CHANGES IN GO ONTOLOGY SUMMARY: CURRENT RELEASE release_date 2024-01-04 valid_terms 42454 obsolete_terms 5249 merged_terms 2441 biological_process_terms 27196 molecular_function_terms 11196 cellular_component_terms 4062 meta_statements 290095 cross_references 25592 terms_relations 85361 SUMMARY: PREVIOUS RELEASE release_date 2023-11-15 valid_terms 42769 obsolete_terms 4889 merged_terms 2441 biological_process_terms 27473 molecular_function_terms 11235 cellular_component_terms 4061 meta_statements 292132 cross_references 25492 terms_relations 86112 SUMMARY: DIFF BETWEEN RELEASES changes_created_terms 44 changes_valid_terms -315 changes_obsolete_terms 359 changes_merged_terms 0 changes_biological_process_terms -277 changes_molecular_function_terms -39 changes_cellular_component_terms 1 changes_meta_statements 566 changes_meta_statements_by_term 334 changes_cross_references 610 changes_cross_references_by_term 225 changes_relations 724 changes_relations_by_term 696 DETAILED CHANGES 44 CREATED TERMS biological_process GO:0141115 symbiont-mediated suppression of host complement activation by inactivation of complement proteins biological_process GO:0141116 symbiont-mediated suppression of host complement activation by complement sequestering biological_process GO:0141117 symbiont-mediated suppression of host complement activation by recruitment of complement control protein biological_process GO:0141119 chromosomal DNA methylation maintenance following DNA replication biological_process GO:0141123 dermonecrosis in another organism biological_process GO:0141124 intracellular signaling cassette biological_process GO:0141127 symbiont-mediated perturbation of host Rab signal transduction biological_process GO:0141128 symbiont-mediated non-specific activation of host T-cells biological_process GO:0141129 symbiont-mediated suppression of host signal transduction pathway via antagonism of host cell surface receptor biological_process GO:0141130 symbiont-mediated inactivation of host ribosome biological_process GO:0141132 defense response to host biological_process GO:0141134 symbiont-mediated activation of host signal transduction pathway via agonism of host cell surface receptor biological_process GO:0141135 symbiont-mediated suppression of host chemokine signal transduction pathway biological_process GO:0141137 positive regulation of gene expression, epigenetic biological_process GO:0160127 protein-RNA covalent cross-linking repair biological_process GO:0160131 sperm migration through the uterotubal junction biological_process GO:0160135 phospholipase C-activating endothelin receptor signaling pathway biological_process GO:0170033 L-amino acid metabolic process biological_process GO:0170034 L-amino acid biosynthetic process biological_process GO:0170035 L-amino acid catabolic process biological_process GO:0170036 import into the mitochondrion biological_process GO:0170037 export from the mitochondrion biological_process GO:0170038 proteinogenic amino acid biosynthetic process biological_process GO:0170039 proteinogenic amino acid metabolic process biological_process GO:0170040 proteinogenic amino acid catabolic process biological_process GO:0170041 non-proteinogenic amino acid metabolic process biological_process GO:0170043 non-proteinogenic amino acid biosynthetic process biological_process GO:0170044 non-proteinogenic amino acid catabolic process biological_process GO:0180027 inner nuclear membrane-associated protein degradation pathway biological_process GO:0180029 phosphate ion export across plasma membrane molecular_function GO:0141118 nitric oxide dioxygenase activity, heme protein as donor molecular_function GO:0141122 nitrogen-oxygen hydrolyase activity molecular_function GO:0141125 tRNA-queuosine(34) galactosyltransferase activity molecular_function GO:0141126 short-chain fatty acyl-CoA hydrolase activity molecular_function GO:0141131 DNA N6-methyladenine demethylase activity molecular_function GO:0141133 diphthine methyl ester synthase activity molecular_function GO:0160125 pH-gated sodium channel activity molecular_function GO:0160126 pH-gated calcium channel activity molecular_function GO:0160128 pH-gated monoatomic ion channel activity molecular_function GO:0160129 protein-DNA covalent cross-linking activity molecular_function GO:0160133 bicarbonate channel activity molecular_function GO:0160134 protein-RNA sequence-specific adaptor activity cellular_component GO:0160132 meisosome cellular_component GO:0180028 mitotic spindle pole body attachment site 359 OBSOLETED TERMS CHANGES biological_process GO:0000412 histone peptidyl-prolyl isomerization biological_process GO:0002195 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis biological_process GO:0006407 rRNA export from nucleus biological_process GO:0007227 signal transduction downstream of smoothened biological_process GO:0007228 positive regulation of hh target transcription factor activity biological_process GO:0007303 cytoplasmic transport, nurse cell to oocyte biological_process GO:0009444 pyruvate oxidation biological_process GO:0010390 histone monoubiquitination biological_process GO:0010452 histone H3-K36 methylation biological_process GO:0016570 histone modification biological_process GO:0016571 histone methylation biological_process GO:0016573 histone acetylation biological_process GO:0016574 histone ubiquitination biological_process GO:0016575 histone deacetylation biological_process GO:0016577 histone demethylation biological_process GO:0016578 histone deubiquitination biological_process GO:0018069 peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone biological_process GO:0018081 peptide cross-linking via lanthionine or 3-methyl-lanthionine biological_process GO:0018096 peptide cross-linking via S-(2-aminovinyl)-D-cysteine biological_process GO:0018124 peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone biological_process GO:0018132 peptide cross-linking via L-cysteine oxazolecarboxylic acid biological_process GO:0018133 peptide cross-linking via L-cysteine oxazolinecarboxylic acid biological_process GO:0018134 peptide cross-linking via glycine oxazolecarboxylic acid biological_process GO:0018137 peptide cross-linking via glycine thiazolecarboxylic acid biological_process GO:0018138 peptide cross-linking via L-serine thiazolecarboxylic acid biological_process GO:0018139 peptide cross-linking via L-phenylalanine thiazolecarboxylic acid biological_process GO:0018140 peptide cross-linking via L-cysteine thiazolecarboxylic acid biological_process GO:0018141 peptide cross-linking via L-lysine thiazolecarboxylic acid biological_process GO:0018142 protein-DNA covalent cross-linking biological_process GO:0018145 protein-DNA covalent cross-linking via peptidyl-serine biological_process GO:0018150 peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine biological_process GO:0018151 peptide cross-linking via L-histidyl-L-tyrosine biological_process GO:0018152 peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine biological_process GO:0018154 peptide cross-linking via (2R,6R)-lanthionine biological_process GO:0018155 peptide cross-linking via sn-(2S,6R)-lanthionine biological_process GO:0018156 peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine biological_process GO:0018157 peptide cross-linking via an oxazole or thiazole biological_process GO:0018162 peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine biological_process GO:0018163 protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine biological_process GO:0018164 protein-DNA covalent cross-linking via peptidyl-threonine biological_process GO:0018232 peptide cross-linking via S-(L-isoglutamyl)-L-cysteine biological_process GO:0018233 peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine biological_process GO:0018234 peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine biological_process GO:0018253 peptide cross-linking via 5-imidazolinone glycine biological_process GO:0018274 peptide cross-linking via L-lysinoalanine biological_process GO:0018313 peptide cross-linking via L-alanyl-5-imidazolinone glycine biological_process GO:0018908 organosulfide cycle biological_process GO:0019055 perturbation by virus of host cell cycle regulation biological_process GO:0019419 sulfate reduction biological_process GO:0019424 sulfide oxidation, using siroheme sulfite reductase biological_process GO:0019426 bisulfite reduction biological_process GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan biological_process GO:0019926 peptidyl-tryptophan oxidation to tryptophyl quinone biological_process GO:0019927 peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone biological_process GO:0019928 peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid biological_process GO:0019929 peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid biological_process GO:0019932 second-messenger-mediated signaling biological_process GO:0021808 cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration biological_process GO:0021880 Notch signaling pathway involved in forebrain neuron fate commitment biological_process GO:0030433 ubiquitin-dependent ERAD pathway biological_process GO:0030959 peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine biological_process GO:0030960 peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine biological_process GO:0031056 regulation of histone modification biological_process GO:0031060 regulation of histone methylation biological_process GO:0031061 negative regulation of histone methylation biological_process GO:0031062 positive regulation of histone methylation biological_process GO:0031063 regulation of histone deacetylation biological_process GO:0031064 negative regulation of histone deacetylation biological_process GO:0031065 positive regulation of histone deacetylation biological_process GO:0032015 regulation of Ran protein signal transduction biological_process GO:0032016 negative regulation of Ran protein signal transduction biological_process GO:0032017 positive regulation of Ran protein signal transduction biological_process GO:0033169 histone H3-K9 demethylation biological_process GO:0033182 regulation of histone ubiquitination biological_process GO:0033183 negative regulation of histone ubiquitination biological_process GO:0033184 positive regulation of histone ubiquitination biological_process GO:0033522 histone H2A ubiquitination biological_process GO:0033523 histone H2B ubiquitination biological_process GO:0034720 histone H3-K4 demethylation biological_process GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific biological_process GO:0034729 histone H3-K79 methylation biological_process GO:0034770 histone H4-K20 methylation biological_process GO:0034772 histone H4-K20 dimethylation biological_process GO:0034773 histone H4-K20 trimethylation biological_process GO:0034968 histone lysine methylation biological_process GO:0034969 histone arginine methylation biological_process GO:0034970 histone H3-R2 methylation biological_process GO:0034971 histone H3-R17 methylation biological_process GO:0034972 histone H3-R26 methylation biological_process GO:0035065 regulation of histone acetylation biological_process GO:0035066 positive regulation of histone acetylation biological_process GO:0035067 negative regulation of histone acetylation biological_process GO:0035518 histone H2A monoubiquitination biological_process GO:0035521 monoubiquitinated histone deubiquitination biological_process GO:0035522 monoubiquitinated histone H2A deubiquitination biological_process GO:0035616 histone H2B conserved C-terminal lysine deubiquitination biological_process GO:0035975 carbamoyl phosphate catabolic process biological_process GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process biological_process GO:0036123 histone H3-K9 dimethylation biological_process GO:0036124 histone H3-K9 trimethylation biological_process GO:0036210 protein modification process in another organism biological_process GO:0036351 histone H2A-K13 ubiquitination biological_process GO:0036352 histone H2A-K15 ubiquitination biological_process GO:0036353 histone H2A-K119 monoubiquitination biological_process GO:0038008 TRAF-mediated signal transduction biological_process GO:0039506 modulation by virus of host molecular function biological_process GO:0039507 suppression by virus of host molecular function biological_process GO:0039513 suppression by virus of host catalytic activity biological_process GO:0039516 modulation by virus of host catalytic activity biological_process GO:0039573 suppression by virus of host complement activation biological_process GO:0039644 suppression by virus of host NF-kappaB cascade biological_process GO:0039652 induction by virus of host NF-kappaB cascade biological_process GO:0039667 viral entry into host cell via pilus retraction biological_process GO:0039668 viral entry into host cell via pilus basal pore biological_process GO:0039669 viral entry into host cell via pilus retraction and membrane fusion biological_process GO:0039707 virus-mediated pore formation in host cell membrane biological_process GO:0042785 evasion of host immune response via modulation of host cytokine network biological_process GO:0043966 histone H3 acetylation biological_process GO:0043967 histone H4 acetylation biological_process GO:0043968 histone H2A acetylation biological_process GO:0043969 histone H2B acetylation biological_process GO:0043970 histone H3-K9 acetylation biological_process GO:0043971 histone H3-K18 acetylation biological_process GO:0043972 histone H3-K23 acetylation biological_process GO:0043973 histone H3-K4 acetylation biological_process GO:0043974 histone H3-K27 acetylation biological_process GO:0043977 histone H2A-K5 acetylation biological_process GO:0043979 histone H2B-K5 acetylation biological_process GO:0043980 histone H2B-K12 acetylation biological_process GO:0043981 histone H4-K5 acetylation biological_process GO:0043982 histone H4-K8 acetylation biological_process GO:0043983 histone H4-K12 acetylation biological_process GO:0043984 histone H4-K16 acetylation biological_process GO:0043985 histone H4-R3 methylation biological_process GO:0044000 movement in host biological_process GO:0044032 modulation by symbiont of indole acetic acid levels in host biological_process GO:0044072 suppression of host cell cycle progression biological_process GO:0044154 histone H3-K14 acetylation biological_process GO:0044534 envenomation resulting in modulation of apoptotic process in another organism biological_process GO:0044627 modulation of complement activation, classical pathway in another organism biological_process GO:0044628 positive regulation of complement activation, classical pathway in another organism biological_process GO:0044629 negative regulation of complement activation, classical pathway in another organism biological_process GO:0044630 modulation of complement activation, lectin pathway in another organism biological_process GO:0044631 positive regulation of complement activation, lectin pathway in another organism biological_process GO:0044632 negative regulation of complement activation, lectin pathway in another organism biological_process GO:0044633 modulation of complement activation, alternative pathway in another organism biological_process GO:0044634 negative regulation of complement activation, alternative pathway in another organism biological_process GO:0044635 positive regulation of complement activation, alternative pathway in another organism biological_process GO:0044636 envenomation resulting in modulation of complement activation, classical pathway in another organism biological_process GO:0044637 envenomation resulting in negative regulation of complement activation, classical pathway in another organism biological_process GO:0044638 envenomation resulting in positive regulation of complement activation, classical pathway in another organism biological_process GO:0044639 envenomation resulting in modulation of complement activation, lectin pathway in another organism biological_process GO:0044640 envenomation resulting in negative regulation of complement activation, lectin pathway in another organism biological_process GO:0044641 envenomation resulting in positive regulation of complement activation, lectin pathway in another organism biological_process GO:0044642 envenomation resulting in modulation of complement activation, alternative pathway in another organism biological_process GO:0044643 envenomation resulting in positive regulation of complement activation, alternative pathway in another organism biological_process GO:0044644 envenomation resulting in negative regulation of complement activation, alternative pathway in another organism biological_process GO:0044645 modulation of complement activation in another organism biological_process GO:0044646 envenomation resulting in modulation of complement activation in another organism biological_process GO:0044648 histone H3-K4 dimethylation biological_process GO:0044832 induction by virus of host cytokine production biological_process GO:0044846 negative regulation by symbiont of indole acetic acid levels in host biological_process GO:0045326 protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine biological_process GO:0045327 protein-DNA covalent cross-linking via peptidyl-tyrosine biological_process GO:0046792 suppression by virus of host cell cycle arrest biological_process GO:0046804 peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide biological_process GO:0048108 peptide cross-linking via 4-amino-3-isothiazolidinone biological_process GO:0048109 peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine biological_process GO:0050739 peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium biological_process GO:0050745 peptide cross-linking via L-cysteinyl-5-imidazolinone glycine biological_process GO:0050837 peptide cross-linking via L-cysteinyl-L-selenocysteine biological_process GO:0051567 histone H3-K9 methylation biological_process GO:0051568 histone H3-K4 methylation biological_process GO:0051569 regulation of histone H3-K4 methylation biological_process GO:0051570 regulation of histone H3-K9 methylation biological_process GO:0051571 positive regulation of histone H3-K4 methylation biological_process GO:0051572 negative regulation of histone H3-K4 methylation biological_process GO:0051573 negative regulation of histone H3-K9 methylation biological_process GO:0051574 positive regulation of histone H3-K9 methylation biological_process GO:0052019 modulation by symbiont of host hormone or growth regulator levels biological_process GO:0052021 modulation by symbiont of ethylene levels in host biological_process GO:0052022 modulation by symbiont of jasmonic acid levels in host biological_process GO:0052023 modulation by symbiont of salicylic acid levels in host biological_process GO:0052024 positive regulation by symbiont of hormone or growth regulator levels in host biological_process GO:0052053 negative regulation by symbiont of host catalytic activity biological_process GO:0052055 modulation by symbiont of host molecular function biological_process GO:0052062 induction by symbiont of host phytoalexin production biological_process GO:0052074 positive regulation by symbiont of host salicylic acid-mediated defense response biological_process GO:0052075 induction by symbiont of host jasmonic acid-mediated defense response biological_process GO:0052102 positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway biological_process GO:0052104 induction by symbiont of host systemic acquired resistance biological_process GO:0052148 modulation by symbiont of host catalytic activity biological_process GO:0052344 positive regulation by symbiont of host phytoalexin production biological_process GO:0052390 induction by symbiont of host innate immune response biological_process GO:0052489 negative regulation by host of symbiont programmed cell death biological_process GO:0052559 induction by symbiont of host immune response biological_process GO:0060153 perturbation by virus of host cell cycle progression biological_process GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation biological_process GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation biological_process GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation biological_process GO:0061085 regulation of histone H3-K27 methylation biological_process GO:0061086 negative regulation of histone H3-K27 methylation biological_process GO:0061087 positive regulation of histone H3-K27 methylation biological_process GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development biological_process GO:0061291 canonical Wnt signaling pathway involved in ureteric bud branching biological_process GO:0061293 canonical Wnt signaling pathway involved in mesonephric nephron development biological_process GO:0061359 regulation of Wnt signaling pathway by Wnt protein secretion biological_process GO:0061647 histone H3-K9 modification biological_process GO:0061765 perturbation by virus of host non-canonical NF-kappaB signal transduction biological_process GO:0070076 histone lysine demethylation biological_process GO:0070078 histone H3-R2 demethylation biological_process GO:0070079 histone H4-R3 demethylation biological_process GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process GO:0070512 positive regulation of histone H4-K20 methylation biological_process GO:0070535 histone H2A K63-linked ubiquitination biological_process GO:0070537 histone H2A K63-linked deubiquitination biological_process GO:0070544 histone H3-K36 demethylation biological_process GO:0070734 histone H3-K27 methylation biological_process GO:0070932 histone H3 deacetylation biological_process GO:0070933 histone H4 deacetylation biological_process GO:0071557 histone H3-K27 demethylation biological_process GO:0071572 histone H3-K56 deacetylation biological_process GO:0071712 ER-associated misfolded protein catabolic process biological_process GO:0071847 TNFSF11-mediated signaling pathway biological_process GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling biological_process GO:0071894 histone H2B conserved C-terminal lysine ubiquitination biological_process GO:0075112 perturbation of host transmembrane receptor-mediated signal transduction biological_process GO:0075114 symbiont-mediated suppression of host transmembrane receptor-mediated signal transduction biological_process GO:0075343 modulation by symbiont of abscisic acid levels in host biological_process GO:0080182 histone H3-K4 trimethylation biological_process GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate biological_process GO:0086094 positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction biological_process GO:0086096 adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process biological_process GO:0086102 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate biological_process GO:0090226 regulation of microtubule nucleation by Ran protein signal transduction biological_process GO:0090239 regulation of histone H4 acetylation biological_process GO:0090240 positive regulation of histone H4 acetylation biological_process GO:0090241 negative regulation of histone H4 acetylation biological_process GO:0097043 histone H3-K56 acetylation biological_process GO:0097198 histone H3-K36 trimethylation biological_process GO:0097290 alpha-ribazole biosynthetic process biological_process GO:0097676 histone H3-K36 dimethylation biological_process GO:0097692 histone H3-K4 monomethylation biological_process GO:0098532 histone H3-K27 trimethylation biological_process GO:0140192 regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process biological_process GO:0140193 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process biological_process GO:0140194 negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process biological_process GO:0140195 positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process biological_process GO:0140200 adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate biological_process GO:0140655 mitochondrial proliferation biological_process GO:0141075 symbiont-mediated suppression of host JAK-STAT cascade biological_process GO:0141076 symbiont-mediated suppression of host TRAF-mediated signal transduction biological_process GO:0141077 suppression of host interferon-mediated signaling pathway biological_process GO:0141105 symbiont-mediated suppression of host toll-like receptor signal transduction biological_process GO:1900109 regulation of histone H3-K9 dimethylation biological_process GO:1900110 negative regulation of histone H3-K9 dimethylation biological_process GO:1900111 positive regulation of histone H3-K9 dimethylation biological_process GO:1900112 regulation of histone H3-K9 trimethylation biological_process GO:1900113 negative regulation of histone H3-K9 trimethylation biological_process GO:1900114 positive regulation of histone H3-K9 trimethylation biological_process GO:1900992 (-)-secologanin metabolic process biological_process GO:1900993 (-)-secologanin catabolic process biological_process GO:1901007 (S)-scoulerine metabolic process biological_process GO:1901010 (S)-reticuline metabolic process biological_process GO:1901083 pyrrolizidine alkaloid metabolic process biological_process GO:1901101 gramicidin S metabolic process biological_process GO:1901102 gramicidin S catabolic process biological_process GO:1901314 regulation of histone H2A K63-linked ubiquitination biological_process GO:1901315 negative regulation of histone H2A K63-linked ubiquitination biological_process GO:1901316 positive regulation of histone H2A K63-linked ubiquitination biological_process GO:1901585 regulation of acid-sensing ion channel activity biological_process GO:1901586 negative regulation of acid-sensing ion channel activity biological_process GO:1901587 positive regulation of acid-sensing ion channel activity biological_process GO:1901725 regulation of histone deacetylase activity biological_process GO:1901726 negative regulation of histone deacetylase activity biological_process GO:1901727 positive regulation of histone deacetylase activity biological_process GO:1902464 regulation of histone H3-K27 trimethylation biological_process GO:1902465 negative regulation of histone H3-K27 trimethylation biological_process GO:1902466 positive regulation of histone H3-K27 trimethylation biological_process GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process biological_process GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process biological_process GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process biological_process GO:1903584 regulation of histone deubiquitination biological_process GO:1903585 negative regulation of histone deubiquitination biological_process GO:1903586 positive regulation of histone deubiquitination biological_process GO:1903649 regulation of cytoplasmic transport biological_process GO:1903650 negative regulation of cytoplasmic transport biological_process GO:1903651 positive regulation of cytoplasmic transport biological_process GO:1904379 protein localization to cytosolic proteasome complex involved in ERAD pathway biological_process GO:1905427 intracellular signal transduction involved in positive regulation of cell growth biological_process GO:1990210 positive regulation by symbiont of indole acetic acid levels in host biological_process GO:1990211 positive regulation by symbiont of jasmonic acid levels in host biological_process GO:1990212 positive regulation by symbiont of ethylene levels in host biological_process GO:1990213 negative regulation by symbiont of salicylic acid levels in host biological_process GO:1990218 positive regulation by symbiont of abscisic acid levels in host biological_process GO:1990223 positive regulation by symbiont of cytokinin levels in host biological_process GO:1990258 histone glutamine methylation biological_process GO:1990619 histone H3-K9 deacetylation biological_process GO:1990678 histone H4-K16 deacetylation biological_process GO:1990679 histone H4-K12 deacetylation biological_process GO:2000615 regulation of histone H3-K9 acetylation biological_process GO:2000616 negative regulation of histone H3-K9 acetylation biological_process GO:2000617 positive regulation of histone H3-K9 acetylation biological_process GO:2000620 positive regulation of histone H4-K16 acetylation biological_process GO:2001166 regulation of histone H2B ubiquitination biological_process GO:2001168 positive regulation of histone H2B ubiquitination biological_process GO:2001173 regulation of histone H2B conserved C-terminal lysine ubiquitination molecular_function GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity molecular_function GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity molecular_function GO:0016290 palmitoyl-CoA hydrolase activity molecular_function GO:0018657 toluene 3-monooxygenase activity molecular_function GO:0030580 quinone cofactor methyltransferase activity molecular_function GO:0038058 TNFSF11 receptor activity molecular_function GO:0043333 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity molecular_function GO:0043334 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function GO:0043428 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function GO:0043429 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function GO:0043430 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function GO:0043734 DNA-N1-methyladenine dioxygenase activity molecular_function GO:0043820 propionyl-CoA dehydrogenase activity molecular_function GO:0043826 sulfur oxygenase reductase activity molecular_function GO:0043841 (S)-lactate 2-kinase activity molecular_function GO:0044466 glutaryl-CoA hydrolase activity molecular_function GO:0044595 decaprenyldihydroxybenzoate methyltransferase activity molecular_function GO:0044596 3-demethylubiquinol-10 3-O-methyltransferase activity molecular_function GO:0044736 acid-sensing ion channel activity molecular_function GO:0047379 ADP-dependent short-chain-acyl-CoA hydrolase activity molecular_function GO:0047380 ADP-dependent medium-chain-acyl-CoA hydrolase activity molecular_function GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity molecular_function GO:0047410 N-formylmethionylaminoacyl-tRNA deformylase activity molecular_function GO:0047702 beta-lysine 5,6-aminomutase activity molecular_function GO:0047901 formyl-CoA hydrolase activity molecular_function GO:0050245 quercitrinase activity molecular_function GO:0050562 lysine-tRNA(Pyl) ligase activity molecular_function GO:0052859 glucan endo-1,4-beta-glucosidase activity molecular_function GO:0061543 3-demethylubiquinol-6 3-O-methyltransferase activity molecular_function GO:0061810 NAD glycohydrolase activity molecular_function GO:0061811 ADP-ribosyl cyclase activity molecular_function GO:0061812 cyclic ADP-ribose hydrolase molecular_function GO:0099119 3-demethylubiquinol-8 3-O-methyltransferase activity molecular_function GO:0102030 dTDP-L-rhamnose synthetase activity molecular_function GO:0102040 fumarate reductase (menaquinone) molecular_function GO:0102053 (-)-jasmonoyl-isoleucine synthetase activity molecular_function GO:0102057 jasmonoyl-valine synthetase activity molecular_function GO:0102058 jasmonoyl-leucine synthetase activity molecular_function GO:0102184 cycloartenol 4alpha-methyl oxidase activity molecular_function GO:0102185 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity molecular_function GO:0102186 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity molecular_function GO:0102188 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity molecular_function GO:0102190 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity molecular_function GO:0102278 N,N'-diacetylchitobiose synthase activity molecular_function GO:0102393 decanoyl-[acp] 2-dehydrogenase activity molecular_function GO:0102783 beta-carotene oxygenase activity molecular_function GO:0102991 myristoyl-CoA hydrolase activity molecular_function GO:0106314 nitrite reductase NADPH activity molecular_function GO:0140061 5-hydroxymethylcytosine dioxygenase activity molecular_function GO:0140062 5-formylcytosine dioxygenase activity molecular_function GO:1990887 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity cellular_component GO:0097344 Rix1 complex 0 MERGED TERMS CHANGES 334 META CHANGES biological_process GO:0000038 very long-chain fatty acid metabolic process definition "The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd] WAS "The chemical reactions and pathways involving a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons." [GOC:hjd] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0000196 cell wall integrity MAPK cascade definition "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:15944456, PMID:17604854, PMID:26945038, PMID:9561267] WAS "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:17604854, PMID:9561267] biological_process GO:0000910 cytokinesis subsets gocheck_do_not_manually_annotate;goslim_candida;goslim_generic;goslim_prokaryote;goslim_yeast WAS gocheck_do_not_manually_annotate;goslim_candida;goslim_generic;goslim_yeast;prokaryote_subset biological_process GO:0001579 medium-chain fatty acid transport definition "The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:ai] WAS "The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0001676 long-chain fatty acid metabolic process definition "The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp] WAS "The chemical reactions and pathways involving a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:ajp] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0005975 carbohydrate metabolic process subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006091 generation of precursor metabolites and energy subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006260 DNA replication subsets goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006281 DNA repair subsets goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006310 DNA recombination subsets goslim_drosophila;goslim_generic;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_drosophila;goslim_generic;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006351 DNA-templated transcription subsets goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0006355 regulation of DNA-templated transcription subsets goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_drosophila;goslim_generic;prokaryote_subset biological_process GO:0006412 translation subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_metagenomics;goslim_pir;goslim_plant;prokaryote_subset biological_process GO:0006457 protein folding subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006486 protein glycosylation subsets goslim_generic;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_generic;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006520 amino acid metabolic process subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006575 cellular modified amino acid metabolic process subsets goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_drosophila;goslim_generic;prokaryote_subset biological_process GO:0006629 lipid metabolic process subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0006790 sulfur compound metabolic process subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0006810 transport subsets gocheck_do_not_annotate;goslim_candida;goslim_chembl;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote WAS gocheck_do_not_annotate;goslim_candida;goslim_chembl;goslim_metagenomics;goslim_pir;goslim_plant;prokaryote_subset biological_process GO:0006886 intracellular protein transport subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset biological_process GO:0007005 mitochondrion organization synonyms "mitochondria organization" EXACT [GOC:mah];"mitochondrial biogenesis" EXACT [];"mitochondrial organization" EXACT [];"mitochondrion biogenesis" EXACT [];"mitochondrion organisation" EXACT [GOC:mah];"mitochondrion organization and biogenesis" RELATED [] WAS "mitochondria organization" EXACT [GOC:mah];"mitochondrion organisation" EXACT [GOC:mah];"mitochondrion organization and biogenesis" RELATED [] biological_process GO:0007010 cytoskeleton organization subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_yeast;prokaryote_subset biological_process GO:0007059 chromosome segregation subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_yeast;prokaryote_subset biological_process GO:0007155 cell adhesion subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0007163 establishment or maintenance of cell polarity subsets goslim_drosophila;goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_drosophila;goslim_generic;goslim_pombe;prokaryote_subset biological_process GO:0007224 smoothened signaling pathway definition "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520] WAS "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] biological_process GO:0007249 canonical NF-kappaB signal transduction definition "An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] WAS "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217] synonyms "canonical NF-kappaB signaling cascade" EXACT [GOC:bf];"I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling];"I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling];"I-kappaB kinase/NF-kappaB signaling" EXACT [];"NF-kappaB cascade" BROAD [];"p50-dependent NF-kappaB signaling" RELATED [PMID:18292232] WAS "canonical NF-kappaB signaling cascade" EXACT [GOC:bf];"I-kappaB kinase/NF-kappaB cascade" EXACT [GOC:signaling];"I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling];"I-kappaB kinase/NF-kappaB signaling" EXACT [];"NF-kappaB cascade" EXACT [];"p50-dependent NF-kappaB signaling" RELATED [PMID:18292232] biological_process GO:0007263 nitric oxide mediated signal transduction definition "An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190] WAS "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190] biological_process GO:0007264 small GTPase-mediated signal transduction name small GTPase-mediated signal transduction WAS small GTPase mediated signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah] WAS "The series of molecular signals in which a small monomeric GTPase relays a signal." [GOC:mah] synonyms "Ras family protein signal transduction" NARROW [];"small GTPase mediated signal transduction" EXACT [] WAS "small GTPase-mediated signal transduction" EXACT [] biological_process GO:0007265 Ras protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf] WAS "The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] biological_process GO:0007266 Rho protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf] WAS "The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] biological_process GO:0009627 systemic acquired resistance definition "The salicylic acid-mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, Wikipedia:Systemic_acquired_resistance] WAS "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:0521436125] biological_process GO:0009682 induced systemic resistance definition "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273, PMID:15233292, PMID:23386685] WAS "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] biological_process GO:0009695 jasmonic acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [PMID:33821356] WAS "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] biological_process GO:0010746 regulation of long-chain fatty acid import across plasma membrane definition "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:BHF, GOC:dph, GOC:tb] WAS "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0010747 positive regulation of long-chain fatty acid import across plasma membrane definition "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:BHF, GOC:dph, GOC:tb] WAS "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0012501 programmed cell death subsets goslim_agr;goslim_chembl;goslim_drosophila;goslim_generic;goslim_mouse;goslim_plant;goslim_prokaryote WAS goslim_agr;goslim_chembl;goslim_drosophila;goslim_generic;goslim_mouse;goslim_plant;prokaryote_subset biological_process GO:0015909 long-chain fatty acid transport definition "The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai] WAS "The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0015910 long-chain fatty acid import into peroxisome definition "The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai] WAS "The directed movement of a long-chain fatty acid into a peroxisome. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0015911 long-chain fatty acid import across plasma membrane definition "The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ai] WAS "The directed movement of a long-chain fatty acid from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0015912 short-chain fatty acid transport definition "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai] WAS "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0015913 short-chain fatty acid transmembrane transport definition "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:ai] WAS "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons." [GOC:ai] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0015979 photosynthesis subsets goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;prokaryote_subset biological_process GO:0016070 RNA metabolic process subsets goslim_agr;goslim_candida;goslim_metagenomics;goslim_pir;goslim_prokaryote WAS goslim_agr;goslim_candida;goslim_metagenomics;goslim_pir;prokaryote_subset biological_process GO:0016071 mRNA metabolic process subsets goslim_drosophila;goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_drosophila;goslim_generic;goslim_pombe;prokaryote_subset biological_process GO:0016601 Rac protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Rac subfamily relays a signal." [GOC:bf] WAS "The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] biological_process GO:0019042 viral latency definition "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl, VZ:3970] WAS "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl] biological_process GO:0019069 viral capsid assembly definition "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, PMID:22615368] WAS "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, UniProtKB-KW:KW-0118] biological_process GO:0019418 sulfide oxidation definition "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] WAS "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] biological_process GO:0019420 dissimilatory sulfate reduction definition "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [PMID:25400653, PMID:26680199] WAS "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] biological_process GO:0019626 short-chain fatty acid catabolic process definition "The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [ISBN:0198506732] WAS "The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of less than 6 carbons." [ISBN:0198506732] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0019933 cAMP-mediated signaling definition "An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling] WAS "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] biological_process GO:0019934 cGMP-mediated signaling definition "An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling] WAS "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] biological_process GO:0019935 cyclic-nucleotide-mediated signaling definition "An intracellular signaling cassette that starts with production or release of the cyclic nucleotide, and ends with the activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling] WAS "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] biological_process GO:0023052 signaling subsets goslim_agr;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0030030 cell projection organization subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0030163 protein catabolic process subsets goslim_candida;goslim_drosophila;goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_candida;goslim_drosophila;goslim_generic;goslim_pombe;prokaryote_subset biological_process GO:0030643 intracellular phosphate ion homeostasis synonyms "cellular phosphate ion homeostasis" EXACT [];"intracellular phosphate homeostasis" BROAD [];"intracellular Pi homeostasis" EXACT [] WAS "cellular phosphate ion homeostasis" EXACT [] biological_process GO:0030682 symbiont-mediated perturbation of host defenses name symbiont-mediated perturbation of host defenses WAS perturbation of host defenses by symbiont definition "A process in which a symbiont alters or subverts the normal execution of a host organism's defense response. The host defense response is mounted by the host in response to the presence of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] WAS "A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph];"avoidance of defenses of other organism involved in symbiotic interaction" NARROW [];"avoidance of host defences" NARROW [];"avoidance of host defenses" NARROW [];"evasion of host defence response" NARROW [];"evasion of other organism defence response" NARROW [];"evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph];"evasion or tolerance of defense response of other organism involved in symbiotic interaction" BROAD [];"evasion or tolerance of defenses of other organism" RELATED [];"evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph];"evasion or tolerance of defenses of other organism involved in symbiotic interaction" RELATED [];"evasion or tolerance of host defense response" NARROW [];"evasion or tolerance of host defenses" RELATED [];"mitigation of host defenses by symbiont" EXACT [];"perturbation of host defenses by symbiont" EXACT [] WAS "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph];"avoidance of defenses of other organism involved in symbiotic interaction" NARROW [];"avoidance of host defences" NARROW [];"avoidance of host defenses" NARROW [];"evasion of host defence response" NARROW [];"evasion of other organism defence response" NARROW [];"evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph];"evasion or tolerance of defense response of other organism involved in symbiotic interaction" BROAD [];"evasion or tolerance of defenses of other organism" RELATED [];"evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph];"evasion or tolerance of defenses of other organism involved in symbiotic interaction" RELATED [];"evasion or tolerance of host defense response" NARROW [];"evasion or tolerance of host defenses" RELATED [];"mitigation of host defenses by symbiont" EXACT [] biological_process GO:0030968 endoplasmic reticulum unfolded protein response comment Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. WAS Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. biological_process GO:0031291 Ran protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Ran subfamily relays a signal." [GOC:mah] WAS "The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] biological_process GO:0032011 ARF protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the ARF subfamily relays a signal." [GOC:mah] WAS "The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] biological_process GO:0032359 provirus excision definition "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg, VZ:3969] WAS "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] biological_process GO:0032482 Rab protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah] WAS "The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] biological_process GO:0032484 Ral protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the RaI subfamily relays a signal." [GOC:mah] WAS "The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] biological_process GO:0032486 Rap protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal." [GOC:mah] WAS "The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] biological_process GO:0032488 Cdc42 protein signal transduction definition "An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478] WAS "The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah, PMID:18558478] biological_process GO:0033013 tetrapyrrole metabolic process subsets goslim_pombe;goslim_prokaryote WAS goslim_pombe;prokaryote_subset biological_process GO:0034050 symbiont-induced defense-related programmed cell death name symbiont-induced defense-related programmed cell death WAS programmed cell death induced by symbiont comment Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'. WAS Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'positive regulation by symbiont of host programmed cell death ; GO:0052042'. synonyms "host programmed cell death induced by symbiont" EXACT [];"programmed cell death induced by symbiont" EXACT [] WAS "'host programmed cell death induced by symbiont'" EXACT [] biological_process GO:0034080 CENP-A containing chromatin assembly definition "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390] WAS "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403] biological_process GO:0035329 hippo signaling definition "An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846] WAS "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423] biological_process GO:0035336 long-chain fatty-acyl-CoA metabolic process definition "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732] WAS "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process definition "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732] WAS "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0035556 intracellular signal transduction synonyms "intracellular signal transduction pathway" NARROW [];"intracellular signaling cascade" RELATED [GOC:signaling];"intracellular signaling pathway" RELATED [];"signal transmission via intracellular cascade" NARROW [] WAS "intracellular protein kinase cascade" NARROW [GOC:signaling];"intracellular signal transduction pathway" NARROW [];"intracellular signaling cascade" RELATED [GOC:signaling];"intracellular signaling chain" EXACT [ISBN:3527303782];"intracellular signaling pathway" RELATED [];"protein kinase cascade" NARROW [GOC:signaling];"signal transduction via intracellular signaling cascade" RELATED [];"signal transmission via intracellular cascade" NARROW [] biological_process GO:0036111 very long-chain fatty-acyl-CoA metabolic process definition "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:pm] WAS "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0036112 medium-chain fatty-acyl-CoA metabolic process definition "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:pm] WAS "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons." [GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0036113 very long-chain fatty-acyl-CoA catabolic process definition "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a very long-chain fatty-acyl group. