CHANGES IN GO ONTOLOGY SUMMARY: CURRENT RELEASE release_date 2026-05-19 valid_terms 38263 obsolete_terms 10058 merged_terms 2434 biological_process_terms 24136 molecular_function_terms 10052 cellular_component_terms 4075 meta_statements 258977 cross_references 29549 terms_relations 74018 SUMMARY: PREVIOUS RELEASE release_date 2026-03-25 valid_terms 38560 obsolete_terms 9731 merged_terms 2434 biological_process_terms 24428 molecular_function_terms 10056 cellular_component_terms 4076 meta_statements 260935 cross_references 28690 terms_relations 74905 SUMMARY: DIFF BETWEEN RELEASES changes_created_terms 30 changes_valid_terms -297 changes_obsolete_terms 328 changes_merged_terms 0 changes_biological_process_terms -292 changes_molecular_function_terms -4 changes_cellular_component_terms -1 changes_meta_statements 198 changes_meta_statements_by_term 118 changes_cross_references 1304 changes_cross_references_by_term 260 changes_relations 600 changes_relations_by_term 586 DETAILED CHANGES 30 CREATED TERMS biological_process GO:0120576 1,2-dehydro-N-beta-alanyldopamine biosynthetic process biological_process GO:0120577 1,2-dehydro-N-acetyldopamine biosynthetic process biological_process GO:0140402 symbiont-mediated disassembly of host stress granules biological_process GO:0140411 symbiont-mediated suppression of host stress granule assembly biological_process GO:0140422 symbiont-mediated suppression of host immunothrombosis biological_process GO:0140424 symbiont-mediated activation of blood coagulation, intrinsic pathway biological_process GO:7770057 copper ion import into Golgi lumen biological_process GO:7770058 mitochondrial protein import pathway biological_process GO:7770059 alpha helical protein insertion into mitochondrial outer membrane biological_process GO:7770060 TOM-TIM23-SORT-mediated protein insertion into the mitochondrial inner membrane biological_process GO:7770061 TOM-TIM22-mediated mitochondrial inner membrane protein insertion biological_process GO:7770063 beta barrel protein insertion into mitochondrial outer membrane biological_process GO:7770069 ferritinophagy biological_process GO:7770071 venom-mediated activation of inflammatory response biological_process GO:7770074 protein O-linked glycosylation via N-acetylglucosamine biological_process GO:7770075 venom-mediated leukocyte infiltration biological_process GO:7770076 venom-mediated release of inflammatory mediator molecular_function GO:0140401 4-phosphoerythronate phosphatase activity molecular_function GO:0140427 crotonobetainyl-CoA hydratase activity molecular_function GO:0160321 vesicle docking activity molecular_function GO:7770062 vesicle membrane tethering activity molecular_function GO:7770064 actin-filament cross-linking activity molecular_function GO:7770065 peroxisome-chloroplast membrane tether activity molecular_function GO:7770066 endoplasmic reticulum-vacuole tether activity molecular_function GO:7770067 contractile vacuole-plasma membrane tether activity molecular_function GO:7770068 ferric iron reductase activity molecular_function GO:7770072 double-stranded RNA immune receptor activity molecular_function GO:7770073 left-handed Z-RNA immune receptor activity cellular_component GO:0140419 cytoplasmic lattice complex cellular_component GO:7770070 p24 cargo receptor complex 328 OBSOLETED TERMS CHANGES biological_process GO:0000052 citrulline metabolic process biological_process GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion biological_process GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway biological_process GO:0000948 amino acid catabolic process to carboxylic acid via Ehrlich pathway biological_process GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway biological_process GO:0000950 branched-chain amino acid catabolic process to alcohol via Ehrlich pathway biological_process GO:0000952 aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway biological_process GO:0000953 branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway biological_process GO:0000955 amino acid catabolic process via Ehrlich pathway biological_process GO:0003400 regulation of COPII vesicle coating biological_process GO:0006082 organic acid metabolic process biological_process GO:0006176 dATP biosynthetic process from ADP biological_process GO:0006187 dGTP biosynthetic process from dGDP biological_process GO:0006201 GMP catabolic process to IMP biological_process GO:0006202 GMP catabolic process to guanine biological_process GO:0006528 asparagine metabolic process biological_process GO:0006549 isoleucine metabolic process biological_process GO:0006558 L-phenylalanine metabolic process biological_process GO:0006568 L-tryptophan metabolic process biological_process GO:0006570 tyrosine metabolic process biological_process GO:0006573 valine metabolic process biological_process GO:0006587 serotonin biosynthetic process from L-tryptophan biological_process GO:0006782 protoporphyrinogen IX biosynthetic process biological_process GO:0006837 serotonin transport biological_process GO:0006903 vesicle targeting biological_process GO:0006904 vesicle docking involved in exocytosis biological_process GO:0007263 nitric oxide mediated signal transduction biological_process GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway biological_process GO:0009255 Entner-Doudoroff pathway through 6-phosphogluconate biological_process GO:0009442 allantoin assimilation pathway biological_process GO:0009448 GABA metabolic process biological_process GO:0009848 indoleacetic acid biosynthetic process via tryptophan biological_process GO:0009849 tryptophan-independent indoleacetic acid biosynthetic process biological_process GO:0010128 benzoate catabolic process via CoA ligation biological_process GO:0010134 sulfate assimilation via adenylyl sulfate reduction biological_process GO:0010144 pyridoxal phosphate biosynthetic process from pyridoxamine biological_process GO:0010381 peroxisome-chloroplast membrane tethering biological_process GO:0010514 induction of conjugation with cellular fusion biological_process GO:0010515 negative regulation of induction of conjugation with cellular fusion biological_process GO:0010749 regulation of nitric oxide mediated signal transduction biological_process GO:0010750 positive regulation of nitric oxide mediated signal transduction biological_process GO:0010751 negative regulation of nitric oxide mediated signal transduction biological_process GO:0010785 clathrin coating of Golgi vesicle, plasma membrane to endosome targeting biological_process GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion biological_process GO:0015695 organic cation transport biological_process GO:0015711 organic anion transport biological_process GO:0015844 monoamine transport biological_process GO:0015872 dopamine transport biological_process GO:0015874 norepinephrine transport biological_process GO:0016053 organic acid biosynthetic process biological_process GO:0016054 organic acid catabolic process biological_process GO:0016080 synaptic vesicle targeting biological_process GO:0016081 synaptic vesicle docking biological_process GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid biological_process GO:0018956 phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene biological_process GO:0018957 phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene biological_process GO:0019245 pyruvate fermentation to D(-)-lactate biological_process GO:0019246 pyruvate fermentation to L(+)-lactate biological_process GO:0019250 aerobic cobalamin biosynthetic process biological_process GO:0019251 anaerobic cobalamin biosynthetic process biological_process GO:0019285 glycine betaine biosynthetic process from choline biological_process GO:0019286 glycine betaine biosynthetic process from glycine biological_process GO:0019328 anaerobic gallate catabolic process biological_process GO:0019352 protoporphyrinogen IX biosynthetic process from glycine biological_process GO:0019353 protoporphyrinogen IX biosynthetic process from glutamate biological_process GO:0019360 nicotinamide nucleotide biosynthetic process from niacinamide biological_process GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) biological_process GO:0019393 glucarate biosynthetic process biological_process GO:0019397 gallate catabolic process via 2-pyrone-4,6-dicarboxylate biological_process GO:0019398 gallate catabolic process via gallate dioxygenase activity biological_process GO:0019415 acetate biosynthetic process from carbon monoxide biological_process GO:0019423 sulfur oxidation, ferric ion-dependent biological_process GO:0019482 beta-alanine metabolic process biological_process GO:0019488 ribitol catabolic process to D-xylulose 5-phosphate biological_process GO:0019512 lactose catabolic process via tagatose-6-phosphate biological_process GO:0019513 lactose catabolic process, using glucoside 3-dehydrogenase biological_process GO:0019515 lactose catabolic process via UDP-galactose biological_process GO:0019528 D-arabitol catabolic process to D-xylulose 5-phosphate biological_process GO:0019569 L-arabinose catabolic process to D-xylulose 5-phosphate biological_process GO:0019570 L-arabinose catabolic process to 2-oxoglutarate biological_process GO:0019573 D-arabinose catabolic process to D-xylulose 5-phosphate biological_process GO:0019584 galactonate catabolic process biological_process GO:0019589 anaerobic glycerol catabolic process to 1,3-propanediol and glycerone phosphate biological_process GO:0019590 L-arabitol catabolic process to D-xylulose 5-phosphate biological_process GO:0019597 (R)-mandelate catabolic process to benzoate biological_process GO:0019598 (R)-mandelate catabolic process to catechol biological_process GO:0019601 toluene oxidation via 2-hydroxytoluene biological_process GO:0019602 toluene oxidation via 3-hydroxytoluene biological_process GO:0019603 toluene oxidation via 4-hydroxytoluene biological_process GO:0019604 toluene oxidation to catechol biological_process GO:0019621 creatinine catabolic process to formate biological_process GO:0019623 atrazine catabolic process to urea biological_process GO:0019624 atrazine catabolic process to isopropylamine biological_process GO:0019625 atrazine catabolic process to cyanuric acid biological_process GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate biological_process GO:0019647 formaldehyde assimilation via ribulose monophosphate cycle biological_process GO:0019648 formaldehyde assimilation via xylulose monophosphate cycle biological_process GO:0019651 citrate fermentation to diacetyl biological_process GO:0019672 acetyl-CoA fermentation to butyrate biological_process GO:0019687 pyruvate biosynthetic process from acetate biological_process GO:0019696 toluene oxidation via toluene-cis-1,2-dihydrodiol biological_process GO:0031388 organic acid phosphorylation biological_process GO:0032005 signal transduction involved in positive regulation of conjugation with cellular fusion biological_process GO:0032917 polyamine acetylation biological_process GO:0032918 spermidine acetylation biological_process GO:0032919 spermine acetylation biological_process GO:0032920 putrescine acetylation biological_process GO:0033311 chlorophyll a biosynthetic process via phytyl diphosphate biological_process GO:0033312 chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a biological_process GO:0033323 choline biosynthetic process via CDP-choline biological_process GO:0033324 choline biosynthetic process via N-monomethylethanolamine biological_process GO:0033325 choline biosynthetic process via phosphoryl-ethanolamine biological_process GO:0033387 putrescine biosynthetic process from arginine, via ornithine biological_process GO:0033388 putrescine biosynthetic process from arginine biological_process GO:0033389 putrescine biosynthetic process from arginine, via agmatine biological_process GO:0033390 putrescine biosynthetic process from arginine via N-carbamoylputrescine biological_process GO:0033393 homogalacturonan catabolic process biological_process GO:0033476 indoleacetic acid ester conjugate biosynthetic process biological_process GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol biological_process GO:0033489 cholesterol biosynthetic process via desmosterol biological_process GO:0033490 cholesterol biosynthetic process via lathosterol biological_process GO:0033506 glucosinolate biosynthetic process from homomethionine biological_process GO:0033507 glucosinolate biosynthetic process from phenylalanine biological_process GO:0033526 tetrapyrrole biosynthetic process from glutamate biological_process GO:0033527 tetrapyrrole biosynthetic process from glycine and succinyl-CoA biological_process GO:0033537 ajugose biosynthetic process using galactinol:raffinose galactosyltransferase biological_process GO:0033538 ajugose biosynthetic process using galactan:galactan galactosyltransferase biological_process GO:0033541 fatty acid beta-oxidation, unsaturated, odd number biological_process GO:0033542 fatty acid beta-oxidation, unsaturated, even number biological_process GO:0033543 fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway biological_process GO:0033544 fatty acid beta-oxidation, unsaturated, even number, epimerase pathway biological_process GO:0033545 myo-inositol hexakisphosphate biosynthetic process, lipid-dependent biological_process GO:0033546 myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate biological_process GO:0033548 myo-inositol hexakisphosphate biosynthetic process, lipid-independent biological_process GO:0036008 sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate biological_process GO:0036506 maintenance of unfolded protein biological_process GO:0042195 aerobic gallate catabolic process biological_process GO:0042210 octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol biological_process GO:0043438 acetoacetic acid metabolic process biological_process GO:0043441 acetoacetic acid biosynthetic process biological_process GO:0043442 acetoacetic acid catabolic process biological_process GO:0043640 benzoate catabolic process via hydroxylation biological_process GO:0044579 butyryl-CoA biosynthetic process from acetyl-CoA biological_process GO:0044581 butyryl-CoA catabolic process to butyrate biological_process GO:0044582 butyryl-CoA catabolic process to butanol biological_process GO:0045479 vesicle targeting to fusome biological_process GO:0046180 ketogluconate biosynthetic process biological_process GO:0046181 ketogluconate catabolic process biological_process GO:0046327 glycerol biosynthetic process from pyruvate biological_process GO:0046482 para-aminobenzoic acid metabolic process biological_process GO:0046501 protoporphyrinogen IX metabolic process biological_process GO:0048199 vesicle targeting, to, from or within Golgi biological_process GO:0048201 vesicle targeting, plasma membrane to endosome biological_process GO:0048203 vesicle targeting, trans-Golgi to endosome biological_process GO:0048204 vesicle targeting, inter-Golgi cisterna biological_process GO:0048206 vesicle targeting, cis-Golgi to rough endoplasmic reticulum biological_process GO:0048207 vesicle targeting, rough ER to cis-Golgi biological_process GO:0048209 regulation of vesicle targeting, to, from or within Golgi biological_process GO:0048211 Golgi vesicle docking biological_process GO:0048241 epinephrine transport biological_process GO:0048278 vesicle docking biological_process GO:0051483 terpenoid biosynthetic process, mevalonate-independent biological_process GO:0051485 terpenoid biosynthetic process, mevalonate-dependent biological_process GO:0051519 activation of bipolar cell growth biological_process GO:0051937 catecholamine transport biological_process GO:0052698 ergothioneine metabolic process biological_process GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide biological_process GO:0052786 alpha-linked polysaccharide catabolism to maltotriose biological_process GO:0052787 alpha-linked polysaccharide catabolism to maltopentaose biological_process GO:0052889 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene biological_process GO:0060986 endocrine hormone secretion biological_process GO:0061610 glycerol catabolic process to glycerone phosphate biological_process GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate biological_process GO:0061679 Entner-Doudoroff pathway through gluconate biological_process GO:0061680 Entner-Doudoroff pathway through gluconate to D-glyceraldehyde biological_process GO:0061681 Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate biological_process GO:0061688 glycolytic process via Entner-Doudoroff Pathway biological_process GO:0061705 sucrose catabolic process to fructose-6-phosphate through glucose and fructose biological_process GO:0061719 glucose catabolic process to pyruvate utilizing ADP biological_process GO:0061720 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde biological_process GO:0061721 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-) biological_process GO:0061728 GDP-mannose biosynthetic process from mannose biological_process GO:0061729 GDP-D-mannose biosynthetic process from fructose-6-phosphate biological_process GO:0061790 dense core granule docking biological_process GO:0061817 endoplasmic reticulum-plasma membrane tethering biological_process GO:0062095 endoplasmic reticulum-peroxisome tethering biological_process GO:0070189 kynurenine metabolic process biological_process GO:0070220 aerobic sulfur oxidation biological_process GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase biological_process GO:0070222 sulfide oxidation, using sulfide dehydrogenase biological_process GO:0070223 sulfide oxidation, using sulfur dioxygenase biological_process GO:0070275 aerobic ammonia oxidation to nitrite via pyruvic oxime biological_process GO:0070680 asparaginyl-tRNAAsn biosynthesis via transamidation biological_process GO:0070832 phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline biological_process GO:0070833 phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine biological_process GO:0070834 phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine biological_process GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion biological_process GO:0090384 phagosome-lysosome docking biological_process GO:0090522 vesicle tethering involved in exocytosis biological_process GO:0090531 L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose biological_process GO:0090532 L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate biological_process GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway biological_process GO:0090638 phosphatidylcholine biosynthesis from phosphatidylethanolamine biological_process GO:0090639 phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol biological_process GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine biological_process GO:0097053 L-kynurenine catabolic process biological_process GO:0097711 ciliary basal body-plasma membrane docking biological_process GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane biological_process GO:0099022 vesicle tethering biological_process GO:0099041 vesicle tethering to Golgi biological_process GO:0099044 vesicle tethering to endoplasmic reticulum biological_process GO:0099069 synaptic vesicle tethering involved in synaptic vesicle exocytosis biological_process GO:0099148 regulation of synaptic vesicle docking biological_process GO:0106020 regulation of vesicle docking biological_process GO:0106021 negative regulation of vesicle docking biological_process GO:0106022 positive regulation of vesicle docking biological_process GO:0106047 polyamine deacetylation biological_process GO:0106048 spermidine deacetylation biological_process GO:0140025 contractile vacuole tethering involved in discharge biological_process GO:0140057 vacuole-mitochondria membrane tethering biological_process GO:0140479 ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase biological_process GO:0160249 glycogen biosynthetic process via UDP-glucose biological_process GO:0160250 glycogen biosynthetic process via ADP-glucose biological_process GO:0160251 glycogen catabolic process via dextrin biological_process GO:0160252 glycogen catabolic process via dextrin and maltose biological_process GO:1900237 positive regulation of induction of conjugation with cellular fusion biological_process GO:1900318 regulation of methane biosynthetic process from dimethylamine biological_process GO:1900319 negative regulation of methane biosynthetic process from dimethylamine biological_process GO:1900320 positive regulation of methane biosynthetic process from dimethylamine biological_process GO:1900330 regulation of methane biosynthetic process from trimethylamine biological_process GO:1900331 negative regulation of methane biosynthetic process from trimethylamine biological_process GO:1900332 positive regulation of methane biosynthetic process from trimethylamine biological_process GO:1900333 regulation of methane biosynthetic process from 3-(methylthio)propionic acid biological_process GO:1900334 negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid biological_process GO:1900335 positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid biological_process GO:1900336 regulation of methane biosynthetic process from carbon monoxide biological_process GO:1900337 negative regulation of methane biosynthetic process from carbon monoxide biological_process GO:1900338 positive regulation of methane biosynthetic process from carbon monoxide biological_process GO:1900339 regulation of methane biosynthetic process from formic acid biological_process GO:1900340 negative regulation of methane biosynthetic process from formic acid biological_process GO:1900341 positive regulation of methane biosynthetic process from formic acid biological_process GO:1900342 regulation of methane biosynthetic process from dimethyl sulfide biological_process GO:1900343 negative regulation of methane biosynthetic process from dimethyl sulfide biological_process GO:1900344 positive regulation of methane biosynthetic process from dimethyl sulfide biological_process GO:1900345 regulation of methane biosynthetic process from methanethiol biological_process GO:1900346 negative regulation of methane biosynthetic process from methanethiol biological_process GO:1900347 positive regulation of methane biosynthetic process from methanethiol biological_process GO:1900348 regulation of methane biosynthetic process from methylamine biological_process GO:1900349 negative regulation of methane biosynthetic process from methylamine biological_process GO:1900350 positive regulation of methane biosynthetic process from methylamine biological_process GO:1900494 regulation of butyryl-CoA biosynthetic process from acetyl-CoA biological_process GO:1900495 negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA biological_process GO:1900496 positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA biological_process GO:1900497 regulation of butyryl-CoA catabolic process to butanol biological_process GO:1900498 negative regulation of butyryl-CoA catabolic process to butanol biological_process GO:1900499 positive regulation of butyryl-CoA catabolic process to butanol biological_process GO:1900500 regulation of butyryl-CoA catabolic process to butyrate biological_process GO:1900501 negative regulation of butyryl-CoA catabolic process to butyrate biological_process GO:1900502 positive regulation of butyryl-CoA catabolic process to butyrate biological_process GO:1901056 trimethylenediamine catabolic process biological_process GO:1901157 neomycin catabolic process biological_process GO:1901410 regulation of tetrapyrrole biosynthetic process from glutamate biological_process GO:1901411 negative regulation of tetrapyrrole biosynthetic process from glutamate biological_process GO:1901412 positive regulation of tetrapyrrole biosynthetic process from glutamate biological_process GO:1901413 regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA biological_process GO:1901414 negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA biological_process GO:1901415 positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA biological_process GO:1901605 alpha-amino acid metabolic process biological_process GO:1901606 alpha-amino acid catabolic process biological_process GO:1901607 alpha-amino acid biosynthetic process biological_process GO:1901791 3-(2,3-dihydroxyphenyl)propanoate catabolic process biological_process GO:1901803 1,5-anhydro-D-fructose biosynthetic process biological_process GO:1901814 astaxanthin catabolic process biological_process GO:1901823 delta-carotene catabolic process biological_process GO:1901829 zeaxanthin bis(beta-D-glucoside) catabolic process biological_process GO:1901832 all-trans-neoxanthin catabolic process biological_process GO:1901996 regulation of indoleacetic acid biosynthetic process via tryptophan biological_process GO:1902224 ketone body metabolic process biological_process GO:1902768 isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate biological_process GO:1902924 poly(hydroxyalkanoate) biosynthetic process from glucose biological_process GO:1902925 poly(hydroxyalkanoate) biosynthetic process from fatty acid biological_process GO:1903184 L-dopa metabolic process biological_process GO:1903185 L-dopa biosynthetic process biological_process GO:1903195 regulation of L-dopa biosynthetic process biological_process GO:1903196 negative regulation of L-dopa biosynthetic process biological_process GO:1903197 positive regulation of L-dopa biosynthetic process biological_process GO:1903314 regulation of nitrogen cycle metabolic process biological_process GO:1903315 negative regulation of nitrogen cycle metabolic process biological_process GO:1903316 positive regulation of nitrogen cycle metabolic process biological_process GO:1904122 positive regulation of fatty acid beta-oxidation by octopamine signaling pathway biological_process GO:1904123 positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway biological_process GO:1904538 regulation of glycolytic process through fructose-6-phosphate biological_process GO:1904735 regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process GO:1904736 negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process GO:1904737 positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process GO:1905353 ciliary transition fiber assembly biological_process GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering biological_process GO:1990489 anaerobic pectin catabolic process biological_process GO:1990491 methane biosynthetic process from methanol and hydrogen biological_process GO:1990854 vacuole-ER tethering biological_process GO:2001127 methane biosynthetic process from formic acid biological_process GO:2001128 methane biosynthetic process from methylamine biological_process GO:2001129 methane biosynthetic process from dimethylamine biological_process GO:2001130 methane biosynthetic process from trimethylamine biological_process GO:2001131 methane biosynthetic process from dimethyl sulfide biological_process GO:2001132 methane biosynthetic process from 3-(methylthio)propionic acid biological_process GO:2001133 methane biosynthetic process from methanethiol biological_process GO:2001134 methane biosynthetic process from carbon monoxide biological_process GO:7770032 tyramine transport cellular_component GO:0005870 actin capping protein of dynactin complex cellular_component GO:0035842 old cell tip after activation of bipolar cell growth cellular_component GO:1990727 tubulin folding cofactor complex molecular_function GO:0008374 O-acyltransferase activity molecular_function GO:0008411 4-hydroxybutyrate CoA-transferase activity molecular_function GO:0008785 alkyl hydroperoxide reductase activity molecular_function GO:0008875 gluconate dehydrogenase activity molecular_function GO:0016408 C-acyltransferase activity molecular_function GO:0016410 N-acyltransferase activity molecular_function GO:0016417 S-acyltransferase activity molecular_function GO:0018581 hydroxyquinol 1,2-dioxygenase activity molecular_function GO:0031249 denatured protein binding molecular_function GO:0043713 (R)-2-hydroxyisocaproate dehydrogenase activity molecular_function GO:0045550 geranylgeranyl reductase activity molecular_function GO:0046715 active borate transmembrane transporter activity molecular_function GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity molecular_function GO:0047468 phosphoglucomutase (glucose-cofactor) activity molecular_function GO:0051082 unfolded protein binding molecular_function GO:7770028 glycoprotein cargo receptor activity 0 MERGED TERMS CHANGES 118 META CHANGES cellular_component GO:0000145 exocyst definition "A vesicle tethering complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152] WAS "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152] cellular_component GO:0005576 extracellular region comment Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897. WAS Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. cellular_component GO:0017109 glutamate-cysteine ligase complex definition "An enzyme complex that catalyzes the ligation of L-glutamate to L-cysteine, forming gamma-L-glutamyl-L-cysteine." [PMID:9675072] WAS "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [PMID:9675072] cellular_component GO:0061852 retrograde cargo receptor complex, Golgi to ER name retrograde cargo receptor complex, Golgi to ER WAS retrograde transporter complex, Golgi to ER definition "Cargo receptor complex that recognizes, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles." [GOC:bhm, PMID:16093310] WAS "Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles." [GOC:bhm, PMID:16093310] synonyms "ERV41-ERV46 retrograde receptor complex" NARROW [];"retrograde cargo receptor complex, Golgi to endoplasmic reticulum" EXACT [];"retrograde receptor complex, Golgi to endoplasmic reticulum" EXACT [];"retrograde receptor complex, Golgi to ER" EXACT [];"retrograde transporter complex, Golgi to ER" BROAD [] WAS "ERV41-ERV46 retrograde receptor complex" NARROW [];"retrograde receptor complex, Golgi to endoplasmic reticulum" EXACT [];"retrograde receptor complex, Golgi to ER" EXACT [];"retrograde transporter complex, Golgi to endoplasmic reticulum" EXACT [] cellular_component GO:1990334 SIN/MEN two-component GAP complex name SIN/MEN two-component GAP complex WAS Bfa1-Bub2 complex definition "A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation." [GOC:bhm, PMID:16449187] WAS "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, PMID:16449187] synonyms "Bfa1-Bub2 complex" NARROW [];"Byr4-Cdc16 GAP complex" NARROW [] WAS N/A cellular_component GO:1990819 mating projection actin fusion focus definition "A focus at the mating projection tip where the cell wall is degraded during cytogamy. Actin filaments form an aster-like structure from this location." [PMID:25825517] WAS "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517] biological_process GO:0000256 allantoin catabolic process definition "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [PMID:41016821] WAS "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] synonyms "allantoin assimilation" EXACT [];"allantoin breakdown" EXACT [];"allantoin catabolism" EXACT [];"allantoin degradation" EXACT [] WAS "allantoin breakdown" EXACT [];"allantoin catabolism" EXACT [];"allantoin degradation" EXACT [] biological_process GO:0002143 tRNA wobble position uridine thiolation definition "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps." [PMID:16871210] WAS "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] biological_process GO:0006041 D-glucosamine metabolic process name D-glucosamine metabolic process WAS glucosamine metabolic process synonyms "chitosamine metabolic process" EXACT [];"chitosamine metabolism" EXACT [];"glucosamine metabolic process" EXACT [];"glucosamine metabolism" EXACT [] WAS "chitosamine metabolic process" EXACT [];"chitosamine metabolism" EXACT [];"glucosamine metabolism" EXACT [] biological_process GO:0006042 D-glucosamine biosynthetic process name D-glucosamine biosynthetic process WAS glucosamine biosynthetic process synonyms "chitosamine biosynthesis" EXACT [];"chitosamine biosynthetic process" EXACT [];"glucosamine anabolism" EXACT [];"glucosamine biosynthesis" EXACT [];"glucosamine