:0047617", "name": "fatty acyl-CoA hydrolase activity", "changes": { "name": { "current": "fatty acyl-CoA hydrolase activity", "previous": "acyl-CoA hydrolase activity" }, "synonyms": { "current": [ "\"acyl coenzyme A hydrolase activity\" RELATED [EC:3.1.2.20]", "\"acyl coenzyme A thioesterase activity\" RELATED [EC:3.1.2.20]", "\"acyl-CoA hydrolase activity\" BROAD []", "\"acyl-CoA thioesterase activity\" EXACT []", "\"acyl-CoA thioesterase I activity\" NARROW []", "\"acyl-CoA thioesterase II activity\" NARROW []", "\"acyl-CoA thiolesterase activity\" EXACT []", "\"thioesterase B\" RELATED [EC:3.1.2.20]", "\"thioesterase II\" RELATED [EC:3.1.2.20]" ], "previous": [ "\"acyl coenzyme A hydrolase activity\" RELATED [EC:3.1.2.20]", "\"acyl coenzyme A thioesterase activity\" RELATED [EC:3.1.2.20]", "\"acyl-CoA thioesterase activity\" EXACT []", "\"acyl-CoA thioesterase I activity\" NARROW []", "\"acyl-CoA thioesterase II activity\" NARROW []", "\"acyl-CoA thiolesterase activity\" EXACT []", "\"thioesterase B\" RELATED [EC:3.1.2.20]", "\"thioesterase II\" RELATED [EC:3.1.2.20]" ] }, "subsets": { "current": [ "goslim_chembl" ], "previous": "N/A" } } }, { "id": "GO:0047720", "name": "indoleacetaldoxime dehydratase activity", "changes": { "synonyms": { "current": [ "\"(indol-3-yl)acetaldehyde-oxime hydro-lyase activity\" EXACT [EC:4.8.1.3]", "\"3-indoleacetaldoxime hydro-lyase activity\" EXACT [EC:4.8.1.3]", "\"indole-3-acetaldehyde-oxime hydro-lyase activity\" EXACT [EC:4.8.1.3]", "\"indole-3-acetaldoxime hydro-lyase activity\" EXACT [EC:4.8.1.3]", "\"indoleacetaldoxime hydro-lyase activity\" EXACT [EC:4.8.1.3]" ], "previous": [ "\"(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]\" RELATED [EC:4.99.1.6]", "\"(indol-3-yl)acetaldehyde-oxime hydro-lyase activity\" RELATED [EC:4.99.1.6]", "\"3-indoleacetaldoxime hydro-lyase activity\" RELATED [EC:4.99.1.6]", "\"indole-3-acetaldehyde-oxime hydro-lyase activity\" RELATED [EC:4.99.1.6]", "\"indole-3-acetaldoxime hydro-lyase activity\" RELATED [EC:4.99.1.6]", "\"indoleacetaldoxime hydro-lyase activity\" RELATED [EC:4.99.1.6]" ] } } }, { "id": "GO:0047904", "name": "fructose 5-dehydrogenase activity", "changes": { "synonyms": { "current": [ "\"D-fructose dehydrogenase activity\" RELATED [EC:1.1.5.14]" ], "previous": [ "\"D-fructose dehydrogenase activity\" RELATED [EC:1.1.99.11]", "\"D-fructose:(acceptor) 5-oxidoreductase activity\" RELATED [EC:1.1.99.11]", "\"D-fructose:acceptor 5-oxidoreductase activity\" RELATED [EC:1.1.99.11]", "\"fructose 5-dehydrogenase (acceptor)\" RELATED [EC:1.1.99.11]" ] } } }, { "id": "GO:0050135", "name": "NADP+ nucleosidase activity", "changes": { "name": { "current": "NADP+ nucleosidase activity", "previous": "NAD(P)+ nucleosidase activity" }, "synonyms": { "current": [ "\"NAD(P)+ nucleosidase activity\" BROAD []", "\"NADP nucleosidase activity\" EXACT []", "\"NADP(+) nucleosidase activity\" EXACT []", "\"NADP+ glycohydrolase activity\" RELATED []", "\"NADPase activity\" RELATED []" ], "previous": [ "\"NAD(P) nucleosidase activity\" EXACT []", "\"NAD(P)(+) nucleosidase activity\" EXACT []", "\"NAD(P)+ glycohydrolase activity\" RELATED [EC:3.2.2.6]", "\"NAD(P)ase activity\" RELATED [EC:3.2.2.6]", "\"nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity\" RELATED [EC:3.2.2.6]", "\"nicotinamide adenine dinucleotide (phosphate) nucleosidase activity\" RELATED [EC:3.2.2.6]", "\"triphosphopyridine nucleotidase activity\" RELATED [EC:3.2.2.6]" ] } } }, { "id": "GO:0050421", "name": "nitrite reductase (NO-forming) activity", "changes": { "comment": { "current": "N/A", "previous": "Note that EC:1.7.99.3 was merged into this term." } } }, { "id": "GO:0051908", "name": "double-stranded DNA 5'-3' DNA exonuclease activity", "changes": { "name": { "current": "double-stranded DNA 5'-3' DNA exonuclease activity", "previous": "double-stranded DNA 5'-3' exodeoxyribonuclease activity" }, "synonyms": { "current": [ "\"double-stranded DNA 5'-3' exodeoxyribonuclease activity\" EXACT []", "\"double-stranded DNA specific 5'-3' exodeoxyribonuclease activity\" RELATED []" ], "previous": [ "\"double-stranded DNA specific 5'-3' exodeoxyribonuclease activity\" RELATED []" ] } } }, { "id": "GO:0052642", "name": "lysophosphatidic acid phosphatase activity", "changes": { "synonyms": { "current": [ "\"1-acyl-sn-glycerol 3-phosphatase activity\" EXACT [EC:3.1.3.106]", "\"2-lysophosphatidate phosphatase activity\" EXACT [EC:3.1.3.106]", "\"LPA phosphatase activity\" EXACT []", "\"lysophosphatidate phosphatase activity\" EXACT []" ], "previous": [ "\"LPA phosphatase activity\" EXACT []", "\"lysophosphatidate phosphatase activity\" EXACT []" ] } } }, { "id": "GO:0052815", "name": "medium-chain fatty acyl-CoA hydrolase activity", "changes": { "name": { "current": "medium-chain fatty acyl-CoA hydrolase activity", "previous": "medium-chain acyl-CoA hydrolase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" }, "synonyms": { "current": [ "\"medium-chain acyl coenzyme A hydrolase activity\" RELATED []", "\"medium-chain acyl-thioester hydrolase activity\" RELATED []", "\"medium-chain hydrolase activity\" RELATED []", "\"medium-chain-acyl-CoA hydrolase activity\" RELATED []" ], "previous": [ "\"medium-chain acyl coenzyme A hydrolase activity\" RELATED [EC:3.1.2.19]", "\"medium-chain acyl-thioester hydrolase activity\" RELATED [EC:3.1.2.19]", "\"medium-chain hydrolase activity\" RELATED [EC:3.1.2.19]", "\"medium-chain-acyl-CoA hydrolase activity\" RELATED [EC:3.1.2.19]" ] } } }, { "id": "GO:0052816", "name": "long-chain fatty acyl-CoA hydrolase activity", "changes": { "name": { "current": "long-chain fatty acyl-CoA hydrolase activity", "previous": "long-chain acyl-CoA hydrolase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" }, "synonyms": { "current": [ "\"long-chain acyl coenzyme A hydrolase activity\" RELATED []", "\"long-chain acyl-thioester hydrolase activity\" RELATED []", "\"long-chain hydrolase activity\" RELATED []", "\"long-chain-acyl-CoA hydrolase activity\" RELATED []" ], "previous": [ "\"long-chain acyl coenzyme A hydrolase activity\" RELATED [EC:3.1.2.19]", "\"long-chain acyl-thioester hydrolase activity\" RELATED [EC:3.1.2.19]", "\"long-chain hydrolase activity\" RELATED [EC:3.1.2.19]", "\"long-chain-acyl-CoA hydrolase activity\" RELATED [EC:3.1.2.19]" ] } } }, { "id": "GO:0052817", "name": "very long-chain fatty acyl-CoA hydrolase activity", "changes": { "name": { "current": "very long-chain fatty acyl-CoA hydrolase activity", "previous": "very long chain acyl-CoA hydrolase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" }, "synonyms": { "current": [ "\"very long-chain acyl coenzyme A hydrolase activity\" RELATED []", "\"very long-chain acyl-thioester hydrolase activity\" RELATED []", "\"very long-chain hydrolase activity\" RELATED []", "\"very long-chain-acyl-CoA hydrolase activity\" RELATED []" ], "previous": [ "\"very long-chain acyl coenzyme A hydrolase activity\" RELATED [EC:3.1.2.19]", "\"very long-chain acyl-thioester hydrolase activity\" RELATED [EC:3.1.2.19]", "\"very long-chain hydrolase activity\" RELATED [EC:3.1.2.19]", "\"very long-chain-acyl-CoA hydrolase activity\" RELATED [EC:3.1.2.19]" ] } } }, { "id": "GO:0060089", "name": "molecular transducer activity", "changes": { "subsets": { "current": [ "gocheck_do_not_manually_annotate", "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_manually_annotate", "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0060090", "name": "molecular adaptor activity", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0061522", "name": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.\" [RHEA:26309]", "previous": "\"Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.\" [GOC:dph]" } } }, { "id": "GO:0061542", "name": "3-demethylubiquinol-n 3-O-methyltransferase activity", "changes": { "comment": { "current": "Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.", "previous": "N/A" } } }, { "id": "GO:0061809", "name": "NAD+ nucleotidase, cyclic ADP-ribose generating", "changes": { "synonyms": { "current": [ "\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase\" EXACT []", "\"NAD hydrolase\" NARROW []", "\"NAD(+) nucleosidase\" NARROW []", "\"NADase\" NARROW []", "\"nicotinamide adenine dinucleotide nucleosidase\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0070579", "name": "5-methylcytosine dioxygenase activity", "changes": { "name": { "current": "5-methylcytosine dioxygenase activity", "previous": "methylcytosine dioxygenase activity" }, "comment": { "current": "This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleodides in the DNA.", "previous": "N/A" }, "synonyms": { "current": [ "\"methylcytosine dioxygenase activity\" BROAD []" ], "previous": "N/A" } } }, { "id": "GO:0070991", "name": "medium-chain fatty acyl-CoA dehydrogenase activity", "changes": { "name": { "current": "medium-chain fatty acyl-CoA dehydrogenase activity", "previous": "medium-chain-acyl-CoA dehydrogenase activity" }, "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0080019", "name": "alcohol-forming very long-chain fatty acyl-CoA reductase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0080123", "name": "jasmonoyl-L-amino acid ligase activity", "changes": { "name": { "current": "jasmonoyl-L-amino acid ligase activity", "previous": "jasmonate-amino synthetase activity" }, "synonyms": { "current": [ "\"ja-amino synthetase activity\" EXACT []", "\"jasmonate-amido synthetase activity\" EXACT []", "\"jasmonate-amino acid conjugate synthetase activity\" EXACT []", "\"jasmonate-amino acid synthetase activity\" EXACT []", "\"jasmonate-amino synthetase activity\" EXACT []", "\"jasmonate:amino acid synthetase activity\" EXACT []", "\"jasmonic acid-amino synthetase activity\" EXACT []", "\"jasmonyl-amino synthetase activity\" EXACT []" ], "previous": [ "\"ja-amino synthetase activity\" EXACT []", "\"jasmonate-amido synthetase activity\" EXACT []", "\"jasmonate-amino acid conjugate synthetase activity\" EXACT []", "\"jasmonate-amino acid synthetase activity\" EXACT []", "\"jasmonate:amino acid synthetase activity\" EXACT []", "\"jasmonic acid-amino synthetase activity\" EXACT []", "\"jasmonyl-amino synthetase activity\" EXACT []" ] } } }, { "id": "GO:0090729", "name": "toxin activity", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0098631", "name": "cell adhesion mediator activity", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0098772", "name": "molecular function regulator activity", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_flybase_ribbon", "goslim_generic", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_annotate", "goslim_flybase_ribbon", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0102682", "name": "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity", "changes": { "name": { "current": "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity", "previous": "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity" }, "synonyms": { "current": [ "\"N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0102965", "name": "alcohol-forming long-chain fatty acyl-CoA reductase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0140096", "name": "catalytic activity, acting on a protein", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140097", "name": "catalytic activity, acting on DNA", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140098", "name": "catalytic activity, acting on RNA", "changes": { "subsets": { "current": [ "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140104", "name": "molecular carrier activity", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_generic", "goslim_prokaryote" ], "previous": [ "gocheck_do_not_annotate", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140299", "name": "small molecule sensor activity", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140313", "name": "molecular sequestering activity", "changes": { "subsets": { "current": [ "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0140657", "name": "ATP-dependent activity", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "gocheck_do_not_annotate", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0140692", "name": "very long-chain fatty acid omega-hydroxylase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } }, { "id": "GO:0140981", "name": "medium-chain fatty acid omega-hydroxylase activity", "changes": { "comment": { "current": "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).", "previous": "N/A" } } } ], "cellular_component": [ { "id": "GO:0005576", "name": "extracellular region", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005615", "name": "extracellular space", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "prokaryote_subset" ] } } }, { "id": "GO:0005618", "name": "cell wall", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_candida", "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "gocheck_do_not_annotate", "goslim_candida", "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005694", "name": "chromosome", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005737", "name": "cytoplasm", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005840", "name": "ribosome", "changes": { "subsets": { "current": [ "goslim_candida", "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_candida", "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005856", "name": "cytoskeleton", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pir", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0005886", "name": "plasma membrane", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_plant", "goslim_prokaryote", "goslim_yeast" ], "previous": [ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_plant", "goslim_yeast", "prokaryote_subset" ] } } }, { "id": "GO:0009279", "name": "cell outer membrane", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0009579", "name": "thylakoid", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "prokaryote_subset" ] } } }, { "id": "GO:0031012", "name": "extracellular matrix", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0031533", "name": "mRNA capping enzyme complex", "changes": { "name": { "current": "mRNA capping enzyme complex", "previous": "mRNA cap methyltransferase complex" }, "definition": { "current": "\"A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.\" [GOC:vw, PMID:10347220, PMID:12455993, PMID:9345280]", "previous": "\"A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.\" [GOC:vw, PMID:10347220]" }, "synonyms": { "current": "N/A", "previous": [ "\"mRNA (guanine-N7) methyltransferase complex\" EXACT []", "\"mRNA capping enzyme complex\" EXACT [GOC:vw]" ] } } }, { "id": "GO:0039615", "name": "T=1 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.\" [VZ:1057]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.\" [UniProtKB-KW:KW-1140, VZ:1057]" } } }, { "id": "GO:0039616", "name": "T=2 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers.\" [VZ:838]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers.\" [UniProtKB-KW:KW-1141, VZ:838]" } } }, { "id": "GO:0039617", "name": "T=3 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.\" [VZ:806]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.\" [UniProtKB-KW:KW-1142, VZ:806]" } } }, { "id": "GO:0039618", "name": "T=pseudo3 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.\" [VZ:809]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.\" [UniProtKB-KW:KW-1143, VZ:809]" } } }, { "id": "GO:0039619", "name": "T=4 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres.\" [VZ:808]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres.\" [UniProtKB-KW:KW-1144, VZ:808]" } } }, { "id": "GO:0039620", "name": "T=7 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres.\" [VZ:804]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres.\" [UniProtKB-KW:KW-1145, VZ:804]" } } }, { "id": "GO:0039621", "name": "T=13 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres.\" [VZ:260]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres.\" [UniProtKB-KW:KW-1146, VZ:260]" } } }, { "id": "GO:0039622", "name": "T=16 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres.\" [VZ:807]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres.\" [UniProtKB-KW:KW-1147, VZ:807]" } } }, { "id": "GO:0039623", "name": "T=25 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres.\" [VZ:810]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres.\" [UniProtKB-KW:KW-1148, VZ:810]" } } }, { "id": "GO:0039628", "name": "T=169 icosahedral viral capsid", "changes": { "definition": { "current": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins.\" [GOC:plm, VZ:10117]", "previous": "\"The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins.\" [GOC:plm, UniProtKB-KW:KW-1150]" } } }, { "id": "GO:0042597", "name": "periplasmic space", "changes": { "subsets": { "current": [ "goslim_metagenomics", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_metagenomics", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0042995", "name": "cell projection", "changes": { "subsets": { "current": [ "goslim_agr", "goslim_flybase_ribbon", "goslim_mouse", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_agr", "goslim_flybase_ribbon", "goslim_mouse", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0043226", "name": "organelle", "changes": { "subsets": { "current": [ "goslim_chembl", "goslim_generic", "goslim_pir", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_pir", "prokaryote_subset" ] } } }, { "id": "GO:0043590", "name": "bacterial nucleoid", "changes": { "subsets": { "current": [ "goslim_prokaryote" ], "previous": [ "prokaryote_subset" ] } } }, { "id": "GO:0098015", "name": "virus tail", "changes": { "definition": { "current": "\"Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell.\" [GOC:bm, VZ:3958]", "previous": "\"Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell.\" [GOC:bm]" } } }, { "id": "GO:0098021", "name": "viral capsid, decoration", "changes": { "definition": { "current": "\"Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential.\" [GOC:bm, VZ:4398]", "previous": "\"Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential.\" [GOC:bm]" } } }, { "id": "GO:0098024", "name": "virus tail, fiber", "changes": { "definition": { "current": "\"The fibrous region of the virus tail used to scan, recognize and attach to the host cell.\" [GOC:bm, VZ:4416]", "previous": "\"The fibrous region of the virus tail used to scan, recognize and attach to the host cell.\" [GOC:bm]" } } }, { "id": "GO:0098025", "name": "virus tail, baseplate", "changes": { "definition": { "current": "\"Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached.\" [GOC:bm, VZ:3957]", "previous": "\"Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached.\" [GOC:bm]" } } }, { "id": "GO:0098026", "name": "virus tail, tube", "changes": { "definition": { "current": "\"The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [GOC:bm, VZ:3960]", "previous": "\"The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.\" [GOC:bm]" } } }, { "id": "GO:0098027", "name": "virus tail, sheath", "changes": { "definition": { "current": "\"The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm.\" [GOC:bm, VZ:3959]", "previous": "\"The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm.\" [GOC:bm]" } } }, { "id": "GO:0120330", "name": "rixosome complex", "changes": { "synonyms": { "current": [ "\"rix1 complex\" NARROW []" ], "previous": "N/A" } } } ] }, "cross_references": { "molecular_function": [ { "id": "GO:0000104", "name": "succinate dehydrogenase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R00412", "RHEA:16357" ], "previous": [ "KEGG:R00412", "RHEA:16357" ] } } }, { "id": "GO:0000170", "name": "sphingosine hydroxylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-428260 \"DEGS2 oxygenates dihydroceramide\"" ], "previous": [ "Reactome:R-HSA-428260 \"dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O\"" ] } } }, { "id": "GO:0000175", "name": "3'-5'-RNA exonuclease activity", "changes": { "xrefs": { "current": [ "EC:3.1.13.-", "Reactome:R-HSA-430028 \"Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion\"", "Reactome:R-HSA-6791222 \"21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA\"", "Reactome:R-HSA-6791227 \"47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA\"", "Reactome:R-HSA-9682603 \"nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA\"", "Reactome:R-HSA-9694632 \"nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA\"", "Reactome:R-HSA-9822437 \"DIS3L2 hydrolyzes uridylated mRNA\"", "Reactome:R-HSA-9836585 \"SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides\"", "Reactome:R-HSA-9836822 \"REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides\"" ], "previous": [ "EC:3.1.13.-", "Reactome:R-HSA-430028 \"Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion\"", "Reactome:R-HSA-6791222 \"21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA\"", "Reactome:R-HSA-6791227 \"47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA\"", "Reactome:R-HSA-9682603 \"nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA\"", "Reactome:R-HSA-9694632 \"nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA\"" ] } } }, { "id": "GO:0000386", "name": "second spliceosomal transesterification activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9770236 \"Formation of the Spliceosomal P complex and exon ligation\"" ], "previous": [ "Reactome:R-HSA-9770236 \"Formation of the Spliceosomal P complex and exon ligation (new)\"" ] } } }, { "id": "GO:0001665", "name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.3", "MetaCyc:2.4.99.3-RXN", "Reactome:R-HSA-4084980 \"ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)\"", "Reactome:R-HSA-9603991 \"ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG\"", "Reactome:R-HSA-9846305 \"ST6GALNAC5,6 transfer Neu5Ac to GM1b\"", "RHEA:11136" ], "previous": [ "EC:2.4.3.3", "MetaCyc:2.4.99.3-RXN", "Reactome:R-HSA-4084980 \"ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)\"", "Reactome:R-HSA-9603991 \"ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG\"", "RHEA:11136" ] } } }, { "id": "GO:0001727", "name": "lipid kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-428273 \"SPHK1 phosphorylates sphingoid\"", "Reactome:R-HSA-9695949 \"SPHK2 phosphorylates sphingoid\"" ], "previous": "N/A" } } }, { "id": "GO:0001733", "name": "galactosylceramide sulfotransferase activity", "changes": { "xrefs": { "current": [ "EC:2.8.2.11", "MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN", "Reactome:R-HSA-9844587 \"GAL3ST1 transfers sulfate to GalCer,LacCer\"", "RHEA:20613" ], "previous": [ "EC:2.8.2.11", "MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN", "RHEA:20613" ] } } }, { "id": "GO:0002151", "name": "G-quadruplex RNA binding", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9836998 \"GRSF1 unwinds quadruplex G regions in RNA\"" ], "previous": "N/A" } } }, { "id": "GO:0002950", "name": "ceramide phosphoethanolamine synthase activity", "changes": { "xrefs": { "current": [ "EC:2.7.8.n3", "Reactome:R-HSA-8959462 \"SAMD8 transfers phosphatidyl from PE onto C16DH CER\"" ], "previous": [ "EC:2.7.8.n3", "Reactome:R-HSA-8959462 \"SAMD8 transforms PE and CERA to CPE\"" ] } } }, { "id": "GO:0003724", "name": "RNA helicase activity", "changes": { "xrefs": { "current": [ "EC:3.6.4.13", "MetaCyc:RXN-11109", "Reactome:R-HSA-72647 \"Cap-bound mRNA is activated by helicases\"", "Reactome:R-HSA-9770129 \"Formation of the Spliceosomal A complex\"", "Reactome:R-HSA-9770131 \"Formation of the Spliceosomal B* complex\"", "Reactome:R-HSA-9770141 \"Formation of the Spliceosomal C* complex\"", "Reactome:R-HSA-9770142 \"Formation of the Spliceosomal B complex\"", "Reactome:R-HSA-9770145 \"Formation of the Spliceosomal Bact complex\"" ], "previous": [ "EC:3.6.4.13", "MetaCyc:RXN-11109", "Reactome:R-HSA-72647 \"Cap-bound mRNA is activated by helicases\"", "Reactome:R-HSA-9770129 \"Formation of the Spliceosomal A complex (update)\"", "Reactome:R-HSA-9770131 \"Formation of the Spliceosomal B* complex (new)\"", "Reactome:R-HSA-9770141 \"Formation of the Spliceosomal C* complex (update)\"", "Reactome:R-HSA-9770142 \"Formation of the Spliceosomal B complex (new)\"", "Reactome:R-HSA-9770145 \"Formation of the Spliceosomal Bact complex (new)\"" ] } } }, { "id": "GO:0003828", "name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.8", "MetaCyc:2.4.99.8-RXN", "Reactome:R-HSA-1022133 \"ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-4084978 \"ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues\"", "Reactome:R-HSA-422454 \"Polysialylation of NCAM1\"", "Reactome:R-HSA-9845587 \"ST8SIA5 transfers Neu5Ac to gangliosides\"", "RHEA:19313" ], "previous": [ "EC:2.4.3.8", "MetaCyc:2.4.99.8-RXN", "Reactome:R-HSA-1022133 \"ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-4084978 \"ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues\"", "Reactome:R-HSA-422454 \"Polysialylation of NCAM1\"", "RHEA:19313" ] } } }, { "id": "GO:0003836", "name": "beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.4", "MetaCyc:2.4.99.4-RXN", "Reactome:R-HSA-1022129 \"ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-1912378 \"Sialylation of Pre-NOTCH\"", "Reactome:R-HSA-2046285 \"The keratan chain can be capped by N-acetylneuraminic acid\"", "Reactome:R-HSA-3656258 \"Defective ST3GAL3 does not transfer SA to keratan\"", "Reactome:R-HSA-4084984 \"ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)\"", "Reactome:R-HSA-9603987 \"ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG\"", "Reactome:R-HSA-9605600 \"ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG\"", "Reactome:R-HSA-981497 \"ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position\"", "Reactome:R-HSA-9844860 \"ST3GAL5 transfers NeuNAc to ceramides\"", "Reactome:R-HSA-9845538 \"ST3GAL2,3 transfer Neu5Ac to gangliosides\"", "RHEA:21616" ], "previous": [ "EC:2.4.3.4", "MetaCyc:2.4.99.4-RXN", "Reactome:R-HSA-1022129 \"ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-1912378 \"Sialylation of Pre-NOTCH\"", "Reactome:R-HSA-2046285 \"The keratan chain can be capped by N-acetylneuraminic acid\"", "Reactome:R-HSA-3656258 \"Defective ST3GAL3 does not transfer SA to keratan\"", "Reactome:R-HSA-4084984 \"ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)\"", "Reactome:R-HSA-9603987 \"ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG\"", "Reactome:R-HSA-9605600 \"ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG\"", "Reactome:R-HSA-981497 \"ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position\"", "RHEA:21616" ] } } }, { "id": "GO:0003947", "name": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.92", "MetaCyc:2.4.1.92-RXN", "Reactome:R-HSA-8856223 \"B4GALNT1 dimer transfers GalNAc to gangliosides\"", "RHEA:12588" ], "previous": [ "EC:2.4.1.92", "MetaCyc:2.4.1.92-RXN", "Reactome:R-HSA-8856223 \"B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides\"", "RHEA:12588" ] } } }, { "id": "GO:0003953", "name": "NAD+ nucleosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.2.5", "MetaCyc:RXN-13859", "Reactome:R-HSA-8870346 \"BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose\"", "Reactome:R-HSA-8938076 \"CD38 hydrolyses NAD+ to NAM and ADP-ribose\"", "RHEA:16301" ], "previous": [ "Reactome:R-HSA-8870346 \"BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose\"", "Reactome:R-HSA-8938076 \"CD38 hydrolyses NAD+ to NAM and ADP-ribose\"", "RHEA:16301" ] } } }, { "id": "GO:0003968", "name": "RNA-dependent RNA polymerase activity", "changes": { "xrefs": { "current": [ "EC:2.7.7.48", "MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN", "Reactome:R-HSA-168280 \"Priming and Initiation of Transcription\"", "Reactome:R-HSA-168301 \"Elongation, Polyadenylation and Termination\"", "Reactome:R-HSA-192624 \"cRNA Extension\"", "Reactome:R-HSA-192832 \"Initiation of cRNA Synthesis\"", "Reactome:R-HSA-192851 \"vRNA Extension\"", "Reactome:R-HSA-192916 \"Initiation of vRNA Synthesis\"", "Reactome:R-HSA-9681651 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9681674 \"nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement\"", "Reactome:R-HSA-9681840 \"RTC synthesizes SARS-CoV-1 plus strand genomic RNA\"", "Reactome:R-HSA-9682465 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9682563 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9685639 \"Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9685681 \"Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694277 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9694344 \"Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9694506 \"Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694549 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9694581 \"RTC synthesizes SARS-CoV-2 plus strand genomic RNA\"", "Reactome:R-HSA-9694605 \"nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement\"", "Reactome:R-HSA-9694792 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9828639 \"Transcription of respiratory syncytial virus subgenomic positive sense mRNAs\"", "Reactome:R-HSA-9834719 \"Synthesis of negative sense genomic RNA of respiratory syncytial virus\"", "Reactome:R-HSA-9834736 \"Synthesis of antigenomic RNA of human respiratory syncytial virus\"", "Reactome:R-HSA-9837511 \"Abortive replication of hRSV A\"" ], "previous": [ "EC:2.7.7.48", "MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN", "Reactome:R-HSA-168280 \"Priming and Initiation of Transcription\"", "Reactome:R-HSA-168301 \"Elongation, Polyadenylation and Termination\"", "Reactome:R-HSA-192624 \"cRNA Extension\"", "Reactome:R-HSA-192832 \"Initiation of cRNA Synthesis\"", "Reactome:R-HSA-192851 \"vRNA Extension\"", "Reactome:R-HSA-192916 \"Initiation of vRNA Synthesis\"", "Reactome:R-HSA-9681651 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9681674 \"nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement\"", "Reactome:R-HSA-9681840 \"RTC synthesizes SARS-CoV-1 plus strand genomic RNA\"", "Reactome:R-HSA-9682465 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9682563 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9685639 \"Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9685681 \"Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694277 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9694344 \"Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9694506 \"Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694549 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9694581 \"RTC synthesizes SARS-CoV-2 plus strand genomic RNA\"", "Reactome:R-HSA-9694605 \"nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement\"", "Reactome:R-HSA-9694792 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"" ] } } }, { "id": "GO:0003995", "name": "acyl-CoA dehydrogenase activity", "changes": { "xrefs": { "current": [ "MetaCyc:ACYLCOADEHYDROG-RXN", "MetaCyc:RXN-13624", "Reactome:R-HSA-109341 \"dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA\"", "Reactome:R-HSA-5695980 \"ACAD10 dehydrogenates S-2MPDA-CoA\"", "Reactome:R-HSA-5695989 \"ACAD11 dehydrogenates BH-CoA\"", "Reactome:R-HSA-70800 \"alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2\"", "Reactome:R-HSA-70859 \"isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2\"", "Reactome:R-HSA-77263 \"lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2\"", "Reactome:R-HSA-77274 \"myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77299 \"palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77319 \"Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2\"", "Reactome:R-HSA-77327 \"Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77338 \"Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77345 \"Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2\"", "RHEA:44704" ], "previous": [ "MetaCyc:ACYLCOADEHYDROG-RXN", "Reactome:R-HSA-109341 \"dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA\"", "Reactome:R-HSA-5695980 \"ACAD10 dehydrogenates S-2MPDA-CoA\"", "Reactome:R-HSA-5695989 \"ACAD11 dehydrogenates BH-CoA\"", "Reactome:R-HSA-70800 \"alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2\"", "Reactome:R-HSA-70859 \"isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2\"", "Reactome:R-HSA-77263 \"lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2\"", "Reactome:R-HSA-77274 \"myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77299 \"palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77319 \"Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2\"", "Reactome:R-HSA-77327 \"Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77338 \"Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77345 \"Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2\"", "RHEA:44704" ] } } }, { "id": "GO:0004085", "name": "butyryl-CoA dehydrogenase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R01178", "MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN", "RHEA:24004", "UM-BBD_reactionID:r0013" ], "previous": [ "EC:1.3.8.1", "KEGG_REACTION:R01178", "MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN", "RHEA:24004", "UM-BBD_reactionID:r0013" ] } } }, { "id": "GO:0004098", "name": "cerebroside-sulfatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.6.8", "MetaCyc:CEREBROSIDE-SULFATASE-RXN", "Reactome:R-HSA-1606807 \"ARSA removes sulfate from PSAP(195-273):Sulfatide\"", "Reactome:R-HSA-9840949 \"ARSA removes sulfate from SM3\"", "RHEA:21300" ], "previous": [ "EC:3.1.6.8", "MetaCyc:CEREBROSIDE-SULFATASE-RXN", "Reactome:R-HSA-1606807 \"Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside\"", "RHEA:21300" ] } } }, { "id": "GO:0004126", "name": "cytidine deaminase activity", "changes": { "xrefs": { "current": [ "EC:3.5.4.5", "MetaCyc:CYTIDEAM2-RXN", "Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"", "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"", "Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine\"", "RHEA:16069" ], "previous": [ "EC:3.5.4.5", "MetaCyc:CYTIDEAM2-RXN", "Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"", "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"", "RHEA:16069" ] } } }, { "id": "GO:0004140", "name": "dephospho-CoA kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.24", "KEGG_REACTION:R00130", "MetaCyc:DEPHOSPHOCOAKIN-RXN", "Reactome:R-HSA-196773 \"COASY phosphorylates DP-CoA\"", "Reactome:R-HSA-9837337 \"DCAKD phosphorylates DP-CoA\"", "RHEA:18245" ], "previous": [ "EC:2.7.1.24", "KEGG_REACTION:R00130", "MetaCyc:DEPHOSPHOCOAKIN-RXN", "Reactome:R-HSA-196773 \"COASY phosphorylates DP-CoA\"", "RHEA:18245" ] } } }, { "id": "GO:0004164", "name": "diphthine synthase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.98", "MetaCyc:RXN-14326", "Reactome:R-HSA-5358484 \"DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2\"", "RHEA:36415" ], "previous": [ "EC:2.1.1.98", "MetaCyc:RXN-11370", "Reactome:R-HSA-5358484 \"DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2\"", "RHEA:36415" ] } } }, { "id": "GO:0004176", "name": "ATP-dependent peptidase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9698929 \"pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex\"", "Reactome:R-HSA-9838004 \"LONP1 degrades mitochondrial inner membrane proteins\"", "Reactome:R-HSA-9838081 \"LONP1 degrades mitochondrial matrix proteins\"", "Reactome:R-HSA-9838289 \"CLPXP degrades mitochondrial matrix proteins\"", "Reactome:R-HSA-9839059 \"AFG3L2:SPG7 degrades SMDT1 (EMRE)\"", "Reactome:R-HSA-9839105 \"AFG3L2 degrades mitochondrial matrix proteins\"", "Reactome:R-HSA-9839113 \"AFG3L2 degrades mitochondrial inner membrane proteins\"", "Reactome:R-HSA-9839146 \"YME1L1 degrades mitochondrial inner membrane proteins\"", "Reactome:R-HSA-9839751 \"YME1L1 degrades mitochondrial intermembrane space proteins\"" ], "previous": [ "Reactome:R-HSA-9698929 \"pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex\"" ] } } }, { "id": "GO:0004222", "name": "metalloendopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.24.