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:pm] WAS "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0036114 medium-chain fatty-acyl-CoA catabolic process definition "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [GOC:pm] WAS "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with an aliphatic tail of 6 to 12 carbons." [GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0036116 long-chain fatty-acyl-CoA catabolic process definition "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm] WAS "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0036211 protein modification process subsets goslim_candida;goslim_chembl;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_candida;goslim_chembl;goslim_pir;goslim_plant;prokaryote_subset biological_process GO:0036386 bacterial nucleoid packaging subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0038060 nitric oxide-cGMP-mediated signaling pathway definition "An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632] WAS "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632] biological_process GO:0038061 non-canonical NF-kappaB signal transduction definition "An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] WAS "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882, PMID:34659217] synonyms "NF-kappaB cascade" BROAD [];"NIK-IKK kinase cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK-IKK signaling pathway" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK-IKK-alpha cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK/NF-kappaB cascade" EXACT [GOC:signaling];"NIK/NF-kappaB signal transduction" EXACT [GOC:signaling];"NIK/NF-kappaB signaling" EXACT [];"non-canonical NF-KB signaling" EXACT [PMID:21173796];"noncanonical NF-kappaB signaling" EXACT [PMID:20501935];"noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [PMID:20501935];"p52-dependent NF-kappaB signaling" NARROW [PMID:18292232] WAS "NIK-IKK kinase cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK-IKK signaling pathway" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK-IKK-alpha cascade" EXACT [GOC:rph, PMID:10094049, PMID:10581243, PMID:9244310];"NIK/NF-kappaB cascade" EXACT [GOC:signaling];"NIK/NF-kappaB signal transduction" EXACT [GOC:signaling];"NIK/NF-kappaB signaling" EXACT [];"non-canonical NF-KB signaling" EXACT [PMID:21173796];"noncanonical NF-kappaB signaling" EXACT [PMID:20501935];"noncanonical nuclear factor kappaB (NF-kappaB) pathway" EXACT [PMID:20501935];"p52-dependent NF-kappaB signaling" NARROW [PMID:18292232] biological_process GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway name symbiont-mediated suppression of host type I interferon-mediated signaling pathway WAS suppression by virus of host type I interferon-mediated signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, PMID:19802576, PMID:26712804, PMID:32464097, PMID:32733001, PMID:33097660] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, PMID:19802576, PMID:26712804, PMID:32464097, PMID:32733001, PMID:33097660] synonyms "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114];"negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf];"suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf];"suppression by virus of host type I interferon-mediated signaling pathway" NARROW [];"suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf] WAS "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114];"negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf];"suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf];"suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf] biological_process GO:0039514 symbiont-mediated suppression of host JAK-STAT cascade name symbiont-mediated suppression of host JAK-STAT cascade WAS disruption by virus of host JAK-STAT cascade definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:20624917, PMID:22919663, PMID:27437422, PMID:29924996, PMID:31413201] WAS "A process in which a virus interferes with, inhibits or stops the JAK-STAT signal cascade in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp] synonyms "disruption by virus of host JAK-STAT cascade" NARROW [];"down-regulation by virus of host JAK-STAT cascade" NARROW [GOC:bf];"downregulation by virus of host JAK-STAT cascade" NARROW [GOC:bf];"inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf];"negative regulation by virus of host JAK-STAT cascade" NARROW [GOC:bf];"suppression by virus of host JAK-STAT cascade" NARROW [] WAS "down-regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf];"downregulation by virus of host JAK-STAT cascade" EXACT [GOC:bf];"inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf];"negative regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf];"suppression by virus of host JAK-STAT cascade" EXACT [] biological_process GO:0039527 symbiont-mediated suppression of host TRAF-mediated signal transduction name symbiont-mediated suppression of host TRAF-mediated signal transduction WAS disruption by virus of host TRAF-mediated signal transduction definition "A process in which a symbiont interferes with, inhibits or disrupts a TRAF-mediated signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:20335533, PMID:27387501, PMID:28522607, PMID:31311877, PMID:33372174] WAS "A process in which a virus interferes with, inhibits or stops TRAF-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:sp, PMID:20335533, PMID:27387501, PMID:28522607, PMID:31311877, PMID:33372174] comment N/A WAS This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonyms "disruption by virus of host TRAF-mediated signal transduction" NARROW [];"inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf];"inhibition of host TRAFs by virus" NARROW [];"negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf];"suppression by virus of host TRAF activity" EXACT [];"suppression by virus of host TRAF-mediated signal transduction" EXACT [];"suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] WAS "inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf];"inhibition of host TRAFs by virus" NARROW [];"negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf];"suppression by virus of host TRAF activity" EXACT [];"suppression by virus of host TRAF-mediated signal transduction" EXACT [];"suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] biological_process GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway name symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the host viral-induced cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] synonyms "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf];"suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf];"suppression by virus of host RLR signaling pathway" RELATED [GOC:bf];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway" NARROW [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] WAS "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf];"suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf];"suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf];"suppression by virus of host RLR signaling pathway" RELATED [GOC:bf];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] biological_process GO:0039540 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19454348, PMID:26138103] WAS "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19454348, PMID:26138103] synonyms "inhibition by virus of host DDX58 activity" RELATED [GOC:sp];"inhibition by virus of host RIG-I" RELATED [];"inhibition by virus of host RIG-I signaling" RELATED [];"inhibition of host DDX58/RIG-I by virus" EXACT [];"suppression by virus of host DDX58 signaling pathway" RELATED [];"suppression by virus of host RIG-I activity" RELATED [];"suppression by virus of host RIG-I signaling pathway" RELATED [];"suppression by virus of host RIG-I signalling pathway" EXACT [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity" NARROW [] WAS "inhibition by virus of host DDX58 activity" RELATED [GOC:sp];"inhibition by virus of host RIG-I" RELATED [];"inhibition by virus of host RIG-I signaling" RELATED [];"inhibition of host DDX58/RIG-I by virus" EXACT [];"suppression by virus of host DDX58 signaling pathway" RELATED [];"suppression by virus of host RIG-I activity" RELATED [];"suppression by virus of host RIG-I signaling pathway" RELATED [];"suppression by virus of host RIG-I signalling pathway" EXACT [] biological_process GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [PMID:17438296, PMID:22674996] WAS "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [PMID:17438296, PMID:22674996] synonyms "inhibition of host MAVS by virus" RELATED [];"suppression by virus of host MAVS activity" RELATED [];"suppression by virus of host mitochondrial antiviral-signaling protein" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity" NARROW [] WAS "inhibition of host MAVS by virus" RELATED [];"suppression by virus of host MAVS activity" RELATED [];"suppression by virus of host mitochondrial antiviral-signaling protein" RELATED [] biological_process GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562] WAS "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562] synonyms "inhibition of host IRF3 by virus" RELATED [];"inhibition of IRF3-dependent antiviral response" RELATED [PMID:19125153];"suppression by virus of host interferon regulatory factor 3" RELATED [];"suppression by virus of host IRF3 activity" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity" NARROW [] WAS "inhibition of host IRF3 by virus" RELATED [];"inhibition of IRF3-dependent antiviral response" RELATED [PMID:19125153];"suppression by virus of host interferon regulatory factor 3" RELATED [];"suppression by virus of host IRF3 activity" RELATED [] biological_process GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19019954, PMID:33727702] WAS "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19019954, PMID:33727702] synonyms "inhibition by virus of host MDA-5 signaling" RELATED [];"inhibition of host IFIH1/MDA5 by virus" RELATED [];"Inhibition of host MDA5 by virus" RELATED [];"suppression by virus of host IFIH1 signaling pathway" RELATED [];"suppression by virus of host MDA-5 activity" RELATED [];"suppression by virus of host MDA-5 signaling pathway" RELATED [];"suppression by virus of host MDA-5 signalling pathway" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity" NARROW [] WAS "inhibition by virus of host MDA-5 signaling" RELATED [];"inhibition of host IFIH1/MDA5 by virus" RELATED [];"Inhibition of host MDA5 by virus" RELATED [];"suppression by virus of host IFIH1 signaling pathway" RELATED [];"suppression by virus of host MDA-5 activity" RELATED [];"suppression by virus of host MDA-5 signaling pathway" RELATED [];"suppression by virus of host MDA-5 signalling pathway" RELATED [] biological_process GO:0039557 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:11943871, PMID:16014964, PMID:19557165] WAS "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:11943871, PMID:16014964, PMID:19557165] synonyms "inhibition of host interferon regulatory factor-7 by virus" RELATED [];"inhibition of host IRF7 by virus" RELATED [];"suppression by virus of host interferon regulatory factor 7 activity" RELATED [];"suppression by virus of host IRF7 activity" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity" NARROW [] WAS "inhibition of host interferon regulatory factor-7 by virus" RELATED [];"inhibition of host IRF7 by virus" RELATED [];"suppression by virus of host interferon regulatory factor 7 activity" RELATED [];"suppression by virus of host IRF7 activity" RELATED [] biological_process GO:0039560 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity WAS disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. For example, viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [PMID:10388655, PMID:19109390] WAS "Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [PMID:10388655, PMID:19109390] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonyms "disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" NARROW [];"inhibition of host interferon regulatory factor-9 by virus" NARROW [GOC:bf];"inhibition of host IRF9 by virus" NARROW [];"suppression by virus of host interferon regulatory factor 9 activity" NARROW [];"suppression by virus of host IRF9 activity" NARROW [];"suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" NARROW [] WAS "inhibition of host interferon regulatory factor-9 by virus" EXACT [GOC:bf];"inhibition of host IRF9 by virus" EXACT [];"suppression by virus of host interferon regulatory factor 9 activity" RELATED [];"suppression by virus of host IRF9 activity" RELATED [];"suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity" EXACT [] biological_process GO:0039562 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity WAS disruption by virus of host JAK-STAT cascade via inhibition of STAT activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf] WAS "Any process in which a virus interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonyms "disruption by virus of host JAK-STAT cascade via inhibition of STAT activity" NARROW [];"inhibition by virus of host STAT activity" NARROW [GOC:bf];"suppression by virus of host JAK-STAT cascade via inhibition of STAT activity" EXACT [];"suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf];"suppression by virus of host STAT activity" EXACT [] WAS "inhibition by virus of host STAT activity" NARROW [GOC:bf];"suppression by virus of host JAK-STAT cascade via inhibition of STAT activity" EXACT [];"suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf];"suppression by virus of host STAT activity" EXACT [] biological_process GO:0039563 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity WAS disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1)." [PMID:32699158] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1)." [PMID:32699158] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonyms "disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity" NARROW [];"inhibition by virus of host STAT1 activity" NARROW [GOC:bf];"inhibition of host STAT1 by virus" NARROW [];"suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity" NARROW [];"suppression by virus of host STAT1 activity" NARROW [] WAS "inhibition by virus of host STAT1 activity" NARROW [GOC:bf];"inhibition of host STAT1 by virus" NARROW [];"suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity" EXACT [];"suppression by virus of host STAT1 activity" RELATED [] biological_process GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity WAS disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2)." [PMID:32699158] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2)." [PMID:32699158] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS N/A synonyms "disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity" NARROW [];"inhibition by virus of host STAT2 activity" NARROW [GOC:bf];"inhibition of host STAT2 by virus" NARROW [];"suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity" NARROW [];"suppression by virus of host STAT2 activity" NARROW [] WAS "inhibition by virus of host STAT2 activity" RELATED [GOC:bf];"inhibition of host STAT2 by virus" RELATED [];"suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity" EXACT [];"suppression by virus of host STAT2 activity" RELATED [] biological_process GO:0039574 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity WAS disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase involved in numerous cytokines and interferons signaling pathways and transmits the cytokine signal by phosphorylating receptor subunits." [PMID:16987978, PMID:19085955] WAS "Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits." [PMID:16987978, PMID:19085955] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS N/A synonyms "disruption by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW [];"suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" NARROW [];"suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" NARROW [];"suppression by virus of host TYK2 activity" NARROW [] WAS "suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity" EXACT [];"suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" EXACT [];"suppression by virus of host TYK2 activity" RELATED [] biological_process GO:0039576 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity name symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity WAS disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity definition "A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host JAK1 (Janus Kinase 1)." [PMID:16188985] WAS "Any process in which interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1)." [PMID:16188985] comment This term is for annotation of symbiont proteins that counteract the host innate immune response. WAS N/A synonyms "disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity" NARROW [];"inhibition of host JAK activity by virus" NARROW [GOC:bf];"negative regulation by virus of host JAK" NARROW [GOC:bf];"negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf];"suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity" NARROW [];"suppression by virus of host JAK1 activity" NARROW [];"suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW [];"viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] WAS "inhibition of host JAK activity by virus" NARROW [GOC:bf];"negative regulation by virus of host JAK" EXACT [GOC:bf];"negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf];"suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity" EXACT [];"suppression by virus of host JAK1 activity" EXACT [];"suppression by virus of host janus kinase 1 activity" EXACT [PR:000009196];"suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW [];"viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] biological_process GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling name symbiont-mediated suppression of host PKR/eIFalpha signaling WAS suppression by virus of host PKR signaling definition "A process in which a symbiont interferes with, inhibits or disrupts a host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response." [PMID:15207627] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response." [PMID:15207627] synonyms "suppression by virus of host EIF2AK2 activity" NARROW [];"suppression by virus of host PKR activity" NARROW [];"suppression by virus of host PKR signaling" NARROW [] WAS "suppression by virus of host EIF2AK2 activity" NARROW [];"suppression by virus of host PKR activity" NARROW [] biological_process GO:0039585 PKR/eIFalpha signaling name PKR/eIFalpha signaling WAS PKR-mediated signaling definition "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with inhibition of translation." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576] WAS "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK2), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576] biological_process GO:0039592 symbiont-mediated arrest of host cell cycle during G2/M transition name symbiont-mediated arrest of host cell cycle during G2/M transition WAS perturbation by virus of G2/M transition of host mitotic cell cycle definition "A process in which a symbiont interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase. The arrest in G2/M allows some viruses to replicate their genome before cells enter mitosis. Alternatively, it can inhibit the antiviral immune response by preventing the clonal expansion of infected lymphocytes." [PMID:10946289, PMID:12208959, PMID:9882364, VZ:876] WAS "A process in which a virus interferes with the progression of the host mitotic cell cycle from G2 phase to M phase, leading to arrest in G2 phase." [UniProtKB-KW:KW-1079, VZ:876] synonyms "host G2/M cell cycle arrest by virus" NARROW [];"perturbation by virus of G2/M transition of host mitotic cell cycle" NARROW [];"suppression by virus of G2/M transition of host mitotic cell cycle" NARROW [] WAS "host G2/M cell cycle arrest by virus" EXACT [UniProtKB-KW:KW-1079];"suppression by virus of G2/M transition of host mitotic cell cycle" RELATED [] biological_process GO:0039593 symbiont-mediated perturbation of host exit from mitosis name symbiont-mediated perturbation of host exit from mitosis WAS peturbation by virus of host exit from mitosis definition "A process in which a virus interferes with the host cell completing the M phase of the cell cycle." [VZ:877] WAS "A process in which a virus interferes with the host cell completing the M phase of the cell cycle." [UniProtKB-KW:KW-1098, VZ:877] synonyms "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877];"perturbation by virus of host exit from mitosis" NARROW [];"suppression by virus of host exit from mitosis" RELATED [] WAS "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877];"suppression by virus of host exit from mitosis" RELATED [] biological_process GO:0039645 symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint name symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint WAS perturbation by virus of host G1/S transition checkpoint definition "A process in which a symbiont interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24501404, VZ:880] WAS "A process in which a virus interferes with the normal execution of the host cell G1/S transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction." [UniProtKB-KW:KW-1078] synonyms "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [VZ:880];"modulation by virus of host G1/S transition checkpoint" RELATED [];"perturbation by virus of host G1/S transition checkpoint" NARROW [] WAS "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1078, VZ:880];"modulation by virus of host G1/S transition checkpoint" RELATED [] biological_process GO:0039646 symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint name symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint WAS perturbation by virus of host G0/G1 transition checkpoint definition "A process in which a symbiont interferes with the normal execution of the host cell G0/G1 transition checkpoint. The host is defined as the larger of the organisms involved in a symbiotic interaction. Some viruses benefit from keeping cells in resting state (G0), while others favor entry through G1 and subsequent cell division to replicate more efficiently." [VZ:880] WAS "A process in which a virus interferes with the normal execution of the host cell G0/G1 transition checkpoint." [UniProtKB-KW:KW-1077] synonyms "G0/G1 host cell cycle checkpoint dysregulation by virus" NARROW [UniProtKB-KW:KW-1077, VZ:881];"modulation by virus of host G0/G1 transition checkpoint" NARROW [];"perturbation by virus of host G0/G1 transition checkpoint" NARROW [] WAS "G0/G1 host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1077, VZ:881];"modulation by virus of host G0/G1 transition checkpoint" RELATED [] biological_process GO:0039648 symbiont-mediated perturbation of host protein ubiquitination name symbiont-mediated perturbation of host protein ubiquitination WAS modulation by symbiont of host protein ubiquitination definition "A process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism." [PMID:25166298, PMID:26483404, PMID:26712804] WAS "Any process by which a symbiont increases or decreases ubiquitination of target proteins of a host organism." [PMID:25166298, PMID:26483404, PMID:26712804] synonyms "modulation by symbiont of host protein ubiquitination" EXACT [];"modulation of host ubiquitin pathway by virus" NARROW [] WAS "modulation of host ubiquitin pathway by virus" NARROW [] biological_process GO:0039678 symbiont genome ejection through host cell envelope name symbiont genome ejection through host cell envelope WAS viral genome ejection through host cell envelope definition "Entry of a symbiont's genome into the host cell through the host cell envelope. Occurs in non-enveloped prokaryotic viruses. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, PMID:31663016, VZ:986] WAS "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171] comment N/A WAS When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'. synonyms "phage genome ejection" NARROW [PMID:23385786];"viral genome ejection through host cell envelope" RELATED [];"viral genome injection through bacterial membranes" NARROW [VZ:986] WAS "phage genome ejection" NARROW [PMID:23385786];"viral genome injection through bacterial membranes" NARROW [UniProtKB-KW:KW-1171] biological_process GO:0039699 evasion of mRNA degradation by host via mRNA cap methylation name evasion of mRNA degradation by host via mRNA cap methylation WAS viral mRNA cap methylation definition "An innate immune response evasion mechanism in which a symbiont methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. This mechanism of immune evasion is used by viruses." [PMID:35215972] WAS "An innate immune response evasion mechanism in which a virus methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs." [PMID:35215972] synonyms "IFIT mRNA restriction evasion by virus" EXACT [PMID:35215972];"viral mRNA cap methylation" RELATED [] WAS "IFIT mRNA restriction evasion by virus" EXACT [PMID:35215972] biological_process GO:0039722 symbiont-mediated suppression of host toll-like receptor signaling pathway name symbiont-mediated suppression of host toll-like receptor signaling pathway WAS suppression by virus of host toll-like receptor signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a toll-like receptor signaling pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15944308, PMID:17299722, PMID:18327267] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism." [UniProtKB-KW:KW-1225] synonyms "inhibition of host TLR pathway by virus" NARROW [];"suppression by virus of host TLR signaling pathway" NARROW [];"suppression by virus of host toll-like receptor signaling pathway" NARROW [] WAS "inhibition of host TLR pathway by virus" EXACT [UniProtKB-KW:KW-1125];"suppression by virus of host TLR signaling pathway" EXACT [] biological_process GO:0039723 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity definition "Any process in which a symbiont stops, prevents, or reduces a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1." [PMID:22171259, PMID:34084167] WAS "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1." [PMID:22171259, PMID:34084167] synonyms "inhibition of host TBK1 by virus" RELATED [];"suppression by virus of host TBK1 activity" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity" NARROW [] WAS "inhibition of host TBK1 by virus" RELATED [];"suppression by virus of host TBK1 activity" RELATED [] biological_process GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity name symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity WAS suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity definition "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PMID:19153231, PMID:22532683, PMID:24173023] WAS "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PMID:19153231, PMID:22532683, PMID:24173023] synonyms "inhibition of host IKBKE by virus" RELATED [];"suppression by virus of host IKBKE activity" RELATED [];"suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity" NARROW [] WAS "inhibition of host IKBKE by virus" RELATED [];"suppression by virus of host IKBKE activity" RELATED [] biological_process GO:0040033 sRNA-mediated post-transcriptional gene silencing subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0042178 xenobiotic catabolic process subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0042254 ribosome biogenesis subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0042758 long-chain fatty acid catabolic process definition "The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [PMID:20043225] WAS "The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons." [PMID:20043225] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0042759 long-chain fatty acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [PMID:18390550] WAS "The chemical reactions and pathways resulting in the formation of a long-chain fatty acid, a fatty acid with an aliphatic tail of 13 to 21 carbons." [PMID:18390550] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0042760 very long-chain fatty acid catabolic process definition "The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868] WAS "The chemical reactions and pathways resulting in the breakdown of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons." [PMID:7744868] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0042761 very long-chain fatty acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868] WAS "The chemical reactions and pathways resulting in the formation of a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons." [PMID:7744868] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0042784 symbiont-mediated suppression of host complement activation name symbiont-mediated suppression of host complement activation WAS evasion of host immune response via modulation of host complement system definition "A process by which a symbiont inhibits or disrupts the normal execution of the activation of complement in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20194595, PMID:21191012, PMID:25830295, PMID:7745740] WAS "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] synonyms "active evasion of host immune response via regulation of host complement system" RELATED [];"active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction" BROAD [];"active immune evasion via modulation of host complement system" EXACT [];"active immune evasion via regulation of host complement system" EXACT [];"evasion of host immune response via modulation of host complement system" EXACT [];"evasion of host immune response via regulation of host complement system" EXACT [];"suppression of complement activation by another organism" BROAD [] WAS "active evasion of host immune response via regulation of host complement system" RELATED [];"active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction" BROAD [];"active immune evasion via modulation of host complement system" EXACT [];"active immune evasion via regulation of host complement system" EXACT [];"evasion of host immune response via regulation of host complement system" EXACT [] biological_process GO:0043062 extracellular structure organization subsets goslim_pir;goslim_prokaryote WAS goslim_pir;prokaryote_subset biological_process GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction definition "An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway." [PMID:20517722, PMID:22952397] WAS "An intracellular signal transduction pathway that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway." [PMID:20517722, PMID:22952397] biological_process GO:0044029 positive regulation of gene expression via CpG island demethylation synonyms "DNA demethylation" BROAD [];"DNA hypomethylation of CpG island" EXACT [];"hypomethylation of CpG island" EXACT [] WAS "DNA hypomethylation of CpG island" EXACT [];"hypomethylation of CpG island" EXACT [] biological_process GO:0044071 symbiont-mediated perturbation of host cell cycle progression name symbiont-mediated perturbation of host cell cycle progression WAS perturbation of host cell cycle progression synonyms "modification by symbiont of host cell cycle" EXACT [];"modulation by symbiont of host cell cycle" EXACT [];"modulation of host cell cycle by symbiont" EXACT [];"perturbation of host cell cycle progression" EXACT [];"regulation by symbiont of host cell cycle" EXACT [] WAS "modification by symbiont of host cell cycle" EXACT [];"modulation by symbiont of host cell cycle" EXACT [];"modulation of host cell cycle by symbiont" EXACT [];"regulation by symbiont of host cell cycle" EXACT [] biological_process GO:0044075 symbiont-mediated perturbation of host vacuole organization definition "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [PMID:25139904] WAS "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] biological_process GO:0044080 symbiont-mediated perturbation of host cGMP-mediated signal transduction name symbiont-mediated perturbation of host cGMP-mediated signal transduction WAS perturbation of host cGMP-mediated signal transduction synonyms "modulation by symbiont of host cGMP-mediated signal transduction" EXACT [];"modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT [];"modulation by symbiont of host cGMP-mediated signaling" EXACT [];"modulation by symbiont of host cGMP-mediated signalling" EXACT [];"modulation of host cGMP-mediated signal transduction by symbiont" EXACT [];"perturbation of host cGMP-mediated signal transduction" EXACT [];"regulation by symbiont of host cGMP-mediated signal transduction" EXACT [] WAS "modulation by symbiont of host cGMP-mediated signal transduction" EXACT [];"modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT [];"modulation by symbiont of host cGMP-mediated signaling" EXACT [];"modulation by symbiont of host cGMP-mediated signalling" EXACT [];"modulation of host cGMP-mediated signal transduction by symbiont" EXACT [];"regulation by symbiont of host cGMP-mediated signal transduction" EXACT [] biological_process GO:0044082 symbiont-mediated perturbation of host small GTPase-mediated signal transduction name symbiont-mediated perturbation of host small GTPase-mediated signal transduction WAS perturbation of host small GTPase mediated signal transduction synonyms "modulation by symbiont of host small GTPase mediated signal transduction" EXACT [];"modulation of host small GTPase mediated signal transduction by symbiont" EXACT [];"perturbation of host small GTPase mediated signal transduction" EXACT [];"regulation by symbiont of host small GTPase mediated signal transduction" EXACT [] WAS "modulation by symbiont of host small GTPase mediated signal transduction" EXACT [];"modulation of host small GTPase mediated signal transduction by symbiont" EXACT [];"regulation by symbiont of host small GTPase mediated signal transduction" EXACT [] biological_process GO:0044083 symbiont-mediated perturbation of host Rho signal transduction name symbiont-mediated perturbation of host Rho signal transduction WAS perturbation of host Rho protein signal transduction definition "A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15694861, PMID:17689917, PMID:30201700] WAS "A process in which a symbiont alters a Rho protein family-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] synonyms "modulation by symbiont of host Rho protein mediated signal transduction" EXACT [];"modulation by symbiont of host Rho protein signal transduction" EXACT [];"modulation by symbiont of host Rho protein-mediated signal transduction" EXACT [];"modulation of host Rho protein signal transduction by symbiont" EXACT [];"modulation of host Rho protein signaling by symbiont" EXACT [];"modulation of host Rho protein signalling by symbiont" EXACT [];"perturbation of host Rho protein signal transduction" EXACT [];"regulation by symbiont of host Rho protein signal transduction" EXACT [];"symbiont-mediated perturbation of host Rho protein signal transduction" EXACT [] WAS "modulation by symbiont of host Rho protein mediated signal transduction" EXACT [];"modulation by symbiont of host Rho protein signal transduction" EXACT [];"modulation by symbiont of host Rho protein-mediated signal transduction" EXACT [];"modulation of host Rho protein signal transduction by symbiont" EXACT [];"modulation of host Rho protein signaling by symbiont" EXACT [];"modulation of host Rho protein signalling by symbiont" EXACT [];"regulation by symbiont of host Rho protein signal transduction" EXACT [] biological_process GO:0044283 small molecule biosynthetic process subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0044409 symbiont entry into host name symbiont entry into host WAS entry into host synonyms "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb];"entry into cell of other organism involved in symbiotic interaction" RELATED [];"entry into host" EXACT [];"entry into host cell via penetration peg" NARROW [];"entry into host through host barriers" RELATED [];"entry into host via a specialized structure during symbiotic interaction" NARROW [];"entry into host via enzymatic degradation of host anatomical structure" NARROW [];"entry into host via enzymatic degradation of host cuticle" NARROW [];"entry into other organism during symbiotic interaction" RELATED [GOC:tb];"entry into other organism involved in symbiotic interaction" RELATED [];"host invasion" EXACT [];"host penetration" EXACT [GOC:vw];"invasion into host" EXACT [];"invasion into other organism" RELATED [];"invasion of host" EXACT [];"invasion of other organism" RELATED [];"invasive growth" RELATED [];"other organism invasion" RELATED [];"penetration into host" EXACT [GOC:vw];"penetration into host via a specialized structure" NARROW [GOC:vw];"penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw] WAS "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb];"entry into cell of other organism involved in symbiotic interaction" RELATED [];"entry into host cell" NARROW [];"entry into host cell via penetration peg" NARROW [];"entry into host through host barriers" RELATED [];"entry into host via a specialized structure during symbiotic interaction" NARROW [];"entry into host via enzymatic degradation of host anatomical structure" NARROW [];"entry into host via enzymatic degradation of host cuticle" NARROW [];"entry into other organism during symbiotic interaction" RELATED [GOC:tb];"entry into other organism involved in symbiotic interaction" RELATED [];"host cell invasion" NARROW [];"host invasion" EXACT [];"host penetration" EXACT [GOC:vw];"invasion into host" EXACT [];"invasion into other organism" RELATED [];"invasion of host" EXACT [];"invasion of other organism" RELATED [];"invasive growth" RELATED [];"other organism cell invasion" NARROW [];"other organism invasion" RELATED [];"penetration into host" EXACT [GOC:vw];"penetration into host via a specialized structure" NARROW [GOC:vw];"penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw] biological_process GO:0044414 symbiont-mediated suppression of host defenses name symbiont-mediated suppression of host defenses WAS suppression of host defenses by symbiont definition "A process in which a symbiont interferes with, inhibits or disrupts the normal execution of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:curators] WAS "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonyms "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"down regulation by symbiont of host defense response" EXACT [];"down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"down-regulation by symbiont of host defense response" EXACT [];"downregulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"downregulation by symbiont of host defense response" EXACT [];"inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [];"inhibition by symbiont of host defense response" NARROW [];"negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph];"negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT [];"negative regulation by symbiont of host defense response" EXACT [];"negative regulation of host defenses" EXACT [];"suppression of defense response of other organism" EXACT [];"suppression of defense response of other organism involved in symbiotic interaction" RELATED [];"suppression of defenses of other organism involved in symbiotic interaction" BROAD [];"suppression of host defense response" EXACT [];"suppression of host defenses by symbiont" EXACT [] WAS "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"down regulation by symbiont of host defense response" EXACT [];"down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"down-regulation by symbiont of host defense response" EXACT [];"downregulation by organism of defense response of other organism during symbiotic interaction" RELATED [];"downregulation by symbiont of host defense response" EXACT [];"inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [];"inhibition by symbiont of host defense response" NARROW [];"negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph];"negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT [];"negative regulation by symbiont of host defense response" EXACT [];"negative regulation of host defenses" EXACT [];"suppression of defense response of other organism" EXACT [];"suppression of defense response of other organism involved in symbiotic interaction" RELATED [];"suppression of defenses of other organism involved in symbiotic interaction" BROAD [];"suppression of host defense response" EXACT [] biological_process GO:0044523 envenomation resulting in damage of muscle extracellular matrix in another organism definition "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:20398688, PMID:21150580, PMID:33460638] WAS "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] biological_process GO:0044539 long-chain fatty acid import into cell definition "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:jl, GOC:pm, PMID:22022213] WAS "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:jl, GOC:pm, PMID:22022213] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0044550 secondary metabolite biosynthetic process subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0044694 symbiont genome entry into host cell via pore formation in plasma membrane name symbiont genome entry into host cell via pore formation in plasma membrane WAS pore-mediated entry of viral genome into host cell definition "Entry of a symbiont's genome into a host cell by a pore formed by the symbiont in the host cell. Examples of this process include injection by a non-enveloped virus of the viral genome into the host cytoplasm, usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, VZ:979] WAS "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, UniProtKB-KW:KW-1172, VZ:979] synonyms "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172];"pore-mediated entry of viral genome into host cell" NARROW [];"pore-mediated penetration of viral genome into host cell" RELATED [];"viral entry via genome injection" RELATED [];"viral genome delivery via icosahedral vertex" NARROW [];"viral genome translocation" EXACT [];"viral pore-forming protein" NARROW [GOC:bf] WAS "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172];"pore-mediated penetration of viral genome into host cell" EXACT [];"viral entry via genome injection" EXACT [];"viral genome delivery via icosahedral vertex" NARROW [];"viral genome translocation" EXACT [];"viral pore-forming protein" RELATED [GOC:bf] biological_process GO:0045022 early endosome to late endosome transport definition "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602] WAS "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194] synonyms "endosome maturation" RELATED [PMID:21878991, PMID:29980602] WAS N/A biological_process GO:0045815 transcription initiation-coupled chromatin remodeling synonyms "chromatin-mediated maintenance of transcription" EXACT [];"DNA replication-independent chromatin organization" RELATED [];"epigenetic maintenance of chromatin in transcription-competent conformation" EXACT [];"euchromatin assembly" RELATED [];"euchromatin organisation" RELATED [];"euchromatin organization" RELATED [];"long-term maintenance of gene activation" RELATED [];"maintenance of chromatin in transcription-competent conformation" EXACT [];"transciptional initiation-coupled chromatin remodeling" EXACT [];"transciptional initiation-coupled chromatin remodelling" EXACT [];"transcription initiation coupled chromatin remodeling" EXACT [];"transcription initiation coupled chromatin remodelling" EXACT [];"transcriptional initiation-coupled chromatin remodeling" EXACT [];"transcriptional initiation-coupled chromatin remodelling" EXACT [] WAS "activation of gene expression, epigenetic" RELATED [];"chromatin-mediated maintenance of transcription" EXACT [];"DNA replication-independent chromatin organization" RELATED [];"epigenetic maintenance of chromatin in transcription-competent conformation" EXACT [];"euchromatin assembly" RELATED [];"euchromatin organisation" RELATED [];"euchromatin organization" RELATED [];"long-term maintenance of gene activation" RELATED [];"maintenance of chromatin in transcription-competent conformation" EXACT [];"positive regulation of gene expression, epigenetic" EXACT [];"stimulation of gene expression, epigenetic" RELATED [];"transciptional initiation-coupled chromatin remodeling" EXACT [];"transciptional initiation-coupled chromatin remodelling" EXACT [];"transcription initiation coupled chromatin remodeling" EXACT [];"transcription initiation coupled chromatin remodelling" EXACT [];"transcriptional initiation-coupled chromatin remodeling" EXACT [];"transcriptional initiation-coupled chromatin remodelling" EXACT [];"up regulation of gene expression, epigenetic" EXACT [];"up-regulation of gene expression, epigenetic" EXACT [];"upregulation of gene expression, epigenetic" EXACT [] biological_process GO:0046459 short-chain fatty acid metabolic process definition "The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism] WAS "The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons." [Wikipedia:Fatty_acid_metabolism] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0046718 symbiont entry into host cell name symbiont entry into host cell WAS viral entry into host cell definition "The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell." [GOC:jl] WAS "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl] synonyms "entry of virus into host cell" NARROW [];"phage translocation" NARROW [];"viral entry into host cell" NARROW [];"viral penetration" NARROW [];"virion penetration" NARROW [];"virion penetration into host cell" NARROW [];"virus entry into host cell" NARROW [] WAS "entry of virus into host cell" EXACT [];"phage translocation" EXACT [];"viral penetration" EXACT [];"virion penetration" EXACT [];"virion penetration into host cell" EXACT [];"virus entry into host cell" EXACT [GOC:bf] biological_process GO:0046925 peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine definition "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, PMID:36302388, RESID:AA0341] WAS "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341] biological_process GO:0046926 peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine definition "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, PMID:36302388, RESID:AA0342] WAS "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342] biological_process GO:0048870 cell motility subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;prokaryote_subset biological_process GO:0050896 response to stimulus subsets gocheck_do_not_manually_annotate;goslim_agr;goslim_flybase_ribbon;goslim_mouse;goslim_pir;goslim_prokaryote WAS gocheck_do_not_manually_annotate;goslim_agr;goslim_flybase_ribbon;goslim_mouse;goslim_pir;prokaryote_subset biological_process GO:0051604 protein maturation subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0051790 short-chain fatty acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [Wikipedia:Fatty_acid_metabolism] WAS "The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of less than 6 carbons." [Wikipedia:Fatty_acid_metabolism] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0051791 medium-chain fatty acid metabolic process definition "The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms] WAS "The chemical reactions and pathways involving a medium-chain fatty acid, a fatty acid with an aliphatic tail of 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0051792 medium-chain fatty acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism] WAS "The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0051793 medium-chain fatty acid catabolic process definition "The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism] WAS "The chemical reactions and pathways resulting in the breakdown of a fatty acid with an aliphatic tail of 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0052026 symbiont-mediated perturbation of host transcription name symbiont-mediated perturbation of host transcription WAS modulation by symbiont of host transcription definition "A process by which a symbiont alters or subverts the normal execution of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] WAS "Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "modulation by symbiont of host transcription" EXACT [] WAS N/A biological_process GO:0052027 symbiont-mediated perturbation of host signal transduction pathway name symbiont-mediated perturbation of host signal transduction pathway WAS perturbation of host signal transduction pathway synonyms "modulation by symbiont of host signal transduction" RELATED [];"modulation by symbiont of host signal transduction pathway" EXACT [];"modulation of host signal transduction by symbiont" EXACT [];"modulation of signal transduction in other organism involved in symbiotic interaction" BROAD [];"perturbation of host signal transduction pathway" EXACT [];"regulation by symbiont of host signal transduction pathway" EXACT [] WAS "modulation by symbiont of host signal transduction" RELATED [];"modulation by symbiont of host signal transduction pathway" EXACT [];"modulation of host signal transduction by symbiont" EXACT [];"modulation of signal transduction in other organism involved in symbiotic interaction" BROAD [];"regulation by symbiont of host signal transduction pathway" EXACT [] biological_process GO:0052064 symbiont-mediated activation of reactive oxygen species production in host cell name symbiont-mediated activation of reactive oxygen species production in host cell WAS induction by symbiont of defense-related host reactive oxygen species production definition "The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30823485] WAS "The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "activation by symbiont of defense-related host metabolic burst" EXACT [];"activation by symbiont of defense-related host oxidative burst" EXACT [];"activation by symbiont of defense-related host reactive oxidative species production" EXACT [];"activation by symbiont of defense-related host reactive oxygen intermediate production" EXACT [];"activation by symbiont of defense-related host reactive oxygen species production" EXACT [];"activation by symbiont of defense-related host respiratory burst" EXACT [];"activation by symbiont of defense-related host ROI production" EXACT [];"activation by symbiont of defense-related host ROS production" EXACT [];"induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"induction by symbiont of defense-related host active oxygen species production" EXACT [];"induction by symbiont of defense-related host AOS production" EXACT [];"induction by symbiont of defense-related host metabolic burst" EXACT [];"induction by symbiont of defense-related host oxidative burst" EXACT [];"induction by symbiont of defense-related host reactive oxidative species production" EXACT [];"induction by symbiont of defense-related host reactive oxygen species production" RELATED [];"induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"positive regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"stimulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"up regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"up-regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"upregulation by symbiont of defense-related host reactive oxygen species production" RELATED [] WAS "activation by symbiont of defense-related host metabolic burst" EXACT [];"activation by symbiont of defense-related host oxidative burst" EXACT [];"activation by symbiont of defense-related host reactive oxidative species production" EXACT [];"activation by symbiont of defense-related host reactive oxygen intermediate production" EXACT [];"activation by symbiont of defense-related host reactive oxygen species production" EXACT [];"activation by symbiont of defense-related host respiratory burst" EXACT [];"activation by symbiont of defense-related host ROI production" EXACT [];"activation by symbiont of defense-related host ROS production" EXACT [];"induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"induction by symbiont of defense-related host active oxygen species production" EXACT [];"induction by symbiont of defense-related host AOS production" EXACT [];"induction by symbiont of defense-related host metabolic burst" EXACT [];"induction by symbiont of defense-related host oxidative burst" EXACT [];"induction by symbiont of defense-related host reactive oxidative species production" EXACT [];"induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [];"positive regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"stimulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"up regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"up-regulation by symbiont of defense-related host reactive oxygen species production" RELATED [];"upregulation by symbiont of defense-related host reactive oxygen species production" RELATED [] biological_process GO:0052078 symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18005697] WAS "A process in which a virus interferes with, inhibits or disrupts a PAMP signaling pathway in its host organism, initiated by a ligand binding of a pattern recognition receptor (PRR) to activate a plant innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18005697] synonyms "disruption of host PAMP receptor signaling pathway" EXACT [];"disruption of host pathogen-associated molecular pattern receptor signaling pathway" EXACT [];"suppression of host pathogen-associated molecular pattern receptor signaling pathway" NARROW [] WAS "disruption of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [];"disruption of host PAMP receptor signaling pathway" EXACT [];"disruption of host pathogen-associated molecular pattern receptor signaling pathway" EXACT [];"inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [];"suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [];"suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [];"suppression of host pathogen-associated molecular pattern receptor signaling pathway" NARROW [] biological_process GO:0052080 symbiont-mediated perturbation of host MAPK cascade name symbiont-mediated perturbation of host MAPK cascade WAS perturbation of host MAPK signal transduction pathway synonyms "modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" RELATED [];"modulation by symbiont of host innate immune response MAPK kinase signaling" NARROW [];"modulation of defense-related host MAPK-mediated signal transduction pathway by organism" NARROW [];"modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" NARROW [];"pertubation of host innate immune response MAPK kinase signaling" NARROW [];"perturbation by symbiont of host MAP kinase signal transduction pathway" EXACT [];"perturbation of host MAP signal transduction pathway" EXACT [];"perturbation of host MAPK kinase signaling pathway" EXACT [];"perturbation of host MAPK signal transduction pathway" EXACT [] WAS "modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" RELATED [];"modulation by symbiont of host innate immune response MAPK kinase signaling" NARROW [];"modulation of defense-related host MAPK-mediated signal transduction pathway by organism" NARROW [];"modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" NARROW [];"pertubation of host innate immune response MAPK kinase signaling" NARROW [];"perturbation by symbiont of host MAP kinase signal transduction pathway" EXACT [];"perturbation of host MAP signal transduction pathway" EXACT [];"perturbation of host MAPK kinase signaling pathway" EXACT [] biological_process GO:0052081 symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway name symbiont-mediated perturbation of host salicylic acid-mediated signal transduction pathway WAS perturbation of defense-related host salicylic acid-mediated signal transduction pathway synonyms "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [];"modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [];"modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [];"perturbation of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] WAS "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [];"modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [];"modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [] biological_process GO:0052103 induction of host induced systemic resistance definition "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:31516360] WAS "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] biological_process GO:0052170 symbiont-mediated suppression of host innate immune response name symbiont-mediated suppression of host innate immune response WAS suppression of host innate immune response definition "A process in which a symbiont interferes with, inhibits or disrupts the normal execution of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] WAS "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "down regulation by symbiont of host innate immunity" EXACT [];"down-regulation by symbiont of host innate immunity" EXACT [];"downregulation by symbiont of host innate immunity" EXACT [];"inhibition by symbiont of host innate immunity" NARROW [];"negative regulation by symbiont of host innate immune response" EXACT [];"negative regulation by symbiont of host innate immunity" EXACT [GOC:pg];"negative regulation of host innate immune response" EXACT [];"negative regulation of innate immune response in other organism" BROAD [];"suppression by symbiont of host innate immune response" EXACT [];"suppression of host innate immune response" EXACT [] WAS "down regulation by symbiont of host innate immunity" EXACT [];"down-regulation by symbiont of host innate immunity" EXACT [];"downregulation by symbiont of host innate immunity" EXACT [];"inhibition by symbiont of host innate immunity" NARROW [];"negative regulation by symbiont of host innate immune response" EXACT [];"negative regulation by symbiont of host innate immunity" EXACT [GOC:pg];"negative regulation of host innate immune response" EXACT [];"negative regulation of innate immune response in other organism" BROAD [];"suppression by symbiont of host innate immune response" EXACT [] biological_process GO:0052562 symbiont-mediated suppression of host immune response name symbiont-mediated suppression of host immune response WAS suppression by symbiont of host immune response definition "Any process in which a symbiont interferes with, inhibits or disrupts the normal execution of an immune response of the host organism. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] WAS "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonyms "down regulation by symbiont of host immune response" EXACT [];"down-regulation by symbiont of host immune response" EXACT [];"downregulation by symbiont of host immune response" EXACT [];"inhibition by symbiont of host immune response" NARROW [];"negative regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [];"negative regulation by symbiont of host immune response" EXACT [];"suppression by symbiont of host immune response" EXACT [] WAS "down regulation by symbiont of host immune response" EXACT [];"down-regulation by symbiont of host immune response" EXACT [];"downregulation by symbiont of host immune response" EXACT [];"inhibition by symbiont of host immune response" NARROW [];"negative regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [];"negative regulation by symbiont of host immune response" EXACT [] biological_process GO:0055062 phosphate ion homeostasis synonyms "phosphate homeostasis" BROAD [];"Pi homeostasis" EXACT [] WAS N/A biological_process GO:0055086 nucleobase-containing small molecule metabolic process subsets goslim_drosophila;goslim_generic;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_drosophila;goslim_generic;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0060395 SMAD protein signal transduction definition "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF] WAS "An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes." [GOC:BHF] biological_process GO:0061024 membrane organization subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0062200 RAM/MOR signaling name RAM/MOR signaling WAS RAM/MOR signaling pathway definition "An intracellular signaling cascade that starts with the activation of S. cerevisiae Kic1p, which activate Mob2p and Cbk1p. Cbk1p phosphorylates Ace2p, which results in its nuclear translocation, where it regulates transcription of genes involved in polarity and morphogenesis." [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372, PMID:23212898] WAS "An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase." [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372] synonyms "MOR signaling pathway" NARROW [];"morphogenesis Orb6 network" EXACT [];"RAM signaling pathway" NARROW [];"RAM/MOR signaling pathway" EXACT [] WAS "MOR signaling pathway" NARROW [];"morphogenesis Orb6 network" EXACT [];"RAM signaling pathway" NARROW [] biological_process GO:0065003 protein-containing complex assembly subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_pombe;prokaryote_subset biological_process GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway name regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway WAS regulation of nucleotide-binding oligomerization domain containing signaling pathway definition "Any process that modulates the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add] WAS "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonyms "regulation of NOD signaling pathway" NARROW [GOC:add];"regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW [];"regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah] WAS "regulation of NOD signaling pathway" EXACT [GOC:add];"regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] biological_process GO:0070425 negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway name negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway WAS negative regulation of nucleotide-binding oligomerization domain containing signaling pathway definition "Any process that stops, prevents, or reduces the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add] WAS "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonyms "negative regulation of NOD signaling pathway" NARROW [GOC:add];"negative regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW [];"negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah] WAS "negative regulation of NOD signaling pathway" EXACT [GOC:add];"negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] biological_process GO:0070426 positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway name positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway WAS positive regulation of nucleotide-binding oligomerization domain containing signaling pathway definition "Any process that activates or increases the frequency, rate, or extent of a nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (NLR) pathway." [GOC:add] WAS "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonyms "positive regulation of NOD signaling pathway" NARROW [GOC:add];"positive regulation of nucleotide-binding oligomerization domain containing signaling pathway" NARROW [];"positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" NARROW [GOC:mah] WAS "positive regulation of NOD signaling pathway" EXACT [GOC:add];"positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] biological_process GO:0071554 cell wall organization or biogenesis subsets goslim_chembl;goslim_generic;goslim_pombe;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_generic;goslim_pombe;goslim_yeast;prokaryote_subset biological_process GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system definition "A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726] WAS "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635, PMID:21211726, PMID:21324894] comment N/A WAS See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. biological_process GO:0071941 nitrogen cycle metabolic process subsets goslim_chembl;goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_chembl;goslim_generic;goslim_pombe;prokaryote_subset biological_process GO:0072657 protein localization to membrane subsets goslim_prokaryote WAS prokaryote_subset biological_process GO:0075109 symbiont-mediated perturbation of host receptor-mediated signal transduction name symbiont-mediated perturbation of host receptor-mediated signal transduction WAS perturbation of host receptor-mediated signal transduction definition "A process by which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] WAS "A process in which a symbiont alters or subverts a receptor-mediated signal transduction pathway in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment N/A WAS Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". synonyms "perturbation of host receptor-mediated signal transduction" EXACT [] WAS N/A biological_process GO:0075118 symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway name symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway WAS perturbation of host G protein-coupled receptor signal transduction pathway definition "A process by which a symbiont alters or subverts the normal execution of a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] WAS "Any process in which the symbiont alters a host G protein-coupled receptor signal transduction pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment N/A WAS Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075087". synonyms "modulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [];"modulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [];"modulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [];"modulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [];"modulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [];"perturbation of host G protein-coupled receptor signal transduction pathway" EXACT [] WAS "modulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [];"modulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [];"modulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [];"modulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [];"modulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] biological_process GO:0075120 symbiont-mediated suppression of host G protein-coupled receptor signal transduction comment N/A WAS Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075089". biological_process GO:0075133 symbiont-mediated perturbation of host calcium or calmodulin-mediated signal transduction name symbiont-mediated perturbation of host calcium or calmodulin-mediated signal transduction WAS perturbation of host calcium or calmodulin-mediated signal transduction comment N/A WAS Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". synonyms "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [];"perturbation of host calcium or calmodulin-mediated signal transduction" EXACT [] WAS "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] biological_process GO:0075135 symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction comment N/A WAS Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". biological_process GO:0085032 symbiont-mediated perturbation of host NF-kappaB cascade name symbiont-mediated perturbation of host NF-kappaB cascade WAS pertubation of host canonical NF-kappaB cascade definition "A process in which a symbiont alters or subverts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] WAS "A process in which a symbiont alters or subverts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonyms "modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" RELATED [];"pertubation of host canonical NF-kappaB cascade" RELATED [];"pertubation of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"symbiont-mediated pertubation of host canonical NF-kappaB cascade" RELATED [];"symbiont-mediated perturbation of host canonical NF-kappaB cascade" RELATED [] WAS "modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [];"pertubation of host I-kappaB kinase/NF-kappaB cascade" EXACT [] biological_process GO:0085033 symbiont-mediated activation of host NF-kappaB signal transduction name symbiont-mediated activation of host NF-kappaB signal transduction WAS induction of host canonical NF-kappaB signal transduction definition "A process that initiates, promotes, or enhances a host NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:11907233, PMID:17490702, PMID:21098302, PMID:21199955, PMID:31311877, PMID:7845680] WAS "A process that initiates, promotes, or enhances a canonical NF-kappaB-mediated signaling cascade. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17490702, PMID:21098302, PMID:21199955, PMID:31311877] synonyms "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"induction of host canonical NF-kappaB signal transduction" RELATED [];"induction of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" RELATED [];"stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"symbiont-mediated activation of host canonical NF-kappaB signal transduction" RELATED [];"up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [] WAS "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"induction of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [];"positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway" EXACT [];"stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] biological_process GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade name symbiont-mediated suppression of host NF-kappaB cascade WAS symbiont-mediated suppression of host canonical NF-kappaB cascade definition "A process in which a symbiont interferes with, inhibits or disrupts an NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18250452, PMID:22442494, PMID:24648522, PMID:33567255] WAS "A process in which a symbiont interferes with, inhibits or disrupts a canonical NF-kappaB-mediated signaling cascade in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18250452, PMID:22442494, PMID:24648522, PMID:33567255] synonyms "disruption of host canonical NF-kappaB cascade" RELATED [];"disruption of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade" RELATED [];"symbiont-mediated suppression of host canonical NF-kappaB cascade" RELATED [] WAS "disruption of host canonical NF-kappaB cascade" EXACT [];"disruption of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [];"suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] biological_process GO:0098003 viral tail assembly definition "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm, VZ:3955] WAS "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm] biological_process GO:0098004 virus tail fiber assembly definition "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm, VZ:3956] WAS "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm] biological_process GO:0098542 defense response to other organism subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset biological_process GO:0098672 suppression of host CRISPR-cas system name suppression of host CRISPR-cas system WAS inhibition of host CRISPR-cas system by virus definition "A process by which a symbiont interferes with, inhibits or disrupts the CRISPR-cas system of its host. Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves from infection by bacteriophages (phages), and phages have various mechanisms to counter the CRISPR-cas system." [PMID:23242138, PMID:23446421, PMID:26416740, PMID:28749735] WAS "A process by which a virus inhibits the CRISPR-cas system of its host." [PMID:23242138, PMID:23446421, PMID:26416740, PMID:28749735] synonyms "anti-CRISPR" BROAD [];"CRISPR-cas system evasion by virus" EXACT [VZ:3962];"evasion by virus of CRISPR-cas system" RELATED [];"inhibition of host CRISPR-cas system by virus" RELATED [] WAS "anti-CRISPR" BROAD [];"CRISPR-cas system evasion by virus" EXACT [VZ:3962];"evasion by virus of CRISPR-cas system" RELATED [] biological_process GO:0098677 virion maturation definition "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection." [ISBN:0781718325, VZ:1946] WAS "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection." [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946] biological_process GO:0098754 detoxification subsets goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_generic;goslim_pombe;prokaryote_subset biological_process GO:0098932 symbiont entry into host cell via disruption of host cell wall peptidoglycan name symbiont entry into host cell via disruption of host cell wall peptidoglycan WAS disruption by virus of host cell wall peptidoglycan during virus entry definition "The disruption by a symbiont of host cell wall peptidoglycans to allow entry into the host cell." [GOC:dos, VZ:3940] WAS "A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry." [GOC:dos, VZ:3940] synonyms "catabolism of host cell wall peptidoglycan by virus" EXACT [];"degradation of host cell wall peptidoglycan by virus" EXACT [];"degradation of host peptidoglycans during virus entry" EXACT [VZ:3940];"disassembly by virus of host cell wall peptidoglycan" EXACT [];"disruption by virus of host cell wall peptidoglycan during virus entry" EXACT [] WAS "catabolism of host cell wall peptidoglycan by virus" EXACT [];"degradation of host cell wall peptidoglycan by virus" EXACT [];"degradation of host peptidoglycans during virus entry" EXACT [VZ:3940];"disassembly by virus of host cell wall peptidoglycan" EXACT [] biological_process GO:0098994 symbiont entry into host cell via disruption of host cell envelope name symbiont entry into host cell via disruption of host cell envelope WAS disruption of host cell envelope during viral entry definition "The disruption by a symbiont of host cell envelope components to allow entry into the host cell." [GOC:dos] WAS "The disruption of host cell envelope by viral proteins during virus entry." [GOC:dos] synonyms "disruption of host cell envelope during viral entry" EXACT [] WAS N/A biological_process GO:0098995 symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide name symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide WAS disruption by virus of host envelope lipopolysaccharide during virus entry definition "The disruption by a symbiont of host cell wall lipopolysaccharides to allow entry into the host cell. For example a phage entering a Gram-negative bacterium may actively break down outer membrane lipopolysaccharides." [GOC:dos, VZ:3940] WAS "The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides." [GOC:dos, VZ:3940] synonyms "degradation of host cell envelope lipopolysaccharide during viral entry" EXACT [];"degradation of host lipopolysaccharide during virus entry" EXACT [VZ:3940];"disassembly by virus of outer membrane lipopolysaccharide during viral entry" NARROW [];"disruption by virus of host envelope lipopolysaccharide during virus entry" EXACT [] WAS "degradation of host cell envelope lipopolysaccharide during viral entry" EXACT [];"degradation of host lipopolysaccharide during virus entry" EXACT [VZ:3940];"disassembly by virus of outer membrane lipopolysaccharide during viral entry" NARROW [] biological_process GO:0098996 symbiont entry into host cell via disruption of host cell glycocalyx name symbiont entry into host cell via disruption of host cell glycocalyx WAS disruption of host cell glycocalyx during viral entry definition "The disruption by a symbiont of host cell capsule to allow entry into the host cell." [GOC:dos] WAS "The disruption of host cell glycocalyx by viral proteins during virus entry." [GOC:dos] synonyms "catabolism of host glycocalyx during viral entry" EXACT [];"degradation of host capsule during virus entry" EXACT [VZ:3896];"degradation of host glycocalyx during viral entry" EXACT [];"disassembly of glycocalyx during viral entry" EXACT [];"disruption of host cell glycocalyx during viral entry" EXACT [];"symbiont entry into host cell by disruption of host cell capsule" EXACT [] WAS "catabolism of host glycocalyx during viral entry" EXACT [];"degradation of host capsule during virus entry" EXACT [VZ:3896];"degradation of host glycocalyx during viral entry" EXACT [];"disassembly of glycocalyx during viral entry" EXACT [] biological_process GO:0099000 symbiont genome ejection through host cell envelope, contractile tail mechanism name symbiont genome ejection through host cell envelope, contractile tail mechanism WAS viral genome ejection through host cell envelope, contractile tail mechanism definition "Entry of a symbiont's genome into the host cell through the host cell envelope via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:26283379, VZ:3950] WAS "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope." [GOC:dos, PMID:26283379, VZ:3950] synonyms "viral contractile tail ejection system" EXACT [VZ:3950];"viral genome ejection through host cell envelope, contractile tail mechanism" RELATED [] WAS "viral contractile tail ejection system" EXACT [VZ:3950] biological_process GO:0099001 symbiont genome ejection through host cell envelope, long flexible tail mechanism name symbiont genome ejection through host cell envelope, long flexible tail mechanism WAS viral genome ejection through host cell envelope, long flexible tail mechanism definition "Entry of a symbiont's genome into the host cell through the host cell envelope via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:22297512, VZ:3952] WAS "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm." [GOC:dos, PMID:22297512, VZ:3952] synonyms "viral genome ejection through host cell envelope, long flexible tail mechanism" RELATED [];"viral long flexible tail ejection system" EXACT [VZ:3952] WAS "viral long flexible tail ejection system" EXACT [VZ:3952] biological_process GO:0099002 symbiont genome ejection through host cell envelope, short tail mechanism name symbiont genome ejection through host cell envelope, short tail mechanism WAS viral genome ejection through host cell envelope, short tail mechanism definition "Entry of a symbiont's genome into the host cell through the host cell envelope via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. Occurs in non-enveloped prokaryotic viruses." [GOC:dos, PMID:22297513, VZ:3954] WAS "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties." [GOC:dos, PMID:22297513, VZ:3954] synonyms "viral genome ejection through host cell envelope, short tail mechanism" RELATED [];"viral short tail ejection system" EXACT [VZ:3954] WAS "viral short tail ejection system" EXACT [VZ:3954] biological_process GO:0099006 symbiont entry into host cell via permeabilization of endosomal membrane name symbiont entry into host cell via permeabilization of endosomal membrane WAS viral entry via permeabilization of endosomal membrane definition "The entry of a symbiont into a host cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) of the symbiont. This process mediates the entry of some non-enveloped virus into eukaryotic cells. In some cases, viral membrane-penetration protein requires to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen." [PMID:15329727, PMID:25055856] WAS "The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen." [PMID:15329727, PMID:25055856, VZ:985] synonyms "viral entry via permeabilization of endosomal membrane" NARROW [] WAS "viral penetration via permeabilization of host membrane" BROAD [vz:985] biological_process GO:0099008 symbiont entry into host cell via permeabilization of inner membrane name symbiont entry into host cell via permeabilization of inner membrane WAS viral entry via permeabilization of inner membrane definition "The entry of a symbiont into the cytoplasm of a host cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. This process mediates the entry of some non-enveloped viruses into prokaryotic cells. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization and permeabilization of the plasma membrane." [PMID:15795287, PMID:20427561] WAS "The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane." [PMID:15795287, PMID:20427561, VZ:985] synonyms "viral entry via permeabilization of inner membrane" NARROW [] WAS "viral penetration via permeabilization of host membrane" BROAD [vz:985] biological_process GO:0099016 evasion of DNA end degradation by host name evasion of DNA end degradation by host WAS evasion by virus of DNA end degradation definition "A process by which a symbiont evades and ends degradation of its DNA when free DNA ends are exposed. DNA ends are exposed during the life cycle of some viruses and these are targeted by host cells to destroy the virus. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases." [GOC:dos, PMID:11894948, PMID:16949369, VZ:3963] WAS "A process by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases." [GOC:dos] synonyms "DNA end degradation evasion by virus" EXACT [];"evasion by virus of DNA end degradation" RELATED [] WAS "DNA end degradation evasion by virus" EXACT [] biological_process GO:0099018 evasion of host restriction-modification system name evasion of host restriction-modification system WAS evasion by virus of host restriction-modification system definition "A process by which a symbiont evades the DNA restriction modification system of its host. This process occurs in phages to protein themselves from bacterial restriction enzyme systems. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction." [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966] WAS "Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction." [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966] synonyms "evasion by virus of host restriction-modification system" RELATED [];"restriction-modification system evasion by virus" EXACT [] WAS "restriction-modification system evasion by virus" EXACT [] biological_process GO:0140133 symbiont-mediated suppression of host cytokine production name symbiont-mediated suppression of host cytokine production WAS suppression by symbiont of host cytokine production definition "A process by which a symbiont inhibits or disrupts the normal rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23083102] WAS "Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23083102] synonyms "negative regulation by symbiont of host cytokine production" EXACT [];"suppression by symbiont of host cytokine production" EXACT [];"suppression by symbiont of host cytokine secretion" RELATED [] WAS "negative regulation by symbiont of host cytokine production" EXACT [];"suppression by symbiont of host cytokine secretion" RELATED [] biological_process GO:0140267 symbiont entry into host cell via permeabilization of host membrane name symbiont entry into host cell via permeabilization of host membrane WAS viral entry via permeabilization of host membrane definition "The entry of a symbiont into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration symbiont protein. This process mediates the entry of some non-enveloped virus into host cells, and results in the release of the virus contents into the host cell cytoplasm." [PMID:20427561, PMID:25055856, VZ:985] WAS "The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm." [PMID:20427561, PMID:25055856] synonyms "viral entry via permeabilization of host membrane" NARROW [] WAS N/A subsets N/A WAS gocheck_do_not_annotate biological_process GO:0140493 very long-chain fatty acid beta-oxidation definition "A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171] WAS "A fatty acid beta-oxidation pathway acting on a very long chain fatty acid, a fatty acid with an aliphatic tail of 22 or more carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A biological_process GO:0140546 defense response to symbiont definition "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] WAS "Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont." [GOC:pg] biological_process GO:0140884 symbiont-mediated suppression of host type II interferon-mediated signaling pathway name symbiont-mediated suppression of host type II interferon-mediated signaling pathway WAS suppression by virus of host type II interferon-mediated signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma." [PMID:28901902] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type II interferon-mediated signaling in the host organism. Type II interferon is also known as interferon-gamma." [PMID:28901902] synonyms "negative regulation by virus of host type II interferon-mediated signaling pathway" EXACT [];"suppression by virus of host type II IFN-mediated signaling pathway" EXACT [];"suppression by virus of host type II interferon-mediated signaling pathway" NARROW [];"suppression by virus of host type II interferon-mediated signalling pathway" EXACT [] WAS "negative regulation by virus of host type II interferon-mediated signaling pathway" EXACT [];"suppression by virus of host type II IFN-mediated signaling pathway" EXACT [];"suppression by virus of host type II interferon-mediated signalling pathway" EXACT [] biological_process GO:0140885 symbiont-mediated suppression of host type III interferon-mediated signaling pathway name symbiont-mediated suppression of host type III interferon-mediated signaling pathway WAS suppression by virus of host type III interferon-mediated signaling pathway definition "A process in which a symbiont interferes with, inhibits or disrupts a type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda." [PMID:32464097] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type III interferon-mediated signaling in the host organism. Type III interferon is also known as interferon-lambda." [PMID:32464097] synonyms "negative regulation by virus of host type III interferon-mediated signaling pathway" EXACT [];"suppression by virus of host type III IFN-mediated signaling pathway" EXACT [];"suppression by virus of host type III interferon-mediated signaling pathway" NARROW [];"suppression by virus of host type III interferon-mediated signalling pathway" EXACT [] WAS "negative regulation by virus of host type III interferon-mediated signaling pathway" EXACT [];"suppression by virus of host type III IFN-mediated signaling pathway" EXACT [];"suppression by virus of host type III interferon-mediated signalling pathway" EXACT [] biological_process GO:0140886 symbiont-mediated suppression of host interferon-mediated signaling pathway name symbiont-mediated suppression of host interferon-mediated signaling pathway WAS suppression by virus of host interferon-mediated signaling pathway definition "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism." [PMID:31266861, PMID:33097660, PMID:34305858] WAS "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interferon-mediated signaling in the host organism." [PMID:33097660] synonyms "inhibition of host interferon signaling pathway by symbiont" RELATED [];"negative regulation by virus of host interferon-mediated signaling pathway" NARROW [];"suppression by symbiont of host IFN-mediated signaling pathway" EXACT [];"suppression by symbiont of host interferon-mediated signalling pathway" EXACT [];"suppression by virus of host interferon-mediated signaling pathway" NARROW [] WAS "inhibition of host interferon signaling pathway by virus" RELATED [];"negative regulation by virus of host interferon-mediated signaling pathway" EXACT [];"suppression by virus of host IFN-mediated signaling pathway" EXACT [];"suppression by virus of host interferon-mediated signalling pathway" EXACT [] biological_process GO:0140986 G protein-coupled chemorepellent receptor signaling pathway definition "A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization." [PMID:30462573] WAS "A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization." [PMID:30462573] biological_process GO:0141062 disruption of tissue in another organism definition "The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue." [PMID:11895956, PMID:26355030, PMID:27416066, PMID:28194160, PMID:34346770] WAS "The disruption of a tissue of another organism, leading to damage or temporary subversion of that tissue." [PMID:11895956, PMID:26355030, PMID:27416066, PMID:34346770] synonyms "tissue necrosis in another organism" EXACT [] WAS N/A biological_process GO:0141070 symbiont-mediated suppression of host MAPK cascade name symbiont-mediated suppression of host MAPK cascade WAS symbiont-mediated suppression of host MAPK signal transduction pathway synonyms "disruption of host MAP kinase signaling pathway" EXACT [];"disruption of host MAPK signal transduction pathway" EXACT [];"disruption of host MAPK signaling pathway" EXACT [];"symbiont-mediated suppression of host MAPK signal transduction pathway" EXACT [] WAS "disruption of host MAP kinase signaling pathway" EXACT [];"disruption of host MAPK signal transduction pathway" EXACT [];"disruption of host MAPK signaling pathway" EXACT [] biological_process GO:0141071 symbiont-mediated activation of host MAPK cascade name symbiont-mediated activation of host MAPK cascade WAS symbiont-mediated activation of host MAPK signal transduction pathway synonyms "activation by symbiont of host MAPK signal transduction pathway" NARROW [];"induction by symbiont of host MAP kinase signal transduction pathway" EXACT [];"induction of host MAPK kinase signaling pathway" EXACT [];"stimulation by symbiont of host MAPK signal transduction pathway" NARROW [];"symbiont-mediated activation of host MAPK signal transduction pathway" EXACT [] WAS "activation by symbiont of host MAPK signal transduction pathway" NARROW [];"induction by symbiont of host MAP kinase signal transduction pathway" EXACT [];"induction of host MAPK kinase signaling pathway" EXACT [];"stimulation by symbiont of host MAPK signal transduction pathway" NARROW [] biological_process GO:0141104 symbiont-mediated activation of host G protein-coupled receptor signal transduction definition "A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15963708, PMID:18978047, PMID:25332123] WAS "A process in which a symbiont G protein-coupled receptor signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:15963708, PMID:18978047, PMID:25332123] biological_process GO:1901135 carbohydrate derivative metabolic process subsets goslim_agr;goslim_generic;goslim_mouse;goslim_prokaryote WAS goslim_agr;goslim_generic;goslim_mouse;prokaryote_subset biological_process GO:1990983 regulation of translational initiation by tRNA modification name regulation of translational initiation by tRNA modification WAS tRNA demethylation definition "A process in which translation initiation is regulated by post-translation modifications of a tRNA molecule." [PMID:27745969] WAS "The removal of a methyl group from one or more residues within a tRNA molecule." [PMID:27745969] synonyms "tRNA demethylation" BROAD [] WAS N/A molecular_function GO:0003677 DNA binding subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0003723 RNA binding subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0003774 cytoskeletal motor activity subsets goslim_candida;goslim_generic;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_candida;goslim_generic;goslim_pir;goslim_plant;prokaryote_subset molecular_function GO:0003924 GTPase activity subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_yeast;prokaryote_subset molecular_function GO:0003953 NAD+ nucleosidase activity synonyms "beta-NAD(+) glycohydrolase activity" EXACT [];"diphosphopyridine nucleosidase activity" EXACT [];"DPNase activity" EXACT [];"NAD glycohydrolase activity" EXACT [];"NAD nucleosidase activity" EXACT [];"NAD(+) glycohydrolase activity" EXACT [];"NADase activity" EXACT [];"nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [];"nicotinamide adenine dinucleotide nucleosidase activity" EXACT [] WAS "NAD nucleosidase activity" EXACT [] molecular_function GO:0004085 butyryl-CoA dehydrogenase activity synonyms N/A WAS "3-hydroxyacyl CoA reductase activity" RELATED [EC:1.3.8.1];"butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" RELATED [EC:1.3.8.1];"butanoyl-CoA:acceptor 2,3-oxidoreductase activity" RELATED [EC:1.3.8.1];"butyryl coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.1];"butyryl dehydrogenase activity" RELATED [EC:1.3.8.1];"enoyl-coenzyme A reductase activity" RELATED [EC:1.3.8.1];"ethylene reductase activity" RELATED [EC:1.3.8.1];"short-chain acyl CoA dehydrogenase activity" RELATED [EC:1.3.8.1];"short-chain acyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.1];"short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1];"unsaturated acyl coenzyme A reductase activity" RELATED [EC:1.3.8.1];"unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1] molecular_function GO:0004164 diphthine synthase activity comment This activity is present in archae and produces the trimethylated product diphthine, which is converted into diphthamide by diphthine-ammonia ligase activity ; GO:0017178 (EC:6.3.1.14). Note tha this is different from the eukaryotic enzyme diphthine methyl ester synthase activity ; GO:0141133 (EC:2.1.1.314), which produces diphthine methyl ester. WAS N/A molecular_function GO:0004317 (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity name (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity WAS (3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity synonyms "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [];"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [];"(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [];"3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [];"3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [];"3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [] WAS "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" RELATED [];"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [];"(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [];"3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" RELATED [];"3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [];"3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [] molecular_function GO:0004361 glutaryl-CoA dehydrogenase activity definition "Catalysis of the reaction WAS "3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:13389] molecular_function GO:0004467 long-chain fatty acid-CoA ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). Note that this term has a MetaCyc pathway reference as the pathway only has a single step. WAS Note that this term has a MetaCyc pathway reference as the pathway only has a single step. molecular_function GO:0004794 threonine deaminase activity name threonine deaminase activity WAS L-threonine ammonia-lyase activity comment N/A WAS Note that this function was formerly EC:4.2.1.16. synonyms "L-serine dehydratase activity" RELATED [EC:4.3.1.19];"L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19];"L-threonine ammonia-lyase activity" EXACT [];"L-threonine deaminase activity" EXACT [EC:4.3.1.19];"L-threonine dehydratase activity" EXACT [EC:4.3.1.19];"L-threonine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.19];"serine deaminase activity" RELATED [EC:4.3.1.19];"threonine ammonia-lyase activity" BROAD [];"threonine dehydrase activity" EXACT [EC:4.3.1.19];"threonine dehydratase activity" BROAD [] WAS "L-serine dehydratase activity" RELATED [EC:4.3.1.19];"L-threonine ammonia-lyase (2-oxobutanoate-forming)" RELATED [EC:4.3.1.19];"L-threonine deaminase activity" RELATED [EC:4.3.1.19];"L-threonine dehydratase activity" RELATED [EC:4.3.1.19];"L-threonine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.19];"serine deaminase activity" RELATED [EC:4.3.1.19];"threonine ammonia-lyase activity" EXACT [];"threonine deaminase activity" RELATED [EC:4.3.1.19];"threonine dehydrase activity" RELATED [EC:4.3.1.19];"threonine dehydratase activity" EXACT [] molecular_function GO:0004848 ureidoglycolate hydrolase activity comment Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.1.116, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.1.116) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.1.116 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. WAS Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. synonyms "ureidoglycolate amidohydrolase activity" EXACT [] WAS "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [] molecular_function GO:0005198 structural molecule activity subsets goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0005215 transporter activity subsets gocheck_do_not_annotate;goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote WAS gocheck_do_not_annotate;goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;prokaryote_subset molecular_function GO:0005324 long-chain fatty acid transporter activity definition "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732] WAS "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [ISBN:0198506732] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0008092 cytoskeletal protein binding subsets goslim_agr;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_yeast;prokaryote_subset molecular_function GO:0008177 succinate dehydrogenase (quinone) activity name succinate dehydrogenase (quinone) activity WAS succinate dehydrogenase (ubiquinone) activity synonyms "fumarate reductase (menaquinone)" NARROW [];"succinate dehydrogenase (menaquinone)" NARROW [];"succinate dehydrogenase (ubiquinone) activity" NARROW [];"succinic dehydrogenase activity" BROAD [EC:1.3.5.1] WAS "succinate:ubiquinone oxidoreductase activity" RELATED [EC:1.3.5.1];"succinic dehydrogenase activity" BROAD [EC:1.3.5.1] molecular_function GO:0008289 lipid binding subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity comment Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. WAS N/A molecular_function GO:0008659 (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity name (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity WAS (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity synonyms "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity" EXACT [];"(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] WAS "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] molecular_function GO:0008693 (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity synonyms "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [];"3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [];"3-hydroxydecanoyl-ACP dehydratase activity" EXACT [];"3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [];"3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [];"3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [];"beta-hydroxyacyl-ACP dehydrase activity" EXACT [];"beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [];"beta-hydroxydecanoate dehydrase activity" EXACT [];"beta-hydroxydecanoyl thioester dehydrase activity" EXACT [] WAS "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" RELATED [];"3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [];"3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" BROAD [];"3-hydroxydecanoyl-ACP dehydratase activity" EXACT [];"3-hydroxydecanoyl-acyl carrier protein dehydrase activity" RELATED [];"3-hydroxydecanoyl-acyl carrier protein dehydratase activity" RELATED [];"3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" RELATED [];"beta-hydroxyacyl-ACP dehydrase activity" RELATED [];"beta-hydroxyacyl-acyl carrier protein dehydratase activity" RELATED [];"beta-hydroxydecanoate dehydrase activity" RELATED [];"beta-hydroxydecanoyl thioester dehydrase activity" RELATED [] molecular_function GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0008941 nitric oxide dioxygenase NAD(P)H activity name nitric oxide dioxygenase NAD(P)H activity WAS nitric oxide dioxygenase activity comment Note that this activity is similar to nitric oxide dioxygenase activity, heme protein ; GO:0141118, but GO:0141118 uses a heme protein as the electron donor. WAS N/A synonyms "nitric oxide dioxygenase activity" BROAD [];"NOD activity" RELATED [EC:1.14.12.17] WAS "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.12.17];"NOD activity" RELATED [EC:1.14.12.17] molecular_function GO:0008942 nitrite reductase [NAD(P)H] activity comment N/A WAS Note that this function was formerly EC:1.6.6.4. molecular_function GO:0009055 electron transfer activity definition "A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer] WAS "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] comment N/A WAS Note that this term should only be be used for electron transfer that generates a transmembrane electrochemical gradient, e.g. components of the respiratory or photosynthetic electron transport chain. molecular_function GO:0009975 cyclase activity subsets goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_generic;goslim_pir;prokaryote_subset molecular_function GO:0010420 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity comment Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. WAS N/A molecular_function GO:0015483 long-chain fatty acid transporting porin activity definition "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, TC:1.B.9.1.1] WAS "Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, TC:1.B.9.1.1] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0015636 short-chain fatty acid transmembrane transporter activity definition "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons." [GOC:mah] WAS "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid is a fatty acid with an aliphatic tail of less than 6 carbons." [GOC:mah] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0016209 antioxidant activity subsets goslim_generic;goslim_metagenomics;goslim_pir;goslim_prokaryote WAS goslim_generic;goslim_metagenomics;goslim_pir;prokaryote_subset molecular_function GO:0016289 acyl-CoA hydrolase activity name acyl-CoA hydrolase activity WAS CoA hydrolase activity synonyms "CoA hydrolase activity" BROAD [] WAS N/A molecular_function GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity name tRNA-queuosine(34) beta-mannosyltransferase activity WAS tRNA-queuosine beta-mannosyltransferase activity synonyms "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.110];"tRNA-queuosine beta-mannosyltransferase activity" BROAD [] WAS "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.110] molecular_function GO:0016491 oxidoreductase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_yeast;prokaryote_subset molecular_function GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. molecular_function GO:0016740 transferase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0016787 hydrolase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset molecular_function GO:0016829 lyase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_yeast;prokaryote_subset molecular_function GO:0016853 isomerase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_pir;goslim_yeast;prokaryote_subset molecular_function GO:0016874 ligase activity subsets goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_yeast;prokaryote_subset molecular_function GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity name short-chain fatty acyl-CoA dehydrogenase activity WAS short-chain-acyl-CoA dehydrogenase activity synonyms "butanoyl-CoA dehydrogenase" NARROW [EC:1.3.8.1];"butyryl dehydrogenase" NARROW [EC:1.3.8.1];"short-chain acyl CoA dehydrogenase" EXACT [EC:1.3.8.1];"short-chain-acyl-CoA dehydrogenase activity" EXACT [];"unsaturated acyl-CoA reductase" BROAD [EC:1.3.8.1] WAS N/A molecular_function GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity name very-long-chain fatty acyl-CoA dehydrogenase activity WAS very-long-chain-acyl-CoA dehydrogenase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A synonyms "very long-chain-acyl-CoA dehydrogenase activity" EXACT [];"very-long-chain acyl-CoA dehydrogenase activity" EXACT [] WAS "very long-chain-acyl-CoA dehydrogenase activity" EXACT [] molecular_function GO:0018814 phenylacetaldoxime dehydratase activity synonyms "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.4];"arylacetaldoxime dehydratase activity" EXACT [EC:4.8.1.4];"PAOx dehydratase activity" RELATED [EC:4.8.1.4] WAS "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" RELATED [EC:4.99.1.7];"(Z)-phenylacetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.7];"arylacetaldoxime dehydratase activity" RELATED [EC:4.99.1.7];"OxdB" RELATED [EC:4.99.1.7];"PAOx dehydratase activity" RELATED [EC:4.99.1.7] molecular_function GO:0031386 protein tag activity subsets goslim_drosophila;goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_drosophila;goslim_generic;goslim_pir;prokaryote_subset molecular_function GO:0031955 short-chain fatty acid-CoA ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0031956 medium-chain fatty acid-CoA ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0031957 very long-chain fatty acid-CoA ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0034013 aliphatic aldoxime dehydratase activity synonyms "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.8.1.2] WAS "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" RELATED [EC:4.99.1.5];"aliphatic aldoxime hydro-lyase activity" RELATED [EC:4.99.1.5];"OxdA" RELATED [EC:4.99.1.5] molecular_function GO:0035380 very long-chain-3-hydroxyacyl-CoA dehydrogenase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0035516 broad specificity oxidative DNA demethylase activity name broad specificity oxidative DNA demethylase activity WAS oxidative DNA demethylase activity comment This reaction directly reverses the alkylation on a nucleotide within DNA. Do not confuse with 5-methylcytosine dioxygenase activity ; GO:0070579, which removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. WAS N/A synonyms "1-ethyladenine demethylase activity" NARROW [];"2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826];"5-formylcytosine dioxygenase activity" NARROW [];"5-hydroxymethylcytosine dioxygenase activity" NARROW [];"5fC dioxygenase" NARROW [];"5hmC dioxygenase" NARROW [];"N1-methyladenine demethylase activity" NARROW [];"N3-methylcytosine demethylase activity" NARROW [];"oxidative DNA demethylase activity" BROAD [] WAS "1-ethyladenine demethylase activity" NARROW [];"2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826];"N1-methyladenine demethylase activity" NARROW [];"N3-methylcytosine demethylase activity" NARROW [] molecular_function GO:0036041 long-chain fatty acid binding definition "Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:pm, PMID:12641450] WAS "Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:pm, PMID:12641450] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0036042 long-chain fatty acyl-CoA binding definition "Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:krc, GOC:pm] WAS "Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons." [GOC:krc, GOC:pm] comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0042393 histone binding subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote;goslim_yeast WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_yeast;prokaryote_subset molecular_function GO:0043399 tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity name tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity WAS tRNA A64-2'-O-ribosylphosphate transferase activity definition "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:22030622, PMID:7954819] WAS "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819] synonyms "initiator tRNA phosphoribosyl-transferase activity" EXACT [];"tRNA A64-2'-O-ribosylphosphate transferase activity" EXACT [] WAS "initiator tRNA phosphoribosyl-transferase activity" EXACT [] molecular_function GO:0043759 2-methylbutanoate-CoA ligase activity name 2-methylbutanoate-CoA ligase activity WAS methylbutanoate-CoA ligase activity molecular_function GO:0044183 protein folding chaperone subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;prokaryote_subset molecular_function GO:0045182 translation regulator activity subsets goslim_candida;goslim_drosophila;goslim_generic;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_candida;goslim_drosophila;goslim_generic;goslim_pir;goslim_plant;prokaryote_subset molecular_function GO:0045735 nutrient reservoir activity subsets goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_generic;goslim_pir;prokaryote_subset molecular_function GO:0047101 branched-chain alpha-keto acid dehydrogenase activity name branched-chain alpha-keto acid dehydrogenase activity WAS 2-oxoisovalerate dehydrogenase (acylating) activity synonyms "2-oxoisovalerate dehydrogenase (acylating) activity" NARROW [EC:1.2.1.25];"2-oxoisovalerate dehydrogenase activity" RELATED [EC:1.2.1.25];"3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" RELATED [EC:1.2.1.25] WAS "2-oxoisovalerate dehydrogenase activity" RELATED [EC:1.2.1.25];"3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" RELATED [EC:1.2.1.25] molecular_function GO:0047450 (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity name (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity WAS (3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity synonyms "(3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity" EXACT [];"3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [];"beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [];"crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [];"crotonoyl-[acyl-carrier-protein] hydratase activity" EXACT [];"crotonoyl-ACP hydratase activity" EXACT [];"crotonoyl-acyl-carrier-protein hydratase activity" EXACT [];"crotonyl acyl carrier protein hydratase activity" EXACT [] WAS "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [];"3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [];"beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [];"crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [];"crotonoyl-[acyl-carrier-protein] hydratase activity" BROAD [];"crotonoyl-ACP hydratase activity" EXACT [];"crotonoyl-acyl-carrier-protein hydratase activity" EXACT [];"crotonyl acyl carrier protein hydratase activity" EXACT [] molecular_function GO:0047474 long-chain fatty acid--protein ligase activity name long-chain fatty acid--protein ligase activity WAS long-chain fatty acid luciferin component ligase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A synonyms "acyl-protein synthetase activity" RELATED [EC:6.2.1.19];"long-chain fatty acid luciferin component ligase activity" EXACT [];"long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah];"long-chain-fatty-acid-luciferin-component ligase activity" EXACT [];"long-chain-fatty-acid:protein ligase (AMP-forming)" RELATED [EC:6.2.1.19] WAS "acyl-protein synthetase activity" RELATED [EC:6.2.1.19];"long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah];"long-chain-fatty-acid-luciferin-component ligase activity" EXACT [];"long-chain-fatty-acid:protein ligase (AMP-forming)" RELATED [EC:6.2.1.19] molecular_function GO:0047617 fatty acyl-CoA hydrolase activity name fatty acyl-CoA hydrolase activity WAS acyl-CoA hydrolase activity synonyms "acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.20];"acyl coenzyme A thioesterase activity" RELATED [EC:3.1.2.20];"acyl-CoA hydrolase activity" BROAD [];"acyl-CoA thioesterase activity" EXACT [];"acyl-CoA thioesterase I activity" NARROW [];"acyl-CoA thioesterase II activity" NARROW [];"acyl-CoA thiolesterase activity" EXACT [];"thioesterase B" RELATED [EC:3.1.2.20];"thioesterase II" RELATED [EC:3.1.2.20] WAS "acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.20];"acyl coenzyme A thioesterase activity" RELATED [EC:3.1.2.20];"acyl-CoA thioesterase activity" EXACT [];"acyl-CoA thioesterase I activity" NARROW [];"acyl-CoA thioesterase II activity" NARROW [];"acyl-CoA thiolesterase activity" EXACT [];"thioesterase B" RELATED [EC:3.1.2.20];"thioesterase II" RELATED [EC:3.1.2.20] subsets goslim_chembl WAS N/A molecular_function GO:0047720 indoleacetaldoxime dehydratase activity synonyms "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.3];"3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3];"indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.8.1.3];"indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3];"indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.8.1.3] WAS "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6];"(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.6];"3-indoleacetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6];"indole-3-acetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.6];"indole-3-acetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6];"indoleacetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6] molecular_function GO:0047904 fructose 5-dehydrogenase activity synonyms "D-fructose dehydrogenase activity" RELATED [EC:1.1.5.14] WAS "D-fructose dehydrogenase activity" RELATED [EC:1.1.99.11];"D-fructose:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.11];"D-fructose:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.11];"fructose 5-dehydrogenase (acceptor)" RELATED [EC:1.1.99.11] molecular_function GO:0050135 NADP+ nucleosidase activity name NADP+ nucleosidase activity WAS NAD(P)+ nucleosidase activity synonyms "NAD(P)+ nucleosidase activity" BROAD [];"NADP nucleosidase activity" EXACT [];"NADP(+) nucleosidase activity" EXACT [];"NADP+ glycohydrolase activity" RELATED [];"NADPase activity" RELATED [] WAS "NAD(P) nucleosidase activity" EXACT [];"NAD(P)(+) nucleosidase activity" EXACT [];"NAD(P)+ glycohydrolase activity" RELATED [EC:3.2.2.6];"NAD(P)ase activity" RELATED [EC:3.2.2.6];"nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" RELATED [EC:3.2.2.6];"nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" RELATED [EC:3.2.2.6];"triphosphopyridine nucleotidase activity" RELATED [EC:3.2.2.6] molecular_function GO:0050421 nitrite reductase (NO-forming) activity comment N/A WAS Note that EC:1.7.99.3 was merged into this term. molecular_function GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity name double-stranded DNA 5'-3' DNA exonuclease activity WAS double-stranded DNA 5'-3' exodeoxyribonuclease activity synonyms "double-stranded DNA 5'-3' exodeoxyribonuclease activity" EXACT [];"double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] WAS "double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] molecular_function GO:0052642 lysophosphatidic acid phosphatase activity synonyms "1-acyl-sn-glycerol 3-phosphatase activity" EXACT [EC:3.1.3.106];"2-lysophosphatidate phosphatase activity" EXACT [EC:3.1.3.106];"LPA phosphatase activity" EXACT [];"lysophosphatidate phosphatase activity" EXACT [] WAS "LPA phosphatase activity" EXACT [];"lysophosphatidate phosphatase activity" EXACT [] molecular_function GO:0052815 medium-chain fatty acyl-CoA hydrolase activity name medium-chain fatty acyl-CoA hydrolase activity WAS medium-chain acyl-CoA hydrolase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A synonyms "medium-chain acyl coenzyme A hydrolase activity" RELATED [];"medium-chain acyl-thioester hydrolase activity" RELATED [];"medium-chain hydrolase activity" RELATED [];"medium-chain-acyl-CoA hydrolase activity" RELATED [] WAS "medium-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19];"medium-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19];"medium-chain hydrolase activity" RELATED [EC:3.1.2.19];"medium-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] molecular_function GO:0052816 long-chain fatty acyl-CoA hydrolase activity name long-chain fatty acyl-CoA hydrolase activity WAS long-chain acyl-CoA hydrolase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A synonyms "long-chain acyl coenzyme A hydrolase activity" RELATED [];"long-chain acyl-thioester hydrolase activity" RELATED [];"long-chain hydrolase activity" RELATED [];"long-chain-acyl-CoA hydrolase activity" RELATED [] WAS "long-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19];"long-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19];"long-chain hydrolase activity" RELATED [EC:3.1.2.19];"long-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] molecular_function GO:0052817 very long-chain fatty acyl-CoA hydrolase activity name very long-chain fatty acyl-CoA hydrolase activity WAS very long chain acyl-CoA hydrolase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A synonyms "very long-chain acyl coenzyme A hydrolase activity" RELATED [];"very long-chain acyl-thioester hydrolase activity" RELATED [];"very long-chain hydrolase activity" RELATED [];"very long-chain-acyl-CoA hydrolase activity" RELATED [] WAS "very long-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19];"very long-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19];"very long-chain hydrolase activity" RELATED [EC:3.1.2.19];"very long-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] molecular_function GO:0060089 molecular transducer activity subsets gocheck_do_not_manually_annotate;goslim_generic;goslim_pir;goslim_prokaryote WAS gocheck_do_not_manually_annotate;goslim_generic;goslim_pir;prokaryote_subset molecular_function GO:0060090 molecular adaptor activity subsets goslim_drosophila;goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_drosophila;goslim_generic;goslim_pir;prokaryote_subset molecular_function GO:0061522 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity definition "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+." [RHEA:26309] WAS "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA." [GOC:dph] molecular_function GO:0061542 3-demethylubiquinol-n 3-O-methyltransferase activity comment Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. WAS N/A molecular_function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating synonyms "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" EXACT [];"NAD hydrolase" NARROW [];"NAD(+) nucleosidase" NARROW [];"NADase" NARROW [];"nicotinamide adenine dinucleotide nucleosidase" NARROW [] WAS N/A molecular_function GO:0070579 5-methylcytosine dioxygenase activity name 5-methylcytosine dioxygenase activity WAS methylcytosine dioxygenase activity comment This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleodides in the DNA. WAS N/A synonyms "methylcytosine dioxygenase activity" BROAD [] WAS N/A molecular_function GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity name medium-chain fatty acyl-CoA dehydrogenase activity WAS medium-chain-acyl-CoA dehydrogenase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0080123 jasmonoyl-L-amino acid ligase activity name jasmonoyl-L-amino acid ligase activity WAS jasmonate-amino synthetase activity synonyms "ja-amino synthetase activity" EXACT [];"jasmonate-amido synthetase activity" EXACT [];"jasmonate-amino acid conjugate synthetase activity" EXACT [];"jasmonate-amino acid synthetase activity" EXACT [];"jasmonate-amino synthetase activity" EXACT [];"jasmonate:amino acid synthetase activity" EXACT [];"jasmonic acid-amino synthetase activity" EXACT [];"jasmonyl-amino synthetase activity" EXACT [] WAS "ja-amino synthetase activity" EXACT [];"jasmonate-amido synthetase activity" EXACT [];"jasmonate-amino acid conjugate synthetase activity" EXACT [];"jasmonate-amino acid synthetase activity" EXACT [];"jasmonate:amino acid synthetase activity" EXACT [];"jasmonic acid-amino synthetase activity" EXACT [];"jasmonyl-amino synthetase activity" EXACT [] molecular_function GO:0090729 toxin activity subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset molecular_function GO:0098631 cell adhesion mediator activity subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset molecular_function GO:0098772 molecular function regulator activity subsets gocheck_do_not_annotate;goslim_flybase_ribbon;goslim_generic;goslim_prokaryote WAS gocheck_do_not_annotate;goslim_flybase_ribbon;goslim_generic;prokaryote_subset molecular_function GO:0102682 cytokinin riboside 5'-monophosphate phosphoribohydrolase activity name cytokinin riboside 5'-monophosphate phosphoribohydrolase activity WAS N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity synonyms "N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity" EXACT [] WAS N/A molecular_function GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0140096 catalytic activity, acting on a protein subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset molecular_function GO:0140097 catalytic activity, acting on DNA subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset molecular_function GO:0140098 catalytic activity, acting on RNA subsets goslim_generic;goslim_prokaryote WAS goslim_generic;prokaryote_subset molecular_function GO:0140104 molecular carrier activity subsets gocheck_do_not_annotate;goslim_generic;goslim_prokaryote WAS gocheck_do_not_annotate;goslim_generic;prokaryote_subset molecular_function GO:0140299 small molecule sensor activity subsets goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_drosophila;goslim_generic;prokaryote_subset molecular_function GO:0140313 molecular sequestering activity subsets goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_drosophila;goslim_generic;prokaryote_subset molecular_function GO:0140657 ATP-dependent activity subsets gocheck_do_not_annotate;goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote;goslim_yeast WAS gocheck_do_not_annotate;goslim_chembl;goslim_drosophila;goslim_generic;goslim_yeast;prokaryote_subset molecular_function GO:0140692 very long-chain fatty acid omega-hydroxylase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A molecular_function GO:0140981 medium-chain fatty acid omega-hydroxylase activity comment While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). WAS N/A cellular_component GO:0005576 extracellular region subsets goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0005615 extracellular space subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;prokaryote_subset cellular_component GO:0005618 cell wall subsets gocheck_do_not_annotate;goslim_candida;goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS gocheck_do_not_annotate;goslim_candida;goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0005694 chromosome subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_pir;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_metagenomics;goslim_pir;goslim_yeast;prokaryote_subset cellular_component GO:0005737 cytoplasm subsets goslim_candida;goslim_chembl;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_metagenomics;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0005840 ribosome subsets goslim_candida;goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_candida;goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0005856 cytoskeleton subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pir;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_flybase_ribbon;goslim_generic;goslim_mouse;goslim_pir;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0005886 plasma membrane subsets goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_plant;goslim_prokaryote;goslim_yeast WAS goslim_agr;goslim_candida;goslim_chembl;goslim_drosophila;goslim_generic;goslim_metagenomics;goslim_mouse;goslim_plant;goslim_yeast;prokaryote_subset cellular_component GO:0009279 cell outer membrane subsets goslim_prokaryote WAS prokaryote_subset cellular_component GO:0009579 thylakoid subsets goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;goslim_prokaryote WAS goslim_chembl;goslim_generic;goslim_metagenomics;goslim_pir;goslim_plant;prokaryote_subset cellular_component GO:0031012 extracellular matrix subsets goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_chembl;goslim_drosophila;goslim_generic;goslim_pir;prokaryote_subset cellular_component GO:0031533 mRNA capping enzyme complex name mRNA capping enzyme complex WAS mRNA cap methyltransferase complex definition "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220, PMID:12455993, PMID:9345280] WAS "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] synonyms N/A WAS "mRNA (guanine-N7) methyltransferase complex" EXACT [];"mRNA capping enzyme complex" EXACT [GOC:vw] cellular_component GO:0039615 T=1 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [VZ:1057] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [UniProtKB-KW:KW-1140, VZ:1057] cellular_component GO:0039616 T=2 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [VZ:838] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [UniProtKB-KW:KW-1141, VZ:838] cellular_component GO:0039617 T=3 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [VZ:806] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1142, VZ:806] cellular_component GO:0039618 T=pseudo3 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [VZ:809] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1143, VZ:809] cellular_component GO:0039619 T=4 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [VZ:808] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [UniProtKB-KW:KW-1144, VZ:808] cellular_component GO:0039620 T=7 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [VZ:804] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [UniProtKB-KW:KW-1145, VZ:804] cellular_component GO:0039621 T=13 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [VZ:260] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [UniProtKB-KW:KW-1146, VZ:260] cellular_component GO:0039622 T=16 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [VZ:807] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [UniProtKB-KW:KW-1147, VZ:807] cellular_component GO:0039623 T=25 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [VZ:810] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [UniProtKB-KW:KW-1148, VZ:810] cellular_component GO:0039628 T=169 icosahedral viral capsid definition "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, VZ:10117] WAS "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1150] cellular_component GO:0042597 periplasmic space subsets goslim_metagenomics;goslim_pir;goslim_prokaryote WAS goslim_metagenomics;goslim_pir;prokaryote_subset cellular_component GO:0042995 cell projection subsets goslim_agr;goslim_flybase_ribbon;goslim_mouse;goslim_pir;goslim_prokaryote WAS goslim_agr;goslim_flybase_ribbon;goslim_mouse;goslim_pir;prokaryote_subset cellular_component GO:0043226 organelle subsets goslim_chembl;goslim_generic;goslim_pir;goslim_prokaryote WAS goslim_chembl;goslim_generic;goslim_pir;prokaryote_subset cellular_component GO:0043590 bacterial nucleoid subsets goslim_prokaryote WAS prokaryote_subset cellular_component GO:0098015 virus tail definition "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm, VZ:3958] WAS "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm] cellular_component GO:0098021 viral capsid, decoration definition "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm, VZ:4398] WAS "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm] cellular_component GO:0098024 virus tail, fiber definition "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm, VZ:4416] WAS "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm] cellular_component GO:0098025 virus tail, baseplate definition "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm, VZ:3957] WAS "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm] cellular_component GO:0098026 virus tail, tube definition "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm, VZ:3960] WAS "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm] cellular_component GO:0098027 virus tail, sheath definition "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm, VZ:3959] WAS "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm] cellular_component GO:0120330 rixosome complex synonyms "rix1 complex" NARROW [] WAS N/A 225 CROSS REFERENCES CHANGES molecular_function GO:0000104 succinate dehydrogenase activity xrefs KEGG_REACTION:R00412;RHEA:16357 WAS KEGG:R00412;RHEA:16357 molecular_function GO:0000170 sphingosine hydroxylase activity xrefs Reactome:R-HSA-428260 "DEGS2 oxygenates dihydroceramide" WAS Reactome:R-HSA-428260 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O" molecular_function GO:0000175 3'-5'-RNA exonuclease activity xrefs EC:3.1.13.