biosynthetic process" EXACT [];"glucosamine formation" EXACT [];"glucosamine synthesis" EXACT [] WAS "chitosamine biosynthesis" EXACT [];"chitosamine biosynthetic process" EXACT [];"glucosamine anabolism" EXACT [];"glucosamine biosynthesis" EXACT [];"glucosamine formation" EXACT [];"glucosamine synthesis" EXACT [] biological_process GO:0006043 D-glucosamine catabolic process name D-glucosamine catabolic process WAS glucosamine catabolic process synonyms "chitosamine catabolic process" EXACT [];"chitosamine catabolism" EXACT [];"glucosamine breakdown" EXACT [];"glucosamine catabolic process" EXACT [];"glucosamine catabolism" EXACT [];"glucosamine degradation" EXACT [] WAS "chitosamine catabolic process" EXACT [];"chitosamine catabolism" EXACT [];"glucosamine breakdown" EXACT [];"glucosamine catabolism" EXACT [];"glucosamine degradation" EXACT [] biological_process GO:0006423 cysteinyl-tRNA aminoacylation definition "The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] WAS "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] biological_process GO:0006550 L-isoleucine catabolic process synonyms "isoleucine breakdown" EXACT [];"isoleucine catabolism" EXACT [];"isoleucine degradation" EXACT [];"L-isoleucine catabolic process via Ehrlich pathway" NARROW [];"L-isoleucine degradation via Ehrlich pathway" NARROW [] WAS "isoleucine breakdown" EXACT [];"isoleucine catabolism" EXACT [];"isoleucine degradation" EXACT [] biological_process GO:0006552 L-leucine catabolic process synonyms "L-leucine breakdown" EXACT [];"L-leucine catabolism" EXACT [];"L-leucine degradation" EXACT [];"L-leucine degradation via Ehrlich pathway" NARROW [];"L-methionine catabolic process via Ehrlich pathway" NARROW [];"leucine catabolic process" BROAD [] WAS "L-leucine breakdown" EXACT [];"L-leucine catabolism" EXACT [];"L-leucine degradation" EXACT [];"leucine catabolic process" BROAD [] biological_process GO:0006559 L-phenylalanine catabolic process synonyms "L-phenylalanine breakdown" EXACT [];"L-phenylalanine catabolic process via Ehrlich pathway" NARROW [];"L-phenylalanine catabolism" EXACT [];"L-phenylalanine degradation" EXACT [];"L-phenylalanine degradation via Ehrlich pathway" NARROW [];"phenylalanine catabolic process" BROAD [];"phenylalanine catabolism" BROAD [] WAS "L-phenylalanine breakdown" EXACT [];"L-phenylalanine catabolism" EXACT [];"L-phenylalanine degradation" EXACT [];"phenylalanine catabolic process" BROAD [];"phenylalanine catabolism" BROAD [] biological_process GO:0006569 L-tryptophan catabolic process synonyms "L-tryptophan catabolic process via Ehrlich pathway" NARROW [];"L-tryptophan degradation via Ehrlich pathway" NARROW [];"tryptophan breakdown" EXACT [];"tryptophan catabolic process" RELATED [];"tryptophan catabolic process, using tryptophanase" NARROW [];"tryptophan catabolism" EXACT [];"tryptophan catabolism, using tryptophanase" NARROW [];"tryptophan degradation" EXACT [] WAS "tryptophan breakdown" EXACT [];"tryptophan catabolic process" RELATED [];"tryptophan catabolic process, using tryptophanase" NARROW [];"tryptophan catabolism" EXACT [];"tryptophan catabolism, using tryptophanase" NARROW [];"tryptophan degradation" EXACT [] biological_process GO:0006574 L-valine catabolic process synonyms "valine breakdown" EXACT [];"valine catabolism" EXACT [];"valine degradation" EXACT [];"valine degradation via Ehrlich pathway" NARROW [] WAS "valine breakdown" EXACT [];"valine catabolism" EXACT [];"valine degradation" EXACT [] biological_process GO:0006583 melanin biosynthetic process from tyrosine definition "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] WAS "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:curators] biological_process GO:0006592 L-ornithine biosynthetic process name L-ornithine biosynthetic process WAS ornithine biosynthetic process synonyms "ornithine anabolism" EXACT [];"ornithine biosynthesis" EXACT [];"ornithine biosynthetic process" BROAD [];"ornithine formation" EXACT [];"ornithine synthesis" EXACT [] WAS "ornithine anabolism" EXACT [];"ornithine biosynthesis" EXACT [];"ornithine formation" EXACT [];"ornithine synthesis" EXACT [] biological_process GO:0006598 polyamine catabolic process synonyms "polyamine back-conversion" RELATED [];"polyamine breakdown" EXACT [];"polyamine catabolism" EXACT [];"polyamine degradation" EXACT [];"polyamine interconversion" RELATED [] WAS "polyamine breakdown" EXACT [];"polyamine catabolism" EXACT [];"polyamine degradation" EXACT [] biological_process GO:0006727 ommochrome biosynthetic process synonyms "kynurenine pathway" BROAD [];"ommochrome anabolism" EXACT [];"ommochrome biosynthesis" EXACT [];"ommochrome formation" EXACT [];"ommochrome synthesis" EXACT [] WAS "ommochrome anabolism" EXACT [];"ommochrome biosynthesis" EXACT [];"ommochrome formation" EXACT [];"ommochrome synthesis" EXACT [] biological_process GO:0006901 vesicle coat assembly name vesicle coat assembly WAS vesicle coating synonyms "vesicle coating" EXACT [] WAS "vesicle coat assembly" BROAD [] biological_process GO:0008153 4-aminobenzoate biosynthetic process definition "The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] WAS "The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] biological_process GO:0008354 primordial germ cell migration name primordial germ cell migration WAS germ cell migration synonyms "embryonic germ cell migration" EXACT [];"germ cell migration" BROAD [];"germ-cell migration" BROAD [];"pole cell migration" NARROW [] WAS "germ-cell migration" EXACT [];"pole cell migration" NARROW [];"primordial germ cell migration" RELATED [] biological_process GO:0009067 aspartate family amino acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of L-aspartate or any of the amino acids synthesised from it (L-asparagine, L-lysine, L-methionine, L-threonine and L-isoleucine)." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] biological_process GO:0009070 serine family amino acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of an amino acid derived from 3-phosphoglycerate (L-serine, glycine, L-cysteine and L-homocysteine)." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] biological_process GO:0009073 aromatic amino acid biosynthetic process name aromatic amino acid biosynthetic process WAS aromatic amino acid family biosynthetic process definition "The chemical reactions and pathways resulting in the formation of an amino acid whose structure includes an aromatic ring." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:curators] biological_process GO:0009074 aromatic amino acid catabolic process name aromatic amino acid catabolic process WAS aromatic amino acid family catabolic process definition "The chemical reactions and pathways resulting in the breakdown of an amino acid whose structure includes an aromatic ring." [GOC:curators] WAS "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:curators] biological_process GO:0009079 pyruvate family amino acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of an L-amino acid derived from pyruvate (L-alanine, L-valine, and L-leucine)." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] biological_process GO:0009084 glutamate family amino acid biosynthetic process name glutamate family amino acid biosynthetic process WAS L-glutamine family amino acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of L-glutamate or any of the amino acids synthesised from it (L-glutamine, L-proline and L-arginine)." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] biological_process GO:0009087 L-methionine catabolic process synonyms "L-methionine catabolic process via Ehrlich pathway" NARROW [];"L-methionine degradation via Ehrlich pathway" NARROW [];"methionine breakdown" EXACT [];"methionine catabolism" EXACT [];"methionine degradation" EXACT [] WAS "methionine breakdown" EXACT [];"methionine catabolism" EXACT [];"methionine degradation" EXACT [] biological_process GO:0009298 GDP-mannose biosynthetic process definition "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [MetaCyc:PWY-5659] WAS "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] biological_process GO:0009684 indoleacetic acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [PMID:12620340] WAS "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] biological_process GO:0016266 protein O-linked glycosylation via N-acetylgalactosamine name protein O-linked glycosylation via N-acetylgalactosamine WAS protein O-linked glycosylation via N-acetyl-galactosamine synonyms "core O-glycan biosynthetic process" EXACT [];"mucin-type O-glycan synthesis" NARROW [];"O-glycan processing" EXACT [];"protein O-linked GalNAcylation" RELATED [];"protein O-linked glycosylation via N-acetyl-galactosamine" EXACT [] WAS "core O-glycan biosynthetic process" EXACT [];"mucin-type O-glycan synthesis" NARROW [];"O-glycan processing" EXACT [];"protein O-linked GalNAcylation" RELATED [] biological_process GO:0019240 L-citrulline biosynthetic process name L-citrulline biosynthetic process WAS citrulline biosynthetic process definition "The chemical reactions and pathways resulting in the formation of L-citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] WAS "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonyms "citrulline anabolism" EXACT [];"citrulline biosynthesis" EXACT [];"citrulline biosynthetic process" BROAD [];"citrulline formation" EXACT [];"citrulline synthesis" EXACT [] WAS "citrulline anabolism" EXACT [];"citrulline biosynthesis" EXACT [];"citrulline formation" EXACT [];"citrulline synthesis" EXACT [] biological_process GO:0019244 pyruvate fermentation to lactate definition "The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into D-lactate or L-lactate." [GOC:curators] WAS "The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into lactate." [GOC:curators] biological_process GO:0019254 carnitine metabolic process, CoA-linked definition "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] WAS "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:curators] biological_process GO:0019418 sulfide oxidation definition "The chemical reactions and pathways resulting in the conversion of sufide to sulfite or sulfate." [MetaCyc:Sulfide-Oxidation] WAS "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:Sulfide-Oxidation] synonyms "hydrogen sulfide catabolic process" EXACT [];"sulphide oxidation" EXACT [] WAS "sulphide oxidation" EXACT [] biological_process GO:0019596 (R)-mandelate catabolic process name (R)-mandelate catabolic process WAS mandelate catabolic process definition "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate, the anion of (R)-mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:curators] WAS "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:curators] synonyms "mandelate breakdown" EXACT [];"mandelate catabolic process" BROAD [];"mandelate catabolism" EXACT [];"mandelate degradation" EXACT [] WAS "mandelate breakdown" EXACT [];"mandelate catabolism" EXACT [];"mandelate degradation" EXACT [] biological_process GO:0030150 protein import into mitochondrial matrix definition "The import of proteins with mitochondrial targeting sequence from the cytosol across the mitochondrial outer and inner membranes into the matrix via TOM-TIM23-PAM." [ISBN:0716731363, PMID:36931257] WAS "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonyms "mitochondrial matrix protein import" EXACT [];"mitochondrial translocation" BROAD [];"protein transport into mitochondrial matrix" EXACT [];"TOM-TIM23-PAM presequence matrix import pathway" EXACT [] WAS "mitochondrial matrix protein import" EXACT [];"mitochondrial translocation" BROAD [];"protein transport into mitochondrial matrix" EXACT [] biological_process GO:0030645 acetyl-CoA fermentation to butanoate definition "The anaerobic chemical reactions and pathways resulting in the breakdown of acetyl-CoA to butyrate, yielding energy in the form of ATP. Butanoate is secreted by the cell." [MetaCyc:PWY-5676] WAS "The anaerobic chemical reactions and pathways resulting in the production of acetic acid, butyric acid, and dihydrogen from acetyl-CoA; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732, Metacyc:PWY-5676] biological_process GO:0033228 L-cysteine export across plasma membrane name L-cysteine export across plasma membrane WAS cysteine export across plasma membrane definition "The directed movement of L-cysteine from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mlg] WAS "The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mlg] synonyms "cysteine export" BROAD [];"cysteine export across plasma membrane" BROAD [];"L-cysteine export" BROAD [] WAS "cysteine export" BROAD [] biological_process GO:0033499 beta-D-galactose catabolic process via UDP-galactose, Leloir pathway name beta-D-galactose catabolic process via UDP-galactose, Leloir pathway WAS galactose catabolic process via UDP-galactose, Leloir pathway definition "The chemical reactions and pathways resulting in the breakdown of beta-D-galactose, via the intermediate UDP-galactose." [MetaCyc:PWY-6317] WAS "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah] synonyms "galactose breakdown via UDP-galactose" EXACT [];"galactose catabolic process via UDP-galactose, Leloir pathway" NARROW [];"galactose catabolism via UDP-galactose" EXACT [];"galactose degradation via UDP-galactose" EXACT [];"Leloir Pathway" EXACT [PMID:14741191] WAS "galactose breakdown via UDP-galactose" EXACT [];"galactose catabolism via UDP-galactose" EXACT [];"galactose degradation via UDP-galactose" EXACT [];"Leloir Pathway" EXACT [PMID:14741191] biological_process GO:0034276 kynurenic acid biosynthetic process synonyms "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [];"kynurenic acid anabolism" EXACT [];"kynurenic acid biosynthesis" EXACT [];"kynurenic acid formation" RELATED [];"kynurenic acid synthesis" EXACT [];"kynurenine pathway" BROAD [] WAS "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [];"kynurenic acid anabolism" EXACT [];"kynurenic acid biosynthesis" EXACT [];"kynurenic acid formation" RELATED [];"kynurenic acid synthesis" EXACT [] biological_process GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan synonyms "'de novo' NAD biosynthetic process from L-tryptophan" EXACT [];"'de novo' NAD biosynthetic process from tryptophan" BROAD [];"de novo NAD biosynthetic process from tryptophan" RELATED [];"kynurenine pathway" BROAD [] WAS "'de novo' NAD biosynthetic process from L-tryptophan" EXACT [];"'de novo' NAD biosynthetic process from tryptophan" BROAD [];"de novo NAD biosynthetic process from tryptophan" RELATED [] biological_process GO:0042883 L-cysteine transport name L-cysteine transport WAS cysteine transport definition "The directed movement of L-cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] WAS "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] synonyms "cysteine transport" BROAD [] WAS "L-cysteine transport" NARROW [] biological_process GO:0043639 benzoate catabolic process definition "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl, MetaCyc:PWY-7402] WAS "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl] biological_process GO:0045022 early endosome to late endosome transport definition "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes." [ISBN:0815316194, PMID:29980602] WAS "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602] biological_process GO:0045041 protein import into mitochondrial intermembrane space definition "The import of proteins from the cytosol across the outer mitochondrial membrane into the intermembrane space." [ISBN:0716731363] WAS "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] biological_process GO:0045136 development of animal secondary sexual characteristics name development of animal secondary sexual characteristics WAS development of secondary sexual characteristics definition "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In mammals, examples include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] WAS "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] synonyms "development of secondary sexual characteristics" EXACT [];"development of secondary sexual characteristics, sensu Metazoa" EXACT [] WAS N/A biological_process GO:0045337 trans, trans-farnesyl diphosphate biosynthetic process name trans, trans-farnesyl diphosphate biosynthetic process WAS farnesyl diphosphate biosynthetic process definition "The chemical reactions and pathways resulting in the formation of 2-trans,6-trans-farnesyl diphosphate from prenyl diphosphate." [MetaCyc:PWY-5123] WAS "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl] synonyms "farnesyl diphosphate anabolism" EXACT [];"farnesyl diphosphate biosynthesis" EXACT [];"farnesyl diphosphate biosynthetic process" BROAD [];"farnesyl diphosphate formation" EXACT [];"farnesyl diphosphate synthesis" EXACT [] WAS "farnesyl diphosphate anabolism" EXACT [];"farnesyl diphosphate biosynthesis" EXACT [];"farnesyl diphosphate formation" EXACT [];"farnesyl diphosphate synthesis" EXACT [] biological_process GO:0045490 pectin catabolic process definition "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [PMID:11931668, PMID:23079077] WAS "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:curators, PMID:11931668] biological_process GO:0046543 development of animal secondary female sexual characteristics name development of animal secondary female sexual characteristics WAS development of secondary female sexual characteristics definition "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female mammals, examples include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] WAS "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] synonyms "development of secondary female sexual characteristics" EXACT [];"development of secondary female sexual characteristics, sensu Metazoa" EXACT [] WAS N/A biological_process GO:0046544 development of animal secondary male sexual characteristics name development of animal secondary male sexual characteristics WAS development of secondary male sexual characteristics definition "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male mammals, examples include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] WAS "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] synonyms "development of secondary male sexual characteristics" EXACT [];"development of secondary male sexual characteristics, sensu Metazoa" EXACT [] WAS N/A biological_process GO:0046951 ketone body biosynthetic process synonyms "ketogenesis" EXACT [];"ketone body anabolism" EXACT [];"ketone body biosynthesis" EXACT [];"ketone body formation" EXACT [];"ketone body synthesis" EXACT [] WAS "ketone body anabolism" EXACT [];"ketone body biosynthesis" EXACT [];"ketone body formation" EXACT [];"ketone body synthesis" EXACT [] biological_process GO:0048208 COPII vesicle coat assembly name COPII vesicle coat assembly WAS COPII vesicle coating synonyms "COPII coating of ER-derived vesicle" EXACT [GOC:tb];"COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb];"COPII vesicle coating" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] WAS "COPII coating of ER-derived vesicle" EXACT [GOC:tb];"COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb];"COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] biological_process GO:0070147 mitochondrial cysteinyl-tRNA aminoacylation definition "The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] WAS "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] biological_process GO:0071941 nitrogen cycle metabolic process subsets gocheck_do_not_annotate;goslim_chembl;goslim_generic;goslim_pombe;goslim_prokaryote WAS goslim_chembl;goslim_generic;goslim_pombe;goslim_prokaryote biological_process GO:0080145 intracellular cysteine homeostasis definition "A homeostatic process involved in the maintenance of a steady state level of L-cysteine within a cell." [PMID:19955263] WAS "A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell." [PMID:19955263] biological_process GO:0097712 trans-Golgi to periciliary membrane compartment transport name trans-Golgi to periciliary membrane compartment transport WAS vesicle targeting, trans-Golgi to periciliary membrane compartment definition "The directed movement of substances from the trans-Golgi network to the periciliary membrane compartment, the specialized region of the plasma membrane surrounding the base of the cilium including the ciliary pocket, via vesicle-mediated transport." [PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645] WAS "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645] synonyms "vesicle targeting, trans-Golgi to periciliary membrane compartment" RELATED [] WAS N/A biological_process GO:0140053 mitochondrial gene expression definition "The process of transcribing and translating the mitochondrial genome (mtDNA) to produce at least a subset of oxidative phosphorylation (OXPHOS) proteins, 2 rRNAs, and mitochondrial tRNAs, which are critical for ATP production. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308, PMID:31861673, PMID:38117001] WAS "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] biological_process GO:0160203 protein import into the intermembrane space via the disulfide relay system name protein import into the intermembrane space via the disulfide relay system WAS mitochondrial disulfide relay system definition "The import of small cysteine-containing proteins from the cytosol across the outer mitochondrial membrane via the TOM complex driven by oxidative folding." [PMID:32936885, PMID:37159021] WAS "A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation." [PMID:32936885, PMID:37159021] synonyms "CHCHD4/Mia40-dependent import" NARROW [];"MIA pathway" EXACT [];"mitochondrial disulfide relay system" EXACT [];"mitochondrial intermembrane space assembly pathway" EXACT [] WAS "MIA pathway" EXACT [];"mitochondrial intermembrane space assembly pathway" EXACT [] biological_process GO:0170038 proteinogenic amino acid biosynthetic process subsets gocheck_do_not_annotate WAS N/A biological_process GO:0170039 proteinogenic amino acid metabolic process subsets gocheck_do_not_annotate WAS N/A biological_process GO:0170040 proteinogenic amino acid catabolic process subsets gocheck_do_not_annotate WAS N/A biological_process GO:0170043 non-proteinogenic amino acid biosynthetic process subsets gocheck_do_not_annotate WAS N/A biological_process GO:0170044 non-proteinogenic amino acid catabolic process subsets gocheck_do_not_annotate WAS N/A biological_process GO:1901788 benzoyl-CoA catabolic process definition "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361] WAS "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739] biological_process GO:1901810 beta-carotene metabolic process definition "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, PMID:11387982, UniPathway:UPA00802] WAS "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] biological_process GO:1901811 beta-carotene catabolic process definition "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, PMID:11387982, UniPathway:UPA00802] WAS "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] biological_process GO:1901826 zeaxanthin catabolic process definition "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00843] WAS "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] biological_process GO:1901997 negative regulation of indoleacetic acid biosynthetic process name negative regulation of indoleacetic acid biosynthetic process WAS negative regulation of indoleacetic acid biosynthetic process via tryptophan synonyms "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie];"inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid biosynthetic process via tryptophan" NARROW [];"negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] WAS "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie];"inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie];"negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie];"negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] biological_process GO:1902223 erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process definition "The chemical reactions and pathways resulting in the formation of an L-amino acid derived from erythrose 4-phosphate and phosphoenolpyruvate (L-phenylalanine, L-tyrosine and L-tryptophan)." [GOC:curators] WAS "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] biological_process GO:1903712 L-cysteine transmembrane transport name L-cysteine transmembrane transport WAS cysteine transmembrane transport definition "The directed movement of L-cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223] WAS "The directed movement of cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223] synonyms "cysteine transmembrane transport" BROAD [] WAS N/A biological_process GO:1904541 mating projection tip cell wall disassembly name mating projection tip cell wall disassembly WAS fungal-type cell wall disassembly involved in conjugation with cellular fusion definition "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion, where the cell wall is locally disassembled to enable conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517] WAS "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517] synonyms "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie];"fungal-type cell wall disassembly involved in conjugation with cellular fusion" EXACT [];"fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie] WAS "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie];"fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie] biological_process GO:1990799 mitochondrial tRNA wobble position uridine thiolation definition "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps." [PMID:15509579] WAS "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579] molecular_function GO:0000268 peroxisome signal sequence receptor activity name peroxisome signal sequence receptor activity WAS peroxisome targeting sequence binding definition "Binding to a peroxisomal targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the peroxisome." [PMID:20659419] WAS "Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonyms "peroxisome targeting sequence binding" NARROW [];"peroxisome targeting signal receptor" NARROW [];"PTS binding" EXACT [];"PTS receptor" NARROW [] WAS "peroxisome targeting signal receptor" NARROW [];"PTS binding" EXACT [];"PTS receptor" NARROW [] molecular_function GO:0003875 ADP-ribosylarginine-[protein] hydrolase activity name ADP-ribosylarginine-[protein] hydrolase activity WAS ADP-ribosylarginine hydrolase activity synonyms "ADP-ribose-L-arginine cleavage enzyme activity" RELATED [EC:3.2.2.19];"ADP-ribose-L-arginine cleaving enzyme activity" RELATED [EC:3.2.2.19];"ADP-ribosylarginine hydrolase activity" EXACT [];"ADPribosylarginine hydrolase activity" EXACT [];"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"protein ADP-ribosylarginine hydrolase activity" RELATED [EC:3.2.2.19];"protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] WAS "ADP-ribose-L-arginine cleavage enzyme activity" RELATED [EC:3.2.2.19];"ADP-ribose-L-arginine cleaving enzyme activity" RELATED [EC:3.2.2.19];"ADPribosylarginine hydrolase activity" EXACT [];"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19];"protein ADP-ribosylarginine hydrolase activity" RELATED [EC:3.2.2.19];"protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] molecular_function GO:0004729 protoporphyrinogen oxidase activity, oxygen as acceptor name protoporphyrinogen oxidase activity, oxygen as acceptor WAS oxygen-dependent protoporphyrinogen oxidase activity synonyms "oxygen-dependent protoporphyrinogen oxidase activity" EXACT [];"protoporphyrinogen-IX:oxygen oxidoreductase activity" RELATED [EC:1.3.3.4] WAS "protoporphyrinogen-IX:oxygen oxidoreductase activity" RELATED [EC:1.3.3.4] molecular_function GO:0005048 signal sequence receptor activity name signal sequence receptor activity WAS signal sequence binding definition "Binding to a signal sequence, a short stretch of amino acids found in a protein that acts as a signal for its proper localization in the cell." [GOC:curators] WAS "Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] synonyms "leader sequence binding" NARROW [];"protein signal sequence binding" NARROW [];"signal sequence binding" NARROW [];"signal sequence receptor" NARROW [] WAS "leader sequence binding" NARROW [];"protein signal sequence binding" NARROW [];"signal sequence receptor" NARROW [] molecular_function GO:0008093 cytoskeletal adaptor activity name cytoskeletal adaptor activity WAS cytoskeletal anchor activity synonyms "cytoskeletal anchor activity" NARROW [] WAS "cytoskeletal adaptor activity" EXACT [] molecular_function GO:0008253 5'-nucleotidase activity synonyms "5' nucleotidase activity" EXACT [];"5'-adenylic phosphatase" NARROW [EC:3.1.3.5];"5'-AMP nucleotidase" NARROW [EC:3.1.3.5];"5'-AMPase" NARROW [EC:3.1.3.5];"5'-mononucleotidase activity" RELATED [EC:3.1.3.5];"5'-ribonucleotide phosphohydrolase activity" NARROW [EC:3.1.3.5];"adenosine 5'-phosphatase" NARROW [EC:3.1.3.5];"adenosine monophosphatase" NARROW [EC:3.1.3.5];"AMP phosphatase" NARROW [EC:3.1.3.5];"AMP phosphohydrolase" NARROW [EC:3.1.3.5];"AMPase" NARROW [EC:3.1.3.5];"snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5];"thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5];"UMPase" NARROW [EC:3.1.3.5];"uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] WAS "5' nucleotidase activity" EXACT [];"5'-adenylic phosphatase" NARROW [EC:3.1.3.5];"5'-AMP nucleotidase" NARROW [EC:3.1.3.5];"5'-AMPase" NARROW [EC:3.1.3.5];"5'-mononucleotidase activity" RELATED [EC:3.1.3.5];"5'-ribonucleotide phosphohydrolase activity" RELATED [EC:3.1.3.5];"adenosine 5'-phosphatase" NARROW [EC:3.1.3.5];"adenosine monophosphatase" NARROW [EC:3.1.3.5];"AMP phosphatase" NARROW [EC:3.1.3.5];"AMP phosphohydrolase" NARROW [EC:3.1.3.5];"AMPase" NARROW [EC:3.1.3.5];"snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5];"thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5];"UMPase" NARROW [EC:3.1.3.5];"uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] molecular_function GO:0008805 aerobic carbon monoxide dehydrogenase activity name aerobic carbon monoxide dehydrogenase activity WAS carbon-monoxide oxygenase activity synonyms "carbon monoxide oxidase activity" RELATED [];"carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [];"carbon monoxide oxygenase activity" EXACT [];"carbon monoxide,water:cytochrome b-561 oxidoreductase activity" RELATED [];"carbon monoxide:methylene blue oxidoreductase activity" NARROW [];"carbon-monoxide dehydrogenase (cytochrome b-561)" RELATED [];"carbon-monoxide oxygenase activity" BROAD [];"cytochrome b561" NARROW [] WAS "carbon monoxide oxidase activity" RELATED [];"carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [];"carbon monoxide oxygenase activity" EXACT [];"carbon monoxide,water:cytochrome b-561 oxidoreductase activity" RELATED [];"carbon monoxide:methylene blue oxidoreductase activity" NARROW [];"carbon-monoxide dehydrogenase (cytochrome b-561)" RELATED [];"cytochrome b561" NARROW [] molecular_function GO:0008873 gluconate 2-dehydrogenase (NADP+) activity name gluconate 2-dehydrogenase (NADP+) activity WAS gluconate 2-dehydrogenase activity synonyms "2-keto-D-gluconate reductase activity" RELATED [EC:1.1.1.215];"2-ketogluconate reductase activity" RELATED [EC:1.1.1.215];"gluconate 2-dehydrogenase activity" BROAD [] WAS "2-keto-D-gluconate reductase activity" RELATED [EC:1.1.1.215];"2-ketogluconate reductase activity" RELATED [EC:1.1.1.215] molecular_function GO:0008874 gluconate 5-dehydrogenase [NAD(P)+] activity name gluconate 5-dehydrogenase [NAD(P)+] activity WAS gluconate 5-dehydrogenase activity synonyms "5-keto-D-gluconate 5-reductase activity" RELATED [EC:1.1.1.69];"5-keto-D-gluconate reductase" RELATED [EC:1.1.1.69];"5-ketogluconate 5-reductase activity" RELATED [EC:1.1.1.69];"5-ketogluconate reductase activity" RELATED [EC:1.1.1.69];"D-gluconate:NAD(P)+ 5-oxidoreductase" RELATED [EC:1.1.1.69];"gluconate 5-dehydrogenase activity" EXACT [] WAS "5-keto-D-gluconate 5-reductase activity" RELATED [EC:1.1.1.69];"5-keto-D-gluconate reductase" RELATED [EC:1.1.1.69];"5-ketogluconate 5-reductase activity" RELATED [EC:1.1.1.69];"5-ketogluconate reductase activity" RELATED [EC:1.1.1.69];"D-gluconate:NAD(P)+ 