-", "Reactome:R-HSA-1168777 \"Metalloprotease cleavage of GHR\"", "Reactome:R-HSA-1251992 \"Cleavage of P-ERBB4jmA isoforms by ADAM17\"", "Reactome:R-HSA-1299476 \"MPP cleaves targeting peptide (presequence) of inner membrane precursors\"", "Reactome:R-HSA-1299478 \"MPP cleaves targeting peptide (presequence) of matrix precursors\"", "Reactome:R-HSA-1454757 \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\"", "Reactome:R-HSA-1454822 \"Collagen type I degradation by MMP1,2,8,13, PRSS2\"", "Reactome:R-HSA-1458433 \"Collagen type I degradation by MMP14\"", "Reactome:R-HSA-1474196 \"Collagen type II degradation by MMP14\"", "Reactome:R-HSA-1474210 \"Collagen type III degradation by MMP14\"", "Reactome:R-HSA-1474213 \"Collagen type III degradation by MMP1,8,9,13\"", "Reactome:R-HSA-1564112 \"Collagen type VI degradation by MMP2,9,11\"", "Reactome:R-HSA-1564117 \"Collagen type XIV degradation by MMP9,13\"", "Reactome:R-HSA-1564120 \"Collagen type VII degradation by MMP1,2,3\"", "Reactome:R-HSA-1564142 \"Collagen type IV degradation by MMP2,3,4,9,10,12\"", "Reactome:R-HSA-1564143 \"Collagen type X degradation by MMP1,2\"", "Reactome:R-HSA-1564164 \"Collagen type V degradation by MMP2,9,10\"", "Reactome:R-HSA-1564169 \"Collagen type VIII degradation by MMP1\"", "Reactome:R-HSA-1564179 \"Collagen type XI degradation by MMP1,2,3,9\"", "Reactome:R-HSA-1564184 \"Collagen type IX degradation by MMP3,13\"", "Reactome:R-HSA-1592310 \"Aggrecan degradation by ADAMTSs\"", "Reactome:R-HSA-1655851 \"S2P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-177946 \"Pro-EGF is cleaved to form mature EGF\"", "Reactome:R-HSA-181567 \"botC LC cleaves target cell STX1\"", "Reactome:R-HSA-194793 \"botC LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194796 \"botB LC cleaves target cell VAMP2\"", "Reactome:R-HSA-194800 \"botE LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194808 \"botF LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194809 \"botD LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194818 \"botA LC cleaves target cell SNAP25\"", "Reactome:R-HSA-2002428 \"Removal of fibrillar collagen N-propeptides\"", "Reactome:R-HSA-2002440 \"Removal of fibrillar collagen C-propeptides\"", "Reactome:R-HSA-2022141 \"Prolysyl oxidase activation\"", "Reactome:R-HSA-2168046 \"Collagen type XII degradation by MMP12\"", "Reactome:R-HSA-2168982 \"Collagen type XVI degradation by MMP9\"", "Reactome:R-HSA-2179402 \"Active MMP3 can cleave pro-HBEGF to form active HBEGF\"", "Reactome:R-HSA-2473584 \"Collagen type III degradation by MMP15\"", "Reactome:R-HSA-2473594 \"Collagen type II degradation by MMP15\"", "Reactome:R-HSA-2473596 \"Collagen type I degradation by MMP15\"", "Reactome:R-HSA-2484882 \"Collagen type X degradation by MMP3, 13\"", "Reactome:R-HSA-2485111 \"Collagen type III degradation by MMP10\"", "Reactome:R-HSA-2485148 \"Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13\"", "Reactome:R-HSA-2514790 \"Elastin degradation by MMP14\"", "Reactome:R-HSA-2514831 \"Fibrillin-1 degradation by MMP14\"", "Reactome:R-HSA-2533874 \"Laminin-511 degradation by MMP14\"", "Reactome:R-HSA-2533944 \"Fibronectin degradation by MMP10\"", "Reactome:R-HSA-2533950 \"Fibronectin degradation by MMP14, TMPRSS6\"", "Reactome:R-HSA-2533965 \"NID1 degradation by MMP14, MMP15\"", "Reactome:R-HSA-2533970 \"NID1 degradation by MMP3, 7\"", "Reactome:R-HSA-2534240 \"HSPG2 (perlecan) degradation by MMP14, MMP15\"", "Reactome:R-HSA-2534248 \"DCN (decorin) degradation by MMP2, MMP3, MMP7\"", "Reactome:R-HSA-2537499 \"Gelatin degradation by MMP19\"", "Reactome:R-HSA-264758 \"BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1\"", "Reactome:R-HSA-3371385 \"TNF- is cleaved by ADAM17 (TACE)\"", "Reactome:R-HSA-3788075 \"Brevican degradation by ADAMTS4, ADAMTS5\"", "Reactome:R-HSA-3791149 \"Brevican degradation by MMP1, 2, 3, 7,8,10,13,19\"", "Reactome:R-HSA-3791155 \"Laminin-322 degradation by MMP14\"", "Reactome:R-HSA-3791295 \"Aggrecan degradation by MMP1,2,3,7,9,12,13\"", "Reactome:R-HSA-3791319 \"NID1 degradation by MMP19\"", "Reactome:R-HSA-381435 \"Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381518 \"PAAP-A proteolyzes IGF:IGFBP4\"", "Reactome:R-HSA-381537 \"PAPP-A2 proteolyzes IGF:IGFBP5:ALS\"", "Reactome:R-HSA-3827958 \"E-cadherin degradation by MMP9, KLK7\"", "Reactome:R-HSA-3828025 \"DCN (decorin) degradation by MMP14\"", "Reactome:R-HSA-4086205 \"OPN (osteopontin) degradation by MMP3, MMP7\"", "Reactome:R-HSA-420818 \"MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-4224014 \"E-cadherin degradation by ADAM10, ADAM15\"", "Reactome:R-HSA-5228578 \"tetX LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250606 \"botD LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250892 \"botF LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250962 \"botG LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250978 \"botG LC cleaves target cell VAMP1\"", "Reactome:R-HSA-5333671 \"CLCAs self cleave\"", "Reactome:R-HSA-5362793 \"Hh-Np is cleaved by ADAM17 to promote ligand shedding\"", "Reactome:R-HSA-5694082 \"XK:KEL:Zn2+ cleaves EDN3\"", "Reactome:R-HSA-6784620 \"MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)\"", "Reactome:R-HSA-8867344 \"OMA1 hydrolyses OPA1\"", "Reactome:R-HSA-8874122 \"MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874187 \"MBTPS2 (S2P) cleaves CREB3L2\"", "Reactome:R-HSA-8874192 \"MBTPS2 (S2P) cleaves CREB3\"", "Reactome:R-HSA-8874194 \"MBTPS2 (S2P) cleaves CREB3L1\"", "Reactome:R-HSA-8874195 \"MBTPS2 (S2P) cleaves CREB3L4\"", "Reactome:R-HSA-8874201 \"MBTPS2 (S2P) cleaves CREB3L3\"", "Reactome:R-HSA-8876868 \"ECE1 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8877620 \"ECE2 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8940554 \"MMP2 cleaves OPTC\"", "Reactome:R-HSA-8940561 \"MMP7 cleaves OPTC\"", "Reactome:R-HSA-8940641 \"THOP1 cleaves oligopeptide fragment (8-16aa)\"", "Reactome:R-HSA-8940959 \"Neurolysin degrades neurotensin\"", "Reactome:R-HSA-8942302 \"MMP13 cleaves OPTC\"", "Reactome:R-HSA-8943959 \"MMP2, MMP9 cleave SCUBE3\"", "Reactome:R-HSA-8949649 \"PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)\"", "Reactome:R-HSA-8949659 \"AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU\"", "Reactome:R-HSA-8949668 \"YME1L1 proteolyzes unassembled proSMDT1\"", "Reactome:R-HSA-9624272 \"MMPs cleave HB-EGF\"", "Reactome:R-HSA-9822532 \"ADAMTS13 cleaves VWF multimer\"", "Reactome:R-HSA-9824402 \"ADAMTS13 variant does not cleave VWF multimer\"", "Reactome:R-HSA-9840408 \"OMA1 cleaves DELE1\"", "Reactome:R-HSA-9840532 \"OMA1 self-cleaves\"", "Reactome:R-HSA-9840564 \"OMA1 hydrolyzes YME1L1\"", "Reactome:R-HSA-9844241 \"ADAMTS13 cleaves VWF variant multimer\"" ], "previous": [ "EC:3.4.24.-", "Reactome:R-HSA-1168777 \"Metalloprotease cleavage of GHR\"", "Reactome:R-HSA-1251992 \"Cleavage of P-ERBB4jmA isoforms by ADAM17\"", "Reactome:R-HSA-1299476 \"MPP cleaves targeting peptide (presequence) of inner membrane precursors\"", "Reactome:R-HSA-1299478 \"MPP cleaves targeting peptide (presequence) of matrix precursors\"", "Reactome:R-HSA-1454757 \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\"", "Reactome:R-HSA-1454822 \"Collagen type I degradation by MMP1,2,8,13, PRSS2\"", "Reactome:R-HSA-1458433 \"Collagen type I degradation by MMP14\"", "Reactome:R-HSA-1474196 \"Collagen type II degradation by MMP14\"", "Reactome:R-HSA-1474210 \"Collagen type III degradation by MMP14\"", "Reactome:R-HSA-1474213 \"Collagen type III degradation by MMP1,8,9,13\"", "Reactome:R-HSA-1564112 \"Collagen type VI degradation by MMP2,9,11\"", "Reactome:R-HSA-1564117 \"Collagen type XIV degradation by MMP9,13\"", "Reactome:R-HSA-1564120 \"Collagen type VII degradation by MMP1,2,3\"", "Reactome:R-HSA-1564142 \"Collagen type IV degradation by MMP2,3,4,9,10,12\"", "Reactome:R-HSA-1564143 \"Collagen type X degradation by MMP1,2\"", "Reactome:R-HSA-1564164 \"Collagen type V degradation by MMP2,9,10\"", "Reactome:R-HSA-1564169 \"Collagen type VIII degradation by MMP1\"", "Reactome:R-HSA-1564179 \"Collagen type XI degradation by MMP1,2,3,9\"", "Reactome:R-HSA-1564184 \"Collagen type IX degradation by MMP3,13\"", "Reactome:R-HSA-1592310 \"Aggrecan degradation by ADAMTSs\"", "Reactome:R-HSA-1655851 \"S2P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-177946 \"Pro-EGF is cleaved to form mature EGF\"", "Reactome:R-HSA-181567 \"botC LC cleaves target cell STX1\"", "Reactome:R-HSA-194793 \"botC LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194796 \"botB LC cleaves target cell VAMP2\"", "Reactome:R-HSA-194800 \"botE LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194808 \"botF LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194809 \"botD LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194818 \"botA LC cleaves target cell SNAP25\"", "Reactome:R-HSA-2002428 \"Removal of fibrillar collagen N-propeptides\"", "Reactome:R-HSA-2002440 \"Removal of fibrillar collagen C-propeptides\"", "Reactome:R-HSA-2022141 \"Prolysyl oxidase activation\"", "Reactome:R-HSA-2168046 \"Collagen type XII degradation by MMP12\"", "Reactome:R-HSA-2168982 \"Collagen type XVI degradation by MMP9\"", "Reactome:R-HSA-2179402 \"Active MMP3 can cleave pro-HBEGF to form active HBEGF\"", "Reactome:R-HSA-2473584 \"Collagen type III degradation by MMP15\"", "Reactome:R-HSA-2473594 \"Collagen type II degradation by MMP15\"", "Reactome:R-HSA-2473596 \"Collagen type I degradation by MMP15\"", "Reactome:R-HSA-2484882 \"Collagen type X degradation by MMP3, 13\"", "Reactome:R-HSA-2485111 \"Collagen type III degradation by MMP10\"", "Reactome:R-HSA-2485148 \"Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13\"", "Reactome:R-HSA-2514790 \"Elastin degradation by MMP14\"", "Reactome:R-HSA-2514831 \"Fibrillin-1 degradation by MMP14\"", "Reactome:R-HSA-2533874 \"Laminin-511 degradation by MMP14\"", "Reactome:R-HSA-2533944 \"Fibronectin degradation by MMP10\"", "Reactome:R-HSA-2533950 \"Fibronectin degradation by MMP14, TMPRSS6\"", "Reactome:R-HSA-2533965 \"NID1 degradation by MMP14, MMP15\"", "Reactome:R-HSA-2533970 \"NID1 degradation by MMP3, 7\"", "Reactome:R-HSA-2534240 \"HSPG2 (perlecan) degradation by MMP14, MMP15\"", "Reactome:R-HSA-2534248 \"DCN (decorin) degradation by MMP2, MMP3, MMP7\"", "Reactome:R-HSA-2537499 \"Gelatin degradation by MMP19\"", "Reactome:R-HSA-264758 \"BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1\"", "Reactome:R-HSA-3371385 \"TNF- is cleaved by ADAM17 (TACE)\"", "Reactome:R-HSA-3788075 \"Brevican degradation by ADAMTS4, ADAMTS5\"", "Reactome:R-HSA-3791149 \"Brevican degradation by MMP1, 2, 3, 7,8,10,13,19\"", "Reactome:R-HSA-3791155 \"Laminin-322 degradation by MMP14\"", "Reactome:R-HSA-3791295 \"Aggrecan degradation by MMP1,2,3,7,9,12,13\"", "Reactome:R-HSA-3791319 \"NID1 degradation by MMP19\"", "Reactome:R-HSA-381435 \"Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381518 \"PAAP-A proteolyzes IGF:IGFBP4\"", "Reactome:R-HSA-381537 \"PAPP-A2 proteolyzes IGF:IGFBP5:ALS\"", "Reactome:R-HSA-3827958 \"E-cadherin degradation by MMP9, KLK7\"", "Reactome:R-HSA-3828025 \"DCN (decorin) degradation by MMP14\"", "Reactome:R-HSA-4086205 \"OPN (osteopontin) degradation by MMP3, MMP7\"", "Reactome:R-HSA-420818 \"MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-4224014 \"E-cadherin degradation by ADAM10, ADAM15\"", "Reactome:R-HSA-5228578 \"tetX LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250606 \"botD LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250892 \"botF LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250962 \"botG LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250978 \"botG LC cleaves target cell VAMP1\"", "Reactome:R-HSA-5333671 \"CLCAs self cleave\"", "Reactome:R-HSA-5362793 \"Hh-Np is cleaved by ADAM17 to promote ligand shedding\"", "Reactome:R-HSA-5694082 \"XK:KEL:Zn2+ cleaves EDN3\"", "Reactome:R-HSA-6784620 \"MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)\"", "Reactome:R-HSA-8867344 \"OMA1 hydrolyses OPA1\"", "Reactome:R-HSA-8874187 \"MBTPS2 (S2P) cleaves CREB3L2\"", "Reactome:R-HSA-8874192 \"MBTPS2 (S2P) cleaves CREB3\"", "Reactome:R-HSA-8874194 \"MBTPS2 (S2P) cleaves CREB3L1\"", "Reactome:R-HSA-8874195 \"MBTPS2 (S2P) cleaves CREB3L4\"", "Reactome:R-HSA-8874201 \"MBTPS2 (S2P) cleaves CREB3L3\"", "Reactome:R-HSA-8876868 \"ECE1 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8877620 \"ECE2 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8940554 \"MMP2 cleaves OPTC\"", "Reactome:R-HSA-8940561 \"MMP7 cleaves OPTC\"", "Reactome:R-HSA-8940641 \"THOP1 cleaves oligopeptide fragment (8-16aa)\"", "Reactome:R-HSA-8940959 \"Neurolysin degrades neurotensin\"", "Reactome:R-HSA-8942302 \"MMP13 cleaves OPTC\"", "Reactome:R-HSA-8943959 \"MMP2, MMP9 cleave SCUBE3\"", "Reactome:R-HSA-8949649 \"PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)\"", "Reactome:R-HSA-8949659 \"AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU\"", "Reactome:R-HSA-8949668 \"YME1L1 proteolyzes unassembled proSMDT1\"", "Reactome:R-HSA-9624272 \"MMPs cleave HB-EGF\"" ] } } }, { "id": "GO:0004252", "name": "serine-type endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.21.-", "Reactome:R-HSA-114697 \"Activated thrombin (factor IIa) cleaves PAR3,4, activating them\"", "Reactome:R-HSA-1181152 \"Cleavage of NODAL proprotein\"", "Reactome:R-HSA-139893 \"Granzyme-B activates BID by cleavage\"", "Reactome:R-HSA-140599 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides\"", "Reactome:R-HSA-140664 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)\"", "Reactome:R-HSA-140696 \"factor V -> factor Va + factor V activation peptide\"", "Reactome:R-HSA-140700 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)\"", "Reactome:R-HSA-140736 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140769 \"factor VII -> factor VIIa\"", "Reactome:R-HSA-140777 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)\"", "Reactome:R-HSA-140823 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140840 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B\"", "Reactome:R-HSA-140870 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin\"", "Reactome:R-HSA-141026 \"Activated protein C cleaves factor Va to factor Vi intermediate form\"", "Reactome:R-HSA-141040 \"Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C\"", "Reactome:R-HSA-1454843 \"E-cadherin degradation by MMP3, MMP7 and plasmin.\"", "Reactome:R-HSA-1474197 \"Collagen type II degradation by MMP1,3,8,13,PRSS2\"", "Reactome:R-HSA-1566962 \"Elastin degradation by elastin-degrading extracellular proteinases\"", "Reactome:R-HSA-1566979 \"Laminin-332 degradation by laminin-322 degrading extracellular proteinases\"", "Reactome:R-HSA-1566981 \"Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS\"", "Reactome:R-HSA-158137 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer\"", "Reactome:R-HSA-158164 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)\"", "Reactome:R-HSA-158300 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)\"", "Reactome:R-HSA-158311 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin\"", "Reactome:R-HSA-158313 \"factor XII -> factor XIIa\"", "Reactome:R-HSA-158333 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)\"", "Reactome:R-HSA-158419 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)\"", "Reactome:R-HSA-158744 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin\"", "Reactome:R-HSA-158747 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)\"", "Reactome:R-HSA-158750 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin\"", "Reactome:R-HSA-158766 \"fibrin multimer, crosslinked -> fibrin digestion products (plasmin)\"", "Reactome:R-HSA-158925 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)\"", "Reactome:R-HSA-158942 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-158982 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)\"", "Reactome:R-HSA-1592270 \"NID1 degradation by MMP1, 9, 12, ELANE\"", "Reactome:R-HSA-1592278 \"Autocatalytic activation of proMMP2\"", "Reactome:R-HSA-1592297 \"Full activation of MMP1\"", "Reactome:R-HSA-1592314 \"HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)\"", "Reactome:R-HSA-1592316 \"Initial activation of proMMP1\"", "Reactome:R-HSA-1592362 \"Activation of proMMP7 by MMP3\"", "Reactome:R-HSA-1592371 \"Initial activation of proMMP3\"", "Reactome:R-HSA-1592398 \"Activation of proMMP8\"", "Reactome:R-HSA-1592436 \"Initial activation of proMMP9 by MMPs\"", "Reactome:R-HSA-159728 \"Furin cleaves pro-prothrombin to prothrombin\"", "Reactome:R-HSA-159733 \"Furin cleaves pro-factor X to factor X\"", "Reactome:R-HSA-159771 \"Furin cleaves pro-protein C to protein C\"", "Reactome:R-HSA-159773 \"Furin cleaves pro-protein S to protein S\"", "Reactome:R-HSA-159796 \"Furin cleaves pro-factor IX to factor IX\"", "Reactome:R-HSA-159868 \"Furin cleaves pro-factor VII to factor VII\"", "Reactome:R-HSA-1602458 \"Activation of proMMP10\"", "Reactome:R-HSA-1602466 \"Activation of MT-MMPs by FURIN\"", "Reactome:R-HSA-1602473 \"Autocatalytic activation of MMP1\"", "Reactome:R-HSA-1602484 \"Activation of proMMP11 by FURIN\"", "Reactome:R-HSA-1602488 \"Initial activation of proMMP13 by plasmin and trypsin\"", "Reactome:R-HSA-1604359 \"Initial activation of proMMP2 by MMP1, 7\"", "Reactome:R-HSA-1604360 \"Initial activation of proMMP2 by MMP14\"", "Reactome:R-HSA-1604368 \"Autocatalytic activation of bound proMMP2\"", "Reactome:R-HSA-1604690 \"Activation of MMP9 intermediate form by MMPs\"", "Reactome:R-HSA-1604712 \"Initial activation of proMMP7 by trypsin\"", "Reactome:R-HSA-1604722 \"Activation of proMMP9 by proteases\"", "Reactome:R-HSA-1604731 \"Autocatalytic activation of MMP3\"", "Reactome:R-HSA-1604732 \"Autocatalytic activation of proMMP13\"", "Reactome:R-HSA-1604741 \"Initial activation of proMMP13 by MMP14 (MT1-MMP)\"", "Reactome:R-HSA-1604752 \"Initial activation of proMMP13 by MMP3\"", "Reactome:R-HSA-1604763 \"Autocatalytic activation of MMP7\"", "Reactome:R-HSA-163798 \"Furin cleaves pro-protein Z to protein Z\"", "Reactome:R-HSA-163843 \"Furin cleaves pro-GAS6 to GAS6\"", "Reactome:R-HSA-1655842 \"S1P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-166753 \"Conversion of C4 into C4a and C4b\"", "Reactome:R-HSA-166792 \"Conversion of C2 into C2a and C2b\"", "Reactome:R-HSA-166817 \"Cleavage of C3 by C3 convertases\"", "Reactome:R-HSA-170844 \"Latent TGF-beta-1 is cleaved by FURIN\"", "Reactome:R-HSA-171288 \"Cleavage of the viral Env gp160 precursor polyprotein\"", "Reactome:R-HSA-173626 \"Activation of C1r\"", "Reactome:R-HSA-173631 \"Activation of C1s\"", "Reactome:R-HSA-173680 \"Activation of C5\"", "Reactome:R-HSA-173745 \"Factor D cleaves C3(H2O)-bound Factor B\"", "Reactome:R-HSA-174551 \"Formation of alternative pathway C5 convertase\"", "Reactome:R-HSA-1799329 \"Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein\"", "Reactome:R-HSA-183122 \"Factor D cleaves C3b-bound Factor B\"", "Reactome:R-HSA-183130 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a\"", "Reactome:R-HSA-186785 \"PDGF-AA clevage by Furin\"", "Reactome:R-HSA-187020 \"Part of pro-beta-NGF is processed to mature beta-NGF\"", "Reactome:R-HSA-1912369 \"NOTCH precursor cleaved to form mature NOTCH\"", "Reactome:R-HSA-1912372 \"Fringe-modified Pre-NOTCH is cleaved by FURIN\"", "Reactome:R-HSA-2022411 \"Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)\"", "Reactome:R-HSA-2129357 \"Fibrillin C-terminal processing\"", "Reactome:R-HSA-2168923 \"Collagen type XVIII endostatin release\"", "Reactome:R-HSA-2168960 \"Collagen type XVII ectodomain shedding\"", "Reactome:R-HSA-2172405 \"Collagen type XXIII ectodomain shedding\"", "Reactome:R-HSA-2214330 \"Cleavage of collagen VII NC2 region by BMP1\"", "Reactome:R-HSA-2471621 \"Endostatin degradation by cathepsins\"", "Reactome:R-HSA-2471842 \"Collagen type XXV ectomain shedding\"", "Reactome:R-HSA-2482180 \"Collagen type VIII degradation by ELANE\"", "Reactome:R-HSA-2514772 \"Fibrillin-1 degradation by MMP3, CTSK, CTSL2\"", "Reactome:R-HSA-2514823 \"Fibrillin-1 degradation by ELANE\"", "Reactome:R-HSA-2534160 \"HSPG2 (perlecan) degradation by MMP13, CTSS\"", "Reactome:R-HSA-2534206 \"E-cadherin degradation by PS1:NCSTN (Gamma-secretase)\"", "Reactome:R-HSA-2534260 \"E-cadherin degradation by caspase-3 and calpain-1\"", "Reactome:R-HSA-265301 \"Corticotropin cleavage from POMC\"", "Reactome:R-HSA-3266557 \"Factor I cleaves iC3b\"", "Reactome:R-HSA-3785684 \"Fibronectin degradation by CTSG\"", "Reactome:R-HSA-3788061 \"Fibronectin degradation by ADAM8\"", "Reactome:R-HSA-381135 \"MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-381446 \"Thrombin proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381461 \"Plasmin proteolyzes IGF:IGFBP-3:ALS\"", "Reactome:R-HSA-381466 \"Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-3814820 \"HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1\"", "Reactome:R-HSA-381500 \"Cathepsin G proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381798 \"PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1\"", "Reactome:R-HSA-382061 \"Extracellular processing of novel PDGFs\"", "Reactome:R-HSA-3928657 \"MMP2,9 cleave EPHB\"", "Reactome:R-HSA-400459 \"Signal peptidase hydrolyzes preproGLP-1 to proGLP-1\"", "Reactome:R-HSA-400492 \"PCSK1 hydrolyzes proGIP to GIP\"", "Reactome:R-HSA-400496 \"Signal peptidase hydrolyzes preproGIP to proGIP\"", "Reactome:R-HSA-422021 \"PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin\"", "Reactome:R-HSA-422051 \"Cleavage of the signal peptide of Preproghrelin\"", "Reactome:R-HSA-5210912 \"Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5210935 \"Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5578783 \"CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)\"", "Reactome:R-HSA-5591040 \"Activated protein C cleaves Factor Va intermediate form for Factor Va\"", "Reactome:R-HSA-5607002 \"Activated protein C cleaves factor VIIIa\"", "Reactome:R-HSA-5691512 \"APEH hydrolyses NAc-Ser-protein\"", "Reactome:R-HSA-6800198 \"HPN heterodimer cleaves pro-MST1 to form MST1 dimer\"", "Reactome:R-HSA-6800200 \"HPN heterodimer cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6800299 \"HGFAC cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6801687 \"PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)\"", "Reactome:R-HSA-6807224 \"Furin cleaves pro-BGLAP to BGLAP\"", "Reactome:R-HSA-8849826 \"ST14 hydrolyzes and activates KLK5\"", "Reactome:R-HSA-8849857 \"KLK5 cleaves and activates CELA2\"", "Reactome:R-HSA-8850831 \"KLK5 cleaves and activates KLK8\"", "Reactome:R-HSA-8852716 \"Thrombin, ELANE cleave C5\"", "Reactome:R-HSA-8855825 \"HTRA1 hydrolyzes ACAN (Aggrecan)\"", "Reactome:R-HSA-8865275 \"PDGF-BB clevage by Furin\"", "Reactome:R-HSA-8865276 \"PDGF-AB clevage by Furin\"", "Reactome:R-HSA-8874145 \"MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874186 \"MBTPS1 (S1P) cleaves CREB3L4\"", "Reactome:R-HSA-8874204 \"MBTPS1 (S1P) cleaves CREB3\"", "Reactome:R-HSA-8874205 \"MBTPS1 (S1P) cleaves CREB3L2\"", "Reactome:R-HSA-8874206 \"MBTPS1 (S1P) cleaves CREB3L3\"", "Reactome:R-HSA-8874212 \"MBTPS1 (S1P) cleaves CREB3L1\"", "Reactome:R-HSA-9023178 \"PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))\"", "Reactome:R-HSA-9023196 \"PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)\"", "Reactome:R-HSA-9023626 \"DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023627 \"DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023632 \"DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9023633 \"DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9033490 \"TYSND1 cleaves PHYH\"", "Reactome:R-HSA-9033506 \"TYSND1 cleaves AGPS\"", "Reactome:R-HSA-9033515 \"TYSND1 cleaves ACOX1\"", "Reactome:R-HSA-9033520 \"TYSND1 cleaves TYSND1\"", "Reactome:R-HSA-9033524 \"TYSND1 cleaves SCP2\"", "Reactome:R-HSA-9033529 \"TYSND1 cleaves ACAA1\"", "Reactome:R-HSA-9033530 \"TYSND1 cleaves HSD17B4\"", "Reactome:R-HSA-9653249 \"Cleavage of factor XII variant by activated thrombin\"", "Reactome:R-HSA-9655046 \"Cleavage of FXII variant by KLKB1\"", "Reactome:R-HSA-9662786 \"FURIN cleaves ADAM17\"", "Reactome:R-HSA-9666383 \"F8 variant is not cleaved by thrombin\"", "Reactome:R-HSA-9668253 \"Hyperactivation of factor X by FVIIIa:FIXa R384L\"", "Reactome:R-HSA-9668365 \"FVIIIa variant:FIXa does not convert FX to the active FXa\"", "Reactome:R-HSA-9670874 \"FIXa variant:FVIIIa does not convert FX to the active FXa\"", "Reactome:R-HSA-9673223 \"FIX(29-461) variant is not activated (factor XIa catalyst)\"", "Reactome:R-HSA-9686710 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9686731 \"TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9694287 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9694661 \"TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9698988 \"Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid\"", "Reactome:R-HSA-9699007 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9708859 \"Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it\"", "Reactome:R-HSA-9710106 \"ELANE cleaves GSDMD\"", "Reactome:R-HSA-9710263 \"GZMB cleaves GSDME\"", "Reactome:R-HSA-976743 \"Factor I inactivates plasma Factor H-bound C3b\"", "Reactome:R-HSA-9769949 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage\"", "Reactome:R-HSA-9770187 \"S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion\"", "Reactome:R-HSA-977371 \"Factor I inactivates Factor H-boundC3b\"", "Reactome:R-HSA-977615 \"Factor I inactivates MCP/CR1-bound C4b/C3b\"", "Reactome:R-HSA-9829030 \"Nascent F signal peptide is cleaved at ER membrane\"", "Reactome:R-HSA-9829200 \"F0 is cleaved, releasing F1, F2, F(110-136)\"", "Reactome:R-HSA-9830805 \"Nascent sG localizes to ER lumen, gets glycosylated\"", "Reactome:R-HSA-9830882 \"Nascent G signal peptide is cleaved at ER membrane\"" ], "previous": [ "EC:3.4.21.-", "Reactome:R-HSA-114697 \"Activated thrombin (factor IIa) cleaves PAR3,4, activating them\"", "Reactome:R-HSA-1181152 \"Cleavage of NODAL proprotein\"", "Reactome:R-HSA-139893 \"Granzyme-B activates BID by cleavage\"", "Reactome:R-HSA-140599 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides\"", "Reactome:R-HSA-140664 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)\"", "Reactome:R-HSA-140696 \"factor V -> factor Va + factor V activation peptide\"", "Reactome:R-HSA-140700 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)\"", "Reactome:R-HSA-140736 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140769 \"factor VII -> factor VIIa\"", "Reactome:R-HSA-140777 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)\"", "Reactome:R-HSA-140823 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140840 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B\"", "Reactome:R-HSA-140870 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin\"", "Reactome:R-HSA-141026 \"Activated protein C cleaves factor Va to factor Vi intermediate form\"", "Reactome:R-HSA-141040 \"Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C\"", "Reactome:R-HSA-1454843 \"E-cadherin degradation by MMP3, MMP7 and plasmin.\"", "Reactome:R-HSA-1474197 \"Collagen type II degradation by MMP1,3,8,13,PRSS2\"", "Reactome:R-HSA-1566962 \"Elastin degradation by elastin-degrading extracellular proteinases\"", "Reactome:R-HSA-1566979 \"Laminin-332 degradation by laminin-322 degrading extracellular proteinases\"", "Reactome:R-HSA-1566981 \"Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS\"", "Reactome:R-HSA-158137 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer\"", "Reactome:R-HSA-158164 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)\"", "Reactome:R-HSA-158300 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)\"", "Reactome:R-HSA-158311 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin\"", "Reactome:R-HSA-158313 \"factor XII -> factor XIIa\"", "Reactome:R-HSA-158333 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)\"", "Reactome:R-HSA-158419 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)\"", "Reactome:R-HSA-158744 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin\"", "Reactome:R-HSA-158747 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)\"", "Reactome:R-HSA-158750 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin\"", "Reactome:R-HSA-158766 \"fibrin multimer, crosslinked -> fibrin digestion products (plasmin)\"", "Reactome:R-HSA-158925 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)\"", "Reactome:R-HSA-158942 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-158982 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)\"", "Reactome:R-HSA-1592270 \"NID1 degradation by MMP1, 9, 12, ELANE\"", "Reactome:R-HSA-1592278 \"Autocatalytic activation of proMMP2\"", "Reactome:R-HSA-1592297 \"Full activation of MMP1\"", "Reactome:R-HSA-1592314 \"HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)\"", "Reactome:R-HSA-1592316 \"Initial activation of proMMP1\"", "Reactome:R-HSA-1592362 \"Activation of proMMP7 by MMP3\"", "Reactome:R-HSA-1592371 \"Initial activation of proMMP3\"", "Reactome:R-HSA-1592398 \"Activation of proMMP8\"", "Reactome:R-HSA-1592436 \"Initial activation of proMMP9 by MMPs\"", "Reactome:R-HSA-159728 \"Furin cleaves pro-prothrombin to prothrombin\"", "Reactome:R-HSA-159733 \"Furin cleaves pro-factor X to factor X\"", "Reactome:R-HSA-159771 \"Furin cleaves pro-protein C to protein C\"", "Reactome:R-HSA-159773 \"Furin cleaves pro-protein S to protein S\"", "Reactome:R-HSA-159796 \"Furin cleaves pro-factor IX to factor IX\"", "Reactome:R-HSA-159868 \"Furin cleaves pro-factor VII to factor VII\"", "Reactome:R-HSA-1602458 \"Activation of proMMP10\"", "Reactome:R-HSA-1602466 \"Activation of MT-MMPs by FURIN\"", "Reactome:R-HSA-1602473 \"Autocatalytic activation of MMP1\"", "Reactome:R-HSA-1602484 \"Activation of proMMP11 by FURIN\"", "Reactome:R-HSA-1602488 \"Initial activation of proMMP13 by plasmin and trypsin\"", "Reactome:R-HSA-1604359 \"Initial activation of proMMP2 by MMP1, 7\"", "Reactome:R-HSA-1604360 \"Initial activation of proMMP2 by MMP14\"", "Reactome:R-HSA-1604368 \"Autocatalytic activation of bound proMMP2\"", "Reactome:R-HSA-1604690 \"Activation of MMP9 intermediate form by MMPs\"", "Reactome:R-HSA-1604712 \"Initial activation of proMMP7 by trypsin\"", "Reactome:R-HSA-1604722 \"Activation of proMMP9 by proteases\"", "Reactome:R-HSA-1604731 \"Autocatalytic activation of MMP3\"", "Reactome:R-HSA-1604732 \"Autocatalytic activation of proMMP13\"", "Reactome:R-HSA-1604741 \"Initial activation of proMMP13 by MMP14 (MT1-MMP)\"", "Reactome:R-HSA-1604752 \"Initial activation of proMMP13 by MMP3\"", "Reactome:R-HSA-1604763 \"Autocatalytic activation of MMP7\"", "Reactome:R-HSA-163798 \"Furin cleaves pro-protein Z to protein Z\"", "Reactome:R-HSA-163843 \"Furin cleaves pro-GAS6 to GAS6\"", "Reactome:R-HSA-1655842 \"S1P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-166753 \"Conversion of C4 into C4a and C4b\"", "Reactome:R-HSA-166792 \"Conversion of C2 into C2a and C2b\"", "Reactome:R-HSA-166817 \"Cleavage of C3 by C3 convertases\"", "Reactome:R-HSA-170844 \"Latent TGF-beta-1 is cleaved by FURIN\"", "Reactome:R-HSA-171288 \"Cleavage of the viral Env gp160 precursor polyprotein\"", "Reactome:R-HSA-173626 \"Activation of C1r\"", "Reactome:R-HSA-173631 \"Activation of C1s\"", "Reactome:R-HSA-173680 \"Activation of C5\"", "Reactome:R-HSA-173745 \"Factor D cleaves C3(H2O)-bound Factor B\"", "Reactome:R-HSA-174551 \"Formation of alternative pathway C5 convertase\"", "Reactome:R-HSA-1799329 \"Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein\"", "Reactome:R-HSA-183122 \"Factor D cleaves C3b-bound Factor B\"", "Reactome:R-HSA-183130 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a\"", "Reactome:R-HSA-186785 \"PDGF-AA clevage by Furin\"", "Reactome:R-HSA-187020 \"Part of pro-beta-NGF is processed to mature beta-NGF\"", "Reactome:R-HSA-1912369 \"NOTCH precursor cleaved to form mature NOTCH\"", "Reactome:R-HSA-1912372 \"Fringe-modified Pre-NOTCH is cleaved by FURIN\"", "Reactome:R-HSA-2022411 \"Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)\"", "Reactome:R-HSA-2129357 \"Fibrillin C-terminal processing\"", "Reactome:R-HSA-2168923 \"Collagen type XVIII endostatin release\"", "Reactome:R-HSA-2168960 \"Collagen type XVII ectodomain shedding\"", "Reactome:R-HSA-2172405 \"Collagen type XXIII ectodomain shedding\"", "Reactome:R-HSA-2214330 \"Cleavage of collagen VII NC2 region by BMP1\"", "Reactome:R-HSA-2471621 \"Endostatin degradation by cathepsins\"", "Reactome:R-HSA-2471842 \"Collagen type XXV ectomain shedding\"", "Reactome:R-HSA-2482180 \"Collagen type VIII degradation by ELANE\"", "Reactome:R-HSA-2514772 \"Fibrillin-1 degradation by MMP3, CTSK, CTSL2\"", "Reactome:R-HSA-2514823 \"Fibrillin-1 degradation by ELANE\"", "Reactome:R-HSA-2534160 \"HSPG2 (perlecan) degradation by MMP13, CTSS\"", "Reactome:R-HSA-2534206 \"E-cadherin degradation by PS1:NCSTN (Gamma-secretase)\"", "Reactome:R-HSA-2534260 \"E-cadherin degradation by caspase-3 and calpain-1\"", "Reactome:R-HSA-265301 \"Corticotropin cleavage from POMC\"", "Reactome:R-HSA-3266557 \"Factor I cleaves iC3b\"", "Reactome:R-HSA-3785684 \"Fibronectin degradation by CTSG\"", "Reactome:R-HSA-3788061 \"Fibronectin degradation by ADAM8\"", "Reactome:R-HSA-381135 \"MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-381446 \"Thrombin proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381461 \"Plasmin proteolyzes IGF:IGFBP-3:ALS\"", "Reactome:R-HSA-381466 \"Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-3814820 \"HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1\"", "Reactome:R-HSA-381500 \"Cathepsin G proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381798 \"PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1\"", "Reactome:R-HSA-382061 \"Extracellular processing of novel PDGFs\"", "Reactome:R-HSA-3928657 \"MMP2,9 cleave EPHB\"", "Reactome:R-HSA-400459 \"Signal peptidase hydrolyzes preproGLP-1 to proGLP-1\"", "Reactome:R-HSA-400492 \"PCSK1 hydrolyzes proGIP to GIP\"", "Reactome:R-HSA-400496 \"Signal peptidase hydrolyzes preproGIP to proGIP\"", "Reactome:R-HSA-422021 \"PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin\"", "Reactome:R-HSA-422051 \"Cleavage of the signal peptide of Preproghrelin\"", "Reactome:R-HSA-5210912 \"Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5210935 \"Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5578783 \"CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)\"", "Reactome:R-HSA-5591040 \"Activated protein C cleaves Factor Va intermediate form for Factor Va\"", "Reactome:R-HSA-5607002 \"Activated protein C cleaves factor VIIIa\"", "Reactome:R-HSA-5691512 \"APEH hydrolyses NAc-Ser-protein\"", "Reactome:R-HSA-6800198 \"HPN heterodimer cleaves pro-MST1 to form MST1 dimer\"", "Reactome:R-HSA-6800200 \"HPN heterodimer cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6800299 \"HGFAC cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6801687 \"PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)\"", "Reactome:R-HSA-6807224 \"Furin cleaves pro-BGLAP to BGLAP\"", "Reactome:R-HSA-8849826 \"ST14 hydrolyzes and activates KLK5\"", "Reactome:R-HSA-8849857 \"KLK5 cleaves and activates CELA2\"", "Reactome:R-HSA-8850831 \"KLK5 cleaves and activates KLK8\"", "Reactome:R-HSA-8852716 \"Thrombin, ELANE cleave C5\"", "Reactome:R-HSA-8855825 \"HTRA1 hydrolyzes ACAN (Aggrecan)\"", "Reactome:R-HSA-8865275 \"PDGF-BB clevage by Furin\"", "Reactome:R-HSA-8865276 \"PDGF-AB clevage by Furin\"", "Reactome:R-HSA-8874186 \"MBTPS1 (S1P) cleaves CREB3L4\"", "Reactome:R-HSA-8874204 \"MBTPS1 (S1P) cleaves CREB3\"", "Reactome:R-HSA-8874205 \"MBTPS1 (S1P) cleaves CREB3L2\"", "Reactome:R-HSA-8874206 \"MBTPS1 (S1P) cleaves CREB3L3\"", "Reactome:R-HSA-8874212 \"MBTPS1 (S1P) cleaves CREB3L1\"", "Reactome:R-HSA-9023178 \"PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))\"", "Reactome:R-HSA-9023196 \"PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)\"", "Reactome:R-HSA-9023626 \"DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023627 \"DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023632 \"DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9023633 \"DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9033490 \"TYSND1 cleaves PHYH\"", "Reactome:R-HSA-9033506 \"TYSND1 cleaves AGPS\"", "Reactome:R-HSA-9033515 \"TYSND1 cleaves ACOX1\"", "Reactome:R-HSA-9033520 \"TYSND1 cleaves TYSND1\"", "Reactome:R-HSA-9033524 \"TYSND1 cleaves SCP2\"", "Reactome:R-HSA-9033529 \"TYSND1 cleaves ACAA1\"", "Reactome:R-HSA-9033530 \"TYSND1 cleaves HSD17B4\"", "Reactome:R-HSA-9653249 \"Cleavage of factor XII variant by activated thrombin\"", "Reactome:R-HSA-9655046 \"Cleavage of FXII variant by KLKB1\"", "Reactome:R-HSA-9662786 \"FURIN cleaves ADAM17\"", "Reactome:R-HSA-9666383 \"F8 variant is not cleaved by thrombin\"", "Reactome:R-HSA-9668253 \"Hyperactivation of factor X by FVIIIa:FIXa R384L\"", "Reactome:R-HSA-9668365 \"FVIIIa variant:FIXa does not convert FX to the active FXa\"", "Reactome:R-HSA-9670874 \"FIXa variant:FVIIIa does not convert FX to the active FXa\"", "Reactome:R-HSA-9673223 \"FIX(29-461) variant is not activated (factor XIa catalyst)\"", "Reactome:R-HSA-9686710 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9686731 \"TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9694287 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9694661 \"TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9698988 \"Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid\"", "Reactome:R-HSA-9699007 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9708859 \"Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it\"", "Reactome:R-HSA-9710106 \"ELANE cleaves GSDMD\"", "Reactome:R-HSA-9710263 \"GZMB cleaves GSDME\"", "Reactome:R-HSA-976743 \"Factor I inactivates plasma Factor H-bound C3b\"", "Reactome:R-HSA-9769949 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage\"", "Reactome:R-HSA-9770187 \"S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion\"", "Reactome:R-HSA-977371 \"Factor I inactivates Factor H-boundC3b\"", "Reactome:R-HSA-977615 \"Factor I inactivates MCP/CR1-bound C4b/C3b\"" ] } } }, { "id": "GO:0004298", "name": "threonine-type endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.25.-", "Reactome:R-HSA-9818574 \"TASP1 cleaves KMT2A\"", "Reactome:R-HSA-9818577 \"TASP1 cleaves KMT2B\"" ], "previous": [ "EC:3.4.25.