-;Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion";Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA";Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA";Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA";Reactome:R-HSA-9694632 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA";Reactome:R-HSA-9822437 "DIS3L2 hydrolyzes uridylated mRNA";Reactome:R-HSA-9836585 "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides";Reactome:R-HSA-9836822 "REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides" WAS EC:3.1.13.-;Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion";Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA";Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA";Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA";Reactome:R-HSA-9694632 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA" molecular_function GO:0000386 second spliceosomal transesterification activity xrefs Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation" WAS Reactome:R-HSA-9770236 "Formation of the Spliceosomal P complex and exon ligation (new)" molecular_function GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity xrefs EC:2.4.3.3;MetaCyc:2.4.99.3-RXN;Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)";Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG";Reactome:R-HSA-9846305 "ST6GALNAC5,6 transfer Neu5Ac to GM1b";RHEA:11136 WAS EC:2.4.3.3;MetaCyc:2.4.99.3-RXN;Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)";Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG";RHEA:11136 molecular_function GO:0001727 lipid kinase activity xrefs Reactome:R-HSA-428273 "SPHK1 phosphorylates sphingoid";Reactome:R-HSA-9695949 "SPHK2 phosphorylates sphingoid" WAS N/A molecular_function GO:0001733 galactosylceramide sulfotransferase activity xrefs EC:2.8.2.11;MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN;Reactome:R-HSA-9844587 "GAL3ST1 transfers sulfate to GalCer,LacCer";RHEA:20613 WAS EC:2.8.2.11;MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN;RHEA:20613 molecular_function GO:0002151 G-quadruplex RNA binding xrefs Reactome:R-HSA-9836998 "GRSF1 unwinds quadruplex G regions in RNA" WAS N/A molecular_function GO:0002950 ceramide phosphoethanolamine synthase activity xrefs EC:2.7.8.n3;Reactome:R-HSA-8959462 "SAMD8 transfers phosphatidyl from PE onto C16DH CER" WAS EC:2.7.8.n3;Reactome:R-HSA-8959462 "SAMD8 transforms PE and CERA to CPE" molecular_function GO:0003724 RNA helicase activity xrefs EC:3.6.4.13;MetaCyc:RXN-11109;Reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases";Reactome:R-HSA-9770129 "Formation of the Spliceosomal A complex";Reactome:R-HSA-9770131 "Formation of the Spliceosomal B* complex";Reactome:R-HSA-9770141 "Formation of the Spliceosomal C* complex";Reactome:R-HSA-9770142 "Formation of the Spliceosomal B complex";Reactome:R-HSA-9770145 "Formation of the Spliceosomal Bact complex" WAS EC:3.6.4.13;MetaCyc:RXN-11109;Reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases";Reactome:R-HSA-9770129 "Formation of the Spliceosomal A complex (update)";Reactome:R-HSA-9770131 "Formation of the Spliceosomal B* complex (new)";Reactome:R-HSA-9770141 "Formation of the Spliceosomal C* complex (update)";Reactome:R-HSA-9770142 "Formation of the Spliceosomal B complex (new)";Reactome:R-HSA-9770145 "Formation of the Spliceosomal Bact complex (new)" molecular_function GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity xrefs EC:2.4.3.8;MetaCyc:2.4.99.8-RXN;Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues";Reactome:R-HSA-422454 "Polysialylation of NCAM1";Reactome:R-HSA-9845587 "ST8SIA5 transfers Neu5Ac to gangliosides";RHEA:19313 WAS EC:2.4.3.8;MetaCyc:2.4.99.8-RXN;Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues";Reactome:R-HSA-422454 "Polysialylation of NCAM1";RHEA:19313 molecular_function GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity xrefs EC:2.4.3.4;MetaCyc:2.4.99.4-RXN;Reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH";Reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid";Reactome:R-HSA-3656258 "Defective ST3GAL3 does not transfer SA to keratan";Reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)";Reactome:R-HSA-9603987 "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG";Reactome:R-HSA-9605600 "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG";Reactome:R-HSA-981497 "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position";Reactome:R-HSA-9844860 "ST3GAL5 transfers NeuNAc to ceramides";Reactome:R-HSA-9845538 "ST3GAL2,3 transfer Neu5Ac to gangliosides";RHEA:21616 WAS EC:2.4.3.4;MetaCyc:2.4.99.4-RXN;Reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH";Reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid";Reactome:R-HSA-3656258 "Defective ST3GAL3 does not transfer SA to keratan";Reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)";Reactome:R-HSA-9603987 "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG";Reactome:R-HSA-9605600 "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG";Reactome:R-HSA-981497 "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position";RHEA:21616 molecular_function GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity xrefs EC:2.4.1.92;MetaCyc:2.4.1.92-RXN;Reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc to gangliosides";RHEA:12588 WAS EC:2.4.1.92;MetaCyc:2.4.1.92-RXN;Reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides";RHEA:12588 molecular_function GO:0003953 NAD+ nucleosidase activity xrefs EC:3.2.2.5;MetaCyc:RXN-13859;Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose";Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose";RHEA:16301 WAS Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose";Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose";RHEA:16301 molecular_function GO:0003968 RNA-dependent RNA polymerase activity xrefs EC:2.7.7.48;MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN;Reactome:R-HSA-168280 "Priming and Initiation of Transcription";Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination";Reactome:R-HSA-192624 "cRNA Extension";Reactome:R-HSA-192832 "Initiation of cRNA Synthesis";Reactome:R-HSA-192851 "vRNA Extension";Reactome:R-HSA-192916 "Initiation of vRNA Synthesis";Reactome:R-HSA-9681651 "nsp8 generates RNA primers";Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement";Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA";Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs";Reactome:R-HSA-9694277 "nsp8 generates RNA primers";Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs";Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA";Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement";Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9828639 "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs";Reactome:R-HSA-9834719 "Synthesis of negative sense genomic RNA of respiratory syncytial virus";Reactome:R-HSA-9834736 "Synthesis of antigenomic RNA of human respiratory syncytial virus";Reactome:R-HSA-9837511 "Abortive replication of hRSV A" WAS EC:2.7.7.48;MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN;Reactome:R-HSA-168280 "Priming and Initiation of Transcription";Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination";Reactome:R-HSA-192624 "cRNA Extension";Reactome:R-HSA-192832 "Initiation of cRNA Synthesis";Reactome:R-HSA-192851 "vRNA Extension";Reactome:R-HSA-192916 "Initiation of vRNA Synthesis";Reactome:R-HSA-9681651 "nsp8 generates RNA primers";Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement";Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA";Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs";Reactome:R-HSA-9694277 "nsp8 generates RNA primers";Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs";Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA";Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement";Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand" molecular_function GO:0003995 acyl-CoA dehydrogenase activity xrefs MetaCyc:ACYLCOADEHYDROG-RXN;MetaCyc:RXN-13624;Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA";Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA";Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA";Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2";Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2";Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2";Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2";Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2";Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2";Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2";RHEA:44704 WAS MetaCyc:ACYLCOADEHYDROG-RXN;Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA";Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA";Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA";Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2";Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2";Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2";Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2";Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2";Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2";Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2";RHEA:44704 molecular_function GO:0004085 butyryl-CoA dehydrogenase activity xrefs KEGG_REACTION:R01178;MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN;RHEA:24004;UM-BBD_reactionID:r0013 WAS EC:1.3.8.1;KEGG_REACTION:R01178;MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN;RHEA:24004;UM-BBD_reactionID:r0013 molecular_function GO:0004098 cerebroside-sulfatase activity xrefs EC:3.1.6.8;MetaCyc:CEREBROSIDE-SULFATASE-RXN;Reactome:R-HSA-1606807 "ARSA removes sulfate from PSAP(195-273):Sulfatide";Reactome:R-HSA-9840949 "ARSA removes sulfate from SM3";RHEA:21300 WAS EC:3.1.6.8;MetaCyc:CEREBROSIDE-SULFATASE-RXN;Reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside";RHEA:21300 molecular_function GO:0004126 cytidine deaminase activity xrefs EC:3.5.4.5;MetaCyc:CYTIDEAM2-RXN;Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)";Reactome:R-HSA-83677 "C4 deamination of cytidine";Reactome:R-HSA-9817513 "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine";RHEA:16069 WAS EC:3.5.4.5;MetaCyc:CYTIDEAM2-RXN;Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)";Reactome:R-HSA-83677 "C4 deamination of cytidine";RHEA:16069 molecular_function GO:0004140 dephospho-CoA kinase activity xrefs EC:2.7.1.24;KEGG_REACTION:R00130;MetaCyc:DEPHOSPHOCOAKIN-RXN;Reactome:R-HSA-196773 "COASY phosphorylates DP-CoA";Reactome:R-HSA-9837337 "DCAKD phosphorylates DP-CoA";RHEA:18245 WAS EC:2.7.1.24;KEGG_REACTION:R00130;MetaCyc:DEPHOSPHOCOAKIN-RXN;Reactome:R-HSA-196773 "COASY phosphorylates DP-CoA";RHEA:18245 molecular_function GO:0004164 diphthine synthase activity xrefs EC:2.1.1.98;MetaCyc:RXN-14326;Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2";RHEA:36415 WAS EC:2.1.1.98;MetaCyc:RXN-11370;Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2";RHEA:36415 molecular_function GO:0004176 ATP-dependent peptidase activity xrefs Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex";Reactome:R-HSA-9838004 "LONP1 degrades mitochondrial inner membrane proteins";Reactome:R-HSA-9838081 "LONP1 degrades mitochondrial matrix proteins";Reactome:R-HSA-9838289 "CLPXP degrades mitochondrial matrix proteins";Reactome:R-HSA-9839059 "AFG3L2:SPG7 degrades SMDT1 (EMRE)";Reactome:R-HSA-9839105 "AFG3L2 degrades mitochondrial matrix proteins";Reactome:R-HSA-9839113 "AFG3L2 degrades mitochondrial inner membrane proteins";Reactome:R-HSA-9839146 "YME1L1 degrades mitochondrial inner membrane proteins";Reactome:R-HSA-9839751 "YME1L1 degrades mitochondrial intermembrane space proteins" WAS Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex" molecular_function GO:0004222 metalloendopeptidase activity xrefs EC:3.4.24.-;Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";Reactome:R-HSA-2022141 "Prolysyl oxidase activation";Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";Reactome:R-HSA-2514790 "Elastin degradation by MMP14";Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6";Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";Reactome:R-HSA-2537499 "Gelatin degradation by MMP19";Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";Reactome:R-HSA-3791319 "NID1 degradation by MMP19";Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";Reactome:R-HSA-5333671 "CLCAs self cleave";Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";Reactome:R-HSA-8940554 "MMP2 cleaves OPTC";Reactome:R-HSA-8940561 "MMP7 cleaves OPTC";Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";Reactome:R-HSA-8942302 "MMP13 cleaves OPTC";Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1";Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";Reactome:R-HSA-9840532 "OMA1 self-cleaves";Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer" WAS EC:3.4.24.-;Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";Reactome:R-HSA-2022141 "Prolysyl oxidase activation";Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";Reactome:R-HSA-2514790 "Elastin degradation by MMP14";Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6";Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";Reactome:R-HSA-2537499 "Gelatin degradation by MMP19";Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";Reactome:R-HSA-3791319 "NID1 degradation by MMP19";Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";Reactome:R-HSA-5333671 "CLCAs self cleave";Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";Reactome:R-HSA-8940554 "MMP2 cleaves OPTC";Reactome:R-HSA-8940561 "MMP7 cleaves OPTC";Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";Reactome:R-HSA-8942302 "MMP13 cleaves OPTC";Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1";Reactome:R-HSA-9624272 "MMPs cleave HB-EGF" molecular_function GO:0004252 serine-type endopeptidase activity xrefs EC:3.4.21.-;Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them";Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein";Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage";Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides";Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)";Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide";Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)";Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140769 "factor VII -> factor VIIa";Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)";Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B";Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin";Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form";Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C";Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin.";Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2";Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases";Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases";Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS";Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer";Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)";Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)";Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin";Reactome:R-HSA-158313 "factor XII -> factor XIIa";Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)";Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)";Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin";Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)";Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin";Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)";Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)";Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)";Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE";Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2";Reactome:R-HSA-1592297 "Full activation of MMP1";Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)";Reactome:R-HSA-1592316 "Initial activation of proMMP1";Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3";Reactome:R-HSA-1592371 "Initial activation of proMMP3";Reactome:R-HSA-1592398 "Activation of proMMP8";Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs";Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin";Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X";Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C";Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S";Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX";Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII";Reactome:R-HSA-1602458 "Activation of proMMP10";Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN";Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1";Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN";Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin";Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7";Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14";Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2";Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs";Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin";Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases";Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3";Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13";Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)";Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3";Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7";Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z";Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6";Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b";Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b";Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases";Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN";Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein";Reactome:R-HSA-173626 "Activation of C1r";Reactome:R-HSA-173631 "Activation of C1s";Reactome:R-HSA-173680 "Activation of C5";Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B";Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase";Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein";Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B";Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a";Reactome:R-HSA-186785 "PDGF-AA clevage by Furin";Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF";Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH";Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN";Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)";Reactome:R-HSA-2129357 "Fibrillin C-terminal processing";Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release";Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding";Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding";Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1";Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins";Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding";Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE";Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2";Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE";Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS";Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)";Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1";Reactome:R-HSA-265301 "Corticotropin cleavage from POMC";Reactome:R-HSA-3266557 "Factor I cleaves iC3b";Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG";Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8";Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS";Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1";Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1";Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs";Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB";Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1";Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP";Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP";Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin";Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin";Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)";Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va";Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa";Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein";Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer";Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)";Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP";Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5";Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2";Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8";Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5";Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)";Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin";Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin";Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4";Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3";Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2";Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3";Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1";Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))";Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)";Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH";Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS";Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1";Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1";Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2";Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1";Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4";Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin";Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1";Reactome:R-HSA-9662786 "FURIN cleaves ADAM17";Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin";Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L";Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa";Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa";Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)";Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid";Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it";Reactome:R-HSA-9710106 "ELANE cleaves GSDMD";Reactome:R-HSA-9710263 "GZMB cleaves GSDME";Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b";Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage";Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion";Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b";Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b";Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane";Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)";Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated";Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane" WAS EC:3.4.21.-;Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them";Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein";Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage";Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides";Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)";Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide";Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)";Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140769 "factor VII -> factor VIIa";Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)";Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B";Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin";Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form";Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C";Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin.";Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2";Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases";Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases";Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS";Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer";Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)";Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)";Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin";Reactome:R-HSA-158313 "factor XII -> factor XIIa";Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)";Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)";Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin";Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)";Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin";Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)";Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)";Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)";Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE";Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2";Reactome:R-HSA-1592297 "Full activation of MMP1";Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)";Reactome:R-HSA-1592316 "Initial activation of proMMP1";Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3";Reactome:R-HSA-1592371 "Initial activation of proMMP3";Reactome:R-HSA-1592398 "Activation of proMMP8";Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs";Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin";Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X";Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C";Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S";Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX";Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII";Reactome:R-HSA-1602458 "Activation of proMMP10";Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN";Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1";Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN";Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin";Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7";Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14";Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2";Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs";Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin";Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases";Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3";Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13";Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)";Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3";Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7";Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z";Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6";Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b";Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b";Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases";Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN";Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein";Reactome:R-HSA-173626 "Activation of C1r";Reactome:R-HSA-173631 "Activation of C1s";Reactome:R-HSA-173680 "Activation of C5";Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B";Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase";Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein";Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B";Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a";Reactome:R-HSA-186785 "PDGF-AA clevage by Furin";Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF";Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH";Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN";Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)";Reactome:R-HSA-2129357 "Fibrillin C-terminal processing";Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release";Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding";Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding";Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1";Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins";Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding";Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE";Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2";Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE";Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS";Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)";Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1";Reactome:R-HSA-265301 "Corticotropin cleavage from POMC";Reactome:R-HSA-3266557 "Factor I cleaves iC3b";Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG";Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8";Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS";Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1";Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1";Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs";Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB";Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1";Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP";Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP";Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin";Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin";Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)";Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va";Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa";Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein";Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer";Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)";Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP";Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5";Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2";Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8";Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5";Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)";Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin";Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin";Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4";Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3";Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2";Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3";Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1";Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))";Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)";Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH";Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS";Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1";Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1";Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2";Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1";Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4";Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin";Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1";Reactome:R-HSA-9662786 "FURIN cleaves ADAM17";Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin";Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L";Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa";Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa";Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)";Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid";Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it";Reactome:R-HSA-9710106 "ELANE cleaves GSDMD";Reactome:R-HSA-9710263 "GZMB cleaves GSDME";Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b";Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage";Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion";Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b";Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" molecular_function GO:0004298 threonine-type endopeptidase activity xrefs EC:3.4.25.-;Reactome:R-HSA-9818574 "TASP1 cleaves KMT2A";Reactome:R-HSA-9818577 "TASP1 cleaves KMT2B" WAS EC:3.4.25.- molecular_function GO:0004308 exo-alpha-sialidase activity xrefs EC:3.2.1.18;MetaCyc:3.2.1.18-RXN;Reactome:R-HSA-1605723 "NEU2 cleaves GM3 to form LacCer (cytosol)";Reactome:R-HSA-1605724 "NEU1,4 hydrolyze PSAP(195-273):GM3:PE";Reactome:R-HSA-1605768 "NEU3 cleaves GM3 to form LacCer (plasma membrane)";Reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid";Reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates";Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates";Reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates";Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates";Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates" WAS EC:3.2.1.18;MetaCyc:3.2.1.18-RXN;Reactome:R-HSA-1605723 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)";Reactome:R-HSA-1605724 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)";Reactome:R-HSA-1605768 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)";Reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid";Reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates";Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates";Reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates";Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates";Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates" molecular_function GO:0004317 (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity xrefs KEGG_REACTION:R04462;RHEA:41908 WAS KEGG_REACTION:R04462;MetaCyc:4.2.1.61-RXN;RHEA:41908 molecular_function GO:0004336 galactosylceramidase activity xrefs EC:3.2.1.46;MetaCyc:GALACTOSYLCERAMIDASE-RXN;Reactome:R-HSA-1606564 "GALC hydrolyzes GalCer";RHEA:14297 WAS EC:3.2.1.46;MetaCyc:GALACTOSYLCERAMIDASE-RXN;Reactome:R-HSA-1606564 "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide";RHEA:14297 molecular_function GO:0004340 glucokinase activity xrefs EC:2.7.1.2;MetaCyc:GLUCOKIN-RXN;Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P";Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P";Reactome:R-HSA-70420 "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P";RHEA:17825 WAS EC:2.7.1.2;MetaCyc:GLUCOKIN-RXN;Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P";Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P";Reactome:R-HSA-70420 "HK1,2,3,GCK phosphorylate Glc to form G6P";RHEA:17825 molecular_function GO:0004348 glucosylceramidase activity xrefs EC:3.2.1.45;MetaCyc:GLUCOSYLCERAMIDASE-RXN;Reactome:R-HSA-1605591 "GBA1:SAPC hydrolyzes GlcCer";Reactome:R-HSA-1861788 "GBA2 hydrolyzes GlcCer (plasma membrane)";Reactome:R-HSA-1861789 "GBA3 hydrolyzes GlcCer (cytosol)";RHEA:13269 WAS EC:3.2.1.45;MetaCyc:GLUCOSYLCERAMIDASE-RXN;Reactome:R-HSA-1605591 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide";Reactome:R-HSA-1861788 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)";Reactome:R-HSA-1861789 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)";RHEA:13269 molecular_function GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity xrefs EC:2.1.1.56;MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN;Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase";Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";Reactome:R-HSA-9830848 "L protein acts as a cap N7 methyltransferase to modify RSV mRNAs" WAS EC:2.1.1.56;MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN;Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase";Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)" molecular_function GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity xrefs EC:2.1.1.57;MetaCyc:2.1.1.57-RXN;Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs" WAS EC:2.1.1.57;MetaCyc:2.1.1.57-RXN;Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)" molecular_function GO:0004497 monooxygenase activity xrefs Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde";Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO";Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone";Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA";Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation";Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2";Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA";Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole";Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide";Reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b";Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST";Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA";Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM";Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL";Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation";Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6";Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation";Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole";Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO";Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4";Reactome:R-HSA-2161795 "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)";Reactome:R-HSA-2161814 "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)";Reactome:R-HSA-2161890 "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)";Reactome:R-HSA-2161899 "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)";Reactome:R-HSA-2161940 "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)";Reactome:R-HSA-2162191 "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase";Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ";Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E";Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1";Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO";Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1";Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA";Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3";Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3";Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b";Reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone";Reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR";Reactome:R-HSA-5663050 "DHI and DHICA polymerize forming eumelanin";Reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE";Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide";Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl";Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP";Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)";Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol";Reactome:R-HSA-76426 "N-atom dealkylation of caffeine";Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical";Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan";Reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX";Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1";Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide";Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2";Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE";Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1";Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA";Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2";Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA";Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA";Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1";Reactome:R-HSA-9749986 "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA";Reactome:R-HSA-9750016 "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA";Reactome:R-HSA-9753285 "CYP2E1 monooxygenates APAP to NAPQI";Reactome:R-HSA-9756138 "CYP3A4 monooxygenates ATVL to 2-OH-ATVL";Reactome:R-HSA-9756162 "CYP3A4 monooxygenates ATV to 4-OH-ATV";Reactome:R-HSA-9756169 "CYP3A4 monooxygenates ATV to 2-OH-ATV";Reactome:R-HSA-9756180 "CYP3A4 monooxygenates ATVL to 4-OH-ATVL" WAS Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde";Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO";Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone";Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA";Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation";Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2";Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA";Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole";Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide";Reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b";Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST";Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA";Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM";Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL";Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation";Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6";Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation";Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole";Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO";Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4";Reactome:R-HSA-2161795 "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)";Reactome:R-HSA-2161814 "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)";Reactome:R-HSA-2161890 "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)";Reactome:R-HSA-2161899 "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)";Reactome:R-HSA-2161940 "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)";Reactome:R-HSA-2162191 "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase";Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ";Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E";Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1";Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO";Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1";Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA";Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3";Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3";Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b";Reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone";Reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR";Reactome:R-HSA-5663050 "DHI and DHICA polymerise forming eumelanin";Reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE";Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide";Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl";Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP";Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)";Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol";Reactome:R-HSA-76426 "N-atom dealkylation of caffeine";Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical";Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan";Reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX";Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1";Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide";Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2";Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE";Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1";Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA";Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2";Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA";Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA";Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1";Reactome:R-HSA-9749986 "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA";Reactome:R-HSA-9750016 "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA";Reactome:R-HSA-9753285 "CYP2E1 monooxygenates APAP to NAPQI";Reactome:R-HSA-9756138 "CYP3A4 monooxygenates ATVL to 2-OH-ATVL";Reactome:R-HSA-9756162 "CYP3A4 monooxygenates ATV to 4-OH-ATV";Reactome:R-HSA-9756169 "CYP3A4 monooxygenates ATV to 2-OH-ATV";Reactome:R-HSA-9756180 "CYP3A4 monooxygenates ATVL to 4-OH-ATVL" molecular_function GO:0004525 ribonuclease III activity xrefs EC:3.1.26.3;MetaCyc:3.1.26.3-RXN;Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA";Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA";Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA";Reactome:R-HSA-9708292 "DICER1 cleaves tRNA";Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid";Reactome:R-HSA-9820840 "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA" WAS EC:3.1.26.3;MetaCyc:3.1.26.3-RXN;Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA";Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA";Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA";Reactome:R-HSA-9708292 "DICER1 cleaves tRNA";Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid" molecular_function GO:0004535 poly(A)-specific ribonuclease activity xrefs EC:3.1.13.4;MetaCyc:3.1.13.4-RXN;Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA";Reactome:R-HSA-429992 "PARN deadenylates mRNA";Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA";Reactome:R-HSA-9822311 "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP";Reactome:R-HSA-9822335 "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA" WAS EC:3.1.13.4;MetaCyc:3.1.13.4-RXN;Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA";Reactome:R-HSA-429992 "PARN deadenylates mRNA";Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA" molecular_function GO:0004557 alpha-galactosidase activity xrefs EC:3.2.1.22;MetaCyc:ALPHAGALACTOSID-RXN;Reactome:R-HSA-1605736 "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE";Reactome:R-HSA-9841189 "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE" WAS EC:3.2.1.22;MetaCyc:ALPHAGALACTOSID-RXN;Reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers" molecular_function GO:0004563 beta-N-acetylhexosaminidase activity xrefs EC:3.2.1.52;MetaCyc:3.2.1.52-RXN;Reactome:R-HSA-1605595 "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3";Reactome:R-HSA-1605632 "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE";Reactome:R-HSA-1638053 "HEXA cleaves the terminal GalNAc from keratan sulfate";Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS";Reactome:R-HSA-2162225 "HEXA cleaves the terminal GalNAc from small HA fragments";Reactome:R-HSA-3656259 "Defective HEXA does not cleave the terminal GalNAc from DS";Reactome:R-HSA-3662344 "Defective HEXB does not cleave the terminal GalNAc from DS";Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments";Reactome:R-HSA-9035978 "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate";Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments";Reactome:R-HSA-9035983 "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate";Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS";Reactome:R-HSA-9638076 "HEXB cleaves the terminal GalNAc from small HA fragments";Reactome:R-HSA-9638078 "HEXB cleaves the terminal GalNAc from keratan sulfate";Reactome:R-HSA-9840833 "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer";Reactome:R-HSA-9840884 "bHEXA,bHEXS hydrolyze GM2A:SM2" WAS EC:3.2.1.52;MetaCyc:3.2.1.52-RXN;Reactome:R-HSA-1605595 "Hexosaminidase A cleaves GalNAc from GM2 to form GM3";Reactome:R-HSA-1605632 "Both hexosaminidase A and B can cleave GalNAc from globoside";Reactome:R-HSA-1638053 "HEXA cleaves the terminal GalNAc from keratan sulfate";Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS";Reactome:R-HSA-2162225 "HEXA cleaves the terminal GalNAc from small HA fragments";Reactome:R-HSA-3656259 "Defective HEXA does not cleave the terminal GalNAc from DS";Reactome:R-HSA-3662344 "Defective HEXB does not cleave the terminal GalNAc from DS";Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments";Reactome:R-HSA-9035978 "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate";Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments";Reactome:R-HSA-9035983 "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate";Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS";Reactome:R-HSA-9638076 "HEXB cleaves the terminal GalNAc from small HA fragments";Reactome:R-HSA-9638078 "HEXB cleaves the terminal GalNAc from keratan sulfate" molecular_function GO:0004565 beta-galactosidase activity xrefs EC:3.2.1.23;MetaCyc:3.2.1.23-RXN;MetaCyc:BGALACT-PWY;Reactome:R-HSA-1605624 "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2";Reactome:R-HSA-1606312 "GLB1 hydrolyzes SapB/C:LacCer";Reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan";Reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase";Reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)";Reactome:R-HSA-2265534 "Defective GLB1 does not hydrolyse a glycosaminoglycan";Reactome:R-HSA-9036061 "Defective GLB1 does not hydrolyse linker chain(2)";Reactome:R-HSA-9840795 "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2" WAS EC:3.2.1.23;MetaCyc:3.2.1.23-RXN;MetaCyc:BGALACT-PWY;Reactome:R-HSA-1605624 "Beta-galactosidase hydrolyses GM1 to GM2";Reactome:R-HSA-1606312 "Beta-galactosidase can also hydrolyse globosides to form cerebrosides";Reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan";Reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase";Reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)";Reactome:R-HSA-2265534 "Defective GLB1 does not hydrolyse a glycosaminoglycan";Reactome:R-HSA-9036061 "Defective GLB1 does not hydrolyse linker chain(2)" molecular_function GO:0004594 pantothenate kinase activity xrefs