5-oxidoreductase" RELATED [EC:1.1.1.69] molecular_function GO:0008941 nitric oxide dioxygenase [NAD(P)H] activity name nitric oxide dioxygenase [NAD(P)H] activity WAS nitric oxide dioxygenase NAD(P)H activity molecular_function GO:0030343 vitamin D 25-hydroxylase activity name vitamin D 25-hydroxylase activity WAS vitamin D3 25-hydroxylase activity synonyms "cholecalciferol 25-hydroxylase activity" EXACT [];"vitamin D3 25-hydroxylase activity" EXACT [] WAS "cholecalciferol 25-hydroxylase activity" EXACT [] molecular_function GO:0030674 protein-macromolecule adaptor activity comment Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity. WAS N/A synonyms "protein binding, bridging" EXACT [];"protein recruiting activity" RELATED [];"protein-protein adaptor" NARROW [] WAS "protein binding, bridging" EXACT [];"protein complex scaffold activity" BROAD [];"protein recruiting activity" RELATED [];"protein-containing complex scaffold activity" BROAD [];"protein-protein adaptor" NARROW [] molecular_function GO:0030941 chloroplast targeting sequence receptor activity name chloroplast targeting sequence receptor activity WAS chloroplast targeting sequence binding definition "Binding to a chloroplast targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the chloroplast." [PMID:35929083] WAS "Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] synonyms "chloroplast targeting sequence binding" NARROW [] WAS N/A molecular_function GO:0030942 endoplasmic reticulum signal sequence receptor activity name endoplasmic reticulum signal sequence receptor activity WAS endoplasmic reticulum signal peptide binding definition "Binding to an endoplasmic reticulum signal peptide, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the endoplasmic reticulum." [GOC:mah] WAS "Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] synonyms "endoplasmic reticulum signal peptide binding" NARROW [];"ER signal peptide binding" EXACT [] WAS "ER signal peptide binding" EXACT [] molecular_function GO:0033229 L-cysteine transmembrane transporter activity name L-cysteine transmembrane transporter activity WAS cysteine transmembrane transporter activity definition "Enables the transfer of L-cysteine from one side of a membrane to the other." [GOC:mah] WAS "Enables the transfer of cysteine from one side of a membrane to the other." [GOC:mah] synonyms "cysteine transmembrane transporter activity" BROAD [] WAS N/A molecular_function GO:0033230 ABC-type L-cysteine transporter activity name ABC-type L-cysteine transporter activity WAS ABC-type cysteine transporter activity synonyms "ABC-type cysteine transporter activity" BROAD [];"ATP-dependent cysteine transporter activity" BROAD [];"ATPase-coupled cysteine transmembrane transporter activity" RELATED [];"ATPase-coupled cysteine transporter activity" RELATED [];"cysteine exporter" RELATED [];"cysteine-exporting ATPase activity" RELATED [];"cysteine-transporting ATPase activity" BROAD [] WAS "ATP-dependent cysteine transporter activity" EXACT [];"ATPase-coupled cysteine transmembrane transporter activity" RELATED [];"ATPase-coupled cysteine transporter activity" RELATED [];"cysteine exporter" RELATED [];"cysteine-exporting ATPase activity" RELATED [];"cysteine-transporting ATPase activity" EXACT [] molecular_function GO:0039630 RNA translocase activity comment N/A WAS Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. molecular_function GO:0043712 (R)-2-hydroxy-4-methylpentanoate CoA-transferase activity name (R)-2-hydroxy-4-methylpentanoate CoA-transferase activity WAS 2-hydroxyisocaproate CoA-transferase activity synonyms "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [];"2-hydroxyisocaproate CoA-transferase activity" EXACT [];"https://github.com/geneontology/go-ontology/issues/31862" EXACT [] WAS "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [];"(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] molecular_function GO:0046923 ER lumen protein retrieval receptor activity name ER lumen protein retrieval receptor activity WAS ER retention sequence binding definition "Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER." [GOC:ai] WAS "Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] synonyms "endoplasmic reticulum retention sequence binding" EXACT [];"ER retention sequence binding" NARROW [] WAS "endoplasmic reticulum retention sequence binding" EXACT [] molecular_function GO:0047074 hydroxyquinol 1,2-dioxygenase activity name hydroxyquinol 1,2-dioxygenase activity WAS 4-hydroxycatechol 1,2-dioxygenase activity synonyms "4-hydroxycatechol 1,2-dioxygenase activity" EXACT [] WAS N/A molecular_function GO:0047081 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity name 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity WAS 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity synonyms "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" RELATED [EC:1.14.13.242];"3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)" RELATED [EC:1.14.13.242];"3-hydroxy-2-methylpyridinecarboxylate dioxygenase [NAD(P)H] activity" RELATED [];"3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" RELATED [EC:1.14.13.242];"methylhydroxypyridine carboxylate dioxygenase activity" RELATED [EC:1.14.13.242];"methylhydroxypyridinecarboxylate oxidase activity" RELATED [EC:1.14.13.242] WAS "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" RELATED [EC:1.14.13.242];"3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)" RELATED [EC:1.14.13.242];"3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" RELATED [EC:1.14.13.242];"methylhydroxypyridine carboxylate dioxygenase activity" RELATED [EC:1.14.13.242];"methylhydroxypyridinecarboxylate oxidase activity" RELATED [EC:1.14.13.242] molecular_function GO:0050067 L-lysine 2-monooxygenase activity name L-lysine 2-monooxygenase activity WAS lysine 2-monooxygenase activity synonyms "L-lysine-2-monooxygenase activity" RELATED [EC:1.13.12.2];"L-lysine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.2];"lysine 2-monooxygenase activity" EXACT [];"lysine monooxygenase activity" RELATED [EC:1.13.12.2];"lysine oxygenase activity" RELATED [EC:1.13.12.2] WAS "L-lysine-2-monooxygenase activity" RELATED [EC:1.13.12.2];"L-lysine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.2];"lysine monooxygenase activity" RELATED [EC:1.13.12.2];"lysine oxygenase activity" RELATED [EC:1.13.12.2] molecular_function GO:0050607 S-(hydroxymethyl)mycothiol dehydrogenase activity name S-(hydroxymethyl)mycothiol dehydrogenase activity WAS mycothiol-dependent formaldehyde dehydrogenase activity synonyms "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [];"mycothiol-dependent formaldehyde dehydrogenase activity" EXACT [];"NAD/factor-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.306] WAS "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [];"NAD/factor-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.306] molecular_function GO:0070007 glutamic-type endopeptidase activity is_obsolete False WAS True name glutamic-type endopeptidase activity WAS obsolete glutamic-type endopeptidase activity definition "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] WAS "OBSOLETE. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] comment Unobsoleted, since similar terms exist. WAS This term was obsoleted because it represents a specific substrate. molecular_function GO:0070819 protoporphyrinogen oxidase activity, quinone as acceptor name protoporphyrinogen oxidase activity, quinone as acceptor WAS menaquinone-dependent protoporphyrinogen oxidase activity synonyms "menaquinone-dependent protoporphyrinogen oxidase activity" NARROW [];"protoporphyrinogen-IX:menaquinone oxidoreductase activity" NARROW [GOC:mah];"quinone-dependent protoporphyrinogen oxidase activity" EXACT [] WAS "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah] molecular_function GO:0102157 sulfopropanediol 3-dehydrogenase activity name sulfopropanediol 3-dehydrogenase activity WAS (R)-sulfopropanediol 2-dehydrogenase activity molecular_function GO:0102177 4alpha-monomethylsterol monooxygenase activity name 4alpha-monomethylsterol monooxygenase activity WAS 24-methylenelophenol methyl oxidase activity synonyms "24-methylenelophenol methyl oxidase activity" EXACT [] WAS N/A molecular_function GO:0102394 L-isoleucine 4-hydroxylase activity name L-isoleucine 4-hydroxylase activity WAS 4-hydroxy-L-isoleucine dehydrogenase activity synonyms "4-hydroxy-L-isoleucine dehydrogenase activity" RELATED [] WAS N/A molecular_function GO:0106145 scopoletin 8-hydroxylase activity definition "Catalysis of the reaction WAS "Catalyzes of the reaction molecular_function GO:0140177 membrane-membrane adaptor activity definition "The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex, vesicle or organelle." [GOC:curators] WAS "The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle." [GOC:curators] molecular_function GO:0140292 ADP-ribosylserine-[protein] hydrolase activity name ADP-ribosylserine-[protein] hydrolase activity WAS ADP-ribosylserine hydrolase activity synonyms "ADP-ribosylserine hydrolase activity" EXACT [] WAS N/A molecular_function GO:0140293 ADP-ribosylglutamate-[protein] hydrolase activity name ADP-ribosylglutamate-[protein] hydrolase activity WAS ADP-ribosylglutamate hydrolase activity synonyms "ADP-ribosylglutamate hydrolase activity" EXACT [] WAS N/A molecular_function GO:0140443 mitochondrion-plasma membrane adaptor activity definition "The binding activity of a molecule that brings together a mitochondrial outer membrane and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398] WAS "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398] molecular_function GO:0140474 mitochondrion-endoplasmic reticulum membrane tether activity definition "The binding activity of a molecule that brings together a mitochondrial outer membrane and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684] WAS "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684] molecular_function GO:0140506 endoplasmic reticulum-autophagosome adaptor activity definition "The binding activity of a molecule that brings together an ER membrane and an autophagosome membrane during reticulophagy." [PMID:32735772] WAS "The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy." [PMID:32735772] molecular_function GO:0140580 mitochondrion autophagosome adaptor activity definition "The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome membrane during mitophagy." [PMID:33138913] WAS "The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy." [PMID:33138913] molecular_function GO:0140597 protein carrier activity definition "Directly binding to a protein and delivering it either to an acceptor molecule or to a specific location." [PMID:7628437] WAS "Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein." [PMID:7628437] molecular_function GO:0140740 ADP-riboxanase-[protein] activity name ADP-riboxanase-[protein] activity WAS ADP-riboxanase activity synonyms "ADP-riboxanase activity" EXACT [] WAS N/A molecular_function GO:0160183 autophagosome-membrane adaptor activity definition "The binding activity of a molecule that brings together a target membrane and an autophagosome membrane during autophagy." [PMID:30544615, PMID:36635405] WAS "The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy." [PMID:30544615, PMID:36635405] molecular_function GO:0160190 peroxisome-mitochondrion membrane tether activity definition "The binding activity of a molecule that brings together the peroxisome membrane and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion." [PMID:29720625, PMID:38669296] WAS "The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion." [PMID:29720625, PMID:38669296] molecular_function GO:0160229 peroxisome-endoplasmic reticulum membrane tether activity definition "The binding activity of a molecule that brings together a peroxisome membrane and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein." [PMID:39271061] WAS "The binding activity of a molecule that brings together a peroxisome and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein." [PMID:39271061] molecular_function GO:0170016 endoplasmic reticulum-endosome tether activity definition "The binding activity of a molecule that brings together an endosome membrane and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange." [PMID:33124732] WAS "The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange." [PMID:33124732] 260 CROSS REFERENCES CHANGES biological_process GO:0000103 sulfate assimilation xrefs MetaCyc:SO4ASSIM-PWY;MetaCyc:SULFMETII-PWY WAS N/A biological_process GO:0000256 allantoin catabolic process xrefs MetaCyc:ALLANTOINDEG-PWY;MetaCyc:PWY0-41 WAS N/A biological_process GO:0002353 plasma kallikrein-kinin cascade xrefs Reactome:R-HSA-9970672 "FXIIa activates plasma kallikrein-kinin system" WAS N/A biological_process GO:0002862 negative regulation of inflammatory response to antigenic stimulus xrefs Reactome:R-HSA-9662851 "Anti-inflammatory response favouring Leishmania parasite infection" WAS Reactome:R-HSA-9660821 "ADORA2B mediated anti-inflammatory cytokines production";Reactome:R-HSA-9662834 "CD163 mediating an anti-inflammatory response";Reactome:R-HSA-9664323 "FCGR3A-mediated IL10 synthesis";Reactome:R-HSA-9664535 "LTC4-CYSLTR mediated IL4 production" biological_process GO:0005978 glycogen biosynthetic process xrefs MetaCyc:GLYCOGENSYNTH-PWY;MetaCyc:PWY-5067;MetaCyc:PWY-7900;Reactome:R-HSA-3322077 "Glycogen synthesis" WAS MetaCyc:PWY-7900;Reactome:R-HSA-3322077 "Glycogen synthesis" biological_process GO:0005980 glycogen catabolic process xrefs MetaCyc:GLYCOCAT-PWY;MetaCyc:PWY-5941;MetaCyc:PWY-7662;Reactome:R-HSA-70221 "Glycogen breakdown (glycogenolysis)" WAS MetaCyc:PWY-7662;Reactome:R-HSA-70221 "Glycogen breakdown (glycogenolysis)" biological_process GO:0005987 sucrose catabolic process xrefs MetaCyc:PWY-621;MetaCyc:SUCUTIL-PWY WAS N/A biological_process GO:0005990 lactose catabolic process xrefs MetaCyc:BGALACT-PWY;MetaCyc:LACTOSECAT-PWY;MetaCyc:LACTOSEUTIL-PWY WAS MetaCyc:BGALACT-PWY biological_process GO:0006096 glycolytic process xrefs MetaCyc:GLYCOLYSIS-VARIANTS;MetaCyc:P341-PWY WAS MetaCyc:GLYCOLYSIS-VARIANTS biological_process GO:0006479 protein methylation xrefs N/A WAS Reactome:R-HSA-8876725 "Protein methylation" biological_process GO:0006525 arginine metabolic process xrefs N/A WAS Wikipedia:Arginine biological_process GO:0006536 glutamate metabolic process xrefs N/A WAS Wikipedia:Glutamic_acid biological_process GO:0006555 L-methionine metabolic process xrefs N/A WAS UM-BBD_pathwayID:met biological_process GO:0006563 L-serine metabolic process xrefs N/A WAS Reactome:R-HSA-977347 "Serine metabolism" biological_process GO:0006567 L-threonine catabolic process xrefs MetaCyc:PWY-5436;MetaCyc:PWY-5437;MetaCyc:PWY66-428;MetaCyc:THRDLCTCAT-PWY;MetaCyc:THREONINE-DEG2-PWY;Reactome:R-HSA-8849175 "Threonine catabolism";UM-BBD_pathwayID:met WAS MetaCyc:PWY-5436;MetaCyc:PWY-5437;MetaCyc:PWY66-428;MetaCyc:THRDLCTCAT-PWY;MetaCyc:THREONINE-DEG2-PWY;UM-BBD_pathwayID:met biological_process GO:0006572 L-tyrosine catabolic process xrefs MetaCyc:PWY-5151;MetaCyc:PWY-7514;MetaCyc:PWY-8016;MetaCyc:PWY3O-4108;MetaCyc:TYRFUMCAT-PWY;Reactome:R-HSA-8963684 "Tyrosine catabolism";UM-BBD_pathwayID:tyr WAS MetaCyc:PWY-5151;MetaCyc:PWY-7514;MetaCyc:PWY-8016;MetaCyc:PWY3O-4108;MetaCyc:TYRFUMCAT-PWY;Reactome:R-HSA-8963684 "Tyrosine catabolism" biological_process GO:0006596 polyamine biosynthetic process xrefs MetaCyc:POLYAMINSYN3-PWY;MetaCyc:POLYAMSYN-PWY;Reactome:R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)";Reactome:R-HSA-351200 "Interconversion of polyamines" WAS MetaCyc:POLYAMINSYN3-PWY;MetaCyc:POLYAMSYN-PWY;Reactome:R-HSA-351200 "Interconversion of polyamines" biological_process GO:0006602 creatinine catabolic process xrefs MetaCyc:CRNFORCAT-PWY;MetaCyc:PWY-4722;MetaCyc:PWY-4741 WAS N/A biological_process GO:0006635 fatty acid beta-oxidation xrefs MetaCyc:PWY-5137;MetaCyc:PWY-5138;Reactome:R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" WAS Reactome:R-HSA-77289 "Mitochondrial Fatty Acid Beta-Oxidation" biological_process GO:0006656 phosphatidylcholine biosynthetic process xrefs MetaCyc:PWY-6825;MetaCyc:PWY-6826;MetaCyc:PWY-7470;MetaCyc:PWY4FS-2;MetaCyc:PWY4FS-3;MetaCyc:PWY4FS-4;Reactome:R-HSA-1483191 "Synthesis of PC" WAS Reactome:R-HSA-1483191 "Synthesis of PC" biological_process GO:0006695 cholesterol biosynthetic process xrefs MetaCyc:PWY66-3;MetaCyc:PWY66-341;MetaCyc:PWY66-4;Reactome:R-HSA-191273 "Cholesterol biosynthesis" WAS Reactome:R-HSA-191273 "Cholesterol biosynthesis" biological_process GO:0006780 uroporphyrinogen III biosynthetic process xrefs MetaCyc:PWY-5188;MetaCyc:PWY-5189 WAS N/A biological_process GO:0007597 blood coagulation, intrinsic pathway xrefs N/A WAS Reactome:R-HSA-140837 "Intrinsic Pathway of Fibrin Clot Formation" biological_process GO:0007598 blood coagulation, extrinsic pathway xrefs N/A WAS Reactome:R-HSA-140834 "Extrinsic Pathway of Fibrin Clot Formation" biological_process GO:0009236 cobalamin biosynthetic process xrefs MetaCyc:P381-PWY;MetaCyc:PWY-5507 WAS N/A biological_process GO:0009298 GDP-mannose biosynthetic process xrefs MetaCyc:PWY-5659 {status="skos:exactMatch"};Reactome:R-HSA-446205 "Synthesis of GDP-mannose" WAS Reactome:R-HSA-446205 "Synthesis of GDP-mannose" biological_process GO:0009446 putrescine biosynthetic process xrefs MetaCyc:PWY-40;MetaCyc:PWY-43;MetaCyc:PWY-46 WAS N/A biological_process GO:0009447 putrescine catabolic process xrefs MetaCyc:PUTDEG-PWY;MetaCyc:PWY-0;MetaCyc:PWY-2;MetaCyc:PWY-3;MetaCyc:PWY0-1221 WAS N/A biological_process GO:0009450 GABA catabolic process xrefs MetaCyc:4AMINOBUTMETAB-PWY;MetaCyc:PWY-5022;MetaCyc:PWY-6473;MetaCyc:PWY-6535;MetaCyc:PWY-6536;MetaCyc:PWY-6537;Reactome:R-HSA-916853 "Degradation of GABA" WAS MetaCyc:PWY-5022;MetaCyc:PWY-6473;MetaCyc:PWY-6535;MetaCyc:PWY-6536;MetaCyc:PWY-6537;Reactome:R-HSA-916853 "Degradation of GABA" biological_process GO:0009684 indoleacetic acid biosynthetic process xrefs MetaCyc:PWY-3161;MetaCyc:PWY-5025;MetaCyc:PWY-5026;MetaCyc:PWY-581;MetaCyc:PWY-6303;MetaCyc:PWYDQC-4;MetaCyc:TRPIAACAT-PWY WAS N/A biological_process GO:0010264 myo-inositol hexakisphosphate biosynthetic process xrefs MetaCyc:PWY-4661;MetaCyc:PWY-6362;MetaCyc:PWY-6372;MetaCyc:PWY-6554;MetaCyc:PWY-6555 WAS N/A biological_process GO:0016260 L-selenocysteine biosynthetic process xrefs MetaCyc:PWY-6281;MetaCyc:PWY0-901;Reactome:R-HSA-2408557 "Selenocysteine synthesis" WAS MetaCyc:PWY-6281;MetaCyc:PWY0-901 biological_process GO:0019244 pyruvate fermentation to lactate xrefs MetaCyc:PWY-5481;MetaCyc:PWY-8274 WAS N/A biological_process GO:0019254 carnitine metabolic process, CoA-linked xrefs N/A WAS MetaCyc:CARNMET-PWY biological_process GO:0019329 ammonia oxidation xrefs MetaCyc:PWY-2242 WAS N/A biological_process GO:0019381 atrazine catabolic process xrefs MetaCyc:P141-PWY;MetaCyc:PWY-5724;UM-BBD_pathwayID:atr WAS MetaCyc:PWY-5724;UM-BBD_pathwayID:atr biological_process GO:0019396 gallate catabolic process xrefs MetaCyc:GALLATE-DEGRADATION-I-PWY;MetaCyc:GALLATE-DEGRADATION-II-PWY;MetaCyc:P3-PWY;UM-BBD_pathwayID:gal WAS UM-BBD_pathwayID:gal biological_process GO:0019417 sulfur oxidation xrefs MetaCyc:FESULFOX-PWY;MetaCyc:PWY-5294;MetaCyc:PWY-5304;MetaCyc:SULFUROX-PWY WAS N/A biological_process GO:0019418 sulfide oxidation xrefs MetaCyc:P222-PWY;MetaCyc:PWY-5274;MetaCyc:PWY-5285;MetaCyc:PWY-7927 WAS MetaCyc:Sulfide-Oxidation biological_process GO:0019571 D-arabinose catabolic process xrefs MetaCyc:DARABCAT-PWY WAS N/A biological_process GO:0019572 L-arabinose catabolic process xrefs MetaCyc:ARABCAT-PWY {status="skos:narrowMatch"} WAS N/A biological_process GO:0019596 (R)-mandelate catabolic process xrefs MetaCyc:PWY-1501;MetaCyc:PWY-6957 WAS N/A biological_process GO:0019600 toluene oxidation xrefs MetaCyc:TOLUENE-DEG-2-OH-PWY;MetaCyc:TOLUENE-DEG-3-OH-PWY;MetaCyc:TOLUENE-DEG-4-OH-PWY;MetaCyc:TOLUENE-DEG-CATECHOL-PWY;MetaCyc:TOLUENE-DEG-DIOL-PWY WAS N/A biological_process GO:0019649 formaldehyde assimilation xrefs MetaCyc:P185-PWY;MetaCyc:PWY-1861 WAS N/A biological_process GO:0019761 glucosinolate biosynthetic process xrefs MetaCyc:PWY-1187;MetaCyc:PWY-2821 WAS N/A biological_process GO:0019853 L-ascorbic acid biosynthetic process xrefs MetaCyc:PWY-882 WAS N/A biological_process GO:0030645 acetyl-CoA fermentation to butanoate xrefs MetaCyc:PWY-5676 WAS Metacyc:PWY-5676 biological_process GO:0031456 glycine betaine biosynthetic process xrefs MetaCyc:BETSYN-PWY;MetaCyc:P541-PWY;MetaCyc:PWY-3722;MetaCyc:PWY1F-353 WAS N/A biological_process GO:0033305 chlorophyll a biosynthetic process xrefs MetaCyc:PWY-5064;MetaCyc:PWY-5086 WAS N/A biological_process GO:0033536 ajugose biosynthetic process xrefs MetaCyc:PWY-5342;MetaCyc:PWY-5343 WAS N/A biological_process GO:0042216 phenanthrene catabolic process xrefs UM-BBD_pathwayID:pha2;UM-BBD_pathwayID:pha3;UM-BBD_pathwayID:phe WAS UM-BBD_pathwayID:phe biological_process GO:0042413 carnitine catabolic process xrefs MetaCyc:;MetaCyc:CARNMET-PWY;MetaCyc:PWY-3602;MetaCyc:PWY-3641;MetaCyc:PWY-8307 WAS N/A biological_process GO:0042425 choline biosynthetic process xrefs MetaCyc:PWY-3385;MetaCyc:PWY-3542;MetaCyc:PWY-3561;MetaCyc:PWY-4762 WAS MetaCyc:PWY-4762 biological_process GO:0043639 benzoate catabolic process xrefs MetaCyc:PWY-2503;MetaCyc:PWY-283;MetaCyc:PWY-7402 WAS N/A biological_process GO:0045063 T-helper 1 cell differentiation xrefs Reactome:R-HSA-9942503 "Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)" WAS Reactome:R-HSA-9942503 "Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)" biological_process GO:0045312 nor-spermidine biosynthetic process xrefs MetaCyc:PWY-6562 WAS N/A biological_process GO:0045490 pectin catabolic process xrefs MetaCyc:PWY-1081;MetaCyc:PWY-7246;MetaCyc:PWY-7248 WAS N/A biological_process GO:0046363 ribitol catabolic process xrefs MetaCyc:PWY-8394;MetaCyc:RIBITOLUTIL-PWY WAS N/A biological_process GO:0046951 ketone body biosynthetic process xrefs MetaCyc:PWY66-367;Reactome:R-HSA-77111 "Synthesis of Ketone Bodies" WAS Reactome:R-HSA-77111 "Synthesis of Ketone Bodies" biological_process GO:0051159 D-arabitol catabolic process xrefs MetaCyc:DARABITOLUTIL-PWY;MetaCyc:PWY-8392 WAS N/A biological_process GO:0051711 negative regulation of killing of cells of another organism xrefs N/A WAS Reactome:R-HSA-9662851 "Anti-inflammatory response favouring Leishmania parasite infection" biological_process GO:0052699 ergothioneine biosynthetic process xrefs MetaCyc:PWY-7255;MetaCyc:PWY-7550 WAS N/A biological_process GO:0055085 transmembrane transport xrefs Reactome:R-HSA-382556 "ABC-family protein mediated transport";Reactome:R-HSA-425407 "SLC-mediated transmembrane transport";Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" WAS Reactome:R-HSA-382556 "ABC-family proteins mediated transport";Reactome:R-HSA-425407 "SLC-mediated transmembrane transport";Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" biological_process GO:0060271 cilium assembly xrefs Reactome:R-HSA-5617833 "Cilium Assembly";Reactome:R-HSA-5620920 "Cargo trafficking to the periciliary membrane" WAS Reactome:R-HSA-5617833 "Cilium Assembly" biological_process GO:0061678 Entner-Doudoroff pathway xrefs MetaCyc:ENTNER-DOUDOROFF-PWY;MetaCyc:NPGLUCAT-PWY;MetaCyc:PWY-2221;MetaCyc:PWY-8004 WAS MetaCyc:Entner-Doudoroff-Pathways biological_process GO:0070585 protein localization to mitochondrion xrefs Reactome:R-HSA-1268020 "Mitochondrial protein import" WAS N/A biological_process GO:0070981 L-asparagine biosynthetic process xrefs MetaCyc:ASPARAGINE-BIOSYNTHESIS;MetaCyc:ASPARAGINESYN-PWY;MetaCyc:PWY490-4 WAS MetaCyc:ASPARAGINE-BIOSYNTHESIS;MetaCyc:ASPARAGINESYN-PWY biological_process GO:0071267 L-methionine salvage xrefs MetaCyc:ADENOSYLHOMOCYSCAT-PWY;MetaCyc:PWY-4361;MetaCyc:PWY-7174;MetaCyc:PWY-7270;MetaCyc:PWY-7527;MetaCyc:PWY-7528;MetaCyc:PWY-8132;Reactome:R-HSA-1237112 "Methionine salvage pathway" WAS MetaCyc:ADENOSYLHOMOCYSCAT-PWY;MetaCyc:PWY-4361;MetaCyc:PWY-7174;MetaCyc:PWY-7270;MetaCyc:PWY-7527;MetaCyc:PWY-7528;MetaCyc:PWY-8132 biological_process GO:1901177 lycopene biosynthetic process xrefs MetaCyc:PWY-5942;MetaCyc:PWY-6475 WAS N/A biological_process GO:1902777 6-sulfoquinovose(1-) catabolic process xrefs MetaCyc:PWY-7446 WAS N/A molecular_function GO:0000140 acylglycerone-phosphate reductase (NADP+) activity xrefs EC:1.1.1.101;MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN;MetaCyc:RXN-15046;Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P";RHEA:17341;RHEA:36175;RHEA:40939;RHEA:66452 WAS EC:1.1.1.101;MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN;MetaCyc:RXN-15046;Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P";RHEA:17341;RHEA:36175 molecular_function GO:0000252 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity xrefs EC:1.1.1.170;Reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one";Reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)";Reactome:R-HSA-9945787 "NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one";Reactome:R-HSA-9945822 "NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol";RHEA:20673;RHEA:33447;RHEA:34771;RHEA:60088;RHEA:60096 WAS EC:1.1.1.170;Reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one";Reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)";Reactome:R-HSA-9945787 "NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one";Reactome:R-HSA-9945822 "NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol";RHEA:34771 molecular_function GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity xrefs EC:2.1.1.71;KEGG_REACTION:R01320;KEGG_REACTION:R03424;MetaCyc:2.1.1.71-RXN;MetaCyc:RXN4FS-2;RHEA:32735;RHEA:32739;RHEA:46112;RHEA:70623;RHEA:70743;RHEA:70747;RHEA:70755;RHEA:70759;RHEA:70767;RHEA:70771 WAS EC:2.1.1.71;KEGG_REACTION:R01320;KEGG_REACTION:R03424;MetaCyc:2.1.1.71-RXN;MetaCyc:RXN4FS-2;RHEA:32735;RHEA:32739 molecular_function GO:0003810 protein-glutamine gamma-glutamyltransferase activity xrefs EC:2.3.2.13;MetaCyc:2.3.2.13-RXN;Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+";Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking";Reactome:R-HSA-9921091 "IIb3:fibrin multimer ->IIb3:fibrin multimer, crosslinked + NH4+";RHEA:54816 WAS EC:2.3.2.13;MetaCyc:2.3.2.13-RXN;Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+";Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking";RHEA:54816 molecular_function GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity xrefs EC:2.4.3.8;MetaCyc:2.4.99.8-RXN;Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues";Reactome:R-HSA-422454 "Polysialylation of NCAM1";Reactome:R-HSA-9845587 "ST8SIA5 transfers Neu5Ac to gangliosides";RHEA:19313;RHEA:41760;RHEA:41768;RHEA:41772;RHEA:48288;RHEA:48912;RHEA:48924;RHEA:48928;RHEA:48932;RHEA:77387 WAS EC:2.4.3.8;MetaCyc:2.4.99.8-RXN;Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues";Reactome:R-HSA-422454 "Polysialylation of NCAM1";Reactome:R-HSA-9845587 "ST8SIA5 transfers Neu5Ac to gangliosides";RHEA:19313;RHEA:48288;RHEA:48912;RHEA:48924;RHEA:48932;RHEA:77387 molecular_function GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity xrefs EC:2.4.3.1;MetaCyc:RXN-18268;Reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)";Reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-977071 "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens";RHEA:11836;RHEA:21552;RHEA:52104;RHEA:56268;RHEA:82903;RHEA:82947;RHEA:82983 WAS EC:2.4.3.1;MetaCyc:RXN-18268;Reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)";Reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans";Reactome:R-HSA-977071 "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens";RHEA:11836;RHEA:21552;RHEA:52104;RHEA:56268;RHEA:82903;RHEA:82947 molecular_function GO:0003837 beta-ureidopropionase activity xrefs EC:3.5.1.6;MetaCyc:BETA-UREIDOPROPIONASE-RXN;Reactome:R-HSA-73591 "conversion of 3-ureidopropionate to beta-alanine";Reactome:R-HSA-73620 "conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate";RHEA:11184 WAS EC:3.5.1.6;MetaCyc:BETA-UREIDOPROPIONASE-RXN;Reactome:R-HSA-73591 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2";Reactome:R-HSA-73620 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2";RHEA:11184 molecular_function GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity xrefs EC:2.3.1.51;MetaCyc:RXN-1623;Reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT";Reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT";Reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)";Reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7";Reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT";Reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT";Reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)";Reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)";Reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)";Reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine";RHEA:19709;RHEA:33187;RHEA:33315;RHEA:33319;RHEA:35903;RHEA:35907;RHEA:35911;RHEA:35915;RHEA:37131;RHEA:37135;RHEA:37139;RHEA:37143;RHEA:37147;RHEA:37151;RHEA:37155;RHEA:37159;RHEA:37163;RHEA:37171;RHEA:37175;RHEA:37179;RHEA:37183;RHEA:37187;RHEA:37223;RHEA:37427;RHEA:37435;RHEA:37439;RHEA:37443;RHEA:37451;RHEA:37455;RHEA:37595;RHEA:37603;RHEA:37607;RHEA:42588;RHEA:55304 WAS EC:2.3.1.51;MetaCyc:RXN-1623;Reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT";Reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT";Reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)";Reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7";Reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT";Reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT";Reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)";Reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)";Reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)";Reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine";RHEA:19709;RHEA:33187;RHEA:33315;RHEA:33319;RHEA:35911;RHEA:35915;RHEA:37135;RHEA:37139;RHEA:37151;RHEA:37155;RHEA:37159;RHEA:37163;RHEA:37171;RHEA:37175;RHEA:37179;RHEA:37183;RHEA:37187;RHEA:37223;RHEA:37427;RHEA:37435;RHEA:37439;RHEA:37451;RHEA:37595;RHEA:37603;RHEA:37607 molecular_function GO:0003846 2-acylglycerol O-acyltransferase activity xrefs EC:2.3.1.22;MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN;Reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG";Reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG";RHEA:16741;RHEA:32947;RHEA:37911;RHEA:38051;RHEA:38059;RHEA:38063;RHEA:38067;RHEA:38071;RHEA:38075;RHEA:38079;RHEA:38083;RHEA:38087;RHEA:38467;RHEA:39951;RHEA:77271;RHEA:77275;RHEA:77279;RHEA:77283;RHEA:77287;RHEA:77291;RHEA:77539;RHEA:77543;RHEA:77547 WAS EC:2.3.1.22;MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN;Reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG";Reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG";RHEA:16741;RHEA:32947;RHEA:38467;RHEA:39951;RHEA:77271;RHEA:77275;RHEA:77279;RHEA:77283;RHEA:77287;RHEA:77291;RHEA:77539;RHEA:77543;RHEA:77547 molecular_function GO:0003851 N-acylsphingosine galactosyltransferase activity xrefs EC:2.4.1.47;MetaCyc:2.4.1.47-RXN;Reactome:R-HSA-6785933 "UGT8 transfers Gal from UDP-Gal to CERA";RHEA:10856;RHEA:13093;RHEA:43400;RHEA:44896 WAS EC:2.4.1.47;MetaCyc:2.4.1.47-RXN;Reactome:R-HSA-6785933 "UGT8 transfers Gal from UDP-Gal to CERA";RHEA:10856;RHEA:13093;RHEA:44896 molecular_function GO:0003853 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity xrefs EC:1.3.8.5;KEGG_REACTION:R03169;MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN;RHEA:43780;RHEA:44180;RHEA:48256 WAS EC:1.3.8.5;KEGG_REACTION:R03169;MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN;RHEA:43780;RHEA:44180 molecular_function GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity xrefs EC:1.1.1.145;MetaCyc:1.1.1.145-RXN;Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one";Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one";Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one";Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione";Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol";RHEA:24076;RHEA:43932;RHEA:56932 WAS EC:1.1.1.145;MetaCyc:1.1.1.145-RXN;Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one";Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one";Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one";Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione";Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol";RHEA:24076;RHEA:43932 