-" ] } } }, { "id": "GO:0004308", "name": "exo-alpha-sialidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.18", "MetaCyc:3.2.1.18-RXN", "Reactome:R-HSA-1605723 \"NEU2 cleaves GM3 to form LacCer (cytosol)\"", "Reactome:R-HSA-1605724 \"NEU1,4 hydrolyze PSAP(195-273):GM3:PE\"", "Reactome:R-HSA-1605768 \"NEU3 cleaves GM3 to form LacCer (plasma membrane)\"", "Reactome:R-HSA-168870 \"Neuraminidase enzymatic release from sialic acid\"", "Reactome:R-HSA-4084994 \"NEU3 hydrolyzes Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4084999 \"NEU1 hydrolyses Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4085029 \"NEU2 hydrolyzes Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4341669 \"Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-9638120 \"NEU4 hydrolyses Neu5Ac from glycoconjugates\"" ], "previous": [ "EC:3.2.1.18", "MetaCyc:3.2.1.18-RXN", "Reactome:R-HSA-1605723 \"Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)\"", "Reactome:R-HSA-1605724 \"Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)\"", "Reactome:R-HSA-1605768 \"Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)\"", "Reactome:R-HSA-168870 \"Neuraminidase enzymatic release from sialic acid\"", "Reactome:R-HSA-4084994 \"NEU3 hydrolyzes Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4084999 \"NEU1 hydrolyses Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4085029 \"NEU2 hydrolyzes Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-4341669 \"Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates\"", "Reactome:R-HSA-9638120 \"NEU4 hydrolyses Neu5Ac from glycoconjugates\"" ] } } }, { "id": "GO:0004317", "name": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R04462", "RHEA:41908" ], "previous": [ "KEGG_REACTION:R04462", "MetaCyc:4.2.1.61-RXN", "RHEA:41908" ] } } }, { "id": "GO:0004336", "name": "galactosylceramidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.46", "MetaCyc:GALACTOSYLCERAMIDASE-RXN", "Reactome:R-HSA-1606564 \"GALC hydrolyzes GalCer\"", "RHEA:14297" ], "previous": [ "EC:3.2.1.46", "MetaCyc:GALACTOSYLCERAMIDASE-RXN", "Reactome:R-HSA-1606564 \"Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide\"", "RHEA:14297" ] } } }, { "id": "GO:0004340", "name": "glucokinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.2", "MetaCyc:GLUCOKIN-RXN", "Reactome:R-HSA-5621888 \"Defective HK1 does not phosphorylate Glc to form G6P\"", "Reactome:R-HSA-5621918 \"Defective GCK does not phosphorylate Glc to form G6P\"", "Reactome:R-HSA-70420 \"HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P\"", "RHEA:17825" ], "previous": [ "EC:2.7.1.2", "MetaCyc:GLUCOKIN-RXN", "Reactome:R-HSA-5621888 \"Defective HK1 does not phosphorylate Glc to form G6P\"", "Reactome:R-HSA-5621918 \"Defective GCK does not phosphorylate Glc to form G6P\"", "Reactome:R-HSA-70420 \"HK1,2,3,GCK phosphorylate Glc to form G6P\"", "RHEA:17825" ] } } }, { "id": "GO:0004348", "name": "glucosylceramidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.45", "MetaCyc:GLUCOSYLCERAMIDASE-RXN", "Reactome:R-HSA-1605591 \"GBA1:SAPC hydrolyzes GlcCer\"", "Reactome:R-HSA-1861788 \"GBA2 hydrolyzes GlcCer (plasma membrane)\"", "Reactome:R-HSA-1861789 \"GBA3 hydrolyzes GlcCer (cytosol)\"", "RHEA:13269" ], "previous": [ "EC:3.2.1.45", "MetaCyc:GLUCOSYLCERAMIDASE-RXN", "Reactome:R-HSA-1605591 \"Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide\"", "Reactome:R-HSA-1861788 \"Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)\"", "Reactome:R-HSA-1861789 \"Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)\"", "RHEA:13269" ] } } }, { "id": "GO:0004482", "name": "mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.56", "MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN", "Reactome:R-HSA-77090 \"Methylation of GMP-cap by RNA Methyltransferase\"", "Reactome:R-HSA-9684016 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9684017 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684018 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694476 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694492 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694737 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"", "Reactome:R-HSA-9830848 \"L protein acts as a cap N7 methyltransferase to modify RSV mRNAs\"" ], "previous": [ "EC:2.1.1.56", "MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN", "Reactome:R-HSA-77090 \"Methylation of GMP-cap by RNA Methyltransferase\"", "Reactome:R-HSA-9684016 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9684017 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684018 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694476 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694492 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694737 \"nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"" ] } } }, { "id": "GO:0004483", "name": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.57", "MetaCyc:2.1.1.57-RXN", "Reactome:R-HSA-9684030 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9684032 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684033 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9694499 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694521 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694721 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"", "Reactome:R-HSA-9834003 \"L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs\"" ], "previous": [ "EC:2.1.1.57", "MetaCyc:2.1.1.57-RXN", "Reactome:R-HSA-9684030 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9684032 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684033 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9694499 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694521 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694721 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"" ] } } }, { "id": "GO:0004497", "name": "monooxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-143468 \"MEOS oxidizes ethanol to acetaldehyde\"", "Reactome:R-HSA-156526 \"CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-211882 \"CYP3A7 can 6beta-hydroxylate testosterone\"", "Reactome:R-HSA-211904 \"CYP4F12 18-hydroxylates ARA\"", "Reactome:R-HSA-211910 \"CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation\"", "Reactome:R-HSA-211919 \"CYP4F8 19-hydroxylates PGH2\"", "Reactome:R-HSA-211924 \"CYP4B1 12-hydroxylates ARA\"", "Reactome:R-HSA-211929 \"CYP2C19 5-hydroxylates omeprazole\"", "Reactome:R-HSA-211948 \"CYP3A4 can N-demethylate loperamide\"", "Reactome:R-HSA-211951 \"CYP1B1 4-hydroxylates EST17b\"", "Reactome:R-HSA-211959 \"CYP3A43 6b-hydroxylates TEST\"", "Reactome:R-HSA-211960 \"CYP2U1 19-hydroxylates ARA\"", "Reactome:R-HSA-211962 \"CYP4F11 16-hydroxylates 3OH-PALM\"", "Reactome:R-HSA-211968 \"CYP2W1 oxidises INDOL\"", "Reactome:R-HSA-211988 \"CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation\"", "Reactome:R-HSA-211991 \"Cyclophosphamide is 4-hydroxylated by CYP2B6\"", "Reactome:R-HSA-212004 \"CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation\"", "Reactome:R-HSA-212005 \"CYP2F1 dehydrogenates 3-methylindole\"", "Reactome:R-HSA-213175 \"CYP3A4,5 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-215526 \"CYP4F3 20-hydroxylates LTB4\"", "Reactome:R-HSA-2161795 \"Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)\"", "Reactome:R-HSA-2161814 \"Arachidonic acid is hydroxylated to 19-HETE by CYP(2)\"", "Reactome:R-HSA-2161890 \"Arachidonic acid is epoxidated to 5,6-EET by CYP(4)\"", "Reactome:R-HSA-2161899 \"Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)\"", "Reactome:R-HSA-2161940 \"Arachidonic acid is hydroxylated to 20-HETE by CYP(3)\"", "Reactome:R-HSA-2162191 \"DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase\"", "Reactome:R-HSA-217258 \"FMO2:FAD:Mg2+ S-oxidises MTZ\"", "Reactome:R-HSA-5423647 \"CYP2A13 oxidises AFM1 to AFM1E\"", "Reactome:R-HSA-5423664 \"CYP3A4,5 hydroxylates AFB1 to AFQ1\"", "Reactome:R-HSA-5423672 \"CYP1A2, 3A4 oxidise AFB1 to AFNBO\"", "Reactome:R-HSA-5423678 \"CYP1A2 hydroxylates AFB1 to AFM1\"", "Reactome:R-HSA-5602242 \"Defective CYP2U1 does not omega-hydroxylate ARA\"", "Reactome:R-HSA-5602272 \"Defective CYP4F22 does not 20-hydroxylate TrXA3\"", "Reactome:R-HSA-5602295 \"CYP4F22 20-hydroxylates TrXA3\"", "Reactome:R-HSA-5605147 \"Defective CYP1B1 does not 4-hydroxylate EST17b\"", "Reactome:R-HSA-5662662 \"Tyrosinase oxidises tyrosine to dopaquinone\"", "Reactome:R-HSA-5662692 \"Dopa is oxidized to dopaquinone by TYR\"", "Reactome:R-HSA-5663050 \"DHI and DHICA polymerize forming eumelanin\"", "Reactome:R-HSA-6786239 \"CYP4V2 omega-hydroxylates DHA to HDoHE\"", "Reactome:R-HSA-76354 \"Vinyl chloride is oxidized to 2-Chloroethylene oxide\"", "Reactome:R-HSA-76373 \"N-hydroxylation of 4-aminobiphenyl\"", "Reactome:R-HSA-76386 \"CYP1A2 S-demethylates 6MMP\"", "Reactome:R-HSA-76397 \"Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)\"", "Reactome:R-HSA-76416 \"Benzene is hydroxylated to phenol\"", "Reactome:R-HSA-76426 \"N-atom dealkylation of caffeine\"", "Reactome:R-HSA-76434 \"Dehalogenation of carbon tetrachloride to form a free radical\"", "Reactome:R-HSA-76456 \"O-atom dealkylation of dextromethorphan\"", "Reactome:R-HSA-76466 \"CYP4A11 12-hydroxylates DDCX\"", "Reactome:R-HSA-76472 \"Ethylene is oxidized to Ethylene oxide by CYP1A1\"", "Reactome:R-HSA-76475 \"Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide\"", "Reactome:R-HSA-8865107 \"MICAL1 produces NADP+, H2O2\"", "Reactome:R-HSA-9018874 \"CYP monooxygenates EPA to 18(S)-HpEPE\"", "Reactome:R-HSA-9027042 \"CPY4 -oxidises 14(S)-HDHA to MaR-L1\"", "Reactome:R-HSA-9027043 \"CYPs hydroxylate DHA to 14(R)-HDHA\"", "Reactome:R-HSA-9027044 \"CYP4 -oxidises 14(R)-HDHA to MaR-L2\"", "Reactome:R-HSA-9027302 \"CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA\"", "Reactome:R-HSA-9027321 \"CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA\"", "Reactome:R-HSA-9037761 \"CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1\"", "Reactome:R-HSA-9749986 \"CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA\"", "Reactome:R-HSA-9750016 \"CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA\"", "Reactome:R-HSA-9753285 \"CYP2E1 monooxygenates APAP to NAPQI\"", "Reactome:R-HSA-9756138 \"CYP3A4 monooxygenates ATVL to 2-OH-ATVL\"", "Reactome:R-HSA-9756162 \"CYP3A4 monooxygenates ATV to 4-OH-ATV\"", "Reactome:R-HSA-9756169 \"CYP3A4 monooxygenates ATV to 2-OH-ATV\"", "Reactome:R-HSA-9756180 \"CYP3A4 monooxygenates ATVL to 4-OH-ATVL\"" ], "previous": [ "Reactome:R-HSA-143468 \"MEOS oxidizes ethanol to acetaldehyde\"", "Reactome:R-HSA-156526 \"CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-211882 \"CYP3A7 can 6beta-hydroxylate testosterone\"", "Reactome:R-HSA-211904 \"CYP4F12 18-hydroxylates ARA\"", "Reactome:R-HSA-211910 \"CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation\"", "Reactome:R-HSA-211919 \"CYP4F8 19-hydroxylates PGH2\"", "Reactome:R-HSA-211924 \"CYP4B1 12-hydroxylates ARA\"", "Reactome:R-HSA-211929 \"CYP2C19 5-hydroxylates omeprazole\"", "Reactome:R-HSA-211948 \"CYP3A4 can N-demethylate loperamide\"", "Reactome:R-HSA-211951 \"CYP1B1 4-hydroxylates EST17b\"", "Reactome:R-HSA-211959 \"CYP3A43 6b-hydroxylates TEST\"", "Reactome:R-HSA-211960 \"CYP2U1 19-hydroxylates ARA\"", "Reactome:R-HSA-211962 \"CYP4F11 16-hydroxylates 3OH-PALM\"", "Reactome:R-HSA-211968 \"CYP2W1 oxidises INDOL\"", "Reactome:R-HSA-211988 \"CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation\"", "Reactome:R-HSA-211991 \"Cyclophosphamide is 4-hydroxylated by CYP2B6\"", "Reactome:R-HSA-212004 \"CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation\"", "Reactome:R-HSA-212005 \"CYP2F1 dehydrogenates 3-methylindole\"", "Reactome:R-HSA-213175 \"CYP3A4,5 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-215526 \"CYP4F3 20-hydroxylates LTB4\"", "Reactome:R-HSA-2161795 \"Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)\"", "Reactome:R-HSA-2161814 \"Arachidonic acid is hydroxylated to 19-HETE by CYP(2)\"", "Reactome:R-HSA-2161890 \"Arachidonic acid is epoxidated to 5,6-EET by CYP(4)\"", "Reactome:R-HSA-2161899 \"Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)\"", "Reactome:R-HSA-2161940 \"Arachidonic acid is hydroxylated to 20-HETE by CYP(3)\"", "Reactome:R-HSA-2162191 \"DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase\"", "Reactome:R-HSA-217258 \"FMO2:FAD:Mg2+ S-oxidises MTZ\"", "Reactome:R-HSA-5423647 \"CYP2A13 oxidises AFM1 to AFM1E\"", "Reactome:R-HSA-5423664 \"CYP3A4,5 hydroxylates AFB1 to AFQ1\"", "Reactome:R-HSA-5423672 \"CYP1A2, 3A4 oxidise AFB1 to AFNBO\"", "Reactome:R-HSA-5423678 \"CYP1A2 hydroxylates AFB1 to AFM1\"", "Reactome:R-HSA-5602242 \"Defective CYP2U1 does not omega-hydroxylate ARA\"", "Reactome:R-HSA-5602272 \"Defective CYP4F22 does not 20-hydroxylate TrXA3\"", "Reactome:R-HSA-5602295 \"CYP4F22 20-hydroxylates TrXA3\"", "Reactome:R-HSA-5605147 \"Defective CYP1B1 does not 4-hydroxylate EST17b\"", "Reactome:R-HSA-5662662 \"Tyrosinase oxidises tyrosine to dopaquinone\"", "Reactome:R-HSA-5662692 \"Dopa is oxidized to dopaquinone by TYR\"", "Reactome:R-HSA-5663050 \"DHI and DHICA polymerise forming eumelanin\"", "Reactome:R-HSA-6786239 \"CYP4V2 omega-hydroxylates DHA to HDoHE\"", "Reactome:R-HSA-76354 \"Vinyl chloride is oxidized to 2-Chloroethylene oxide\"", "Reactome:R-HSA-76373 \"N-hydroxylation of 4-aminobiphenyl\"", "Reactome:R-HSA-76386 \"CYP1A2 S-demethylates 6MMP\"", "Reactome:R-HSA-76397 \"Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)\"", "Reactome:R-HSA-76416 \"Benzene is hydroxylated to phenol\"", "Reactome:R-HSA-76426 \"N-atom dealkylation of caffeine\"", "Reactome:R-HSA-76434 \"Dehalogenation of carbon tetrachloride to form a free radical\"", "Reactome:R-HSA-76456 \"O-atom dealkylation of dextromethorphan\"", "Reactome:R-HSA-76466 \"CYP4A11 12-hydroxylates DDCX\"", "Reactome:R-HSA-76472 \"Ethylene is oxidized to Ethylene oxide by CYP1A1\"", "Reactome:R-HSA-76475 \"Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide\"", "Reactome:R-HSA-8865107 \"MICAL1 produces NADP+, H2O2\"", "Reactome:R-HSA-9018874 \"CYP monooxygenates EPA to 18(S)-HpEPE\"", "Reactome:R-HSA-9027042 \"CPY4 -oxidises 14(S)-HDHA to MaR-L1\"", "Reactome:R-HSA-9027043 \"CYPs hydroxylate DHA to 14(R)-HDHA\"", "Reactome:R-HSA-9027044 \"CYP4 -oxidises 14(R)-HDHA to MaR-L2\"", "Reactome:R-HSA-9027302 \"CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA\"", "Reactome:R-HSA-9027321 \"CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA\"", "Reactome:R-HSA-9037761 \"CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1\"", "Reactome:R-HSA-9749986 \"CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA\"", "Reactome:R-HSA-9750016 \"CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA\"", "Reactome:R-HSA-9753285 \"CYP2E1 monooxygenates APAP to NAPQI\"", "Reactome:R-HSA-9756138 \"CYP3A4 monooxygenates ATVL to 2-OH-ATVL\"", "Reactome:R-HSA-9756162 \"CYP3A4 monooxygenates ATV to 4-OH-ATV\"", "Reactome:R-HSA-9756169 \"CYP3A4 monooxygenates ATV to 2-OH-ATV\"", "Reactome:R-HSA-9756180 \"CYP3A4 monooxygenates ATVL to 4-OH-ATVL\"" ] } } }, { "id": "GO:0004525", "name": "ribonuclease III activity", "changes": { "xrefs": { "current": [ "EC:3.1.26.3", "MetaCyc:3.1.26.3-RXN", "Reactome:R-HSA-203862 \"Dicer cleaves pre-miRNA to yield duplex miRNA\"", "Reactome:R-HSA-203893 \"Microprocessor complex cleaves pri-miRNA to pre-miRNA\"", "Reactome:R-HSA-426464 \"Dicer cleaves double-stranded RNA to yield double-stranded siRNA\"", "Reactome:R-HSA-9708292 \"DICER1 cleaves tRNA\"", "Reactome:R-HSA-9708408 \"DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid\"", "Reactome:R-HSA-9820840 \"DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA\"" ], "previous": [ "EC:3.1.26.3", "MetaCyc:3.1.26.3-RXN", "Reactome:R-HSA-203862 \"Dicer cleaves pre-miRNA to yield duplex miRNA\"", "Reactome:R-HSA-203893 \"Microprocessor complex cleaves pri-miRNA to pre-miRNA\"", "Reactome:R-HSA-426464 \"Dicer cleaves double-stranded RNA to yield double-stranded siRNA\"", "Reactome:R-HSA-9708292 \"DICER1 cleaves tRNA\"", "Reactome:R-HSA-9708408 \"DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid\"" ] } } }, { "id": "GO:0004535", "name": "poly(A)-specific ribonuclease activity", "changes": { "xrefs": { "current": [ "EC:3.1.13.4", "MetaCyc:3.1.13.4-RXN", "Reactome:R-HSA-429955 \"CCR4-NOT complex deadenylates mRNA\"", "Reactome:R-HSA-429992 \"PARN deadenylates mRNA\"", "Reactome:R-HSA-430021 \"PAN2-PAN3 complex partially deadenylates mRNA\"", "Reactome:R-HSA-9822311 \"CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP\"", "Reactome:R-HSA-9822335 \"CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA\"" ], "previous": [ "EC:3.1.13.4", "MetaCyc:3.1.13.4-RXN", "Reactome:R-HSA-429955 \"CCR4-NOT complex deadenylates mRNA\"", "Reactome:R-HSA-429992 \"PARN deadenylates mRNA\"", "Reactome:R-HSA-430021 \"PAN2-PAN3 complex partially deadenylates mRNA\"" ] } } }, { "id": "GO:0004557", "name": "alpha-galactosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.22", "MetaCyc:ALPHAGALACTOSID-RXN", "Reactome:R-HSA-1605736 \"GLA hydrolyzes PSAP(195-273):Gb3Cer:PE\"", "Reactome:R-HSA-9841189 \"GLA hydrolyzes PSAP(195-273):Gal2Cer:PE\"" ], "previous": [ "EC:3.2.1.22", "MetaCyc:ALPHAGALACTOSID-RXN", "Reactome:R-HSA-1605736 \"Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers\"" ] } } }, { "id": "GO:0004563", "name": "beta-N-acetylhexosaminidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.52", "MetaCyc:3.2.1.52-RXN", "Reactome:R-HSA-1605595 \"bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3\"", "Reactome:R-HSA-1605632 \"bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE\"", "Reactome:R-HSA-1638053 \"HEXA cleaves the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-2105001 \"HEXA cleaves the terminal GalNAc from DS\"", "Reactome:R-HSA-2162225 \"HEXA cleaves the terminal GalNAc from small HA fragments\"", "Reactome:R-HSA-3656259 \"Defective HEXA does not cleave the terminal GalNAc from DS\"", "Reactome:R-HSA-3662344 \"Defective HEXB does not cleave the terminal GalNAc from DS\"", "Reactome:R-HSA-9035976 \"Defective HEXA does not cleave the terminall GalNAc from small HA fragments\"", "Reactome:R-HSA-9035978 \"Defective HEXA does not cleave the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-9035982 \"Defective HEXB does not cleave the terminal GalNAc from HA fragments\"", "Reactome:R-HSA-9035983 \"Defective HEXB does not cleave the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-9638075 \"HEXB cleaves the terminal GalNAc from DS\"", "Reactome:R-HSA-9638076 \"HEXB cleaves the terminal GalNAc from small HA fragments\"", "Reactome:R-HSA-9638078 \"HEXB cleaves the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-9840833 \"bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer\"", "Reactome:R-HSA-9840884 \"bHEXA,bHEXS hydrolyze GM2A:SM2\"" ], "previous": [ "EC:3.2.1.52", "MetaCyc:3.2.1.52-RXN", "Reactome:R-HSA-1605595 \"Hexosaminidase A cleaves GalNAc from GM2 to form GM3\"", "Reactome:R-HSA-1605632 \"Both hexosaminidase A and B can cleave GalNAc from globoside\"", "Reactome:R-HSA-1638053 \"HEXA cleaves the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-2105001 \"HEXA cleaves the terminal GalNAc from DS\"", "Reactome:R-HSA-2162225 \"HEXA cleaves the terminal GalNAc from small HA fragments\"", "Reactome:R-HSA-3656259 \"Defective HEXA does not cleave the terminal GalNAc from DS\"", "Reactome:R-HSA-3662344 \"Defective HEXB does not cleave the terminal GalNAc from DS\"", "Reactome:R-HSA-9035976 \"Defective HEXA does not cleave the terminall GalNAc from small HA fragments\"", "Reactome:R-HSA-9035978 \"Defective HEXA does not cleave the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-9035982 \"Defective HEXB does not cleave the terminal GalNAc from HA fragments\"", "Reactome:R-HSA-9035983 \"Defective HEXB does not cleave the terminal GalNAc from keratan sulfate\"", "Reactome:R-HSA-9638075 \"HEXB cleaves the terminal GalNAc from DS\"", "Reactome:R-HSA-9638076 \"HEXB cleaves the terminal GalNAc from small HA fragments\"", "Reactome:R-HSA-9638078 \"HEXB cleaves the terminal GalNAc from keratan sulfate\"" ] } } }, { "id": "GO:0004565", "name": "beta-galactosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.23", "MetaCyc:3.2.1.23-RXN", "MetaCyc:BGALACT-PWY", "Reactome:R-HSA-1605624 \"Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2\"", "Reactome:R-HSA-1606312 \"GLB1 hydrolyzes SapB/C:LacCer\"", "Reactome:R-HSA-1630306 \"GLB1 hydrolyses a glycosaminoglycan\"", "Reactome:R-HSA-1793217 \"Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase\"", "Reactome:R-HSA-2090079 \"GLB1 hydrolyses linker chain(2)\"", "Reactome:R-HSA-2265534 \"Defective GLB1 does not hydrolyse a glycosaminoglycan\"", "Reactome:R-HSA-9036061 \"Defective GLB1 does not hydrolyse linker chain(2)\"", "Reactome:R-HSA-9840795 \"Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2\"" ], "previous": [ "EC:3.2.1.23", "MetaCyc:3.2.1.23-RXN", "MetaCyc:BGALACT-PWY", "Reactome:R-HSA-1605624 \"Beta-galactosidase hydrolyses GM1 to GM2\"", "Reactome:R-HSA-1606312 \"Beta-galactosidase can also hydrolyse globosides to form cerebrosides\"", "Reactome:R-HSA-1630306 \"GLB1 hydrolyses a glycosaminoglycan\"", "Reactome:R-HSA-1793217 \"Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase\"", "Reactome:R-HSA-2090079 \"GLB1 hydrolyses linker chain(2)\"", "Reactome:R-HSA-2265534 \"Defective GLB1 does not hydrolyse a glycosaminoglycan\"", "Reactome:R-HSA-9036061 \"Defective GLB1 does not hydrolyse linker chain(2)\"" ] } } }, { "id": "GO:0004594", "name": "pantothenate kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.33", "MetaCyc:PANTOTHENATE-KIN-RXN", "Reactome:R-HSA-196857 \"PANK2 phosphorylates PanK\"", "Reactome:R-HSA-199203 \"PANK1/3 phosphorylate PanK\"", "RHEA:16373" ], "previous": [ "EC:2.7.1.33", "MetaCyc:PANTOTHENATE-KIN-RXN", "Reactome:R-HSA-196857 \"PANK2 phosphorylates PanK\"", "Reactome:R-HSA-199203 \"PANK1/3/4 phosphorylate PanK\"", "RHEA:16373" ] } } }, { "id": "GO:0004672", "name": "protein kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-156832 \"INF-gamma induced phosphorylation of L13a\"", "Reactome:R-HSA-937034 \"IRAK1 phosphorylates Pellino\"", "Reactome:R-HSA-9604606 \"Unknown kinase phosphorylates NICD4\"", "Reactome:R-HSA-9673284 \"GTP-bound RAC1 contributes to MAPK8 activation\"", "Reactome:R-HSA-9732753 \"JAK1-activated RAF1 phosphorylates MAPKs\"", "Reactome:R-HSA-975139 \"IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation\"", "Reactome:R-HSA-9833820 \"PKR dimer autophosphorylates\"", "Reactome:R-HSA-9835885 \"p-PKR dimer phosphorylates eIF2-alpha\"", "Reactome:R-HSA-9836159 \"p-PKR dimer phosphorylates DHX9\"", "Reactome:R-HSA-9836184 \"p-PKR dimer phosphorylates CDK1\"", "Reactome:R-HSA-9836322 \"p-PKR dimer phosphorylates MKK6\"", "Reactome:R-HSA-9836362 \"p-PKR dimer phosphorylates TP53 tetramer\"", "Reactome:R-HSA-9836383 \"p-PKR dimer phosphorylates ILF3:ILF2\"", "Reactome:R-HSA-9836404 \"p-PKR dimer phosphorylates MAPT\"", "Reactome:R-HSA-9836435 \"p-PKR dimer phosphorylates SNCA\"", "Reactome:R-HSA-9836449 \"p-PKR dimer phosphorylates HIV tat\"", "Reactome:R-HSA-9836515 \"p-PKR dimer phosphorylates PTPN2\"", "Reactome:R-HSA-9836617 \"p-PKR dimer phosphorylates SPHK1\"", "Reactome:R-HSA-9836664 \"p-PKR dimer phosphorylates PPP2R5A\"" ], "previous": [ "Reactome:R-HSA-156832 \"INF-gamma induced phosphorylation of L13a\"", "Reactome:R-HSA-937034 \"IRAK1 phosphorylates Pellino\"", "Reactome:R-HSA-9604606 \"Unknown kinase phosphorylates NICD4\"", "Reactome:R-HSA-9673284 \"GTP-bound RAC1 contributes to MAPK8 activation\"", "Reactome:R-HSA-975139 \"IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation\"" ] } } }, { "id": "GO:0004674", "name": "protein serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.1", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-451347 \"Activation of JNK by DSCAM\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"" ], "previous": [ "EC:2.7.11.1", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes\"", "Reactome:R-HSA-170087 \"CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes\"", "Reactome:R-HSA-170116 \"Myt-1 mediated phosphorylation of Cyclin A:Cdc2\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-400382 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-451347 \"Activation of JNK by DSCAM\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-S182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of Cdc25A at Ser-123 by Chk1\"", "Reactome:R-HSA-69608 \"Phosphorylation of Cdc25A at Ser-123 by Chk2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T125\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"" ] } } }, { "id": "GO:0004679", "name": "AMP-activated protein kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.11", "Reactome:R-HSA-1592244 \"AMPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-163691 \"Phosphorylation of ChREBP at Serine 556 by AMPK\"", "Reactome:R-HSA-200423 \"pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis\"", "Reactome:R-HSA-380927 \"p-AMPK phosphorylates TSC1:TSC2\"", "Reactome:R-HSA-447074 \"AMPK phosphorylates Raptor in the mTORC1 complex\"", "Reactome:R-HSA-5673768 \"p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex\"", "Reactome:R-HSA-6805470 \"AMPK phosphorylates TP53\"" ], "previous": [ "EC:2.7.11.11", "Reactome:R-HSA-1592244 \"AMPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-163691 \"Phosphorylation of ChREBP at Serine 568 by AMPK\"", "Reactome:R-HSA-200423 \"pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis\"", "Reactome:R-HSA-380927 \"p-AMPK phosphorylates TSC1:TSC2\"", "Reactome:R-HSA-447074 \"AMPK phosphorylates Raptor in the mTORC1 complex\"", "Reactome:R-HSA-5673768 \"p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex\"", "Reactome:R-HSA-6805470 \"AMPK phosphorylates TP53\"" ] } } }, { "id": "GO:0004691", "name": "cAMP-dependent protein kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.11", "Reactome:R-HSA-163672 \"Phosphorylation of ChREBP at Thr(653) by PKA\"", "Reactome:R-HSA-163676 \"Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA\"", "Reactome:R-HSA-163773 \"Phosphorylation of PF2K-Pase by PKA catalytic subunit\"", "Reactome:R-HSA-177275 \"PKA phosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-177284 \"PKA phosphorylates PDE4B\"", "Reactome:R-HSA-432232 \"Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)\"", "Reactome:R-HSA-5610717 \"PKA phosphorylates GLI2\"", "Reactome:R-HSA-5610720 \"PKA phosphorylates GLI3\"", "Reactome:R-HSA-5610741 \"PKA phosphorylates GLI1\"", "Reactome:R-HSA-5617179 \"PRKACA phosphorylates TNNI3\"", "Reactome:R-HSA-5617182 \"PRKACA phosphorylates PLN\"", "Reactome:R-HSA-5687088 \"PKA phosphorylates MAPKAPK5\"", "Reactome:R-HSA-913451 \"IL3RB is phosphorylated on Ser-585\"", "Reactome:R-HSA-9838321 \"PRKACA phosphorylates TFAM in the mitochondrial matrix\"" ], "previous": [ "EC:2.7.11.11", "Reactome:R-HSA-163672 \"Phosphorylation of ChREBP at Thr(666) by PKA\"", "Reactome:R-HSA-163676 \"Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA\"", "Reactome:R-HSA-163773 \"Phosphorylation of PF2K-Pase by PKA catalytic subunit\"", "Reactome:R-HSA-177275 \"PKA phosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-177284 \"PKA phosphorylates PDE4B\"", "Reactome:R-HSA-432232 \"Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)\"", "Reactome:R-HSA-5610717 \"PKA phosphorylates GLI2\"", "Reactome:R-HSA-5610720 \"PKA phosphorylates GLI3\"", "Reactome:R-HSA-5610741 \"PKA phosphorylates GLI1\"", "Reactome:R-HSA-5617179 \"PRKACA phosphorylates TNNI3\"", "Reactome:R-HSA-5617182 \"PRKACA phosphorylates PLN\"", "Reactome:R-HSA-5687088 \"PKA phosphorylates MAPKAPK5\"", "Reactome:R-HSA-913451 \"IL3RB is phosphorylated on Ser-585\"" ] } } }, { "id": "GO:0004697", "name": "diacylglycerol-dependent serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.13", "Reactome:R-HSA-1433508 \"PKC alpha interacts with and phosphorylates KIT\"", "Reactome:R-HSA-193703 \"IKKbeta is activated\"", "Reactome:R-HSA-198314 \"DAG stimulates protein kinase C-delta\"", "Reactome:R-HSA-2179413 \"Activated PKC-alpha activate MMP3\"", "Reactome:R-HSA-2730863 \"Phosphorylation of CARMA1 by PKC-theta\"", "Reactome:R-HSA-374664 \"Phosphorylation and activation of Ezrin\"", "Reactome:R-HSA-429698 \"PRKD1,2,3 phosphorylates CERT1-2\"", "Reactome:R-HSA-450533 \"PKCdelta phosphorylates HuR\"", "Reactome:R-HSA-450550 \"PKCalpha phosphorylates HuR\"", "Reactome:R-HSA-5138432 \"DVL2 is phosphorylated by PKC\"", "Reactome:R-HSA-5218805 \"PKC autophosphorylates\"", "Reactome:R-HSA-5218823 \"PKC phosphorylates sphingosine kinase 1\"", "Reactome:R-HSA-5229194 \"Depolymerization of lamin filaments after PKC-mediated phosphorylation\"", "Reactome:R-HSA-5623667 \"PDPK1 phosphorylates PKN1,2,3\"", "Reactome:R-HSA-5625784 \"PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters\"", "Reactome:R-HSA-5671749 \"p-T774-PKN1 phosphorylates CDC25C\"", "Reactome:R-HSA-74615 \"PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP\"", "Reactome:R-HSA-751040 \"PKC phosphorylates G alpha (z)\"", "Reactome:R-HSA-8932284 \"PKC phosphorylates NFE2L2\"", "Reactome:R-HSA-8934446 \"Activated PKC phosphorylates SHC1\"", "Reactome:R-HSA-9010681 \"PKC phosphorylates ROBO3.1\"", "Reactome:R-HSA-9021357 \"PRKCI phosphorylates ELF3\"", "Reactome:R-HSA-909552 \"Phosphorylation of STAT1 at Ser727\"", "Reactome:R-HSA-927889 \"SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)\"", "Reactome:R-HSA-9626817 \"PKC phosphorylates NCF1\"", "Reactome:R-HSA-9632858 \"PRKCZ autophosphorylates downstream of estrogen stimulation\"", "Reactome:R-HSA-9796053 \"PRKCI phosphorylates NFE2L2\"" ], "previous": [ "EC:2.7.11.13", "Reactome:R-HSA-1433508 \"PKC alpha interacts with and phosphorylates KIT\"", "Reactome:R-HSA-193703 \"IKKbeta is activated\"", "Reactome:R-HSA-198314 \"DAG stimulates protein kinase C-delta\"", "Reactome:R-HSA-2179413 \"Activated PKC-alpha activate MMP3\"", "Reactome:R-HSA-2730863 \"Phosphorylation of CARMA1 by PKC-theta\"", "Reactome:R-HSA-374664 \"Phosphorylation and activation of Ezrin\"", "Reactome:R-HSA-429698 \"PRKD1,2,3 phosphorylates CERT1-2\"", "Reactome:R-HSA-450533 \"PKCdelta phosphorylates HuR\"", "Reactome:R-HSA-450550 \"PKCalpha phosphorylates HuR\"", "Reactome:R-HSA-5138432 \"DVL2 is phosphorylated by PKC\"", "Reactome:R-HSA-5218805 \"PKC autophosphorylates\"", "Reactome:R-HSA-5218823 \"PKC phosphorylates sphingosine kinase 1\"", "Reactome:R-HSA-5229194 \"Depolymerization of lamin filaments after PKC-mediated phosphorylation\"", "Reactome:R-HSA-5623667 \"PDPK1 phosphorylates PKN1,2,3\"", "Reactome:R-HSA-5625784 \"PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters\"", "Reactome:R-HSA-5671749 \"p-T774-PKN1 phosphorylates CDC25C\"", "Reactome:R-HSA-74615 \"PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP\"", "Reactome:R-HSA-751040 \"PKC phosphorylates G alpha (z)\"", "Reactome:R-HSA-8932284 \"PKC phosphorylates NFE2L2\"", "Reactome:R-HSA-8934446 \"Activated PKC phosphorylates SHC1\"", "Reactome:R-HSA-9010681 \"PKC phosphorylates ROBO3.1\"", "Reactome:R-HSA-9021357 \"PRKCI phosphorylates ELF3\"", "Reactome:R-HSA-909552 \"Phosphorylation of STAT1 at Ser727\"", "Reactome:R-HSA-927889 \"SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)\"", "Reactome:R-HSA-9626817 \"PKC phosphorylates NCF1\"", "Reactome:R-HSA-9632858 \"PRKCZ autophosphorylates downstream of estrogen stimulation\"" ] } } }, { "id": "GO:0004698", "name": "calcium,diacylglycerol-dependent serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-114683 \"Phosphorylation of Platelet Sec-1\"", "Reactome:R-HSA-114684 \"Phosphorylation of Syntaxin-4\"", "Reactome:R-HSA-416639 \"Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites\"", "Reactome:R-HSA-421007 \"Endocytosis of Ca impermeable AMPA receptors\"", "Reactome:R-HSA-8986937 \"MECP2 is phosphorylated at T308\"", "Reactome:R-HSA-9005561 \"Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308\"" ], "previous": [ "Reactome:R-HSA-114683 \"Phosphorylation of Platelet Sec-1\"", "Reactome:R-HSA-114684 \"Phosphorylation of Syntaxin-4\"", "Reactome:R-HSA-416639 \"Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites\"", "Reactome:R-HSA-421007 \"Endocytosis of Ca impermeable AMPA receptors\"" ] } } }, { "id": "GO:0004713", "name": "protein tyrosine kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-112333 \"SRC autophosphorylation is positively regulated by InlA-bound CDH1\"", "Reactome:R-HSA-114600 \"Fyn/Lyn-mediated phosphorylation of FcR1 gamma\"", "Reactome:R-HSA-1168394 \"STAT5 tyrosine phosphorylation\"", "Reactome:R-HSA-1169421 \"Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers\"", "Reactome:R-HSA-1225952 \"Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1225960 \"Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1247844 \"Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1248655 \"Trans-autophosphorylation of EGFRvIII mutant dimers\"", "Reactome:R-HSA-1248694 \"Trans-autophosphorylation of ERBB2 homodimer\"", "Reactome:R-HSA-1250195 \"SHC1 phosphorylation by ERBB2 heterodimers\"", "Reactome:R-HSA-1250315 \"Trans-autophosphorylation of ERBB4 homodimers\"", "Reactome:R-HSA-1250348 \"Phosphorylation of SHC1 by ERBB4 homodimers\"", "Reactome:R-HSA-1251922 \"PLCG1 phosphorylation by p-EGFR:p-ERBB2\"", "Reactome:R-HSA-1295540 \"IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5\"", "Reactome:R-HSA-1295609 \"SRC phosphorylates SPRY2 on Y55 and Y227\"", "Reactome:R-HSA-1307963 \"Autocatalytic phosphorylation of BetaKlotho-bound FGFR4\"", "Reactome:R-HSA-1433418 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-1433454 \"Phosphorylation of GAB2 by SFKs\"", "Reactome:R-HSA-1433488 \"Phosphorylation of SHP2 by SFKs\"", "Reactome:R-HSA-1433506 \"Phosphorylation of APS\"", "Reactome:R-HSA-1433542 \"Phosphorylation and activation of VAV1\"", "Reactome:R-HSA-1470009 \"Phosphorylation of STATs\"", "Reactome:R-HSA-1472121 \"Phosphorylation of p-KIT on Y900 by Src kinases\"", "Reactome:R-HSA-1524186 \"Phosphorylation of PLCgamma by PDGFR\"", "Reactome:R-HSA-1671691 \"PRLR-bound STAT5 is phosphorylated\"", "Reactome:R-HSA-170070 \"Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170156 \"Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170991 \"SRC-1 autophosphorylates\"", "Reactome:R-HSA-171011 \"Binding and activation of MAP Kinase\"", "Reactome:R-HSA-174164 \"Phosphorylation of Cyclin A:Cdk2 at Tyr 15\"", "Reactome:R-HSA-177934 \"EGFR autophosphorylation\"", "Reactome:R-HSA-177937 \"Phosphorylation of EGFR by SRC kinase\"", "Reactome:R-HSA-182969 \"Phosphorylation of CBL (EGFR:CBL)\"", "Reactome:R-HSA-183058 \"Phosphorylation of CBL (EGFR:GRB2:CBL)\"", "Reactome:R-HSA-1839065 \"Phosphorylation of cytosolic FGFR1 fusion dimers\"", "Reactome:R-HSA-1839067 \"Phosphorylation of BCR moiety of BCR-FGFR1\"", "Reactome:R-HSA-1839098 \"Activated FGFR1 mutants and fusions phosphorylate PLCG1\"", "Reactome:R-HSA-1839110 \"p-BCR-p-FGFR1 phosphorylates GAB2\"", "Reactome:R-HSA-1839112 \"Phosphorylation of STAT5 by cytosolic FGFR1 fusions\"", "Reactome:R-HSA-186786 \"Autophosphorylation of PDGF beta receptors\"", "Reactome:R-HSA-1888198 \"FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3\"", "Reactome:R-HSA-190326 \"Autocatalytic phosphorylation of FGFR4\"", "Reactome:R-HSA-190385 \"Autocatalytic phosphorylation of FGFR3b\"", "Reactome:R-HSA-190388 \"Autocatalytic phosphorylation of FGFR3c\"", "Reactome:R-HSA-190408 \"Autocatalytic phosphorylation of FGFR2b\"", "Reactome:R-HSA-190413 \"Autocatalytic phosphorylation of FGFR2c\"", "Reactome:R-HSA-190427 \"Autocatalytic phosphorylation of FGFR1b\"", "Reactome:R-HSA-190429 \"Autocatalytic phosphorylation of FGFR1c\"", "Reactome:R-HSA-191062 \"Autocatalytic phosphorylation of Klotho-bound FGFR1c\"", "Reactome:R-HSA-191636 \"Phosphorylation of Cx43 by c-src\"", "Reactome:R-HSA-1963581 \"Trans-autophosphorylation of p-Y877-ERBB2 heterodimers\"", "Reactome:R-HSA-1963582 \"Trans-autophosphorylation of ERBB2 heterodimers\"", "Reactome:R-HSA-1963586 \"SRC family kinases phosphorylate ERBB2\"", "Reactome:R-HSA-1982066 \"Ligand-independent phosphorylation of overexpressed FGFR1\"", "Reactome:R-HSA-2012073 \"Autocatalytic phosphorylation of FGFR3c P250R mutant\"", "Reactome:R-HSA-2012082 \"Autocatalytic phosphorylation of FGFR3 cysteine mutants\"", "Reactome:R-HSA-2012087 \"Autocatalytic phosphorylation of FGFR4 Y367C mutant\"", "Reactome:R-HSA-201521 \"ALK autophosphorylation\"", "Reactome:R-HSA-202165 \"Phosphorylation of ITAM motifs in CD3 complexes\"", "Reactome:R-HSA-202168 \"Phosphorylation of ZAP-70 by Lck\"", "Reactome:R-HSA-202174 \"Activation of ZAP-70\"", "Reactome:R-HSA-202216 \"Phosphorylation of SLP-76\"", "Reactome:R-HSA-202233 \"Inactivation of Lck by Csk\"", "Reactome:R-HSA-202245 \"Phosphorylation of TBSMs in LAT\"", "Reactome:R-HSA-202248 \"Phosphorylation of PLC-gamma1\"", "Reactome:R-HSA-202291 \"Activation of Lck\"", "Reactome:R-HSA-202307 \"Change of PKC theta conformation\"", "Reactome:R-HSA-2023455 \"Autocatalytic phosphorylation of FGFR1c P252X mutant dimers\"", "Reactome:R-HSA-2023460 \"Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity\"", "Reactome:R-HSA-2029268 \"Phosphorylation and activation of PLCG\"", "Reactome:R-HSA-2029449 \"Phosphorylation of SYK by Src kinases\"", "Reactome:R-HSA-2029453 \"Phosphorylation of VAV\"", "Reactome:R-HSA-2029459 \"Sequestering and phosphorylation Fc gamma receptors in the lipid rafts\"", "Reactome:R-HSA-2029984 \"Autocatalytic phosphorylation of FGFR2 ligand-independent mutants\"", "Reactome:R-HSA-2029989 \"Autocatalytic phosphorylation of overexpressed FGFR2 variants\"", "Reactome:R-HSA-2033485 \"Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2033486 \"Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033488 \"Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033490 \"Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2038387 \"Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants\"", "Reactome:R-HSA-2038944 \"Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity\"", "Reactome:R-HSA-205289 \"Autophosphorylation of KIT\"", "Reactome:R-HSA-210291 \"Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src\"", "Reactome:R-HSA-210872 \"Trans-phosphorylation of Tie2\"", "Reactome:R-HSA-212710 \"EGFR activates PLC-gamma1 by phosphorylation\"", "Reactome:R-HSA-2130194 \"ABL phosphorylates WAVEs\"", "Reactome:R-HSA-2197698 \"Src phosphorylate WASP,N-WASP\"", "Reactome:R-HSA-2201322 \"TIRAP is phosphorylated by BTK\"", "Reactome:R-HSA-2395412 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2395439 \"Phosphorylation of DAP12\"", "Reactome:R-HSA-2395801 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2396594 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2404193 \"IGF1R phosphorylates SHC1\"", "Reactome:R-HSA-2404199 \"IGF1,2:IGF1R autophosphorylates\"", "Reactome:R-HSA-2424484 \"Phosphorylation of BTK by p-SYK\"", "Reactome:R-HSA-2424486 \"Phosphorylation and activation of VAV2/VAV3 by SYK\"", "Reactome:R-HSA-2424487 \"Phosphorylation of PLC-gamma by p-BTK/p-SYK\"", "Reactome:R-HSA-2428926 \"IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4\"", "Reactome:R-HSA-2454208 \"Phosphorylation of beta and gamma subunits by LYN\"", "Reactome:R-HSA-2454239 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2586553 \"JAK2 Phosphorylates LEPR\"", "Reactome:R-HSA-2586555 \"JAK2 Autophosphorylates in Response to Leptin\"", "Reactome:R-HSA-2671742 \"JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin\"", "Reactome:R-HSA-2671829 \"JAK2 Phosphorylates STAT5 in Response to Leptin\"", "Reactome:R-HSA-2671850 \"JAK2 Phosphoryates STAT3 in Response to Leptin\"", "Reactome:R-HSA-2730833 \"Phosphorylation of TEC kinases by p-SYK\"", "Reactome:R-HSA-2730843 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2730851 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2730858 \"Autophosphorylation of BTK/ITK\"", "Reactome:R-HSA-2730860 \"Phosphorylation of GAB2 by SYK/FYN\"", "Reactome:R-HSA-2730862 \"Autophosphorylation of LYN kinase\"", "Reactome:R-HSA-2730882 \"Phosphorylation of PKC-theta\"", "Reactome:R-HSA-2730884 \"Phosphorylation of NTAL by p-SYK/Lyn\"", "Reactome:R-HSA-2730886 \"Phosphorylation of SHC by SYK kinase\"", "Reactome:R-HSA-2730888 \"Phosphorylation of PLC-gamma\"", "Reactome:R-HSA-3215391 \"PRMT5 is tyrosine phosphorylated by JAK2 V617F\"", "Reactome:R-HSA-354073 \"Autophosphorylation of PTK2 at Y397\"", "Reactome:R-HSA-354124 \"Phosphorylation of pPTK2 by SRC\"", "Reactome:R-HSA-372693 \"Phosphorylation of BCAR1 by SRC-PTK2 complex\"", "Reactome:R-HSA-373747 \"Phosphorylation of nephrin by FYN\"", "Reactome:R-HSA-373750 \"SEMA4D interacts with Plexin-B1:ErbB2\"", "Reactome:R-HSA-374701 \"Phosphorylation of DCC by Fyn\"", "Reactome:R-HSA-377640 \"Autophosphorylation of SRC\"", "Reactome:R-HSA-380780 \"Activation of Src\"", "Reactome:R-HSA-388831 \"Phosphorylation