EC:2.7.1.33;MetaCyc:PANTOTHENATE-KIN-RXN;Reactome:R-HSA-196857 "PANK2 phosphorylates PanK";Reactome:R-HSA-199203 "PANK1/3 phosphorylate PanK";RHEA:16373 WAS EC:2.7.1.33;MetaCyc:PANTOTHENATE-KIN-RXN;Reactome:R-HSA-196857 "PANK2 phosphorylates PanK";Reactome:R-HSA-199203 "PANK1/3/4 phosphorylate PanK";RHEA:16373 molecular_function GO:0004672 protein kinase activity xrefs Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a";Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino";Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4";Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation";Reactome:R-HSA-9732753 "JAK1-activated RAF1 phosphorylates MAPKs";Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation";Reactome:R-HSA-9833820 "PKR dimer autophosphorylates";Reactome:R-HSA-9835885 "p-PKR dimer phosphorylates eIF2-alpha";Reactome:R-HSA-9836159 "p-PKR dimer phosphorylates DHX9";Reactome:R-HSA-9836184 "p-PKR dimer phosphorylates CDK1";Reactome:R-HSA-9836322 "p-PKR dimer phosphorylates MKK6";Reactome:R-HSA-9836362 "p-PKR dimer phosphorylates TP53 tetramer";Reactome:R-HSA-9836383 "p-PKR dimer phosphorylates ILF3:ILF2";Reactome:R-HSA-9836404 "p-PKR dimer phosphorylates MAPT";Reactome:R-HSA-9836435 "p-PKR dimer phosphorylates SNCA";Reactome:R-HSA-9836449 "p-PKR dimer phosphorylates HIV tat";Reactome:R-HSA-9836515 "p-PKR dimer phosphorylates PTPN2";Reactome:R-HSA-9836617 "p-PKR dimer phosphorylates SPHK1";Reactome:R-HSA-9836664 "p-PKR dimer phosphorylates PPP2R5A" WAS Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a";Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino";Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4";Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation";Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" molecular_function GO:0004674 protein serine/threonine kinase activity xrefs EC:2.7.11.1;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes";Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes";Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-451347 "Activation of JNK by DSCAM";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1";Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2";Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357";Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P";Reactome:R-HSA-9831712 "M dimer is phosphorylated";Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated" WAS EC:2.7.11.1;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes";Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes";Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-451347 "Activation of JNK by DSCAM";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1";Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357" molecular_function GO:0004679 AMP-activated protein kinase activity xrefs EC:2.7.11.11;Reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A";Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 556 by AMPK";Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis";Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2";Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex";Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex";Reactome:R-HSA-6805470 "AMPK phosphorylates TP53" WAS EC:2.7.11.11;Reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A";Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK";Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis";Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2";Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex";Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex";Reactome:R-HSA-6805470 "AMPK phosphorylates TP53" molecular_function GO:0004691 cAMP-dependent protein kinase activity xrefs EC:2.7.11.11;Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(653) by PKA";Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA";Reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit";Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34";Reactome:R-HSA-177284 "PKA phosphorylates PDE4B";Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)";Reactome:R-HSA-5610717 "PKA phosphorylates GLI2";Reactome:R-HSA-5610720 "PKA phosphorylates GLI3";Reactome:R-HSA-5610741 "PKA phosphorylates GLI1";Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3";Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN";Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5";Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585";Reactome:R-HSA-9838321 "PRKACA phosphorylates TFAM in the mitochondrial matrix" WAS EC:2.7.11.11;Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(666) by PKA";Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA";Reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit";Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34";Reactome:R-HSA-177284 "PKA phosphorylates PDE4B";Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)";Reactome:R-HSA-5610717 "PKA phosphorylates GLI2";Reactome:R-HSA-5610720 "PKA phosphorylates GLI3";Reactome:R-HSA-5610741 "PKA phosphorylates GLI1";Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3";Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN";Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5";Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585" molecular_function GO:0004697 diacylglycerol-dependent serine/threonine kinase activity xrefs EC:2.7.11.13;Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT";Reactome:R-HSA-193703 "IKKbeta is activated";Reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta";Reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3";Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta";Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin";Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates CERT1-2";Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR";Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR";Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC";Reactome:R-HSA-5218805 "PKC autophosphorylates";Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1";Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation";Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP";Reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)";Reactome:R-HSA-8932284 "PKC phosphorylates NFE2L2";Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1";Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1";Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727";Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";Reactome:R-HSA-9626817 "PKC phosphorylates NCF1";Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation";Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2" WAS EC:2.7.11.13;Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT";Reactome:R-HSA-193703 "IKKbeta is activated";Reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta";Reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3";Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta";Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin";Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates CERT1-2";Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR";Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR";Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC";Reactome:R-HSA-5218805 "PKC autophosphorylates";Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1";Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation";Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP";Reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)";Reactome:R-HSA-8932284 "PKC phosphorylates NFE2L2";Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1";Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1";Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727";Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";Reactome:R-HSA-9626817 "PKC phosphorylates NCF1";Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation" molecular_function GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity xrefs Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1";Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4";Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites";Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors";Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308";Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308" WAS Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1";Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4";Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites";Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors" molecular_function GO:0004713 protein tyrosine kinase activity xrefs Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1";Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma";Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation";Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers";Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers";Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer";Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers";Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers";Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers";Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2";Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5";Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227";Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4";Reactome:R-HSA-1433418 "Phosphorylation of JAK2";Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs";Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs";Reactome:R-HSA-1433506 "Phosphorylation of APS";Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1";Reactome:R-HSA-1470009 "Phosphorylation of STATs";Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases";Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR";Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated";Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes";Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes";Reactome:R-HSA-170991 "SRC-1 autophosphorylates";Reactome:R-HSA-171011 "Binding and activation of MAP Kinase";Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15";Reactome:R-HSA-177934 "EGFR autophosphorylation";Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase";Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)";Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)";Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers";Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1";Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1";Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2";Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions";Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors";Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3";Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4";Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b";Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c";Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b";Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c";Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b";Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c";Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c";Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src";Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers";Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers";Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2";Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1";Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant";Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants";Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant";Reactome:R-HSA-201521 "ALK autophosphorylation";Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes";Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck";Reactome:R-HSA-202174 "Activation of ZAP-70";Reactome:R-HSA-202216 "Phosphorylation of SLP-76";Reactome:R-HSA-202233 "Inactivation of Lck by Csk";Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT";Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1";Reactome:R-HSA-202291 "Activation of Lck";Reactome:R-HSA-202307 "Change of PKC theta conformation";Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers";Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity";Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG";Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases";Reactome:R-HSA-2029453 "Phosphorylation of VAV";Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts";Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants";Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants";Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity";Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding";Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding";Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity";Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants";Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity";Reactome:R-HSA-205289 "Autophosphorylation of KIT";Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src";Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2";Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation";Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs";Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP";Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK";Reactome:R-HSA-2395412 "Phosphorylation of SYK";Reactome:R-HSA-2395439 "Phosphorylation of DAP12";Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1";Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates";Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK";Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK";Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK";Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4";Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN";Reactome:R-HSA-2454239 "Phosphorylation of SYK";Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR";Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin";Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin";Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin";Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin";Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK";Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK";Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN";Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase";Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta";Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn";Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase";Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma";Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F";Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397";Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC";Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex";Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN";Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2";Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn";Reactome:R-HSA-377640 "Autophosphorylation of SRC";Reactome:R-HSA-380780 "Activation of Src";Reactome:R-HSA-388831 "Phosphorylation of CD28";Reactome:R-HSA-388833 "Phosphorylation of CTLA-4";Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors";Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors";Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues";Reactome:R-HSA-389354 "Activation of Vav1";Reactome:R-HSA-389762 "Phosphorylation of PD-1";Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha";Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts";Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase";Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn";Reactome:R-HSA-3928578 "EPH receptors autophosphorylate";Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs";Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B";Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1";Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3";Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397";Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1";Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF";Reactome:R-HSA-399934 "Phosphorylation of Plexin-A";Reactome:R-HSA-399946 "Recruitment and activation of Cdk5";Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes";Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2";Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)";Reactome:R-HSA-418859 "Phosphorylation of Unc5C";Reactome:R-HSA-418872 "Phosphorylation of FADK1";Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met";Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase";Reactome:R-HSA-429441 "SYK activation by SRC";Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation";Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8";Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT";Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates";Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1";Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB";Reactome:R-HSA-4420206 "Phosphorylation of SRC-1";Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2";Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1";Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC";Reactome:R-HSA-445085 "Phosphorylation of VAV2";Reactome:R-HSA-445091 "Phosphorylation of Neurofascin";Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1";Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated";Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated";Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB";Reactome:R-HSA-508282 "SYK is a substrate for JAK1";Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2";Reactome:R-HSA-5218642 "PTK2 autophosphorylates";Reactome:R-HSA-5218806 "FYN autophosphorylates";Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118";Reactome:R-HSA-5218812 "FYN phosphorylates PAK2";Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV";Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1";Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta";Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407";Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821";Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG";Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan";Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG";Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2";Reactome:R-HSA-5621370 "SYK autophosphorylates";Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341";Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant";Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII";Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1";Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1";Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1";Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1";Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2";Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1";Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2";Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2";Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1";Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c";Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2";Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3";Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1";Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11";Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3";Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11";Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3";Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11";Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1";Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3";Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11";Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1";Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2";Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2";Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2";Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2";Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1";Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1";Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142";Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52";Reactome:R-HSA-5690702 "LYN phosphorylates CD22";Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2";Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2";Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation";Reactome:R-HSA-6806974 "MET dimers autophosphorylate";Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK";Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1";Reactome:R-HSA-873918 "Transphosphorylation of JAK1";Reactome:R-HSA-873919 "Phosphorylation of JAK2";Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases";Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases";Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor";Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2";Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated";Reactome:R-HSA-8847977 "FRK phosphorylates PTEN";Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation";Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2";Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3";Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B";Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN";Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1";Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1";Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1";Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL";Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1";Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1";Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2";Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3";Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35";Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6";Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ";Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2";Reactome:R-HSA-8851933 "MET phosphorylates GAB1";Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions";Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate";Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate";Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1";Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB";Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation";Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6";Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307";Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15";Reactome:R-HSA-8874078 "PTK2 autophosphorylates";Reactome:R-HSA-8874080 "SRC phosphorylates PTK2";Reactome:R-HSA-8874082 "MET phosphorylates PTK2";Reactome:R-HSA-8875451 "MET phosphorylates CBL";Reactome:R-HSA-8875817 "MET phosphorylates STAT3";Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates";Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL";Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1";Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1";Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3";Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1";Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes";Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18";Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1";Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4";Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR";Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin";Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1";Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2";Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3";Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates";Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1";Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1";Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1";Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2";Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1";Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2";Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2";Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1";Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1";Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3";Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates";Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B";Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5";Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation";Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate";Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1";Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1";Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2";Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer";Reactome:R-HSA-909726 "Phosphorylation of STAT1";Reactome:R-HSA-909729 "Activation of JAK kinases";Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2";Reactome:R-HSA-909732 "Phosphorylation of STAT2";Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated";Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation";Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates";Reactome:R-HSA-9606159 "BTK autophosphorylates";Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2";Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK";Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs";Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates";Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates";Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1";Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR";Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1";Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK";Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers";Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect";Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate";Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1";Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate";Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1";Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate";Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3";Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants";Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants";Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants";Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants";Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers";Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins";Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB";Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1";Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2";Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants";Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants";Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2";Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5";Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B";Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2";Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1";Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1";Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1";Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions";Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK";Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1";Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC";Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3";Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate";Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2";Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10";Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL";Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3";Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1";Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3";Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1";Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS";Reactome:R-HSA-9726848 "SRC phosphorylates RHOU";Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1";Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561";Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL";Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483";Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR";Reactome:R-HSA-9831136 "SH pentamer is phosphorylated";Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)";Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR";Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)";RHEA:10596 WAS Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1";Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma";Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation";Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers";Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers";Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer";Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers";Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers";Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers";Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2";Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5";Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227";Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4";Reactome:R-HSA-1433418 "Phosphorylation of JAK2";Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs";Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs";Reactome:R-HSA-1433506 "Phosphorylation of APS";Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1";Reactome:R-HSA-1470009 "Phosphorylation of STATs";Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases";Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR";Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated";Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes";Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes";Reactome:R-HSA-170991 "SRC-1 autophosphorylates";Reactome:R-HSA-171011 "Binding and activation of MAP Kinase";Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15";Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase";Reactome:R-HSA-177934 "EGFR autophosphorylation";Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase";Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)";Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)";Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers";Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1";Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1";Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2";Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions";Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors";Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3";Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4";Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b";Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c";Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b";Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c";Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b";Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c";Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c";Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src";Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers";Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers";Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2";Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1";Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant";Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants";Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant";Reactome:R-HSA-201521 "ALK autophosphorylation downstream of PTN and MDK";Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes";Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck";Reactome:R-HSA-202174 "Activation of ZAP-70";Reactome:R-HSA-202216 "Phosphorylation of SLP-76";Reactome:R-HSA-202233 "Inactivation of Lck by Csk";Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT";Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1";Reactome:R-HSA-202291 "Activation of Lck";Reactome:R-HSA-202307 "Change of PKC theta conformation";Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers";Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity";Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG";Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases";Reactome:R-HSA-2029453 "Phosphorylation of VAV";Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts";Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants";Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants";Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity";Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding";Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding";Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity";Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants";Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity";Reactome:R-HSA-205289 "Autophosphorylation of KIT";Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src";Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2";Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation";Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs";Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP";Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK";Reactome:R-HSA-2395412 "Phosphorylation of SYK";Reactome:R-HSA-2395439 "Phosphorylation of DAP12";Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1";Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates";Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK";Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK";Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK";Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4";Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN";Reactome:R-HSA-2454239 "Phosphorylation of SYK";Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR";Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin";Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin";Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin";Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin";Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK";Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK";Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN";Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase";Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta";Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn";Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase";Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma";Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F";Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397";Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC";Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex";Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN";Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2";Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn";Reactome:R-HSA-377640 "Autophosphorylation of SRC";Reactome:R-HSA-380780 "Activation of Src";Reactome:R-HSA-388831 "Phosphorylation of CD28";Reactome:R-HSA-388833 "Phosphorylation of CTLA-4";Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors";Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors";Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues";Reactome:R-HSA-389354 "Activation of Vav1";Reactome:R-HSA-389762 "Phosphorylation of PD-1";Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha";Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts";Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase";Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn";Reactome:R-HSA-3928578 "EPH receptors autophosphorylate";Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs";Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B";Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1";Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3";Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397";Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1";Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF";Reactome:R-HSA-399934 "Phosphorylation of Plexin-A";Reactome:R-HSA-399946 "Recruitment and activation of Cdk5";Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes";Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2";Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)";Reactome:R-HSA-418859 "Phosphorylation of Unc5C";Reactome:R-HSA-418872 "Phosphorylation of FADK1";Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met";Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase";Reactome:R-HSA-429441 "SYK activation by SRC";Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation";Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8";Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT";Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates";Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1";Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB";Reactome:R-HSA-4420206 "Phosphorylation of SRC-1";Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2";Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1";Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC";Reactome:R-HSA-445085 "Phosphorylation of VAV2";Reactome:R-HSA-445091 "Phosphorylation of Neurofascin";Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1";Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated";Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated";Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB";Reactome:R-HSA-508282 "SYK is a substrate for JAK1";Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2";Reactome:R-HSA-5218642 "PTK2 autophosphorylates";Reactome:R-HSA-5218806 "FYN autophosphorylates";Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118";Reactome:R-HSA-5218812 "FYN phosphorylates PAK2";Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV";Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1";Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta";Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407";Reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814";Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG";Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan";Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG";Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2";Reactome:R-HSA-5621370 "SYK autophosphorylates";Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341";Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant";Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII";Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1";Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1";Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1";Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1";Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2";Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1";Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2";Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2";Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1";Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c";Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2";Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3";Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1";Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11";Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3";Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11";Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3";Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11";Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1";Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3";Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11";Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1";Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2";Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2";Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2";Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2";Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1";Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1";Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142";Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52";Reactome:R-HSA-5690702 "LYN phosphorylates CD22";Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2";Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2";Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation";Reactome:R-HSA-6806974 "MET dimers autophosphorylate";Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK";Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1";Reactome:R-HSA-873918 "Transphosphorylation of JAK1";Reactome:R-HSA-873919 "Phosphorylation of JAK2";Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases";Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases";Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor";Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2";Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated";Reactome:R-HSA-8847977 "FRK phosphorylates PTEN";Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation";Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2";Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3";Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B";Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN";Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1";Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1";Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1";Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL";Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1";Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1";Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2";Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3";Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35";Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6";Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ";Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2";Reactome:R-HSA-8851933 "MET phosphorylates GAB1";Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions";Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate";Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate";Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1";Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB";Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation";Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6";Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307";Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15";Reactome:R-HSA-8874078 "PTK2 autophosphorylates";Reactome:R-HSA-8874080 "SRC phosphorylates PTK2";Reactome:R-HSA-8874082 "MET phosphorylates PTK2";Reactome:R-HSA-8875451 "MET phosphorylates CBL";Reactome:R-HSA-8875817 "MET phosphorylates STAT3";Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates";Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL";Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1";Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1";Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3";Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1";Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes";Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18";Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1";Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC";Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC";Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4";Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR";Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin";Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1";Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2";Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3";Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates";Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1";Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1";Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1";Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2";Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1";Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2";Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2";Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1";Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1";Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3";Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates";Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B";Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5";Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation";Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate";Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1";Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1";Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2";Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer";Reactome:R-HSA-909726 "Phosphorylation of STAT1";Reactome:R-HSA-909729 "Activation of JAK kinases";Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2";Reactome:R-HSA-909732 "Phosphorylation of STAT2";Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated";Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation";Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates";Reactome:R-HSA-9606159 "BTK autophosphorylates";Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2";Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK";Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs";Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates";Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates";Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1";Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR";Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1";Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK";Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers";Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect";Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate";Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1";Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate";Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1";Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate";Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3";Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants";Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants";Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants";Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants";Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers";Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins";Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB";Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1";Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2";Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants";Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants";Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2";Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5";Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B";Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2";Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1";Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1";Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1";Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions";Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK";Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1";Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC";Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3";Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate";Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2";Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10";Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL";Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3";Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1";Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3";Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1";Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS";Reactome:R-HSA-9726848 "SRC phosphorylates RHOU";Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561";Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL";Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 486";Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR";Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)";Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR";Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)";RHEA:10596 molecular_function GO:0004714 transmembrane receptor protein tyrosine kinase activity xrefs EC:2.7.10.1;MetaCyc:2.7.10.1-RXN;Reactome:R-HSA-166544 "TrkA receptor autophosphorylates";Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated";Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1";Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor";Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase";Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR";Reactome:R-HSA-198295 "TRKA phosphorylates IRS";Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA";Reactome:R-HSA-74711 "Phosphorylation of IRS";Reactome:R-HSA-74742 "Phosphorylation of SHC1";Reactome:R-HSA-8852552 "MST1R autophosphorylates";Reactome:R-HSA-8853792 "RET tyrosine phosphorylation";Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor";Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation";Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction";Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated";Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated";Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated";Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4";Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction";Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated";Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated";Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated";Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3";Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1";Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1";Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5";Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2";Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5";Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2";Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA";Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1";Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1";Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2";Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1";Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated";Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3";Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3";Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2";Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" WAS EC:2.7.10.1;MetaCyc:2.7.10.1-RXN;Reactome:R-HSA-166544 "TrkA receptor autophosphorylates";Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated";Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1";Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor";Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR";Reactome:R-HSA-198295 "TRKA phosphorylates IRS";Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA";Reactome:R-HSA-74711 "Phosphorylation of IRS";Reactome:R-HSA-74742 "Phosphorylation of SHC1";Reactome:R-HSA-8852552 "MST1R autophosphorylates";Reactome:R-HSA-8853792 "RET tyrosine phosphorylation";Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor";Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation";Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction";Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated";Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated";Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated";Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4";Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction";Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated";Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated";Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated";Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3";Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1";Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1";Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5";Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2";Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5";Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2";Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA";Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1";Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1";Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2";Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1";Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated";Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3";Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3";Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3";Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2";Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" molecular_function GO:0004722 protein serine/threonine phosphatase activity xrefs EC:3.1.3.16;MetaCyc:3.1.3.16-RXN;Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A";Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex";Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";Reactome:R-HSA-380949 "AMPK is dephosphorylated";Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2";Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH";Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1";Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs";Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex";Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs";Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2";Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1" WAS EC:3.1.3.16;MetaCyc:3.1.3.16-RXN;Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";Reactome:R-HSA-380949 "AMPK is dephosphorylated";Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";Reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate";Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH";Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1";Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs";Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex";Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs";Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2" molecular_function GO:0004725 protein tyrosine phosphatase activity xrefs EC:3.1.3.48;MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN;Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2";Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR";Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2";Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2";Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45";Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)";Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1";Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases";Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn";Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)";Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX";Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET";Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET";Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation";Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1";Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs";Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6";Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22";Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70";Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248";Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1172 (Y1148)";Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021";Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248";Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15";Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12";Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1";Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB";Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3";Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A";Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B";Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS";Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3";Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers";Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3";Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2";Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B";Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1";Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP";RHEA:10684 