molecular_function GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity xrefs EC:1.1.1.35;MetaCyc:OHACYL-COA-DEHYDROG-RXN;Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA";Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA";Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+";Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA";Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+";Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA";Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+";Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H";Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H";Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H";Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H";Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H";Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H";Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H";RHEA:22432;RHEA:30799;RHEA:31143;RHEA:31179;RHEA:31187;RHEA:31195;RHEA:34851;RHEA:40211;RHEA:78919;RHEA:78923;RHEA:83003;RHEA:84419;RHEA:84683;RHEA:84687;UM-BBD_reactionID:r1063 WAS EC:1.1.1.35;MetaCyc:OHACYL-COA-DEHYDROG-RXN;Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA";Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA";Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+";Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA";Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+";Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA";Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+";Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H";Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H";Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H";Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H";Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H";Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H";Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H";RHEA:22432;RHEA:34851;RHEA:40211;RHEA:78919;RHEA:78923;UM-BBD_reactionID:r1063 molecular_function GO:0003875 ADP-ribosylarginine-[protein] hydrolase activity xrefs EC:3.2.2.19;MetaCyc:3.2.2.24-RXN {xref="skos:narrowMatch"};MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN;MetaCyc:RXN-8732;RHEA:14493;RHEA:14885;RHEA:20784 WAS EC:3.2.2.19;MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN;MetaCyc:RXN-8732;RHEA:14885;RHEA:20784 molecular_function GO:0003883 CTP synthase activity xrefs EC:6.3.4.2;MetaCyc:CTPSYN-RXN;Reactome:R-HSA-504054 "Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)";Reactome:R-HSA-73647 "Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)";RHEA:26426 WAS EC:6.3.4.2;MetaCyc:CTPSYN-RXN;Reactome:R-HSA-504054 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]";Reactome:R-HSA-73647 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]";RHEA:26426 molecular_function GO:0003909 DNA ligase activity xrefs Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand";Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA";Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA";Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break";Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB";Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB";Reactome:R-HSA-5686663 "Completion of SSA";Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ";Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER";Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ";Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER";Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments";Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway" WAS Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand";Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA";Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA";Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break";Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB";Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB";Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ";Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER";Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ";Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER";Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments";Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway" molecular_function GO:0003920 GMP reductase activity xrefs EC:1.7.1.7;KEGG_REACTION:R01134;MetaCyc:GMP-REDUCT-RXN;Reactome:R-HSA-514604 "GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)";RHEA:17185 WAS EC:1.7.1.7;KEGG_REACTION:R01134;MetaCyc:GMP-REDUCT-RXN;Reactome:R-HSA-514604 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)";RHEA:17185 molecular_function GO:0003968 RNA-directed RNA polymerase activity xrefs EC:2.7.7.48;MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN;Reactome:R-HSA-168280 "Priming and Initiation of Transcription";Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination";Reactome:R-HSA-192624 "cRNA Extension";Reactome:R-HSA-192832 "Initiation of cRNA Synthesis";Reactome:R-HSA-192851 "vRNA Extension";Reactome:R-HSA-192916 "Initiation of vRNA Synthesis";Reactome:R-HSA-9681651 "nsp8 generates RNA primers";Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement";Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA";Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs";Reactome:R-HSA-9694277 "nsp8 generates RNA primers";Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs";Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA";Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement";Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9828639 "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs";Reactome:R-HSA-9834719 "Synthesis of negative sense genomic RNA of respiratory syncytial virus";Reactome:R-HSA-9834736 "Synthesis of antigenomic RNA of human respiratory syncytial virus";Reactome:R-HSA-9837511 "Abortive replication of hRSV A";Reactome:R-HSA-9922955 "NS5 synthesizes minus strand genome";Reactome:R-HSA-9923068 "NS5 synthesizes plus strand genome";Reactome:R-HSA-9944255 "CHD6 negatively regulates influenza transcription";Reactome:R-HSA-9944257 "CHD6 negatively regulates positive strand RNA synthesis" WAS EC:2.7.7.48;MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN;Reactome:R-HSA-168280 "Priming and Initiation of Transcription";Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination";Reactome:R-HSA-192624 "cRNA Extension";Reactome:R-HSA-192832 "Initiation of cRNA Synthesis";Reactome:R-HSA-192851 "vRNA Extension";Reactome:R-HSA-192916 "Initiation of vRNA Synthesis";Reactome:R-HSA-9681651 "nsp8 generates RNA primers";Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement";Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA";Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs";Reactome:R-HSA-9694277 "nsp8 generates RNA primers";Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching";Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs";Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement";Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA";Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement";Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand";Reactome:R-HSA-9828639 "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs";Reactome:R-HSA-9834719 "Synthesis of negative sense genomic RNA of respiratory syncytial virus";Reactome:R-HSA-9834736 "Synthesis of antigenomic RNA of human respiratory syncytial virus";Reactome:R-HSA-9837511 "Abortive replication of hRSV A";Reactome:R-HSA-9922955 "NS5 synthesizes minus strand genome";Reactome:R-HSA-9923068 "NS5 synthesizes plus strand genome" molecular_function GO:0003988 acetyl-CoA C-acyltransferase activity xrefs EC:2.3.1.16;MetaCyc:KETOACYLCOATHIOL-RXN;Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA";Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH => Lauroyl-CoA + acetyl-CoA";Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA";Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH => Decanoyl-CoA + acetyl-CoA";Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA";Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA";Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH => Octanoyl-CoA + acetyl-CoA";Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH";RHEA:21564;RHEA:31087;RHEA:31091;RHEA:31111;RHEA:31183;RHEA:31203;RHEA:34799;RHEA:35279;RHEA:39131;RHEA:39147;RHEA:46312;RHEA:47400;RHEA:47444;RHEA:47460;RHEA:67224;RHEA:78567;RHEA:78583;RHEA:78599;RHEA:78639;RHEA:78895;RHEA:78899;RHEA:78903;RHEA:78907;RHEA:82935;RHEA:82943;RHEA:83007;RHEA:83083;RHEA:83095;RHEA:83099;RHEA:83135;RHEA:83219;RHEA:83251;RHEA:83331;RHEA:83367;RHEA:83383;RHEA:83399;RHEA:84447;RHEA:84451;RHEA:84455;RHEA:84459;RHEA:84695;RHEA:84699;RHEA:84703;RHEA:84707;RHEA:84711;RHEA:84715;RHEA:84839;UM-BBD_reactionID:r1051 WAS EC:2.3.1.16;MetaCyc:KETOACYLCOATHIOL-RXN;Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA";Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA";Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA";Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA";Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA";Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA";Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA";Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH";RHEA:21564;RHEA:34799;RHEA:46312;RHEA:67224;RHEA:78895;RHEA:78899;RHEA:78903;RHEA:78907;UM-BBD_reactionID:r1051 molecular_function GO:0003995 acyl-CoA dehydrogenase activity xrefs MetaCyc:ACYLCOADEHYDROG-RXN;Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA";Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA";Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA";Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2";Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2";Reactome:R-HSA-77263 "lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2";Reactome:R-HSA-77274 "myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77299 "palmitoyl-CoA+FAD => trans-Hexadec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77319 "Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2";Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2";Reactome:R-HSA-77338 "Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2";Reactome:R-HSA-77345 "Decanoyl-CoA+FAD => trans-Dec-2-enoyl-CoA+FADH2";RHEA:44704 WAS MetaCyc:ACYLCOADEHYDROG-RXN;Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA";Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA";Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA";Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2";Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2";Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2";Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2";Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2";Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2";Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2";Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2";RHEA:44704 molecular_function GO:0004022 alcohol dehydrogenase (NAD+) activity xrefs EC:1.1.1.1;MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN;MetaCyc:RXN-12448;Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+";Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+";RHEA:10736;RHEA:10740;RHEA:12216;RHEA:12785;RHEA:13221;RHEA:15757;RHEA:16317;RHEA:16821;RHEA:23552;RHEA:30027;RHEA:32343;RHEA:34347;RHEA:35463;RHEA:35615;RHEA:37167;RHEA:38215;RHEA:41984;RHEA:42012;RHEA:42016;RHEA:42020;RHEA:42052;RHEA:42056;RHEA:42060;RHEA:42184;RHEA:42188;RHEA:43924;RHEA:45120;RHEA:48728;RHEA:48748;RHEA:48756;RHEA:48760;RHEA:50704;RHEA:55936;RHEA:58848;RHEA:60632;RHEA:60668;RHEA:60672;RHEA:60676;RHEA:60712;RHEA:60972;RHEA:60976;RHEA:60980;RHEA:60984;RHEA:60988;RHEA:62064;RHEA:62392;RHEA:63260;RHEA:63740;RHEA:64060;RHEA:64068;RHEA:64516;RHEA:64560;RHEA:64692;RHEA:64700;RHEA:64704;RHEA:68108;RHEA:70231;RHEA:75115;RHEA:75419;RHEA:75423;RHEA:79419;RHEA:80735;RHEA:81603;RHEA:86103;RHEA:86111;RHEA:86115;RHEA:86119 WAS EC:1.1.1.1;MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN;MetaCyc:RXN-12448;Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+";Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+";RHEA:10736;RHEA:10740 molecular_function GO:0004029 aldehyde dehydrogenase (NAD+) activity xrefs EC:1.2.1.3;MetaCyc:ALDHDEHYDROG-RXN;Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid";Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate";Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM";Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH";Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG";Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG";Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA";Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]";Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]";Reactome:R-HSA-9970035 "Unknown ALDH oxidizes methylimidazolealdehyde";Reactome:R-HSA-9971429 "Unknown ALDH oxidizes 10-oxo-DECA";Reactome:R-HSA-9971446 "Unknown ALDH oxidizes 3-AAPNAL";RHEA:16185;RHEA:30867;RHEA:30879;RHEA:31043;RHEA:31059;RHEA:31215;RHEA:31231;RHEA:31243;RHEA:31259;RHEA:31299;RHEA:31515;RHEA:33803;RHEA:34219;RHEA:39039;RHEA:42340;RHEA:42384;RHEA:45764;RHEA:47932;RHEA:59432;RHEA:60688;RHEA:60708;RHEA:61632;RHEA:67252;RHEA:67256;RHEA:69080;RHEA:69084;RHEA:69088;RHEA:69164;RHEA:69168;RHEA:75119;RHEA:76655;RHEA:76667;RHEA:81191;RHEA:81419;UM-BBD_reactionID:r0003;UM-BBD_reactionID:r0023;UM-BBD_reactionID:r0605;Wikipedia:Aldehyde_dehydrogenase_(NAD+) WAS EC:1.2.1.3;MetaCyc:ALDHDEHYDROG-RXN;Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid";Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate";Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM";Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH";Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG";Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG";Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA";Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]";Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]";RHEA:16185;RHEA:30867;RHEA:30879;RHEA:31043;RHEA:31059;RHEA:31215;RHEA:31231;RHEA:31243;RHEA:31259;RHEA:31299;RHEA:31515;RHEA:33803;RHEA:34219;RHEA:39039;RHEA:42340;RHEA:42384;RHEA:45764;RHEA:47152;RHEA:47932;RHEA:59432;RHEA:60688;RHEA:60708;RHEA:61632;RHEA:67252;RHEA:67256;RHEA:69080;RHEA:69084;RHEA:69088;RHEA:69164;RHEA:69168;RHEA:75119;RHEA:76655;RHEA:76667;RHEA:81191;RHEA:81419;UM-BBD_reactionID:r0003;UM-BBD_reactionID:r0023;UM-BBD_reactionID:r0605;Wikipedia:Aldehyde_dehydrogenase_(NAD+) molecular_function GO:0004046 aminoacylase activity xrefs EC:3.5.1.14;MetaCyc:AMINOACYLASE-RXN;Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids";Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids";Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids";Reactome:R-HSA-9753944 "ACY1:Zn2+ dimer deacetylates NAC to L-Cys";RHEA:15565;RHEA:36855;RHEA:47124;RHEA:49796;RHEA:51300;RHEA:51312;RHEA:51316;RHEA:51352;RHEA:51356;RHEA:51360;RHEA:51444;RHEA:51456;RHEA:51460;RHEA:52628;RHEA:54184;RHEA:54188;RHEA:64108;RHEA:64112;RHEA:64116;RHEA:64120;RHEA:64124;RHEA:64128;RHEA:64132;RHEA:64136;RHEA:64140;RHEA:64144;RHEA:64156;RHEA:64176;RHEA:64180;RHEA:64184;RHEA:64188;RHEA:64192;RHEA:64196;RHEA:64200;RHEA:64208;RHEA:64212;RHEA:67368;RHEA:67440;RHEA:75515;RHEA:81115;RHEA:81119;RHEA:81123 WAS EC:3.5.1.14;MetaCyc:AMINOACYLASE-RXN;Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids";Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids";Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids";Reactome:R-HSA-9753944 "ACY1:Zn2+ dimer deacetylates NAC to L-Cys";RHEA:15565;RHEA:36855;RHEA:52628;RHEA:54184;RHEA:67368;RHEA:67440;RHEA:75515;RHEA:81115;RHEA:81119;RHEA:81123 molecular_function GO:0004090 carbonyl reductase (NADPH) activity xrefs EC:1.1.1.184;MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN;Reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL";RHEA:10724;RHEA:12212;RHEA:13829;RHEA:16321;RHEA:16817;RHEA:18941;RHEA:19257;RHEA:25960;RHEA:25964;RHEA:31891;RHEA:32339;RHEA:32619;RHEA:35607;RHEA:36587;RHEA:42500;RHEA:42768;RHEA:45116;RHEA:47540;RHEA:53820;RHEA:62068;RHEA:62072;RHEA:62080;RHEA:62216;RHEA:62268;RHEA:63476;RHEA:63480;RHEA:63504;RHEA:64416;RHEA:65056;RHEA:65060;RHEA:65496;RHEA:68136;RHEA:68140;RHEA:68144;RHEA:68148;RHEA:70215;RHEA:70219;RHEA:74707;RHEA:81575;RHEA:81583;RHEA:81719;RHEA:82231;RHEA:84223;RHEA:85047;RHEA:85103 WAS EC:1.1.1.184;MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN;Reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL";RHEA:10724;RHEA:12212;RHEA:13829;RHEA:16321;RHEA:16817;RHEA:18941;RHEA:19257;RHEA:25960;RHEA:31891;RHEA:32339;RHEA:32619;RHEA:35607;RHEA:36587;RHEA:42500;RHEA:42768;RHEA:45116;RHEA:47540;RHEA:53820;RHEA:62068;RHEA:62216;RHEA:62268;RHEA:63476;RHEA:63480;RHEA:63504;RHEA:64416;RHEA:65056;RHEA:65060;RHEA:65496;RHEA:68136;RHEA:68140;RHEA:68144;RHEA:68148;RHEA:70215;RHEA:70219;RHEA:74707;RHEA:81575;RHEA:81583;RHEA:81719;RHEA:82231;RHEA:84223;RHEA:85047;RHEA:85103 molecular_function GO:0004126 cytidine deaminase activity xrefs EC:3.5.4.5;MetaCyc:CYTIDEAM-RXN;MetaCyc:CYTIDEAM2-RXN;Reactome:R-HSA-73608 "deamination of 2'-Deoxycytidine to 2'-Deoxyuridine";Reactome:R-HSA-83677 "C4 deamination of cytidine";Reactome:R-HSA-9817513 "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine";RHEA:13433;RHEA:16069 WAS EC:3.5.4.5;MetaCyc:CYTIDEAM-RXN;MetaCyc:CYTIDEAM2-RXN;Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)";Reactome:R-HSA-83677 "C4 deamination of cytidine";Reactome:R-HSA-9817513 "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine";RHEA:13433;RHEA:16069 molecular_function GO:0004155 6,7-dihydropteridine reductase activity xrefs EC:1.5.1.34;MetaCyc:1.5.1.34-RXN;Reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+";RHEA:17865;RHEA:17869;RHEA:32247;RHEA:32251 WAS EC:1.5.1.34;MetaCyc:1.5.1.34-RXN;Reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+";RHEA:17865;RHEA:17869 molecular_function GO:0004157 dihydropyrimidinase activity xrefs EC:3.5.2.2;MetaCyc:DIHYDROPYRIMIDINASE-RXN;Reactome:R-HSA-73589 "conversion of 5,6-dihydrouracil to 3-ureidopropionate";Reactome:R-HSA-73618 "conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate";RHEA:16121 WAS EC:3.5.2.2;MetaCyc:DIHYDROPYRIMIDINASE-RXN;Reactome:R-HSA-73589 "5,6-dihydrouracil + H2O => beta-ureidopropionate";Reactome:R-HSA-73618 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate";RHEA:16121 molecular_function GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity xrefs EC:5.3.3.8;MetaCyc:ENOYL-COA-DELTA-ISOM-RXN;MetaCyc:RXN-7836;MetaCyc:RXN-7931;Reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA";Reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA";RHEA:23716;RHEA:29847;RHEA:45228;RHEA:45736;RHEA:45748;RHEA:45752;RHEA:45900;RHEA:46044;RHEA:46068;RHEA:47464;RHEA:47476;RHEA:49852;RHEA:49932;RHEA:77195;RHEA:83231;RHEA:84487;RHEA:84491;RHEA:84547;RHEA:84555;RHEA:84559;RHEA:84563;RHEA:84843 WAS EC:5.3.3.8;MetaCyc:ENOYL-COA-DELTA-ISOM-RXN;MetaCyc:RXN-7836;MetaCyc:RXN-7931;Reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA";Reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA";RHEA:23716;RHEA:29847;RHEA:45228;RHEA:45748;RHEA:45900;RHEA:46044;RHEA:77195 molecular_function GO:0004170 dUTP diphosphatase activity xrefs EC:3.6.1.23;KEGG_REACTION:R02100;MetaCyc:DUTP-PYROP-RXN;Reactome:R-HSA-73666 "hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate";RHEA:10248 WAS EC:3.6.1.23;KEGG_REACTION:R02100;MetaCyc:DUTP-PYROP-RXN;Reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate";RHEA:10248 molecular_function GO:0004175 endopeptidase activity xrefs EC:3.4.99.-;Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded";Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha";Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate (26S proteasome catalyst)";Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)";Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex";Reactome:R-HSA-1433374 "Processing of SCF isoform 1";Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome";Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1";Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins";Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin";Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1";Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A";Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4";Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G";Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome";Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2";Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain";Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex";Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34";Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome";Reactome:R-HSA-2213200 "Release of endostatin-like peptides";Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1";Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex";Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome";Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2";Reactome:R-HSA-450466 "AUF1:mRNA complex is degraded";Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome";Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome";Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome";Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors";Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage";Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome";Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome";Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex";Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB";Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor";Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome";Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP";Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH";Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome";Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome";Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome";Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3";Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK";Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome";Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)";Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer";Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer";Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome";Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome";Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome";Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A";Reactome:R-HSA-74730 "Insulin degradation";Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1";Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin";Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN";Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53";Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7";Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7";Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome";Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome";Reactome:R-HSA-8932355 "26S proteasome degrades Ub-NFE2L2";Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin";Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2";Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome";Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH";Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2";Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2";Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)";Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1";Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4";Reactome:R-HSA-9614271 "Autocleavage of ADGRG6";Reactome:R-HSA-9755303 "26S proteasome degrades HIFalpha";Reactome:R-HSA-9755306 "ub UBXN7 is degraded by the 26S proteasome";Reactome:R-HSA-9760521 "Unknown peptidase cleaves pro-STa";Reactome:R-HSA-9762096 "Ub,pS335,S338,T NFE2L2 is degraded";Reactome:R-HSA-9766223 "Proteasome-dependent degradation of ubiquitinated CDH1";Reactome:R-HSA-983150 "Proteasomal cleavage of substrate";Reactome:R-HSA-983158 "Trimming of peptides in ER";Reactome:R-HSA-9839376 "TGFBR3(784-851) degradation";Reactome:R-HSA-9906017 "Unknown peptidase cleaves UQCRFS1 subunit";Reactome:R-HSA-9908101 "Maturation of the canonical 20S core particle";Reactome:R-HSA-9908105 "Maturation of the 20S immunoproteasome core particle";Reactome:R-HSA-9908108 "Maturation of the 20S thymoproteasome core particle";Reactome:R-HSA-9908780 "Maturation of the preholospermatoproteasome";Reactome:R-HSA-9912636 "Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)";Reactome:R-HSA-9912655 "Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)";Reactome:R-HSA-9912747 "Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)";Reactome:R-HSA-9912751 "Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)";Reactome:R-HSA-9929352 "Ubiquitinated CD274 is degraded by the 26S proteasome";Reactome:R-HSA-9929486 "SPOP-mediated degradation of CD274 by 26S Proteosome";Reactome:R-HSA-9931314 "Proteasomal degradation of polyUb-p-S195-CD274";Reactome:R-HSA-9934884 "Proteolysis of K48polyUb,p-S-CRY1,2";Reactome:R-HSA-9934887 "Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2";Reactome:R-HSA-9934893 "Proteolysis of K48polyUb-K,p-S-PER1,2,3";Reactome:R-HSA-9949676 "The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer";Reactome:R-HSA-9954728 "The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide";Reactome:R-HSA-9958874 "26S proteasome degrades ubiquitinated RAC1, CDC42" WAS EC:3.4.99.-;Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded";Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha";Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate (26S proteasome catalyst)";Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)";Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex";Reactome:R-HSA-1433374 "Processing of SCF isoform 1";Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome";Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1";Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins";Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin";Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1";Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A";Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4";Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G";Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome";Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2";Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain";Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex";Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34";Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome";Reactome:R-HSA-2213200 "Release of endostatin-like peptides";Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1";Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex";Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome";Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2";Reactome:R-HSA-450466 "AUF1:mRNA complex is degraded";Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome";Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome";Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome";Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors";Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage";Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome";Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome";Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex";Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB";Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor";Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome";Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP";Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH";Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome";Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome";Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome";Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3";Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK";Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome";Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)";Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer";Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer";Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome";Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome";Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome";Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A";Reactome:R-HSA-74730 "Insulin degradation";Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1";Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin";Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN";Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53";Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7";Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7";Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome";Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome";Reactome:R-HSA-8932355 "26S proteasome degrades Ub-NFE2L2";Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin";Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2";Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome";Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH";Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2";Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2";Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)";Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1";Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4";Reactome:R-HSA-9614271 "Autocleavage of ADGRG6";Reactome:R-HSA-9755303 "26S proteasome degrades HIFalpha";Reactome:R-HSA-9755306 "ub UBXN7 is degraded by the 26S proteasome";Reactome:R-HSA-9760521 "Unknown peptidase cleaves pro-STa";Reactome:R-HSA-9762096 "Ub,pS335,S338,T NFE2L2 is degraded";Reactome:R-HSA-9766223 "Proteasome-dependent degradation of ubiquitinated CDH1";Reactome:R-HSA-983150 "Proteasomal cleavage of substrate";Reactome:R-HSA-983158 "Trimming of peptides in ER";Reactome:R-HSA-9839376 "TGFBR3(784-851) degradation";Reactome:R-HSA-9906017 "Unknown peptidase cleaves UQCRFS1 subunit";Reactome:R-HSA-9908101 "Maturation of the canonical 20S core particle";Reactome:R-HSA-9908105 "Maturation of the 20S immunoproteasome core particle";Reactome:R-HSA-9908108 "Maturation of the 20S thymoproteasome core particle";Reactome:R-HSA-9908780 "Maturation of the preholospermatoproteasome";Reactome:R-HSA-9912636 "Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)";Reactome:R-HSA-9912655 "Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)";Reactome:R-HSA-9912747 "Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)";Reactome:R-HSA-9912751 "Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)";Reactome:R-HSA-9929352 "Ubiquitinated CD274 is degraded by the 26S proteasome";Reactome:R-HSA-9929486 "SPOP-mediated degradation of CD274 by 26S Proteosome";Reactome:R-HSA-9931314 "Proteasomal degradation of polyUb-p-S195-CD274";Reactome:R-HSA-9934884 "Proteolysis of K48polyUb,p-S-CRY1,2";Reactome:R-HSA-9934887 "Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2";Reactome:R-HSA-9934893 "Proteolysis of K48polyUb-K,p-S-PER1,2,3";Reactome:R-HSA-9949676 "The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer";Reactome:R-HSA-9954728 "The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide" molecular_function GO:0004185 serine-type carboxypeptidase activity xrefs EC:3.4.16.-;EC:3.4.16.2;EC:3.4.16.5;EC:3.4.16.6;MetaCyc:3.4.16.2-RXN;MetaCyc:3.4.16.5-RXN;Reactome:R-HSA-9857945 "prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst)" WAS EC:3.4.16.-;EC:3.4.16.2;EC:3.4.16.5;EC:3.4.16.6;MetaCyc:3.4.16.2-RXN;MetaCyc:3.4.16.5-RXN;Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer" molecular_function GO:0004222 metalloendopeptidase activity xrefs EC:3.4.24.