of CD28\"", "Reactome:R-HSA-388833 \"Phosphorylation of CTLA-4\"", "Reactome:R-HSA-389083 \"Autophosphorylation of PDGF alpha receptors\"", "Reactome:R-HSA-389086 \"Autophosphorylation of PDGF alpha/beta receptors\"", "Reactome:R-HSA-389159 \"CSF1R trans-autophosphorylates on multiple tyrosine and serine residues\"", "Reactome:R-HSA-389354 \"Activation of Vav1\"", "Reactome:R-HSA-389762 \"Phosphorylation of PD-1\"", "Reactome:R-HSA-391156 \"Phosphorylation of ITIM motif in SIRP alpha\"", "Reactome:R-HSA-391865 \"Recruitment of FAK to NCAM1:Fyn in lipid rafts\"", "Reactome:R-HSA-391866 \"Phosphorylation of FAK by Src kinase\"", "Reactome:R-HSA-391871 \"Autophosphorylation of NCAM1 bound Fyn\"", "Reactome:R-HSA-3928578 \"EPH receptors autophosphorylate\"", "Reactome:R-HSA-3928580 \"SFKs phosphorylate EFNBs\"", "Reactome:R-HSA-3928583 \"FYN phosphorylates NMDAR2B\"", "Reactome:R-HSA-3928594 \"SFKs phosphorylate GIT1\"", "Reactome:R-HSA-3928604 \"SFKs phosphorylate VAV2,3\"", "Reactome:R-HSA-3928610 \"PTK2 autophosphorylates at Y397\"", "Reactome:R-HSA-3928627 \"EPHB phosphorylates TIAM1\"", "Reactome:R-HSA-3928648 \"SFKs phosphorylate NGEF\"", "Reactome:R-HSA-399934 \"Phosphorylation of Plexin-A\"", "Reactome:R-HSA-399946 \"Recruitment and activation of Cdk5\"", "Reactome:R-HSA-399947 \"Tyrosine phosphorylation of CRMPs by Fes\"", "Reactome:R-HSA-4093332 \"p-EPHB phosphorylates SDC2\"", "Reactome:R-HSA-418163 \"Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)\"", "Reactome:R-HSA-418859 \"Phosphorylation of Unc5C\"", "Reactome:R-HSA-418872 \"Phosphorylation of FADK1\"", "Reactome:R-HSA-419646 \"SEMA4D interacts with Plexin-B1:Met\"", "Reactome:R-HSA-428888 \"Phosphorylation of ROBO1 by ABL kinase\"", "Reactome:R-HSA-429441 \"SYK activation by SRC\"", "Reactome:R-HSA-429449 \"Syk activation leads to SLP-76 activation\"", "Reactome:R-HSA-432129 \"FGR binds and phosphorylates LRP8\"", "Reactome:R-HSA-434836 \"Syk/Lck phosphorylate LAT\"", "Reactome:R-HSA-4420117 \"VEGFR2 autophosphorylates\"", "Reactome:R-HSA-4420121 \"SFKs phosphorylate PLCG1\"", "Reactome:R-HSA-4420128 \"SRC-1 phosphorylates SHB\"", "Reactome:R-HSA-4420206 \"Phosphorylation of SRC-1\"", "Reactome:R-HSA-443817 \"Phosphorylation of L1 by EPHB2\"", "Reactome:R-HSA-445076 \"Phosphorylation of Y1229 in L1\"", "Reactome:R-HSA-445084 \"Phosphorylation of L1 by SRC\"", "Reactome:R-HSA-445085 \"Phosphorylation of VAV2\"", "Reactome:R-HSA-445091 \"Phosphorylation of Neurofascin\"", "Reactome:R-HSA-451942 \"Within the IL-2R complex JAK3 phosphorylates JAK1\"", "Reactome:R-HSA-452097 \"Recruited STAT5 is phosphorylated\"", "Reactome:R-HSA-452100 \"SHC1 bound to IL2 receptor is phosphorylated\"", "Reactome:R-HSA-452122 \"JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB\"", "Reactome:R-HSA-508282 \"SYK is a substrate for JAK1\"", "Reactome:R-HSA-5218640 \"SRC-1 phosphorylates p-Y397-PTK2\"", "Reactome:R-HSA-5218642 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-5218806 \"FYN autophosphorylates\"", "Reactome:R-HSA-5218809 \"PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118\"", "Reactome:R-HSA-5218812 \"FYN phosphorylates PAK2\"", "Reactome:R-HSA-5218820 \"Src kinases phosphorylate VAV\"", "Reactome:R-HSA-5218828 \"PTK2/SRC-1 phosphorylates BCAR1\"", "Reactome:R-HSA-5218830 \"SRC-1 phosphorylates PTK2-beta\"", "Reactome:R-HSA-5218851 \"p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407\"", "Reactome:R-HSA-5357429 \"AXL autophosphorylates on Y779 and Y821\"", "Reactome:R-HSA-5607745 \"1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG\"", "Reactome:R-HSA-5607750 \"SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan\"", "Reactome:R-HSA-5621355 \"LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG\"", "Reactome:R-HSA-5621363 \"SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2\"", "Reactome:R-HSA-5621370 \"SYK autophosphorylates\"", "Reactome:R-HSA-5624486 \"SFKs phosphorylates RAF1 on Y340,Y341\"", "Reactome:R-HSA-5637795 \"Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant\"", "Reactome:R-HSA-5637796 \"Phosphorylation of SHC1 by p-5Y-EGFRvIII\"", "Reactome:R-HSA-5654147 \"Activated FGFR2 phosphorylates PLCG1\"", "Reactome:R-HSA-5654149 \"Activated FGFR1 phosphorylates PLCG1\"", "Reactome:R-HSA-5654151 \"Activated FGFR4 phosphorylates PLCG1\"", "Reactome:R-HSA-5654222 \"Activated FGFR3 phosphorylates PLCG1\"", "Reactome:R-HSA-5654397 \"Activated FGFR2 phosphorylates FRS2\"", "Reactome:R-HSA-5654407 \"Activated FGFR2 phosphorylates SHC1\"", "Reactome:R-HSA-5654408 \"Activated FGFR3 phosphorylates FRS2\"", "Reactome:R-HSA-5654418 \"Activated FGFR4 phosphorylates FRS2\"", "Reactome:R-HSA-5654428 \"Activated FGFR4 phosphorylates SHC1\"", "Reactome:R-HSA-5654545 \"Ligand-independent phosphorylation of overexpressed FGFR1c\"", "Reactome:R-HSA-5654575 \"Activated FGFR1 phosphorylates FRS2\"", "Reactome:R-HSA-5654578 \"Activated FGFR1 phosphorylates FRS3\"", "Reactome:R-HSA-5654582 \"Activated FGFR1 phosphorylates SHC1\"", "Reactome:R-HSA-5654587 \"Activated FGFR1:p-FRS phosphorylates PPTN11\"", "Reactome:R-HSA-5654605 \"Activated FGFR2 phosphorylates FRS3\"", "Reactome:R-HSA-5654607 \"Activated FGFR2 phosphorylates PPTN11\"", "Reactome:R-HSA-5654628 \"Activated FGFR3 phosphorylates FRS3\"", "Reactome:R-HSA-5654631 \"Activated FGFR3 phosphorylates PPTN11\"", "Reactome:R-HSA-5654634 \"Activated FGFR3 phosphorylates SHC1\"", "Reactome:R-HSA-5654653 \"Activated FGFR4 phosphorylates FRS3\"", "Reactome:R-HSA-5654655 \"Activated FGFR4 phosphorylates PPTN11\"", "Reactome:R-HSA-5655243 \"Activated FGFR3 point and translocation mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655268 \"Activated FGFR2 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655270 \"Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655278 \"Activated FGFR1 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655284 \"Activated FGFR4 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655301 \"Activated FGFR2 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655341 \"Activated FGFR4 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5683930 \"WICH phosphorylates H2AFX on Y142\"", "Reactome:R-HSA-5686587 \"ABL1 phosphorylates RAD52\"", "Reactome:R-HSA-5690702 \"LYN phosphorylates CD22\"", "Reactome:R-HSA-6784006 \"STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2\"", "Reactome:R-HSA-6784319 \"JAK1,TYK2 phosphorylate JAK1,TYK2\"", "Reactome:R-HSA-6790087 \"HVEM induses BTLA phosphorylation\"", "Reactome:R-HSA-6806974 \"MET dimers autophosphorylate\"", "Reactome:R-HSA-68954 \"Mcm2-7 is phosphorylated by DDK\"", "Reactome:R-HSA-69195 \"Phosphorylation of Cyclin E:CDK2 complexes by WEE1\"", "Reactome:R-HSA-873918 \"Transphosphorylation of JAK1\"", "Reactome:R-HSA-873919 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-873922 \"Phosphorylation of STAT1 by JAK kinases\"", "Reactome:R-HSA-873924 \"Phosphorylation of IFNGR1 by JAK kinases\"", "Reactome:R-HSA-879907 \"Tyrosine kinases phosphorylate the receptor\"", "Reactome:R-HSA-879909 \"Activation of STAT5a/b by JAK2\"", "Reactome:R-HSA-879925 \"SHC1 bound to the common beta chain becomes tyrosine phosphorylated\"", "Reactome:R-HSA-8847977 \"FRK phosphorylates PTEN\"", "Reactome:R-HSA-8848005 \"ERBB2 promotes PTK6 autophosphorylation\"", "Reactome:R-HSA-8848077 \"PTK6 phosphorylates STAP2\"", "Reactome:R-HSA-8848124 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-8848436 \"PTK6 phosphorylates CDKN1B\"", "Reactome:R-HSA-8848606 \"PTK6 phosphorylates PXN\"", "Reactome:R-HSA-8848726 \"PTK6 phosphorylates BCAR1\"", "Reactome:R-HSA-8848758 \"PTK6 phosphorylates AKT1\"", "Reactome:R-HSA-8848776 \"PTK6 phosphorylates DOK1\"", "Reactome:R-HSA-8848818 \"PTK6 phosphorylates CBL\"", "Reactome:R-HSA-8848873 \"PTK6 phosphorylates ARAP1\"", "Reactome:R-HSA-8848975 \"PTK6 phosphorylates KHDRBS1\"", "Reactome:R-HSA-8849032 \"PTK6 phosphorylates KHDRBS2\"", "Reactome:R-HSA-8849042 \"PTK6 phosphorylates KHDRBS3\"", "Reactome:R-HSA-8849068 \"PTK6 phosphorylates ARHGAP35\"", "Reactome:R-HSA-8849102 \"SRMS phosphorylates PTK6\"", "Reactome:R-HSA-8849463 \"PTK6 phosphorylates SFPQ\"", "Reactome:R-HSA-8851890 \"MET phosphorylates SHC1-2\"", "Reactome:R-HSA-8851933 \"MET phosphorylates GAB1\"", "Reactome:R-HSA-8853309 \"Autocatalytic phosphorylation of FGFR3 fusions\"", "Reactome:R-HSA-8853313 \"FGFR2 fusions autophosphorylate\"", "Reactome:R-HSA-8853325 \"Plasma membrane FGFR1 fusions autophosphorylate\"", "Reactome:R-HSA-8855237 \"FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1\"", "Reactome:R-HSA-8857555 \"EGFR phosphorylates GPNMB\"", "Reactome:R-HSA-8857577 \"LINC01139 facilitates PTK6 autophosphorylation\"", "Reactome:R-HSA-8857583 \"LINC01139 promotes phosphorylation of HIF1A by PTK6\"", "Reactome:R-HSA-8857925 \"Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307\"", "Reactome:R-HSA-8867041 \"EGFR phosphorylates EPS15\"", "Reactome:R-HSA-8874078 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-8874080 \"SRC phosphorylates PTK2\"", "Reactome:R-HSA-8874082 \"MET phosphorylates PTK2\"", "Reactome:R-HSA-8875451 \"MET phosphorylates CBL\"", "Reactome:R-HSA-8875817 \"MET phosphorylates STAT3\"", "Reactome:R-HSA-8876230 \"InlB:MET dimer trans-autophophorylates\"", "Reactome:R-HSA-8876246 \"InlB-activated MET phosphorylates CBL\"", "Reactome:R-HSA-8876948 \"SRC phosphorylates InlA-bound CDH1 and CTNNB1\"", "Reactome:R-HSA-8937728 \"SRC phosphorylates RUNX1\"", "Reactome:R-HSA-8937807 \"SRC phosphorylates RUNX3\"", "Reactome:R-HSA-8937844 \"SRC,YES1 phosphorylate YAP1\"", "Reactome:R-HSA-8942607 \"Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes\"", "Reactome:R-HSA-8948143 \"p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18\"", "Reactome:R-HSA-8956659 \"ABL1 phosphorylates YAP1\"", "Reactome:R-HSA-8964242 \"G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8964252 \"G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8983872 \"JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4\"", "Reactome:R-HSA-9006323 \"Phospho-JAK2 phosphorylates EPOR\"", "Reactome:R-HSA-9006332 \"JAK2 transphosphorylates and is activated in response to Erythropoietin\"", "Reactome:R-HSA-9011241 \"SRC phosphorylates ROBO3.1 in response to NTN1\"", "Reactome:R-HSA-9012650 \"JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2\"", "Reactome:R-HSA-9018572 \"EGFR phosphorylates NOTCH3\"", "Reactome:R-HSA-9021609 \"ESR-associated SRC autophosphorylates\"", "Reactome:R-HSA-9024726 \"LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1\"", "Reactome:R-HSA-9026464 \"BDNF-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026502 \"NTF3-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026510 \"NTF4-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026579 \"NTRK2 phosphorylates PLCG1\"", "Reactome:R-HSA-9026890 \"NTRK2 phosphorylates SHC1\"", "Reactome:R-HSA-9027272 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2\"", "Reactome:R-HSA-9027273 \"JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1\"", "Reactome:R-HSA-9027425 \"LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2\"", "Reactome:R-HSA-9028728 \"NTRK2 phosphorylates FRS2\"", "Reactome:R-HSA-9029151 \"JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1\"", "Reactome:R-HSA-9029155 \"JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1\"", "Reactome:R-HSA-9032426 \"NTRK2 phosphorylates FRS3\"", "Reactome:R-HSA-9032532 \"NTRK2-bound FYN autophosphorylates\"", "Reactome:R-HSA-9032601 \"FYN-mediated phosphorylation of GRIN2B\"", "Reactome:R-HSA-9032854 \"NTRK2 phosphorylates CDK5\"", "Reactome:R-HSA-9033284 \"NTRK2 promotes TIAM1 phosphorylation\"", "Reactome:R-HSA-9034714 \"NTRK3 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9034814 \"NTRK3 phosphorylates PLCG1\"", "Reactome:R-HSA-9034875 \"NTRK3 phosphorylates SHC1\"", "Reactome:R-HSA-9037040 \"SRC,FYN phosphorylate NTRK2\"", "Reactome:R-HSA-909718 \"Formation of p-STAT1 homodimer\"", "Reactome:R-HSA-909726 \"Phosphorylation of STAT1\"", "Reactome:R-HSA-909729 \"Activation of JAK kinases\"", "Reactome:R-HSA-909730 \"Phosphorylation of INFAR1 by TYK2\"", "Reactome:R-HSA-909732 \"Phosphorylation of STAT2\"", "Reactome:R-HSA-912629 \"CBL is tyrosine phosphorylated\"", "Reactome:R-HSA-9603420 \"Activated NTRK3 promotes SRC autophosphorylation\"", "Reactome:R-HSA-9604767 \"FLT3LG dimer:FLT3 dimer autophosphorylates\"", "Reactome:R-HSA-9606159 \"BTK autophosphorylates\"", "Reactome:R-HSA-9606162 \"Phosphorylated BTK phosphorylates PLCG2\"", "Reactome:R-HSA-9606163 \"p-SYK and LYN phosphorylate BTK\"", "Reactome:R-HSA-9612085 \"SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs\"", "Reactome:R-HSA-9612996 \"NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9613023 \"NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9624014 \"SHC1 is phosphorylated downstream of estrogen stimulation of GPER1\"", "Reactome:R-HSA-9625487 \"PTK2 autophosphorylates downstream of EGFR\"", "Reactome:R-HSA-9634390 \"ERBB2 homodimer phosphorylates SHC1\"", "Reactome:R-HSA-9664261 \"Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK\"", "Reactome:R-HSA-9664275 \"Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers\"", "Reactome:R-HSA-9664278 \"Phosphorylation and activation of PLCG due to FCGR3A effect\"", "Reactome:R-HSA-9664588 \"ERBB2 KD mutants trans-autophosphorylate\"", "Reactome:R-HSA-9664976 \"Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665032 \"Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665389 \"Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate\"", "Reactome:R-HSA-9665411 \"Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665704 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665705 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665709 \"ERBB2 TMD/JMD heterodimers trans-autophosphorylate\"", "Reactome:R-HSA-9666425 \"p-6Y-SYK phosphorylates VAV1,2,3\"", "Reactome:R-HSA-9669890 \"Constitutive phosphorylation of kinase domain KIT mutants\"", "Reactome:R-HSA-9669911 \"Phosphorylation of juxtamembrane domain KIT mutants\"", "Reactome:R-HSA-9670412 \"Phosphorylation of STATs downstream of KIT mutants\"", "Reactome:R-HSA-9670418 \"Phosphorylation of JAK2 downstream of KIT mutants\"", "Reactome:R-HSA-9672173 \"Autophosphorylation of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672175 \"Autophosphorylation of PDGFR mutant dimers\"", "Reactome:R-HSA-9673756 \"Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins\"", "Reactome:R-HSA-9673761 \"Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB\"", "Reactome:R-HSA-9674558 \"p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1\"", "Reactome:R-HSA-9674567 \"p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2\"", "Reactome:R-HSA-9680248 \"Phosphorylation of extracellular domain KIT mutants\"", "Reactome:R-HSA-9695834 \"Constitutive phosphorylation of FLT3 mutants\"", "Reactome:R-HSA-9698003 \"FLT3 mutants phosphorylate GAB2\"", "Reactome:R-HSA-9698005 \"FLT3 ITD mutants phosphorylate STAT5\"", "Reactome:R-HSA-9699578 \"Active FLT3 phosphorylates CDKN1B\"", "Reactome:R-HSA-9700164 \"Active ALK phosphorylates FRS2\"", "Reactome:R-HSA-9700168 \"Active ALK phosphorylates IRS1\"", "Reactome:R-HSA-9700171 \"Active ALK phosphorylates PLCG1\"", "Reactome:R-HSA-9700175 \"Active ALK phosphorylates SHC1\"", "Reactome:R-HSA-9700181 \"Autophosphorylation of ALK fusions\"", "Reactome:R-HSA-9700186 \"Autophosphorylation of point mutants of ALK\"", "Reactome:R-HSA-9700193 \"ALK mutants phosphorylate SHC1\"", "Reactome:R-HSA-9700647 \"Active ALK phosphorylates SRC\"", "Reactome:R-HSA-9701488 \"Active ALK phosphorylates JAK3\"", "Reactome:R-HSA-9703437 \"FLT3 fusion dimers autophosphorylate\"", "Reactome:R-HSA-9703438 \"FLT3 fusions phosphorylate GAB2\"", "Reactome:R-HSA-9706344 \"FLT3 phosphorylates GRB10\"", "Reactome:R-HSA-9706350 \"FLT3 phosphorylates CBL\"", "Reactome:R-HSA-9709918 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-9712082 \"ALK fusions phosphorylate IRS1\"", "Reactome:R-HSA-9712085 \"ALK mutants phosphorylate STAT3\"", "Reactome:R-HSA-9712086 \"ALK fusions phosphorylate PLCG1\"", "Reactome:R-HSA-9712087 \"ALK fusions phosphorylate FRS\"", "Reactome:R-HSA-9726848 \"SRC phosphorylates RHOU\"", "Reactome:R-HSA-9732738 \"JAK1-mediated phosphorylation of RAF1\"", "Reactome:R-HSA-9733314 \"CSF1R trans-autophosphorylates on tyrosine-561\"", "Reactome:R-HSA-9733323 \"Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL\"", "Reactome:R-HSA-9762209 \"BACH1 is phosphorylated at tyrosine 483\"", "Reactome:R-HSA-982807 \"JAK2 phosphorylation of GHR\"", "Reactome:R-HSA-9831136 \"SH pentamer is phosphorylated\"", "Reactome:R-HSA-983703 \"p-6Y-SYK phosphorylates BLNK (SLP65)\"", "Reactome:R-HSA-983707 \"SYK autophosphorylates at the activated BCR\"", "Reactome:R-HSA-983709 \"LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)\"", "RHEA:10596" ], "previous": [ "Reactome:R-HSA-112333 \"SRC autophosphorylation is positively regulated by InlA-bound CDH1\"", "Reactome:R-HSA-114600 \"Fyn/Lyn-mediated phosphorylation of FcR1 gamma\"", "Reactome:R-HSA-1168394 \"STAT5 tyrosine phosphorylation\"", "Reactome:R-HSA-1169421 \"Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers\"", "Reactome:R-HSA-1225952 \"Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1225960 \"Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1247844 \"Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1248655 \"Trans-autophosphorylation of EGFRvIII mutant dimers\"", "Reactome:R-HSA-1248694 \"Trans-autophosphorylation of ERBB2 homodimer\"", "Reactome:R-HSA-1250195 \"SHC1 phosphorylation by ERBB2 heterodimers\"", "Reactome:R-HSA-1250315 \"Trans-autophosphorylation of ERBB4 homodimers\"", "Reactome:R-HSA-1250348 \"Phosphorylation of SHC1 by ERBB4 homodimers\"", "Reactome:R-HSA-1251922 \"PLCG1 phosphorylation by p-EGFR:p-ERBB2\"", "Reactome:R-HSA-1295540 \"IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5\"", "Reactome:R-HSA-1295609 \"SRC phosphorylates SPRY2 on Y55 and Y227\"", "Reactome:R-HSA-1307963 \"Autocatalytic phosphorylation of BetaKlotho-bound FGFR4\"", "Reactome:R-HSA-1433418 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-1433454 \"Phosphorylation of GAB2 by SFKs\"", "Reactome:R-HSA-1433488 \"Phosphorylation of SHP2 by SFKs\"", "Reactome:R-HSA-1433506 \"Phosphorylation of APS\"", "Reactome:R-HSA-1433542 \"Phosphorylation and activation of VAV1\"", "Reactome:R-HSA-1470009 \"Phosphorylation of STATs\"", "Reactome:R-HSA-1472121 \"Phosphorylation of p-KIT on Y900 by Src kinases\"", "Reactome:R-HSA-1524186 \"Phosphorylation of PLCgamma by PDGFR\"", "Reactome:R-HSA-1671691 \"PRLR-bound STAT5 is phosphorylated\"", "Reactome:R-HSA-170070 \"Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170156 \"Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170991 \"SRC-1 autophosphorylates\"", "Reactome:R-HSA-171011 \"Binding and activation of MAP Kinase\"", "Reactome:R-HSA-174164 \"Phosphorylation of Cyclin A:Cdk2 at Tyr 15\"", "Reactome:R-HSA-177930 \"GAB1 phosphorylation by EGFR kinase\"", "Reactome:R-HSA-177934 \"EGFR autophosphorylation\"", "Reactome:R-HSA-177937 \"Phosphorylation of EGFR by SRC kinase\"", "Reactome:R-HSA-182969 \"Phosphorylation of CBL (EGFR:CBL)\"", "Reactome:R-HSA-183058 \"Phosphorylation of CBL (EGFR:GRB2:CBL)\"", "Reactome:R-HSA-1839065 \"Phosphorylation of cytosolic FGFR1 fusion dimers\"", "Reactome:R-HSA-1839067 \"Phosphorylation of BCR moiety of BCR-FGFR1\"", "Reactome:R-HSA-1839098 \"Activated FGFR1 mutants and fusions phosphorylate PLCG1\"", "Reactome:R-HSA-1839110 \"p-BCR-p-FGFR1 phosphorylates GAB2\"", "Reactome:R-HSA-1839112 \"Phosphorylation of STAT5 by cytosolic FGFR1 fusions\"", "Reactome:R-HSA-186786 \"Autophosphorylation of PDGF beta receptors\"", "Reactome:R-HSA-1888198 \"FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3\"", "Reactome:R-HSA-190326 \"Autocatalytic phosphorylation of FGFR4\"", "Reactome:R-HSA-190385 \"Autocatalytic phosphorylation of FGFR3b\"", "Reactome:R-HSA-190388 \"Autocatalytic phosphorylation of FGFR3c\"", "Reactome:R-HSA-190408 \"Autocatalytic phosphorylation of FGFR2b\"", "Reactome:R-HSA-190413 \"Autocatalytic phosphorylation of FGFR2c\"", "Reactome:R-HSA-190427 \"Autocatalytic phosphorylation of FGFR1b\"", "Reactome:R-HSA-190429 \"Autocatalytic phosphorylation of FGFR1c\"", "Reactome:R-HSA-191062 \"Autocatalytic phosphorylation of Klotho-bound FGFR1c\"", "Reactome:R-HSA-191636 \"Phosphorylation of Cx43 by c-src\"", "Reactome:R-HSA-1963581 \"Trans-autophosphorylation of p-Y877-ERBB2 heterodimers\"", "Reactome:R-HSA-1963582 \"Trans-autophosphorylation of ERBB2 heterodimers\"", "Reactome:R-HSA-1963586 \"SRC family kinases phosphorylate ERBB2\"", "Reactome:R-HSA-1982066 \"Ligand-independent phosphorylation of overexpressed FGFR1\"", "Reactome:R-HSA-2012073 \"Autocatalytic phosphorylation of FGFR3c P250R mutant\"", "Reactome:R-HSA-2012082 \"Autocatalytic phosphorylation of FGFR3 cysteine mutants\"", "Reactome:R-HSA-2012087 \"Autocatalytic phosphorylation of FGFR4 Y367C mutant\"", "Reactome:R-HSA-201521 \"ALK autophosphorylation downstream of PTN and MDK\"", "Reactome:R-HSA-202165 \"Phosphorylation of ITAM motifs in CD3 complexes\"", "Reactome:R-HSA-202168 \"Phosphorylation of ZAP-70 by Lck\"", "Reactome:R-HSA-202174 \"Activation of ZAP-70\"", "Reactome:R-HSA-202216 \"Phosphorylation of SLP-76\"", "Reactome:R-HSA-202233 \"Inactivation of Lck by Csk\"", "Reactome:R-HSA-202245 \"Phosphorylation of TBSMs in LAT\"", "Reactome:R-HSA-202248 \"Phosphorylation of PLC-gamma1\"", "Reactome:R-HSA-202291 \"Activation of Lck\"", "Reactome:R-HSA-202307 \"Change of PKC theta conformation\"", "Reactome:R-HSA-2023455 \"Autocatalytic phosphorylation of FGFR1c P252X mutant dimers\"", "Reactome:R-HSA-2023460 \"Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity\"", "Reactome:R-HSA-2029268 \"Phosphorylation and activation of PLCG\"", "Reactome:R-HSA-2029449 \"Phosphorylation of SYK by Src kinases\"", "Reactome:R-HSA-2029453 \"Phosphorylation of VAV\"", "Reactome:R-HSA-2029459 \"Sequestering and phosphorylation Fc gamma receptors in the lipid rafts\"", "Reactome:R-HSA-2029984 \"Autocatalytic phosphorylation of FGFR2 ligand-independent mutants\"", "Reactome:R-HSA-2029989 \"Autocatalytic phosphorylation of overexpressed FGFR2 variants\"", "Reactome:R-HSA-2033485 \"Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2033486 \"Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033488 \"Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033490 \"Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2038387 \"Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants\"", "Reactome:R-HSA-2038944 \"Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity\"", "Reactome:R-HSA-205289 \"Autophosphorylation of KIT\"", "Reactome:R-HSA-210291 \"Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src\"", "Reactome:R-HSA-210872 \"Trans-phosphorylation of Tie2\"", "Reactome:R-HSA-212710 \"EGFR activates PLC-gamma1 by phosphorylation\"", "Reactome:R-HSA-2130194 \"ABL phosphorylates WAVEs\"", "Reactome:R-HSA-2197698 \"Src phosphorylate WASP,N-WASP\"", "Reactome:R-HSA-2201322 \"TIRAP is phosphorylated by BTK\"", "Reactome:R-HSA-2395412 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2395439 \"Phosphorylation of DAP12\"", "Reactome:R-HSA-2395801 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2396594 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2404193 \"IGF1R phosphorylates SHC1\"", "Reactome:R-HSA-2404199 \"IGF1,2:IGF1R autophosphorylates\"", "Reactome:R-HSA-2424484 \"Phosphorylation of BTK by p-SYK\"", "Reactome:R-HSA-2424486 \"Phosphorylation and activation of VAV2/VAV3 by SYK\"", "Reactome:R-HSA-2424487 \"Phosphorylation of PLC-gamma by p-BTK/p-SYK\"", "Reactome:R-HSA-2428926 \"IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4\"", "Reactome:R-HSA-2454208 \"Phosphorylation of beta and gamma subunits by LYN\"", "Reactome:R-HSA-2454239 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2586553 \"JAK2 Phosphorylates LEPR\"", "Reactome:R-HSA-2586555 \"JAK2 Autophosphorylates in Response to Leptin\"", "Reactome:R-HSA-2671742 \"JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin\"", "Reactome:R-HSA-2671829 \"JAK2 Phosphorylates STAT5 in Response to Leptin\"", "Reactome:R-HSA-2671850 \"JAK2 Phosphoryates STAT3 in Response to Leptin\"", "Reactome:R-HSA-2730833 \"Phosphorylation of TEC kinases by p-SYK\"", "Reactome:R-HSA-2730843 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2730851 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2730858 \"Autophosphorylation of BTK/ITK\"", "Reactome:R-HSA-2730860 \"Phosphorylation of GAB2 by SYK/FYN\"", "Reactome:R-HSA-2730862 \"Autophosphorylation of LYN kinase\"", "Reactome:R-HSA-2730882 \"Phosphorylation of PKC-theta\"", "Reactome:R-HSA-2730884 \"Phosphorylation of NTAL by p-SYK/Lyn\"", "Reactome:R-HSA-2730886 \"Phosphorylation of SHC by SYK kinase\"", "Reactome:R-HSA-2730888 \"Phosphorylation of PLC-gamma\"", "Reactome:R-HSA-3215391 \"PRMT5 is tyrosine phosphorylated by JAK2 V617F\"", "Reactome:R-HSA-354073 \"Autophosphorylation of PTK2 at Y397\"", "Reactome:R-HSA-354124 \"Phosphorylation of pPTK2 by SRC\"", "Reactome:R-HSA-372693 \"Phosphorylation of BCAR1 by SRC-PTK2 complex\"", "Reactome:R-HSA-373747 \"Phosphorylation of nephrin by FYN\"", "Reactome:R-HSA-373750 \"SEMA4D interacts with Plexin-B1:ErbB2\"", "Reactome:R-HSA-374701 \"Phosphorylation of DCC by Fyn\"", "Reactome:R-HSA-377640 \"Autophosphorylation of SRC\"", "Reactome:R-HSA-380780 \"Activation of Src\"", "Reactome:R-HSA-388831 \"Phosphorylation of CD28\"", "Reactome:R-HSA-388833 \"Phosphorylation of CTLA-4\"", "Reactome:R-HSA-389083 \"Autophosphorylation of PDGF alpha receptors\"", "Reactome:R-HSA-389086 \"Autophosphorylation of PDGF alpha/beta receptors\"", "Reactome:R-HSA-389159 \"CSF1R trans-autophosphorylates on multiple tyrosine and serine residues\"", "Reactome:R-HSA-389354 \"Activation of Vav1\"", "Reactome:R-HSA-389762 \"Phosphorylation of PD-1\"", "Reactome:R-HSA-391156 \"Phosphorylation of ITIM motif in SIRP alpha\"", "Reactome:R-HSA-391865 \"Recruitment of FAK to NCAM1:Fyn in lipid rafts\"", "Reactome:R-HSA-391866 \"Phosphorylation of FAK by Src kinase\"", "Reactome:R-HSA-391871 \"Autophosphorylation of NCAM1 bound Fyn\"", "Reactome:R-HSA-3928578 \"EPH receptors autophosphorylate\"", "Reactome:R-HSA-3928580 \"SFKs phosphorylate EFNBs\"", "Reactome:R-HSA-3928583 \"FYN phosphorylates NMDAR2B\"", "Reactome:R-HSA-3928594 \"SFKs phosphorylate GIT1\"", "Reactome:R-HSA-3928604 \"SFKs phosphorylate VAV2,3\"", "Reactome:R-HSA-3928610 \"PTK2 autophosphorylates at Y397\"", "Reactome:R-HSA-3928627 \"EPHB phosphorylates TIAM1\"", "Reactome:R-HSA-3928648 \"SFKs phosphorylate NGEF\"", "Reactome:R-HSA-399934 \"Phosphorylation of Plexin-A\"", "Reactome:R-HSA-399946 \"Recruitment and activation of Cdk5\"", "Reactome:R-HSA-399947 \"Tyrosine phosphorylation of CRMPs by Fes\"", "Reactome:R-HSA-4093332 \"p-EPHB phosphorylates SDC2\"", "Reactome:R-HSA-418163 \"Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)\"", "Reactome:R-HSA-418859 \"Phosphorylation of Unc5C\"", "Reactome:R-HSA-418872 \"Phosphorylation of FADK1\"", "Reactome:R-HSA-419646 \"SEMA4D interacts with Plexin-B1:Met\"", "Reactome:R-HSA-428888 \"Phosphorylation of ROBO1 by ABL kinase\"", "Reactome:R-HSA-429441 \"SYK activation by SRC\"", "Reactome:R-HSA-429449 \"Syk activation leads to SLP-76 activation\"", "Reactome:R-HSA-432129 \"FGR binds and phosphorylates LRP8\"", "Reactome:R-HSA-434836 \"Syk/Lck phosphorylate LAT\"", "Reactome:R-HSA-4420117 \"VEGFR2 autophosphorylates\"", "Reactome:R-HSA-4420121 \"SFKs phosphorylate PLCG1\"", "Reactome:R-HSA-4420128 \"SRC-1 phosphorylates SHB\"", "Reactome:R-HSA-4420206 \"Phosphorylation of SRC-1\"", "Reactome:R-HSA-443817 \"Phosphorylation of L1 by EPHB2\"", "Reactome:R-HSA-445076 \"Phosphorylation of Y1229 in L1\"", "Reactome:R-HSA-445084 \"Phosphorylation of L1 by SRC\"", "Reactome:R-HSA-445085 \"Phosphorylation of VAV2\"", "Reactome:R-HSA-445091 \"Phosphorylation of Neurofascin\"", "Reactome:R-HSA-451942 \"Within the IL-2R complex JAK3 phosphorylates JAK1\"", "Reactome:R-HSA-452097 \"Recruited STAT5 is phosphorylated\"", "Reactome:R-HSA-452100 \"SHC1 bound to IL2 receptor is phosphorylated\"", "Reactome:R-HSA-452122 \"JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB\"", "Reactome:R-HSA-508282 \"SYK is a substrate for JAK1\"", "Reactome:R-HSA-5218640 \"SRC-1 phosphorylates p-Y397-PTK2\"", "Reactome:R-HSA-5218642 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-5218806 \"FYN autophosphorylates\"", "Reactome:R-HSA-5218809 \"PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118\"", "Reactome:R-HSA-5218812 \"FYN phosphorylates PAK2\"", "Reactome:R-HSA-5218820 \"Src kinases phosphorylate VAV\"", "Reactome:R-HSA-5218828 \"PTK2/SRC-1 phosphorylates BCAR1\"", "Reactome:R-HSA-5218830 \"SRC-1 phosphorylates PTK2-beta\"", "Reactome:R-HSA-5218851 \"p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407\"", "Reactome:R-HSA-5357429 \"AXL autophosphorylates on Y772 and Y814\"", "Reactome:R-HSA-5607745 \"1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG\"", "Reactome:R-HSA-5607750 \"SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan\"", "Reactome:R-HSA-5621355 \"LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG\"", "Reactome:R-HSA-5621363 \"SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2\"", "Reactome:R-HSA-5621370 \"SYK autophosphorylates\"", "Reactome:R-HSA-5624486 \"SFKs phosphorylates RAF1 on Y340,Y341\"", "Reactome:R-HSA-5637795 \"Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant\"", "Reactome:R-HSA-5637796 \"Phosphorylation of SHC1 by p-5Y-EGFRvIII\"", "Reactome:R-HSA-5654147 \"Activated FGFR2 phosphorylates PLCG1\"", "Reactome:R-HSA-5654149 \"Activated FGFR1 phosphorylates PLCG1\"", "Reactome:R-HSA-5654151 \"Activated FGFR4 phosphorylates PLCG1\"", "Reactome:R-HSA-5654222 \"Activated FGFR3 phosphorylates PLCG1\"", "Reactome:R-HSA-5654397 \"Activated FGFR2 phosphorylates FRS2\"", "Reactome:R-HSA-5654407 \"Activated FGFR2 phosphorylates SHC1\"", "Reactome:R-HSA-5654408 \"Activated FGFR3 phosphorylates FRS2\"", "Reactome:R-HSA-5654418 \"Activated FGFR4 phosphorylates FRS2\"", "Reactome:R-HSA-5654428 \"Activated FGFR4 phosphorylates SHC1\"", "Reactome:R-HSA-5654545 \"Ligand-independent phosphorylation of overexpressed FGFR1c\"", "Reactome:R-HSA-5654575 \"Activated FGFR1 phosphorylates FRS2\"", "Reactome:R-HSA-5654578 \"Activated FGFR1 phosphorylates FRS3\"", "Reactome:R-HSA-5654582 \"Activated FGFR1 phosphorylates SHC1\"", "Reactome:R-HSA-5654587 \"Activated FGFR1:p-FRS phosphorylates PPTN11\"", "Reactome:R-HSA-5654605 \"Activated FGFR2 phosphorylates FRS3\"", "Reactome:R-HSA-5654607 \"Activated FGFR2 phosphorylates PPTN11\"", "Reactome:R-HSA-5654628 \"Activated FGFR3 phosphorylates FRS3\"", "Reactome:R-HSA-5654631 \"Activated FGFR3 phosphorylates PPTN11\"", "Reactome:R-HSA-5654634 \"Activated FGFR3 phosphorylates SHC1\"", "Reactome:R-HSA-5654653 \"Activated FGFR4 phosphorylates FRS3\"", "Reactome:R-HSA-5654655 \"Activated FGFR4 phosphorylates PPTN11\"", "Reactome:R-HSA-5655243 \"Activated FGFR3 point and translocation mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655268 \"Activated FGFR2 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655270 \"Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655278 \"Activated FGFR1 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655284 \"Activated FGFR4 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655301 \"Activated FGFR2 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655341 \"Activated FGFR4 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5683930 \"WICH phosphorylates H2AFX on Y142\"", "Reactome:R-HSA-5686587 \"ABL1 phosphorylates RAD52\"", "Reactome:R-HSA-5690702 \"LYN phosphorylates CD22\"", "Reactome:R-HSA-6784006 \"STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2\"", "Reactome:R-HSA-6784319 \"JAK1,TYK2 phosphorylate JAK1,TYK2\"", "Reactome:R-HSA-6790087 \"HVEM induses BTLA phosphorylation\"", "Reactome:R-HSA-6806974 \"MET dimers autophosphorylate\"", "Reactome:R-HSA-68954 \"Mcm2-7 is phosphorylated by DDK\"", "Reactome:R-HSA-69195 \"Phosphorylation of Cyclin E:CDK2 complexes by WEE1\"", "Reactome:R-HSA-873918 \"Transphosphorylation of JAK1\"", "Reactome:R-HSA-873919 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-873922 \"Phosphorylation of STAT1 by JAK kinases\"", "Reactome:R-HSA-873924 \"Phosphorylation of IFNGR1 by JAK kinases\"", "Reactome:R-HSA-879907 \"Tyrosine kinases phosphorylate the receptor\"", "Reactome:R-HSA-879909 \"Activation of STAT5a/b by JAK2\"", "Reactome:R-HSA-879925 \"SHC1 bound to the common beta chain becomes tyrosine phosphorylated\"", "Reactome:R-HSA-8847977 \"FRK phosphorylates PTEN\"", "Reactome:R-HSA-8848005 \"ERBB2 promotes PTK6 autophosphorylation\"", "Reactome:R-HSA-8848077 \"PTK6 phosphorylates STAP2\"", "Reactome:R-HSA-8848124 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-8848436 \"PTK6 phosphorylates CDKN1B\"", "Reactome:R-HSA-8848606 \"PTK6 phosphorylates PXN\"", "Reactome:R-HSA-8848726 \"PTK6 phosphorylates BCAR1\"", "Reactome:R-HSA-8848758 \"PTK6 phosphorylates AKT1\"", "Reactome:R-HSA-8848776 \"PTK6 phosphorylates DOK1\"", "Reactome:R-HSA-8848818 \"PTK6 phosphorylates CBL\"", "Reactome:R-HSA-8848873 \"PTK6 phosphorylates ARAP1\"", "Reactome:R-HSA-8848975 \"PTK6 phosphorylates KHDRBS1\"", "Reactome:R-HSA-8849032 \"PTK6 phosphorylates KHDRBS2\"", "Reactome:R-HSA-8849042 \"PTK6 phosphorylates KHDRBS3\"", "Reactome:R-HSA-8849068 \"PTK6 phosphorylates ARHGAP35\"", "Reactome:R-HSA-8849102 \"SRMS phosphorylates PTK6\"", "Reactome:R-HSA-8849463 \"PTK6 phosphorylates SFPQ\"", "Reactome:R-HSA-8851890 \"MET phosphorylates SHC1-2\"", "Reactome:R-HSA-8851933 \"MET phosphorylates GAB1\"", "Reactome:R-HSA-8853309 \"Autocatalytic phosphorylation of FGFR3 fusions\"", "Reactome:R-HSA-8853313 \"FGFR2 fusions autophosphorylate\"", "Reactome:R-HSA-8853325 \"Plasma membrane FGFR1 fusions autophosphorylate\"", "Reactome:R-HSA-8855237 \"FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1\"", "Reactome:R-HSA-8857555 \"EGFR phosphorylates GPNMB\"", "Reactome:R-HSA-8857577 \"LINC01139 facilitates PTK6 autophosphorylation\"", "Reactome:R-HSA-8857583 \"LINC01139 promotes phosphorylation of HIF1A by PTK6\"", "Reactome:R-HSA-8857925 \"Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307\"", "Reactome:R-HSA-8867041 \"EGFR phosphorylates EPS15\"", "Reactome:R-HSA-8874078 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-8874080 \"SRC phosphorylates PTK2\"", "Reactome:R-HSA-8874082 \"MET phosphorylates PTK2\"", "Reactome:R-HSA-8875451 \"MET phosphorylates CBL\"", "Reactome:R-HSA-8875817 \"MET phosphorylates STAT3\"", "Reactome:R-HSA-8876230 \"InlB:MET dimer trans-autophophorylates\"", "Reactome:R-HSA-8876246 \"InlB-activated MET phosphorylates CBL\"", "Reactome:R-HSA-8876948 \"SRC phosphorylates InlA-bound CDH1 and CTNNB1\"", "Reactome:R-HSA-8937728 \"SRC phosphorylates RUNX1\"", "Reactome:R-HSA-8937807 \"SRC phosphorylates RUNX3\"", "Reactome:R-HSA-8937844 \"SRC,YES1 phosphorylate YAP1\"", "Reactome:R-HSA-8942607 \"Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes\"", "Reactome:R-HSA-8948143 \"p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18\"", "Reactome:R-HSA-8956659 \"ABL1 phosphorylates YAP1\"", "Reactome:R-HSA-8964242 \"G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC\"", "Reactome:R-HSA-8964252 \"G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC\"", "Reactome:R-HSA-8983872 \"JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4\"", "Reactome:R-HSA-9006323 \"Phospho-JAK2 phosphorylates EPOR\"", "Reactome:R-HSA-9006332 \"JAK2 transphosphorylates and is activated in response to Erythropoietin\"", "Reactome:R-HSA-9011241 \"SRC phosphorylates ROBO3.1 in response to NTN1\"", "Reactome:R-HSA-9012650 \"JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2\"", "Reactome:R-HSA-9018572 \"EGFR phosphorylates NOTCH3\"", "Reactome:R-HSA-9021609 \"ESR-associated SRC autophosphorylates\"", "Reactome:R-HSA-9024726 \"LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1\"", "Reactome:R-HSA-9026464 \"BDNF-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026502 \"NTF3-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026510 \"NTF4-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026579 \"NTRK2 phosphorylates PLCG1\"", "Reactome:R-HSA-9026890 \"NTRK2 phosphorylates SHC1\"", "Reactome:R-HSA-9027272 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2\"", "Reactome:R-HSA-9027273 \"JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1\"", "Reactome:R-HSA-9027425 \"LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2\"", "Reactome:R-HSA-9028728 \"NTRK2 phosphorylates FRS2\"", "Reactome:R-HSA-9029151 \"JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1\"", "Reactome:R-HSA-9029155 \"JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1\"", "Reactome:R-HSA-9032426 \"NTRK2 phosphorylates FRS3\"", "Reactome:R-HSA-9032532 \"NTRK2-bound FYN autophosphorylates\"", "Reactome:R-HSA-9032601 \"FYN-mediated phosphorylation of GRIN2B\"", "Reactome:R-HSA-9032854 \"NTRK2 phosphorylates CDK5\"", "Reactome:R-HSA-9033284 \"NTRK2 promotes TIAM1 phosphorylation\"", "Reactome:R-HSA-9034714 \"NTRK3 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9034814 \"NTRK3 phosphorylates PLCG1\"", "Reactome:R-HSA-9034875 \"NTRK3 phosphorylates SHC1\"", "Reactome:R-HSA-9037040 \"SRC,FYN phosphorylate NTRK2\"", "Reactome:R-HSA-909718 \"Formation of p-STAT1 homodimer\"", "Reactome:R-HSA-909726 \"Phosphorylation of STAT1\"", "Reactome:R-HSA-909729 \"Activation of JAK kinases\"", "Reactome:R-HSA-909730 \"Phosphorylation of INFAR1 by TYK2\"", "Reactome:R-HSA-909732 \"Phosphorylation of STAT2\"", "Reactome:R-HSA-912629 \"CBL is tyrosine phosphorylated\"", "Reactome:R-HSA-9603420 \"Activated NTRK3 promotes SRC autophosphorylation\"", "Reactome:R-HSA-9604767 \"FLT3LG dimer:FLT3 dimer autophosphorylates\"", "Reactome:R-HSA-9606159 \"BTK autophosphorylates\"", "Reactome:R-HSA-9606162 \"Phosphorylated BTK phosphorylates PLCG2\"", "Reactome:R-HSA-9606163 \"p-SYK and LYN phosphorylate BTK\"", "Reactome:R-HSA-9612085 \"SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs\"", "Reactome:R-HSA-9612996 \"NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9613023 \"NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9624014 \"SHC1 is phosphorylated