WAS EC:3.1.3.48;MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN;Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2";Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR";Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2";Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2";Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45";Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)";Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1";Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases";Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn";Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)";Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX";Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET";Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET";Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation";Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1";Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs";Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6";Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22";Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70";Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248";Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)";Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021";Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248";Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15";Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12";Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1";Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB";Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3";Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A";Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B";Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS";Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3";Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers";Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3";Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2";Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B";Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1";Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP";RHEA:10684 molecular_function GO:0004738 pyruvate dehydrogenase activity xrefs Reactome:R-HSA-71397 "lipo-PDH decarboxylates PYR to Ac-CoA" WAS MetaCyc:RXN0-1134;Reactome:R-HSA-71397 "lipo-PDH decarboxylates PYR to Ac-CoA" molecular_function GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity xrefs EC:1.2.4.1;MetaCyc:RXN0-1134;RHEA:19189 WAS EC:1.2.4.1;RHEA:19189 molecular_function GO:0004743 pyruvate kinase activity xrefs EC:2.7.1.40;MetaCyc:PEPDEPHOS-RXN;Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP";RHEA:18159 WAS EC:2.7.1.40;MetaCyc:PEPDEPHOS-RXN;Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens";RHEA:18159 molecular_function GO:0004758 serine C-palmitoyltransferase activity xrefs EC:2.3.1.50;KEGG_REACTION:R01281;MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN;Reactome:R-HSA-428127 "SPTLC complexes transfer acyl-CoA onto serine";RHEA:14761 WAS EC:2.3.1.50;KEGG_REACTION:R01281;MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN;Reactome:R-HSA-428127 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2";RHEA:14761 molecular_function GO:0004767 sphingomyelin phosphodiesterase activity xrefs EC:3.1.4.12;KEGG_REACTION:R02541;MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN;Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM";Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)";Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)";Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin";Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets";RHEA:19253 WAS EC:3.1.4.12;KEGG_REACTION:R02541;MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN;Reactome:R-HSA-1605797 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)";Reactome:R-HSA-1606273 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)";Reactome:R-HSA-1606288 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)";Reactome:R-HSA-1640164 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin";Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets";RHEA:19253 molecular_function GO:0004773 steryl-sulfatase activity xrefs EC:3.1.6.2;MetaCyc:STERYL-SULFATASE-RXN;Reactome:R-HSA-1606839 "ARSC hydrolyzes steroid sulfates";RHEA:19873 WAS EC:3.1.6.2;MetaCyc:STERYL-SULFATASE-RXN;Reactome:R-HSA-1606839 "Steryl sulfatase hydrolyses sulfate from steroid sulfates";RHEA:19873 molecular_function GO:0004842 ubiquitin-protein transferase activity xrefs KEGG_REACTION:R03876;Reactome:R-HSA-1169394 "ISGylation of IRF3";Reactome:R-HSA-1169395 "ISGylation of viral protein NS1";Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase";Reactome:R-HSA-1169398 "ISGylation of host protein filamin B";Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes";Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)";Reactome:R-HSA-1169406 "ISGylation of host proteins";Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha";Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha";Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH";Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41";Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3";Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3";Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)";Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2";Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling";Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1";Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex";Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP";Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex";Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-179417 "Multiubiquitination of Nek2A";Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G";Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex";Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85";Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)";Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty";Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix";Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty";Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7";Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21";Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX";Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand";Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2";Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2";Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer";Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1";Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination";Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling";Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6";Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF";Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex";Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34";Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7";Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2";Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3";Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2";Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7";Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3";Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3";Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )";Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels";Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants";Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants";Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants";Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA";Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56";Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21";Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1";Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2";Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1";Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2";Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)";Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins";Reactome:R-HSA-4332236 "CBL neddylates TGFBR2";Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated";Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation";Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1";Reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates";Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1";Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments";Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated";Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP";Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex";Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates";Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1";Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1";Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2";Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3";Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA";Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH";Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA";Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP";Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP";Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3";Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK";Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated";Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2";Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2";Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains";Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1";Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A";Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO";Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1";Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4";Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3";Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha";Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3";Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex";Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated";Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS";Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2";Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains";Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation";Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation";Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer";Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363";Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates";Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5";Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex";Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane";Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6";Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50";Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3";Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627";Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634";Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627";Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR";Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530";Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex";Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2";Reactome:R-HSA-983153 "E1 mediated ubiquitin activation";Reactome:R-HSA-983156 "Polyubiquitination of substrate";Reactome:R-HSA-9833155 "Ubiquitination of STAT2";Reactome:R-HSA-9833973 "ISGylation of PKR" WAS KEGG_REACTION:R03876;Reactome:R-HSA-1169394 "ISGylation of IRF3";Reactome:R-HSA-1169395 "ISGylation of viral protein NS1";Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase";Reactome:R-HSA-1169398 "ISGylation of host protein filamin B";Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes";Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)";Reactome:R-HSA-1169406 "ISGylation of host proteins";Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha";Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha";Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH";Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41";Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3";Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3";Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)";Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2";Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling";Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1";Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex";Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP";Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex";Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-179417 "Multiubiquitination of Nek2A";Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G";Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex";Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85";Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)";Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)";Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty";Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix";Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty";Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7";Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21";Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX";Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand";Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2";Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2";Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer";Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1";Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination";Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling";Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6";Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF";Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex";Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34";Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7";Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2";Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3";Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2";Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7";Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3";Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3";Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )";Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels";Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants";Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants";Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants";Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA";Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56";Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21";Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1";Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2";Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1";Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2";Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)";Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins";Reactome:R-HSA-4332236 "CBL neddylates TGFBR2";Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated";Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation";Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1";Reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates";Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1";Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments";Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated";Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP";Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex";Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates";Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1";Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1";Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2";Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3";Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA";Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH";Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA";Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP";Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP";Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3";Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK";Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated";Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2";Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2";Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains";Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1";Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A";Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO";Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1";Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4";Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3";Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha";Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3";Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex";Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated";Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS";Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2";Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains";Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation";Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation";Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer";Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363";Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates";Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5";Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex";Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane";Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6";Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50";Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3";Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627";Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634";Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627";Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR";Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530";Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex";Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2";Reactome:R-HSA-983153 "E1 mediated ubiquitin activation";Reactome:R-HSA-983156 "Polyubiquitination of substrate" molecular_function GO:0004844 uracil DNA N-glycosylase activity xrefs EC:3.2.2.27;https://github.com/geneontology/go-ontology/issues/25051;Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase";Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase";Reactome:R-HSA-9817512 "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3" WAS EC:3.2.2.27;https://github.com/geneontology/go-ontology/issues/25051;Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase";Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase" molecular_function GO:0004848 ureidoglycolate hydrolase activity xrefs EC:3.5.1.116;KEGG_REACTION:R00469;MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN;RHEA:19809 WAS EC:3.5.3.19;KEGG_REACTION:R00469;MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN;RHEA:19809 molecular_function GO:0005049 nuclear export signal receptor activity xrefs Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" WAS N/A molecular_function GO:0005215 transporter activity xrefs N/A WAS Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion";Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" molecular_function GO:0005261 monoatomic cation channel activity xrefs Reactome:R-HSA-1168376 "STIM1 oligomerizes";Reactome:R-HSA-1296043 "Activation of HCN channels";Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol";Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol";Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7";Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT";Reactome:R-HSA-9706720 "SARS-CoV-1 E transports Ca2+";Reactome:R-HSA-9712190 "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol";Reactome:R-HSA-9754616 "SARS-CoV-2 E pentamer transports Ca2+";Reactome:R-HSA-9837835 "SH pentamer transports K+" WAS Reactome:R-HSA-1168376 "STIM1 oligomerizes";Reactome:R-HSA-1296043 "Activation of HCN channels";Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol";Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol";Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7";Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT";Reactome:R-HSA-9706720 "SARS-CoV-1 E transports Ca2+";Reactome:R-HSA-9712190 "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol";Reactome:R-HSA-9754616 "SARS-CoV-2 E pentamer transports Ca2+" molecular_function GO:0008117 sphinganine-1-phosphate aldolase activity xrefs EC:4.1.2.27;MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN;Reactome:R-HSA-428681 "PXLP-SGPL1 cleaves sphingoid-1-phosphates";RHEA:18593 WAS EC:4.1.2.27;MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN;Reactome:R-HSA-428676 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal";Reactome:R-HSA-428681 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal";RHEA:18593 molecular_function GO:0008120 ceramide glucosyltransferase activity xrefs EC:2.4.1.80;MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN;Reactome:R-HSA-1638104 "UGCG transfers glucose to ceramide";RHEA:12088 WAS EC:2.4.1.80;MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN;Reactome:R-HSA-1638104 "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide";RHEA:12088 molecular_function GO:0008131 primary amine oxidase activity xrefs EC:1.4.3.21;KEGG_REACTION:R01853;MetaCyc:RXN-9597;Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT";Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA";Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR";Reactome:R-HSA-374909 "Catabolism of Noradrenaline";Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC";Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA";Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT";Reactome:R-HSA-5696146 "AOC2 deaminates TYR";Reactome:R-HSA-5696183 "AOC3 deaminates BZAM" WAS EC:1.4.3.21;KEGG_REACTION:R01853;MetaCyc:RXN-9597;Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT";Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA";Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR";Reactome:R-HSA-374909 "Metabolism of Noradrenaline";Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC";Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA";Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT";Reactome:R-HSA-5696146 "AOC2 deaminates TYR";Reactome:R-HSA-5696183 "AOC3 deaminates BZAM" molecular_function GO:0008177 succinate dehydrogenase (quinone) activity xrefs EC:1.3.5.1;KEGG_REACTION:R02164;MetaCyc:RXN-14971;Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex";Reactome:R-HSA-70994 "Succinate <=> Fumarate (with FAD redox reaction on enzyme)";RHEA:40523 WAS EC:1.3.5.1;KEGG_REACTION:R02164;MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN;Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex";Reactome:R-HSA-70994 "Succinate <=> Fumarate (with FAD redox reaction on enzyme)";RHEA:13713 molecular_function GO:0008195 phosphatidate phosphatase activity xrefs EC:3.1.3.4;MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN;Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN";Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A";Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 556) by PP2A";Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1";Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A";Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol";Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA";Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate";RHEA:27429 WAS EC:3.1.3.4;MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN;Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN";Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A";Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A";Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex";Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 568) by PP2A";Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1";Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A";Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol";Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA";Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate";RHEA:27429 molecular_function GO:0008236 serine-type peptidase activity xrefs Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin";Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)";Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:RCbl";Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)";Reactome:R-HSA-9839072 "HTRA2 degrades APP (Amyloid-beta precursor protein)";Reactome:R-HSA-9839110 "HTRA2 degrades NDUFA13 (GRIM-19)" WAS Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin";Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)";Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:RCbl";Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)" molecular_function GO:0008237 metallopeptidase activity xrefs Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2";Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1";Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain";Reactome:R-HSA-2022368 "MME:Zn2+ hydrolyses AGT(34-42)";Reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)";Reactome:R-HSA-2022396 "MME:Zn2+ hydrolyses AGT(34-43)";Reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)";Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants";Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding";Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1";Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding";Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs";Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)";Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)";Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)";Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)";Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)";Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)";Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)";Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3";Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4";Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163";Reactome:R-HSA-9759522 "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform" WAS Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2";Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1";Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain";Reactome:R-HSA-2022368 "MME:Zn2+ hydrolyses AGT(34-42)";Reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)";Reactome:R-HSA-2022396 "MME:Zn2+ hydrolyses AGT(34-43)";Reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)";Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants";Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding";Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1";Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding";Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs";Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)";Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)";Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)";Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)";Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)";Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)";Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)";Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3";Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4";Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163" molecular_function GO:0008417 fucosyltransferase activity xrefs Reactome:R-HSA-9033949 "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC";Reactome:R-HSA-9846332 "FUT1,2 transfer fucose to gangliosides" WAS Reactome:R-HSA-9033949 "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC" molecular_function GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity xrefs EC:2.1.1.201;Reactome:R-HSA-2162188 "MDMQ10H2 is methylated to DMQ10H2 by COQ5";RHEA:28286 WAS N/A molecular_function GO:0008469 histone arginine N-methyltransferase activity xrefs N/A WAS Reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)";Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)";Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)";Reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3";Reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter";Reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter";Reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter";Reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter" molecular_function GO:0008481 sphinganine kinase activity xrefs EC:2.7.1.91;MetaCyc:SPHINGANINE-KINASE-RXN;RHEA:15465 WAS EC:2.7.1.91;MetaCyc:SPHINGANINE-KINASE-RXN;Reactome:R-HSA-428214 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP";RHEA:15465 molecular_function GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity xrefs Reactome:R-HSA-9851347 "B4GALT5/6 transfer Gal to GlcCer" WAS N/A molecular_function GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity xrefs Reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein";Reactome:R-HSA-9603989 "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain";Reactome:R-HSA-9845516 "B3GALT4 transfers Gal to gangliosides" WAS Reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein";Reactome:R-HSA-9603989 "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain" molecular_function GO:0008659 (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity xrefs RHEA:41892 WAS EC:4.2.1.59;RHEA:41892 molecular_function GO:0008693 (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity xrefs MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN;RHEA:41860 WAS RHEA:41860 molecular_function GO:0008942 nitrite reductase [NAD(P)H] activity xrefs EC:1.7.1.4;KEGG_REACTION:R00787;KEGG_REACTION:R00789;MetaCyc:RXN0-6377;RHEA:24632 WAS EC:1.7.1.4;KEGG_REACTION:R00787;KEGG_REACTION:R00789;MetaCyc:RXN0-6377 molecular_function GO:0009982 pseudouridine synthase activity xrefs Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs";Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs";Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)";Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA";Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA";RHEA:48348 WAS Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs";Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs";Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)";Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA";Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA" molecular_function GO:0010420 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity xrefs EC:2.1.1.114;MetaCyc:RXN-9281;Reactome:R-HSA-2162193 "DHDB is methylated to MHDB by COQ3";RHEA:44452 WAS EC:2.1.1.114;MetaCyc:RXN-9281;RHEA:44452 molecular_function GO:0010857 calcium-dependent protein kinase activity xrefs N/A WAS Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308";Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308" molecular_function GO:0010945 coenzyme A diphosphatase activity xrefs MetaCyc:RXN-10811;Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT";Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT";Reactome:R-HSA-9837354 "NUDT8 hydrolyzes CoA-SH to PPANT";RHEA:50044 WAS MetaCyc:RXN-10811;Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT";Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT";RHEA:50044 molecular_function GO:0015078 proton transmembrane transporter activity xrefs Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase";Reactome:R-HSA-164834 "Enzyme-bound ATP is released";Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion";Reactome:R-HSA-170026 "Protons are translocated from the intermembrane space to the matrix";Reactome:R-HSA-74723 "Endosome acidification";Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" WAS Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase";Reactome:R-HSA-164834 "Enzyme-bound ATP is released";Reactome:R-HSA-170026 "Protons are translocated from the intermembrane space to the matrix";Reactome:R-HSA-74723 "Endosome acidification";Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" molecular_function GO:0015228 coenzyme A transmembrane transporter activity xrefs Reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix";Reactome:R-HSA-9837333 "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP" WAS N/A molecular_function GO:0015291 secondary active transmembrane transporter activity xrefs TC:2.A WAS Reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix";TC:2.A molecular_function GO:0016289 acyl-CoA hydrolase activity xrefs EC:3.1.2.10;KEGG_REACTION:R00521;MetaCyc:FORMYL-COA-HYDROLASE-RXN;Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH";RHEA:19741 WAS Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH" molecular_function GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity xrefs EC:1.1.1.211;MetaCyc:1.1.1.211-RXN;RHEA:52656 WAS EC:1.1.1.211;MetaCyc:1.1.1.211-RXN;Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA";RHEA:52656 molecular_function GO:0016791 phosphatase activity xrefs EC:3.1.3.-;Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL";Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P";Reactome:R-HSA-9837419 "PANK4 hydrolyzes PPANT to pantetheine" WAS EC:3.1.3.-;Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL";Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P" molecular_function GO:0017040 N-acylsphingosine amidohydrolase activity xrefs EC:3.5.1.23;MetaCyc:CERAMIDASE-RXN;Reactome:R-HSA-1606583 "ASAH2 hydrolyzes ceramide (plasma membrane)";Reactome:R-HSA-1606602 "ASAH1 hydrolyzes ceramide";Reactome:R-HSA-428205 "ACER2 hydrolyzes ceramide (Golgi)";Reactome:R-HSA-428231 "ACER1 hydrolyzes ceramide (endoplasmic reticulum)";RHEA:20856 WAS EC:3.5.1.23;MetaCyc:CERAMIDASE-RXN;Reactome:R-HSA-1606583 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)";Reactome:R-HSA-1606602 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)";Reactome:R-HSA-428205 "ceramide + H2O => stearate + sphingosine [Golgi]";Reactome:R-HSA-428231 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]";RHEA:20856 molecular_function GO:0017050 D-erythro-sphingosine kinase activity xrefs EC:2.7.1.91;MetaCyc:RXN3DJ-11417;Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate";Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation";RHEA:35847 WAS EC:2.7.1.91;MetaCyc:RXN3DJ-11417;Reactome:R-HSA-428273 "SPHK1 phosphorylates SPG to S1P";Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate";Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation";Reactome:R-HSA-9695949 "SPHK2 phosphorylates SPG to S1P";RHEA:35847 molecular_function GO:0017089 glycolipid transfer activity xrefs Reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane";Reactome:R-HSA-9697077 "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall";Reactome:R-HSA-9844955 "CLN3 transports GalCer to plasma membrane";Reactome:R-HSA-9845055 "PLEKHA8 catalyzes transport of GlcCer to plasma membrane" WAS Reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane";Reactome:R-HSA-9697077 "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall" molecular_function GO:0018638 toluene 4-monooxygenase activity xrefs EC:1.14.13.236;RHEA:41380;UM-BBD_enzymeID:e0225 WAS EC:1.14.13.-;UM-BBD_enzymeID:e0225 molecular_function GO:0018641 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity xrefs UM-BBD_reactionID:r0048 WAS EC:1.14.13.-;UM-BBD_reactionID:r0048 molecular_function GO:0018814 phenylacetaldoxime dehydratase activity xrefs EC:4.8.1.4;KEGG_REACTION:R07638;MetaCyc:4.99.1.7-RXN;RHEA:20069;UM-BBD_reactionID:r0697 WAS EC:4.99.1.7;KEGG_REACTION:R07638;MetaCyc:4.99.1.7-RXN;RHEA:20069;UM-BBD_reactionID:r0697 molecular_function GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity xrefs EC:4.2.1.59;MetaCyc:4.2.1.59-RXN;RHEA:13097 WAS EC:4.2.1.59;MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN;RHEA:13097 molecular_function GO:0019706 protein-cysteine S-palmitoyltransferase activity xrefs EC:2.3.1.225;Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer";Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1";Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated";Reactome:R-HSA-9694341 "Spike protein gets palmitoylated";Reactome:R-HSA-9829047 "F0 is palmitoylated";Reactome:R-HSA-9830875 "G is palmitoylated";RHEA:36683 WAS EC:2.3.1.225;Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer";Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1";Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated";Reactome:R-HSA-9694341 "Spike protein gets palmitoylated";RHEA:36683 molecular_function GO:0022857 transmembrane transporter activity xrefs Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61";Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate";Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics";Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate";Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA";Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome";Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" WAS Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61";Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate";Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate";Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA";Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome";Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" molecular_function GO:0030290 sphingolipid activator protein activity xrefs Reactome:R-HSA-1605717 "GM2A binds and mobilizes ligands";Reactome:R-HSA-9840470 "PSAP(195-273) dimer:PE binds and mobilizes ligands" WAS Reactome:R-HSA-1605717 "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage" molecular_function GO:0030596 alpha-L-rhamnosidase activity xrefs EC:3.2.1.40;KEGG_REACTION:R02436;MetaCyc:3.2.1.40-RXN;RHEA:17465 WAS EC:3.2.1.40;MetaCyc:3.2.1.40-RXN molecular_function GO:0031071 cysteine desulfurase activity xrefs EC:2.8.1.7;Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster";Reactome:R-HSA-947514 "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3";RHEA:43892 WAS EC:2.8.1.7;Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster";Reactome:R-HSA-947514 "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3";RHEA:43892 molecular_function GO:0031544 peptidyl-proline 3-dioxygenase activity xrefs Reactome:R-HSA-9630769 "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23" WAS N/A molecular_function GO:0031955 short-chain fatty acid-CoA ligase activity xrefs RHEA:52860 WAS N/A molecular_function GO:0031957 very long-chain fatty acid-CoA ligase activity xrefs Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA";Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA";Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA";RHEA:54536 WAS Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA";Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA";Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA" molecular_function GO:0032453 histone H3K4 demethylase activity xrefs Reactome:R-HSA-9822461 "KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3)";Reactome:R-HSA-9822467 "KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3)" WAS N/A molecular_function GO:0033188 sphingomyelin synthase activity xrefs EC:2.7.8.27;KEGG_REACTION:R08969;MetaCyc:2.7.8.27-RXN;Reactome:R-HSA-429786 "SGMS2 transfers phosphocholine onto ceramide";Reactome:R-HSA-429798 "SGMS1 transfers phosphocholine onto ceramide";RHEA:18765 WAS EC:2.7.8.27;KEGG_REACTION:R08969;MetaCyc:2.7.8.27-RXN;Reactome:R-HSA-429786 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]";Reactome:R-HSA-429798 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]";RHEA:18765 molecular_function GO:0034013 aliphatic aldoxime dehydratase activity xrefs EC:4.8.1.2;MetaCyc:4.99.1.5-RXN;RHEA:11316 WAS EC:4.99.1.5;MetaCyc:4.99.1.5-RXN;RHEA:11316 molecular_function GO:0034458 3'-5' RNA helicase activity xrefs Reactome:R-HSA-9836927 "SUPV3L1 unwinds double-stranded mitochondiral RNA" WAS N/A molecular_function GO:0034604 pyruvate dehydrogenase (NAD+) activity xrefs EC:1.2.1.104;KEGG_REACTION:R00209;MetaCyc:PYRUVDEH-RXN;RHEA:28042 WAS KEGG_REACTION:R00209;MetaCyc:PYRUVDEH-RXN;RHEA:28042 molecular_function GO:0035516 broad specificity oxidative DNA demethylase activity xrefs EC:1.14.11.33;MetaCyc:RXN-12353;Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2";Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3";RHEA:30299 WAS EC:1.14.11.33;MetaCyc:RXN-12353;RHEA:30299 molecular_function GO:0036139 peptidyl-histidine dioxygenase activity xrefs Reactome:R-HSA-9630967 "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A";Reactome:R-HSA-9630993 "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8" WAS N/A molecular_function GO:0042054 histone methyltransferase activity xrefs Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)";Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)";Reactome:R-HSA-9822583 "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)" WAS N/A molecular_function GO:0042284 sphingolipid delta-4 desaturase activity xrefs EC:1.14.19.17;Reactome:R-HSA-428259 "DEGS1 dehydrogenates dihydroceramide";RHEA:46544 WAS EC:1.14.19.17;Reactome:R-HSA-428259 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O";RHEA:46544 molecular_function GO:0042392 sphingosine-1-phosphate phosphatase activity xrefs MetaCyc:RXN3DJ-25;Reactome:R-HSA-428690 "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate";Reactome:R-HSA-428696 "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate";RHEA:27518 WAS MetaCyc:RXN3DJ-25;Reactome:R-HSA-428690 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]";Reactome:R-HSA-428696 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]";Reactome:R-HSA-428701 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]";RHEA:27518 molecular_function GO:0042910 xenobiotic transmembrane transporter activity xrefs Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+";Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" WAS N/A molecular_function GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity xrefs EC:3.1.11.4 WAS N/A molecular_function GO:0046624 sphingolipid transporter activity xrefs Reactome:R-HSA-9695890 "SPNS2,MFSD2B transport S1P from cytosol to extracellular region";Reactome:R-HSA-9843721 "ABCC1,ABCG2 transport C18-S1P to extracellular region" WAS Reactome:R-HSA-9695890 "SPNS2 transports S1P from cytosol to extracellular region" molecular_function GO:0047101 branched-chain alpha-keto acid dehydrogenase activity xrefs EC:1.2.1.25;MetaCyc:1.2.1.25-RXN WAS EC:1.2.1.25;MetaCyc:1.2.1.25-RXN;RHEA:13997 molecular_function GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity xrefs EC:2.4.1.206;MetaCyc:2.4.1.206-RXN;Reactome:R-HSA-9846501 "B3GNT5 transfers GlcNAc to LacCer";RHEA:13905 WAS EC:2.4.1.206;MetaCyc:2.4.1.206-RXN;RHEA:13905 molecular_function GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity xrefs EC:2.4.1.79;MetaCyc:2.4.1.79-RXN;Reactome:R-HSA-8878914 "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer";RHEA:22252 WAS EC:2.4.1.79;MetaCyc:2.4.1.79-RXN;Reactome:R-HSA-8878914 "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer";RHEA:22252 molecular_function GO:0047450 (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity xrefs KEGG_REACTION:R04428;RHEA:41808 WAS KEGG_REACTION:R04428;MetaCyc:4.2.1.58-RXN;RHEA:41808 molecular_function GO:0047560 3-dehydrosphinganine reductase activity xrefs EC:1.1.1.102;KEGG_REACTION:R02978;MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN;Reactome:R-HSA-428123 "KDSR reduces 3-ketosphingoid";RHEA:22640 WAS EC:1.1.1.102;KEGG_REACTION:R02978;MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN;Reactome:R-HSA-428123 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+";RHEA:22640 molecular_function GO:0047617 fatty acyl-CoA hydrolase activity xrefs EC:3.1.2.20;EC:3.1.2.3;MetaCyc:ACYL-COA-HYDROLASE-RXN;Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA";Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA";Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA";RHEA:16781 WAS EC:3.1.2.20;MetaCyc:ACYL-COA-HYDROLASE-RXN;Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA";Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA";Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA";RHEA:16781 molecular_function GO:0047720 indoleacetaldoxime dehydratase activity xrefs EC:4.8.1.3;KEGG_REACTION:R04093;MetaCyc:RXN-19838;RHEA:23156 WAS EC:4.99.1.6;KEGG_REACTION:R04093;MetaCyc:RXN-19838;RHEA:23156 molecular_function GO:0047826 D-lysine 5,6-aminomutase activity xrefs EC:5.4.3.4;KEGG_REACTION:R02852;MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN;RHEA:18241 WAS EC:5.4.3.4;KEGG_REACTION:R02852;MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN;RHEA:18241 molecular_function GO:0047904 fructose 5-dehydrogenase activity xrefs EC:1.1.5.14;KEGG_REACTION:R00873;MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN;RHEA:22304 WAS EC:1.1.99.11;KEGG_REACTION:R00873;MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN;RHEA:22304 molecular_function GO:0050135 NADP+ nucleosidase activity xrefs Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+";RHEA:19849 WAS EC:3.2.2.6;MetaCyc:NADNUCLEOSID-RXN molecular_function GO:0050265 RNA uridylyltransferase activity xrefs EC:2.7.7.52;MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN;Reactome:R-HSA-8941312 "TUT4,TUT7 oligouridylate mRNA";RHEA:14785 WAS EC:2.7.7.52;MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN;Reactome:R-HSA-8941312 "ZCCHC6, ZCCHC11 are mRNA uridyltransferases";RHEA:14785 molecular_function GO:0050291 sphingosine N-acyltransferase activity xrefs EC:2.3.1.24;MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-428185 "Ceramide synthases transfer acyl-CoA onto sphingoid";RHEA:23768 WAS EC:2.3.1.24;MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-428185 "sphinganine + stearyl-CoA => dihydroceramide + CoASH";RHEA:23768 molecular_function GO:0050501 hyaluronan synthase activity xrefs EC:2.4.1.212;MetaCyc:2.4.1.212-RXN;Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerization of HA";RHEA:12528 WAS EC:2.4.1.212;MetaCyc:2.4.1.212-RXN;Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerisation of HA";RHEA:12528 molecular_function GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity xrefs EC:2.4.1.228;MetaCyc:2.4.1.228-RXN;Reactome:R-HSA-9846477 "A4GALT transfers galactose to LacCer";RHEA:11924 WAS EC:2.4.1.228;MetaCyc:2.4.1.228-RXN;RHEA:11924 molecular_function GO:0051392 tRNA N-acetyltransferase activity xrefs RHEA:53876 WAS N/A molecular_function GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity xrefs EC:3.1.11.3 WAS N/A molecular_function GO:0052642 lysophosphatidic acid phosphatase activity xrefs EC:3.1.3.106;MetaCyc:RXNQT-4375;Reactome:R-HSA-8878654 "ACP6 hydrolyses MYS-LPA";RHEA:33155 WAS Reactome:R-HSA-8878654 "ACP6 hydrolyses MYS-LPA" molecular_function GO:0052742 phosphatidylinositol kinase activity xrefs Reactome:R-HSA-1675773 "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane" WAS N/A molecular_function GO:0052815 medium-chain fatty acyl-CoA hydrolase activity xrefs MetaCyc:3.1.2.19-RXN;RHEA:68184 WAS N/A molecular_function GO:0052816 long-chain fatty acyl-CoA hydrolase activity xrefs RHEA:67680 WAS N/A molecular_function GO:0052817 very long-chain fatty acyl-CoA hydrolase activity xrefs RHEA:67072 WAS N/A molecular_function GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity xrefs EC:2.1.1.221;MetaCyc:RXN-12459;Reactome:R-HSA-6786621 "TRMT10A methylates guanosine-9 in tRNA";Reactome:R-HSA-6787591 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9";RHEA:43156 WAS EC:2.1.1.221;MetaCyc:RXN-12459;RHEA:43156 molecular_function GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity xrefs EC:2.1.1.228;MetaCyc:RXN-12458;Reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)";RHEA:36899 WAS EC:2.1.1.228;MetaCyc:RXN-12458;RHEA:36899 molecular_function GO:0061522 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity xrefs EC:3.1.2.28;RHEA:26309 WAS N/A molecular_function GO:0061542 3-demethylubiquinol-n 3-O-methyltransferase activity xrefs EC:2.1.1.64;Reactome:R-HSA-2162186 "DeMQ10H2 is methylated to Q10H2 by COQ3";RHEA:44380 WAS EC:2.1.1.64;RHEA:44380 molecular_function GO:0061630 ubiquitin protein ligase activity xrefs Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL";Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1";Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)";Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8";Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE";Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN";Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1";Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2";Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1";Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization";Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation";Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated";Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1";Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1";Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3";Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1";Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1";Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2";Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3";Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4";Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1";Reactome:R-HSA-5674022 "BRAP autoubiquitinates";Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX";Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1";Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal";Reactome:R-HSA-5689111 "PARK2 autoubiquitinates";Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1";Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II";Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC";Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI";Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC";Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2";Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY";Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53";Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4";Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53";Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate";Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination";Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN";Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin";Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex";Reactome:R-HSA-8848829 "CBL autoubiquitinates";Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN";Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA";Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7";Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839";Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR";Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del";Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5";Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET";Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination";Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET";Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex";Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC";Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA";Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10";Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2";Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B";Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA";Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA";Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11";Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN";Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN";Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3";Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3";Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11";Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5";Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73";Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2";Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2";Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2";Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2";Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1";Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3";Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11";Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL";Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation";Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216";Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4";Reactome:R-HSA-9685195 "SARS-CoV-1 9b recruits ITCH to MAVS";Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363";Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2";Reactome:R-HSA-9705738 "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7";Reactome:R-HSA-9706354 "Ubiquitination of FLT3";Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3";Reactome:R-HSA-9708517 "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))";Reactome:R-HSA-9733316 "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL";Reactome:R-HSA-9755304 "MUL1 ubiquitinates UBXN7";Reactome:R-HSA-9755505 "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2";Reactome:R-HSA-9759154 "TRIM21 ubiquitinates SQSTM1";Reactome:R-HSA-9759172 "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer";Reactome:R-HSA-9762091 "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1";Reactome:R-HSA-9766645 "CUL3:RBX1 ubiquitinates KEAP1";Reactome:R-HSA-990526 "Recruitment of ITCH and K48 ubiquitination of MAVS" WAS Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL";Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1";Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8";Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE";Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN";Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1";Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2";Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1";Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization";Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation";Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated";Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1";Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1";Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3";Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1";Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1";Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2";Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3";Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4";Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1";Reactome:R-HSA-5674022 "BRAP autoubiquitinates";Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX";Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1";Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal";Reactome:R-HSA-5689111 "PARK2 autoubiquitinates";Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1";Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II";Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC";Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI";Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC";Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2";Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY";Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53";Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4";Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53";Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate";Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination";Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN";Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin";Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex";Reactome:R-HSA-8848829 "CBL