-;EC:3.4.24.11;EC:3.4.24.14;EC:3.4.24.17;EC:3.4.24.18;EC:3.4.24.19;EC:3.4.24.21;EC:3.4.24.22;EC:3.4.24.23;EC:3.4.24.24;EC:3.4.24.3;EC:3.4.24.34;EC:3.4.24.35;EC:3.4.24.37;EC:3.4.24.55;EC:3.4.24.56;EC:3.4.24.57;EC:3.4.24.59;EC:3.4.24.61;EC:3.4.24.65;EC:3.4.24.69;EC:3.4.24.7;EC:3.4.24.70;EC:3.4.24.71;EC:3.4.24.72;MetaCyc:3.4.24.11-RXN;MetaCyc:3.4.24.14-RXN;MetaCyc:3.4.24.17-RXN;MetaCyc:3.4.24.18-RXN;MetaCyc:3.4.24.19-RXN;MetaCyc:3.4.24.21-RXN;MetaCyc:3.4.24.22-RXN;MetaCyc:3.4.24.23-RXN;MetaCyc:3.4.24.24-RXN;MetaCyc:3.4.24.35-RXN;MetaCyc:3.4.24.37-RXN;MetaCyc:3.4.24.55-RXN;MetaCyc:3.4.24.56-RXN;MetaCyc:3.4.24.57-RXN;MetaCyc:3.4.24.59-RXN;MetaCyc:3.4.24.61-RXN;MetaCyc:3.4.24.64-RXN;MetaCyc:3.4.24.69-RXN;MetaCyc:3.4.24.70-RXN;MetaCyc:3.4.24.71-RXN;MetaCyc:3.4.24.72-RXN;Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";Reactome:R-HSA-2022141 "Prolysyl oxidase activation";Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";Reactome:R-HSA-2514790 "Elastin degradation by MMP14";Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";Reactome:R-HSA-2537499 "Gelatin degradation by MMP19";Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";Reactome:R-HSA-3791319 "NID1 degradation by MMP19";Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";Reactome:R-HSA-5333671 "CLCAs self cleave";Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";Reactome:R-HSA-8940554 "MMP2 cleaves OPTC";Reactome:R-HSA-8940561 "MMP7 cleaves OPTC";Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";Reactome:R-HSA-8942302 "MMP13 cleaves OPTC";Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1";Reactome:R-HSA-9010034 "ADAM10:Zn2+:TSPANs cleaves APP(18-770)";Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";Reactome:R-HSA-9840532 "OMA1 self-cleaves";Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer";Reactome:R-HSA-9934645 "ADAMTS13 cleaves VWF multimer bound to FVIII" WAS EC:3.4.24.-;EC:3.4.24.11;EC:3.4.24.14;EC:3.4.24.17;EC:3.4.24.18;EC:3.4.24.19;EC:3.4.24.21;EC:3.4.24.22;EC:3.4.24.23;EC:3.4.24.24;EC:3.4.24.3;EC:3.4.24.34;EC:3.4.24.35;EC:3.4.24.37;EC:3.4.24.55;EC:3.4.24.56;EC:3.4.24.57;EC:3.4.24.59;EC:3.4.24.61;EC:3.4.24.65;EC:3.4.24.69;EC:3.4.24.7;EC:3.4.24.70;EC:3.4.24.71;EC:3.4.24.72;MetaCyc:3.4.24.11-RXN;MetaCyc:3.4.24.14-RXN;MetaCyc:3.4.24.17-RXN;MetaCyc:3.4.24.18-RXN;MetaCyc:3.4.24.19-RXN;MetaCyc:3.4.24.21-RXN;MetaCyc:3.4.24.22-RXN;MetaCyc:3.4.24.23-RXN;MetaCyc:3.4.24.24-RXN;MetaCyc:3.4.24.35-RXN;MetaCyc:3.4.24.37-RXN;MetaCyc:3.4.24.55-RXN;MetaCyc:3.4.24.56-RXN;MetaCyc:3.4.24.57-RXN;MetaCyc:3.4.24.59-RXN;MetaCyc:3.4.24.61-RXN;MetaCyc:3.4.24.64-RXN;MetaCyc:3.4.24.69-RXN;MetaCyc:3.4.24.70-RXN;MetaCyc:3.4.24.71-RXN;MetaCyc:3.4.24.72-RXN;Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR";Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17";Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors";Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors";Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13";Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2";Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14";Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14";Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14";Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13";Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11";Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13";Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3";Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12";Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2";Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10";Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1";Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9";Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13";Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs";Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF";Reactome:R-HSA-181567 "botC LC cleaves target cell STX1";Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25";Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2";Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25";Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1";Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1";Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25";Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides";Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides";Reactome:R-HSA-2022141 "Prolysyl oxidase activation";Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12";Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9";Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF";Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15";Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15";Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15";Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13";Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10";Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13";Reactome:R-HSA-2514790 "Elastin degradation by MMP14";Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14";Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14";Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10";Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14";Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15";Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7";Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15";Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7";Reactome:R-HSA-2537499 "Gelatin degradation by MMP19";Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1";Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)";Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5";Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19";Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14";Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13";Reactome:R-HSA-3791319 "NID1 degradation by MMP19";Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4";Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS";Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7";Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14";Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7";Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15";Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2";Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2";Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2";Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2";Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1";Reactome:R-HSA-5333671 "CLCAs self cleave";Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding";Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3";Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)";Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1";Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2";Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3";Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1";Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4";Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3";Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)";Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)";Reactome:R-HSA-8940554 "MMP2 cleaves OPTC";Reactome:R-HSA-8940561 "MMP7 cleaves OPTC";Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)";Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin";Reactome:R-HSA-8942302 "MMP13 cleaves OPTC";Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3";Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)";Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU";Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1";Reactome:R-HSA-9010034 "ADAM10:Zn2+:TSPANs cleaves APP(18-770)";Reactome:R-HSA-9624272 "MMPs cleave HB-EGF";Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer";Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer";Reactome:R-HSA-9840408 "OMA1 cleaves DELE1";Reactome:R-HSA-9840532 "OMA1 self-cleaves";Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1";Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer" molecular_function GO:0004252 serine-type endopeptidase activity xrefs EC:3.4.21.-;EC:3.4.21.1;EC:3.4.21.10;EC:3.4.21.102;EC:3.4.21.20;EC:3.4.21.21;EC:3.4.21.22;EC:3.4.21.26;EC:3.4.21.27;EC:3.4.21.34;EC:3.4.21.35;EC:3.4.21.36;EC:3.4.21.38;EC:3.4.21.39;EC:3.4.21.4;EC:3.4.21.41;EC:3.4.21.42;EC:3.4.21.43;EC:3.4.21.45;EC:3.4.21.46;EC:3.4.21.47;EC:3.4.21.48;EC:3.4.21.5;EC:3.4.21.53;EC:3.4.21.54;EC:3.4.21.59;EC:3.4.21.6;EC:3.4.21.61;EC:3.4.21.62;EC:3.4.21.68;EC:3.4.21.69;EC:3.4.21.7;EC:3.4.21.71;EC:3.4.21.73;EC:3.4.21.75;EC:3.4.21.78;EC:3.4.21.79;EC:3.4.21.83;EC:3.4.21.88;EC:3.4.21.9;EC:3.4.21.92;EC:3.4.21.93;EC:3.4.21.94;Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them";Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein";Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage";Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides";Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)";Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide (thrombin catalyst)";Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)";Reactome:R-HSA-140769 "factor VII -> factor VIIa";Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B";Reactome:R-HSA-140870 "thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate";Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form";Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C";Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin";Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2";Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases";Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases";Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS";Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer";Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)";Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)";Reactome:R-HSA-158313 "factor XII -> factor XIIa";Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)";Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)";Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin";Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)";Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin";Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)";Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)";Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)";Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE";Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2";Reactome:R-HSA-1592297 "Full activation of MMP1";Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)";Reactome:R-HSA-1592316 "Initial activation of proMMP1";Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3";Reactome:R-HSA-1592371 "Initial activation of proMMP3";Reactome:R-HSA-1592398 "Activation of proMMP8";Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs";Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin";Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X";Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C";Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S";Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX";Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII";Reactome:R-HSA-1602458 "Activation of proMMP10";Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN";Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1";Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN";Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin";Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7";Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14";Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2";Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs";Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin";Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases";Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3";Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13";Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)";Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3";Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7";Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z";Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6";Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b";Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b";Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases";Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN";Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein";Reactome:R-HSA-173626 "Activation of C1r";Reactome:R-HSA-173631 "Activation of C1s";Reactome:R-HSA-173680 "Activation of C5";Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B";Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase";Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein";Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B";Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a";Reactome:R-HSA-186785 "PDGF-AA clevage by Furin";Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF";Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH";Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN";Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))";Reactome:R-HSA-2129357 "Fibrillin C-terminal processing";Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release";Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding";Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding";Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1";Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins";Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding";Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE";Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2";Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE";Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS";Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)";Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1";Reactome:R-HSA-265301 "Corticotropin cleavage from POMC";Reactome:R-HSA-3244626 "DENV protease NS2B3 cleaves STING";Reactome:R-HSA-3266557 "Factor I cleaves iC3b";Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG";Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8";Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS";Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1";Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1";Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs";Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB";Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1";Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP";Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP";Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin";Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin";Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)";Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va";Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa";Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein";Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer";Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)";Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP";Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5";Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2";Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8";Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5";Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)";Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin";Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin";Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4";Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3";Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2";Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3";Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1";Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))";Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)";Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH";Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS";Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1";Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1";Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2";Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1";Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4";Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin";Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1";Reactome:R-HSA-9655840 "FXIIa is cleaved to -FXIIa";Reactome:R-HSA-9655850 "prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)";Reactome:R-HSA-9662786 "FURIN cleaves ADAM17";Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin";Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L";Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa";Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa";Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)";Reactome:R-HSA-9678434 "factor X -> factor Xa + factor X activation peptide (emicizumab:FIXa catalyst)";Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid";Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it";Reactome:R-HSA-9710106 "ELANE cleaves GSDMD";Reactome:R-HSA-9710263 "GZMB cleaves GSDME";Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b";Reactome:R-HSA-9769737 "factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)";Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage";Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion";Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b";Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b";Reactome:R-HSA-9816275 "CDH1 is proteolytically cleaved in Golgi";Reactome:R-HSA-9822513 "TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)";Reactome:R-HSA-9822514 "TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)";Reactome:R-HSA-9822522 "factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst)";Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane";Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)";Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated";Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane";Reactome:R-HSA-9839367 "TGFBR3_mem cleavage by MMPs";Reactome:R-HSA-9855735 "factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)";Reactome:R-HSA-9857814 "prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)";Reactome:R-HSA-9909046 "kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)";Reactome:R-HSA-9909048 "prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst)";Reactome:R-HSA-9911236 "ELANE cleaves NOTCH2NLA";Reactome:R-HSA-9911383 "LepB cleaves prepro-STa";Reactome:R-HSA-9912368 "LepB cleaves pre-EltA";Reactome:R-HSA-9912371 "LepB cleaves pre-EltB";Reactome:R-HSA-9913329 "Autoproteolysis of DAG1 to alpha and beta chains";Reactome:R-HSA-9918772 "Dengue polyprotein cis-auto-cleaves";Reactome:R-HSA-9918780 "Unknown peptidase cleaves NS1-NS2A";Reactome:R-HSA-9918787 "NS2B3 cleaves C-prM-E-NS1-NS2A";Reactome:R-HSA-9918795 "Signalase cleaves prM-E-NS1-NS2A";Reactome:R-HSA-9918813 "NS2B3 cleaves NS4AB";Reactome:R-HSA-9918817 "NS2B3 cleaves polyprotein";Reactome:R-HSA-9918823 "NS345:NS2B cleaves NS345";Reactome:R-HSA-9918871 "Signalase cleaves prepro-NS4B";Reactome:R-HSA-9918876 "NS2B3 cleaves prepro-C at the C-prM junction";Reactome:R-HSA-9919050 "Furin cleaves prM:E";Reactome:R-HSA-9921595 "NS2B3 cleaves FAM134B";Reactome:R-HSA-9921689 "NS3 cleaves GrpEL1";Reactome:R-HSA-9926936 "EspC(54-1018) cleaves hemoglobin";Reactome:R-HSA-9926963 "Hbp cis-autocleaves";Reactome:R-HSA-9927009 "Hbp(53-1100) cleaves hemoglobin";Reactome:R-HSA-9929051 "TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst)";Reactome:R-HSA-9929060 "TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst)";Reactome:R-HSA-9930440 "F5 R334T, I387T is not cleaved by activated protein C";Reactome:R-HSA-9930452 "F5 R534Q, A540V is not cleaved by activated protein C";Reactome:R-HSA-9930790 "factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)";Reactome:R-HSA-9930792 "factor Va intermediate -> factor Va";Reactome:R-HSA-9932162 "Removal of CDH1 signal peptide";Reactome:R-HSA-9936430 "factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)";Reactome:R-HSA-9936467 "factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst)";Reactome:R-HSA-9936906 "factor XII:-amyloid:Zn2+-> factor XIIa + -amyloid:Zn2+ (autocatalysis)";Reactome:R-HSA-9938539 "kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin";Reactome:R-HSA-9947496 "ACOT2 cleaves NS345" WAS EC:3.4.21.-;EC:3.4.21.1;EC:3.4.21.10;EC:3.4.21.102;EC:3.4.21.20;EC:3.4.21.21;EC:3.4.21.22;EC:3.4.21.26;EC:3.4.21.27;EC:3.4.21.34;EC:3.4.21.35;EC:3.4.21.36;EC:3.4.21.38;EC:3.4.21.39;EC:3.4.21.4;EC:3.4.21.41;EC:3.4.21.42;EC:3.4.21.43;EC:3.4.21.45;EC:3.4.21.46;EC:3.4.21.47;EC:3.4.21.48;EC:3.4.21.5;EC:3.4.21.53;EC:3.4.21.54;EC:3.4.21.59;EC:3.4.21.6;EC:3.4.21.61;EC:3.4.21.62;EC:3.4.21.68;EC:3.4.21.69;EC:3.4.21.7;EC:3.4.21.71;EC:3.4.21.73;EC:3.4.21.75;EC:3.4.21.78;EC:3.4.21.79;EC:3.4.21.83;EC:3.4.21.88;EC:3.4.21.9;EC:3.4.21.92;EC:3.4.21.93;EC:3.4.21.94;Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them";Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein";Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage";Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides";Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)";Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide (thrombin catalyst)";Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)";Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140769 "factor VII -> factor VIIa";Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)";Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)";Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B";Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin";Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form";Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C";Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin";Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2";Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases";Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases";Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS";Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer";Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)";Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)";Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin";Reactome:R-HSA-158313 "factor XII -> factor XIIa";Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)";Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)";Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin";Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)";Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin";Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)";Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)";Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)";Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE";Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2";Reactome:R-HSA-1592297 "Full activation of MMP1";Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)";Reactome:R-HSA-1592316 "Initial activation of proMMP1";Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3";Reactome:R-HSA-1592371 "Initial activation of proMMP3";Reactome:R-HSA-1592398 "Activation of proMMP8";Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs";Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin";Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X";Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C";Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S";Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX";Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII";Reactome:R-HSA-1602458 "Activation of proMMP10";Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN";Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1";Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN";Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin";Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7";Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14";Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2";Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs";Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin";Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases";Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3";Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13";Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)";Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3";Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7";Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z";Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6";Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2";Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b";Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b";Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases";Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by FURIN";Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein";Reactome:R-HSA-173626 "Activation of C1r";Reactome:R-HSA-173631 "Activation of C1s";Reactome:R-HSA-173680 "Activation of C5";Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B";Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase";Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein";Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B";Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a";Reactome:R-HSA-186785 "PDGF-AA clevage by Furin";Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF";Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH";Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN";Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))";Reactome:R-HSA-2129357 "Fibrillin C-terminal processing";Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release";Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding";Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding";Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1";Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins";Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding";Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE";Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2";Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE";Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS";Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)";Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1";Reactome:R-HSA-265301 "Corticotropin cleavage from POMC";Reactome:R-HSA-3244626 "DENV protease NS2B3 cleaves STING";Reactome:R-HSA-3266557 "Factor I cleaves iC3b";Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG";Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8";Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)";Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS";Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1";Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS";Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1";Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs";Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB";Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1";Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP";Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP";Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin";Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin";Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)";Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)";Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va";Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa";Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein";Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer";Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer";Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)";Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP";Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5";Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2";Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8";Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5";Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)";Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin";Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin";Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)";Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4";Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3";Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2";Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3";Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1";Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))";Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)";Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)";Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)";Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH";Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS";Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1";Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1";Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2";Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1";Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4";Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin";Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1";Reactome:R-HSA-9662786 "FURIN cleaves ADAM17";Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin";Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L";Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa";Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa";Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)";Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2";Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid";Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis";Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it";Reactome:R-HSA-9710106 "ELANE cleaves GSDMD";Reactome:R-HSA-9710263 "GZMB cleaves GSDME";Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b";Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage";Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion";Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b";Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b";Reactome:R-HSA-9816275 "CDH1 is proteolytically cleaved in Golgi";Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane";Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)";Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated";Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane";Reactome:R-HSA-9839367 "TGFBR3_mem cleavage by MMPs";Reactome:R-HSA-9911236 "ELANE cleaves NOTCH2NLA";Reactome:R-HSA-9911383 "LepB cleaves prepro-STa";Reactome:R-HSA-9912368 "LepB cleaves pre-EltA";Reactome:R-HSA-9912371 "LepB cleaves pre-EltB";Reactome:R-HSA-9913329 "Autoproteolysis of DAG1 to alpha and beta chains";Reactome:R-HSA-9918772 "Dengue polyprotein cis-auto-cleaves";Reactome:R-HSA-9918780 "Unknown peptidase cleaves NS1-NS2A";Reactome:R-HSA-9918787 "NS2B3 cleaves C-prM-E-NS1-NS2A";Reactome:R-HSA-9918795 "Signalase cleaves prM-E-NS1-NS2A";Reactome:R-HSA-9918813 "NS2B3 cleaves NS4AB";Reactome:R-HSA-9918817 "NS2B3 cleaves polyprotein";Reactome:R-HSA-9918823 "NS345:NS2B cleaves NS345";Reactome:R-HSA-9918871 "Signalase cleaves prepro-NS4B";Reactome:R-HSA-9918876 "NS2B3 cleaves prepro-C at the C-prM junction";Reactome:R-HSA-9919050 "Furin cleaves prM:E";Reactome:R-HSA-9921595 "NS2B3 cleaves FAM134B";Reactome:R-HSA-9921689 "NS3 cleaves GrpEL1";Reactome:R-HSA-9926936 "EspC(54-1018) cleaves hemoglobin";Reactome:R-HSA-9926963 "Hbp cis-autocleaves";Reactome:R-HSA-9927009 "Hbp(53-1100) cleaves hemoglobin";Reactome:R-HSA-9932162 "Removal of CDH1 signal peptide";Reactome:R-HSA-9947496 "ACOT2 cleaves NS345" molecular_function GO:0004300 enoyl-CoA hydratase activity xrefs EC:4.2.1.17;Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA";Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA";Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA";Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoA";Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O => (S)-3-Hydroxyhexadecanoyl-CoA";Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA";Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA";Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA";Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA";Reactome:R-HSA-9916717 "ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA";RHEA:20724 WAS