downstream of estrogen stimulation of GPER1\"", "Reactome:R-HSA-9625487 \"PTK2 autophosphorylates downstream of EGFR\"", "Reactome:R-HSA-9634390 \"ERBB2 homodimer phosphorylates SHC1\"", "Reactome:R-HSA-9664261 \"Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK\"", "Reactome:R-HSA-9664275 \"Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers\"", "Reactome:R-HSA-9664278 \"Phosphorylation and activation of PLCG due to FCGR3A effect\"", "Reactome:R-HSA-9664588 \"ERBB2 KD mutants trans-autophosphorylate\"", "Reactome:R-HSA-9664976 \"Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665032 \"Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665389 \"Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate\"", "Reactome:R-HSA-9665411 \"Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665704 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665705 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665709 \"ERBB2 TMD/JMD heterodimers trans-autophosphorylate\"", "Reactome:R-HSA-9666425 \"p-6Y-SYK phosphorylates VAV1,2,3\"", "Reactome:R-HSA-9669890 \"Constitutive phosphorylation of kinase domain KIT mutants\"", "Reactome:R-HSA-9669911 \"Phosphorylation of juxtamembrane domain KIT mutants\"", "Reactome:R-HSA-9670412 \"Phosphorylation of STATs downstream of KIT mutants\"", "Reactome:R-HSA-9670418 \"Phosphorylation of JAK2 downstream of KIT mutants\"", "Reactome:R-HSA-9672173 \"Autophosphorylation of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672175 \"Autophosphorylation of PDGFR mutant dimers\"", "Reactome:R-HSA-9673756 \"Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins\"", "Reactome:R-HSA-9673761 \"Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB\"", "Reactome:R-HSA-9674558 \"p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1\"", "Reactome:R-HSA-9674567 \"p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2\"", "Reactome:R-HSA-9680248 \"Phosphorylation of extracellular domain KIT mutants\"", "Reactome:R-HSA-9695834 \"Constitutive phosphorylation of FLT3 mutants\"", "Reactome:R-HSA-9698003 \"FLT3 mutants phosphorylate GAB2\"", "Reactome:R-HSA-9698005 \"FLT3 ITD mutants phosphorylate STAT5\"", "Reactome:R-HSA-9699578 \"Active FLT3 phosphorylates CDKN1B\"", "Reactome:R-HSA-9700164 \"Active ALK phosphorylates FRS2\"", "Reactome:R-HSA-9700168 \"Active ALK phosphorylates IRS1\"", "Reactome:R-HSA-9700171 \"Active ALK phosphorylates PLCG1\"", "Reactome:R-HSA-9700175 \"Active ALK phosphorylates SHC1\"", "Reactome:R-HSA-9700181 \"Autophosphorylation of ALK fusions\"", "Reactome:R-HSA-9700186 \"Autophosphorylation of point mutants of ALK\"", "Reactome:R-HSA-9700193 \"ALK mutants phosphorylate SHC1\"", "Reactome:R-HSA-9700647 \"Active ALK phosphorylates SRC\"", "Reactome:R-HSA-9701488 \"Active ALK phosphorylates JAK3\"", "Reactome:R-HSA-9703437 \"FLT3 fusion dimers autophosphorylate\"", "Reactome:R-HSA-9703438 \"FLT3 fusions phosphorylate GAB2\"", "Reactome:R-HSA-9706344 \"FLT3 phosphorylates GRB10\"", "Reactome:R-HSA-9706350 \"FLT3 phosphorylates CBL\"", "Reactome:R-HSA-9709918 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-9712082 \"ALK fusions phosphorylate IRS1\"", "Reactome:R-HSA-9712085 \"ALK mutants phosphorylate STAT3\"", "Reactome:R-HSA-9712086 \"ALK fusions phosphorylate PLCG1\"", "Reactome:R-HSA-9712087 \"ALK fusions phosphorylate FRS\"", "Reactome:R-HSA-9726848 \"SRC phosphorylates RHOU\"", "Reactome:R-HSA-9733314 \"CSF1R trans-autophosphorylates on tyrosine-561\"", "Reactome:R-HSA-9733323 \"Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL\"", "Reactome:R-HSA-9762209 \"BACH1 is phosphorylated at tyrosine 486\"", "Reactome:R-HSA-982807 \"JAK2 phosphorylation of GHR\"", "Reactome:R-HSA-983703 \"p-6Y-SYK phosphorylates BLNK (SLP65)\"", "Reactome:R-HSA-983707 \"SYK autophosphorylates at the activated BCR\"", "Reactome:R-HSA-983709 \"LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)\"", "RHEA:10596" ] } } }, { "id": "GO:0004714", "name": "transmembrane receptor protein tyrosine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.10.1", "MetaCyc:2.7.10.1-RXN", "Reactome:R-HSA-166544 \"TrkA receptor autophosphorylates\"", "Reactome:R-HSA-167019 \"SHC, complexed with TrkA, is tyrosine-phosphorylated\"", "Reactome:R-HSA-167683 \"TrkA phosphorylates PLCG1\"", "Reactome:R-HSA-169905 \"ARMS is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-177930 \"GAB1 phosphorylation by EGFR kinase\"", "Reactome:R-HSA-177933 \"SHC1 phosphorylation by phosphorylated EGFR\"", "Reactome:R-HSA-198295 \"TRKA phosphorylates IRS\"", "Reactome:R-HSA-6784324 \"p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA\"", "Reactome:R-HSA-74711 \"Phosphorylation of IRS\"", "Reactome:R-HSA-74742 \"Phosphorylation of SHC1\"", "Reactome:R-HSA-8852552 \"MST1R autophosphorylates\"", "Reactome:R-HSA-8853792 \"RET tyrosine phosphorylation\"", "Reactome:R-HSA-8950269 \"STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor\"", "Reactome:R-HSA-8950340 \"IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation\"", "Reactome:R-HSA-8950354 \"STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction\"", "Reactome:R-HSA-8950364 \"IL23R in IL23:IL23 receptor complex is phosphorylated\"", "Reactome:R-HSA-8950405 \"JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated\"", "Reactome:R-HSA-8950423 \"JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated\"", "Reactome:R-HSA-8950453 \"JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4\"", "Reactome:R-HSA-8950485 \"STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction\"", "Reactome:R-HSA-8950537 \"JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated\"", "Reactome:R-HSA-8950591 \"JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated\"", "Reactome:R-HSA-8950757 \"IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated\"", "Reactome:R-HSA-8982163 \"IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8983300 \"IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1\"", "Reactome:R-HSA-8983309 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1\"", "Reactome:R-HSA-8983371 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5\"", "Reactome:R-HSA-8983424 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2\"", "Reactome:R-HSA-8986985 \"IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5\"", "Reactome:R-HSA-8986994 \"IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2\"", "Reactome:R-HSA-8986995 \"IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA\"", "Reactome:R-HSA-8987012 \"IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1\"", "Reactome:R-HSA-8987040 \"IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1\"", "Reactome:R-HSA-8987042 \"IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2\"", "Reactome:R-HSA-8987070 \"IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987084 \"IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1\"", "Reactome:R-HSA-8987096 \"IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987129 \"JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated\"", "Reactome:R-HSA-8987141 \"IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987150 \"IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3\"", "Reactome:R-HSA-8987179 \"IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3\"", "Reactome:R-HSA-8987202 \"IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2\"", "Reactome:R-HSA-8987255 \"IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3\"" ], "previous": [ "EC:2.7.10.1", "MetaCyc:2.7.10.1-RXN", "Reactome:R-HSA-166544 \"TrkA receptor autophosphorylates\"", "Reactome:R-HSA-167019 \"SHC, complexed with TrkA, is tyrosine-phosphorylated\"", "Reactome:R-HSA-167683 \"TrkA phosphorylates PLCG1\"", "Reactome:R-HSA-169905 \"ARMS is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-177933 \"SHC1 phosphorylation by phosphorylated EGFR\"", "Reactome:R-HSA-198295 \"TRKA phosphorylates IRS\"", "Reactome:R-HSA-6784324 \"p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA\"", "Reactome:R-HSA-74711 \"Phosphorylation of IRS\"", "Reactome:R-HSA-74742 \"Phosphorylation of SHC1\"", "Reactome:R-HSA-8852552 \"MST1R autophosphorylates\"", "Reactome:R-HSA-8853792 \"RET tyrosine phosphorylation\"", "Reactome:R-HSA-8950269 \"STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor\"", "Reactome:R-HSA-8950340 \"IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation\"", "Reactome:R-HSA-8950354 \"STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction\"", "Reactome:R-HSA-8950364 \"IL23R in IL23:IL23 receptor complex is phosphorylated\"", "Reactome:R-HSA-8950405 \"JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated\"", "Reactome:R-HSA-8950423 \"JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated\"", "Reactome:R-HSA-8950453 \"JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4\"", "Reactome:R-HSA-8950485 \"STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction\"", "Reactome:R-HSA-8950537 \"JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated\"", "Reactome:R-HSA-8950591 \"JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated\"", "Reactome:R-HSA-8950757 \"IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated\"", "Reactome:R-HSA-8982163 \"IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8983300 \"IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1\"", "Reactome:R-HSA-8983309 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1\"", "Reactome:R-HSA-8983371 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5\"", "Reactome:R-HSA-8983424 \"IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2\"", "Reactome:R-HSA-8986985 \"IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5\"", "Reactome:R-HSA-8986994 \"IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2\"", "Reactome:R-HSA-8986995 \"IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA\"", "Reactome:R-HSA-8987012 \"IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1\"", "Reactome:R-HSA-8987040 \"IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1\"", "Reactome:R-HSA-8987042 \"IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2\"", "Reactome:R-HSA-8987070 \"IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987084 \"IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1\"", "Reactome:R-HSA-8987096 \"IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987129 \"JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated\"", "Reactome:R-HSA-8987141 \"IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3\"", "Reactome:R-HSA-8987150 \"IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3\"", "Reactome:R-HSA-8987179 \"IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3\"", "Reactome:R-HSA-8987202 \"IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2\"", "Reactome:R-HSA-8987255 \"IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3\"" ] } } }, { "id": "GO:0004722", "name": "protein serine/threonine phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.16", "MetaCyc:3.1.3.16-RXN", "Reactome:R-HSA-1295632 \"PPA2A dephosphorylates SPRY2\"", "Reactome:R-HSA-163568 \"phosphorylated perilipin + H2O -> perilipin + orthophosphate\"", "Reactome:R-HSA-163689 \"Dephosphorylation of pChREBP (Ser 196) by PP2A\"", "Reactome:R-HSA-163750 \"Dephosphorylation of phosphoPFKFB1 by PP2A complex\"", "Reactome:R-HSA-1638821 \"PP2A-B56 dephosphorylates centromeric cohesin\"", "Reactome:R-HSA-199425 \"PHLPP dephosphorylates S473 in AKT\"", "Reactome:R-HSA-199959 \"ERKs are inactivated by protein phosphatase 2A\"", "Reactome:R-HSA-201787 \"PPP3 complex dephosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-201790 \"DARPP-32 is dephosphorylated on Thr75 by PP2A\"", "Reactome:R-HSA-209055 \"PPM1A dephosphorylates nuclear SMAD2/3\"", "Reactome:R-HSA-2187401 \"MTMR4 dephosphorylates SMAD2/3\"", "Reactome:R-HSA-2995388 \"PP2A dephosphorylates BANF1\"", "Reactome:R-HSA-3002811 \"Myosin phosphatase dephosphorylates PLK1\"", "Reactome:R-HSA-3601585 \"PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex\"", "Reactome:R-HSA-380949 \"AMPK is dephosphorylated\"", "Reactome:R-HSA-4088141 \"PP2A-PPP2R2A dephosphorylates FOXM1\"", "Reactome:R-HSA-429730 \"PPM1L dephosphorylates multiphospho-CERT1-2\"", "Reactome:R-HSA-4419948 \"CTDNEP1:CNEP1R1 dephosphorylates LPIN\"", "Reactome:R-HSA-5672957 \"PP2A dephosphorylates KSR1\"", "Reactome:R-HSA-5672961 \"PP2A dephosphorylates inactive RAFs\"", "Reactome:R-HSA-5675431 \"PP2A dephosphorylates RAF1\"", "Reactome:R-HSA-5675433 \"PP5 dephosphorylates RAF1 S338\"", "Reactome:R-HSA-5679206 \"MTMR14, MTMR3 dephosphorylate PI3P\"", "Reactome:R-HSA-5683405 \"PPP5C dephosphorylates TP53BP1\"", "Reactome:R-HSA-5687758 \"PPP4C:PPP4R2 dephosphorylates RPA2\"", "Reactome:R-HSA-5692754 \"CDC14A,B dephosphorylate p-3S,T MAPK6\"", "Reactome:R-HSA-5693153 \"PPM1K dephosphorylates p-BCKDH\"", "Reactome:R-HSA-5694421 \"PP6 dephosphorylates SEC24\"", "Reactome:R-HSA-6792863 \"PP2A-PP2R5C dephosphorylates MDM2\"", "Reactome:R-HSA-6811504 \"AKT1 dephosphorylation by PP2A-B56-beta,gamma\"", "Reactome:R-HSA-74948 \"PP2A dephosphorylates p-RHO to RHO\"", "Reactome:R-HSA-8948139 \"p-S13-FUNDC1 is dephosphorylated by PGAM5\"", "Reactome:R-HSA-9619430 \"PPM1E dephosphorylates CAMK4\"", "Reactome:R-HSA-9619449 \"PPM1F dephosphorylates p-T286-CaMKII\"", "Reactome:R-HSA-9619467 \"PPM1F dephosphorylates CAMK1\"", "Reactome:R-HSA-9658445 \"MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs\"", "Reactome:R-HSA-9660536 \"SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex\"", "Reactome:R-HSA-9660538 \"Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs\"", "Reactome:R-HSA-9686524 \"PP6-PPP6R3 dephosphorylates TERF2\"", "Reactome:R-HSA-9831948 \"P:PP1 dephosphorylates M2-1\"" ], "previous": [ "EC:3.1.3.16", "MetaCyc:3.1.3.16-RXN", "Reactome:R-HSA-1295632 \"PPA2A dephosphorylates SPRY2\"", "Reactome:R-HSA-163568 \"phosphorylated perilipin + H2O -> perilipin + orthophosphate\"", "Reactome:R-HSA-1638821 \"PP2A-B56 dephosphorylates centromeric cohesin\"", "Reactome:R-HSA-199425 \"PHLPP dephosphorylates S473 in AKT\"", "Reactome:R-HSA-199959 \"ERKs are inactivated by protein phosphatase 2A\"", "Reactome:R-HSA-201787 \"PPP3 complex dephosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-201790 \"DARPP-32 is dephosphorylated on Thr75 by PP2A\"", "Reactome:R-HSA-209055 \"PPM1A dephosphorylates nuclear SMAD2/3\"", "Reactome:R-HSA-2187401 \"MTMR4 dephosphorylates SMAD2/3\"", "Reactome:R-HSA-2995388 \"PP2A dephosphorylates BANF1\"", "Reactome:R-HSA-3002811 \"Myosin phosphatase dephosphorylates PLK1\"", "Reactome:R-HSA-3601585 \"PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex\"", "Reactome:R-HSA-380949 \"AMPK is dephosphorylated\"", "Reactome:R-HSA-4088141 \"PP2A-PPP2R2A dephosphorylates FOXM1\"", "Reactome:R-HSA-429730 \"multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate\"", "Reactome:R-HSA-4419948 \"CTDNEP1:CNEP1R1 dephosphorylates LPIN\"", "Reactome:R-HSA-5672957 \"PP2A dephosphorylates KSR1\"", "Reactome:R-HSA-5672961 \"PP2A dephosphorylates inactive RAFs\"", "Reactome:R-HSA-5675431 \"PP2A dephosphorylates RAF1\"", "Reactome:R-HSA-5675433 \"PP5 dephosphorylates RAF1 S338\"", "Reactome:R-HSA-5679206 \"MTMR14, MTMR3 dephosphorylate PI3P\"", "Reactome:R-HSA-5683405 \"PPP5C dephosphorylates TP53BP1\"", "Reactome:R-HSA-5687758 \"PPP4C:PPP4R2 dephosphorylates RPA2\"", "Reactome:R-HSA-5692754 \"CDC14A,B dephosphorylate p-3S,T MAPK6\"", "Reactome:R-HSA-5693153 \"PPM1K dephosphorylates p-BCKDH\"", "Reactome:R-HSA-5694421 \"PP6 dephosphorylates SEC24\"", "Reactome:R-HSA-6792863 \"PP2A-PP2R5C dephosphorylates MDM2\"", "Reactome:R-HSA-6811504 \"AKT1 dephosphorylation by PP2A-B56-beta,gamma\"", "Reactome:R-HSA-74948 \"PP2A dephosphorylates p-RHO to RHO\"", "Reactome:R-HSA-8948139 \"p-S13-FUNDC1 is dephosphorylated by PGAM5\"", "Reactome:R-HSA-9619430 \"PPM1E dephosphorylates CAMK4\"", "Reactome:R-HSA-9619449 \"PPM1F dephosphorylates p-T286-CaMKII\"", "Reactome:R-HSA-9619467 \"PPM1F dephosphorylates CAMK1\"", "Reactome:R-HSA-9658445 \"MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs\"", "Reactome:R-HSA-9660536 \"SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex\"", "Reactome:R-HSA-9660538 \"Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs\"", "Reactome:R-HSA-9686524 \"PP6-PPP6R3 dephosphorylates TERF2\"" ] } } }, { "id": "GO:0004725", "name": "protein tyrosine phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.48", "MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN", "Reactome:R-HSA-1169188 \"SHP1 (PTPN6) dephosphorylates JAK2\"", "Reactome:R-HSA-1169192 \"PTP1B dephosphorylates GHR\"", "Reactome:R-HSA-1169210 \"PTP1B dephosphorylates JAK2\"", "Reactome:R-HSA-1549564 \"PPTN11 dephosphorylates SPRY2\"", "Reactome:R-HSA-202214 \"Dephosphorylation of Lck-pY505 by CD45\"", "Reactome:R-HSA-203797 \"ERKs are inactivated by dual-specific phosphatases (DUSPs)\"", "Reactome:R-HSA-377643 \"Dephosphorylation of inactive SRC by PTPB1\"", "Reactome:R-HSA-389758 \"Dephosphorylation of CD3-zeta by PD-1 bound phosphatases\"", "Reactome:R-HSA-391868 \"Dephosphorylation of NCAM1 bound pFyn\"", "Reactome:R-HSA-445089 \"Dephosphorylation of pL1 (Y1176)\"", "Reactome:R-HSA-5683967 \"EYA1-4 dephosphorylates tyrosine Y142 of H2AFX\"", "Reactome:R-HSA-6807008 \"PTPRJ dephosphorylates MET\"", "Reactome:R-HSA-6807027 \"PTPN1 and PTPN2 dephosphorylate MET\"", "Reactome:R-HSA-74733 \"Insulin receptor de-phosphorylation\"", "Reactome:R-HSA-74747 \"Dephosphorylation of p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-74748 \"De-phosphorylation of p-Y427-SHC1\"", "Reactome:R-HSA-877308 \"Dephosphorylation of JAKs by PTPs\"", "Reactome:R-HSA-8849435 \"PTPN1 dephosphorylates PTK6\"", "Reactome:R-HSA-8852200 \"Inactivation of LCK by PTPN22\"", "Reactome:R-HSA-8855381 \"PTPN22 dephosphorylates ZAP70\"", "Reactome:R-HSA-8863804 \"PTPN12 dephosphorylates ERBB2 on tyrosine Y1248\"", "Reactome:R-HSA-8864029 \"PTPN12 dephosphorylates EGFR at Y1172 (Y1148)\"", "Reactome:R-HSA-8864036 \"PTPN12 dephosphorylates PDGFRB at Y1021\"", "Reactome:R-HSA-8864125 \"PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248\"", "Reactome:R-HSA-8867047 \"PTPN3 dephosphorylates EPS15\"", "Reactome:R-HSA-8867658 \"PTPN3 dephosphorylates MAPK12\"", "Reactome:R-HSA-8937767 \"PTPN11 dephosphorylates RUNX1\"", "Reactome:R-HSA-914036 \"SHP1 and SHP2 dephosphorylate Y628 of IL3RB\"", "Reactome:R-HSA-9603719 \"Protein tyrosine phosphatases dephosphorylate NTRK3\"", "Reactome:R-HSA-9635461 \"PtpA dephosphorylates GSK3A\"", "Reactome:R-HSA-9636439 \"PtpA:Ub dephosphorylates p-Y133-VPS33B\"", "Reactome:R-HSA-9674816 \"p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS\"", "Reactome:R-HSA-9698408 \"PTPRJ dephosphorylates active FLT3\"", "Reactome:R-HSA-9700200 \"PTPRZ dephosphorylates ligand-bound ALK dimers\"", "Reactome:R-HSA-9701507 \"PTPN6 dephosphorylates JAK3\"", "Reactome:R-HSA-997309 \"Dephosphorylation of STAT1 by SHP2\"", "Reactome:R-HSA-997311 \"Dephosphorylation of TYK2 by PTP1B\"", "Reactome:R-HSA-997314 \"Dephosphorylation of JAK1 by SHP1\"", "Reactome:R-HSA-997326 \"Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP\"", "RHEA:10684" ], "previous": [ "EC:3.1.3.48", "MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN", "Reactome:R-HSA-1169188 \"SHP1 (PTPN6) dephosphorylates JAK2\"", "Reactome:R-HSA-1169192 \"PTP1B dephosphorylates GHR\"", "Reactome:R-HSA-1169210 \"PTP1B dephosphorylates JAK2\"", "Reactome:R-HSA-1549564 \"PPTN11 dephosphorylates SPRY2\"", "Reactome:R-HSA-202214 \"Dephosphorylation of Lck-pY505 by CD45\"", "Reactome:R-HSA-203797 \"ERKs are inactivated by dual-specific phosphatases (DUSPs)\"", "Reactome:R-HSA-377643 \"Dephosphorylation of inactive SRC by PTPB1\"", "Reactome:R-HSA-389758 \"Dephosphorylation of CD3-zeta by PD-1 bound phosphatases\"", "Reactome:R-HSA-391868 \"Dephosphorylation of NCAM1 bound pFyn\"", "Reactome:R-HSA-445089 \"Dephosphorylation of pL1 (Y1176)\"", "Reactome:R-HSA-5683967 \"EYA1-4 dephosphorylates tyrosine Y142 of H2AFX\"", "Reactome:R-HSA-6807008 \"PTPRJ dephosphorylates MET\"", "Reactome:R-HSA-6807027 \"PTPN1 and PTPN2 dephosphorylate MET\"", "Reactome:R-HSA-74733 \"Insulin receptor de-phosphorylation\"", "Reactome:R-HSA-74747 \"Dephosphorylation of p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-74748 \"De-phosphorylation of p-Y427-SHC1\"", "Reactome:R-HSA-877308 \"Dephosphorylation of JAKs by PTPs\"", "Reactome:R-HSA-8849435 \"PTPN1 dephosphorylates PTK6\"", "Reactome:R-HSA-8852200 \"Inactivation of LCK by PTPN22\"", "Reactome:R-HSA-8855381 \"PTPN22 dephosphorylates ZAP70\"", "Reactome:R-HSA-8863804 \"PTPN12 dephosphorylates ERBB2 on tyrosine Y1248\"", "Reactome:R-HSA-8864029 \"PTPN12 dephosphorylates EGFR at Y1148 (Y1172)\"", "Reactome:R-HSA-8864036 \"PTPN12 dephosphorylates PDGFRB at Y1021\"", "Reactome:R-HSA-8864125 \"PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248\"", "Reactome:R-HSA-8867047 \"PTPN3 dephosphorylates EPS15\"", "Reactome:R-HSA-8867658 \"PTPN3 dephosphorylates MAPK12\"", "Reactome:R-HSA-8937767 \"PTPN11 dephosphorylates RUNX1\"", "Reactome:R-HSA-914036 \"SHP1 and SHP2 dephosphorylate Y628 of IL3RB\"", "Reactome:R-HSA-9603719 \"Protein tyrosine phosphatases dephosphorylate NTRK3\"", "Reactome:R-HSA-9635461 \"PtpA dephosphorylates GSK3A\"", "Reactome:R-HSA-9636439 \"PtpA:Ub dephosphorylates p-Y133-VPS33B\"", "Reactome:R-HSA-9674816 \"p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS\"", "Reactome:R-HSA-9698408 \"PTPRJ dephosphorylates active FLT3\"", "Reactome:R-HSA-9700200 \"PTPRZ dephosphorylates ligand-bound ALK dimers\"", "Reactome:R-HSA-9701507 \"PTPN6 dephosphorylates JAK3\"", "Reactome:R-HSA-997309 \"Dephosphorylation of STAT1 by SHP2\"", "Reactome:R-HSA-997311 \"Dephosphorylation of TYK2 by PTP1B\"", "Reactome:R-HSA-997314 \"Dephosphorylation of JAK1 by SHP1\"", "Reactome:R-HSA-997326 \"Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP\"", "RHEA:10684" ] } } }, { "id": "GO:0004738", "name": "pyruvate dehydrogenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-71397 \"lipo-PDH decarboxylates PYR to Ac-CoA\"" ], "previous": [ "MetaCyc:RXN0-1134", "Reactome:R-HSA-71397 \"lipo-PDH decarboxylates PYR to Ac-CoA\"" ] } } }, { "id": "GO:0004739", "name": "pyruvate dehydrogenase (acetyl-transferring) activity", "changes": { "xrefs": { "current": [ "EC:1.2.4.1", "MetaCyc:RXN0-1134", "RHEA:19189" ], "previous": [ "EC:1.2.4.1", "RHEA:19189" ] } } }, { "id": "GO:0004743", "name": "pyruvate kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.40", "MetaCyc:PEPDEPHOS-RXN", "Reactome:R-HSA-71670 \"phosphoenolpyruvate + ADP => pyruvate + ATP\"", "RHEA:18159" ], "previous": [ "EC:2.7.1.40", "MetaCyc:PEPDEPHOS-RXN", "Reactome:R-HSA-71670 \"phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens\"", "RHEA:18159" ] } } }, { "id": "GO:0004758", "name": "serine C-palmitoyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.50", "KEGG_REACTION:R01281", "MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN", "Reactome:R-HSA-428127 \"SPTLC complexes transfer acyl-CoA onto serine\"", "RHEA:14761" ], "previous": [ "EC:2.3.1.50", "KEGG_REACTION:R01281", "MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN", "Reactome:R-HSA-428127 \"palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2\"", "RHEA:14761" ] } } }, { "id": "GO:0004767", "name": "sphingomyelin phosphodiesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.4.12", "KEGG_REACTION:R02541", "MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN", "Reactome:R-HSA-1605797 \"SMPD1 hydrolyzes SPHM\"", "Reactome:R-HSA-1606273 \"SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)\"", "Reactome:R-HSA-1606288 \"SMPD4 hydrolyzes sphingomyelin (ER membrane)\"", "Reactome:R-HSA-1640164 \"ENPP7 hydrolyzes sphingomyelin\"", "Reactome:R-HSA-193706 \"Production of ceramide which can activate JNK and other targets\"", "RHEA:19253" ], "previous": [ "EC:3.1.4.12", "KEGG_REACTION:R02541", "MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN", "Reactome:R-HSA-1605797 \"Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)\"", "Reactome:R-HSA-1606273 \"Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)\"", "Reactome:R-HSA-1606288 \"Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)\"", "Reactome:R-HSA-1640164 \"Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin\"", "Reactome:R-HSA-193706 \"Production of ceramide which can activate JNK and other targets\"", "RHEA:19253" ] } } }, { "id": "GO:0004773", "name": "steryl-sulfatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.6.2", "MetaCyc:STERYL-SULFATASE-RXN", "Reactome:R-HSA-1606839 \"ARSC hydrolyzes steroid sulfates\"", "RHEA:19873" ], "previous": [ "EC:3.1.6.2", "MetaCyc:STERYL-SULFATASE-RXN", "Reactome:R-HSA-1606839 \"Steryl sulfatase hydrolyses sulfate from steroid sulfates\"", "RHEA:19873" ] } } }, { "id": "GO:0004842", "name": "ubiquitin-protein transferase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R03876", "Reactome:R-HSA-1169394 \"ISGylation of IRF3\"", "Reactome:R-HSA-1169395 \"ISGylation of viral protein NS1\"", "Reactome:R-HSA-1169397 \"Activation of ISG15 by UBA7 E1 ligase\"", "Reactome:R-HSA-1169398 \"ISGylation of host protein filamin B\"", "Reactome:R-HSA-1169402 \"ISGylation of E2 conjugating enzymes\"", "Reactome:R-HSA-1169405 \"ISGylation of protein phosphatase 1 beta (PP2CB)\"", "Reactome:R-HSA-1169406 \"ISGylation of host proteins\"", "Reactome:R-HSA-1234163 \"Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha\"", "Reactome:R-HSA-1234172 \"Nuclear VBC complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-1253282 \"ERBB4 ubiquitination by WWP1/ITCH\"", "Reactome:R-HSA-1358789 \"Self-ubiquitination of RNF41\"", "Reactome:R-HSA-1358790 \"RNF41 ubiquitinates ERBB3\"", "Reactome:R-HSA-1358792 \"RNF41 ubiquitinates activated ERBB3\"", "Reactome:R-HSA-1363331 \"Ubiquitination of p130 (RBL2) by SCF (Skp2)\"", "Reactome:R-HSA-168915 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-173542 \"SMURF2 ubiquitinates SMAD2\"", "Reactome:R-HSA-173545 \"Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling\"", "Reactome:R-HSA-174057 \"Multiubiquitination of APC/C-associated Cdh1\"", "Reactome:R-HSA-174104 \"Ubiquitination of Cyclin A by APC/C:Cdc20 complex\"", "Reactome:R-HSA-174144 \"Ubiquitination of Securin by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-174159 \"Ubiquitination of Emi1 by SCF-beta-TrCP\"", "Reactome:R-HSA-174195 \"Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex\"", "Reactome:R-HSA-174227 \"Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-179417 \"Multiubiquitination of Nek2A\"", "Reactome:R-HSA-180540 \"Multi-ubiquitination of APOBEC3G\"", "Reactome:R-HSA-180597 \"Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex\"", "Reactome:R-HSA-182986 \"CBL-mediated ubiquitination of CIN85\"", "Reactome:R-HSA-182993 \"Ubiquitination of stimulated EGFR (CBL)\"", "Reactome:R-HSA-183051 \"CBL ubiquitinates Sprouty\"", "Reactome:R-HSA-183084 \"CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix\"", "Reactome:R-HSA-183089 \"CBL binds and ubiquitinates phosphorylated Sprouty\"", "Reactome:R-HSA-1852623 \"Ubiquitination of NICD1 by FBWX7\"", "Reactome:R-HSA-187575 \"Ubiquitination of phospho-p27/p21\"", "Reactome:R-HSA-1912357 \"ITCH ubiquitinates DTX\"", "Reactome:R-HSA-1912386 \"Ubiquitination of NOTCH1 by ITCH in the absence of ligand\"", "Reactome:R-HSA-1918092 \"CHIP (STUB1) mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1918095 \"CUL5 mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1977296 \"NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer\"", "Reactome:R-HSA-1980074 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1\"", "Reactome:R-HSA-1980118 \"ARRB mediates NOTCH1 ubiquitination\"", "Reactome:R-HSA-201425 \"Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling\"", "Reactome:R-HSA-202453 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-202534 \"Ubiquitination of NEMO by TRAF6\"", "Reactome:R-HSA-205118 \"TRAF6 polyubiquitinates NRIF\"", "Reactome:R-HSA-209063 \"Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex\"", "Reactome:R-HSA-211734 \"Ubiquitination of PAK-2p34\"", "Reactome:R-HSA-2169050 \"SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7\"", "Reactome:R-HSA-2172172 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH2\"", "Reactome:R-HSA-2179276 \"SMURF2 monoubiquitinates SMAD3\"", "Reactome:R-HSA-2186747 \"Ubiquitination of SKI/SKIL by RNF111/SMURF2\"", "Reactome:R-HSA-2186785 \"RNF111 ubiquitinates SMAD7\"", "Reactome:R-HSA-2187368 \"STUB1 (CHIP) ubiquitinates SMAD3\"", "Reactome:R-HSA-2213017 \"Auto-ubiquitination of TRAF3\"", "Reactome:R-HSA-264444 \"Autoubiquitination of phospho-COP1(Ser-387 )\"", "Reactome:R-HSA-2682349 \"RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels\"", "Reactome:R-HSA-2730904 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-2737728 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants\"", "Reactome:R-HSA-2769007 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants\"", "Reactome:R-HSA-2900765 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants\"", "Reactome:R-HSA-3000335 \"SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA\"", "Reactome:R-HSA-3134804 \"STING ubiquitination by TRIM32 or TRIM56\"", "Reactome:R-HSA-3134946 \"DDX41 ubiquitination by TRIM21\"", "Reactome:R-HSA-3249386 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1\"", "Reactome:R-HSA-3780995 \"NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2\"", "Reactome:R-HSA-3781009 \"NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1\"", "Reactome:R-HSA-3788724 \"Cdh1:APC/C ubiquitinates EHMT1 and EHMT2\"", "Reactome:R-HSA-3797226 \"Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)\"", "Reactome:R-HSA-400267 \"BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins\"", "Reactome:R-HSA-4332236 \"CBL neddylates TGFBR2\"", "Reactome:R-HSA-446877 \"TRAF6 is K63 poly-ubiquitinated\"", "Reactome:R-HSA-450358 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation\"", "Reactome:R-HSA-451418 \"Pellino ubiquitinates IRAK1\"", "Reactome:R-HSA-5205682 \"Parkin promotes the ubiquitination of mitochondrial substrates\"", "Reactome:R-HSA-5357757 \"BIRC(cIAP1/2) ubiquitinates RIPK1\"", "Reactome:R-HSA-5362412 \"SYVN1 ubiquitinates Hh C-terminal fragments\"", "Reactome:R-HSA-5483238 \"Hh processing variants are ubiquitinated\"", "Reactome:R-HSA-5607725 \"SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP\"", "Reactome:R-HSA-5607728 \"beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex\"", "Reactome:R-HSA-5607756 \"TRAF6 oligomer autoubiquitinates\"", "Reactome:R-HSA-5607757 \"K63polyUb-TRAF6 ubiquitinates TAK1\"", "Reactome:R-HSA-5610742 \"SCF(beta-TrCP) ubiquitinates p-GLI1\"", "Reactome:R-HSA-5610745 \"SCF(beta-TrCP) ubiquitinates p-GLI2\"", "Reactome:R-HSA-5610746 \"SCF(beta-TrCP) ubiquitinates p-GLI3\"", "Reactome:R-HSA-5652009 \"RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA\"", "Reactome:R-HSA-5655170 \"RCHY1 monoubiquitinates POLH\"", "Reactome:R-HSA-5660753 \"SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA\"", "Reactome:R-HSA-5667107 \"SIAH1, SIAH2 ubiquitinate SNCAIP\"", "Reactome:R-HSA-5667111 \"PARK2 K63-Ubiquitinates SNCAIP\"", "Reactome:R-HSA-5668454 \"K63polyUb-cIAP1,2 ubiquitinates TRAF3\"", "Reactome:R-HSA-5668534 \"cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK\"", "Reactome:R-HSA-5675470 \"BIRC2/3 (cIAP1/2) is autoubiquitinated\"", "Reactome:R-HSA-5684250 \"SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2\"", "Reactome:R-HSA-5691108 \"SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2\"", "Reactome:R-HSA-5693108 \"TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains\"", "Reactome:R-HSA-68712 \"The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1\"", "Reactome:R-HSA-69598 \"Ubiquitination of phosphorylated Cdc25A\"", "Reactome:R-HSA-741386 \"RIP2 induces K63-linked ubiquitination of NEMO\"", "Reactome:R-HSA-75824 \"Ubiquitination of Cyclin D1\"", "Reactome:R-HSA-870449 \"TRIM33 monoubiquitinates SMAD4\"", "Reactome:R-HSA-8948709 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3\"", "Reactome:R-HSA-8956106 \"VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-9013069 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH3\"", "Reactome:R-HSA-9013974 \"Auto-ubiquitination of TRAF3 within activated TLR3 complex\"", "Reactome:R-HSA-9014342 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-918224 \"DDX58 is K63 polyubiquitinated\"", "Reactome:R-HSA-936412 \"RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS\"", "Reactome:R-HSA-936942 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2\"", "Reactome:R-HSA-936986 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains\"", "Reactome:R-HSA-9628444 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation\"", "Reactome:R-HSA-9645394 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation\"", "Reactome:R-HSA-9645414 \"Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer\"", "Reactome:R-HSA-9688831 \"STUB1 ubiquitinates RIPK3 at K55, K363\"", "Reactome:R-HSA-9701000 \"BRCA1:BARD1 heterodimer autoubiquitinates\"", "Reactome:R-HSA-9750946 \"TRAF2,6 ubiquitinates NLRC5\"", "Reactome:R-HSA-975118 \"TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex\"", "Reactome:R-HSA-975147 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane\"", "Reactome:R-HSA-9758604 \"Ubiquitination of IKBKG by TRAF6\"", "Reactome:R-HSA-9793444 \"ITCH polyubiquitinates MLKL at K50\"", "Reactome:R-HSA-9793485 \"PRKN polyubiquitinates RIPK3\"", "Reactome:R-HSA-9793679 \"LUBAC ubiquitinates RIPK1 at K627\"", "Reactome:R-HSA-9796346 \"MIB2 ubiquitinates RIPK1 at K377, K604, K634\"", "Reactome:R-HSA-9796387 \"STUB1 ubiquitinates RIPK1 at K571, K604, K627\"", "Reactome:R-HSA-9796626 \"MIB2 ubiquitinates CFLAR\"", "Reactome:R-HSA-9815507 \"MIB2 ubiquitinates CYLD at K338, K530\"", "Reactome:R-HSA-9817362 \"SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex\"", "Reactome:R-HSA-983140 \"Transfer of Ub from E2 to substrate and release of E2\"", "Reactome:R-HSA-983153 \"E1 mediated ubiquitin activation\"", "Reactome:R-HSA-983156 \"Polyubiquitination of substrate\"", "Reactome:R-HSA-9833155 \"Ubiquitination of STAT2\"", "Reactome:R-HSA-9833973 \"ISGylation of PKR\"" ], "previous": [ "KEGG_REACTION:R03876", "Reactome:R-HSA-1169394 \"ISGylation of IRF3\"", "Reactome:R-HSA-1169395 \"ISGylation of viral protein NS1\"", "Reactome:R-HSA-1169397 \"Activation of ISG15 by UBA7 E1 ligase\"", "Reactome:R-HSA-1169398 \"ISGylation of host protein filamin B\"", "Reactome:R-HSA-1169402 \"ISGylation of E2 conjugating enzymes\"", "Reactome:R-HSA-1169405 \"ISGylation of protein phosphatase 1 beta (PP2CB)\"", "Reactome:R-HSA-1169406 \"ISGylation of host proteins\"", "Reactome:R-HSA-1234163 \"Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha\"", "Reactome:R-HSA-1234172 \"Nuclear VBC complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-1253282 \"ERBB4 ubiquitination by WWP1/ITCH\"", "Reactome:R-HSA-1358789 \"Self-ubiquitination of RNF41\"", "Reactome:R-HSA-1358790 \"RNF41 ubiquitinates ERBB3\"", "Reactome:R-HSA-1358792 \"RNF41 ubiquitinates activated ERBB3\"", "Reactome:R-HSA-1363331 \"Ubiquitination of p130 (RBL2) by SCF (Skp2)\"", "Reactome:R-HSA-168915 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-173542 \"SMURF2 ubiquitinates SMAD2\"", "Reactome:R-HSA-173545 \"Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling\"", "Reactome:R-HSA-174057 \"Multiubiquitination of APC/C-associated Cdh1\"", "Reactome:R-HSA-174104 \"Ubiquitination of Cyclin A by APC/C:Cdc20 complex\"", "Reactome:R-HSA-174144 \"Ubiquitination of Securin by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-174159 \"Ubiquitination of Emi1 by SCF-beta-TrCP\"", "Reactome:R-HSA-174195 \"Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex\"", "Reactome:R-HSA-174227 \"Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-179417 \"Multiubiquitination of Nek2A\"", "Reactome:R-HSA-180540 \"Multi-ubiquitination of APOBEC3G\"", "Reactome:R-HSA-180597 \"Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex\"", "Reactome:R-HSA-182986 \"CBL-mediated ubiquitination of CIN85\"", "Reactome:R-HSA-182993 \"Ubiquitination of stimulated EGFR (CBL)\"", "Reactome:R-HSA-183036 \"Ubiquitination of stimulated EGFR (CBL:GRB2)\"", "Reactome:R-HSA-183051 \"CBL ubiquitinates Sprouty\"", "Reactome:R-HSA-183084 \"CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix\"", "Reactome:R-HSA-183089 \"CBL binds and ubiquitinates phosphorylated Sprouty\"", "Reactome:R-HSA-1852623 \"Ubiquitination of NICD1 by FBWX7\"", "Reactome:R-HSA-187575 \"Ubiquitination of phospho-p27/p21\"", "Reactome:R-HSA-1912357 \"ITCH ubiquitinates DTX\"", "Reactome:R-HSA-1912386 \"Ubiquitination of NOTCH1 by ITCH in the absence of ligand\"", "Reactome:R-HSA-1918092 \"CHIP (STUB1) mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1918095 \"CUL5 mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1977296 \"NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer\"", "Reactome:R-HSA-1980074 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1\"", "Reactome:R-HSA-1980118 \"ARRB mediates NOTCH1 ubiquitination\"", "Reactome:R-HSA-201425 \"Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling\"", "Reactome:R-HSA-202453 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-202534 \"Ubiquitination of NEMO by TRAF6\"", "Reactome:R-HSA-205118 \"TRAF6 polyubiquitinates NRIF\"", "Reactome:R-HSA-209063 \"Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex\"", "Reactome:R-HSA-211734 \"Ubiquitination of PAK-2p34\"", "Reactome:R-HSA-2169050 \"SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7\"", "Reactome:R-HSA-2172172 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH2\"", "Reactome:R-HSA-2179276 \"SMURF2 monoubiquitinates SMAD3\"", "Reactome:R-HSA-2186747 \"Ubiquitination of SKI/SKIL by RNF111/SMURF2\"", "Reactome:R-HSA-2186785 \"RNF111 ubiquitinates SMAD7\"", "Reactome:R-HSA-2187368 \"STUB1 (CHIP) ubiquitinates SMAD3\"", "Reactome:R-HSA-2213017 \"Auto-ubiquitination of TRAF3\"", "Reactome:R-HSA-264444 \"Autoubiquitination of phospho-COP1(Ser-387 )\"", "Reactome:R-HSA-2682349 \"RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels\"", "Reactome:R-HSA-2730904 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-2737728 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants\"", "Reactome:R-HSA-2769007 