autoubiquitinates";Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN";Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA";Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7";Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839";Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR";Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del";Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5";Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET";Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination";Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET";Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex";Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC";Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA";Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10";Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2";Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B";Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA";Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA";Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11";Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN";Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN";Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3";Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3";Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11";Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5";Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73";Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2";Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2";Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2";Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2";Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1";Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3";Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11";Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL";Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation";Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216";Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4";Reactome:R-HSA-9685195 "SARS-CoV-1 9b recruits ITCH to MAVS";Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363";Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2";Reactome:R-HSA-9705738 "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7";Reactome:R-HSA-9706354 "Ubiquitination of FLT3";Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3";Reactome:R-HSA-9708517 "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))";Reactome:R-HSA-9733316 "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL";Reactome:R-HSA-9755304 "MUL1 ubiquitinates UBXN7";Reactome:R-HSA-9755505 "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2";Reactome:R-HSA-9759154 "TRIM21 ubiquitinates SQSTM1";Reactome:R-HSA-9759172 "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer";Reactome:R-HSA-9762091 "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1";Reactome:R-HSA-9766645 "CUL3:RBX1 ubiquitinates KEAP1";Reactome:R-HSA-990526 "Recruitment of ITCH and K48 ubiquitination of MAVS" molecular_function GO:0061665 SUMO ligase activity xrefs Reactome:R-HSA-9834809 "SUMOylation of PKR" WAS N/A molecular_function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating xrefs EC:3.2.2.6;MetaCyc:NADNUCLEOSID-RXN;RHEA:16301 {xref="skos:broadMatch"} WAS EC:3.2.2.6;MetaCyc:NADNUCLEOSID-RXN molecular_function GO:0061995 ATP-dependent protein-DNA complex displacement activity xrefs Reactome:R-HSA-9822115 "NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA" WAS N/A molecular_function GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity xrefs EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9";RESID:AA0026;RHEA:11508 WAS EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;RESID:AA0026;RHEA:11508 molecular_function GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA xrefs Reactome:R-HSA-9820842 "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote" WAS N/A molecular_function GO:0070579 5-methylcytosine dioxygenase activity xrefs EC:1.14.11.80;Reactome:R-HSA-5220952 "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine";Reactome:R-HSA-5220990 "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine";Reactome:R-HSA-5221014 "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine";Reactome:R-HSA-9817458 "TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3";WIkipedia:DNA_demethylation WAS EC:1.14.11.80;Reactome:R-HSA-5220952 "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine";Reactome:R-HSA-5220990 "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine";Reactome:R-HSA-5221014 "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine" molecular_function GO:0070774 phytoceramidase activity xrefs KEGG_REACTION:R06528;MetaCyc:CERAMIDASE-YEAST-RXN;Reactome:R-HSA-428262 "ACER3 hydrolyzes phytoceramide" WAS KEGG_REACTION:R06528;MetaCyc:CERAMIDASE-YEAST-RXN;Reactome:R-HSA-428262 "phytoceramide + H2O => stearate + phytosphingosine" molecular_function GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity xrefs MetaCyc:RXN3DJ-25;Reactome:R-HSA-428664 "SGPP1,2 dephosphorylate sphingoid-1-phosphates";RHEA:27514 WAS MetaCyc:RXN3DJ-25;Reactome:R-HSA-428664 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate";RHEA:27514 molecular_function GO:0070815 peptidyl-lysine 5-dioxygenase activity xrefs Reactome:R-HSA-9630022 "JMJD6 dimer hydroxylates lysine residues of U2AF2" WAS N/A molecular_function GO:0071558 histone H3K27me2/H3K27me3 demethylase activity xrefs EC:1.14.11.68;Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter";Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin";Reactome:R-HSA-5617887 "HOXC4 chromatin is activated";Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)";Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)";RHEA:60224 WAS EC:1.14.11.68;Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter";Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin";Reactome:R-HSA-5617887 "HOXC4 chromatin is activated";RHEA:60224 molecular_function GO:0080049 L-gulono-1,4-lactone dehydrogenase activity xrefs MetaCyc:RXN-1439;RHEA:47248 WAS MetaCyc:RXN-1439 molecular_function GO:0080123 jasmonoyl-L-amino acid ligase activity xrefs EC:6.3.2.52;RHEA:55772 WAS N/A molecular_function GO:0080132 fatty acid alpha-hydroxylase activity xrefs Reactome:R-HSA-5693761 "FA2H hydroxylates 1,2-saturated fatty acids" WAS Reactome:R-HSA-5693761 "FA2H hydroxylates CERA" molecular_function GO:0102682 cytokinin riboside 5'-monophosphate phosphoribohydrolase activity xrefs EC:3.2.2.n1;MetaCyc:RXN-4313;RHEA:48560 WAS MetaCyc:RXN-4313;RHEA:48560 molecular_function GO:0106032 snRNA pseudouridine synthase activity xrefs RHEA:51124 WAS N/A molecular_function GO:0106050 tRNA 2'-O-methyltransferase activity xrefs Reactome:R-HSA-6788668 "TRMT13 2'-O-methylates adenosine-4 in tRNA";Reactome:R-HSA-6788684 "TRMT13 2'-O-methylates cytidine-4 in tRNA";Reactome:R-HSA-9024159 "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)" WAS N/A molecular_function GO:0106155 peptidyl-lysine 3-dioxygenase activity xrefs EC:1.14.11.63;Reactome:R-HSA-9629578 "JMJD7 dimer hydroxlates a lysine residue of DRG2";Reactome:R-HSA-9629591 "JMJD7 dimer hydroxlates a lysine residue of DRG1";RHEA:57152 WAS EC:1.14.11.63;RHEA:57152 molecular_function GO:0106156 peptidyl-lysine 4-dioxygenase activity xrefs Reactome:R-HSA-9629946 "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1";RHEA:57156 WAS RHEA:57156 molecular_function GO:0106157 peptidyl-arginine 3-dioxygenase activity xrefs EC:1.14.11.73;Reactome:R-HSA-9629869 "KDM8:Fe2+ hydroxylates an arginine residue of RPS6";Reactome:R-HSA-9629888 "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1";RHEA:56744 WAS EC:1.14.11.73;RHEA:56744 molecular_function GO:0106310 protein serine kinase activity xrefs Reactome:R-HSA-9729330 "SRPK1/2 phosphorylates nucleoprotein";Reactome:R-HSA-9821967 "SRPK1 phosphorylates PRM2 in PRM2:dsDNA";Reactome:R-HSA-9821982 "SRPK1 phosphorylates PRM1 in PRM1:dsDNA";RHEA:17989 WAS Reactome:R-HSA-9729330 "SRPK1/2 phosphorylates nucleoprotein";RHEA:17989 molecular_function GO:0106316 nitrite reductase NADH activity xrefs EC:1.7.1.15;RHEA:24628 WAS RHEA:24628 molecular_function GO:0120159 rRNA pseudouridine synthase activity xrefs EC:5.4.99.19;EC:5.4.99.20;EC:5.4.99.21;EC:5.4.99.22;EC:5.4.99.23;EC:5.4.99.24;EC:5.4.99.29;EC:5.4.99.43;RHEA:54568 WAS EC:5.4.99.19;EC:5.4.99.20;EC:5.4.99.21;EC:5.4.99.22;EC:5.4.99.23;EC:5.4.99.24;EC:5.4.99.29;EC:5.4.99.43 molecular_function GO:0140104 molecular carrier activity xrefs N/A WAS Reactome:R-HSA-3000074 "TCN2 binds RCbl in the circulation";Reactome:R-HSA-3000120 "CBLIF binds RCbl";Reactome:R-HSA-3132759 "TCN1 binds RCbl" molecular_function GO:0140318 protein transporter activity xrefs Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome";Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network";Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" WAS Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network";Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" molecular_function GO:0140355 cargo receptor ligand activity xrefs Reactome:R-HSA-3000074 "TCN2 binds RCbl in the circulation";Reactome:R-HSA-3000120 "CBLIF binds RCbl";Reactome:R-HSA-3132759 "TCN1 binds RCbl" WAS N/A molecular_function GO:0140713 histone chaperone activity xrefs Reactome:R-HSA-9822185 "HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA" WAS N/A molecular_function GO:0140938 histone H3 methyltransferase activity xrefs Reactome:R-HSA-3788745 "EHMT1:EHMT2 methylates IL8 promoter";Reactome:R-HSA-3788748 "EHMT1:EHMT2 methylates IL6 promoter";Reactome:R-HSA-4827382 "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)";Reactome:R-HSA-4827383 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)";Reactome:R-HSA-5159245 "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)";Reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)";Reactome:R-HSA-5244692 "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)";Reactome:R-HSA-5634729 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)";Reactome:R-HSA-5634750 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)";Reactome:R-HSA-5634802 "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)";Reactome:R-HSA-5637686 "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)";Reactome:R-HSA-5638141 "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)";Reactome:R-HSA-5638157 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)";Reactome:R-HSA-5638332 "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)";Reactome:R-HSA-5638333 "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)";Reactome:R-HSA-5649764 "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)";Reactome:R-HSA-5649799 "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)";Reactome:R-HSA-5649800 "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)";Reactome:R-HSA-5649801 "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)";Reactome:R-HSA-5649802 "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)";Reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3";Reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter";Reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter";Reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter";Reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter" WAS N/A molecular_function GO:0140939 histone H4 methyltransferase activity xrefs Reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)";Reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)";Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)" WAS N/A molecular_function GO:0141035 CTP-dependent diacylglycerol kinase activity xrefs EC:2.7.1.174;KEGG_REACTION:R09944;MetaCyc:RXN-12959;RHEA:25948 WAS EC:2.7.1.174;KEGG_REACTION:R09944;MetaCyc:RXN-12959;Reactome:R-HSA-426240 "DAG kinase produces phosphatidic acid from DAG";RHEA:25948 molecular_function GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity xrefs EC:1.1.1.330;MetaCyc:RXN-7698;Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA";RHEA:48680 WAS EC:1.1.1.330;MetaCyc:RXN-7698;RHEA:48680 molecular_function GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity xrefs EC:2.1.1.214;Reactome:R-HSA-6786501 "TRMT11:TRMT112 methylates guanosine-10 in tRNA";RHEA:43128 WAS EC:2.1.1.214;RHEA:43128 molecular_function GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity xrefs EC:2.1.1.216;Reactome:R-HSA-6782416 "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)";RHEA:43140 WAS EC:2.1.1.216;RHEA:43140 molecular_function GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity xrefs EC:2.1.1.218;Reactome:R-HSA-6787594 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9";RHEA:43148 WAS EC:2.1.1.218;RHEA:43148 molecular_function GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity xrefs EC:2.1.1.220;Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)";Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58";RHEA:43152 WAS EC:2.1.1.220;RHEA:43152 molecular_function GO:1902388 ceramide 1-phosphate transfer activity xrefs Reactome:R-HSA-5339535 "CPTP transports C1P from plasma membrane to Golgi membrane" WAS Reactome:R-HSA-5339535 "GLTPD1 transports C1P from plasma membrane to Golgi membrane" molecular_function GO:1990817 poly(A) RNA polymerase activity xrefs EC:2.7.7.19;MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN;Reactome:R-HSA-72185 "mRNA polyadenylation";Reactome:R-HSA-9833031 "Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs";RHEA:11332 WAS EC:2.7.7.19;MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN;Reactome:R-HSA-72185 "mRNA polyadenylation";RHEA:11332 biological_process GO:0019042 viral latency xrefs VZ:3970 "Viral latency" WAS N/A biological_process GO:0019069 viral capsid assembly xrefs VZ:1950 WAS N/A biological_process GO:0019420 dissimilatory sulfate reduction xrefs MetaCyc:DISSULFRED-PWY;Wikipedia:Sulfate-reducing_microorganism WAS MetaCyc:DISSULFRED-PWY biological_process GO:0032359 provirus excision xrefs VZ:3969 "Viral genome excision" WAS N/A biological_process GO:0039540 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity xrefs VZ:856 WAS N/A biological_process GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity xrefs VZ:704 WAS N/A biological_process GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity xrefs VZ:757 WAS N/A biological_process GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity xrefs VZ:603 WAS N/A biological_process GO:0039557 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity xrefs VZ:653 WAS N/A biological_process GO:0039560 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity xrefs VZ:683 WAS N/A biological_process GO:0039563 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity xrefs VZ:282 WAS N/A biological_process GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity xrefs VZ:257 WAS N/A biological_process GO:0039574 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity xrefs VZ:720 WAS N/A biological_process GO:0039666 virion attachment to host cell pilus xrefs VZ:981 "Viral attachment to host cell pilus" WAS VZ:981 "Pilus-mediated viral adsorption onto host cell" biological_process GO:0039678 symbiont genome ejection through host cell envelope xrefs VZ:986 "Viral genome ejection through host cell envelope" WAS N/A biological_process GO:0039723 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity xrefs VZ:4477 WAS N/A biological_process GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity xrefs VZ:4478 WAS N/A biological_process GO:0042784 symbiont-mediated suppression of host complement activation xrefs VZ:811 WAS N/A biological_process GO:0044071 symbiont-mediated perturbation of host cell cycle progression xrefs VZ:1636 WAS N/A biological_process GO:0046718 symbiont entry into host cell xrefs VZ:936 "Virus entry" WAS VZ:936 biological_process GO:0046924 peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine xrefs PMID:36302388;RESID:AA0340 WAS RESID:AA0340 biological_process GO:0061620 glycolytic process through glucose-6-phosphate xrefs N/A WAS MetaCyc:GLYCOLYSIS biological_process GO:0061633 transport-coupled glycolytic process through glucose-6-phosphate xrefs MetaCyc:GLYCOLYSIS WAS N/A biological_process GO:0075526 cap snatching xrefs VZ:839 "Cap snatching" WAS VZ:839 biological_process GO:0085033 symbiont-mediated activation of host NF-kappaB signal transduction xrefs VZ:841 WAS N/A biological_process GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade xrefs VZ:695 WAS N/A biological_process GO:0098003 viral tail assembly xrefs VZ:3955 "Viral tail assembly" WAS N/A biological_process GO:0098004 virus tail fiber assembly xrefs VZ:3956 "Viral tail fiber assembly" WAS N/A biological_process GO:0098669 superinfection exclusion xrefs VZ:3971 "Superinfection exclusion" WAS VZ:3971 biological_process GO:0098676 modulation of host virulence by virus xrefs VZ:3965 "Modulation of host virulence by virus" WAS N/A biological_process GO:0098677 virion maturation xrefs VZ:1946 WAS UniProtKB-KW:KW-0917;VZ:1946 biological_process GO:0098678 viral tropism switching xrefs VZ:4498 "Viral receptor tropism switching" WAS VZ:4498 biological_process GO:0098689 latency-replication decision xrefs VZ:3964 "Latency-replication decision" WAS VZ:3964 biological_process GO:0099000 symbiont genome ejection through host cell envelope, contractile tail mechanism xrefs VZ:3950 "Viral contractile tail ejection system" WAS VZ:3950 biological_process GO:0099001 symbiont genome ejection through host cell envelope, long flexible tail mechanism xrefs VZ:3952 "Viral long flexible tail ejection system" WAS VZ:3952 biological_process GO:0099002 symbiont genome ejection through host cell envelope, short tail mechanism xrefs VZ:3954 "Viral short tail ejection system" WAS VZ:3954 biological_process GO:0099006 symbiont entry into host cell via permeabilization of endosomal membrane xrefs N/A WAS VZ:985 biological_process GO:0099008 symbiont entry into host cell via permeabilization of inner membrane xrefs N/A WAS VZ:985 biological_process GO:0099009 viral genome circularization xrefs VZ:3968 "Viral genome circularization" WAS VZ:3968 biological_process GO:0099045 viral extrusion xrefs VZ:3951 "Viral extrusion" WAS VZ:3951 biological_process GO:0140267 symbiont entry into host cell via permeabilization of host membrane xrefs VZ:985 "Viral penetration via permeabilization of host membrane" WAS N/A cellular_component GO:0039628 T=169 icosahedral viral capsid xrefs VZ:10117 "T=169 icosahedral capsid" WAS N/A cellular_component GO:0098015 virus tail xrefs VZ:3958 "Viral tail protein" WAS N/A cellular_component GO:0098021 viral capsid, decoration xrefs VZ:4398 "Capsid decoration protein" WAS N/A cellular_component GO:0098024 virus tail, fiber xrefs VZ:4416 "Viral tail fiber protein" WAS N/A cellular_component GO:0098025 virus tail, baseplate xrefs VZ:3957 "Viral baseplate protein" WAS N/A cellular_component GO:0098026 virus tail, tube xrefs VZ:3960 "Viral tail tube protein" WAS N/A cellular_component GO:0098027 virus tail, sheath xrefs VZ:3959 "Viral tail sheath protein" WAS N/A 696 RELATION CHANGES biological_process GO:0000052 citrulline metabolic process is_a GO:0170041;GO:1901605 WAS GO:1901605 biological_process GO:0000053 argininosuccinate metabolic process is_a GO:0006575;GO:0072350;GO:0170033;GO:0170041 WAS GO:0006575;GO:0072350;GO:1901605 biological_process GO:0000162 tryptophan biosynthetic process is_a GO:0006568;GO:0008652;GO:0009073;GO:0046219;GO:1901607 WAS GO:0006568;GO:0009073;GO:0046219;GO:1901607 biological_process GO:0000165 MAPK cascade is_a GO:0141124 WAS GO:0035556 biological_process GO:0000821 regulation of arginine metabolic process is_a GO:0006521 WAS GO:0000820 biological_process GO:0001692 histamine metabolic process is_a GO:0006576;GO:0052803;GO:0097164 WAS GO:0006576;GO:0006796;GO:0052803;GO:0097164 biological_process GO:0006083 acetate metabolic process is_a GO:0032787 WAS GO:0006807;GO:0032787 biological_process GO:0006101 citrate metabolic process is_a GO:0072350 WAS GO:0006807;GO:0072350 biological_process GO:0006520 amino acid metabolic process is_a GO:0044238;GO:0071704 WAS GO:0019752;GO:0044238;GO:1901564 biological_process GO:0006522 alanine metabolic process is_a GO:1901605 WAS GO:0009078 biological_process GO:0006523 alanine biosynthetic process is_a GO:0006522;GO:0008652;GO:1901607 WAS GO:0006522;GO:0009079 biological_process GO:0006524 alanine catabolic process is_a GO:0006522;GO:0009063;GO:1901606 WAS GO:0006522;GO:0009080 biological_process GO:0006525 arginine metabolic process is_a GO:1901605 WAS GO:0009064 biological_process GO:0006534 cysteine metabolic process is_a GO:0000096;GO:1901605 WAS GO:0000096;GO:0009069 biological_process GO:0006536 glutamate metabolic process is_a GO:0009064;GO:0043648 WAS GO:0009064;GO:0043603;GO:0043648 biological_process GO:0006537 glutamate biosynthetic process is_a GO:0006536;GO:0009084;GO:0043650 WAS GO:0006536;GO:0009084;GO:0043604;GO:0043650 biological_process GO:0006547 histidine metabolic process is_a GO:0019752;GO:1901564 WAS GO:0006520 biological_process GO:0006553 lysine metabolic process is_a GO:1901605 WAS GO:0009066 biological_process GO:0006554 lysine catabolic process is_a GO:0006553;GO:0009063;GO:1901606 WAS GO:0006553;GO:0009068 biological_process GO:0006581 acetylcholine catabolic process is_a GO:0008291;GO:1901575 WAS GO:0008291;GO:1901565 biological_process GO:0006591 ornithine metabolic process is_a GO:0170041;GO:1901605 WAS GO:1901605 biological_process GO:0006592 ornithine biosynthetic process is_a GO:0006591;GO:0008652;GO:0170043;GO:1901607 WAS GO:0006591;GO:1901607 biological_process GO:0006593 ornithine catabolic process is_a GO:0006591;GO:0009063;GO:0170044;GO:1901606 WAS GO:0006591;GO:0009063;GO:1901606 biological_process GO:0006604 phosphoarginine metabolic process is_a GO:0006599;GO:0170033;GO:0170041 WAS GO:0006599;GO:1901605 biological_process GO:0006749 glutathione metabolic process is_a GO:0006518;GO:0006575;GO:0006790 WAS GO:0071704 biological_process GO:0006750 glutathione biosynthetic process is_a GO:0006749;GO:0019184;GO:0042398;GO:0044272 WAS GO:0006749;GO:0019184 biological_process GO:0006751 glutathione catabolic process is_a GO:0006749;GO:0042219;GO:0043171;GO:0044273 WAS GO:0006749;GO:1901575 biological_process GO:0006798 polyphosphate catabolic process is_a GO:0006797;GO:0044248;GO:1901575 WAS GO:0006797;GO:0044248 biological_process GO:0006799 polyphosphate biosynthetic process is_a GO:0006797;GO:0044249;GO:1901576 WAS GO:0006797;GO:0044249 biological_process GO:0006816 calcium ion transport is_a GO:0030001 WAS GO:0030001;GO:0071702 biological_process GO:0006833 water transport is_a GO:0042044 WAS GO:0042044;GO:0071702 biological_process GO:0006846 acetate transport is_a GO:0015718 WAS GO:0015718;GO:0071705 biological_process GO:0006850 mitochondrial pyruvate transmembrane transport is_a GO:1901475;GO:1990542 WAS GO:0006839;GO:1901475 biological_process GO:0006851 mitochondrial calcium ion transmembrane transport is_a GO:0070588;GO:1990542 WAS GO:0006839;GO:0070588 biological_process GO:0007249 canonical NF-kappaB signal transduction is_a GO:0141124 WAS GO:0035556 biological_process GO:0007263 nitric oxide mediated signal transduction is_a GO:0141124 WAS GO:0019932 biological_process GO:0007264 small GTPase-mediated signal transduction is_a GO:0141124 WAS GO:0035556 biological_process GO:0007266 Rho protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0008272 sulfate transport is_a GO:0015698;GO:0072348 WAS GO:0015698;GO:0071705;GO:0072348 biological_process GO:0008291 acetylcholine metabolic process is_a GO:0006807;GO:1900619 WAS GO:1900619;GO:1901564 biological_process GO:0008292 acetylcholine biosynthetic process is_a GO:0008291;GO:1900620 WAS GO:0008291;GO:1900620;GO:1901566 biological_process GO:0008652 amino acid biosynthetic process is_a GO:0046394;GO:1901566 WAS GO:0006520;GO:0046394;GO:1901566 biological_process GO:0009063 amino acid catabolic process is_a GO:0046395;GO:1901565 WAS GO:0006520;GO:0046395;GO:1901565 biological_process GO:0009064 glutamine family amino acid metabolic process is_a GO:0170033;GO:0170039 WAS GO:1901605 biological_process GO:0009065 glutamine family amino acid catabolic process is_a GO:0009064;GO:0170035;GO:0170040 WAS GO:0009063;GO:0009064;GO:1901606 biological_process GO:0009066 aspartate family amino acid metabolic process is_a GO:0170033;GO:0170039 WAS GO:1901605 biological_process GO:0009067 aspartate family amino acid biosynthetic process is_a GO:0009066;GO:0170034;GO:0170038 WAS GO:0009066;GO:1901607 biological_process GO:0009068 aspartate family amino acid catabolic process is_a GO:0009066;GO:0170035;GO:0170040 WAS GO:0009063;GO:0009066;GO:1901606 biological_process GO:0009069 serine family amino acid metabolic process is_a GO:0170033;GO:0170039 WAS GO:1901605 biological_process GO:0009070 serine family amino acid biosynthetic process is_a GO:0009069;GO:0170034;GO:0170038 WAS GO:0009069;GO:1901607 biological_process GO:0009071 serine family amino acid catabolic process is_a GO:0009069;GO:0170035;GO:0170040 WAS GO:0009063;GO:0009069;GO:1901606 biological_process GO:0009072 aromatic amino acid metabolic process is_a GO:0006520;GO:0006725;GO:0019752;GO:1901360;GO:1901564 WAS GO:0006520;GO:0006725;GO:1901360 biological_process GO:0009078 pyruvate family amino acid metabolic process is_a GO:0170033;GO:0170039 WAS GO:1901605 biological_process GO:0009079 pyruvate family amino acid biosynthetic process is_a GO:0009078;GO:0170034;GO:0170038 WAS GO:0009078;GO:1901607 biological_process GO:0009080 pyruvate family amino acid catabolic process is_a GO:0009078;GO:0170035;GO:0170040 WAS GO:0009063;GO:0009078;GO:1901606 biological_process GO:0009081 branched-chain amino acid metabolic process is_a GO:0006520;GO:0019752;GO:1901564 WAS GO:0006520 biological_process GO:0009084 glutamine family amino acid biosynthetic process is_a GO:0009064;GO:0170034;GO:0170038 WAS GO:0009064;GO:1901607 biological_process GO:0009093 cysteine catabolic process is_a GO:0000098;GO:0006534;GO:0009063;GO:1901606 WAS GO:0000098;GO:0006534;GO:0009071 biological_process GO:0009256 10-formyltetrahydrofolate metabolic process is_a GO:0043648;GO:0046653 WAS GO:0043648 biological_process GO:0009257 10-formyltetrahydrofolate biosynthetic process is_a GO:0009256;GO:0043650;GO:0046654 WAS GO:0009256;GO:0043650 biological_process GO:0009258 10-formyltetrahydrofolate catabolic process is_a GO:0009256;GO:0009397;GO:0043649 WAS GO:0009256;GO:0043649 biological_process GO:0009415 response to water is_a GO:0001101;GO:0009628;GO:0010035;GO:1901700 WAS GO:0001101;GO:0009628;GO:0010033;GO:0010035;GO:1901700;GO:1902074 biological_process GO:0009448 gamma-aminobutyric acid metabolic process is_a GO:0032787;GO:0170041 WAS GO:0006520;GO:0032787 biological_process GO:0009449 gamma-aminobutyric acid biosynthetic process is_a GO:0008652;GO:0009448;GO:0170043 WAS GO:0008652;GO:0009448 biological_process GO:0009450 gamma-aminobutyric acid catabolic process is_a GO:0009063;GO:0009448;GO:0170044 WAS GO:0009063;GO:0009448 biological_process GO:0009627 systemic acquired resistance is_a GO:0140546 WAS GO:0098542 biological_process GO:0009861 jasmonic acid and ethylene-dependent systemic resistance is_a GO:0009611;GO:0140546 WAS GO:0009611;GO:0098542 biological_process GO:0010034 response to acetate is_a GO:0010033;GO:1901700 WAS GO:0010033;GO:1901698;GO:1901700;GO:1902074 biological_process GO:0010041 response to iron(III) ion is_a GO:0010039 WAS GO:0010039;GO:1902074 biological_process GO:0010133 proline catabolic process to glutamate is_a GO:0006536;GO:0006562 WAS GO:0006536;GO:0006562;GO:0043605 biological_process GO:0010134 sulfate assimilation via adenylyl sulfate reduction is_a GO:0000103 WAS GO:0000103;GO:0019419 relationship has_part GO:0009973 WAS N/A intersection_of is_a GO:0000103;has_part GO:0009973 WAS N/A biological_process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway is_a GO:0045337 WAS GO:0045337;GO:1902767 biological_process GO:0010157 response to chlorate is_a GO:0010035;GO:1901700 WAS GO:0010035;GO:1901700;GO:1902074 biological_process GO:0010167 response to nitrate is_a GO:0010035;GO:1901698;GO:1901700 WAS GO:0010035;GO:1901698;GO:1901700;GO:1902074 biological_process GO:0010226 response to lithium ion is_a GO:0010038 WAS GO:0010038;GO:1901700;GO:1902074 biological_process GO:0010266 response to vitamin B1 is_a GO:0010243;GO:0014070;GO:0033273;GO:0097305 WAS GO:0010243;GO:0014070;GO:0033273;GO:0097305;GO:1902074 biological_process GO:0010323 negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway is_a GO:0010322;GO:0045827;GO:0045912;GO:0071072 WAS GO:0010322;GO:0045827;GO:0045912;GO:0062014;GO:0071072 biological_process GO:0010363 regulation of plant-type hypersensitive response is_a GO:0043067;GO:0045088;GO:0080135 WAS GO:0043067;GO:0043903;GO:0045088;GO:0080135 biological_process GO:0014047 glutamate secretion is_a GO:0006835;GO:0015800;GO:0032940 WAS GO:0006835;GO:0015800;GO:0032940;GO:0042886 biological_process GO:0014060 regulation of epinephrine secretion is_a GO:0051046 WAS GO:0050433 biological_process GO:0015689 molybdate ion transport is_a GO:0015698 WAS GO:0015698;GO:0071705 biological_process GO:0015701 bicarbonate transport is_a GO:0015711 WAS GO:0015711;GO:0019755 biological_process GO:0015709 thiosulfate transport is_a GO:0015698;GO:0072348 WAS GO:0015698;GO:0071705;GO:0072348 biological_process GO:0015724 formate transport is_a GO:0015718 WAS GO:0015718;GO:0019755;GO:0071705 biological_process GO:0015728 mevalonate transport is_a GO:0006810 WAS GO:0015718;GO:0015850 biological_process GO:0015730 propanoate transmembrane transport is_a GO:0015913 WAS GO:0015913;GO:0071705 biological_process GO:0015745 tartrate transmembrane transport is_a GO:0015740;GO:0034219;GO:0042869 WAS GO:0015740;GO:0034219;GO:0042869;GO:0072348 biological_process GO:0015746 citrate transport is_a GO:0006842 WAS GO:0006842;GO:0071705 biological_process GO:0015870 acetylcholine transport is_a GO:0015695;GO:0071705;GO:1901374 WAS GO:0015695;GO:0015697;GO:1901374 biological_process GO:0015871 choline transport is_a GO:0015695;GO:0071705 WAS GO:0015695;GO:0015697 biological_process GO:0015942 formate metabolic process is_a GO:0032787 WAS GO:0006807;GO:0032787 biological_process GO:0016226 iron-sulfur cluster assembly is_a GO:0031163 WAS GO:0006790;GO:0031163 biological_process GO:0016601 Rac protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0018396 peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine is_a GO:0006575;GO:0017185;GO:0170033;GO:0170041 WAS GO:0006575;GO:0017185;GO:1901605 biological_process GO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline is_a GO:0006575;GO:0019511;GO:0046483;GO:0170033;GO:0170041;GO:1901360 WAS GO:0006575;GO:0019511;GO:0046483;GO:1901360;GO:1901605 biological_process GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline is_a GO:0019471;GO:0019511;GO:0170033 WAS GO:0019471;GO:0019511 biological_process GO:0018864 acetylene metabolic process is_a GO:0006805;GO:0043452;GO:0120244 WAS GO:0006805;GO:0018942;GO:0043452;GO:0120244 biological_process GO:0018871 1-aminocyclopropane-1-carboxylate metabolic process is_a GO:0170041;GO:1901605 WAS GO:1901605 biological_process GO:0018901 2,4-dichlorophenoxyacetic acid metabolic process is_a GO:0018904;GO:0032787;GO:0042537 WAS GO:0018904;GO:0032787;GO:0042537;GO:1901564 biological_process GO:0019050 suppression by virus of host apoptotic process is_a GO:0019048;GO:0044068 WAS GO:0019054 biological_process GO:0019051 induction by virus of host apoptotic process is_a GO:0019048;GO:0044068 WAS GO:0019054 biological_process GO:0019054 modulation by virus of host cellular process is_a GO:0019048 WAS GO:0019048;GO:0044068 intersection_of N/A WAS is_a GO:0019048;regulates GO:0009987 biological_process GO:0019090 mitochondrial rRNA export from mitochondrion is_a GO:0051029;GO:0170037 WAS GO:0006839;GO:0051029;GO:0055085 biological_process GO:0019240 citrulline biosynthetic process is_a GO:0000052;GO:0170043;GO:1901607 WAS GO:0000052;GO:1901607 biological_process GO:0019241 citrulline catabolic process is_a GO:0000052;GO:0044270;GO:0170044;GO:1901606 WAS GO:0000052;GO:0044270;GO:1901606 biological_process GO:0019279 L-methionine biosynthetic process from L-homoserine via cystathionine is_a GO:0009092;GO:0071266;GO:0170041 WAS GO:0009092;GO:0071266 biological_process GO:0019283 L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine is_a GO:0006575;GO:0006796;GO:0019637;GO:0071266;GO:0170041 WAS GO:0006575;GO:0006796;GO:0019637;GO:0071266 biological_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway is_a GO:0009240;GO:0019682 WAS GO:0006090;GO:0009240;GO:0019682 biological_process GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) is_a GO:0000103 WAS GO:0000103;GO:0019419 relationship has_part GO:0004604 WAS N/A intersection_of is_a GO:0000103;has_part GO:0004604 WAS N/A biological_process GO:0019420 dissimilatory sulfate reduction is_a GO:0000103;GO:0009061 WAS GO:0019419 biological_process GO:0019448 L-cysteine catabolic process is_a GO:0009071;GO:0009093;GO:0046439 WAS GO:0009093;GO:0042219;GO:0046439 biological_process GO:0019470 4-hydroxyproline catabolic process is_a GO:0009063;GO:0019471;GO:0042219;GO:0046700;GO:0170044;GO:1901361;GO:1901606 WAS GO:0009063;GO:0019471;GO:0042219;GO:0046700;GO:1901361;GO:1901606 biological_process GO:0019471 4-hydroxyproline metabolic process is_a GO:0006575;GO:0046483;GO:0170041;GO:1901360;GO:1901605 WAS GO:0006575;GO:0046483;GO:1901360;GO:1901605 biological_process GO:0019472 4-hydroxyproline biosynthetic process is_a GO:0008652;GO:0018130;GO:0019471;GO:0042398;GO:0170043;GO:1901362;GO:1901607 WAS GO:0018130;GO:0019471;GO:0042398;GO:1901362;GO:1901607 biological_process GO:0019477 L-lysine catabolic process is_a GO:0006554;GO:0009068;GO:0046440 WAS GO:0006554;GO:0046440 biological_process GO:0019478 D-amino acid catabolic process is_a GO:0009063;GO:0046416;GO:0170044;GO:1901606 WAS GO:0009063;GO:0046416;GO:1901606 biological_process GO:0019482 beta-alanine metabolic process is_a GO:0170041 WAS GO:0006520 biological_process GO:0019483 beta-alanine biosynthetic process is_a GO:0008652;GO:0019482;GO:0170043 WAS GO:0008652;GO:0019482 biological_process GO:0019484 beta-alanine catabolic process is_a GO:0009063;GO:0019482;GO:0170044 WAS GO:0009063;GO:0019482 biological_process GO:0019499 cyanide metabolic process is_a GO:0034641;GO:0071704 WAS GO:0034641;GO:1901564 biological_process GO:0019500 cyanide catabolic process is_a GO:0019499;GO:0044270;GO:1901575 WAS GO:0019499;GO:0044270;GO:1901565 biological_process GO:0019502 L-proline betaine metabolic process is_a GO:0006577;GO:0009820;GO:0170033;GO:0170041 WAS GO:0006577;GO:0009820;GO:1901605 biological_process GO:0019503 L-proline betaine biosynthetic process is_a GO:0006578;GO:0009821;GO:0019502;GO:0170034;GO:0170043 WAS GO:0006578;GO:0009821;GO:0019502;GO:1901607 biological_process GO:0019504 L-proline betaine catabolic process is_a GO:0006579;GO:0009822;GO:0019502;GO:0170035;GO:0170044 WAS GO:0006579;GO:0009063;GO:0009822;GO:0019502;GO:1901606 biological_process GO:0019510 S-adenosylhomocysteine catabolic process is_a GO:0042219;GO:0044273;GO:0046130;GO:0046498;GO:0170035;GO:0170044 WAS GO:0009063;GO:0042219;GO:0044273;GO:0046130;GO:0046498;GO:1901606 biological_process GO:0019521 D-gluconate metabolic process is_a GO:0019520 WAS GO:0009311;GO:0019520 biological_process GO:0019532 oxalate transport is_a GO:0006835 WAS GO:0006835;GO:0071705 biological_process GO:0019541 propionate metabolic process is_a GO:0046459 WAS GO:0006807;GO:0046459 biological_process GO:0019544 arginine catabolic process to glutamate is_a GO:0006527;GO:0006536 WAS GO:0006527;GO:0006536;GO:0043605 biological_process GO:0019557 histidine catabolic process to glutamate and formate is_a GO:0006536;GO:0006548;GO:0015942 WAS GO:0006536;GO:0006548;GO:0015942;GO:0043605 biological_process GO:0019651 citrate catabolic process to diacetyl is_a GO:0006101;GO:0019662;GO:0042180;GO:0072352 WAS GO:0006101;GO:0019662;GO:0019666;GO:0042180;GO:0072352 biological_process GO:0019654 acetate fermentation is_a GO:0006083;GO:0006113 WAS GO:0006083;GO:0019666 biological_process GO:0019695 choline metabolic process is_a GO:0071704;GO:0097164 WAS GO:0097164;GO:1901564 biological_process GO:0019722 calcium-mediated signaling is_a GO:0141124 WAS GO:0019932 biological_process GO:0019730 antimicrobial humoral response is_a GO:0006959;GO:0140546 WAS GO:0006959;GO:0098542 biological_process GO:0019749 cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte is_a GO:0030705 WAS GO:0007303;GO:0030705 intersection_of N/A WAS is_a GO:0007303;is_a GO:0030705 biological_process GO:0019872 streptomycin biosynthetic process is_a GO:0030648;GO:0046173;GO:0046343 WAS GO:0030648;GO:0044272;GO:0046173;GO:0046343 biological_process GO:0019935 cyclic-nucleotide-mediated signaling is_a GO:0141124 WAS GO:0019932 biological_process GO:0020013 modulation by symbiont of host erythrocyte aggregation intersection_of is_a GO:0044068;regulates GO:0034117 WAS is_a GO:0044003;regulates GO:0034117 biological_process GO:0030150 protein import into mitochondrial matrix is_a GO:0044743;GO:0072655;GO:0170036 WAS GO:0044743;GO:0072655;GO:1990542 biological_process GO:0030205 dermatan sulfate metabolic process is_a GO:0006790;GO:0032787;GO:1903510 WAS GO:0005996;GO:0006790;GO:0032787;GO:0052779;GO:1903510 biological_process GO:0030208 dermatan sulfate biosynthetic process is_a GO:0006024;GO:0030205;GO:0044272;GO:0072330 WAS GO:0006024;GO:0030205;GO:0044272;GO:0046364;GO:0072330 biological_process GO:0030209 dermatan sulfate catabolic process is_a GO:0006027;GO:0030205;GO:0044273;GO:0072329 WAS GO:0006027;GO:0030205;GO:0044273;GO:0046365;GO:0052782;GO:0072329 biological_process GO:0030393 fructoselysine metabolic process is_a GO:0019752;GO:0030389;GO:1901564 WAS GO:0006520;GO:0030389 biological_process GO:0030417 nicotianamine metabolic process is_a GO:0006520;GO:0006576;GO:0046483;GO:0072350;GO:1901360 WAS GO:0006576;GO:0046483;GO:0072350;GO:1901360 biological_process GO:0031028 septation initiation signaling is_a GO:0007264 WAS GO:0007265 biological_process GO:0031029 regulation of septation initiation signaling is_a GO:0051056 WAS GO:0046578 biological_process GO:0031030 negative regulation of septation initiation signaling is_a GO:0010974;GO:0031029;GO:0051058 WAS GO:0010974;GO:0031029;GO:0046580 biological_process GO:0031031 positive regulation of septation initiation signaling is_a GO:0010973;GO:0031029;GO:0051057 WAS GO:0010973;GO:0031029;GO:0046579 biological_process GO:0031291 Ran protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0031427 response to methotrexate is_a GO:0010243;GO:0014070;GO:1901700 WAS GO:0010243;GO:0014070;GO:1901700;GO:1902074 biological_process GO:0032011 ARF protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0032012 regulation of ARF protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0032013 negative regulation of ARF protein signal transduction is_a GO:0032012;GO:0051058 WAS GO:0032012;GO:0046580 biological_process GO:0032014 positive regulation of ARF protein signal transduction is_a GO:0032012;GO:0051057 WAS GO:0032012;GO:0046579 biological_process GO:0032482 Rab protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0032483 regulation of Rab protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0032484 Ral protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0032485 regulation of Ral protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0032486 Rap protein signal transduction is_a GO:0007264 WAS GO:0007265 biological_process GO:0032487 regulation of Rap protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0032811 negative regulation of epinephrine secretion is_a GO:0014060;GO:0051048 WAS GO:0014060;GO:0033604 biological_process GO:0032812 positive regulation of epinephrine secretion is_a GO:0014060;GO:0051047 WAS GO:0014060;GO:0033605 biological_process GO:0033052 cyanoamino acid metabolic process is_a GO:0050898;GO:0170041 WAS GO:0019752;GO:0050898 biological_process GO:0033054 D-glutamate metabolic process is_a GO:0006536;GO:0046416 WAS GO:0006536;GO:0043170;GO:0046416 biological_process GO:0033198 response to ATP is_a GO:0014074;GO:0046683;GO:1901700 WAS GO:0014074;GO:0046683;GO:1901700;GO:1902074 biological_process GO:0033274 response to vitamin B2 is_a GO:0010243;GO:0014070;GO:0033273;GO:1901700 WAS GO:0010243;GO:0014070;GO:0033273;GO:1901700;GO:1902074 biological_process GO:0033321 homomethionine metabolic process is_a GO:0019752;GO:1901564 WAS GO:0006520 biological_process GO:0033487 pelargonidin 3-O-glucoside biosynthetic process is_a GO:0009813;GO:1901806 WAS GO:0009718;GO:1901806 biological_process GO:0033507 glucosinolate biosynthetic process from phenylalanine is_a GO:0019752;GO:0019761 WAS GO:0006520;GO:0019761 biological_process GO:0033591 response to L-ascorbic acid is_a GO:0014070;GO:0033273;GO:0034284 WAS GO:0014070;GO:0033273;GO:0034284;GO:1902074 biological_process GO:0033609 oxalate metabolic process is_a GO:0043648 WAS GO:0006807;GO:0043648 biological_process GO:0034050 symbiont-induced defense-related programmed cell death is_a GO:0012501;GO:0140546 WAS GO:0012501;GO:0051702;GO:0098542 biological_process GO:0034267 discadenine metabolic process is_a GO:0009690;GO:0072521;GO:0170033;GO:0170041 WAS GO:0009690;GO:0072521;GO:1901605 biological_process GO:0034268 discadenine biosynthetic process is_a GO:0009691;GO:0034267;GO:0072522;GO:0170034;GO:0170043 WAS GO:0009691;GO:0034267;GO:0072522;GO:1901607 biological_process GO:0034269 discadenine catabolic process is_a GO:0009823;GO:0034267;GO:0072523;GO:0170035;GO:0170044 WAS GO:0009063;GO:0009823;GO:0034267;GO:0072523;GO:1901606 biological_process GO:0034635 glutathione transport is_a GO:0015711;GO:0042939;GO:0072337;GO:0072348 WAS GO:0015711 biological_process GO:0034775 glutathione transmembrane transport is_a GO:0034635;GO:0035443 WAS GO:0034635;GO:0055085 biological_process GO:0035020 regulation of Rac protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0035021 negative regulation of Rac protein signal transduction is_a GO:0035020;GO:0051058 WAS GO:0035020;GO:0046580 biological_process GO:0035022 positive regulation of Rac protein signal transduction is_a GO:0035020;GO:0051057 WAS GO:0035020;GO:0046579 biological_process GO:0035023 regulation of Rho protein signal transduction is_a GO:0051056 WAS GO:0046578 biological_process GO:0035024 negative regulation of Rho protein signal transduction is_a GO:0035023;GO:0051058 WAS GO:0035023;GO:0046580 biological_process GO:0035025 positive regulation of Rho protein signal transduction is_a GO:0035023;GO:0051057 WAS GO:0035023;GO:0046579 biological_process GO:0035498 carnosine metabolic process is_a GO:0006518;GO:0006520;GO:0019752 WAS GO:0006518;GO:0019752 biological_process GO:0035864 response to potassium ion is_a GO:0010038 WAS GO:0010038;GO:1901700;GO:1902074 biological_process GO:0035865 cellular response to potassium ion is_a GO:0035864;GO:0071248 WAS GO:0035864;GO:0071248;GO:1901701;GO:1902075 biological_process GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway is_a GO:0002753 WAS GO:0030522 biological_process GO:0035891 exit from host cell is_a GO:0051701 WAS GO:0044000 biological_process GO:0035927 RNA import into mitochondrion is_a GO:0050658;GO:0170036 WAS GO:0050658;GO:1990542 biological_process GO:0036088 D-serine catabolic process is_a GO:0019478;GO:0070178 WAS GO:0009071;GO:0019478;GO:0070178 biological_process GO:0036255 response to methylamine is_a GO:0014075 WAS GO:0014075;GO:1902074 biological_process GO:0036256 cellular response to methylamine is_a GO:0036255;GO:0071418 WAS GO:0036255;GO:0071418;GO:1902075 biological_process GO:0036272 response to gemcitabine is_a GO:0010243;GO:0014070;GO:1901700 WAS GO:0010243;GO:0014070;GO:1901700;GO:1902074 biological_process GO:0036280 cellular response to L-canavanine is_a GO:0071230;GO:1901354 WAS GO:0071230;GO:1901354;GO:1902075 biological_process GO:0036346 cellular response to L-cysteine is_a GO:0071230;GO:1901367 WAS GO:0071230;GO:1901367;GO:1902075 biological_process GO:0036444 calcium import into the mitochondrion is_a GO:0006851;GO:0170036 WAS GO:0006851;GO:1990542 biological_process GO:0038061 non-canonical NF-kappaB signal transduction is_a GO:0141124 WAS GO:0035556 biological_process GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway is_a GO:0140886 WAS GO:0141077 relationship N/A WAS negatively_regulates GO:0060337 intersection_of N/A WAS is_a GO:0019054;negatively_regulates GO:0060337 biological_process GO:0039505 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II is_a GO:0002587;GO:0039588 WAS GO:0002587;GO:0039588;GO:0050794 biological_process GO:0039514 symbiont-mediated suppression of host JAK-STAT cascade is_a GO:0052029 WAS GO:0141075 biological_process GO:0039525 modulation by virus of host chromatin organization is_a GO:0019048;GO:0044068 WAS GO:0019054 biological_process GO:0039527 symbiont-mediated suppression of host TRAF-mediated signal transduction is_a GO:0052029 WAS GO:0141076 biological_process GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway is_a GO:0039503;GO:0052078;GO:0075111 WAS GO:0039503;GO:0075111 biological_process GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling is_a GO:0019057;GO:0052029 WAS GO:0019057;GO:0039503 biological_process GO:0039592 symbiont-mediated arrest of host cell cycle during G2/M transition is_a GO:0044071 WAS GO:0060153 biological_process GO:0039593 symbiont-mediated perturbation of host exit from mitosis is_a GO:0044071 WAS GO:0060153 biological_process GO:0039645 symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint is_a GO:0044071 WAS GO:0060153 biological_process GO:0039646 symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint is_a GO:0044071 WAS GO:0060153 biological_process GO:0039648 symbiont-mediated perturbation of host protein ubiquitination is_a GO:0044068 WAS GO:0019054 relationship N/A WAS regulates GO:0016567 intersection_of N/A WAS is_a GO:0019048;regulates GO:0016567 biological_process GO:0039656 modulation by virus of host gene expression is_a GO:0019054;GO:0044068 WAS GO:0019054 biological_process GO:0039666 virion attachment to host cell pilus relationship part_of GO:0046718 WAS N/A biological_process GO:0039672 suppression by virus of host natural killer cell activation is_a GO:0032815;GO:0039671;GO:0044068 WAS GO:0032815;GO:0039671 biological_process GO:0039678 symbiont genome ejection through host cell envelope is_a GO:0016032 WAS GO:0046718 relationship part_of GO:0046718 WAS N/A biological_process GO:0039699 evasion of mRNA degradation by host via mRNA cap methylation is_a GO:0141043 WAS GO:0039503 biological_process GO:0039722 symbiont-mediated suppression of host toll-like receptor signaling pathway is_a GO:0039503;GO:0052029 WAS GO:0039503;GO:0141105 biological_process GO:0042217 1-aminocyclopropane-1-carboxylate catabolic process is_a GO:0009063;GO:0018871;GO:0170044;GO:1901606 WAS GO:0009063;GO:0018871;GO:1901606 biological_process GO:0042218 1-aminocyclopropane-1-carboxylate biosynthetic process is_a GO:0008652;GO:0018871;GO:0170043;GO:1901607 WAS GO:0018871;GO:1901607 biological_process GO:0042220 response to cocaine is_a GO:0014070;GO:0043279;GO:1901700 WAS GO:0014070;GO:0043279;GO:1901700;GO:1902074 biological_process GO:0042414 epinephrine metabolic process is_a GO:0008152 WAS GO:0006584 biological_process GO:0042418 epinephrine biosynthetic process is_a GO:0009058;GO:0042414 WAS GO:0042414;GO:0042423 biological_process GO:0042419 epinephrine catabolic process is_a GO:0009056;GO:0042414 WAS GO:0042414;GO:0042424 biological_process GO:0042542 response to hydrogen peroxide is_a GO:0000302;GO:0010035 WAS GO:0000302;GO:0010033;GO:0010035 biological_process GO:0042743 hydrogen peroxide metabolic process is_a GO:0072593 WAS GO:0071704;GO:0072593 biological_process GO:0042744 hydrogen peroxide catabolic process is_a GO:0042743;GO:0044248 WAS GO:0042743;GO:0044248;GO:1901575 biological_process GO:0042784 symbiont-mediated suppression of host complement activation is_a GO:0052170 WAS GO:0042783 biological_process GO:0042851 L-alanine metabolic process is_a GO:0006522;GO:0009078 WAS GO:0006522 biological_process GO:0042852 L-alanine biosynthetic process is_a GO:0006523;GO:0009079;GO:0042851 WAS GO:0006523;GO:0042851 biological_process GO:0042853 L-alanine catabolic process is_a GO:0006524;GO:0009080;GO:0042851 WAS GO:0006524;GO:0042851 biological_process GO:0042854 eugenol metabolic process is_a GO:0009698;GO:0018904;GO:0018958;GO:0042537;GO:0120254 WAS GO:0009698;GO:0018904;GO:0018958;GO:0042537 biological_process GO:0042855 eugenol biosynthetic process is_a GO:0009699;GO:0042854;GO:0046189;GO:0120255;GO:1901503 WAS GO:0009699;GO:0042854;GO:0046189;GO:1901503 biological_process GO:0042856 eugenol catabolic process is_a GO:0019336;GO:0042854;GO:0046271;GO:0120256;GO:1901502 WAS GO:0019336;GO:0042854;GO:0046271;GO:1901502 biological_process GO:0042956 maltodextrin transmembrane transport is_a GO:0042955 WAS GO:0015774 biological_process GO:0043278 response to morphine is_a GO:0014072 WAS GO:0014072;GO:1902074 biological_process GO:0043418 homocysteine catabolic process is_a GO:0000098;GO:0009063;GO:0050667;GO:0170044;GO:1901606 WAS GO:0000098;GO:0009063;GO:0050667;GO:1901606 biological_process GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction is_a GO:0141124 WAS GO:0035556 biological_process GO:0044001 migration in host is_a GO:0051701 WAS GO:0044000 biological_process GO:0044029 positive regulation of gene expression via CpG island demethylation is_a GO:0141137 WAS GO:0045815 biological_process GO:0044071 symbiont-mediated perturbation of host cell cycle progression relationship N/A WAS regulates GO:0022402 intersection_of N/A WAS is_a GO:0044068;regulates GO:0022402 biological_process GO:0044073 modulation by symbiont of host translation is_a GO:0044068 WAS GO:0006417;GO:0044068 biological_process GO:0044074 negative regulation by symbiont of host translation is_a GO:0044073 WAS GO:0017148;GO:0044073 biological_process GO:0044079 modulation by symbiont of host neurotransmitter secretion intersection_of is_a GO:0044068;regulates GO:0007269 WAS is_a GO:0044003;regulates GO:0007269 biological_process GO:0044083 symbiont-mediated perturbation of host Rho signal transduction is_a GO:0044082 WAS GO:0035023;GO:0044082 biological_process GO:0044409 symbiont entry into host is_a GO:0051701 WAS GO:0044000 biological_process GO:0044523 envenomation resulting in damage of muscle extracellular matrix in another organism is_a GO:0044521;GO:0141041 WAS GO:0044521 biological_process GO:0044694 symbiont genome entry into host cell via pore formation in plasma membrane is_a GO:0052008 WAS GO:0046718;GO:0046794 relationship part_of GO:0046718 WAS has_part GO:0039707 biological_process GO:0044758 modulation by symbiont of host synaptic transmission intersection_of is_a GO:0044068;regulates GO:0007268 WAS is_a GO:0044003;regulates GO:0007268 biological_process GO:0044863 modulation by virus of host cell division is_a GO:0019054;GO:0044068;GO:0051302 WAS GO:0019054;GO:0051302 biological_process GO:0045016 mitochondrial magnesium ion transmembrane transport is_a GO:1903830;GO:1990542 WAS GO:0006839;GO:1903830 biological_process GO:0045041 protein import into mitochondrial intermembrane space is_a GO:0044743;GO:0072655;GO:1990542 WAS GO:0006839;GO:0044743;GO:0072655 biological_process GO:0045087 innate immune response is_a GO:0006955;GO:0140546 WAS GO:0006955;GO:0098542 biological_process GO:0045734 regulation of acetate catabolic process is_a GO:0010565;GO:0031329 WAS GO:0010565;GO:0031329;GO:0051171 biological_process GO:0045753 negative regulation of acetate catabolic process is_a GO:0031330;GO:0045734;GO:0062014 WAS GO:0031330;GO:0045734;GO:0051172;GO:0062014 biological_process GO:0045754 positive regulation of acetate catabolic process is_a GO:0031331;GO:0045734;GO:0062013 WAS GO:0031331;GO:0045734;GO:0051173;GO:0062013 biological_process GO:0045763 negative regulation of cellular amino acid metabolic process is_a GO:0006521;GO:0033239 WAS GO:0006521;GO:0031324;GO:0033239;GO:0062014 biological_process GO:0045764 positive regulation of amino acid metabolic process is_a GO:0006521;GO:0033240 WAS GO:0006521;GO:0031325;GO:0033240;GO:0062013 biological_process GO:0045815 transcription initiation-coupled chromatin remodeling is_a GO:0141137 WAS GO:0006338 biological_process GO:0046177 D-gluconate catabolic process is_a GO:0016052;GO:0019521;GO:0046176 WAS GO:0009313;GO:0019521;GO:0046176 biological_process GO:0046178 D-gluconate biosynthetic process is_a GO:0016051;GO:0019521;GO:0046175 WAS GO:0009312;GO:0019521;GO:0046175 biological_process GO:0046202 cyanide biosynthetic process is_a GO:0019499;GO:0044271;GO:1901576 WAS GO:0019499;GO:0044271;GO:1901566 biological_process GO:0046300 2,4-dichlorophenoxyacetic acid catabolic process is_a GO:0018901;GO:0019439;GO:0072329;GO:1901361;GO:1901502 WAS GO:0018901;GO:0019439;GO:0072329;GO:1901361;GO:1901502;GO:1901565 biological_process GO:0046312 phosphoarginine biosynthetic process is_a GO:0006604;GO:0042396;GO:0170034;GO:0170043 WAS GO:0006604;GO:0042396;GO:1901607 biological_process GO:0046313 phosphoarginine catabolic process is_a GO:0006604;GO:0042397;GO:0170035;GO:0170044 WAS GO:0006604;GO:0009063;GO:0042397;GO:1901606 biological_process GO:0046343 streptomycin metabolic process is_a GO:0019751;GO:0030647 WAS GO:0006790;GO:0006807;GO:0019751;GO:0030647 biological_process GO:0046416 D-amino acid metabolic process is_a GO:0170041;GO:1901605 WAS GO:1901605 biological_process GO:0046418 nopaline metabolic process is_a GO:0006575;GO:0019752 WAS GO:0006520;GO:0006575 biological_process GO:0046437 D-amino acid biosynthetic process is_a GO:0008652;GO:0046416;GO:0170043;GO:1901607 WAS GO:0046416;GO:1901607 biological_process GO:0046439 L-cysteine metabolic process is_a GO:0006534;GO:0009069 WAS GO:0006534;GO:0006575 biological_process GO:0046440 L-lysine metabolic process is_a GO:0006553;GO:0009066 WAS GO:0006553 biological_process GO:0046444 FMN metabolic process is_a GO:0009161;GO:0009259;GO:0042726 WAS GO:0009161;GO:0009259;GO:0042726;GO:0052648 biological_process GO:0046498 S-adenosylhomocysteine metabolic process is_a GO:0006575;GO:0006790;GO:0046128;GO:0170033;GO:0170041 WAS GO:0006575;GO:0006790;GO:0046128;GO:1901605 biological_process GO:0046516 hypusine metabolic process is_a GO:0006575;GO:0170033;GO:0170041 WAS GO:0006575;GO:1901605 biological_process GO:0046679 response to streptomycin is_a GO:0046677;GO:1903416 WAS GO:0046677;GO:1901698;GO:1902074;GO:1903416 biological_process GO:0046687 response to chromate is_a GO:0010035;GO:1901700 WAS GO:0010035;GO:1901700;GO:1902074 biological_process GO:0046946 hydroxylysine metabolic process is_a GO:0006575;GO:0009066;GO:0170041 WAS GO:0006575;GO:0009066 biological_process GO:0046947 hydroxylysine biosynthetic process is_a GO:0009067;GO:0042398;GO:0046946;GO:0170043 WAS GO:0009067;GO:0042398;GO:0046946 biological_process GO:0046948 hydroxylysine catabolic process is_a GO:0009068;GO:0042219;GO:0046946;GO:0170044 WAS GO:0009068;GO:0042219;GO:0046946 biological_process GO:0048241 epinephrine transport is_a GO:0006810 WAS GO:0051937 biological_process GO:0048242 epinephrine secretion is_a GO:0046903;GO:0048241 WAS GO:0048241;GO:0050432 biological_process GO:0048250 iron import into the mitochondrion is_a GO:0034755;GO:0170036 WAS GO:0034755;GO:1990542 biological_process GO:0050665 hydrogen peroxide biosynthetic process is_a GO:0042743;GO:0044249;GO:1903409 WAS GO:0042743;GO:0044249;GO:1901576;GO:1903409 biological_process GO:0050667 homocysteine metabolic process is_a GO:0000096;GO:0170041;GO:1901605 WAS GO:0000096;GO:1901605 biological_process GO:0050992 dimethylallyl diphosphate biosynthetic process is_a GO:0008654;GO:0050993 WAS GO:0050993;GO:1901576 biological_process GO:0050993 dimethylallyl diphosphate metabolic process is_a GO:0006644 WAS GO:0006793;GO:0071704 biological_process GO:0051592 response to calcium ion is_a GO:0010038 WAS GO:0010033;GO:0010038;GO:1901700;GO:1902074 biological_process GO:0051625 epinephrine uptake is_a GO:0048241 WAS GO:0048241;GO:0090493 biological_process GO:0051873 killing by host of symbiont cells is_a GO:0031640;GO:0051702;GO:0140546 WAS GO:0031640;GO:0051702;GO:0098542 biological_process GO:0051938 L-glutamate import is_a GO:0006835;GO:0015800;GO:0015807 WAS GO:0006835;GO:0015800;GO:0015807;GO:0042886 biological_process GO:0051958 methotrexate transport is_a GO:0006835;GO:0042886 WAS GO:0006835;GO:0042886;GO:0072337 biological_process GO:0052003 symbiont-mediated suppression of defense-related host salicylic acid-mediated signal transduction pathway is_a