EC:4.2.1.17;Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA";Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA";Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA";Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA";Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA";Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA";Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA";Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA";Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA";Reactome:R-HSA-9916717 "ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA";RHEA:20724 molecular_function GO:0004301 epoxide hydrolase activity xrefs EC:3.3.2.10;MetaCyc:3.3.2.10-RXN;Reactome:R-HSA-2161961 "5,6-EET is hydrolysed to 5,6-DHET by EPHX2";Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1";Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1";Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2";Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4";Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1";Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2";Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4";Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1";Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1";Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2";Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA";Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA";Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA";Reactome:R-HSA-9915968 "8,9-EET is hydrolysed to 8.9-DHET by EPHX2";Reactome:R-HSA-9915986 "11,12-EET is hydrolysed to 11,12-DHET by EPHX2";Reactome:R-HSA-9915994 "14,15-EET is hydrolysed to 14,15-DHET by EPHX2";RHEA:19037;RHEA:44032;RHEA:44036;RHEA:44040;RHEA:44044;RHEA:44048;RHEA:45352;RHEA:53972;RHEA:53976;RHEA:53980;RHEA:53984;RHEA:53992;RHEA:53996;RHEA:54000;RHEA:54004;RHEA:54008;RHEA:54012;RHEA:54016;RHEA:56584;RHEA:80591;RHEA:80779;RHEA:80783;RHEA:80787;RHEA:80791;RHEA:80795;RHEA:80799;RHEA:81855 WAS EC:3.3.2.10;MetaCyc:3.3.2.10-RXN;Reactome:R-HSA-2161961 "5,6-EET is hydrolysed to 5,6-DHET by EPHX2";Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1";Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1";Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2";Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4";Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1";Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2";Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4";Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1";Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1";Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2";Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA";Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA";Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA";Reactome:R-HSA-9915968 "8,9-EET is hydrolysed to 8.9-DHET by EPHX2";Reactome:R-HSA-9915986 "11,12-EET is hydrolysed to 11,12-DHET by EPHX2";Reactome:R-HSA-9915994 "14,15-EET is hydrolysed to 14,15-DHET by EPHX2";RHEA:19037;RHEA:44032;RHEA:44036;RHEA:44040;RHEA:44044;RHEA:44048;RHEA:45352;RHEA:56584;RHEA:80591;RHEA:80779;RHEA:80783;RHEA:80787;RHEA:80791;RHEA:80795;RHEA:80799;RHEA:81855 molecular_function GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity xrefs EC:1.1.5.3;MetaCyc:RXN-15745;Reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)";RHEA:18977;RHEA:28751;RHEA:28755;RHEA:29219;RHEA:29223 WAS EC:1.1.5.3;MetaCyc:RXN-15745;Reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)";RHEA:18977;RHEA:28755;RHEA:29219 molecular_function GO:0004407 histone deacetylase activity xrefs Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin";Reactome:R-HSA-2545253 "Deacetylation of cohesin";Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones";Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone";Reactome:R-HSA-3782637 "HDAC8 deacetylates histones";Reactome:R-HSA-3782655 "HDAC10 deacetylates histone";Reactome:R-HSA-427514 "eNoSC deacetylates histone H3";Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3";Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53";Reactome:R-HSA-9941704 "NuRD deacetylates telomeric nucleosomes";Reactome:R-HSA-9944092 "NuRD deacetylates nucleosomes" WAS Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin";Reactome:R-HSA-2545253 "Deacetylation of cohesin";Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones";Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone";Reactome:R-HSA-3782637 "HDAC8 deacetylates histones";Reactome:R-HSA-3782655 "HDAC10 deacetylates histone";Reactome:R-HSA-427514 "eNoSC deacetylates histone H3";Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3";Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53" molecular_function GO:0004483 methyltransferase cap1 activity xrefs EC:2.1.1.57;MetaCyc:2.1.1.57-RXN;Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs";Reactome:R-HSA-9923097 "NS5 acts as a cap 2'-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA";RHEA:19617;RHEA:60860;RHEA:60864;RHEA:67020 WAS EC:2.1.1.57;MetaCyc:2.1.1.57-RXN;Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs";Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs";Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";Reactome:R-HSA-9834003 "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs";Reactome:R-HSA-9923097 "NS5 acts as a cap 2'-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA";RHEA:67020 molecular_function GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity xrefs EC:1.2.1.27;MetaCyc:1.2.1.27-RXN;Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+";RHEA:20804;RHEA:76615;RHEA:76623;RHEA:76627 WAS EC:1.2.1.27;MetaCyc:1.2.1.27-RXN;Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+";RHEA:20804;RHEA:76615 molecular_function GO:0004497 monooxygenase activity xrefs Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde";Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO";Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone";Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA";Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation";Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2";Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA";Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole";Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide";Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST";Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA";Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM";Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL";Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation";Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6";Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation";Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole";Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO";Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4";Reactome:R-HSA-2161795 "Arachidonate is hydroxylated to 16-HETE by CYP(1)";Reactome:R-HSA-2161814 "Arachidonate is hydroxylated to 19-HETE by CYP(2)";Reactome:R-HSA-2161890 "Arachidonate is epoxidated to 5,6-EET by CYP(4)";Reactome:R-HSA-2161899 "Arachidonate is epoxidated to 8,9-EET by CYP(5)";Reactome:R-HSA-2161940 "Arachidonate is hydroxylated to 20-HETE by CYP(3)";Reactome:R-HSA-2162191 "Unknown enzyme hydroxylates DMPhOH";Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ";Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E";Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1";Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO";Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1";Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA";Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3";Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3";Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b";Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide";Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl";Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP";Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)";Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol";Reactome:R-HSA-76426 "N-atom dealkylation of caffeine";Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical";Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan";Reactome:R-HSA-76466 "CYP4A11 omega-hydroxylates DDCX";Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1";Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide";Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2";Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE";Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1";Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA";Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2";Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA";Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA";Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1";Reactome:R-HSA-9749986 "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA";Reactome:R-HSA-9750016 "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA";Reactome:R-HSA-9753285 "CYP2E1 monooxygenates APAP to NAPQI";Reactome:R-HSA-9756138 "CYP3A4 monooxygenates ATVL to 2-OH-ATVL";Reactome:R-HSA-9756162 "CYP3A4 monooxygenates ATV to 4-OH-ATV";Reactome:R-HSA-9756169 "CYP3A4 monooxygenates ATV to 2-OH-ATV";Reactome:R-HSA-9756180 "CYP3A4 monooxygenates ATVL to 4-OH-ATVL";Reactome:R-HSA-9915971 "Arachidonate is epoxidated to 11,12-EET by CYP(5)";Reactome:R-HSA-9915992 "Arachidonate is hydroxylated to 17-HETE by CYP(1)";Reactome:R-HSA-9915993 "Arachidonate is hydroxylated to 18-HETE by CYP(1)";Reactome:R-HSA-9915997 "Arachidonate is epoxidated to 14,15-EET by CYP(5)";Reactome:R-HSA-9971246 "Unknown CYP 450 omega-hydroxylates C10 fatty acid" WAS Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde";Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO";Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone";Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA";Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation";Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2";Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA";Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole";Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide";Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST";Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA";Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM";Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL";Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation";Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6";Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation";Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole";Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO";Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4";Reactome:R-HSA-2161795 "Arachidonate is hydroxylated to 16-HETE by CYP(1)";Reactome:R-HSA-2161814 "Arachidonate is hydroxylated to 19-HETE by CYP(2)";Reactome:R-HSA-2161890 "Arachidonate is epoxidated to 5,6-EET by CYP(4)";Reactome:R-HSA-2161899 "Arachidonate is epoxidated to 8,9-EET by CYP(5)";Reactome:R-HSA-2161940 "Arachidonate is hydroxylated to 20-HETE by CYP(3)";Reactome:R-HSA-2162191 "Unknown enzyme hydroxylates DMPhOH";Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ";Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E";Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1";Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO";Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1";Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA";Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3";Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3";Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b";Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide";Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl";Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP";Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)";Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol";Reactome:R-HSA-76426 "N-atom dealkylation of caffeine";Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical";Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan";Reactome:R-HSA-76466 "CYP4A11 omega-hydroxylates DDCX";Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1";Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide";Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2";Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE";Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1";Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA";Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2";Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA";Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA";Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1";Reactome:R-HSA-9749986 "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA";Reactome:R-HSA-9750016 "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA";Reactome:R-HSA-9753285 "CYP2E1 monooxygenates APAP to NAPQI";Reactome:R-HSA-9756138 "CYP3A4 monooxygenates ATVL to 2-OH-ATVL";Reactome:R-HSA-9756162 "CYP3A4 monooxygenates ATV to 4-OH-ATV";Reactome:R-HSA-9756169 "CYP3A4 monooxygenates ATV to 2-OH-ATV";Reactome:R-HSA-9756180 "CYP3A4 monooxygenates ATVL to 4-OH-ATVL";Reactome:R-HSA-9915971 "Arachidonate is epoxidated to 11,12-EET by CYP(5)";Reactome:R-HSA-9915992 "Arachidonate is hydroxylated to 17-HETE by CYP(1)";Reactome:R-HSA-9915993 "Arachidonate is hydroxylated to 18-HETE by CYP(1)";Reactome:R-HSA-9915997 "Arachidonate is epoxidated to 14,15-EET by CYP(5)" molecular_function GO:0004519 endonuclease activity xrefs Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more";Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch";Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER";Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends";Reactome:R-HSA-9970193 "CPSF3 cleaves pre-mRNA at distal 3'UTR PAS";Reactome:R-HSA-9970282 "U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS";Reactome:R-HSA-9970294 "CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS" WAS Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more";Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch";Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER";Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends";Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end";Reactome:R-HSA-9970193 "CPSF3 cleaves pre-mRNA at distal 3'UTR PAS";Reactome:R-HSA-9970282 "U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS";Reactome:R-HSA-9970294 "CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS" molecular_function GO:0004550 nucleoside diphosphate kinase activity xrefs EC:2.7.4.6;MetaCyc:NUCLEOSIDE-DIP-KIN-RXN;Reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP";Reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)";Reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)";Reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)";Reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)";Reactome:R-HSA-6806877 "NME1:NME3 heterohexamer phosphorylates NDPs to NTPs";Reactome:R-HSA-9605496 "NME6 phosphorylates (d)NDPs to (d)NTPs";Reactome:R-HSA-9748969 "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP";Reactome:R-HSA-9748999 "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP";Reactome:R-HSA-9755013 "NME1,2 hexamers phosphorylate RBV-DP" WAS EC:2.7.4.6;MetaCyc:NUCLEOSIDE-DIP-KIN-RXN;Reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP";Reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)";Reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)";Reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)";Reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)";Reactome:R-HSA-6806877 "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs";Reactome:R-HSA-9748969 "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP";Reactome:R-HSA-9748999 "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP";Reactome:R-HSA-9755013 "NME1,2 hexamers phosphorylate RBV-DP" molecular_function GO:0004596 protein-N-terminal amino-acid acetyltransferase activity xrefs EC:2.3.1.255;Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1";RHEA:21028;RHEA:50508;RHEA:50512;RHEA:50516;RHEA:57320;RHEA:57324;RHEA:57328;RHEA:75243;RHEA:75247 WAS EC:2.3.1.255;Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1";RHEA:21028;RHEA:50508;RHEA:50512;RHEA:50516;RHEA:57320;RHEA:75243;RHEA:75247 molecular_function GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity xrefs EC:2.3.1.43;MetaCyc:2.3.1.43-RXN;Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)";RHEA:21204;RHEA:34087;RHEA:53448;RHEA:53452;RHEA:53456;RHEA:53460;RHEA:53464;RHEA:53468;RHEA:53472;RHEA:53476;RHEA:53516;RHEA:53520 WAS EC:2.3.1.43;MetaCyc:2.3.1.43-RXN;Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)";RHEA:21204;RHEA:34087 molecular_function GO:0004623 A2-type glycerophospholipase activity xrefs EC:3.1.1.4;MetaCyc:PHOSPHOLIPASE-A2-RXN;MetaCyc:RXN-15065;MetaCyc:RXN-15067;Reactome:R-HSA-111881 "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase";Reactome:R-HSA-111883 "PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine";Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane";Reactome:R-HSA-8952251 "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)";RHEA:15801;RHEA:38779;RHEA:38847;RHEA:40427;RHEA:40519;RHEA:40643;RHEA:40651;RHEA:40811;RHEA:41223;RHEA:53500;RHEA:56428;RHEA:62036 WAS EC:3.1.1.4;MetaCyc:PHOSPHOLIPASE-A2-RXN;MetaCyc:RXN-15065;MetaCyc:RXN-15067;Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)";Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]";Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A";Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)";Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)";Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]";Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A";Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)";Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]";Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]";Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]";Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]";Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]";Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]";Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]";Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]";Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A";Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]";Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]";Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]";Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]";Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1";Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]";Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]";Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane";RHEA:15801 molecular_function GO:0004630 D-type glycerophospholipase activity xrefs EC:3.1.4.4;MetaCyc:PHOSCHOL-RXN;Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6";Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2";Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD";RHEA:14445;RHEA:41412;RHEA:41416 WAS EC:3.1.4.4;MetaCyc:PHOSCHOL-RXN;Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6";Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2";Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD";RHEA:14445 molecular_function GO:0004674 protein serine/threonine kinase activity xrefs EC:2.7.11.-;EC:2.7.11.1;EC:2.7.11.28;EC:2.7.11.29;EC:2.7.11.3;EC:2.7.11.9;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by AKT (PKB)";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK phosphorylates CDK1 bound to CCNB1";Reactome:R-HSA-170087 "CAK phosphorylates CDK1 bound to CCNA";Reactome:R-HSA-170116 "PKMYT1 phosphorylates CCNA:CDK1";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193703 "IKKbeta is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "mTORC2 phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202111 "AKT1 phosphorylates eNOS";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "mTORC2 phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of CDC25A by CHEK1";Reactome:R-HSA-69608 "Phosphorylation of CDC25A by CHEK2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412";Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9765960 "ERKs phosphorylate MCRIP1";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2";Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2";Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357";Reactome:R-HSA-9824582 "MAPK1 phosphorylates SOX10";Reactome:R-HSA-9824897 "p-S-TBK1 phosphorylates OPTN";Reactome:R-HSA-9824977 "MAPK1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824994 "RPS6KA1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824995 "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405";Reactome:R-HSA-9824999 "GSK3B phosphorylates p-S73 MITF-M at residue S69";Reactome:R-HSA-9825704 "AKT3 phosphorylates TBX3";Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P";Reactome:R-HSA-9831712 "M dimer is phosphorylated";Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated";Reactome:R-HSA-9834076 "PINK1 is autophosphorylated";Reactome:R-HSA-9834945 "PINK1 phosphorylates Ub on MOM proteins";Reactome:R-HSA-9835011 "PINK1 phosphorylates PRKN at S65";Reactome:R-HSA-9839363 "TGFBR3 phosphorylation by TGFBR2 complex";Reactome:R-HSA-9851972 "PLK1 phosphorylates FIRRM at S43";Reactome:R-HSA-9853369 "PLK1 phosphorylates FIRMM at S744";Reactome:R-HSA-9855910 "USF1 is phosphorylated by p-MAPK14";Reactome:R-HSA-9857661 "p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)";Reactome:R-HSA-9857673 "p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)";Reactome:R-HSA-9860292 "Activated IKBKB phosphorylates IRF5";Reactome:R-HSA-9860785 "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816";Reactome:R-HSA-9860800 "mTORC2 phosphorylates AKT1 on serine-473";Reactome:R-HSA-9861642 "NEK1 phosphorylates ME1";Reactome:R-HSA-9909369 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-9912396 "CDK5 phosphorylates CLOCK on serine-451 and serine-461";Reactome:R-HSA-9912401 "CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90";Reactome:R-HSA-9920673 "CDK5 phosphorylates PER2 on serine-396";Reactome:R-HSA-9922273 "CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene";Reactome:R-HSA-9926483 "MARK3 phosphorylates MITF-M on S173";Reactome:R-HSA-9929360 "GSK3B phosphorylates CD274";Reactome:R-HSA-9931292 "AMPK phosphorylates CD274";Reactome:R-HSA-9931409 "NEK2 phosphorylates CD274";Reactome:R-HSA-9931418 "CK2 phosphorylates CD274";Reactome:R-HSA-9933380 "Cytosolic tail of CDH1 is phosphorylated";Reactome:R-HSA-9942578 "Phosphorylation of CDC25A by p38 MAPK";Reactome:R-HSA-9943662 "CHEK1 phosphorylates NEK11";Reactome:R-HSA-9943675 "GSK3B phosphorylates CDC25A";Reactome:R-HSA-9943676 "NEK11 phosphorylates CDC25A";Reactome:R-HSA-9943678 "CHEK1 phosphorylates CHEK2-phosphorylated CDC25A";Reactome:R-HSA-9943687 "PLK3 phosphorylates CDC25A";Reactome:R-HSA-9943736 "Casein kinase I phosphorylates CDC25A";Reactome:R-HSA-9954237 "PIM1 phosphorylates GBP1";Reactome:R-HSA-9975250 "PGK1 phosphorylates AKT1S1" WAS EC:2.7.11.-;EC:2.7.11.1;EC:2.7.11.28;EC:2.7.11.29;EC:2.7.11.3;EC:2.7.11.9;MetaCyc:PROTEIN-KINASE-RXN;Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2";Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1";Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2";Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3";Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1";Reactome:R-HSA-111919 "PKA phosphorylates CREB1";Reactome:R-HSA-111970 "PKC phosphorylates GRK2";Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1";Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1";Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB";Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta";Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin";Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL";Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor";Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL";Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT";Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A";Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8";Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK";Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)";Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A";Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1";Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2";Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor";Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation";Reactome:R-HSA-156678 "Activation of Cdc25C";Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC";Reactome:R-HSA-156699 "Inactivation of Wee1 kinase";Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation";Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A";Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B";Reactome:R-HSA-162657 "Inactivation of Myt1 kinase";Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1";Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex";Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP";Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP";Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres";Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer";Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB";Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB";Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1";Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)";Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1";Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1";Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1";Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1";Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal";Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex";Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP";Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps";Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex";Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2";Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex";Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes";Reactome:R-HSA-170076 "CAK phosphorylates CDK1 bound to CCNB1";Reactome:R-HSA-170087 "CAK phosphorylates CDK1 bound to CCNA";Reactome:R-HSA-170116 "PKMYT1 phosphorylates CCNA:CDK1";Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain";Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor";Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1";Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1";Reactome:R-HSA-176116 "Recruitment and activation of Chk1";Reactome:R-HSA-176298 "Activation of claspin";Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3";Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2";Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2";Reactome:R-HSA-193647 "IRAK is activated";Reactome:R-HSA-193703 "IKKbeta is activated";Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate";Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex";Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3";Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3";Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3";Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha";Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308";Reactome:R-HSA-198347 "AKT phosphorylates BAD";Reactome:R-HSA-198371 "AKT phosphorylates GSK3";Reactome:R-HSA-198599 "AKT phosphorylates MDM2";Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it";Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha";Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-198621 "AKT phosphorylates caspase-9";Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473";Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1";Reactome:R-HSA-198731 "ERK1/2 activates ELK1";Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3";Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1";Reactome:R-HSA-199298 "AKT phosphorylates CREB1";Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors";Reactome:R-HSA-199839 "AKT can phosphorylate RSK";Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)";Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 119";Reactome:R-HSA-199910 "MSK1 activates ATF1";Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133";Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2";Reactome:R-HSA-199935 "MSK1 activates CREB";Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation";Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta";Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI";Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL";Reactome:R-HSA-202111 "AKT1 phosphorylates eNOS";Reactome:R-HSA-202222 "Phosphorylation of PKC theta";Reactome:R-HSA-202437 "Phosphorylation of CARMA1";Reactome:R-HSA-202459 "Phosphorylation of Bcl10";Reactome:R-HSA-202500 "Activation of IKK complex";Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex";Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB";Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4";Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)";Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2";Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)";Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3";Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1";Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)";Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)";Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2";Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N";Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N";Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N";Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N";Reactome:R-HSA-2029454 "Autophosphorylation of PAK1";Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1";Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI";Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1";Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase";Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A";Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197";Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop";Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19";Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9";Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1";Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex";Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant";Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex";Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1";Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD";Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3";Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1";Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2";Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it";Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9";Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)";Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors";Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1";Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK";Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)";Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2";Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA";Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms";Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin";Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits";Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN";Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation";Reactome:R-HSA-2730856 "Autophosphorylation of