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants\"", "Reactome:R-HSA-2900765 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants\"", "Reactome:R-HSA-3000335 \"SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA\"", "Reactome:R-HSA-3134804 \"STING ubiquitination by TRIM32 or TRIM56\"", "Reactome:R-HSA-3134946 \"DDX41 ubiquitination by TRIM21\"", "Reactome:R-HSA-3249386 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1\"", "Reactome:R-HSA-3780995 \"NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2\"", "Reactome:R-HSA-3781009 \"NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1\"", "Reactome:R-HSA-3788724 \"Cdh1:APC/C ubiquitinates EHMT1 and EHMT2\"", "Reactome:R-HSA-3797226 \"Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)\"", "Reactome:R-HSA-400267 \"BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins\"", "Reactome:R-HSA-4332236 \"CBL neddylates TGFBR2\"", "Reactome:R-HSA-446877 \"TRAF6 is K63 poly-ubiquitinated\"", "Reactome:R-HSA-450358 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation\"", "Reactome:R-HSA-451418 \"Pellino ubiquitinates IRAK1\"", "Reactome:R-HSA-5205682 \"Parkin promotes the ubiquitination of mitochondrial substrates\"", "Reactome:R-HSA-5357757 \"BIRC(cIAP1/2) ubiquitinates RIPK1\"", "Reactome:R-HSA-5362412 \"SYVN1 ubiquitinates Hh C-terminal fragments\"", "Reactome:R-HSA-5483238 \"Hh processing variants are ubiquitinated\"", "Reactome:R-HSA-5607725 \"SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP\"", "Reactome:R-HSA-5607728 \"beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex\"", "Reactome:R-HSA-5607756 \"TRAF6 oligomer autoubiquitinates\"", "Reactome:R-HSA-5607757 \"K63polyUb-TRAF6 ubiquitinates TAK1\"", "Reactome:R-HSA-5610742 \"SCF(beta-TrCP) ubiquitinates p-GLI1\"", "Reactome:R-HSA-5610745 \"SCF(beta-TrCP) ubiquitinates p-GLI2\"", "Reactome:R-HSA-5610746 \"SCF(beta-TrCP) ubiquitinates p-GLI3\"", "Reactome:R-HSA-5652009 \"RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA\"", "Reactome:R-HSA-5655170 \"RCHY1 monoubiquitinates POLH\"", "Reactome:R-HSA-5660753 \"SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA\"", "Reactome:R-HSA-5667107 \"SIAH1, SIAH2 ubiquitinate SNCAIP\"", "Reactome:R-HSA-5667111 \"PARK2 K63-Ubiquitinates SNCAIP\"", "Reactome:R-HSA-5668454 \"K63polyUb-cIAP1,2 ubiquitinates TRAF3\"", "Reactome:R-HSA-5668534 \"cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK\"", "Reactome:R-HSA-5675470 \"BIRC2/3 (cIAP1/2) is autoubiquitinated\"", "Reactome:R-HSA-5684250 \"SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2\"", "Reactome:R-HSA-5691108 \"SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2\"", "Reactome:R-HSA-5693108 \"TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains\"", "Reactome:R-HSA-68712 \"The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1\"", "Reactome:R-HSA-69598 \"Ubiquitination of phosphorylated Cdc25A\"", "Reactome:R-HSA-741386 \"RIP2 induces K63-linked ubiquitination of NEMO\"", "Reactome:R-HSA-75824 \"Ubiquitination of Cyclin D1\"", "Reactome:R-HSA-870449 \"TRIM33 monoubiquitinates SMAD4\"", "Reactome:R-HSA-8948709 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3\"", "Reactome:R-HSA-8956106 \"VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-9013069 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH3\"", "Reactome:R-HSA-9013974 \"Auto-ubiquitination of TRAF3 within activated TLR3 complex\"", "Reactome:R-HSA-9014342 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-918224 \"DDX58 is K63 polyubiquitinated\"", "Reactome:R-HSA-936412 \"RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS\"", "Reactome:R-HSA-936942 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2\"", "Reactome:R-HSA-936986 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains\"", "Reactome:R-HSA-9628444 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation\"", "Reactome:R-HSA-9645394 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation\"", "Reactome:R-HSA-9645414 \"Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer\"", "Reactome:R-HSA-9688831 \"STUB1 ubiquitinates RIPK3 at K55, K363\"", "Reactome:R-HSA-9701000 \"BRCA1:BARD1 heterodimer autoubiquitinates\"", "Reactome:R-HSA-9750946 \"TRAF2,6 ubiquitinates NLRC5\"", "Reactome:R-HSA-975118 \"TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex\"", "Reactome:R-HSA-975147 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane\"", "Reactome:R-HSA-9758604 \"Ubiquitination of IKBKG by TRAF6\"", "Reactome:R-HSA-9793444 \"ITCH polyubiquitinates MLKL at K50\"", "Reactome:R-HSA-9793485 \"PRKN polyubiquitinates RIPK3\"", "Reactome:R-HSA-9793679 \"LUBAC ubiquitinates RIPK1 at K627\"", "Reactome:R-HSA-9796346 \"MIB2 ubiquitinates RIPK1 at K377, K604, K634\"", "Reactome:R-HSA-9796387 \"STUB1 ubiquitinates RIPK1 at K571, K604, K627\"", "Reactome:R-HSA-9796626 \"MIB2 ubiquitinates CFLAR\"", "Reactome:R-HSA-9815507 \"MIB2 ubiquitinates CYLD at K338, K530\"", "Reactome:R-HSA-9817362 \"SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex\"", "Reactome:R-HSA-983140 \"Transfer of Ub from E2 to substrate and release of E2\"", "Reactome:R-HSA-983153 \"E1 mediated ubiquitin activation\"", "Reactome:R-HSA-983156 \"Polyubiquitination of substrate\"" ] } } }, { "id": "GO:0004844", "name": "uracil DNA N-glycosylase activity", "changes": { "xrefs": { "current": [ "EC:3.2.2.27", "https://github.com/geneontology/go-ontology/issues/25051", "Reactome:R-HSA-110215 \"Cleavage of uracil by UNG glycosylase\"", "Reactome:R-HSA-110217 \"Cleavage of 5-hydroxyluracil by UNG glycosylase\"", "Reactome:R-HSA-9817512 \"UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3\"" ], "previous": [ "EC:3.2.2.27", "https://github.com/geneontology/go-ontology/issues/25051", "Reactome:R-HSA-110215 \"Cleavage of uracil by UNG glycosylase\"", "Reactome:R-HSA-110217 \"Cleavage of 5-hydroxyluracil by UNG glycosylase\"" ] } } }, { "id": "GO:0004848", "name": "ureidoglycolate hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.116", "KEGG_REACTION:R00469", "MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN", "RHEA:19809" ], "previous": [ "EC:3.5.3.19", "KEGG_REACTION:R00469", "MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN", "RHEA:19809" ] } } }, { "id": "GO:0005049", "name": "nuclear export signal receptor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-178215 \"SMAD7:SMURF1 complex is exported to the cytosol\"" ], "previous": "N/A" } } }, { "id": "GO:0005215", "name": "transporter activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-168313 \"Virion-associated M2 protein mediated ion infusion\"", "Reactome:R-HSA-178215 \"SMAD7:SMURF1 complex is exported to the cytosol\"" ] } } }, { "id": "GO:0005261", "name": "monoatomic cation channel activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1168376 \"STIM1 oligomerizes\"", "Reactome:R-HSA-1296043 \"Activation of HCN channels\"", "Reactome:R-HSA-169683 \"IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol\"", "Reactome:R-HSA-2089943 \"TRPC1 translocates calcium from the extracellular region to the cytosol\"", "Reactome:R-HSA-426223 \"Cation influx mediated by TRPC3/6/7\"", "Reactome:R-HSA-4420052 \"Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT\"", "Reactome:R-HSA-9706720 \"SARS-CoV-1 E transports Ca2+\"", "Reactome:R-HSA-9712190 \"cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol\"", "Reactome:R-HSA-9754616 \"SARS-CoV-2 E pentamer transports Ca2+\"", "Reactome:R-HSA-9837835 \"SH pentamer transports K+\"" ], "previous": [ "Reactome:R-HSA-1168376 \"STIM1 oligomerizes\"", "Reactome:R-HSA-1296043 \"Activation of HCN channels\"", "Reactome:R-HSA-169683 \"IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol\"", "Reactome:R-HSA-2089943 \"TRPC1 translocates calcium from the extracellular region to the cytosol\"", "Reactome:R-HSA-426223 \"Cation influx mediated by TRPC3/6/7\"", "Reactome:R-HSA-4420052 \"Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT\"", "Reactome:R-HSA-9706720 \"SARS-CoV-1 E transports Ca2+\"", "Reactome:R-HSA-9712190 \"cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol\"", "Reactome:R-HSA-9754616 \"SARS-CoV-2 E pentamer transports Ca2+\"" ] } } }, { "id": "GO:0008117", "name": "sphinganine-1-phosphate aldolase activity", "changes": { "xrefs": { "current": [ "EC:4.1.2.27", "MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN", "Reactome:R-HSA-428681 \"PXLP-SGPL1 cleaves sphingoid-1-phosphates\"", "RHEA:18593" ], "previous": [ "EC:4.1.2.27", "MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN", "Reactome:R-HSA-428676 \"sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal\"", "Reactome:R-HSA-428681 \"sphinganine 1-phosphate => phosphoethanolamine + hexadecanal\"", "RHEA:18593" ] } } }, { "id": "GO:0008120", "name": "ceramide glucosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.80", "MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN", "Reactome:R-HSA-1638104 \"UGCG transfers glucose to ceramide\"", "RHEA:12088" ], "previous": [ "EC:2.4.1.80", "MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN", "Reactome:R-HSA-1638104 \"Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide\"", "RHEA:12088" ] } } }, { "id": "GO:0008131", "name": "primary amine oxidase activity", "changes": { "xrefs": { "current": [ "EC:1.4.3.21", "KEGG_REACTION:R01853", "MetaCyc:RXN-9597", "Reactome:R-HSA-141186 \"MAOA:FAD oxidatively deaminates of 5HT\"", "Reactome:R-HSA-141200 \"MAOB:FAD oxidatively deaminates of PEA\"", "Reactome:R-HSA-141202 \"MAOB:FAD oxidatively deaminates TYR\"", "Reactome:R-HSA-374909 \"Catabolism of Noradrenaline\"", "Reactome:R-HSA-379382 \"MAOA:FAD deaminates DA to DOPAC\"", "Reactome:R-HSA-379395 \"MAOA:FAD deaminates 3MT to HVA\"", "Reactome:R-HSA-5603108 \"Defective MAOA does not oxidatively deaminate 5HT\"", "Reactome:R-HSA-5696146 \"AOC2 deaminates TYR\"", "Reactome:R-HSA-5696183 \"AOC3 deaminates BZAM\"" ], "previous": [ "EC:1.4.3.21", "KEGG_REACTION:R01853", "MetaCyc:RXN-9597", "Reactome:R-HSA-141186 \"MAOA:FAD oxidatively deaminates of 5HT\"", "Reactome:R-HSA-141200 \"MAOB:FAD oxidatively deaminates of PEA\"", "Reactome:R-HSA-141202 \"MAOB:FAD oxidatively deaminates TYR\"", "Reactome:R-HSA-374909 \"Metabolism of Noradrenaline\"", "Reactome:R-HSA-379382 \"MAOA:FAD deaminates DA to DOPAC\"", "Reactome:R-HSA-379395 \"MAOA:FAD deaminates 3MT to HVA\"", "Reactome:R-HSA-5603108 \"Defective MAOA does not oxidatively deaminate 5HT\"", "Reactome:R-HSA-5696146 \"AOC2 deaminates TYR\"", "Reactome:R-HSA-5696183 \"AOC3 deaminates BZAM\"" ] } } }, { "id": "GO:0008177", "name": "succinate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.3.5.1", "KEGG_REACTION:R02164", "MetaCyc:RXN-14971", "Reactome:R-HSA-163213 \"Transfer of electrons through the succinate dehydrogenase complex\"", "Reactome:R-HSA-70994 \"Succinate <=> Fumarate (with FAD redox reaction on enzyme)\"", "RHEA:40523" ], "previous": [ "EC:1.3.5.1", "KEGG_REACTION:R02164", "MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN", "Reactome:R-HSA-163213 \"Transfer of electrons through the succinate dehydrogenase complex\"", "Reactome:R-HSA-70994 \"Succinate <=> Fumarate (with FAD redox reaction on enzyme)\"", "RHEA:13713" ] } } }, { "id": "GO:0008195", "name": "phosphatidate phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.4", "MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN", "Reactome:R-HSA-1483203 \"PA is dephosphorylated to DAG by LPIN\"", "Reactome:R-HSA-163688 \"Dephosphorylation of pChREBP (Thr 666) by PP2A\"", "Reactome:R-HSA-164056 \"Dephosphorylation of pChREBP (Ser 556) by PP2A\"", "Reactome:R-HSA-2029468 \"Conversion of PA into DAG by PAP-1\"", "Reactome:R-HSA-390329 \"Dephosphorylation of AKT by PP2A\"", "Reactome:R-HSA-5221130 \"LPIN catalyzes conversion of phosphatidic acid to diacylglycerol\"", "Reactome:R-HSA-6797630 \"LRPP4(LRPP1-3,5) hydrolyse LPA\"", "Reactome:R-HSA-75899 \"1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate\"", "RHEA:27429" ], "previous": [ "EC:3.1.3.4", "MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN", "Reactome:R-HSA-1483203 \"PA is dephosphorylated to DAG by LPIN\"", "Reactome:R-HSA-163688 \"Dephosphorylation of pChREBP (Thr 666) by PP2A\"", "Reactome:R-HSA-163689 \"Dephosphorylation of pChREBP (Ser 196) by PP2A\"", "Reactome:R-HSA-163750 \"Dephosphorylation of phosphoPFKFB1 by PP2A complex\"", "Reactome:R-HSA-164056 \"Dephosphorylation of pChREBP (Ser 568) by PP2A\"", "Reactome:R-HSA-2029468 \"Conversion of PA into DAG by PAP-1\"", "Reactome:R-HSA-390329 \"Dephosphorylation of AKT by PP2A\"", "Reactome:R-HSA-5221130 \"LPIN catalyzes conversion of phosphatidic acid to diacylglycerol\"", "Reactome:R-HSA-6797630 \"LRPP4(LRPP1-3,5) hydrolyse LPA\"", "Reactome:R-HSA-75899 \"1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate\"", "RHEA:27429" ] } } }, { "id": "GO:0008236", "name": "serine-type peptidase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1461993 \"pro-HD5 is cleaved by trypsin\"", "Reactome:R-HSA-2022383 \"Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)\"", "Reactome:R-HSA-3132753 \"Pancreatic proteases degrade TCN1:RCbl\"", "Reactome:R-HSA-6801766 \"Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)\"", "Reactome:R-HSA-9839072 \"HTRA2 degrades APP (Amyloid-beta precursor protein)\"", "Reactome:R-HSA-9839110 \"HTRA2 degrades NDUFA13 (GRIM-19)\"" ], "previous": [ "Reactome:R-HSA-1461993 \"pro-HD5 is cleaved by trypsin\"", "Reactome:R-HSA-2022383 \"Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)\"", "Reactome:R-HSA-3132753 \"Pancreatic proteases degrade TCN1:RCbl\"", "Reactome:R-HSA-6801766 \"Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)\"" ] } } }, { "id": "GO:0008237", "name": "metallopeptidase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-157629 \"NOTCH2-ligand complex is cleaved to produce NEXT2\"", "Reactome:R-HSA-157632 \"Complex of NOTCH1 with its ligand is cleaved to produce NEXT1\"", "Reactome:R-HSA-193679 \"alpha-secretase cleaves the p75NTR extracellular domain\"", "Reactome:R-HSA-2022368 \"MME:Zn2+ hydrolyses AGT(34-42)\"", "Reactome:R-HSA-2022393 \"ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)\"", "Reactome:R-HSA-2022396 \"MME:Zn2+ hydrolyses AGT(34-43)\"", "Reactome:R-HSA-2022399 \"ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)\"", "Reactome:R-HSA-2220944 \"ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants\"", "Reactome:R-HSA-2220976 \"NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding\"", "Reactome:R-HSA-2666278 \"NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1\"", "Reactome:R-HSA-2730752 \"NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding\"", "Reactome:R-HSA-3928660 \"ADAM10 cleaves EFNAs\"", "Reactome:R-HSA-5211340 \"Anthrax lef cleaves target cell MAP2K1 (MEK1)\"", "Reactome:R-HSA-5211356 \"Anthrax lef cleaves target cell MAP2K2 (MEK2)\"", "Reactome:R-HSA-5211387 \"Anthrax lef cleaves target cell MAP2K7 (MEK7)\"", "Reactome:R-HSA-5211391 \"Anthrax lef cleaves target cell MAP2K4 (MEK4)\"", "Reactome:R-HSA-5211400 \"Anthrax lef cleaves target cell MAP2K3 (MEK3)\"", "Reactome:R-HSA-5211405 \"Anthrax lef cleaves target cell MAP2K6 (MEK6)\"", "Reactome:R-HSA-8986181 \"PITRM1 proteolyzes mitochondrial targeting peptides (presequences)\"", "Reactome:R-HSA-9013284 \"NOTCH3-ligand complex is cleaved to produce NEXT3\"", "Reactome:R-HSA-9604264 \"ADAM10 cleaves NOTCH4\"", "Reactome:R-HSA-9662837 \"p-S,T-ADAM17(215-827):Zn2+ cleaves CD163\"", "Reactome:R-HSA-9759522 \"Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform\"" ], "previous": [ "Reactome:R-HSA-157629 \"NOTCH2-ligand complex is cleaved to produce NEXT2\"", "Reactome:R-HSA-157632 \"Complex of NOTCH1 with its ligand is cleaved to produce NEXT1\"", "Reactome:R-HSA-193679 \"alpha-secretase cleaves the p75NTR extracellular domain\"", "Reactome:R-HSA-2022368 \"MME:Zn2+ hydrolyses AGT(34-42)\"", "Reactome:R-HSA-2022393 \"ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)\"", "Reactome:R-HSA-2022396 \"MME:Zn2+ hydrolyses AGT(34-43)\"", "Reactome:R-HSA-2022399 \"ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)\"", "Reactome:R-HSA-2220944 \"ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants\"", "Reactome:R-HSA-2220976 \"NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding\"", "Reactome:R-HSA-2666278 \"NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1\"", "Reactome:R-HSA-2730752 \"NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding\"", "Reactome:R-HSA-3928660 \"ADAM10 cleaves EFNAs\"", "Reactome:R-HSA-5211340 \"Anthrax lef cleaves target cell MAP2K1 (MEK1)\"", "Reactome:R-HSA-5211356 \"Anthrax lef cleaves target cell MAP2K2 (MEK2)\"", "Reactome:R-HSA-5211387 \"Anthrax lef cleaves target cell MAP2K7 (MEK7)\"", "Reactome:R-HSA-5211391 \"Anthrax lef cleaves target cell MAP2K4 (MEK4)\"", "Reactome:R-HSA-5211400 \"Anthrax lef cleaves target cell MAP2K3 (MEK3)\"", "Reactome:R-HSA-5211405 \"Anthrax lef cleaves target cell MAP2K6 (MEK6)\"", "Reactome:R-HSA-8986181 \"PITRM1 proteolyzes mitochondrial targeting peptides (presequences)\"", "Reactome:R-HSA-9013284 \"NOTCH3-ligand complex is cleaved to produce NEXT3\"", "Reactome:R-HSA-9604264 \"ADAM10 cleaves NOTCH4\"", "Reactome:R-HSA-9662837 \"p-S,T-ADAM17(215-827):Zn2+ cleaves CD163\"" ] } } }, { "id": "GO:0008417", "name": "fucosyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9033949 \"FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC\"", "Reactome:R-HSA-9846332 \"FUT1,2 transfer fucose to gangliosides\"" ], "previous": [ "Reactome:R-HSA-9033949 \"FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC\"" ] } } }, { "id": "GO:0008425", "name": "2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.201", "Reactome:R-HSA-2162188 \"MDMQ10H2 is methylated to DMQ10H2 by COQ5\"", "RHEA:28286" ], "previous": "N/A" } } }, { "id": "GO:0008469", "name": "histone arginine N-methyltransferase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-5205799 \"CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)\"", "Reactome:R-HSA-5205861 \"COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)\"", "Reactome:R-HSA-5216234 \"PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)\"", "Reactome:R-HSA-5661117 \"CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3\"", "Reactome:R-HSA-8936584 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter\"", "Reactome:R-HSA-8936608 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter\"", "Reactome:R-HSA-8937022 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter\"", "Reactome:R-HSA-8937113 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter\"" ] } } }, { "id": "GO:0008481", "name": "sphinganine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.91", "MetaCyc:SPHINGANINE-KINASE-RXN", "RHEA:15465" ], "previous": [ "EC:2.7.1.91", "MetaCyc:SPHINGANINE-KINASE-RXN", "Reactome:R-HSA-428214 \"sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP\"", "RHEA:15465" ] } } }, { "id": "GO:0008489", "name": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9851347 \"B4GALT5/6 transfer Gal to GlcCer\"" ], "previous": "N/A" } } }, { "id": "GO:0008499", "name": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-914010 \"Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein\"", "Reactome:R-HSA-9603989 \"B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain\"", "Reactome:R-HSA-9845516 \"B3GALT4 transfers Gal to gangliosides\"" ], "previous": [ "Reactome:R-HSA-914010 \"Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein\"", "Reactome:R-HSA-9603989 \"B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain\"" ] } } }, { "id": "GO:0008659", "name": "(3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "xrefs": { "current": [ "RHEA:41892" ], "previous": [ "EC:4.2.1.59", "RHEA:41892" ] } } }, { "id": "GO:0008693", "name": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "changes": { "xrefs": { "current": [ "MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN", "RHEA:41860" ], "previous": [ "RHEA:41860" ] } } }, { "id": "GO:0008942", "name": "nitrite reductase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377", "RHEA:24632" ], "previous": [ "EC:1.7.1.4", "KEGG_REACTION:R00787", "KEGG_REACTION:R00789", "MetaCyc:RXN0-6377" ] } } }, { "id": "GO:0009982", "name": "pseudouridine synthase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6782381 \"PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs\"", "Reactome:R-HSA-6786583 \"PUS7 transforms uridine to pseudouridine in tRNAs\"", "Reactome:R-HSA-6787566 \"PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)\"", "Reactome:R-HSA-6790905 \"Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA\"", "Reactome:R-HSA-8870289 \"PUS3 transforms uridine-39 to pseudouridine-39 in tRNA\"", "RHEA:48348" ], "previous": [ "Reactome:R-HSA-6782381 \"PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs\"", "Reactome:R-HSA-6786583 \"PUS7 transforms uridine to pseudouridine in tRNAs\"", "Reactome:R-HSA-6787566 \"PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)\"", "Reactome:R-HSA-6790905 \"Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA\"", "Reactome:R-HSA-8870289 \"PUS3 transforms uridine-39 to pseudouridine-39 in tRNA\"" ] } } }, { "id": "GO:0010420", "name": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.114", "MetaCyc:RXN-9281", "Reactome:R-HSA-2162193 \"DHDB is methylated to MHDB by COQ3\"", "RHEA:44452" ], "previous": [ "EC:2.1.1.114", "MetaCyc:RXN-9281", "RHEA:44452" ] } } }, { "id": "GO:0010857", "name": "calcium-dependent protein kinase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-8986937 \"MECP2 is phosphorylated at T308\"", "Reactome:R-HSA-9005561 \"Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308\"" ] } } }, { "id": "GO:0010945", "name": "coenzyme A diphosphatase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-10811", "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"", "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"", "Reactome:R-HSA-9837354 \"NUDT8 hydrolyzes CoA-SH to PPANT\"", "RHEA:50044" ], "previous": [ "MetaCyc:RXN-10811", "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"", "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"", "RHEA:50044" ] } } }, { "id": "GO:0015078", "name": "proton transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1222516 \"Intraphagosomal pH is lowered to 5 by V-ATPase\"", "Reactome:R-HSA-164834 \"Enzyme-bound ATP is released\"", "Reactome:R-HSA-168313 \"Virion-associated M2 protein mediated ion infusion\"", "Reactome:R-HSA-170026 \"Protons are translocated from the intermembrane space to the matrix\"", "Reactome:R-HSA-74723 \"Endosome acidification\"", "Reactome:R-HSA-917841 \"Acidification of Tf:TfR1 containing endosome\"" ], "previous": [ "Reactome:R-HSA-1222516 \"Intraphagosomal pH is lowered to 5 by V-ATPase\"", "Reactome:R-HSA-164834 \"Enzyme-bound ATP is released\"", "Reactome:R-HSA-170026 \"Protons are translocated from the intermembrane space to the matrix\"", "Reactome:R-HSA-74723 \"Endosome acidification\"", "Reactome:R-HSA-917841 \"Acidification of Tf:TfR1 containing endosome\"" ] } } }, { "id": "GO:0015228", "name": "coenzyme A transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-199216 \"SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix\"", "Reactome:R-HSA-9837333 \"SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP\"" ], "previous": "N/A" } } }, { "id": "GO:0015291", "name": "secondary active transmembrane transporter activity", "changes": { "xrefs": { "current": [ "TC:2.A" ], "previous": [ "Reactome:R-HSA-199216 \"SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix\"", "TC:2.A" ] } } }, { "id": "GO:0016289", "name": "acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.1.2.10", "KEGG_REACTION:R00521", "MetaCyc:FORMYL-COA-HYDROLASE-RXN", "Reactome:R-HSA-193385 \"Hydrolysis of choloyl-CoA to cholate and CoASH\"", "RHEA:19741" ], "previous": [ "Reactome:R-HSA-193385 \"Hydrolysis of choloyl-CoA to cholate and CoASH\"" ] } } }, { "id": "GO:0016509", "name": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.211", "MetaCyc:1.1.1.211-RXN", "RHEA:52656" ], "previous": [ "EC:1.1.1.211", "MetaCyc:1.1.1.211-RXN", "Reactome:R-HSA-548818 \"HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA\"", "RHEA:52656" ] } } }, { "id": "GO:0016791", "name": "phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.-", "Reactome:R-HSA-4419986 \"Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL\"", "Reactome:R-HSA-9636457 \"SapM dephosphorylates PI3P\"", "Reactome:R-HSA-9837419 \"PANK4 hydrolyzes PPANT to pantetheine\"" ], "previous": [ "EC:3.1.3.-", "Reactome:R-HSA-4419986 \"Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL\"", "Reactome:R-HSA-9636457 \"SapM dephosphorylates PI3P\"" ] } } }, { "id": "GO:0017040", "name": "N-acylsphingosine amidohydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"ASAH2 hydrolyzes ceramide (plasma membrane)\"", "Reactome:R-HSA-1606602 \"ASAH1 hydrolyzes ceramide\"", "Reactome:R-HSA-428205 \"ACER2 hydrolyzes ceramide (Golgi)\"", "Reactome:R-HSA-428231 \"ACER1 hydrolyzes ceramide (endoplasmic reticulum)\"", "RHEA:20856" ], "previous": [ "EC:3.5.1.23", "MetaCyc:CERAMIDASE-RXN", "Reactome:R-HSA-1606583 \"Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)\"", "Reactome:R-HSA-1606602 \"Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)\"", "Reactome:R-HSA-428205 \"ceramide + H2O => stearate + sphingosine [Golgi]\"", "Reactome:R-HSA-428231 \"ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]\"", "RHEA:20856" ] } } }, { "id": "GO:0017050", "name": "D-erythro-sphingosine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.91", "MetaCyc:RXN3DJ-11417", "Reactome:R-HSA-5218845 \"p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate\"", "Reactome:R-HSA-9625814 \"SPHK1 phosphorylates sphingosine in response to E2 stimulation\"", "RHEA:35847" ], "previous": [ "EC:2.7.1.91", "MetaCyc:RXN3DJ-11417", "Reactome:R-HSA-428273 \"SPHK1 phosphorylates SPG to S1P\"", "Reactome:R-HSA-5218845 \"p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate\"", "Reactome:R-HSA-9625814 \"SPHK1 phosphorylates sphingosine in response to E2 stimulation\"", "Reactome:R-HSA-9695949 \"SPHK2 phosphorylates SPG to S1P\"", "RHEA:35847" ] } } }, { "id": "GO:0017089", "name": "glycolipid transfer activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5340320 \"GLTP transports GSL from plasma membrane to ER membrane\"", "Reactome:R-HSA-9697077 \"Rv1410c transports lprG:LM,LAM from cytosol to the cell wall\"", "Reactome:R-HSA-9844955 \"CLN3 transports GalCer to plasma membrane\"", "Reactome:R-HSA-9845055 \"PLEKHA8 catalyzes transport of GlcCer to plasma membrane\"" ], "previous": [ "Reactome:R-HSA-5340320 \"GLTP transports GSL from plasma membrane to ER membrane\"", "Reactome:R-HSA-9697077 \"Rv1410c transports lprG:LM,LAM from cytosol to the cell wall\"" ] } } }, { "id": "GO:0018638", "name": "toluene 4-monooxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.13.236", "RHEA:41380", "UM-BBD_enzymeID:e0225" ], "previous": [ "EC:1.14.13.-", "UM-BBD_enzymeID:e0225" ] } } }, { "id": "GO:0018641", "name": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "changes": { "xrefs": { "current": [ "UM-BBD_reactionID:r0048" ], "previous": [ "EC:1.14.13.-", "UM-BBD_reactionID:r0048" ] } } }, { "id": "GO:0018814", "name": "phenylacetaldoxime dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.8.1.4", "KEGG_REACTION:R07638", "MetaCyc:4.99.1.7-RXN", "RHEA:20069", "UM-BBD_reactionID:r0697" ], "previous": [ "EC:4.99.1.7", "KEGG_REACTION:R07638", "MetaCyc:4.99.1.7-RXN", "RHEA:20069", "UM-BBD_reactionID:r0697" ] } } }, { "id": "GO:0019171", "name": "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.59", "MetaCyc:4.2.1.59-RXN", "RHEA:13097" ], "previous": [ "EC:4.2.1.59", "MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN", "RHEA:13097" ] } } }, { "id": "GO:0019706", "name": "protein-cysteine S-palmitoyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.225", "Reactome:R-HSA-5682084 \"ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer\"", "Reactome:R-HSA-9021072 \"ZDHHC7, ZDHHC21 palmitoylate ESR1\"", "Reactome:R-HSA-9647982 \"S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated\"", "Reactome:R-HSA-9694341 \"Spike protein gets palmitoylated\"", "Reactome:R-HSA-9829047 \"F0 is palmitoylated\"", "Reactome:R-HSA-9830875 \"G is palmitoylated\"", "RHEA:36683" ], "previous": [ "EC:2.3.1.225", "Reactome:R-HSA-5682084 \"ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer\"", "Reactome:R-HSA-9021072 \"ZDHHC7, ZDHHC21 palmitoylate ESR1\"", "Reactome:R-HSA-9647982 \"S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated\"", "Reactome:R-HSA-9694341 \"Spike protein gets palmitoylated\"", "RHEA:36683" ] } } }, { "id": "GO:0022857", "name": "transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1236947 \"Egress of internalized antigen to the cytosol via sec61\"", "Reactome:R-HSA-429036 \"SLC2A9 transports Fru, Glc, urate\"", "Reactome:R-HSA-434650 \"MATEs mediate extrusion of xenobiotics\"", "Reactome:R-HSA-5638209 \"Defective SLC2A9 does not transport Fru, Glc, urate\"", "Reactome:R-HSA-5671707 \"Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA\"", "Reactome:R-HSA-6784434 \"An unknown carrier transports cytosolic glyoxylate to the peroxisome\"", "Reactome:R-HSA-6784436 \"An unknown carrier transports mitochondrial glyoxylate to the cytosol\"" ], "previous": [ "Reactome:R-HSA-1236947 \"Egress of internalized antigen to the cytosol via sec61\"", "Reactome:R-HSA-429036 \"SLC2A9 transports Fru, Glc, urate\"", "Reactome:R-HSA-5638209 \"Defective SLC2A9 does not transport Fru, Glc, urate\"", "Reactome:R-HSA-5671707 \"Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA\"", "Reactome:R-HSA-6784434 \"An unknown carrier transports cytosolic glyoxylate to the peroxisome\"", "Reactome:R-HSA-6784436 \"An unknown carrier transports mitochondrial glyoxylate to the cytosol\"" ] } } }, { "id": "GO:0030290", "name": "sphingolipid activator protein activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1605717 \"GM2A binds and mobilizes ligands\"", "Reactome:R-HSA-9840470 \"PSAP(195-273) dimer:PE binds and mobilizes ligands\"" ], "previous": [ "Reactome:R-HSA-1605717 \"Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage\"" ] } } }, { "id": "GO:0030596", "name": "alpha-L-rhamnosidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.40", "KEGG_REACTION:R02436", "MetaCyc:3.2.1.40-RXN", "RHEA:17465" ], "previous": [ "EC:3.2.1.40", "MetaCyc:3.2.1.40-RXN" ] } } }, { "id": "GO:0031071", "name": "cysteine desulfurase activity", "changes": { "xrefs": { "current": [ "EC:2.8.1.7", "Reactome:R-HSA-1362408 \"FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster\"", "Reactome:R-HSA-947514 \"PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3\"", "RHEA:43892" ], "previous": [ "EC:2.8.1.7", "Reactome:R-HSA-1362408 \"FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster\"", "Reactome:R-HSA-947514 \"PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3\"", "RHEA:43892" ] } } }, { "id": "GO:0031544", "name": "peptidyl-proline 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9630769 \"OGFOD1:Fe2+ hydroxylates a proline residue of RPS23\"" ], "previous": "N/A" } } }, { "id": "GO:0031955", "name": "short-chain fatty acid-CoA ligase activity", "changes": { "xrefs": { "current": [ "RHEA:52860" ], "previous": "N/A" } } }, { "id": "GO:0031957", "name": "very long-chain fatty acid-CoA ligase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5695957 \"ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA\"", "Reactome:R-HSA-5696007 \"ACSF3 ligates CoA-SH to VLCFA\"", "Reactome:R-HSA-8875077 \"SLC27A3 ligates CoA-SH to VLCFA\"", "RHEA:54536" ], "previous": [ "Reactome:R-HSA-5695957 \"ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA\"", "Reactome:R-HSA-5696007 \"ACSF3 ligates CoA-SH to VLCFA\"", "Reactome:R-HSA-8875077 \"SLC27A3 ligates CoA-SH to VLCFA\"" ] } } }, { "id": "GO:0032453", "name": "histone H3K4 demethylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9822461 \"KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3)\"", "Reactome:R-HSA-9822467 \"KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)\"" ], "previous": "N/A" } } }, { "id": "GO:0033188", "name": "sphingomyelin synthase activity", "changes": { "xrefs": { "current": [ "EC:2.7.8.27", "KEGG_REACTION:R08969", "MetaCyc:2.7.8.27-RXN", "Reactome:R-HSA-429786 \"SGMS2 transfers phosphocholine onto ceramide\"", "Reactome:R-HSA-429798 \"SGMS1 transfers phosphocholine onto ceramide\"", "RHEA:18765" ], "previous": [ "EC:2.7.8.27", "KEGG_REACTION:R08969", "MetaCyc:2.7.8.27-RXN", "Reactome:R-HSA-429786 \"phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]\"", "Reactome:R-HSA-429798 \"phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]\"", "RHEA:18765" ] } } }, { "id": "GO:0034013", "name": "aliphatic aldoxime dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.8.1.2", "MetaCyc:4.99.1.5-RXN", "RHEA:11316" ], "previous": [ "EC:4.99.1.5", "MetaCyc:4.99.1.5-RXN", "RHEA:11316" ] } } }, { "id": "GO:0034458", "name": "3'-5' RNA helicase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9836927 \"SUPV3L1 unwinds double-stranded mitochondiral RNA\"" ], "previous": "N/A" } } }, { "id": "GO:0034604", "name": "pyruvate dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.2.1.104", "KEGG_REACTION:R00209", "MetaCyc:PYRUVDEH-RXN", "RHEA:28042" ], "previous": [ "KEGG_REACTION:R00209", "MetaCyc:PYRUVDEH-RXN", "RHEA:28042" ] } } }, { "id": "GO:0035516", "name": "broad specificity oxidative DNA demethylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.33", "MetaCyc:RXN-12353", "Reactome:R-HSA-112118 \"Oxidative demethylation of 1-meA damaged DNA by ALKBH2\"", "Reactome:R-HSA-112123 \"Oxidative demethylation of 1-meA damaged DNA By ALKBH3\"", "RHEA:30299" ], "previous": [ "EC:1.14.11.33", "MetaCyc:RXN-12353", "RHEA:30299" ] } } }, { "id": "GO:0036139", "name": "peptidyl-histidine dioxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9630967 \"RIOX2Fe2+ hydroxylates a histidine residue of RPL27A\"", "Reactome:R-HSA-9630993 \"RIOX1:Fe2+ hydroxylates a histidine residue of RPL8\"" ], "previous": "N/A" } } }, { "id": "GO:0042054", "name": "histone methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5205861 \"COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)\"", "Reactome:R-HSA-5216234 \"PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)\"", "Reactome:R-HSA-9822583 \"METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)\"" ], "previous": "N/A" } } }, { "id": "GO:0042284", "name": "sphingolipid delta-4 desaturase activity", "changes": { "xrefs": { "current": [ "EC:1.14.19.17", "Reactome:R-HSA-428259 \"DEGS1 dehydrogenates dihydroceramide\"", "RHEA:46544" ], "previous": [ "EC:1.14.19.17", "Reactome:R-HSA-428259 \"dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O\"", "RHEA:46544" ] } } }, { "id": "GO:0042392", "name": "sphingosine-1-phosphate phosphatase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN3DJ-25", "Reactome:R-HSA-428690 \"PLPP1 dephosphorylates extracellular sphingosine-1-phosphate\"", "Reactome:R-HSA-428696 \"PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate\"", "RHEA:27518" ], "previous": [ "MetaCyc:RXN3DJ-25", "Reactome:R-HSA-428690 \"sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]\"", "Reactome:R-HSA-428696 \"sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]\"", "Reactome:R-HSA-428701 \"sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]\"", "RHEA:27518" ] } } }, { "id": "GO:0042910", "name": "xenobiotic transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5625574 \"Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+\"", "Reactome:R-HSA-597628 \"SLC22A18 exchanges extracellular organic cations for cytosolic H+\"" ], "previous": "N/A" } } }, { "id": "GO:0045145", "name": "single-stranded DNA 5'-3' DNA exonuclease activity", "changes": { "xrefs": { "current": [ "EC:3.1.11.4" ], "previous": "N/A" } } }, { "id": "GO:0046624", "name": "sphingolipid transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9695890 \"SPNS2,MFSD2B transport S1P from cytosol to extracellular region\"", "Reactome:R-HSA-9843721 \"ABCC1,ABCG2 transport C18-S1P to extracellular region\"" ], "previous": [ "Reactome:R-HSA-9695890 \"SPNS2 transports S1P from cytosol to extracellular region\"" ] } } }, { "id": "GO:0047101", "name": "branched-chain alpha-keto acid dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.2.1.25", "MetaCyc:1.2.1.25-RXN" ], "previous": [ "EC:1.2.1.25", "MetaCyc:1.2.1.25-RXN", "RHEA:13997" ] } } }, { "id": "GO:0047256", "name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.206", "MetaCyc:2.4.1.206-RXN", "Reactome:R-HSA-9846501 \"B3GNT5 transfers GlcNAc to LacCer\"", "RHEA:13905" ], "previous": [ "EC:2.4.1.206", "MetaCyc:2.4.1.206-RXN", "RHEA:13905" ] } } }, { "id": "GO:0047273", "name": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.79", "MetaCyc:2.4.1.79-RXN", "Reactome:R-HSA-8878914 \"B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer\"", "RHEA:22252" ], "previous": [ "EC:2.4.1.79", "MetaCyc:2.4.1.79-RXN", "Reactome:R-HSA-8878914 \"B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer\"", "RHEA:22252" ] } } }, { "id": "GO:0047450", "name": "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R04428", "RHEA:41808" ], "previous": [ "KEGG_REACTION:R04428", "MetaCyc:4.2.1.58-RXN", "RHEA:41808" ] } } }, { "id": "GO:0047560", "name": "3-dehydrosphinganine reductase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.102", "KEGG_REACTION:R02978", "MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN", "Reactome:R-HSA-428123 \"KDSR reduces 3-ketosphingoid\"", "RHEA:22640" ], "previous": [ "EC:1.1.1.102", "KEGG_REACTION:R02978", "MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN", "Reactome:R-HSA-428123 \"3-ketosphinganine + NADPH + H+ => sphinganine + NADP+\"", "RHEA:22640" ] } } }, { "id": "GO:0047617", "name": "fatty acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.1.2.20", "EC:3.1.2.3", "MetaCyc:ACYL-COA-HYDROLASE-RXN", "Reactome:R-HSA-5690042 \"Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA\"", "Reactome:R-HSA-5690043 \"Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA\"", "Reactome:R-HSA-5690066 \"ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA\"", "RHEA:16781" ], "previous": [ "EC:3.1.2.20", "MetaCyc:ACYL-COA-HYDROLASE-RXN", "Reactome:R-HSA-5690042 \"Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA\"", "Reactome:R-HSA-5690043 \"Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA\"", "Reactome:R-HSA-5690066 \"ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA\"", "RHEA:16781" ] } } }, { "id": "GO:0047720", "name": "indoleacetaldoxime dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.8.1.3", "KEGG_REACTION:R04093", "MetaCyc:RXN-19838", "RHEA:23156" ], "previous": [ "EC:4.99.1.6", "KEGG_REACTION:R04093", "MetaCyc:RXN-19838", "RHEA:23156" ] } } }, { "id": "GO:0047826", "name": "D-lysine 5,6-aminomutase activity", "changes": { "xrefs": { "current": [ "EC:5.4.3.4", "KEGG_REACTION:R02852", "MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN", "RHEA:18241" ], "previous": [ "EC:5.4.3.4", "KEGG_REACTION:R02852", "MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN", "RHEA:18241" ] } } }, { "id": "GO:0047904", "name": "fructose 5-dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.1.5.14", "KEGG_REACTION:R00873", "MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN", "RHEA:22304" ], "previous": [ "EC:1.1.99.11", "KEGG_REACTION:R00873", "MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN", "RHEA:22304" ] } } }, { "id": "GO:0050135", "name": "NADP+ nucleosidase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9637699 \"CpnT hydrolyses NAD+\"", "RHEA:19849" ], "previous": [ "EC:3.2.2.6", "MetaCyc:NADNUCLEOSID-RXN" ] } } }, { "id": "GO:0050265", "name": "RNA uridylyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.7.7.52", "MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN", "Reactome:R-HSA-8941312 \"TUT4,TUT7 oligouridylate mRNA\"", "RHEA:14785" ], "previous": [ "EC:2.7.7.52", "MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN", "Reactome:R-HSA-8941312 \"ZCCHC6, ZCCHC11 are mRNA uridyltransferases\"", "RHEA:14785" ] } } }, { "id": "GO:0050291", "name": "sphingosine N-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.24", "MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-428185 \"Ceramide synthases transfer acyl-CoA onto sphingoid\"", "RHEA:23768" ], "previous": [ "EC:2.3.1.24", "MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-428185 \"sphinganine + stearyl-CoA => dihydroceramide + CoASH\"", "RHEA:23768" ] } } }, { "id": "GO:0050501", "name": "hyaluronan synthase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.212", "MetaCyc:2.4.1.212-RXN", "Reactome:R-HSA-2160851 \"HAS1,2,3 mediate the polymerization of HA\"", "RHEA:12528" ], "previous": [ "EC:2.4.1.212", "MetaCyc:2.4.1.212-RXN", "Reactome:R-HSA-2160851 \"HAS1,2,3 mediate the polymerisation of HA\"", "RHEA:12528" ] } } }, { "id": "GO:0050512", "name": "lactosylceramide 4-alpha-galactosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.228", "MetaCyc:2.4.1.228-RXN", "Reactome:R-HSA-9846477 \"A4GALT transfers galactose to LacCer\"", "RHEA:11924" ], "previous": [ "EC:2.4.1.228", "MetaCyc:2.4.1.228-RXN", "RHEA:11924" ] } } }, { "id": "GO:0051392", "name": "tRNA N-acetyltransferase activity", "changes": { "xrefs": { "current": [ "RHEA:53876" ], "previous": "N/A" } } }, { "id": "GO:0051908", "name": "double-stranded DNA 5'-3' DNA exonuclease activity", "changes": { "xrefs": { "current": [ "EC:3.1.11.3" ], "previous": "N/A" } } }, { "id": "GO:0052642", "name": "lysophosphatidic acid phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.106", "MetaCyc:RXNQT-4375", "Reactome:R-HSA-8878654 \"ACP6 hydrolyses MYS-LPA\"", "RHEA:33155" ], "previous": [ "Reactome:R-HSA-8878654 \"ACP6 hydrolyses MYS-LPA\"" ] } } }, { "id": "GO:0052742", "name": "phosphatidylinositol kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1675773 \"PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0052815", "name": "medium-chain fatty acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "MetaCyc:3.1.2.19-RXN", "RHEA:68184" ], "previous": "N/A" } } }, { "id": "GO:0052816", "name": "long-chain fatty acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "RHEA:67680" ], "previous": "N/A" } } }, { "id": "GO:0052817", "name": "very long-chain fatty acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "RHEA:67072" ], "previous": "N/A" } } }, { "id": "GO:0052905", "name": "tRNA (guanosine(9)-N1)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.221", "MetaCyc:RXN-12459", "Reactome:R-HSA-6786621 \"TRMT10A methylates guanosine-9 in tRNA\"", "Reactome:R-HSA-6787591 \"TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9\"", "RHEA:43156" ], "previous": [ "EC:2.1.1.221", "MetaCyc:RXN-12459", "RHEA:43156" ] } } }, { "id": "GO:0052906", "name": "tRNA (guanine(37)-N1)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.228", "MetaCyc:RXN-12458", "Reactome:R-HSA-6782859 \"TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)\"", "RHEA:36899" ], "previous": [ "EC:2.1.1.228", "MetaCyc:RXN-12458", "RHEA:36899" ] } } }, { "id": "GO:0061522", "name": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.2.28", "RHEA:26309" ], "previous": "N/A" } } }, { "id": "GO:0061542", "name": "3-demethylubiquinol-n 3-O-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.64", "Reactome:R-HSA-2162186 \"DeMQ10H2 is methylated to Q10H2 by COQ3\"", "RHEA:44380" ], "previous": [ "EC:2.1.1.64", "RHEA:44380" ] } } }, { "id": "GO:0061630", "name": "ubiquitin protein ligase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1225956 \"Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL\"", "Reactome:R-HSA-1504190 \"DVL is ubiquitinated by CUL3:KLHL12:RBX1\"", "Reactome:R-HSA-183036 \"Ubiquitination of stimulated EGFR (CBL:GRB2)\"", "Reactome:R-HSA-201445 \"Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8\"", "Reactome:R-HSA-3322429 \"XIAP monoubiquinates TLE\"", "Reactome:R-HSA-3640861 \"RNF146 ubiquitinates ADP-ribosylated AXIN\"", "Reactome:R-HSA-4608852 \"SMURF1/2 ubiquitinates PRICKLE1\"", "Reactome:R-HSA-4641129 \"AXIN is ubiquitinated by SMURF2\"", "Reactome:R-HSA-4641159 \"DVL1 is ubiquitinated by HECW1\"", "Reactome:R-HSA-4641246 \"ZNRF3 autoubiquitinates to promote its internalization\"", "Reactome:R-HSA-4641253 \"ZNRF3 ubiquitinates FZD to promote its downregulation\"", "Reactome:R-HSA-5246693 \"APC is K63-polyubiquitinated\"", "Reactome:R-HSA-5610737 \"NUMB:ITCH bind and ubiquitnate GLI1\"", "Reactome:R-HSA-5632648 \"SMURF1/2 ubiquitinates PTCH1\"", "Reactome:R-HSA-5635856 \"SPOP:CUL3:RBX1 ubiquitinates GLI2,3\"", "Reactome:R-HSA-5635864 \"NUMB:ITCH ubiquitinates GLI1\"", "Reactome:R-HSA-5654672 \"CBL ubiquitinates FRS2 and FGFR1\"", "Reactome:R-HSA-5654677 \"CBL ubiquitinates FRS2 and FGFR2\"", "Reactome:R-HSA-5654679 \"CBL ubiquitinates FRS2 and FGFR3\"", "Reactome:R-HSA-5654684 \"CBL ubiquitinates FRS2 and FGFR4\"", "Reactome:R-HSA-5658424 \"KBTBD7:CUL3:RBX1 ubiquitinates NF1\"", "Reactome:R-HSA-5674022 \"BRAP autoubiquitinates\"", "Reactome:R-HSA-5682858 \"RNF8 and RNF168 ubiquitinate H2AFX\"", "Reactome:R-HSA-5684071 \"RNF4 ubiquitinates MDC1\"", "Reactome:R-HSA-5687081 \"MAPK6 is ubiquitinated at the N-terminal\"", "Reactome:R-HSA-5689111 \"PARK2 autoubiquitinates\"", "Reactome:R-HSA-5690827 \"TNFAIP3 (A20) ubiquitinates RIPK1\"", "Reactome:R-HSA-6781867 \"ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II\"", "Reactome:R-HSA-6782943 \"UV-DDB ubiquitinates XPC\"", "Reactome:R-HSA-6785361 \"Monoubiquitination of FANCD2:FANCI\"", "Reactome:R-HSA-6790487 \"RNF111 ubiquitinates SUMOylated XPC\"", "Reactome:R-HSA-6798373 \"MDM2 ubiquitinates DYRK2\"", "Reactome:R-HSA-6804253 \"MDM2 ubiquitinates JMY\"", "Reactome:R-HSA-6804441 \"RNF34 or RFFL ubiquitinates phosphorylated TP53\"", "Reactome:R-HSA-6804724 \"MDM2 ubiquitinates phosphorylated MDM4\"", "Reactome:R-HSA-6804879 \"MDM2 ubiquitinates TP53\"", "Reactome:R-HSA-6804942 \"MDM2 homodimers auto-ubiquitinate\"", "Reactome:R-HSA-6807106 \"PTEN undergoes monoubiquitination\"", "Reactome:R-HSA-6807134 \"NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN\"", "Reactome:R-HSA-68946 \"Phosphorylated Orc1 is ubiquitinated while still associated with chromatin\"", "Reactome:R-HSA-69015 \"Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex\"", "Reactome:R-HSA-8848829 \"CBL autoubiquitinates\"", "Reactome:R-HSA-8851011 \"TRIM27 polyubiquitinates PTEN\"", "Reactome:R-HSA-8854041 \"SCF-FBXL7 ubiquitinates AURKA\"", "Reactome:R-HSA-8854051 \"SCF-FBXL18 ubiquitinates FBXL7\"", "Reactome:R-HSA-8854628 \"MYLIP dimer ubiquitinates VLDLR on Lys-839\"", "Reactome:R-HSA-8866546 \"RNF5 and RNF185 ubiquitinate misfolded CFTR\"", "Reactome:R-HSA-8866856 \"RNF5 and RNF185 ubiquitinate CFTR F508del\"", "Reactome:R-HSA-8867288 \"OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5\"", "Reactome:R-HSA-8875183 \"CBL monoubiquitinates activated MET\"", "Reactome:R-HSA-8875431 \"LRIG1 undergoes ubiquitination\"", "Reactome:R-HSA-8876258 \"CBL monoubiquitinates InlB-bound MET\"", "Reactome:R-HSA-8877003 \"CBLL1 ubiqutinates the InlA-bound CDH1 complex\"", "Reactome:R-HSA-8938773 \"RNF144A polyubiquitinates PRKDC\"", "Reactome:R-HSA-8938815 \"RNF152 polyubiquitinates RRAGA\"", "Reactome:R-HSA-8939335 \"RNF181 polyubiquinates BCL10\"", "Reactome:R-HSA-8939706 \"SCF(SKP2) polyubiquitinates RUNX2\"", "Reactome:R-HSA-8942101 \"RNF20:RNF40 monoubiquitinates Histone H2B\"", "Reactome:R-HSA-8943003 \"SHPRH polyubiquitinates monoubiquitinated PCNA\"", "Reactome:R-HSA-8943040 \"HLTF polyubiquitinates monoubiquitinated PCNA\"", "Reactome:R-HSA-8943080 \"TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11\"", "Reactome:R-HSA-8948775 \"MKRN1 polyubiquitinates PTEN\"", "Reactome:R-HSA-8948832 \"RNF146 polyubiquitinates PARylated PTEN\"", "Reactome:R-HSA-8952382 \"MDM2 polyubiquitinates RUNX3\"", "Reactome:R-HSA-8952419 \"SMURFs ubiquitinate RUNX3\"", "Reactome:R-HSA-8953946 \"PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11\"", "Reactome:R-HSA-8956026 \"CUL9:RBX1 ubiquitinates BIRC5\"", "Reactome:R-HSA-8956684 \"ITCH polyubiquitinates TP73\"", "Reactome:R-HSA-9008076 \"WWP1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9008479 \"FBXW7 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9009308 \"STUB1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9009403 \"SMURF1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9011300 \"ZSWIM8 ubiquitinates ROBO3.1\"", "Reactome:R-HSA-9021523 \"WWP2 ubiquitinates NOTCH3\"", "Reactome:R-HSA-9033485 \"PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11\"", "Reactome:R-HSA-934604 \"Phosphorylated SPRY2 is ubiquitinated by CBL\"", "Reactome:R-HSA-936462 \"PIN1 mediated IRF3 degradation\"", "Reactome:R-HSA-936475 \"Negative regulation of DDX58/IFIH1 signaling by RNF216\"", "Reactome:R-HSA-9604629 \"FBXW7 promotes ubiquitination of p-NICD4\"", "Reactome:R-HSA-9685195 \"SARS-CoV-1 9b recruits ITCH to MAVS\"", "Reactome:R-HSA-9686920 \"PELI1 ubiquitinates RIPK3 at K363\"", "Reactome:R-HSA-9686969 \"APC/C:Cdh1 polyubiquitinates SKP2\"", "Reactome:R-HSA-9705738 \"SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7\"", "Reactome:R-HSA-9706354 \"Ubiquitination of FLT3\"", "Reactome:R-HSA-9706356 \"CBL mutants don't ubiquitinate FLT3\"", "Reactome:R-HSA-9708517 \"FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))\"", "Reactome:R-HSA-9733316 \"p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL\"", "Reactome:R-HSA-9755304 \"MUL1 ubiquitinates UBXN7\"", "Reactome:R-HSA-9755505 \"KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2\"", "Reactome:R-HSA-9759154 \"TRIM21 ubiquitinates SQSTM1\"", "Reactome:R-HSA-9759172 \"KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer\"", "Reactome:R-HSA-9762091 \"NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1\"", "Reactome:R-HSA-9766645 \"CUL3:RBX1 ubiquitinates KEAP1\"", "Reactome:R-HSA-990526 \"Recruitment of ITCH and K48 ubiquitination of MAVS\"" ], "previous": [ "Reactome:R-HSA-1225956 \"Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL\"", "Reactome:R-HSA-1504190 \"DVL is ubiquitinated by CUL3:KLHL12:RBX1\"", "Reactome:R-HSA-201445 \"Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8\"", "Reactome:R-HSA-3322429 \"XIAP monoubiquinates TLE\"", "Reactome:R-HSA-3640861 \"RNF146 ubiquitinates ADP-ribosylated AXIN\"", "Reactome:R-HSA-4608852 \"SMURF1/2 ubiquitinates PRICKLE1\"", "Reactome:R-HSA-4641129 \"AXIN is ubiquitinated by SMURF2\"", "Reactome:R-HSA-4641159 \"DVL1 is ubiquitinated by HECW1\"", "Reactome:R-HSA-4641246 \"ZNRF3 autoubiquitinates to promote its internalization\"", "Reactome:R-HSA-4641253 \"ZNRF3 ubiquitinates FZD to promote its downregulation\"", "Reactome:R-HSA-5246693 \"APC is K63-polyubiquitinated\"", "Reactome:R-HSA-5610737 \"NUMB:ITCH bind and ubiquitnate GLI1\"", "Reactome:R-HSA-5632648 \"SMURF1/2 ubiquitinates PTCH1\"", "Reactome:R-HSA-5635856 \"SPOP:CUL3:RBX1 ubiquitinates GLI2,3\"", "Reactome:R-HSA-5635864 \"NUMB:ITCH ubiquitinates GLI1\"", "Reactome:R-HSA-5654672 \"CBL ubiquitinates FRS2 and FGFR1\"", "Reactome:R-HSA-5654677 \"CBL ubiquitinates FRS2 and FGFR2\"", "Reactome:R-HSA-5654679 \"CBL ubiquitinates FRS2 and FGFR3\"", "Reactome:R-HSA-5654684 \"CBL ubiquitinates FRS2 and FGFR4\"", "Reactome:R-HSA-5658424 \"KBTBD7:CUL3:RBX1 ubiquitinates NF1\"", "Reactome:R-HSA-5674022 \"BRAP autoubiquitinates\"", "Reactome:R-HSA-5682858 \"RNF8 and RNF168 ubiquitinate H2AFX\"", "Reactome:R-HSA-5684071 \"RNF4 ubiquitinates MDC1\"", "Reactome:R-HSA-5687081 \"MAPK6 is ubiquitinated at the N-terminal\"", "Reactome:R-HSA-5689111 \"PARK2 autoubiquitinates\"", "Reactome:R-HSA-5690827 \"TNFAIP3 (A20) ubiquitinates RIPK1\"", "Reactome:R-HSA-6781867 \"ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II\"", "Reactome:R-HSA-6782943 \"UV-DDB ubiquitinates XPC\"", "Reactome:R-HSA-6785361 \"Monoubiquitination of FANCD2:FANCI\"", "Reactome:R-HSA-6790487 \"RNF111 ubiquitinates SUMOylated XPC\"", "Reactome:R-HSA-6798373 \"MDM2 ubiquitinates DYRK2\"", "Reactome:R-HSA-6804253 \"MDM2 ubiquitinates JMY\"", "Reactome:R-HSA-6804441 \"RNF34 or RFFL ubiquitinates phosphorylated TP53\"", "Reactome:R-HSA-6804724 \"MDM2 ubiquitinates phosphorylated MDM4\"", "Reactome:R-HSA-6804879 \"MDM2 ubiquitinates TP53\"", "Reactome:R-HSA-6804942 \"MDM2 homodimers auto-ubiquitinate\"", "Reactome:R-HSA-6807106 \"PTEN undergoes monoubiquitination\"", "Reactome:R-HSA-6807134 \"NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN\"", "Reactome:R-HSA-68946 \"Phosphorylated Orc1 is ubiquitinated while still associated with chromatin\"", "Reactome:R-HSA-69015 \"Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex\"", "Reactome:R-HSA-8848829 \"CBL autoubiquitinates\"", "Reactome:R-HSA-8851011 \"TRIM27 polyubiquitinates PTEN\"", "Reactome:R-HSA-8854041 \"SCF-FBXL7 ubiquitinates AURKA\"", "Reactome:R-HSA-8854051 \"SCF-FBXL18 ubiquitinates FBXL7\"", "Reactome:R-HSA-8854628 \"MYLIP dimer ubiquitinates VLDLR on Lys-839\"", "Reactome:R-HSA-8866546 \"RNF5 and RNF185 ubiquitinate misfolded CFTR\"", "Reactome:R-HSA-8866856 \"RNF5 and RNF185 ubiquitinate CFTR F508del\"", "Reactome:R-HSA-8867288 \"OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5\"", "Reactome:R-HSA-8875183 \"CBL monoubiquitinates activated MET\"", "Reactome:R-HSA-8875431 \"LRIG1 undergoes ubiquitination\"", "Reactome:R-HSA-8876258 \"CBL monoubiquitinates InlB-bound MET\"", "Reactome:R-HSA-8877003 \"CBLL1 ubiqutinates the InlA-bound CDH1 complex\"", "Reactome:R-HSA-8938773 \"RNF144A polyubiquitinates PRKDC\"", "Reactome:R-HSA-8938815 \"RNF152 polyubiquitinates RRAGA\"", "Reactome:R-HSA-8939335 \"RNF181 polyubiquinates BCL10\"", "Reactome:R-HSA-8939706 \"SCF(SKP2) polyubiquitinates RUNX2\"", "Reactome:R-HSA-8942101 \"RNF20:RNF40 monoubiquitinates Histone H2B\"", "Reactome:R-HSA-8943003 \"SHPRH polyubiquitinates monoubiquitinated PCNA\"", "Reactome:R-HSA-8943040 \"HLTF polyubiquitinates monoubiquitinated PCNA\"", "Reactome:R-HSA-8943080 \"TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11\"", "Reactome:R-HSA-8948775 \"MKRN1 polyubiquitinates PTEN\"", "Reactome:R-HSA-8948832 \"RNF146 polyubiquitinates PARylated PTEN\"", "Reactome:R-HSA-8952382 \"MDM2 polyubiquitinates RUNX3\"", "Reactome:R-HSA-8952419 \"SMURFs ubiquitinate RUNX3\"", "Reactome:R-HSA-8953946 \"PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11\"", "Reactome:R-HSA-8956026 \"CUL9:RBX1 ubiquitinates BIRC5\"", "Reactome:R-HSA-8956684 \"ITCH polyubiquitinates TP73\"", "Reactome:R-HSA-9008076 \"WWP1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9008479 \"FBXW7 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9009308 \"STUB1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9009403 \"SMURF1 polyubiquitinates RUNX2\"", "Reactome:R-HSA-9011300 \"ZSWIM8 ubiquitinates ROBO3.1\"", "Reactome:R-HSA-9021523 \"WWP2 ubiquitinates NOTCH3\"", "Reactome:R-HSA-9033485 \"PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11\"", "Reactome:R-HSA-934604 \"Phosphorylated SPRY2 is ubiquitinated by CBL\"", "Reactome:R-HSA-936462 \"PIN1 mediated IRF3 degradation\"", "Reactome:R-HSA-936475 \"Negative regulation of DDX58/IFIH1 signaling by RNF216\"", "Reactome:R-HSA-9604629 \"FBXW7 promotes ubiquitination of p-NICD4\"", "Reactome:R-HSA-9685195 \"SARS-CoV-1 9b recruits ITCH to MAVS\"", "Reactome:R-HSA-9686920 \"PELI1 ubiquitinates RIPK3 at K363\"", "Reactome:R-HSA-9686969 \"APC/C:Cdh1 polyubiquitinates SKP2\"", "Reactome:R-HSA-9705738 \"SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7\"", "Reactome:R-HSA-9706354 \"Ubiquitination of FLT3\"", "Reactome:R-HSA-9706356 \"CBL mutants don't ubiquitinate FLT3\"", "Reactome:R-HSA-9708517 \"FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))\"", "Reactome:R-HSA-9733316 \"p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL\"", "Reactome:R-HSA-9755304 \"MUL1 ubiquitinates UBXN7\"", "Reactome:R-HSA-9755505 \"KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2\"", "Reactome:R-HSA-9759154 \"TRIM21 ubiquitinates SQSTM1\"", "Reactome:R-HSA-9759172 \"KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer\"", "Reactome:R-HSA-9762091 \"NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1\"", "Reactome:R-HSA-9766645 \"CUL3:RBX1 ubiquitinates KEAP1\"", "Reactome:R-HSA-990526 \"Recruitment of ITCH and K48 ubiquitination of MAVS\"" ] } } }, { "id": "GO:0061665", "name": "SUMO ligase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9834809 \"SUMOylation of PKR\"" ], "previous": "N/A" } } }, { "id": "GO:0061809", "name": "NAD+ nucleotidase, cyclic ADP-ribose generating", "changes": { "xrefs": { "current": [ "EC:3.2.2.6", "MetaCyc:NADNUCLEOSID-RXN", "RHEA:16301 {xref=\"skos:broadMatch\"}" ], "previous": [ "EC:3.2.2.6", "MetaCyc:NADNUCLEOSID-RXN" ] } } }, { "id": "GO:0061995", "name": "ATP-dependent protein-DNA complex displacement activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9822115 \"NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA\"" ], "previous": "N/A" } } }, { "id": "GO:0062101", "name": "peptidyl-aspartic acid 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RESID:AA0026", "RHEA:11508" ], "previous": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "RESID:AA0026", "RHEA:11508" ] } } }, { "id": "GO:0070551", "name": "endoribonuclease activity, cleaving siRNA-paired mRNA", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9820842 \"AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote\"" ], "previous": "N/A" } } }, { "id": "GO:0070579", "name": "5-methylcytosine dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.80", "Reactome:R-HSA-5220952 \"TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine\"", "Reactome:R-HSA-5220990 \"TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine\"", "Reactome:R-HSA-5221014 \"TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine\"", "Reactome:R-HSA-9817458 \"TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3\"", "WIkipedia:DNA_demethylation" ], "previous": [ "EC:1.14.11.80", "Reactome:R-HSA-5220952 \"TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine\"", "Reactome:R-HSA-5220990 \"TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine\"", "Reactome:R-HSA-5221014 \"TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine\"" ] } } }, { "id": "GO:0070774", "name": "phytoceramidase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R06528", "MetaCyc:CERAMIDASE-YEAST-RXN", "Reactome:R-HSA-428262 \"ACER3 hydrolyzes phytoceramide\"" ], "previous": [ "KEGG_REACTION:R06528", "MetaCyc:CERAMIDASE-YEAST-RXN", "Reactome:R-HSA-428262 \"phytoceramide + H2O => stearate + phytosphingosine\"" ] } } }, { "id": "GO:0070780", "name": "dihydrosphingosine-1-phosphate phosphatase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN3DJ-25", "Reactome:R-HSA-428664 \"SGPP1,2 dephosphorylate sphingoid-1-phosphates\"", "RHEA:27514" ], "previous": [ "MetaCyc:RXN3DJ-25", "Reactome:R-HSA-428664 \"sphinganine 1-phosphate + H2O => sphinganine + orthophosphate\"", "RHEA:27514" ] } } }, { "id": "GO:0070815", "name": "peptidyl-lysine 5-dioxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9630022 \"JMJD6 dimer hydroxylates lysine residues of U2AF2\"" ], "previous": "N/A" } } }, { "id": "GO:0071558", "name": "histone H3K27me2/H3K27me3 demethylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.68", "Reactome:R-HSA-3222593 \"KDM6B demethylates H3K27me3 on p16INK4A promoter\"", "Reactome:R-HSA-5617431 \"Retinoic acid activates HOXA1 chromatin\"", "Reactome:R-HSA-5617887 \"HOXC4 chromatin is activated\"", "Reactome:R-HSA-9822914 \"KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)\"", "Reactome:R-HSA-9822985 \"KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)\"", "RHEA:60224" ], "previous": [ "EC:1.14.11.68", "Reactome:R-HSA-3222593 \"KDM6B demethylates H3K27me3 on p16INK4A promoter\"", "Reactome:R-HSA-5617431 \"Retinoic acid activates HOXA1 chromatin\"", "Reactome:R-HSA-5617887 \"HOXC4 chromatin is activated\"", "RHEA:60224" ] } } }, { "id": "GO:0080049", "name": "L-gulono-1,4-lactone dehydrogenase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-1439", "RHEA:47248" ], "previous": [ "MetaCyc:RXN-1439" ] } } }, { "id": "GO:0080123", "name": "jasmonoyl-L-amino acid ligase activity", "changes": { "xrefs": { "current": [ "EC:6.3.2.52", "RHEA:55772" ], "previous": "N/A" } } }, { "id": "GO:0080132", "name": "fatty acid alpha-hydroxylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5693761 \"FA2H hydroxylates 1,2-saturated fatty acids\"" ], "previous": [ "Reactome:R-HSA-5693761 \"FA2H hydroxylates CERA\"" ] } } }, { "id": "GO:0102682", "name": "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.2.2.n1", "MetaCyc:RXN-4313", "RHEA:48560" ], "previous": [ "MetaCyc:RXN-4313", "RHEA:48560" ] } } }, { "id": "GO:0106032", "name": "snRNA pseudouridine synthase activity", "changes": { "xrefs": { "current": [ "RHEA:51124" ], "previous": "N/A" } } }, { "id": "GO:0106050", "name": "tRNA 2'-O-methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6788668 \"TRMT13 2'-O-methylates adenosine-4 in tRNA\"", "Reactome:R-HSA-6788684 \"TRMT13 2'-O-methylates cytidine-4 in tRNA\"", "Reactome:R-HSA-9024159 \"FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)\"" ], "previous": "N/A" } } }, { "id": "GO:0106155", "name": "peptidyl-lysine 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.63", "Reactome:R-HSA-9629578 \"JMJD7 dimer hydroxlates a lysine residue of DRG2\"", "Reactome:R-HSA-9629591 \"JMJD7 dimer hydroxlates a lysine residue of DRG1\"", "RHEA:57152" ], "previous": [ "EC:1.14.11.63", "RHEA:57152" ] } } }, { "id": "GO:0106156", "name": "peptidyl-lysine 4-dioxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9629946 \"JMJD4:Fe2+ hydroxylates a lysine residue of ETF1\"", "RHEA:57156" ], "previous": [ "RHEA:57156" ] } } }, { "id": "GO:0106157", "name": "peptidyl-arginine 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.73", "Reactome:R-HSA-9629869 \"KDM8:Fe2+ hydroxylates an arginine residue of RPS6\"", "Reactome:R-HSA-9629888 \"KDM8:Fe2+ hydroxylates an arginine residue of RCCD1\"", "RHEA:56744" ], "previous": [ "EC:1.14.11.73", "RHEA:56744" ] } } }, { "id": "GO:0106310", "name": "protein serine kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9729330 \"SRPK1/2 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9821967 \"SRPK1 phosphorylates PRM2 in PRM2:dsDNA\"", "Reactome:R-HSA-9821982 \"SRPK1 phosphorylates PRM1 in PRM1:dsDNA\"", "RHEA:17989" ], "previous": [ "Reactome:R-HSA-9729330 \"SRPK1/2 phosphorylates nucleoprotein\"", "RHEA:17989" ] } } }, { "id": "GO:0106316", "name": "nitrite reductase NADH activity", "changes": { "xrefs": { "current": [ "EC:1.7.1.15", "RHEA:24628" ], "previous": [ "RHEA:24628" ] } } }, { "id": "GO:0120159", "name": "rRNA pseudouridine synthase activity", "changes": { "xrefs": { "current": [ "EC:5.4.99.19", "EC:5.4.99.20", "EC:5.4.99.21", "EC:5.4.99.22", "EC:5.4.99.23", "EC:5.4.99.24", "EC:5.4.99.29", "EC:5.4.99.43", "RHEA:54568" ], "previous": [ "EC:5.4.99.19", "EC:5.4.99.20", "EC:5.4.99.21", "EC:5.4.99.22", "EC:5.4.99.23", "EC:5.4.99.24", "EC:5.4.99.29", "EC:5.4.99.43" ] } } }, { "id": "GO:0140104", "name": "molecular carrier activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-3000074 \"TCN2 binds RCbl in the circulation\"", "Reactome:R-HSA-3000120 \"CBLIF binds RCbl\"", "Reactome:R-HSA-3132759 \"TCN1 binds RCbl\"" ] } } }, { "id": "GO:0140318", "name": "protein transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2248891 \"M6PR transports activated ARSA to the lysosome\"", "Reactome:R-HSA-9662747 \"iRHOM2 transports ADAM17 from ER to the Golgi-network\"", "Reactome:R-HSA-9662818 \"iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane\"" ], "previous": [ "Reactome:R-HSA-9662747 \"iRHOM2 transports ADAM17 from ER to the Golgi-network\"", "Reactome:R-HSA-9662818 \"iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane\"" ] } } }, { "id": "GO:0140355", "name": "cargo receptor ligand activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3000074 \"TCN2 binds RCbl in the circulation\"", "Reactome:R-HSA-3000120 \"CBLIF binds RCbl\"", "Reactome:R-HSA-3132759 \"TCN1 binds RCbl\"" ], "previous": "N/A" } } }, { "id": "GO:0140713", "name": "histone chaperone activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9822185 \"HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA\"" ], "previous": "N/A" } } }, { "id": "GO:0140938", "name": "histone H3 methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3788745 \"EHMT1:EHMT2 methylates IL8 promoter\"", "Reactome:R-HSA-3788748 \"EHMT1:EHMT2 methylates IL6 promoter\"", "Reactome:R-HSA-4827382 \"SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)\"", "Reactome:R-HSA-4827383 \"WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)\"", "Reactome:R-HSA-5159245 \"SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)\"", "Reactome:R-HSA-5205799 \"CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)\"", "Reactome:R-HSA-5244692 \"Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)\"", "Reactome:R-HSA-5634729 \"EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)\"", "Reactome:R-HSA-5634750 \"EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)\"", "Reactome:R-HSA-5634802 \"MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)\"", "Reactome:R-HSA-5637686 \"WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)\"", "Reactome:R-HSA-5638141 \"SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)\"", "Reactome:R-HSA-5638157 \"WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)\"", "Reactome:R-HSA-5638332 \"PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)\"", "Reactome:R-HSA-5638333 \"WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)\"", "Reactome:R-HSA-5649764 \"DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)\"", "Reactome:R-HSA-5649799 \"DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)\"", "Reactome:R-HSA-5649800 \"WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)\"", "Reactome:R-HSA-5649801 \"DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)\"", "Reactome:R-HSA-5649802 \"WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)\"", "Reactome:R-HSA-5661117 \"CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3\"", "Reactome:R-HSA-8936584 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter\"", "Reactome:R-HSA-8936608 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter\"", "Reactome:R-HSA-8937022 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter\"", "Reactome:R-HSA-8937113 \"PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter\"" ], "previous": "N/A" } } }, { "id": "GO:0140939", "name": "histone H4 methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5423038 \"SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)\"", "Reactome:R-HSA-5651654 \"SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)\"", "Reactome:R-HSA-5651657 \"SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)\"" ], "previous": "N/A" } } }, { "id": "GO:0141035", "name": "CTP-dependent diacylglycerol kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.174", "KEGG_REACTION:R09944", "MetaCyc:RXN-12959", "RHEA:25948" ], "previous": [ "EC:2.7.1.174", "KEGG_REACTION:R09944", "MetaCyc:RXN-12959", "Reactome:R-HSA-426240 \"DAG kinase produces phosphatidic acid from DAG\"", "RHEA:25948" ] } } }, { "id": "GO:0141040", "name": "very-long-chain 3-oxoacyl-CoA reductase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.330", "MetaCyc:RXN-7698", "Reactome:R-HSA-548818 \"HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA\"", "RHEA:48680" ], "previous": [ "EC:1.1.1.330", "MetaCyc:RXN-7698", "RHEA:48680" ] } } }, { "id": "GO:0160102", "name": "tRNA (guanine(10)-N2)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.214", "Reactome:R-HSA-6786501 \"TRMT11:TRMT112 methylates guanosine-10 in tRNA\"", "RHEA:43128" ], "previous": [ "EC:2.1.1.214", "RHEA:43128" ] } } }, { "id": "GO:0160104", "name": "tRNA (guanine(26)-N2)-dimethyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.216", "Reactome:R-HSA-6782416 \"TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)\"", "RHEA:43140" ], "previous": [ "EC:2.1.1.216", "RHEA:43140" ] } } }, { "id": "GO:0160106", "name": "tRNA (adenine(9)-N1)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.218", "Reactome:R-HSA-6787594 \"TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9\"", "RHEA:43148" ], "previous": [ "EC:2.1.1.218", "RHEA:43148" ] } } }, { "id": "GO:0160107", "name": "tRNA (adenine(58)-N1)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.220", "Reactome:R-HSA-6783492 \"TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)\"", "Reactome:R-HSA-6787525 \"TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58\"", "RHEA:43152" ], "previous": [ "EC:2.1.1.220", "RHEA:43152" ] } } }, { "id": "GO:1902388", "name": "ceramide 1-phosphate transfer activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5339535 \"CPTP transports C1P from plasma membrane to Golgi membrane\"" ], "previous": [ "Reactome:R-HSA-5339535 \"GLTPD1 transports C1P from plasma membrane to Golgi membrane\"" ] } } }, { "id": "GO:1990817", "name": "poly(A) RNA polymerase activity", "changes": { "xrefs": { "current": [ "EC:2.7.7.19", "MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN", "Reactome:R-HSA-72185 \"mRNA polyadenylation\"", "Reactome:R-HSA-9833031 \"Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs\"", "RHEA:11332" ], "previous": [ "EC:2.7.7.19", "MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN", "Reactome:R-HSA-72185 \"mRNA polyadenylation\"", "RHEA:11332" ] } } } ], "biological_process": [ { "id": "GO:0019042", "name": "viral latency", "changes": { "xrefs": { "current": [ "VZ:3970 \"Viral latency\"" ], "previous": "N/A" } } }, { "id": "GO:0019069", "name": "viral capsid assembly", "changes": { "xrefs": { "current": [ "VZ:1950" ], "previous": "N/A" } } }, { "id": "GO:0019420", "name": "dissimilatory sulfate reduction", "changes": { "xrefs": { "current": [ "MetaCyc:DISSULFRED-PWY", "Wikipedia:Sulfate-reducing_microorganism" ], "previous": [ "MetaCyc:DISSULFRED-PWY" ] } } }, { "id": "GO:0032359", "name": "provirus excision", "changes": { "xrefs": { "current": [ "VZ:3969 \"Viral genome excision\"" ], "previous": "N/A" } } }, { "id": "GO:0039540", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity", "changes": { "xrefs": { "current": [ "VZ:856" ], "previous": "N/A" } } }, { "id": "GO:0039545", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "changes": { "xrefs": { "current": [ "VZ:704" ], "previous": "N/A" } } }, { "id": "GO:0039548", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity", "changes": { "xrefs": { "current": [ "VZ:757" ], "previous": "N/A" } } }, { "id": "GO:0039554", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity", "changes": { "xrefs": { "current": [ "VZ:603" ], "previous": "N/A" } } }, { "id": "GO:0039557", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity", "changes": { "xrefs": { "current": [ "VZ:653" ], "previous": "N/A" } } }, { "id": "GO:0039560", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity", "changes": { "xrefs": { "current": [ "VZ:683" ], "previous": "N/A" } } }, { "id": "GO:0039563", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity", "changes": { "xrefs": { "current": [ "VZ:282" ], "previous": "N/A" } } }, { "id": "GO:0039564", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity", "changes": { "xrefs": { "current": [ "VZ:257" ], "previous": "N/A" } } }, { "id": "GO:0039574", "name": "symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity", "changes": { "xrefs": { "current": [ "VZ:720" ], "previous": "N/A" } } }, { "id": "GO:0039666", "name": "virion attachment to host cell pilus", "changes": { "xrefs": { "current": [ "VZ:981 \"Viral attachment to host cell pilus\"" ], "previous": [ "VZ:981 \"Pilus-mediated viral adsorption onto host cell\"" ] } } }, { "id": "GO:0039678", "name": "symbiont genome ejection through host cell envelope", "changes": { "xrefs": { "current": [ "VZ:986 \"Viral genome ejection through host cell envelope\"" ], "previous": "N/A" } } }, { "id": "GO:0039723", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity", "changes": { "xrefs": { "current": [ "VZ:4477" ], "previous": "N/A" } } }, { "id": "GO:0039724", "name": "symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity", "changes": { "xrefs": { "current": [ "VZ:4478" ], "previous": "N/A" } } }, { "id": "GO:0042784", "name": "symbiont-mediated suppression of host complement activation", "changes": { "xrefs": { "current": [ "VZ:811" ], "previous": "N/A" } } }, { "id": "GO:0044071", "name": "symbiont-mediated perturbation of host cell cycle progression", "changes": { "xrefs": { "current": [ "VZ:1636" ], "previous": "N/A" } } }, { "id": "GO:0046718", "name": "symbiont entry into host cell", "changes": { "xrefs": { "current": [ "VZ:936 \"Virus entry\"" ], "previous": [ "VZ:936" ] } } }, { "id": "GO:0046924", "name": "peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine", "changes": { "xrefs": { "current": [ "PMID:36302388", "RESID:AA0340" ], "previous": [ "RESID:AA0340" ] } } }, { "id": "GO:0061620", "name": "glycolytic process through glucose-6-phosphate", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:GLYCOLYSIS" ] } } }, { "id": "GO:0061633", "name": "transport-coupled glycolytic process through glucose-6-phosphate", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCOLYSIS" ], "previous": "N/A" } } }, { "id": "GO:0075526", "name": "cap snatching", "changes": { "xrefs": { "current": [ "VZ:839 \"Cap snatching\"" ], "previous": [ "VZ:839" ] } } }, { "id": "GO:0085033", "name": "symbiont-mediated activation of host NF-kappaB signal transduction", "changes": { "xrefs": { "current": [ "VZ:841" ], "previous": "N/A" } } }, { "id": "GO:0085034", "name": "symbiont-mediated suppression of host NF-kappaB cascade", "changes": { "xrefs": { "current": [ "VZ:695" ], "previous": "N/A" } } }, { "id": "GO:0098003", "name": "viral tail assembly", "changes": { "xrefs": { "current": [ "VZ:3955 \"Viral tail assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0098004", "name": "virus tail fiber assembly", "changes": { "xrefs": { "current": [ "VZ:3956 \"Viral tail fiber assembly\"" ], "previous": "N/A" } } }, { "id": "GO:0098669", "name": "superinfection exclusion", "changes": { "xrefs": { "current": [ "VZ:3971 \"Superinfection exclusion\"" ], "previous": [ "VZ:3971" ] } } }, { "id": "GO:0098676", "name": "modulation of host virulence by virus", "changes": { "xrefs": { "current": [ "VZ:3965 \"Modulation of host virulence by virus\"" ], "previous": "N/A" } } }, { "id": "GO:0098677", "name": "virion maturation", "changes": { "xrefs": { "current": [ "VZ:1946" ], "previous": [ "UniProtKB-KW:KW-0917", "VZ:1946" ] } } }, { "id": "GO:0098678", "name": "viral tropism 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"VZ:3954" ] } } }, { "id": "GO:0099006", "name": "symbiont entry into host cell via permeabilization of endosomal membrane", "changes": { "xrefs": { "current": "N/A", "previous": [ "VZ:985" ] } } }, { "id": "GO:0099008", "name": "symbiont entry into host cell via permeabilization of inner membrane", "changes": { "xrefs": { "current": "N/A", "previous": [ "VZ:985" ] } } }, { "id": "GO:0099009", "name": "viral genome circularization", "changes": { "xrefs": { "current": [ "VZ:3968 \"Viral genome circularization\"" ], "previous": [ "VZ:3968" ] } } }, { "id": "GO:0099045", "name": "viral extrusion", "changes": { "xrefs": { "current": [ "VZ:3951 \"Viral extrusion\"" ], "previous": [ "VZ:3951" ] } } }, { "id": "GO:0140267", "name": "symbiont entry into host cell via permeabilization of host membrane", "changes": { "xrefs": { "current": [ "VZ:985 \"Viral penetration via permeabilization of host membrane\"" ], "previous": "N/A" } } } ], "cellular_component": [ { "id": "GO:0039628", "name": "T=169 icosahedral viral capsid", "changes": { "xrefs": { "current": [ "VZ:10117 \"T=169 icosahedral capsid\"" ], "previous": "N/A" } } }, { "id": "GO:0098015", "name": "virus tail", "changes": { "xrefs": { "current": [ "VZ:3958 \"Viral tail protein\"" ], "previous": "N/A" } } }, { "id": "GO:0098021", "name": "viral capsid, decoration", "changes": { "xrefs": { "current": [ "VZ:4398 \"Capsid decoration protein\"" ], "previous": "N/A" } } }, { "id": "GO:0098024", "name": "virus tail, fiber", "changes": { "xrefs": { "current": [ "VZ:4416 \"Viral tail fiber protein\"" ], "previous": "N/A" } } }, { "id": "GO:0098025", "name": "virus tail, baseplate", "changes": { "xrefs": { "current": [ "VZ:3957 \"Viral baseplate protein\"" ], "previous": "N/A" } } }, { "id": "GO:0098026", "name": "virus tail, tube", "changes": { "xrefs": { "current": [ "VZ:3960 \"Viral tail tube protein\"" ], "previous": "N/A" } } }, { "id": "GO:0098027", "name": "virus