GO:0009968;GO:0010113;GO:0044414;GO:0052081;GO:0052089 WAS GO:0009968;GO:0010113;GO:0044414;GO:0052029;GO:0052081;GO:0052089 biological_process GO:0052009 symbiont-mediated disruption of host cell wall is_a GO:0044278;GO:0098933 WAS GO:0044278;GO:0052008 biological_process GO:0052027 symbiont-mediated perturbation of host signal transduction pathway is_a GO:0044068 WAS GO:0044068;GO:0044501 biological_process GO:0052064 symbiont-mediated activation of reactive oxygen species production in host cell is_a GO:0141132 WAS GO:0052559 biological_process GO:0052078 symbiont-mediated suppression of host pathogen-associated molecular pattern receptor signaling pathway is_a GO:0052029 WAS GO:0044414;GO:0075111 biological_process GO:0052103 induction of host induced systemic resistance is_a GO:0052159 WAS GO:0052159;GO:0052390 biological_process GO:0052708 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process is_a GO:0006577;GO:0170033;GO:0170041 WAS GO:0006577;GO:1901605 biological_process GO:0052709 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process is_a GO:0006578;GO:0052708;GO:0170034;GO:0170043 WAS GO:0006578;GO:0052708;GO:1901607 biological_process GO:0052710 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process is_a GO:0006579;GO:0052708;GO:0170035;GO:0170044 WAS GO:0006579;GO:0009063;GO:0052708;GO:1901606 biological_process GO:0060141 positive regulation of syncytium formation by virus is_a GO:0019054;GO:0044068;GO:0060140;GO:0060143 WAS GO:0019054;GO:0060140;GO:0060143 biological_process GO:0060395 SMAD protein signal transduction is_a GO:0141124 WAS GO:0035556 biological_process GO:0060919 auxin import into cell is_a GO:0060918;GO:0098739 WAS GO:0060918;GO:0098657;GO:0098739 biological_process GO:0061529 epinephrine secretion, neurotransmission is_a GO:0007269;GO:0048242 WAS GO:0048242;GO:0160043 biological_process GO:0062133 negative regulation of L-glutamine biosynthetic process is_a GO:0045763;GO:0062132;GO:2000283 WAS GO:0062132;GO:2000283 biological_process GO:0062134 positive regulation of L-glutamine biosynthetic process is_a GO:0045764;GO:0062132;GO:2000284 WAS GO:0062132;GO:2000284 biological_process GO:0062142 L-beta-ethynylserine biosynthetic process is_a GO:0120237;GO:0170034;GO:0170043 WAS GO:0120237;GO:1901607 biological_process GO:0062143 L-propargylglycine biosynthetic process is_a GO:0120237;GO:0170034;GO:0170043 WAS GO:0120237;GO:1901607 biological_process GO:0070098 chemokine-mediated signaling pathway is_a GO:0007186;GO:0019221 WAS GO:0019221 biological_process GO:0070099 regulation of chemokine-mediated signaling pathway is_a GO:0001959;GO:0008277 WAS GO:0001959 biological_process GO:0070100 negative regulation of chemokine-mediated signaling pathway is_a GO:0001960;GO:0045744;GO:0070099 WAS GO:0001960;GO:0070099 biological_process GO:0070101 positive regulation of chemokine-mediated signaling pathway is_a GO:0001961;GO:0045745;GO:0070099 WAS GO:0001961;GO:0070099 biological_process GO:0070178 D-serine metabolic process is_a GO:0046416 WAS GO:0009069;GO:0046416 biological_process GO:0070179 D-serine biosynthetic process is_a GO:0046437;GO:0070178 WAS GO:0009070;GO:0046437;GO:0070178 biological_process GO:0070189 kynurenine metabolic process is_a GO:0042180;GO:0042537;GO:0170041;GO:1901605 WAS GO:0042180;GO:0042537;GO:1901605 biological_process GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway relationship regulates GO:0035872 WAS regulates GO:0070423 intersection_of is_a GO:0065007;regulates GO:0035872 WAS is_a GO:0065007;regulates GO:0070423 biological_process GO:0070425 negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway relationship negatively_regulates GO:0035872 WAS negatively_regulates GO:0070423 intersection_of is_a GO:0065007;negatively_regulates GO:0035872 WAS is_a GO:0065007;negatively_regulates GO:0070423 biological_process GO:0070426 positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway relationship positively_regulates GO:0035872 WAS positively_regulates GO:0070423 intersection_of is_a GO:0065007;positively_regulates GO:0035872 WAS is_a GO:0065007;positively_regulates GO:0070423 biological_process GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway is_a GO:0035872 WAS GO:0070423 biological_process GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway is_a GO:0035872 WAS GO:0070423 biological_process GO:0070543 response to linoleic acid is_a GO:0070542 WAS GO:0070542;GO:1902074 biological_process GO:0071239 cellular response to streptomycin is_a GO:0046679;GO:0071236;GO:1901701 WAS GO:0046679;GO:0071236;GO:1901699;GO:1901701;GO:1902075 biological_process GO:0071246 cellular response to chlorate is_a GO:0010157;GO:0071241;GO:1901701 WAS GO:0010157;GO:0071241;GO:1901701;GO:1902075 biological_process GO:0071247 cellular response to chromate is_a GO:0046687;GO:0071241;GO:1901701 WAS GO:0046687;GO:0071241;GO:1901701;GO:1902075 biological_process GO:0071249 cellular response to nitrate is_a GO:0010167;GO:0071241;GO:1901701;GO:1902170 WAS GO:0010167;GO:0071241;GO:1901701;GO:1902075;GO:1902170 biological_process GO:0071268 homocysteine biosynthetic process is_a GO:0000097;GO:0008652;GO:0050667;GO:0170043;GO:1901607 WAS GO:0000097;GO:0050667;GO:1901607 biological_process GO:0071272 morphine metabolic process is_a GO:0033076;GO:1901376 WAS GO:0006790;GO:0033076;GO:1901376 biological_process GO:0071273 morphine catabolic process is_a GO:0071272;GO:0071274;GO:1901377 WAS GO:0044273;GO:0071272;GO:0071274;GO:1901377 biological_process GO:0071277 cellular response to calcium ion is_a GO:0051592;GO:0071248 WAS GO:0051592;GO:0071248;GO:1901701;GO:1902075 biological_process GO:0071283 cellular response to iron(III) ion is_a GO:0010041;GO:0071281 WAS GO:0010041;GO:0071281;GO:1902075 biological_process GO:0071285 cellular response to lithium ion is_a GO:0010226;GO:0071248 WAS GO:0010226;GO:0071248;GO:1901701;GO:1902075 biological_process GO:0071298 cellular response to L-ascorbic acid is_a GO:0033591;GO:0071295;GO:0071326;GO:0071407 WAS GO:0033591;GO:0071295;GO:0071326;GO:0071407;GO:1902075 biological_process GO:0071301 cellular response to vitamin B1 is_a GO:0010266;GO:0071295;GO:0071407;GO:0071417;GO:0097306 WAS GO:0010266;GO:0071295;GO:0071407;GO:0071417;GO:0097306;GO:1902075 biological_process GO:0071302 cellular response to vitamin B2 is_a GO:0033274;GO:0071295;GO:0071407;GO:0071417;GO:1901701 WAS GO:0033274;GO:0071295;GO:0071407;GO:0071417;GO:1901701;GO:1902075 biological_process GO:0071311 cellular response to acetate is_a GO:0010034;GO:0071310;GO:1901701 WAS GO:0010034;GO:0071310;GO:1901699;GO:1901701;GO:1902075 biological_process GO:0071314 cellular response to cocaine is_a GO:0042220;GO:0071312;GO:0071407;GO:1901701 WAS GO:0042220;GO:0071312;GO:0071407;GO:1901701;GO:1902075 biological_process GO:0071315 cellular response to morphine is_a GO:0043278;GO:0071317 WAS GO:0043278;GO:0071317;GO:1902075 biological_process GO:0071318 cellular response to ATP is_a GO:0033198;GO:0071407;GO:0071417;GO:1901701 WAS GO:0033198;GO:0071407;GO:0071417;GO:1901701;GO:1902075 biological_process GO:0071319 cellular response to benzoic acid is_a GO:0071407;GO:0080021;GO:1901701 WAS GO:0071407;GO:0080021;GO:1901701;GO:1902075 biological_process GO:0071399 cellular response to linoleic acid is_a GO:0070543;GO:0071398 WAS GO:0070543;GO:0071398;GO:1902075 biological_process GO:0071414 cellular response to methotrexate is_a GO:0031427;GO:0071407;GO:0071417;GO:1901701 WAS GO:0031427;GO:0071407;GO:0071417;GO:1901701;GO:1902075 biological_process GO:0071462 cellular response to water stimulus is_a GO:0009415;GO:0071214;GO:0071229;GO:1901701 WAS GO:0009415;GO:0071214;GO:0071229;GO:1901701;GO:1902075 biological_process GO:0071505 response to mycophenolic acid is_a GO:0014070;GO:1901700 WAS GO:0014070;GO:1901700;GO:1902074 biological_process GO:0071506 cellular response to mycophenolic acid is_a GO:0071407;GO:0071505;GO:1901701 WAS GO:0071407;GO:0071505;GO:1901701;GO:1902075 biological_process GO:0071524 pyrrolysine biosynthetic process is_a GO:0018130;GO:0042398;GO:0043604;GO:0071525;GO:0170038;GO:1901362 WAS GO:0018130;GO:0042398;GO:0043604;GO:0046394;GO:0071525;GO:1901362 biological_process GO:0071525 pyrrolysine metabolic process is_a GO:0006575;GO:0043603;GO:0046483;GO:0170039;GO:1901360 WAS GO:0006575;GO:0019752;GO:0043603;GO:0046483;GO:1901360 biological_process GO:0071871 response to epinephrine is_a GO:0042221 WAS GO:0071869 biological_process GO:0071872 cellular response to epinephrine stimulus is_a GO:0070887;GO:0071871 WAS GO:0071870;GO:0071871 biological_process GO:0071993 phytochelatin transport is_a GO:0015711;GO:0015833 WAS GO:0015833 biological_process GO:0072706 response to sodium dodecyl sulfate is_a GO:0010033;GO:1901700 WAS GO:0010033;GO:1901700;GO:1902074 biological_process GO:0072707 cellular response to sodium dodecyl sulfate is_a GO:0071310;GO:0072706;GO:1901701 WAS GO:0071310;GO:0072706;GO:1901701;GO:1902075 biological_process GO:0072753 cellular response to glutathione is_a GO:1901370;GO:1901653 WAS GO:0070887;GO:1901370 biological_process GO:0072756 cellular response to paraquat is_a GO:0071310;GO:1901562 WAS GO:0071310;GO:1901562;GO:1902075 biological_process GO:0075111 symbiont-mediated suppression of host receptor-mediated signal transduction is_a GO:0075109 WAS GO:0052029;GO:0075109 biological_process GO:0075118 symbiont-mediated perturbation of host G protein-coupled receptor signal transduction pathway is_a GO:0075109 WAS GO:0052028;GO:0075112 biological_process GO:0075120 symbiont-mediated suppression of host G protein-coupled receptor signal transduction is_a GO:0075118 WAS GO:0052029;GO:0075118 biological_process GO:0075135 symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction is_a GO:0075133 WAS GO:0052029;GO:0075133 biological_process GO:0080021 response to benzoic acid is_a GO:0014070;GO:1901700 WAS GO:0014070;GO:1901700;GO:1902074 biological_process GO:0080170 hydrogen peroxide transmembrane transport is_a GO:0055085 WAS GO:0055085;GO:0071702 biological_process GO:0080185 effector-mediated activation of plant hypersensitive response by symbiont is_a GO:0052042;GO:0052158;GO:0140404 WAS GO:0034053;GO:0052042;GO:0052158;GO:0052390;GO:0140404 biological_process GO:0085017 entry into host cell by a symbiont-containing vacuole is_a GO:0046718 WAS GO:0044409 biological_process GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade is_a GO:0085032 WAS GO:0052029;GO:0085032 biological_process GO:0089718 amino acid import across plasma membrane is_a GO:0003333;GO:0098739 WAS GO:0003333;GO:0098657;GO:0098739 biological_process GO:0090358 positive regulation of tryptophan metabolic process is_a GO:0031325;GO:0045764;GO:0062013;GO:0090357 WAS GO:0045764;GO:0090357 biological_process GO:0090374 oligopeptide export from mitochondrion is_a GO:0035672;GO:0170037 WAS GO:0006839;GO:0035672 biological_process GO:0090454 glutamate transmembrane import into vacuole is_a GO:0006835;GO:0015800;GO:0032975 WAS GO:0006835;GO:0015800;GO:0032975;GO:0042886 biological_process GO:0097052 L-kynurenine metabolic process is_a GO:0070189;GO:0170033 WAS GO:0070189 biological_process GO:0097053 L-kynurenine catabolic process is_a GO:0019439;GO:0042182;GO:0097052;GO:0170035;GO:0170044;GO:1901361 WAS GO:0009063;GO:0019439;GO:0042182;GO:0097052;GO:1901361;GO:1901606 biological_process GO:0097068 response to thyroxine is_a GO:0014070;GO:0043200;GO:0097066;GO:1904386 WAS GO:0014070;GO:0043200;GO:0097066;GO:1902074;GO:1904386 biological_process GO:0097069 cellular response to thyroxine stimulus is_a GO:0071230;GO:0071407;GO:0097067;GO:0097068;GO:1904387 WAS GO:0071230;GO:0071407;GO:0097067;GO:0097068;GO:1902075;GO:1904387 biological_process GO:0097184 response to azide is_a GO:0010035;GO:1901698 WAS GO:0010035;GO:1901698;GO:1902074 biological_process GO:0097185 cellular response to azide is_a GO:0071241;GO:0097184;GO:1901699 WAS GO:0071241;GO:0097184;GO:1901699;GO:1902075 biological_process GO:0097295 morphine biosynthetic process is_a GO:0033075;GO:0071272;GO:1901378 WAS GO:0033075;GO:0044272;GO:0071272;GO:1901378 biological_process GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway is_a GO:0006516;GO:0036503;GO:1904587 WAS GO:0006516;GO:0030433;GO:1904587 biological_process GO:0097638 L-arginine import across plasma membrane is_a GO:0089718;GO:1902475 WAS GO:0072337;GO:0089718;GO:1902475 biological_process GO:0098672 suppression of host CRISPR-cas system is_a GO:0052170 WAS GO:0019049 relationship N/A WAS negatively_regulates GO:0099048 biological_process GO:0098702 adenine import across plasma membrane is_a GO:0015853;GO:0098739;GO:1904823 WAS GO:0015853;GO:0098657;GO:0098739;GO:1904823 biological_process GO:0098704 carbohydrate import across plasma membrane is_a GO:0034219;GO:0098739 WAS GO:0034219;GO:0098657;GO:0098739 biological_process GO:0098709 glutathione import across plasma membrane is_a GO:0034775;GO:0140207 WAS GO:0034775;GO:0098657;GO:0098739 biological_process GO:0098710 guanine import across plasma membrane is_a GO:0098739;GO:1903716 WAS GO:0098657;GO:0098739;GO:1903716 biological_process GO:0098714 malate import across plasma membrane is_a GO:0071423;GO:0098739 WAS GO:0071423;GO:0098657;GO:0098739 biological_process GO:0098715 malonic acid import across plasma membrane is_a GO:0098739;GO:1901553 WAS GO:0098657;GO:0098739;GO:1901553 biological_process GO:0098717 pantothenate import across plasma membrane is_a GO:0015887;GO:0098739 WAS GO:0015887;GO:0098657;GO:0098739 biological_process GO:0098720 succinate import across plasma membrane is_a GO:0071422;GO:0098739 WAS GO:0071422;GO:0098657;GO:0098739 biological_process GO:0098721 uracil import across plasma membrane is_a GO:0098739;GO:1903791 WAS GO:0098657;GO:0098739;GO:1903791 biological_process GO:0098739 import across plasma membrane is_a GO:0055085;GO:0098657 WAS GO:0055085 biological_process GO:0098932 symbiont entry into host cell via disruption of host cell wall peptidoglycan is_a GO:0052009 WAS GO:0019048;GO:0052009 biological_process GO:0098994 symbiont entry into host cell via disruption of host cell envelope relationship part_of GO:0046718 WAS N/A biological_process GO:0098995 symbiont entry into host cell via disruption of host cell envelope lipopolysaccharide is_a GO:0052009 WAS GO:0019048;GO:0052009 biological_process GO:0099001 symbiont genome ejection through host cell envelope, long flexible tail mechanism is_a GO:0039678 WAS GO:0039678;GO:0046794 biological_process GO:0099002 symbiont genome ejection through host cell envelope, short tail mechanism is_a GO:0039678 WAS GO:0039678;GO:0046794 biological_process GO:0099016 evasion of DNA end degradation by host is_a GO:0141043 WAS GO:0019049 biological_process GO:0099018 evasion of host restriction-modification system is_a GO:0141043 WAS GO:0019049 biological_process GO:0099046 clearance of foreign intracellular nucleic acids is_a GO:0140546 WAS GO:0098542 biological_process GO:0099093 calcium export from the mitochondrion is_a GO:0006851;GO:0051209;GO:0170037 WAS GO:0006851;GO:0051209 biological_process GO:0099587 inorganic ion import across plasma membrane is_a GO:0098660;GO:0098739 WAS GO:0098657;GO:0098660;GO:0098739 biological_process GO:0099636 cytoplasmic streaming is_a GO:0046907 WAS GO:0016482 biological_process GO:0110141 L-glutamate import into mitochondrion is_a GO:0015813;GO:0170036 WAS GO:0015813;GO:1990542 biological_process GO:0140021 mitochondrial ADP transmembrane transport is_a GO:0015866;GO:0072530;GO:1901679;GO:1990542 WAS GO:0006839;GO:0015866;GO:0072530;GO:1901679 biological_process GO:0140125 thiamine import across plasma membrane is_a GO:0071934;GO:0098739 WAS GO:0071934;GO:0098657;GO:0098739 biological_process GO:0140140 mitochondrial guanine nucleotide transmembrane transport is_a GO:1903716;GO:1990542 WAS GO:0006839;GO:1903716 biological_process GO:0140141 mitochondrial potassium ion transmembrane transport is_a GO:0071805;GO:1990542 WAS GO:0006839;GO:0071805 biological_process GO:0140196 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process is_a GO:0051240;GO:0071879;GO:0106071 WAS GO:0051240;GO:0071879;GO:0106071;GO:0140192 biological_process GO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process is_a GO:0051241;GO:0071878 WAS GO:0051241;GO:0071878;GO:0140192 biological_process GO:0140201 urea import across plasma membrane is_a GO:0071918;GO:0098739 WAS GO:0071918;GO:0098657;GO:0098739 biological_process GO:0140202 polyamine import across plasma membrane is_a GO:0071702;GO:0071705;GO:0098739 WAS GO:0071702;GO:0071705;GO:0098657;GO:0098739 biological_process GO:0140204 pyridoxal import across plasma membrane is_a GO:0098739;GO:1903090 WAS GO:0098657;GO:0098739;GO:1903090 biological_process GO:0140205 oligopeptide import across plasma membrane is_a GO:0035672;GO:0098739 WAS GO:0035672;GO:0098657;GO:0098739 biological_process GO:0140267 symbiont entry into host cell via permeabilization of host membrane is_a GO:0052008 WAS GO:0046718 relationship part_of GO:0046718 WAS N/A biological_process GO:0140270 gluconate import across plasma membrane is_a GO:0035429;GO:0098739 WAS GO:0035429;GO:0098657;GO:0098739 biological_process GO:0140300 serine import into mitochondrion is_a GO:0003333;GO:0032329;GO:0170036 WAS GO:0003333;GO:0032329;GO:1990542 biological_process GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane is_a GO:0015711;GO:0015868;GO:0051503;GO:0070729;GO:0098739;GO:1903790 WAS GO:0015711;GO:0015868;GO:0051503;GO:0070729;GO:0098657;GO:0098739;GO:1903790 biological_process GO:0140466 iron-sulfur cluster export from the mitochondrion is_a GO:1902497;GO:1990542 WAS GO:0006839;GO:1902497 biological_process GO:0140636 copper import into the mitochondrion is_a GO:0035434;GO:0170036 WAS GO:0035434;GO:1990542 biological_process GO:0140884 symbiont-mediated suppression of host type II interferon-mediated signaling pathway is_a GO:0140886 WAS GO:0141077 relationship N/A WAS negatively_regulates GO:0060333 intersection_of N/A WAS is_a GO:0019054;negatively_regulates GO:0060333 biological_process GO:0140885 symbiont-mediated suppression of host type III interferon-mediated signaling pathway is_a GO:0140886 WAS GO:0141077 relationship N/A WAS negatively_regulates GO:0038196 intersection_of N/A WAS is_a GO:0019054;negatively_regulates GO:0038196 biological_process GO:0140886 symbiont-mediated suppression of host interferon-mediated signaling pathway is_a GO:0052029 WAS GO:0141077 biological_process GO:0140917 zinc ion import into mitochondrion is_a GO:0062111;GO:0170036 WAS GO:0062111;GO:1990542 biological_process GO:0141070 symbiont-mediated suppression of host MAPK cascade is_a GO:0052080 WAS GO:0052029;GO:0052080 biological_process GO:0141104 symbiont-mediated activation of host G protein-coupled receptor signal transduction is_a GO:0052028;GO:0075118 WAS GO:0075118 biological_process GO:0160007 glutathione import into mitochondrion is_a GO:0034775;GO:0170036 WAS GO:0034775;GO:1990542 biological_process GO:0180015 nucleoside import across plasma membrane is_a GO:0098739;GO:1901642 WAS GO:0098657;GO:0098739;GO:1901642 biological_process GO:1900079 regulation of arginine biosynthetic process is_a GO:0000820;GO:0000821;GO:2000282 WAS GO:0000821;GO:2000282 biological_process GO:1900080 positive regulation of arginine biosynthetic process is_a GO:0045764;GO:1900079;GO:2000284 WAS GO:1900079;GO:2000284 biological_process GO:1900081 regulation of arginine catabolic process is_a GO:0000820;GO:0000821;GO:0031329;GO:0033241 WAS GO:0000821;GO:0031329;GO:0033241 biological_process GO:1900082 negative regulation of arginine catabolic process is_a GO:0031330;GO:0033242;GO:0045763;GO:0062014;GO:1900081 WAS GO:0031330;GO:0033242;GO:0045763;GO:1900081 biological_process GO:1900177 regulation of aflatoxin biosynthetic process is_a GO:0031326;GO:0062012;GO:1900376 WAS GO:0031326;GO:0051171;GO:0062012;GO:1900376 biological_process GO:1900178 negative regulation of aflatoxin biosynthetic process is_a GO:0031327;GO:0062014;GO:1900177;GO:1900377 WAS GO:0031327;GO:0051172;GO:0062014;GO:1900177;GO:1900377 biological_process GO:1900179 positive regulation of aflatoxin biosynthetic process is_a GO:0031328;GO:0062013;GO:1900177;GO:1900378 WAS GO:0031328;GO:0051173;GO:0062013;GO:1900177;GO:1900378 biological_process GO:1900339 regulation of methane biosynthetic process from formic acid is_a GO:0010565;GO:0043457;GO:1901577 WAS GO:0010565;GO:0043457;GO:0051171;GO:1901577 biological_process GO:1900340 negative regulation of methane biosynthetic process from formic acid is_a GO:0062014;GO:1900339;GO:1901578;GO:1901856 WAS GO:0051172;GO:0062014;GO:1900339;GO:1901578;GO:1901856 biological_process GO:1900341 positive regulation of methane biosynthetic process from formic acid is_a GO:0062013;GO:1900339;GO:1901579;GO:1901857 WAS GO:0051173;GO:0062013;GO:1900339;GO:1901579;GO:1901857 biological_process GO:1900994 (-)-secologanin biosynthetic process is_a GO:0016099;GO:0018130;GO:0046184;GO:0120255;GO:1901362;GO:1901806 WAS GO:0016099;GO:0018130;GO:0046184;GO:0120255;GO:1900992;GO:1901362;GO:1901806 biological_process GO:1901009 (S)-scoulerine biosynthetic process is_a GO:0018130;GO:0033075;GO:1901362 WAS GO:0018130;GO:0033075;GO:1901007;GO:1901362 biological_process GO:1901012 (S)-reticuline biosynthetic process is_a GO:0009708;GO:0018130;GO:1901362;GO:1901617 WAS GO:0009708;GO:0018130;GO:1901010;GO:1901362;GO:1901617 biological_process GO:1901052 sarcosine metabolic process is_a GO:0006575;GO:0170041;GO:1901605 WAS GO:0006575;GO:1901605 biological_process GO:1901053 sarcosine catabolic process is_a GO:0009063;GO:0042219;GO:0170044;GO:1901052;GO:1901606 WAS GO:0009063;GO:0042219;GO:1901052;GO:1901606 biological_process GO:1901054 sarcosine biosynthetic process is_a GO:0008652;GO:0042398;GO:0170043;GO:1901052;GO:1901607 WAS GO:0042398;GO:1901052;GO:1901607 biological_process GO:1901055 trimethylenediamine metabolic process is_a GO:0006595 WAS GO:0006807;GO:0071704 biological_process GO:1901056 trimethylenediamine catabolic process is_a GO:0006598;GO:1901055 WAS GO:1901055;GO:1901575 biological_process GO:1901057 trimethylenediamine biosynthetic process is_a GO:0006596;GO:1901055 WAS GO:1901055;GO:1901576 biological_process GO:1901085 pyrrolizidine alkaloid biosynthetic process is_a GO:0009821 WAS GO:0009821;GO:1901083 biological_process GO:1901103 gramicidin S biosynthetic process is_a GO:0043043 WAS GO:0043043;GO:1901101 biological_process GO:1901150 vistamycin metabolic process is_a GO:0006807;GO:0019751;GO:0030647 WAS GO:0006790;GO:0006807;GO:0019751;GO:0030647 biological_process GO:1901151 vistamycin catabolic process is_a GO:0030649;GO:0046174;GO:1901150 WAS GO:0030649;GO:0044273;GO:0046174;GO:1901150 biological_process GO:1901152 vistamycin biosynthetic process is_a GO:0030648;GO:0046173;GO:1901150 WAS GO:0030648;GO:0044272;GO:0046173;GO:1901150 biological_process GO:1901354 response to L-canavanine is_a GO:0043200 WAS GO:0043200;GO:1902074 biological_process GO:1901367 response to L-cysteine is_a GO:0043200 WAS GO:0043200;GO:1902074 biological_process GO:1901370 response to glutathione is_a GO:1901652 WAS GO:0010033 biological_process GO:1901425 response to formic acid is_a GO:0010033;GO:1901700 WAS GO:0010033;GO:1901698;GO:1901700;GO:1902074 biological_process GO:1901530 response to hypochlorite is_a GO:0000302;GO:0010035 WAS GO:0000302;GO:0010035;GO:1902074 biological_process GO:1901562 response to paraquat is_a GO:0010033 WAS GO:0010033;GO:1902074 biological_process GO:1901605 alpha-amino acid metabolic process is_a GO:0006520;GO:0019752;GO:1901564 WAS GO:0006520 biological_process GO:1901607 alpha-amino acid biosynthetic process is_a GO:0046394;GO:1901566;GO:1901605 WAS GO:0008652;GO:1901605 biological_process GO:1901710 regulation of homoserine biosynthetic process is_a GO:0006521;GO:2000282 WAS GO:2000282 biological_process GO:1901711 negative regulation of homoserine biosynthetic process is_a GO:0045763;GO:1901710;GO:2000283 WAS GO:1901710;GO:2000283 biological_process GO:1901712 positive regulation of homoserine biosynthetic process is_a GO:0045764;GO:1901710;GO:2000284 WAS GO:1901710;GO:2000284 biological_process GO:1901716 negative regulation of gamma-aminobutyric acid catabolic process is_a GO:0031330;GO:0045763;GO:0062014;GO:1901715 WAS GO:0031330;GO:0045763;GO:1901715 biological_process GO:1901717 positive regulation of gamma-aminobutyric acid catabolic process is_a GO:0031331;GO:0045764;GO:0062013;GO:1901715 WAS GO:0031331;GO:0045764;GO:1901715 biological_process GO:1901905 response to tamsulosin is_a GO:0014070;GO:0014075;GO:0045472 WAS GO:0014070;GO:0014075;GO:0045472;GO:1902074 biological_process GO:1901975 glycerate transmembrane transport is_a GO:0034219;GO:0042873 WAS GO:0042873 biological_process GO:1901997 negative regulation of indoleacetic acid biosynthetic process via tryptophan is_a GO:0032353;GO:0045763;GO:0062014;GO:0090356;GO:1901996 WAS GO:0032353;GO:0045763;GO:0090356;GO:1901996 biological_process GO:1902061 betaine aldehyde metabolic process is_a GO:0006807;GO:0071704 WAS GO:1901564 biological_process GO:1902062 betaine aldehyde catabolic process is_a GO:1901575;GO:1902061 WAS GO:1901565;GO:1902061 biological_process GO:1902063 betaine aldehyde biosynthetic process is_a GO:1901576;GO:1902061 WAS GO:1901566;GO:1902061 biological_process GO:1902065 response to L-glutamate is_a GO:0043200 WAS GO:0043200;GO:1902074 biological_process GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process is_a GO:0170033;GO:0170039 WAS GO:1901605 biological_process GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process is_a GO:0170035;GO:0170040;GO:1902221 WAS GO:0009063;GO:1901606;GO:1902221 biological_process GO:1902223 erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process is_a GO:0170034;GO:0170038;GO:1902221 WAS GO:1901607;GO:1902221 biological_process GO:1902349 response to chloroquine is_a GO:0010243;GO:0014070 WAS GO:0010243;GO:0014070;GO:1902074 biological_process GO:1902350 cellular response to chloroquine is_a GO:0071407;GO:0071417;GO:1902349 WAS GO:0071407;GO:0071417;GO:1902075;GO:1902349 biological_process GO:1902438 response to vanadate(3-) is_a GO:0010035;GO:1901700 WAS GO:0010035;GO:1901700;GO:1902074 biological_process GO:1902439 cellular response to vanadate(3-) is_a GO:1901701;GO:1902438 WAS GO:1901701;GO:1902075;GO:1902438 biological_process GO:1902617 response to fluoride is_a GO:0010035 WAS GO:0010035;GO:1901700;GO:1902074 biological_process GO:1902618 cellular response to fluoride is_a GO:0070887;GO:1902617 WAS GO:1901701;GO:1902075;GO:1902617 biological_process GO:1902986 regulation of lysine biosynthetic process via aminoadipic acid is_a GO:0006521;GO:2000282 WAS GO:2000282 biological_process GO:1902987 negative regulation of lysine biosynthetic process via aminoadipic acid is_a GO:0045763;GO:1902986;GO:2000283 WAS GO:1902986;GO:2000283 biological_process GO:1903075 pyridoxine import across plasma membrane is_a GO:0098739;GO:1903092 WAS GO:0098657;GO:0098739;GO:1903092 biological_process GO:1903184 L-dopa metabolic process is_a GO:0006575;GO:0009072;GO:0170033;GO:0170041 WAS GO:0006575;GO:0009072;GO:1901605 biological_process GO:1903185 L-dopa biosynthetic process is_a GO:0009073;GO:0042398;GO:0170034;GO:0170043;GO:1903184 WAS GO:0009073;GO:0042398;GO:1901607;GO:1903184 biological_process GO:1903195 regulation of L-dopa biosynthetic process is_a GO:0006521;GO:2000282 WAS GO:2000282 biological_process GO:1903196 negative regulation of L-dopa biosynthetic process is_a GO:0045763;GO:1903195;GO:2000283 WAS GO:1903195;GO:2000283 biological_process GO:1903197 positive regulation of L-dopa biosynthetic process is_a GO:0045764;GO:1903195;GO:2000284 WAS GO:1903195;GO:2000284 biological_process GO:1903248 regulation of citrulline biosynthetic process is_a GO:0006521;GO:0031326 WAS GO:2000282 biological_process GO:1903249 negative regulation of citrulline biosynthetic process is_a GO:0031327;GO:0045763;GO:0062014;GO:1903248 WAS GO:1903248;GO:2000283 biological_process GO:1903250 positive regulation of citrulline biosynthetic process is_a GO:0031328;GO:0045764;GO:0062013;GO:1903248 WAS GO:1903248;GO:2000284 biological_process GO:1903252 hercynylcysteine sulfoxide metabolic process is_a GO:0006790;GO:0052701;GO:0170033 WAS GO:0006790;GO:0052701;GO:1901605 biological_process GO:1903253 hercynylcysteine sulfoxide biosynthetic process is_a GO:0044272;GO:0052703;GO:0170034;GO:1903252 WAS GO:0044272;GO:0052703;GO:1901607;GO:1903252 biological_process GO:1903254 hercynylselenocysteine metabolic process is_a GO:0001887;GO:0052701;GO:0170033 WAS GO:0001887;GO:0052701;GO:1901605 biological_process GO:1903255 hercynylselenocysteine biosynthetic process is_a GO:0052703;GO:0170034;GO:1903254 WAS GO:0052703;GO:1901607;GO:1903254 biological_process GO:1903267 negative regulation of ornithine catabolic process is_a GO:0031330;GO:0045763;GO:0062014;GO:1903266 WAS GO:0031330;GO:0045763;GO:1903266 biological_process GO:1903268 positive regulation of ornithine catabolic process is_a GO:0031331;GO:0045764;GO:0062013;GO:1903266 WAS GO:0031331;GO:0045764;GO:1903266 biological_process GO:1903329 regulation of iron-sulfur cluster assembly is_a GO:0044087;GO:0051128 WAS GO:0042762;GO:0044087;GO:0051128 biological_process GO:1903330 negative regulation of iron-sulfur cluster assembly is_a GO:0051129;GO:1903329 WAS GO:0051129;GO:0051175;GO:1903329 biological_process GO:1903331 positive regulation of iron-sulfur cluster assembly is_a GO:0051130;GO:1903329 WAS GO:0051130;GO:0051176;GO:1903329 biological_process GO:1903493 response to clopidogrel is_a GO:0010243;GO:0014070;GO:1901700 WAS GO:0010243;GO:0014070;GO:1901700;GO:1902074 biological_process GO:1903544 response to butyrate is_a GO:0070542 WAS GO:0070542;GO:1902074 biological_process GO:1903545 cellular response to butyrate is_a GO:0071398;GO:1903544 WAS GO:0071398;GO:1902075;GO:1903544 biological_process GO:1903558 3-cyano-L-alanine metabolic process is_a GO:0033052;GO:0170033 WAS GO:0033052;GO:1901605 biological_process GO:1903559 3-cyano-L-alanine catabolic process is_a GO:0050899;GO:0170035;GO:0170044;GO:1903558 WAS GO:0009063;GO:0050899;GO:1901606;GO:1903558 biological_process GO:1903560 3-cyano-L-alanine biosynthetic process is_a GO:0080028;GO:0170034;GO:0170043;GO:1903558 WAS GO:0080028;GO:1901607;GO:1903558 biological_process GO:1903652 modulation by virus of host cytoplasmic transport relationship N/A WAS regulates GO:0016482 intersection_of N/A WAS is_a GO:0019054;regulates GO:0016482 biological_process GO:1903786 regulation of glutathione biosynthetic process is_a GO:0031326;GO:0034248;GO:0042762 WAS GO:0031326;GO:0034248 biological_process GO:1903787 negative regulation of glutathione biosynthetic process is_a GO:0031327;GO:0034249;GO:0051175;GO:1903786 WAS GO:0031327;GO:0034249;GO:1903786 biological_process GO:1903788 positive regulation of glutathione biosynthetic process is_a GO:0031328;GO:0034250;GO:0051176;GO:1903786 WAS GO:0031328;GO:0034250;GO:1903786 biological_process GO:1903826 L-arginine transmembrane transport is_a GO:1902475;GO:1990822 WAS GO:0072337;GO:1902475;GO:1990822 biological_process GO:1903927 response to cyanide is_a GO:0010033 WAS GO:0010243;GO:1902074 biological_process GO:1903928 cellular response to cyanide is_a GO:0070887;GO:1903927 WAS GO:0071417;GO:1902075;GO:1903927 biological_process GO:1904187 regulation of transformation of host cell by virus is_a GO:0043903;GO:0050792 WAS GO:0043903;GO:0050792;GO:0050794 biological_process GO:1904313 response to methamphetamine hydrochloride is_a GO:0014075 WAS GO:0014075;GO:1902074 biological_process GO:1904314 cellular response to methamphetamine hydrochloride is_a GO:0071418;GO:1904313 WAS GO:0071418;GO:1902075;GO:1904313 biological_process GO:1904447 folate import across plasma membrane is_a GO:0098739;GO:0098838 WAS GO:0098657;GO:0098739;GO:0098838 biological_process GO:1904679 myo-inositol import across plasma membrane is_a GO:0015791;GO:0015798;GO:0098739 WAS GO:0015791;GO:0015798;GO:0098657;GO:0098739 biological_process GO:1904732 regulation of electron transfer activity is_a GO:0043467;GO:0065009 WAS GO:0043467;GO:0051341 biological_process GO:1904733 negative regulation of electron transfer activity is_a GO:0044092;GO:1904732 WAS GO:0051354;GO:1904732 biological_process GO:1904734 positive regulation of electron transfer activity is_a GO:0044093;GO:1904732 WAS GO:0051353;GO:1904732 biological_process GO:1904809 regulation of dense core granule transport is_a GO:0032386 WAS GO:1903649 biological_process GO:1904810 negative regulation of dense core granule transport is_a GO:0032387;GO:1904809 WAS GO:1903650;GO:1904809 biological_process GO:1904811 positive regulation of dense core granule transport is_a GO:0032388;GO:1904809 WAS GO:1903651;GO:1904809 biological_process GO:1904947 folate import into mitochondrion is_a GO:0098838;GO:0170036 WAS GO:0098838;GO:1990542 biological_process GO:1904959 regulation of cytochrome-c oxidase activity is_a GO:0010155;GO:0032412;GO:0051341;GO:1904732 WAS GO:0010155;GO:0032412;GO:1904732 biological_process GO:1904960 positive regulation of cytochrome-c oxidase activity is_a GO:0032414;GO:0051353;GO:1904734;GO:1904959 WAS GO:0032414;GO:1904734;GO:1904959 biological_process GO:1904983 glycine import into mitochondrion is_a GO:0015816;GO:0170036;GO:1902475 WAS GO:0015816;GO:1902475;GO:1990542 biological_process GO:1905130 carcinine import across plasma membrane is_a GO:0015695;GO:0042886;GO:0045117;GO:0072337;GO:0098739 WAS GO:0015695;GO:0042886;GO:0045117;GO:0072337;GO:0098657;GO:0098739 biological_process GO:1905135 biotin import across plasma membrane is_a GO:0015878;GO:0035461;GO:0098739;GO:1905039 WAS GO:0015878;GO:0035461;GO:0098657;GO:0098739;GO:1905039 biological_process GO:1905136 dethiobiotin import across plasma membrane is_a GO:0015718;GO:0042886;GO:0098739;GO:1905039 WAS GO:0015718;GO:0042886;GO:0098657;GO:0098739;GO:1905039 biological_process GO:1905144 response to acetylcholine is_a GO:0010033;GO:1901698;GO:1901700 WAS GO:0010243;GO:1901700;GO:1902074 biological_process GO:1905145 cellular response to acetylcholine is_a GO:1901699;GO:1901701;GO:1905144 WAS GO:0071417;GO:1901701;GO:1902075;GO:1905144 biological_process GO:1905232 cellular response to L-glutamate is_a GO:0071230;GO:1902065 WAS GO:0071230;GO:1902065;GO:1902075 biological_process GO:1905242 response to 3,3',5-triiodo-L-thyronine is_a GO:0014070;GO:0043200 WAS GO:0014070;GO:0043200;GO:1902074 biological_process GO:1905243 cellular response to 3,3',5-triiodo-L-thyronine is_a GO:0071230;GO:0071407;GO:1905242 WAS GO:0071230;GO:0071407;GO:1902075;GO:1905242 biological_process GO:1905279 regulation of retrograde transport, endosome to Golgi is_a GO:0032386;GO:0060627 WAS GO:0060627;GO:1903649 biological_process GO:1905280 negative regulation of retrograde transport, endosome to Golgi is_a GO:0032387;GO:1905279 WAS GO:1903650;GO:1905279 biological_process GO:1905281 positive regulation of retrograde transport, endosome to Golgi is_a GO:0032388;GO:1905279 WAS GO:1903651;GO:1905279 biological_process GO:1905376 negative regulation of cytochrome-c oxidase activity is_a GO:0032413;GO:0051354;GO:1904063;GO:1904733;GO:1904959 WAS GO:0032413;GO:1904063;GO:1904733;GO:1904959 biological_process GO:1905439 response to chondroitin 6'-sulfate is_a GO:0010243;GO:1901700 WAS GO:0010243;GO:0034284 biological_process GO:1905440 cellular response to chondroitin 6'-sulfate is_a GO:0071417;GO:1901701;GO:1905439 WAS GO:0071326;GO:0071417;GO:1905439 biological_process GO:1905441 response to chondroitin 4'-sulfate is_a GO:0010243;GO:1901700 WAS GO:0010243;GO:0034284 biological_process GO:1905442 cellular response to chondroitin 4'-sulfate is_a GO:0071417;GO:1901701;GO:1905441 WAS GO:0071326;GO:0071417;GO:1905441 biological_process GO:1905794 response to puromycin is_a GO:0014074;GO:1901700 WAS GO:0014074;GO:1901700;GO:1902074 biological_process GO:1905795 cellular response to puromycin is_a GO:0071407;GO:0071417;GO:1901701;GO:1905794 WAS GO:0071407;GO:0071417;GO:1901701;GO:1902075;GO:1905794 biological_process GO:1905826 negative regulation of selenocysteine metabolic process is_a GO:0031324;GO:0045763;GO:0062014;GO:1905825 WAS GO:0045763;GO:1905825 biological_process GO:1905827 positive regulation of selenocysteine metabolic process is_a GO:0031325;GO:0045764;GO:0062013;GO:1905825 WAS GO:0045764;GO:1905825 biological_process GO:1990417 snoRNA release from pre-rRNA is_a GO:0006364 WAS GO:0006364;GO:0016074 biological_process GO:1990519 pyrimidine nucleotide import into mitochondrion is_a GO:0006864;GO:0072531;GO:0170036;GO:1901679 WAS GO:0006864;GO:0072531;GO:1901679;GO:1990542 biological_process GO:1990540 mitochondrial manganese ion transmembrane transport is_a GO:0071421;GO:1990542 WAS GO:0006839;GO:0071421 biological_process GO:1990543 mitochondrial S-adenosyl-L-methionine transmembrane transport is_a GO:1901962;GO:1990542 WAS GO:0006839;GO:1901962 biological_process GO:1990544 mitochondrial ATP transmembrane transport is_a GO:0015867;GO:0072530;GO:1901679;GO:1990542 WAS GO:0006839;GO:0015867;GO:0072530;GO:1901679 biological_process GO:1990545 mitochondrial thiamine pyrophosphate transmembrane transport is_a GO:0030974;GO:1990542 WAS GO:0006839;GO:0030974 biological_process GO:1990546 mitochondrial tricarboxylic acid transmembrane transport is_a GO:0035674;GO:1990542 WAS GO:0006839;GO:0035674 biological_process GO:1990547 mitochondrial phosphate ion transmembrane transport is_a GO:0035435;GO:1990542 WAS GO:0006839;GO:0035435 biological_process GO:1990548 mitochondrial FAD transmembrane transport is_a GO:0035350;GO:1990542 WAS GO:0006839;GO:0035350 biological_process GO:1990549 mitochondrial NAD transmembrane transport is_a GO:0035352;GO:1990542 WAS GO:0006839;GO:0035352 biological_process GO:1990550 mitochondrial alpha-ketoglutarate transmembrane transport is_a GO:0015742;GO:1905039;GO:1990542 WAS GO:0006839;GO:0015742;GO:1905039 biological_process GO:1990551 mitochondrial 2-oxoadipate transmembrane transport is_a GO:0006835;GO:1905039;GO:1990542 WAS GO:0006835;GO:0006839;GO:1905039 biological_process GO:1990553 mitochondrial 5'-adenylyl sulfate transmembrane transport is_a GO:1902558;GO:1990542 WAS GO:0006839;GO:1902558 biological_process GO:1990554 mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport is_a GO:1902559;GO:1990542 WAS GO:0006839;GO:1902559 biological_process GO:1990555 mitochondrial oxaloacetate transmembrane transport is_a GO:1902356;GO:1990542 WAS GO:0006839;GO:1902356 biological_process GO:1990556 mitochondrial isopropylmalate transmembrane transport is_a GO:1902357;GO:1990542 WAS GO:0006839;GO:1902357 biological_process GO:1990557 mitochondrial sulfate transmembrane transport is_a GO:1902358;GO:1990542 WAS GO:0006839;GO:1902358 biological_process GO:1990558 mitochondrial malonate(1-) transmembrane transport is_a GO:1901553;GO:1990542 WAS GO:0006839;GO:1901553 biological_process GO:1990559 mitochondrial coenzyme A transmembrane transport is_a GO:0035349;GO:1990542 WAS GO:0006839;GO:0035349 biological_process GO:1990575 mitochondrial L-ornithine transmembrane transport is_a GO:1903352;GO:1990542 WAS GO:0006839;GO:1903352 biological_process GO:1990616 magnesium ion export from mitochondrion is_a GO:0045016;GO:0170037 WAS GO:0045016 biological_process GO:1990818 L-arginine transmembrane export from vacuole is_a GO:0032974;GO:1902475 WAS GO:0032974;GO:0072337;GO:1902475 biological_process GO:1990983 regulation of translational initiation by tRNA modification is_a GO:0006400;GO:0006446 WAS GO:0006400;GO:0035513 biological_process GO:2000211 regulation of glutamate metabolic process is_a GO:0000820 WAS GO:0000820;GO:0034248 biological_process GO:2000212 negative regulation of glutamate metabolic process is_a GO:0031324;GO:0045763;GO:0062014;GO:2000211 WAS GO:0034249;GO:0045763;GO:2000211 biological_process GO:2000213 positive regulation of glutamate metabolic process is_a GO:0031325;GO:0045764;GO:0062013;GO:2000211 WAS GO:0034250;GO:0045764;GO:2000211 biological_process GO:2000215 negative regulation of proline metabolic process is_a GO:0031324;GO:0045763;GO:0062014;GO:2000214 WAS GO:0045763;GO:2000214 biological_process GO:2000216 positive regulation of proline metabolic process is_a GO:0031325;GO:0045764;GO:0062013;GO:2000214 WAS GO:0045764;GO:2000214 biological_process GO:2000282 regulation of cellular amino acid biosynthetic process is_a GO:0031326;GO:0051171;GO:0062012 WAS GO:0006521;GO:0031326 biological_process GO:2000283 negative regulation of amino acid biosynthetic process is_a GO:0031327;GO:0051172;GO:0062014;GO:2000282 WAS GO:0031327;GO:0045763;GO:2000282 biological_process GO:2000284 positive regulation of amino acid biosynthetic process is_a GO:0031328;GO:0051173;GO:0062013;GO:2000282 WAS GO:0031328;GO:0045764;GO:2000282 biological_process GO:2000890 cellodextrin catabolic process is_a GO:0009313;GO:1901027;GO:2000889 WAS GO:0009251;GO:0009313;GO:2000889 biological_process GO:2000901 cyclodextrin catabolic process is_a GO:0009313;GO:1901027;GO:2000900 WAS GO:0009251;GO:0009313;GO:2000900 biological_process GO:2001156 regulation of proline catabolic process to glutamate is_a GO:0031329;GO:0033241;GO:2000211;GO:2000214 WAS GO:0031329;GO:0033241;GO:0034251;GO:2000211;GO:2000214 biological_process GO:2001157 negative regulation of proline catabolic process to glutamate is_a GO:0031330;GO:0033242;GO:2000212;GO:2000215;GO:2001156 WAS GO:0031330;GO:0033242;GO:0034252;GO:2000212;GO:2000215;GO:2001156 biological_process GO:2001158 positive regulation of proline catabolic process to glutamate is_a GO:0031331;GO:0033243;GO:2000213;GO:2000216;GO:2001156 WAS GO:0031331;GO:0033243;GO:0034253;GO:2000213;GO:2000216;GO:2001156 biological_process GO:2001196 positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine is_a GO:0045764;GO:2000284;GO:2001194 WAS GO:2000284;GO:2001194 biological_process GO:2001276 regulation of leucine biosynthetic process is_a GO:0006521;GO:0031326 WAS GO:2000282 biological_process GO:2001277 negative regulation of leucine biosynthetic process is_a GO:0031327;GO:0045763;GO:0062014;GO:2001276 WAS GO:2000283;GO:2001276 biological_process GO:2001278 positive regulation of leucine biosynthetic process is_a GO:0031328;GO:0045764;GO:0062013;GO:2001276 WAS GO:2000284;GO:2001276 biological_process GO:2001296 N(omega)-methyl-L-arginine metabolic process is_a GO:0006575;GO:0170033;GO:0170041 WAS GO:0006575;GO:1901605 biological_process GO:2001297 N(omega)-methyl-L-arginine catabolic process is_a GO:0042219;GO:0170035;GO:0170044;GO:2001296 WAS GO:0009063;GO:0042219;GO:1901606;GO:2001296 biological_process GO:2001298 N(omega),N(omega)-dimethyl-L-arginine metabolic process is_a GO:0006575;GO:0170033;GO:0170041 WAS GO:0006575;GO:1901605 biological_process GO:2001299 N(omega),N(omega)-dimethyl-L-arginine catabolic process is_a GO:0042219;GO:0170035;GO:0170044;GO:2001298 WAS GO:0009063;GO:0042219;GO:1901606;GO:2001298 molecular_function GO:0000319 sulfite transmembrane transporter activity is_a GO:0015103;GO:1901682 WAS GO:0015103;GO:1901682;GO:1901702 molecular_function GO:0000514 3-sulfino-L-alanine is_a GO:0015078;GO:0015175;GO:0015179;GO:0072349;GO:0140848;GO:1901680 WAS GO:0015078;GO:0015175;GO:0015179;GO:0042887;GO:0072349;GO:0140848;GO:1901680;GO:1901702 molecular_function GO:0000515 aspartate:glutamate, proton antiporter activity is_a GO:0005310;GO:0015078;GO:0015556;GO:0140848 WAS GO:0005310;GO:0015078;GO:0015556;GO:0042887;GO:0140848;GO:1901702 molecular_function GO:0003712 transcription coregulator activity is_a GO:0030674;GO:0140110 WAS GO:0140110 molecular_function GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity is_a GO:0016937 WAS GO:0016289 molecular_function GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity is_a GO:0008172;GO:0008276 WAS GO:0008172 molecular_function GO:0004164 diphthine synthase activity is_a GO:0008276;GO:0008757 WAS GO:0008757 molecular_function GO:0004361 glutaryl-CoA dehydrogenase activity is_a GO:0016937 WAS GO:0003995 molecular_function GO:0004668 protein-arginine deiminase activity relationship N/A WAS part_of GO:0016570 molecular_function GO:0004791 thioredoxin-disulfide reductase (NADP) activity is_a GO:0016209;GO:0047134 WAS GO:0016209;GO:0016668 molecular_function GO:0004848 ureidoglycolate hydrolase activity is_a GO:0016811 WAS GO:0016813 molecular_function GO:0004970 glutamate-gated receptor activity is_a GO:0008066;GO:0015171;GO:0022824 WAS GO:0008066;GO:0015171;GO:0022824;GO:0042887;GO:1901702 molecular_function GO:0005078 MAP-kinase scaffold activity relationship has_part GO:0051019;part_of GO:0000165 WAS has_part GO:0051019;part_of GO:0043410 molecular_function GO:0005277 acetylcholine transmembrane transporter activity is_a GO:0005326;GO:0015101;GO:1901375 WAS GO:0005326;GO:0015651;GO:1901375;GO:1901702 molecular_function GO:0005302 L-tyrosine transmembrane transporter activity is_a GO:0015173;GO:0015179 WAS GO:0015173;GO:0015179;GO:1901702 molecular_function GO:0005313 L-glutamate transmembrane transporter activity is_a GO:0015172;GO:0015179 WAS GO:0015172;GO:0015179;GO:0042887;GO:1901702 molecular_function GO:0005347 ATP transmembrane transporter activity is_a GO:0000295;GO:0005346;GO:0008514 WAS GO:0000295;GO:0005346;GO:0008514;GO:1901702 molecular_function GO:0005372 water transmembrane transporter activity is_a GO:0015318 WAS GO:0015318;GO:1901702 molecular_function GO:0005385 zinc ion transmembrane transporter activity is_a GO:0046915 WAS GO:0046915;GO:1901702 molecular_function GO:0008199 ferric iron binding is_a GO:0005506 WAS GO:0005506;GO:1901681 molecular_function GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity is_a GO:0008169 WAS GO:0030580 relationship part_of GO:0006744 WAS N/A molecular_function GO:0008470 isovaleryl-CoA dehydrogenase activity is_a GO:0016937 WAS GO:0003995 molecular_function GO:0008659 (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity is_a GO:0019171 WAS GO:0016836 molecular_function GO:0009055 electron transfer activity is_a GO:0003674 WAS GO:0016491 relationship N/A WAS part_of GO:0022900 intersection_of N/A WAS is_a GO:0016491;part_of GO:0022900 molecular_function GO:0010348 lithium:proton antiporter activity is_a GO:0051139 WAS GO:0051139;GO:1901702 molecular_function GO:0010420 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity relationship part_of GO:0006744 WAS N/A molecular_function GO:0015079 potassium ion transmembrane transporter activity is_a GO:0046873 WAS GO:0046873;GO:1901702 molecular_function GO:0015081 sodium ion transmembrane transporter activity is_a GO:0046873 WAS GO:0046873;GO:1901702 molecular_function GO:0015085 calcium ion transmembrane transporter activity is_a GO:0046873 WAS GO:0046873;GO:1901702 molecular_function GO:0015091 ferric iron transmembrane transporter activity is_a GO:0005381 WAS GO:0005381;GO:1901682;GO:1901702 molecular_function GO:0015098 molybdate ion transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0015106 bicarbonate transmembrane transporter activity is_a GO:0008514 WAS GO:0008514;GO:0015318;GO:1901702 molecular_function GO:0015107 chlorate transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0015108 chloride transmembrane transporter activity is_a GO:0008509;GO:0015103 WAS GO:0008509;GO:0015103;GO:1901702 molecular_function GO:0015109 chromate transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0015112 nitrate transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0015115 silicate transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0015116 sulfate transmembrane transporter activity is_a GO:0015103;GO:1901682 WAS GO:0015103;GO:1901682;GO:1901702 molecular_function GO:0015123 acetate transmembrane transporter activity is_a GO:0008028 WAS GO:0008028;GO:1901702 molecular_function GO:0015129 lactate transmembrane transporter activity is_a GO:0008028;GO:1901618 WAS GO:0008028;GO:1901618;GO:1901702 molecular_function GO:0015130 mevalonate transmembrane transporter activity is_a GO:0022857 WAS GO:0008028;GO:1901618 molecular_function GO:0015137 citrate transmembrane transporter activity is_a GO:0015142 WAS GO:0015142;GO:1901702 molecular_function GO:0015138 fumarate transmembrane transporter activity is_a GO:0005310;GO:0015556 WAS GO:0005310;GO:0015556;GO:1901702 molecular_function GO:0015141 succinate transmembrane transporter activity is_a GO:0005310;GO:0015556 WAS GO:0005310;GO:0015556;GO:1901702 molecular_function GO:0015189 L-lysine transmembrane transporter activity is_a GO:0015174;GO:0015179 WAS GO:0015174;GO:0015179;GO:1901702 molecular_function GO:0015200 methylammonium transmembrane transporter activity is_a GO:0005275;GO:0015101 WAS GO:0005275;GO:0015101;GO:1901702 molecular_function GO:0015217 ADP transmembrane transporter activity is_a GO:0000295;GO:0005346;GO:0008514 WAS GO:0000295;GO:0005346;GO:0008514;GO:1901702 molecular_function GO:0015220 choline transmembrane transporter activity is_a GO:0015101 WAS GO:0015651;GO:1901702 molecular_function GO:0015229 L-ascorbic acid transmembrane transporter activity is_a GO:0015145;GO:0046943;GO:0090482 WAS GO:0015145;GO:0046943;GO:0090482;GO:1901702 molecular_function GO:0015350 methotrexate transmembrane transporter activity is_a GO:0005310;GO:0042887;GO:0042910 WAS GO:0005310;GO:0042887;GO:0042910;GO:0072349;GO:1901702 molecular_function GO:0015499 formate transmembrane transporter activity is_a GO:0008028 WAS GO:0008028;GO:1901702 molecular_function GO:0015501 glutamate:sodium symporter activity is_a GO:0005283 WAS GO:0005283;GO:0042887 molecular_function GO:0015552 propionate transmembrane transporter activity is_a GO:0015636 WAS GO:0015636;GO:1901702 molecular_function GO:0015654 tellurite transmembrane transporter activity is_a GO:0015103 WAS GO:0015103;GO:1901702 molecular_function GO:0016595 glutamate binding is_a GO:0016597 WAS GO:0016597;GO:0033218 molecular_function GO:0018064 protein-L-histidine N-tele-methyltransferase activity is_a GO:0008170;GO:0008276;GO:0008757 WAS GO:0008170;GO:0008757 molecular_function GO:0018814 phenylacetaldoxime dehydratase activity is_a GO:0141122 WAS GO:0016881 molecular_function GO:0019531 oxalate transmembrane transporter activity is_a GO:0005310 WAS GO:0005310;GO:1901702 molecular_function GO:0031458 ABC-type betaine transporter activity is_a GO:0015101;GO:0140359 WAS GO:0015418 molecular_function GO:0031925 pyridoxal transmembrane transporter activity is_a GO:0015101;GO:1901618 WAS GO:0015101;GO:1901618;GO:1901702 molecular_function GO:0031927 pyridoxamine transmembrane transporter activity is_a GO:0015101;GO:1901618 WAS GO:0015101;GO:1901618;GO:1901702 molecular_function GO:0031928 pyridoxine transmembrane transporter activity is_a GO:1901618 WAS GO:1901618;GO:1901702 molecular_function GO:0032217 riboflavin transmembrane transporter activity is_a GO:0008514;GO:0090482 WAS GO:0008514;GO:0090482;GO:1901702 molecular_function GO:0032500 muramyl dipeptide binding is_a GO:0033293;GO:0042277;GO:0097367 WAS GO:0042277;GO:0097367 molecular_function GO:0033266 ABC-type choline transporter activity is_a GO:0015220;GO:0140359 WAS GO:0015220;GO:0015418 molecular_function GO:0033913 glucan endo-1,2-beta-glucosidase activity is_a GO:0015926 WAS GO:0008422 molecular_function GO:0034013 aliphatic aldoxime dehydratase activity is_a GO:0141122 WAS GO:0016881 molecular_function GO:0034634 glutathione transmembrane transporter activity is_a GO:0008514;GO:0042937;GO:0072349;GO:1901682 WAS GO:0008514 molecular_function GO:0035276 ethanol binding is_a GO:0043168;GO:0043178 WAS GO:0043178 molecular_function GO:0042925 benzoate transmembrane transporter activity is_a GO:0042910;GO:0046943 WAS GO:0042910;GO:0046943;GO:1901702 molecular_function GO:0042958 maltodextrin transmembrane transporter activity is_a GO:0042957 WAS GO:0015159 molecular_function GO:0042973 glucan endo-1,3-beta-D-glucosidase activity is_a GO:0015926 WAS GO:0008422 molecular_function GO:0043295 glutathione binding is_a GO:0043168;GO:0072341;GO:1900750;GO:1901681 WAS GO:0043168 molecular_function GO:0043682 P-type divalent copper transporter activity is_a GO:0005375;GO:0015662;GO:0019829 WAS GO:0005375;GO:0015662;GO:0019829;GO:1901682;GO:1901702 molecular_function GO:0043759 2-methylbutanoate-CoA ligase activity is_a GO:0031955 WAS GO:0031956 molecular_function GO:0043872 lysine:cadaverine antiporter activity is_a GO:0015101;GO:0015171;GO:0015297 WAS GO:0015101;GO:0015171;GO:0015297;GO:1901702 molecular_function GO:0043879 glycolate transmembrane transporter activity is_a GO:0008028;GO:0015665 WAS GO:0008028;GO:0015665;GO:1901702 molecular_function GO:0044604 ABC-type phytochelatin transporter activity is_a GO:0008514;GO:0015440 WAS GO:0015440 molecular_function GO:0045301 tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity relationship N/A WAS part_of GO:0002195 molecular_function GO:0046557 glucan endo-1,6-beta-glucosidase activity is_a GO:0015926 WAS GO:0008422 molecular_function GO:0047720 indoleacetaldoxime dehydratase activity is_a GO:0141122 WAS GO:0016829 molecular_function GO:0047904 fructose 5-dehydrogenase activity is_a GO:0016901 WAS GO:0016614 molecular_function GO:0050218 propionate-CoA ligase activity is_a GO:0031955 WAS GO:0016405;GO:0016878 molecular_function GO:0050833 pyruvate transmembrane transporter activity is_a GO:0008028 WAS GO:0008028;GO:1901702 molecular_function GO:0051379 epinephrine binding is_a GO:0005488 WAS GO:1901338 molecular_function GO:0051870 methotrexate binding is_a GO:0031406;GO:0033218;GO:0097159;GO:1901363 WAS GO:0031406;GO:0033218;GO:0072341;GO:0097159;GO:1901363 molecular_function GO:0061459 L-arginine transmembrane transporter activity is_a GO:0015174;GO:0015179 WAS GO:0015174;GO:0015179;GO:0072349 molecular_function GO:0061542 3-demethylubiquinol-n 3-O-methyltransferase activity relationship part_of GO:0006744 WAS N/A molecular_function GO:0061797 pH-gated chloride channel activity is_a GO:0005254;GO:0160128 WAS GO:0005254;GO:0022836 molecular_function GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating is_a GO:0016799 WAS GO:0003953 relationship N/A WAS has_part GO:0061811;has_part GO:0061812 molecular_function GO:0070909 glutamate:gamma-aminobutyric acid antiporter activity is_a GO:0015185;GO:0015297;GO:0015355 WAS GO:0015185;GO:0015297;GO:0015355;GO:0042887;GO:1901702 molecular_function GO:0071164 RNA trimethylguanosine synthase activity is_a GO:0008173;GO:0008757 WAS GO:0008173 molecular_function GO:0090422 thiamine pyrophosphate transmembrane transporter activity is_a GO:0008514;GO:0015234;GO:0015605;GO:0015651 WAS GO:0008514;GO:0015234;GO:0015605;GO:0015651;GO:1901702 molecular_function GO:0097079 selenite:proton symporter activity is_a GO:0015295 WAS GO:0015295;GO:1901702 molecular_function GO:0097253 beta-hydroxybutyrate transmembrane transporter activity is_a GO:0015245;GO:0015665 WAS GO:0015245;GO:0015665;GO:1901702 molecular_function GO:0102025 ABC-type thiosulfate transporter activity is_a GO:0043225;GO:0140359;GO:1901682 WAS GO:0043225;GO:0140359;GO:1901682;GO:1901702 molecular_function GO:0106316 nitrite reductase NADH activity is_a GO:0098809 WAS GO:0008942 molecular_function GO:0140485 5-aminolevulinic acid transmembrane transporter activity is_a GO:0008028;GO:0015101;GO:0015171 WAS GO:0008028;GO:0015101;GO:0015171;GO:1901702 molecular_function GO:0140812 orotate:monoatomic anion antiporter activity is_a GO:0008509;GO:0015297;GO:0015355;GO:0022853 WAS GO:0008509;GO:0015297;GO:0015355;GO:0022853;GO:1901702 molecular_function GO:1901238 ABC-type tungstate transporter activity is_a GO:0043225;GO:0140359 WAS GO:0043225;GO:0140359;GO:1901702 molecular_function GO:1901239 malonate(1-) transmembrane transporter activity is_a GO:0005310 WAS GO:0005310;GO:1901702 molecular_function GO:1901974 glycerate transmembrane transporter activity is_a GO:0008028;GO:0015144;GO:0042879 WAS GO:0042879 molecular_function GO:1902485 L-cysteine binding is_a GO:0016597;GO:0043169;GO:1901681 WAS GO:0016597;GO:0043169;GO:0072341;GO:1901681 molecular_function GO:1903135 cupric ion binding is_a GO:0005507 WAS GO:0005507;GO:1901681 molecular_function GO:1903264 nitrate reductase activity involved in anaerobic electron transport chain is_a GO:0008940 WAS GO:0008940;GO:0009055 molecular_function GO:1903425 fluoride transmembrane transporter activity is_a GO:0008509;GO:0015103 WAS GO:0008509;GO:0015103;GO:1901702 molecular_function GO:2001080 chitosan binding is_a GO:0043169;GO:0097367 WAS GO:0097367 cellular_component GO:0005905 clathrin-coated pit is_a GO:0016020 WAS GO:0098590 cellular_component GO:0031533 mRNA capping enzyme complex is_a GO:0140513 WAS GO:0034708;GO:0140513 cellular_component GO:0033643 host cell part relationship N/A WAS part_of GO:0043657 intersection_of N/A WAS is_a GO:0018995;part_of GO:0043657 cellular_component GO:0045251 electron transfer flavoprotein complex is_a GO:0032991 WAS GO:1990204