PAK";Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1";Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1";Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1";Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6";Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9";Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7";Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98";Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1";Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1";Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA";Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2";Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF";Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1";Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53";Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6";Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1";Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)";Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53";Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5";Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407";Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3";Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2";Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART";Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2";Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM";Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM";Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk";Reactome:R-HSA-3769394 "AKT phosphorylates CBY1";Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)";Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL";Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp";Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates";Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK";Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321";Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB";Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL";Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot";Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II";Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2";Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it";Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs";Reactome:R-HSA-3928620 "PAK1 autophosphorylates";Reactome:R-HSA-3928625 "PAKs autophosphorylate";Reactome:R-HSA-3928640 "PAKs phosphorylate MLC";Reactome:R-HSA-399939 "Autophosphorylation of PAK";Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5";Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1";Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta";Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK";Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS";Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1";Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK";Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK";Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK";Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1";Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha";Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2";Reactome:R-HSA-429714 "CSNK1G2 phosphorylates p-CERT1-2";Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding";Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation";Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2";Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT";Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF";Reactome:R-HSA-4411402 "Activation of NLK";Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)";Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs";Reactome:R-HSA-442832 "PAK phosphorylates cortactin";Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP";Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1";Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates";Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK";Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38";Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3";Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2";Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7";Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6";Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)";Reactome:R-HSA-450474 "MK2 phosphorylates BRF1";Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1";Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP";Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2";Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP";Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A";Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD";Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1";Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation";Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation";Reactome:R-HSA-5213464 "RIPK1 is phosphorylated";Reactome:R-HSA-5213466 "RIPK3 is phosphorylated";Reactome:R-HSA-5218814 "PAK2 autophorylates";Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC";Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732";Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21";Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL";Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27";Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB";Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex";Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5";Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates";Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin";Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418";Reactome:R-HSA-5578777 "DMPK phosphorylates PLN";Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer";Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB";Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates";Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta";Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2";Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3";Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2";Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3";Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit";Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338";Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3";Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer";Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer";Reactome:R-HSA-5635841 "GLI proteins are phosphorylated";Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI";Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)";Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores";Reactome:R-HSA-5668545 "NIK autophosphorylates on T559";Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)";Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase";Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK";Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA";Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A";Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs";Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated";Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1";Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1";Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1";Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs";Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer";Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1";Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1";Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF";Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1";Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1";Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM";Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer";Reactome:R-HSA-5682598 "ATM phosphorylates HERC2";Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1";Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs";Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates";Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1";Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4";Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8";Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8";Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs";Reactome:R-HSA-5685156 "ATR phosphorylates RPA2";Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51";Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2";Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1";Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C";Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4";Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3";Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5";Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3";Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1";Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs";Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1";Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN";Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs";Reactome:R-HSA-5692779 "p-T182 MAPKAPK5 phosphorylates FOXO1";Reactome:R-HSA-5693536 "ATM phosphorylates MDC1";Reactome:R-HSA-5693540 "MRN activates ATM";Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs";Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM";Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates";Reactome:R-HSA-5693598 "ATM phosphorylates NBN";Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15";Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23";Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA";Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1";Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2";Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1";Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2";Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53";Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420";Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53";Reactome:R-HSA-6799332 "ATR phosphorylates TP53";Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53";Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1";Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ";Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1";Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks";Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers";Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks";Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C";Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5";Reactome:R-HSA-6804276 "ATM phosphorylates TTC5";Reactome:R-HSA-6804955 "ATM phosphorylates MDM2";Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53";Reactome:R-HSA-6805103 "AURKA phosphorylates TP53";Reactome:R-HSA-6805126 "AURKB phosphorylates TP53";Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53";Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53";Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53";Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53";Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A";Reactome:R-HSA-6805785 "AKT phosphorylates PHF20";Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter";Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A";Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL";Reactome:R-HSA-69604 "Phosphorylation of CDC25A by CHEK1";Reactome:R-HSA-69608 "Phosphorylation of CDC25A by CHEK2";Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53";Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM";Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1";Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1";Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2";Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta";Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD";Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN";Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends";Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1";Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation";Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1";Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer";Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156";Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B";Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C";Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A";Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23";Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3";Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2";Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1";Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A";Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1";Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2";Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN";Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3";Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10";Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3";Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B";Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300";Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1";Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2";Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling";Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2";Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1";Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6";Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1";Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2";Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17";Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1";Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates";Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6";Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2";Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2";Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2";Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD";Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex";Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2";Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423";Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3";Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2";Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions";Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2";Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7";Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";Reactome:R-HSA-933525 "Phosphorylation and release of IRF7";Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1";Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex";Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP";Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex";Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4";Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF";Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF";Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF";Reactome:R-HSA-9612501 "SGK phosphorylates CREB1";Reactome:R-HSA-9612509 "SGK phosphorylates SRF";Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates";Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs";Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT";Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs";Reactome:R-HSA-9620004 "RSKs autophosphorylate";Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR";Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345";Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T412";Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation";Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen";Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1";Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates";Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2";Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA";Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4";Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates";Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)";Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs";Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181";Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants";Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer";Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17";Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL";Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein";Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3";Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172";Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE";Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner";Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein";Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein";Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein";Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3";Reactome:R-HSA-9734547 "JAK2-activated MAPKs phosphorylate YBX1";Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9";Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88;Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9";Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9";Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b";Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR";Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex";Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88";Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex";Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR";Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2";Reactome:R-HSA-9765960 "ERKs phosphorylate MCRIP1";Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated";Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4";Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor";Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2";Reactome:R-HSA-9796067 "PRKAA2 phosphorylates nuclear NFE2L2";Reactome:R-HSA-9796081 "EIF2AK3 phosphorylates NFE2L2";Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320";Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189";Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25";Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357";Reactome:R-HSA-9824582 "MAPK1 phosphorylates SOX10";Reactome:R-HSA-9824897 "p-S-TBK1 phosphorylates OPTN";Reactome:R-HSA-9824977 "MAPK1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824994 "RPS6KA1-dependent phosphorylation of MITF-M";Reactome:R-HSA-9824995 "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405";Reactome:R-HSA-9824999 "GSK3B phosphorylates p-S73 MITF-M at residue S69";Reactome:R-HSA-9825704 "AKT3 phosphorylates TBX3";Reactome:R-HSA-9831514 "CK2 phosphorylates nascent P";Reactome:R-HSA-9831712 "M dimer is phosphorylated";Reactome:R-HSA-9832782 "p-S232-S237-P is further phosphorylated";Reactome:R-HSA-9834076 "PINK1 is autophosphorylated";Reactome:R-HSA-9834945 "PINK1 phosphorylates Ub on MOM proteins";Reactome:R-HSA-9835011 "PINK1 phosphorylates PRKN at S65";Reactome:R-HSA-9839363 "TGFBR3 phosphorylation by TGFBR2 complex";Reactome:R-HSA-9851972 "PLK1 phosphorylates FIRRM at S43";Reactome:R-HSA-9853369 "PLK1 phosphorylates FIRMM at S744";Reactome:R-HSA-9855910 "USF1 is phosphorylated by p-MAPK14";Reactome:R-HSA-9857661 "p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)";Reactome:R-HSA-9857673 "p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)";Reactome:R-HSA-9860292 "Activated IKBKB phosphorylates IRF5";Reactome:R-HSA-9860785 "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816";Reactome:R-HSA-9860800 "mTORC2 phosphorylates AKT1 on serine-473";Reactome:R-HSA-9861642 "NEK1 phosphorylates ME1";Reactome:R-HSA-9909369 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins";Reactome:R-HSA-9912396 "CDK5 phosphorylates CLOCK on serine-451 and serine-461";Reactome:R-HSA-9912401 "CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90";Reactome:R-HSA-9920673 "CDK5 phosphorylates PER2 on serine-396";Reactome:R-HSA-9922273 "CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene";Reactome:R-HSA-9926483 "MARK3 phosphorylates MITF-M on S173";Reactome:R-HSA-9929360 "GSK3B phosphorylates CD274";Reactome:R-HSA-9931292 "AMPK phosphorylates CD274";Reactome:R-HSA-9931409 "NEK2 phosphorylates CD274";Reactome:R-HSA-9931418 "CK2 phosphorylates CD274";Reactome:R-HSA-9933380 "Cytosolic tail of CDH1 is phosphorylated";Reactome:R-HSA-9942578 "Phosphorylation of CDC25A by p38 MAPK";Reactome:R-HSA-9943662 "CHEK1 phosphorylates NEK11";Reactome:R-HSA-9943675 "GSK3B phosphorylates CDC25A";Reactome:R-HSA-9943676 "NEK11 phosphorylates CDC25A";Reactome:R-HSA-9943678 "CHEK1 phosphorylates CHEK2-phosphorylated CDC25A";Reactome:R-HSA-9943687 "PLK3 phosphorylates CDC25A";Reactome:R-HSA-9943736 "Casein kinase I phosphorylates CDC25A";Reactome:R-HSA-9954237 "PIM1 phosphorylates GBP1" molecular_function GO:0004713 protein tyrosine kinase activity xrefs EC:2.7.10.-;MetaCyc:2.7.10.1-RXN;Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1";Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma";Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation";Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers";Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers";Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer";Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers";Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers";Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers";Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2";Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5";Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227";Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4";Reactome:R-HSA-1433418 "Phosphorylation of JAK2";Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs";Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs";Reactome:R-HSA-1433506 "Phosphorylation of APS";Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1";Reactome:R-HSA-1470009 "Phosphorylation of STATs";Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases";Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR";Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated";Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes";Reactome:R-HSA-170156 "WEE1 phosphorylates CCNA:CDK1";Reactome:R-HSA-170991 "SRC-1 autophosphorylates";Reactome:R-HSA-171011 "Binding and activation of MAP Kinase";Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15";Reactome:R-HSA-177934 "EGFR autophosphorylation";Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase";Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)";Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)";Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers";Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1";Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1";Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2";Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions";Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors";Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3";Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4";Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b";Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c";Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b";Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c";Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b";Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c";Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c";Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src";Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers";Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers";Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2";Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1";Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant";Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants";Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant";Reactome:R-HSA-201521 "ALK autophosphorylation";Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes";Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck";Reactome:R-HSA-202174 "Activation of ZAP-70";Reactome:R-HSA-202216 "Phosphorylation of SLP-76";Reactome:R-HSA-202233 "Inactivation of Lck by Csk";Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT";Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1";Reactome:R-HSA-202291 "Activation of Lck";Reactome:R-HSA-202307 "Change of PKC theta conformation";Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers";Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity";Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG";Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases";Reactome:R-HSA-2029453 "Phosphorylation of VAV";Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts";Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants";Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants";Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity";Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding";Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding";Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity";Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants";Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity";Reactome:R-HSA-205289 "Autophosphorylation of KIT";Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src";Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2";Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation";Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs";Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP";Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK";Reactome:R-HSA-2395412 "Phosphorylation of SYK";Reactome:R-HSA-2395439 "Phosphorylation of DAP12";Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1";Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates";Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK";Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK";Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK";Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4";Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN";Reactome:R-HSA-2454239 "Phosphorylation of SYK";Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR";Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin";Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin";Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin";Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin";Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK";Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK";Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN";Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase";Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta";Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn";Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase";Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma";Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F";Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397";Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC";Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex";Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN";Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2";Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn";Reactome:R-HSA-377640 "Autophosphorylation of SRC";Reactome:R-HSA-380780 "Activation of Src";Reactome:R-HSA-388831 "Phosphorylation of CD28";Reactome:R-HSA-388833 "Phosphorylation of CTLA-4";Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors";Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors";Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues";Reactome:R-HSA-389354 "Activation of Vav1";Reactome:R-HSA-389762 "Phosphorylation of PD-1";Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha";Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts";Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase";Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn";Reactome:R-HSA-3928578 "EPH receptors autophosphorylate";Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs";Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B";Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1";Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3";Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397";Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1";Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF";Reactome:R-HSA-399934 "Phosphorylation of Plexin-A";Reactome:R-HSA-399946 "Recruitment and activation of Cdk5";Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes";Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2";Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)";Reactome:R-HSA-418859 "Phosphorylation of Unc5C";Reactome:R-HSA-418872 "Phosphorylation of FADK1";Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met";Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase";Reactome:R-HSA-429441 "SYK activation by SRC";Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation";Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8";Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT";Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates";Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1";Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB";Reactome:R-HSA-4420206 "Phosphorylation of SRC-1";Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2";Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1";Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC";Reactome:R-HSA-445085 "Phosphorylation of VAV2";Reactome:R-HSA-445091 "Phosphorylation of Neurofascin";Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1";Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated";Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated";Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB";Reactome:R-HSA-508282 "SYK is a substrate for JAK1";Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2";Reactome:R-HSA-5218642 "PTK2 autophosphorylates";Reactome:R-HSA-5218806 "FYN autophosphorylates";Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118";Reactome:R-HSA-5218812 "FYN phosphorylates PAK2";Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV";Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1";Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta";Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407";Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821";Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG";Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan";Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG";Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2";Reactome:R-HSA-5621370 "SYK autophosphorylates";Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341";Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant";Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII";Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1";Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1";Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1";Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1";Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2";Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1";Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2";Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2";Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1";Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c";Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2";Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3";Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1";Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11";Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3";Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11";Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3";Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11";Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1";Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3";Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11";Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1";Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2";Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2";Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2";Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2";Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1";Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1";Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142";Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52";Reactome:R-HSA-5690702 "LYN phosphorylates CD22";Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2";Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2";Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation";Reactome:R-HSA-6806974 "MET dimers autophosphorylate";Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK";Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1";Reactome:R-HSA-873918 "Transphosphorylation of