tail, sheath", "changes": { "xrefs": { "current": [ "VZ:3959 \"Viral tail sheath protein\"" ], "previous": "N/A" } } } ] }, "relations": { "biological_process": [ { "id": "GO:0000052", "name": "citrulline metabolic process", "changes": { "is_a": { "current": [ "GO:0170041", "GO:1901605" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0000053", "name": "argininosuccinate metabolic process", "changes": { "is_a": { "current": [ "GO:0006575", "GO:0072350", "GO:0170033", "GO:0170041" ], "previous": [ "GO:0006575", "GO:0072350", "GO:1901605" ] } } }, { "id": "GO:0000162", "name": "tryptophan biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006568", "GO:0008652", "GO:0009073", "GO:0046219", "GO:1901607" ], "previous": [ "GO:0006568", "GO:0009073", "GO:0046219", "GO:1901607" ] } } }, { "id": "GO:0000165", "name": "MAPK cascade", "changes": { "is_a": { "current": [ "GO:0141124" ], "previous": [ "GO:0035556" ] } } }, { "id": "GO:0000821", "name": "regulation of arginine metabolic process", "changes": { "is_a": { "current": [ "GO:0006521" ], "previous": [ "GO:0000820" ] } } }, { "id": "GO:0001692", "name": "histamine metabolic process", "changes": { "is_a": { "current": [ "GO:0006576", "GO:0052803", "GO:0097164" ], "previous": [ "GO:0006576", "GO:0006796", "GO:0052803", "GO:0097164" ] } } }, { "id": "GO:0006083", "name": "acetate metabolic process", "changes": { "is_a": { "current": [ "GO:0032787" ], "previous": [ "GO:0006807", "GO:0032787" ] } } }, { "id": "GO:0006101", "name": "citrate metabolic process", "changes": { "is_a": { "current": [ "GO:0072350" ], "previous": [ "GO:0006807", "GO:0072350" ] } } }, { "id": "GO:0006520", "name": "amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0044238", "GO:0071704" ], "previous": [ "GO:0019752", "GO:0044238", "GO:1901564" ] } } }, { "id": "GO:0006522", "name": "alanine metabolic process", "changes": { "is_a": { "current": [ "GO:1901605" ], "previous": [ "GO:0009078" ] } } }, { "id": "GO:0006523", "name": "alanine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006522", "GO:0008652", "GO:1901607" ], "previous": [ "GO:0006522", "GO:0009079" ] } } }, { "id": "GO:0006524", "name": "alanine catabolic process", "changes": { "is_a": { "current": [ "GO:0006522", "GO:0009063", "GO:1901606" ], "previous": [ "GO:0006522", "GO:0009080" ] } } }, { "id": "GO:0006525", "name": "arginine metabolic process", "changes": { "is_a": { "current": [ "GO:1901605" ], "previous": [ "GO:0009064" ] } } }, { "id": "GO:0006534", "name": "cysteine metabolic process", "changes": { "is_a": { "current": [ "GO:0000096", "GO:1901605" ], "previous": [ "GO:0000096", "GO:0009069" ] } } }, { "id": "GO:0006536", "name": "glutamate metabolic process", "changes": { "is_a": { "current": [ "GO:0009064", "GO:0043648" ], "previous": [ "GO:0009064", "GO:0043603", "GO:0043648" ] } } }, { "id": "GO:0006537", "name": "glutamate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006536", "GO:0009084", "GO:0043650" ], "previous": [ "GO:0006536", "GO:0009084", "GO:0043604", "GO:0043650" ] } } }, { "id": "GO:0006547", "name": "histidine metabolic process", "changes": { "is_a": { "current": [ "GO:0019752", "GO:1901564" ], "previous": [ "GO:0006520" ] } } }, { "id": "GO:0006553", "name": "lysine metabolic process", "changes": { "is_a": { "current": [ "GO:1901605" ], "previous": [ "GO:0009066" ] } } }, { "id": "GO:0006554", "name": "lysine catabolic process", "changes": { "is_a": { "current": [ "GO:0006553", "GO:0009063", "GO:1901606" ], "previous": [ "GO:0006553", "GO:0009068" ] } } }, { "id": "GO:0006581", "name": "acetylcholine catabolic process", "changes": { "is_a": { "current": [ "GO:0008291", "GO:1901575" ], "previous": [ "GO:0008291", "GO:1901565" ] } } }, { "id": "GO:0006591", "name": "ornithine metabolic process", "changes": { "is_a": { "current": [ "GO:0170041", "GO:1901605" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0006592", "name": "ornithine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006591", "GO:0008652", "GO:0170043", "GO:1901607" ], "previous": [ "GO:0006591", "GO:1901607" ] } } }, { "id": "GO:0006593", "name": "ornithine catabolic process", "changes": { "is_a": { "current": [ "GO:0006591", "GO:0009063", "GO:0170044", "GO:1901606" ], "previous": [ "GO:0006591", "GO:0009063", "GO:1901606" ] } } }, { "id": "GO:0006604", "name": "phosphoarginine metabolic process", "changes": { "is_a": { "current": [ "GO:0006599", "GO:0170033", "GO:0170041" ], "previous": [ "GO:0006599", "GO:1901605" ] } } }, { "id": "GO:0006749", "name": "glutathione metabolic process", "changes": { "is_a": { "current": [ "GO:0006518", "GO:0006575", "GO:0006790" ], "previous": [ "GO:0071704" ] } } }, { "id": "GO:0006750", "name": "glutathione biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006749", "GO:0019184", "GO:0042398", "GO:0044272" ], "previous": [ "GO:0006749", "GO:0019184" ] } } }, { "id": "GO:0006751", "name": "glutathione catabolic process", "changes": { "is_a": { "current": [ "GO:0006749", "GO:0042219", "GO:0043171", "GO:0044273" ], "previous": [ "GO:0006749", "GO:1901575" ] } } }, { "id": "GO:0006798", "name": "polyphosphate catabolic process", "changes": { "is_a": { "current": [ "GO:0006797", "GO:0044248", "GO:1901575" ], "previous": [ "GO:0006797", "GO:0044248" ] } } }, { "id": "GO:0006799", "name": "polyphosphate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006797", "GO:0044249", "GO:1901576" ], "previous": [ "GO:0006797", "GO:0044249" ] } } }, { "id": "GO:0006816", "name": "calcium ion transport", "changes": { "is_a": { "current": [ "GO:0030001" ], "previous": [ "GO:0030001", "GO:0071702" ] } } }, { "id": "GO:0006833", "name": "water transport", "changes": { "is_a": { "current": [ "GO:0042044" ], "previous": [ "GO:0042044", "GO:0071702" ] } } }, { "id": "GO:0006846", "name": "acetate transport", "changes": { "is_a": { "current": [ "GO:0015718" ], "previous": [ "GO:0015718", "GO:0071705" ] } } }, { "id": "GO:0006850", "name": "mitochondrial pyruvate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1901475", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1901475" ] } } }, { "id": "GO:0006851", "name": "mitochondrial calcium ion transmembrane transport", "changes": { "is_a": { "current": [ "GO:0070588", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0070588" ] } } }, { "id": "GO:0007249", "name": "canonical NF-kappaB signal transduction", "changes": { "is_a": { "current": [ "GO:0141124" ], "previous": [ "GO:0035556" ] } } }, { "id": "GO:0007263", "name": "nitric oxide mediated signal transduction", "changes": { "is_a": { "current": [ "GO:0141124" ], "previous": [ "GO:0019932" ] } } }, { "id": "GO:0007264", "name": "small GTPase-mediated signal transduction", "changes": { "is_a": { "current": [ "GO:0141124" ], "previous": [ "GO:0035556" ] } } }, { "id": "GO:0007266", "name": "Rho protein signal transduction", "changes": { "is_a": { "current": [ "GO:0007264" ], "previous": [ "GO:0007265" ] } } }, { "id": "GO:0008272", "name": "sulfate transport", "changes": { "is_a": { "current": [ "GO:0015698", "GO:0072348" ], "previous": [ "GO:0015698", "GO:0071705", "GO:0072348" ] } } }, { "id": "GO:0008291", "name": "acetylcholine metabolic process", "changes": { "is_a": { "current": [ "GO:0006807", "GO:1900619" ], "previous": [ "GO:1900619", "GO:1901564" ] } } }, { "id": "GO:0008292", "name": "acetylcholine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008291", "GO:1900620" ], "previous": [ "GO:0008291", "GO:1900620", "GO:1901566" ] } } }, { "id": "GO:0008652", "name": "amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0046394", "GO:1901566" ], "previous": [ "GO:0006520", "GO:0046394", "GO:1901566" ] } } }, { "id": "GO:0009063", "name": "amino acid catabolic process", "changes": { "is_a": { "current": [ "GO:0046395", "GO:1901565" ], "previous": [ "GO:0006520", "GO:0046395", "GO:1901565" ] } } }, { "id": "GO:0009064", "name": "glutamine family amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0170033", "GO:0170039" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0009065", "name": "glutamine family amino acid catabolic process", "changes": { "is_a": { "current": [ "GO:0009064", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0009063", "GO:0009064", "GO:1901606" ] } } }, { "id": "GO:0009066", "name": "aspartate family amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0170033", "GO:0170039" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0009067", "name": "aspartate family amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009066", "GO:0170034", "GO:0170038" ], "previous": [ "GO:0009066", "GO:1901607" ] } } }, { "id": "GO:0009068", "name": "aspartate family amino acid catabolic process", "changes": { "is_a": { "current": [ "GO:0009066", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0009063", "GO:0009066", "GO:1901606" ] } } }, { "id": "GO:0009069", "name": "serine family amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0170033", "GO:0170039" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0009070", "name": "serine family amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009069", "GO:0170034", "GO:0170038" ], "previous": [ "GO:0009069", "GO:1901607" ] } } }, { "id": "GO:0009071", "name": "serine family amino acid catabolic process", "changes": { "is_a": { "current": [ "GO:0009069", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0009063", "GO:0009069", "GO:1901606" ] } } }, { "id": "GO:0009072", "name": "aromatic amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0006520", "GO:0006725", "GO:0019752", "GO:1901360", "GO:1901564" ], "previous": [ "GO:0006520", "GO:0006725", "GO:1901360" ] } } }, { "id": "GO:0009078", "name": "pyruvate family amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0170033", 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"previous": [ "GO:0006520" ] } } }, { "id": "GO:0033487", "name": "pelargonidin 3-O-glucoside biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009813", "GO:1901806" ], "previous": [ "GO:0009718", "GO:1901806" ] } } }, { "id": "GO:0033507", "name": "glucosinolate biosynthetic process from phenylalanine", "changes": { "is_a": { "current": [ "GO:0019752", "GO:0019761" ], "previous": [ "GO:0006520", "GO:0019761" ] } } }, { "id": "GO:0033591", "name": "response to L-ascorbic acid", "changes": { "is_a": { "current": [ "GO:0014070", "GO:0033273", "GO:0034284" ], "previous": [ "GO:0014070", "GO:0033273", "GO:0034284", "GO:1902074" ] } } }, { "id": "GO:0033609", "name": "oxalate metabolic process", "changes": { "is_a": { "current": [ "GO:0043648" ], "previous": [ "GO:0006807", "GO:0043648" ] } } }, { "id": "GO:0034050", "name": "symbiont-induced defense-related programmed cell death", "changes": { "is_a": { "current": [ "GO:0012501", "GO:0140546" ], "previous": [ "GO:0012501", 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"symbiont-mediated suppression of host TRAF-mediated signal transduction", "changes": { "is_a": { "current": [ "GO:0052029" ], "previous": [ "GO:0141076" ] } } }, { "id": "GO:0039537", "name": "symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway", "changes": { "is_a": { "current": [ "GO:0039503", "GO:0052078", "GO:0075111" ], "previous": [ "GO:0039503", "GO:0075111" ] } } }, { "id": "GO:0039580", "name": "symbiont-mediated suppression of host PKR/eIFalpha signaling", "changes": { "is_a": { "current": [ "GO:0019057", "GO:0052029" ], "previous": [ "GO:0019057", "GO:0039503" ] } } }, { "id": "GO:0039592", "name": "symbiont-mediated arrest of host cell cycle during G2/M transition", "changes": { "is_a": { "current": [ "GO:0044071" ], "previous": [ "GO:0060153" ] } } }, { "id": "GO:0039593", "name": "symbiont-mediated perturbation of host exit from mitosis", "changes": { "is_a": { "current": [ "GO:0044071" ], "previous": [ "GO:0060153" ] } } }, { "id": "GO:0039645", "name": "symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint", "changes": { "is_a": { "current": [ "GO:0044071" ], "previous": [ "GO:0060153" ] } } }, { "id": "GO:0039646", "name": "symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint", "changes": { "is_a": { "current": [ "GO:0044071" ], "previous": [ "GO:0060153" ] } } }, { "id": "GO:0039648", "name": "symbiont-mediated perturbation of host protein ubiquitination", "changes": { "is_a": { "current": [ "GO:0044068" ], "previous": [ "GO:0019054" ] }, "relationship": { "current": "N/A", "previous": [ "regulates GO:0016567" ] }, "intersection_of": { "current": "N/A", "previous": [ "is_a GO:0019048", "regulates GO:0016567" ] } } }, { "id": "GO:0039656", "name": "modulation by virus of host gene expression", "changes": { "is_a": { "current": [ "GO:0019054", "GO:0044068" ], "previous": [ "GO:0019054" ] } } }, { "id": "GO:0039666", "name": "virion attachment to host cell pilus", "changes": { "relationship": { "current": [ "part_of GO:0046718" ], "previous": "N/A" } } }, { "id": "GO:0039672", "name": "suppression by virus of host natural killer cell activation", "changes": { "is_a": { "current": [ "GO:0032815", "GO:0039671", "GO:0044068" ], "previous": [ "GO:0032815", "GO:0039671" ] } } }, { "id": "GO:0039678", "name": "symbiont genome ejection through host cell envelope", "changes": { "is_a": { "current": [ "GO:0016032" ], "previous": [ "GO:0046718" ] }, "relationship": { "current": [ "part_of GO:0046718" ], "previous": "N/A" } } }, { "id": "GO:0039699", "name": "evasion of mRNA degradation by host via mRNA cap methylation", "changes": { "is_a": { "current": [ "GO:0141043" ], "previous": [ "GO:0039503" ] } } }, { "id": "GO:0039722", "name": "symbiont-mediated suppression of host toll-like receptor signaling pathway", "changes": { "is_a": { "current": [ "GO:0039503", "GO:0052029" ], "previous": [ "GO:0039503", "GO:0141105" ] } } }, { "id": "GO:0042217", "name": "1-aminocyclopropane-1-carboxylate catabolic process", "changes": { "is_a": { "current": [ "GO:0009063", "GO:0018871", "GO:0170044", "GO:1901606" ], "previous": [ "GO:0009063", "GO:0018871", "GO:1901606" ] } } }, { "id": "GO:0042218", "name": "1-aminocyclopropane-1-carboxylate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008652", "GO:0018871", "GO:0170043", "GO:1901607" ], "previous": [ "GO:0018871", "GO:1901607" ] } } }, { "id": "GO:0042220", "name": "response to cocaine", "changes": { "is_a": { "current": [ "GO:0014070", "GO:0043279", "GO:1901700" ], "previous": [ "GO:0014070", "GO:0043279", "GO:1901700", "GO:1902074" ] } } }, { "id": "GO:0042414", "name": "epinephrine metabolic process", "changes": { "is_a": { "current": [ "GO:0008152" ], "previous": [ "GO:0006584" ] } } }, { "id": "GO:0042418", "name": "epinephrine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009058", "GO:0042414" ], "previous": [ "GO:0042414", "GO:0042423" ] } } }, { "id": "GO:0042419", "name": "epinephrine catabolic process", "changes": { "is_a": { "current": [ "GO:0009056", "GO:0042414" ], "previous": [ "GO:0042414", "GO:0042424" ] } } }, { "id": "GO:0042542", "name": "response to hydrogen peroxide", "changes": { "is_a": { "current": [ "GO:0000302", "GO:0010035" ], "previous": [ "GO:0000302", "GO:0010033", "GO:0010035" ] } } }, { "id": "GO:0042743", "name": "hydrogen peroxide metabolic process", "changes": { "is_a": { "current": [ "GO:0072593" ], "previous": [ "GO:0071704", "GO:0072593" ] } } }, { "id": "GO:0042744", "name": "hydrogen peroxide catabolic process", "changes": { "is_a": { "current": [ "GO:0042743", "GO:0044248" ], "previous": [ "GO:0042743", "GO:0044248", "GO:1901575" ] } } }, { "id": "GO:0042784", "name": "symbiont-mediated suppression of host complement activation", "changes": { "is_a": { "current": [ "GO:0052170" ], "previous": [ "GO:0042783" ] } } }, { "id": "GO:0042851", "name": "L-alanine metabolic process", "changes": { "is_a": { "current": [ "GO:0006522", "GO:0009078" ], "previous": [ "GO:0006522" ] } } }, { "id": "GO:0042852", "name": "L-alanine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006523", "GO:0009079", "GO:0042851" ], "previous": [ "GO:0006523", "GO:0042851" ] } } }, { "id": "GO:0042853", "name": "L-alanine catabolic process", "changes": { "is_a": { "current": [ "GO:0006524", "GO:0009080", "GO:0042851" ], "previous": [ "GO:0006524", "GO:0042851" ] } } }, { "id": "GO:0042854", "name": "eugenol metabolic process", "changes": { "is_a": { "current": [ "GO:0009698", "GO:0018904", "GO:0018958", "GO:0042537", "GO:0120254" ], "previous": [ "GO:0009698", "GO:0018904", "GO:0018958", "GO:0042537" ] } } }, { "id": "GO:0042855", "name": "eugenol biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009699", "GO:0042854", "GO:0046189", "GO:0120255", "GO:1901503" ], "previous": [ "GO:0009699", "GO:0042854", "GO:0046189", "GO:1901503" ] } } }, { "id": "GO:0042856", "name": 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} } }, { "id": "GO:0070100", "name": "negative regulation of chemokine-mediated signaling pathway", "changes": { "is_a": { "current": [ "GO:0001960", "GO:0045744", "GO:0070099" ], "previous": [ "GO:0001960", "GO:0070099" ] } } }, { "id": "GO:0070101", "name": "positive regulation of chemokine-mediated signaling pathway", "changes": { "is_a": { "current": [ "GO:0001961", "GO:0045745", "GO:0070099" ], "previous": [ "GO:0001961", "GO:0070099" ] } } }, { "id": "GO:0070178", "name": "D-serine metabolic process", "changes": { "is_a": { "current": [ "GO:0046416" ], "previous": [ "GO:0009069", "GO:0046416" ] } } }, { "id": "GO:0070179", "name": "D-serine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0046437", "GO:0070178" ], "previous": [ "GO:0009070", "GO:0046437", "GO:0070178" ] } } }, { "id": "GO:0070189", "name": "kynurenine metabolic process", "changes": { "is_a": { "current": [ "GO:0042180", "GO:0042537", "GO:0170041", "GO:1901605" ], "previous": [ "GO:0042180", 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"(S)-scoulerine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0018130", "GO:0033075", "GO:1901362" ], "previous": [ "GO:0018130", "GO:0033075", "GO:1901007", "GO:1901362" ] } } }, { "id": "GO:1901012", "name": "(S)-reticuline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009708", "GO:0018130", "GO:1901362", "GO:1901617" ], "previous": [ "GO:0009708", "GO:0018130", "GO:1901010", "GO:1901362", "GO:1901617" ] } } }, { "id": "GO:1901052", "name": "sarcosine metabolic process", "changes": { "is_a": { "current": [ "GO:0006575", "GO:0170041", "GO:1901605" ], "previous": [ "GO:0006575", "GO:1901605" ] } } }, { "id": "GO:1901053", "name": "sarcosine catabolic process", "changes": { "is_a": { "current": [ "GO:0009063", "GO:0042219", "GO:0170044", "GO:1901052", "GO:1901606" ], "previous": [ "GO:0009063", "GO:0042219", "GO:1901052", "GO:1901606" ] } } }, { "id": "GO:1901054", "name": "sarcosine biosynthetic process", "changes": { "is_a": { "current": [ 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{ "is_a": { "current": [ "GO:1901701", "GO:1902438" ], "previous": [ "GO:1901701", "GO:1902075", "GO:1902438" ] } } }, { "id": "GO:1902617", "name": "response to fluoride", "changes": { "is_a": { "current": [ "GO:0010035" ], "previous": [ "GO:0010035", "GO:1901700", "GO:1902074" ] } } }, { "id": "GO:1902618", "name": "cellular response to fluoride", "changes": { "is_a": { "current": [ "GO:0070887", "GO:1902617" ], "previous": [ "GO:1901701", "GO:1902075", "GO:1902617" ] } } }, { "id": "GO:1902986", "name": "regulation of lysine biosynthetic process via aminoadipic acid", "changes": { "is_a": { "current": [ "GO:0006521", "GO:2000282" ], "previous": [ "GO:2000282" ] } } }, { "id": "GO:1902987", "name": "negative regulation of lysine biosynthetic process via aminoadipic acid", "changes": { "is_a": { "current": [ "GO:0045763", "GO:1902986", "GO:2000283" ], "previous": [ "GO:1902986", "GO:2000283" ] } } }, { "id": "GO:1903075", "name": "pyridoxine import across plasma membrane", "changes": { "is_a": { "current": [ "GO:0098739", "GO:1903092" ], "previous": [ "GO:0098657", "GO:0098739", "GO:1903092" ] } } }, { "id": "GO:1903184", "name": "L-dopa metabolic process", "changes": { "is_a": { "current": [ "GO:0006575", "GO:0009072", "GO:0170033", "GO:0170041" ], "previous": [ "GO:0006575", "GO:0009072", "GO:1901605" ] } } }, { "id": "GO:1903185", "name": "L-dopa biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009073", "GO:0042398", "GO:0170034", "GO:0170043", "GO:1903184" ], "previous": [ "GO:0009073", "GO:0042398", "GO:1901607", "GO:1903184" ] } } }, { "id": "GO:1903195", "name": "regulation of L-dopa biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006521", "GO:2000282" ], "previous": [ "GO:2000282" ] } } }, { "id": "GO:1903196", "name": "negative regulation of L-dopa biosynthetic process", "changes": { "is_a": { "current": [ "GO:0045763", "GO:1903195", "GO:2000283" ], "previous": [ "GO:1903195", "GO:2000283" ] } } }, { "id": "GO:1903197", "name": "positive regulation of L-dopa biosynthetic process", "changes": { "is_a": { "current": [ "GO:0045764", "GO:1903195", "GO:2000284" ], "previous": [ "GO:1903195", "GO:2000284" ] } } }, { "id": "GO:1903248", "name": "regulation of citrulline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006521", "GO:0031326" ], "previous": [ "GO:2000282" ] } } }, { "id": "GO:1903249", "name": "negative regulation of citrulline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0031327", "GO:0045763", "GO:0062014", "GO:1903248" ], "previous": [ "GO:1903248", "GO:2000283" ] } } }, { "id": "GO:1903250", "name": "positive regulation of citrulline biosynthetic process", "changes": { "is_a": { "current": [ "GO:0031328", "GO:0045764", "GO:0062013", "GO:1903248" ], "previous": [ "GO:1903248", "GO:2000284" ] } } }, { "id": "GO:1903252", "name": "hercynylcysteine sulfoxide metabolic process", "changes": { "is_a": { "current": [ "GO:0006790", "GO:0052701", "GO:0170033" ], 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"GO:0098838", "GO:1990542" ] } } }, { "id": "GO:1904959", "name": "regulation of cytochrome-c oxidase activity", "changes": { "is_a": { "current": [ "GO:0010155", "GO:0032412", "GO:0051341", "GO:1904732" ], "previous": [ "GO:0010155", "GO:0032412", "GO:1904732" ] } } }, { "id": "GO:1904960", "name": "positive regulation of cytochrome-c oxidase activity", "changes": { "is_a": { "current": [ "GO:0032414", "GO:0051353", "GO:1904734", "GO:1904959" ], "previous": [ "GO:0032414", "GO:1904734", "GO:1904959" ] } } }, { "id": "GO:1904983", "name": "glycine import into mitochondrion", "changes": { "is_a": { "current": [ "GO:0015816", "GO:0170036", "GO:1902475" ], "previous": [ "GO:0015816", "GO:1902475", "GO:1990542" ] } } }, { "id": "GO:1905130", "name": "carcinine import across plasma membrane", "changes": { "is_a": { "current": [ "GO:0015695", "GO:0042886", "GO:0045117", "GO:0072337", "GO:0098739" ], "previous": [ "GO:0015695", "GO:0042886", "GO:0045117", "GO:0072337", "GO:0098657", 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"cellular response to L-glutamate", "changes": { "is_a": { "current": [ "GO:0071230", "GO:1902065" ], "previous": [ "GO:0071230", "GO:1902065", "GO:1902075" ] } } }, { "id": "GO:1905242", "name": "response to 3,3',5-triiodo-L-thyronine", "changes": { "is_a": { "current": [ "GO:0014070", "GO:0043200" ], "previous": [ "GO:0014070", "GO:0043200", "GO:1902074" ] } } }, { "id": "GO:1905243", "name": "cellular response to 3,3',5-triiodo-L-thyronine", "changes": { "is_a": { "current": [ "GO:0071230", "GO:0071407", "GO:1905242" ], "previous": [ "GO:0071230", "GO:0071407", "GO:1902075", "GO:1905242" ] } } }, { "id": "GO:1905279", "name": "regulation of retrograde transport, endosome to Golgi", "changes": { "is_a": { "current": [ "GO:0032386", "GO:0060627" ], "previous": [ "GO:0060627", "GO:1903649" ] } } }, { "id": "GO:1905280", "name": "negative regulation of retrograde transport, endosome to Golgi", "changes": { "is_a": { "current": [ "GO:0032387", "GO:1905279" ], "previous": [ "GO:1903650", 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"GO:1905827", "name": "positive regulation of selenocysteine metabolic process", "changes": { "is_a": { "current": [ "GO:0031325", "GO:0045764", "GO:0062013", "GO:1905825" ], "previous": [ "GO:0045764", "GO:1905825" ] } } }, { "id": "GO:1990417", "name": "snoRNA release from pre-rRNA", "changes": { "is_a": { "current": [ "GO:0006364" ], "previous": [ "GO:0006364", "GO:0016074" ] } } }, { "id": "GO:1990519", "name": "pyrimidine nucleotide import into mitochondrion", "changes": { "is_a": { "current": [ "GO:0006864", "GO:0072531", "GO:0170036", "GO:1901679" ], "previous": [ "GO:0006864", "GO:0072531", "GO:1901679", "GO:1990542" ] } } }, { "id": "GO:1990540", "name": "mitochondrial manganese ion transmembrane transport", "changes": { "is_a": { "current": [ "GO:0071421", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0071421" ] } } }, { "id": "GO:1990543", "name": "mitochondrial S-adenosyl-L-methionine transmembrane transport", "changes": { "is_a": { "current": [ "GO:1901962", "GO:1990542" 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"changes": { "is_a": { "current": [ "GO:0035350", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0035350" ] } } }, { "id": "GO:1990549", "name": "mitochondrial NAD transmembrane transport", "changes": { "is_a": { "current": [ "GO:0035352", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0035352" ] } } }, { "id": "GO:1990550", "name": "mitochondrial alpha-ketoglutarate transmembrane transport", "changes": { "is_a": { "current": [ "GO:0015742", "GO:1905039", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0015742", "GO:1905039" ] } } }, { "id": "GO:1990551", "name": "mitochondrial 2-oxoadipate transmembrane transport", "changes": { "is_a": { "current": [ "GO:0006835", "GO:1905039", "GO:1990542" ], "previous": [ "GO:0006835", "GO:0006839", "GO:1905039" ] } } }, { "id": "GO:1990553", "name": "mitochondrial 5'-adenylyl sulfate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1902558", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1902558" ] } } }, { "id": "GO:1990554", "name": "mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1902559", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1902559" ] } } }, { "id": "GO:1990555", "name": "mitochondrial oxaloacetate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1902356", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1902356" ] } } }, { "id": "GO:1990556", "name": "mitochondrial isopropylmalate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1902357", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1902357" ] } } }, { "id": "GO:1990557", "name": "mitochondrial sulfate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1902358", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1902358" ] } } }, { "id": "GO:1990558", "name": "mitochondrial malonate(1-) transmembrane transport", "changes": { "is_a": { "current": [ "GO:1901553", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1901553" ] } } }, { "id": "GO:1990559", "name": "mitochondrial coenzyme A transmembrane transport", "changes": { "is_a": { "current": [ "GO:0035349", "GO:1990542" ], "previous": [ "GO:0006839", "GO:0035349" ] } } }, { "id": "GO:1990575", "name": "mitochondrial L-ornithine transmembrane transport", "changes": { "is_a": { "current": [ "GO:1903352", "GO:1990542" ], "previous": [ "GO:0006839", "GO:1903352" ] } } }, { "id": "GO:1990616", "name": "magnesium ion export from mitochondrion", "changes": { "is_a": { "current": [ "GO:0045016", "GO:0170037" ], "previous": [ "GO:0045016" ] } } }, { "id": "GO:1990818", "name": "L-arginine transmembrane export from vacuole", "changes": { "is_a": { "current": [ "GO:0032974", "GO:1902475" ], "previous": [ "GO:0032974", "GO:0072337", "GO:1902475" ] } } }, { "id": "GO:1990983", "name": "regulation of translational initiation by tRNA modification", "changes": { "is_a": { "current": [ "GO:0006400", "GO:0006446" ], "previous": [ "GO:0006400", "GO:0035513" ] } } }, { "id": "GO:2000211", "name": "regulation of glutamate metabolic process", "changes": { "is_a": { "current": [ "GO:0000820" ], "previous": [ "GO:0000820", "GO:0034248" ] } } }, { "id": "GO:2000212", "name": "negative regulation of glutamate metabolic process", "changes": { "is_a": { "current": [ "GO:0031324", "GO:0045763", "GO:0062014", "GO:2000211" ], "previous": [ "GO:0034249", "GO:0045763", "GO:2000211" ] } } }, { "id": "GO:2000213", "name": "positive regulation of glutamate metabolic process", "changes": { "is_a": { "current": [ "GO:0031325", "GO:0045764", "GO:0062013", "GO:2000211" ], "previous": [ "GO:0034250", "GO:0045764", "GO:2000211" ] } } }, { "id": "GO:2000215", "name": "negative regulation of proline metabolic process", "changes": { "is_a": { "current": [ "GO:0031324", "GO:0045763", "GO:0062014", "GO:2000214" ], "previous": [ "GO:0045763", "GO:2000214" ] } } }, { "id": "GO:2000216", "name": "positive regulation of proline metabolic process", "changes": { "is_a": { "current": [ "GO:0031325", "GO:0045764", "GO:0062013", "GO:2000214" ], "previous": [ "GO:0045764", "GO:2000214" ] } } }, { "id": "GO:2000282", "name": "regulation of cellular amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0031326", "GO:0051171", "GO:0062012" ], "previous": [ "GO:0006521", "GO:0031326" ] } } }, { "id": "GO:2000283", "name": "negative regulation of amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0031327", "GO:0051172", "GO:0062014", "GO:2000282" ], "previous": [ "GO:0031327", "GO:0045763", "GO:2000282" ] } } }, { "id": "GO:2000284", "name": "positive regulation of amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0031328", "GO:0051173", "GO:0062013", "GO:2000282" ], "previous": [ "GO:0031328", "GO:0045764", "GO:2000282" ] } } }, { "id": "GO:2000890", "name": "cellodextrin catabolic process", "changes": { "is_a": { "current": [ "GO:0009313", "GO:1901027", "GO:2000889" ], "previous": [ "GO:0009251", 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{ "id": "GO:0010348", "name": "lithium:proton antiporter activity", "changes": { "is_a": { "current": [ "GO:0051139" ], "previous": [ "GO:0051139", "GO:1901702" ] } } }, { "id": "GO:0010420", "name": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "changes": { "relationship": { "current": [ "part_of GO:0006744" ], "previous": "N/A" } } }, { "id": "GO:0015079", "name": "potassium ion transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0046873" ], "previous": [ "GO:0046873", "GO:1901702" ] } } }, { "id": "GO:0015081", "name": "sodium ion transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0046873" ], "previous": [ "GO:0046873", "GO:1901702" ] } } }, { "id": "GO:0015085", "name": "calcium ion transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0046873" ], "previous": [ "GO:0046873", "GO:1901702" ] } } }, { "id": "GO:0015091", "name": "ferric iron transmembrane transporter activity", 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}, { "id": "GO:0015200", "name": "methylammonium transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0005275", "GO:0015101" ], "previous": [ "GO:0005275", "GO:0015101", "GO:1901702" ] } } }, { "id": "GO:0015217", "name": "ADP transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0000295", "GO:0005346", "GO:0008514" ], "previous": [ "GO:0000295", "GO:0005346", "GO:0008514", "GO:1901702" ] } } }, { "id": "GO:0015220", "name": "choline transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015101" ], "previous": [ "GO:0015651", "GO:1901702" ] } } }, { "id": "GO:0015229", "name": "L-ascorbic acid transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015145", "GO:0046943", "GO:0090482" ], "previous": [ "GO:0015145", "GO:0046943", "GO:0090482", "GO:1901702" ] } } }, { "id": "GO:0015350", "name": "methotrexate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0005310", 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"name": "glucan endo-1,3-beta-D-glucosidase activity", "changes": { "is_a": { "current": [ "GO:0015926" ], "previous": [ "GO:0008422" ] } } }, { "id": "GO:0043295", "name": "glutathione binding", "changes": { "is_a": { "current": [ "GO:0043168", "GO:0072341", "GO:1900750", "GO:1901681" ], "previous": [ "GO:0043168" ] } } }, { "id": "GO:0043682", "name": "P-type divalent copper transporter activity", "changes": { "is_a": { "current": [ "GO:0005375", "GO:0015662", "GO:0019829" ], "previous": [ "GO:0005375", "GO:0015662", "GO:0019829", "GO:1901682", "GO:1901702" ] } } }, { "id": "GO:0043759", "name": "2-methylbutanoate-CoA ligase activity", "changes": { "is_a": { "current": [ "GO:0031955" ], "previous": [ "GO:0031956" ] } } }, { "id": "GO:0043872", "name": "lysine:cadaverine antiporter activity", "changes": { "is_a": { "current": [ "GO:0015101", "GO:0015171", "GO:0015297" ], "previous": [ "GO:0015101", "GO:0015171", "GO:0015297", "GO:1901702" ] } } }, { "id": "GO:0043879", "name": 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"GO:0016901" ], "previous": [ "GO:0016614" ] } } }, { "id": "GO:0050218", "name": "propionate-CoA ligase activity", "changes": { "is_a": { "current": [ "GO:0031955" ], "previous": [ "GO:0016405", "GO:0016878" ] } } }, { "id": "GO:0050833", "name": "pyruvate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028" ], "previous": [ "GO:0008028", "GO:1901702" ] } } }, { "id": "GO:0051379", "name": "epinephrine binding", "changes": { "is_a": { "current": [ "GO:0005488" ], "previous": [ "GO:1901338" ] } } }, { "id": "GO:0051870", "name": "methotrexate binding", "changes": { "is_a": { "current": [ "GO:0031406", "GO:0033218", "GO:0097159", "GO:1901363" ], "previous": [ "GO:0031406", "GO:0033218", "GO:0072341", "GO:0097159", "GO:1901363" ] } } }, { "id": "GO:0061459", "name": "L-arginine transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015174", "GO:0015179" ], "previous": [ "GO:0015174", "GO:0015179", "GO:0072349" ] } } }, { "id": "GO:0061542", "name": "3-demethylubiquinol-n 3-O-methyltransferase activity", "changes": { "relationship": { "current": [ "part_of GO:0006744" ], "previous": "N/A" } } }, { "id": "GO:0061797", "name": "pH-gated chloride channel activity", "changes": { "is_a": { "current": [ "GO:0005254", "GO:0160128" ], "previous": [ "GO:0005254", "GO:0022836" ] } } }, { "id": "GO:0061809", "name": "NAD+ nucleotidase, cyclic ADP-ribose generating", "changes": { "is_a": { "current": [ "GO:0016799" ], "previous": [ "GO:0003953" ] }, "relationship": { "current": "N/A", "previous": [ "has_part GO:0061811", "has_part GO:0061812" ] } } }, { "id": "GO:0070909", "name": "glutamate:gamma-aminobutyric acid antiporter activity", "changes": { "is_a": { "current": [ "GO:0015185", "GO:0015297", "GO:0015355" ], "previous": [ "GO:0015185", "GO:0015297", "GO:0015355", "GO:0042887", "GO:1901702" ] } } }, { "id": "GO:0071164", "name": "RNA trimethylguanosine synthase activity", "changes": { "is_a": { "current": [ "GO:0008173", "GO:0008757" ], "previous": [ "GO:0008173" ] } } }, { "id": "GO:0090422", "name": "thiamine pyrophosphate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008514", "GO:0015234", "GO:0015605", "GO:0015651" ], "previous": [ "GO:0008514", "GO:0015234", "GO:0015605", "GO:0015651", "GO:1901702" ] } } }, { "id": "GO:0097079", "name": "selenite:proton symporter activity", "changes": { "is_a": { "current": [ "GO:0015295" ], "previous": [ "GO:0015295", "GO:1901702" ] } } }, { "id": "GO:0097253", "name": "beta-hydroxybutyrate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015245", "GO:0015665" ], "previous": [ "GO:0015245", "GO:0015665", "GO:1901702" ] } } }, { "id": "GO:0102025", "name": "ABC-type thiosulfate transporter activity", "changes": { "is_a": { "current": [ "GO:0043225", "GO:0140359", "GO:1901682" ], "previous": [ "GO:0043225", "GO:0140359", "GO:1901682", "GO:1901702" ] } } }, { "id": "GO:0106316", "name": "nitrite reductase NADH activity", "changes": { "is_a": { "current": [ "GO:0098809" ], "previous": [ "GO:0008942" ] } } }, { "id": "GO:0140485", "name": "5-aminolevulinic acid transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028", "GO:0015101", "GO:0015171" ], "previous": [ "GO:0008028", "GO:0015101", "GO:0015171", "GO:1901702" ] } } }, { "id": "GO:0140812", "name": "orotate:monoatomic anion antiporter activity", "changes": { "is_a": { "current": [ "GO:0008509", "GO:0015297", "GO:0015355", "GO:0022853" ], "previous": [ "GO:0008509", "GO:0015297", "GO:0015355", "GO:0022853", "GO:1901702" ] } } }, { "id": "GO:1901238", "name": "ABC-type tungstate transporter activity", "changes": { "is_a": { "current": [ "GO:0043225", "GO:0140359" ], "previous": [ "GO:0043225", "GO:0140359", "GO:1901702" ] } } }, { "id": "GO:1901239", "name": "malonate(1-) transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0005310" ], "previous": [ "GO:0005310", "GO:1901702" ] } } }, { "id": "GO:1901974", "name": "glycerate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028", "GO:0015144", "GO:0042879" ], "previous": [ "GO:0042879" ] } } }, { "id": "GO:1902485", "name": "L-cysteine binding", "changes": { "is_a": { "current": [ "GO:0016597", "GO:0043169", "GO:1901681" ], "previous": [ "GO:0016597", "GO:0043169", "GO:0072341", "GO:1901681" ] } } }, { "id": "GO:1903135", "name": "cupric ion binding", "changes": { "is_a": { "current": [ "GO:0005507" ], "previous": [ "GO:0005507", "GO:1901681" ] } } }, { "id": "GO:1903264", "name": "nitrate reductase activity involved in anaerobic electron transport chain", "changes": { "is_a": { "current": [ "GO:0008940" ], "previous": [ "GO:0008940", "GO:0009055" ] } } }, { "id": "GO:1903425", "name": "fluoride transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008509", "GO:0015103" ], "previous": [ "GO:0008509", "GO:0015103", "GO:1901702" ] } } }, { "id": "GO:2001080", "name": "chitosan binding", "changes": { "is_a": { "current": [ "GO:0043169", "GO:0097367" ], "previous": [ "GO:0097367" ] } } } ], "cellular_component": [ { "id": "GO:0005905", "name": "clathrin-coated pit", "changes": { "is_a": { "current": [ "GO:0016020" ], "previous": [ "GO:0098590" ] } } }, { "id": "GO:0031533", "name": "mRNA capping enzyme complex", "changes": { "is_a": { "current": [ "GO:0140513" ], "previous": [ "GO:0034708", "GO:0140513" ] } } }, { "id": "GO:0033643", "name": "host cell part", "changes": { "relationship": { "current": "N/A", "previous": [ "part_of GO:0043657" ] }, "intersection_of": { "current": "N/A", "previous": [ "is_a GO:0018995", "part_of GO:0043657" ] } } }, { "id": "GO:0045251", "name": "electron transfer flavoprotein complex", "changes": { "is_a": { "current": [ "GO:0032991" ], "previous": [ "GO:1990204" ] } } } ] } } }