JAK1";Reactome:R-HSA-873919 "Phosphorylation of JAK2";Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases";Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases";Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor";Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2";Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated";Reactome:R-HSA-8847977 "FRK phosphorylates PTEN";Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation";Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2";Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3";Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B";Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN";Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1";Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1";Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1";Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL";Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1";Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1";Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2";Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3";Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35";Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6";Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ";Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2";Reactome:R-HSA-8851933 "MET phosphorylates GAB1";Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions";Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate";Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate";Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1";Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB";Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation";Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6";Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307";Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15";Reactome:R-HSA-8874078 "PTK2 autophosphorylates";Reactome:R-HSA-8874080 "SRC phosphorylates PTK2";Reactome:R-HSA-8874082 "MET phosphorylates PTK2";Reactome:R-HSA-8875451 "MET phosphorylates CBL";Reactome:R-HSA-8875817 "MET phosphorylates STAT3";Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates";Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL";Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1";Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1";Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3";Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1";Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes";Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18";Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1";Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4";Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR";Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin";Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1";Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2";Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3";Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates";Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1";Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1";Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1";Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2";Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1";Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2";Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2";Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1";Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1";Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3";Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates";Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B";Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5";Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation";Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate";Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1";Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1";Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2";Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer";Reactome:R-HSA-909726 "Phosphorylation of STAT1";Reactome:R-HSA-909729 "Activation of JAK kinases";Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2";Reactome:R-HSA-909732 "Phosphorylation of STAT2";Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated";Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation";Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates";Reactome:R-HSA-9606159 "BTK autophosphorylates";Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2";Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK";Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs";Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates";Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates";Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1";Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR";Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1";Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK";Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers";Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect";Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate";Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1";Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate";Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1";Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate";Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3";Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants";Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants";Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants";Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants";Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers";Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins";Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB";Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1";Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2";Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants";Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants";Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2";Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5";Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B";Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2";Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1";Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1";Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1";Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions";Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK";Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1";Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC";Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3";Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate";Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2";Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10";Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL";Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3";Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1";Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3";Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1";Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS";Reactome:R-HSA-9726848 "SRC phosphorylates RHOU";Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1";Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561";Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL";Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483";Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR";Reactome:R-HSA-9831136 "SH pentamer is phosphorylated";Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)";Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR";Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)";Reactome:R-HSA-9841924 "ABL1 phosphorylates PPARG2";Reactome:R-HSA-9842648 "Autophosphorylation of LTK dimer:ALKAL1,2";Reactome:R-HSA-9842651 "Active LTK receptor phosphorylates SHC1";Reactome:R-HSA-9842666 "Active LTK phosphorylates IRS1";Reactome:R-HSA-9842667 "CLIP1-LTK fusion autophosphorylates";Reactome:R-HSA-9860500 "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1";Reactome:R-HSA-9860759 "p-T816-PKN2 phosphorylates AKT1 on serine-308";Reactome:R-HSA-9861469 "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)";Reactome:R-HSA-9865196 "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1";Reactome:R-HSA-9931290 "IL6-activated JAK1 phosphorylates CD274";Reactome:R-HSA-9934751 "CDH1 is phosphorylated on tyrosine residues";Reactome:R-HSA-9958871 "Tyrosine phosphorylation of STAT3 by IL6 receptor";Reactome:R-HSA-9958889 "SRC phosphorylates CDH1";Reactome:R-HSA-9958892 "SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs";RHEA:10596 WAS EC:2.7.10.-;MetaCyc:2.7.10.1-RXN;Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1";Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma";Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation";Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers";Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants";Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers";Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer";Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers";Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers";Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers";Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2";Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5";Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227";Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4";Reactome:R-HSA-1433418 "Phosphorylation of JAK2";Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs";Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs";Reactome:R-HSA-1433506 "Phosphorylation of APS";Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1";Reactome:R-HSA-1470009 "Phosphorylation of STATs";Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases";Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR";Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated";Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes";Reactome:R-HSA-170156 "WEE1 phosphorylates CCNA:CDK1";Reactome:R-HSA-170991 "SRC-1 autophosphorylates";Reactome:R-HSA-171011 "Binding and activation of MAP Kinase";Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15";Reactome:R-HSA-177934 "EGFR autophosphorylation";Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase";Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)";Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)";Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers";Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1";Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1";Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2";Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions";Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors";Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3";Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4";Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b";Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c";Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b";Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c";Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b";Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c";Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c";Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src";Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers";Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers";Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2";Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1";Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant";Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants";Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant";Reactome:R-HSA-201521 "ALK autophosphorylation";Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes";Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck";Reactome:R-HSA-202174 "Activation of ZAP-70";Reactome:R-HSA-202216 "Phosphorylation of SLP-76";Reactome:R-HSA-202233 "Inactivation of Lck by Csk";Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT";Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1";Reactome:R-HSA-202291 "Activation of Lck";Reactome:R-HSA-202307 "Change of PKC theta conformation";Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers";Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity";Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG";Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases";Reactome:R-HSA-2029453 "Phosphorylation of VAV";Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts";Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants";Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants";Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity";Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding";Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding";Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity";Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants";Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity";Reactome:R-HSA-205289 "Autophosphorylation of KIT";Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src";Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2";Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation";Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs";Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP";Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK";Reactome:R-HSA-2395412 "Phosphorylation of SYK";Reactome:R-HSA-2395439 "Phosphorylation of DAP12";Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1";Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates";Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK";Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK";Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK";Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4";Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN";Reactome:R-HSA-2454239 "Phosphorylation of SYK";Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR";Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin";Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin";Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin";Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin";Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK";Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK";Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK";Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK";Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN";Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase";Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta";Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn";Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase";Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma";Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F";Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397";Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC";Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex";Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN";Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2";Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn";Reactome:R-HSA-377640 "Autophosphorylation of SRC";Reactome:R-HSA-380780 "Activation of Src";Reactome:R-HSA-388831 "Phosphorylation of CD28";Reactome:R-HSA-388833 "Phosphorylation of CTLA-4";Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors";Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors";Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues";Reactome:R-HSA-389354 "Activation of Vav1";Reactome:R-HSA-389762 "Phosphorylation of PD-1";Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha";Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts";Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase";Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn";Reactome:R-HSA-3928578 "EPH receptors autophosphorylate";Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs";Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B";Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1";Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3";Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397";Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1";Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF";Reactome:R-HSA-399934 "Phosphorylation of Plexin-A";Reactome:R-HSA-399946 "Recruitment and activation of Cdk5";Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes";Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2";Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)";Reactome:R-HSA-418859 "Phosphorylation of Unc5C";Reactome:R-HSA-418872 "Phosphorylation of FADK1";Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met";Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase";Reactome:R-HSA-429441 "SYK activation by SRC";Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation";Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8";Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT";Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates";Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1";Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB";Reactome:R-HSA-4420206 "Phosphorylation of SRC-1";Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2";Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1";Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC";Reactome:R-HSA-445085 "Phosphorylation of VAV2";Reactome:R-HSA-445091 "Phosphorylation of Neurofascin";Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1";Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated";Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated";Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB";Reactome:R-HSA-508282 "SYK is a substrate for JAK1";Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2";Reactome:R-HSA-5218642 "PTK2 autophosphorylates";Reactome:R-HSA-5218806 "FYN autophosphorylates";Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118";Reactome:R-HSA-5218812 "FYN phosphorylates PAK2";Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV";Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1";Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta";Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407";Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821";Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG";Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan";Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG";Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2";Reactome:R-HSA-5621370 "SYK autophosphorylates";Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341";Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant";Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII";Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1";Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1";Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1";Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1";Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2";Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1";Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2";Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2";Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1";Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c";Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2";Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3";Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1";Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11";Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3";Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11";Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3";Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11";Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1";Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3";Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11";Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1";Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2";Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2";Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2";Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2";Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1";Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1";Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142";Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52";Reactome:R-HSA-5690702 "LYN phosphorylates CD22";Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2";Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2";Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation";Reactome:R-HSA-6806974 "MET dimers autophosphorylate";Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK";Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1";Reactome:R-HSA-873918 "Transphosphorylation of JAK1";Reactome:R-HSA-873919 "Phosphorylation of JAK2";Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases";Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases";Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor";Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2";Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated";Reactome:R-HSA-8847977 "FRK phosphorylates PTEN";Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation";Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2";Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3";Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B";Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN";Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1";Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1";Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1";Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL";Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1";Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1";Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2";Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3";Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35";Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6";Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ";Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2";Reactome:R-HSA-8851933 "MET phosphorylates GAB1";Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions";Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate";Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate";Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1";Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB";Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation";Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6";Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307";Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15";Reactome:R-HSA-8874078 "PTK2 autophosphorylates";Reactome:R-HSA-8874080 "SRC phosphorylates PTK2";Reactome:R-HSA-8874082 "MET phosphorylates PTK2";Reactome:R-HSA-8875451 "MET phosphorylates CBL";Reactome:R-HSA-8875817 "MET phosphorylates STAT3";Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates";Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL";Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1";Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1";Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3";Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1";Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes";Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18";Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1";Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC";Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4";Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR";Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin";Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1";Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2";Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3";Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates";Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1";Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate";Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1";Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1";Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2";Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1";Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2";Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2";Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1";Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1";Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3";Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates";Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B";Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5";Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation";Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate";Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1";Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1";Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2";Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer";Reactome:R-HSA-909726 "Phosphorylation of STAT1";Reactome:R-HSA-909729 "Activation of JAK kinases";Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2";Reactome:R-HSA-909732 "Phosphorylation of STAT2";Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated";Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation";Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates";Reactome:R-HSA-9606159 "BTK autophosphorylates";Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2";Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK";Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs";Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates";Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates";Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1";Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR";Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1";Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK";Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers";Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect";Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate";Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1";Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate";Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1";Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1";Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate";Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3";Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants";Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants";Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants";Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants";Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers";Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins";Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB";Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1";Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2";Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants";Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants";Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2";Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5";Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B";Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2";Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1";Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1";Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1";Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions";Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK";Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1";Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC";Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3";Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate";Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2";Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10";Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL";Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3";Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1";Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3";Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1";Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS";Reactome:R-HSA-9726848 "SRC phosphorylates RHOU";Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1";Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561";Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL";Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483";Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR";Reactome:R-HSA-9831136 "SH pentamer is phosphorylated";Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)";Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR";Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)";Reactome:R-HSA-9841924 "ABL1 phosphorylates PPARG2";Reactome:R-HSA-9842648 "Autophosphorylation of LTK dimer:ALKAL1,2";Reactome:R-HSA-9842651 "Active LTK receptor phosphorylates SHC1";Reactome:R-HSA-9842666 "Active LTK phosphorylates IRS1";Reactome:R-HSA-9842667 "CLIP1-LTK fusion autophosphorylates";Reactome:R-HSA-9860500 "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1";Reactome:R-HSA-9860759 "p-T816-PKN2 phosphorylates AKT1 on serine-308";Reactome:R-HSA-9861469 "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)";Reactome:R-HSA-9865196 "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1";Reactome:R-HSA-9931290 "IL6-activated JAK1 phosphorylates CD274";Reactome:R-HSA-9934751 "CDH1 is phosphorylated on tyrosine residues";RHEA:10596 molecular_function GO:0004722 protein serine/threonine phosphatase activity xrefs EC:3.1.3.16;MetaCyc:3.1.3.16-RXN;Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";Reactome:R-HSA-163689 "PP2A complex dephosphorylates pChREBP (MLXIPL)";Reactome:R-HSA-163750 "PP2A complex dephosphorylates pPFKFB1";Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";Reactome:R-HSA-380949 "AMPK is dephosphorylated";Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2";Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1";Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs";Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex";Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs";Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2";Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1";Reactome:R-HSA-9853385 "PPP1CC dephosphorylates PLK1";Reactome:R-HSA-9861725 "PGAM5 dodecamer dephosphorylates p-S336-ME1";Reactome:R-HSA-9865226 "PP2A dephosphorylates serine-127 of YAP1";Reactome:R-HSA-9865238 "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin";Reactome:R-HSA-9912527 "H139Hfs13* PPM1K does not dephosphorylate BCKDH";Reactome:R-HSA-9970190 "PP1 dephosphorylates RNA Pol II";RHEA:12849;RHEA:20629;RHEA:47004;RHEA:53988 WAS EC:3.1.3.16;MetaCyc:3.1.3.16-RXN;Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2";Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate";Reactome:R-HSA-163689 "PP2A complex dephosphorylates pChREBP (MLXIPL)";Reactome:R-HSA-163750 "PP2A complex dephosphorylates pPFKFB1";Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin";Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT";Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A";Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34";Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A";Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3";Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3";Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1";Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1";Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex";Reactome:R-HSA-380949 "AMPK is dephosphorylated";Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1";Reactome:R-HSA-429730 "PPM1L dephosphorylates multiphospho-CERT1-2";Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN";Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1";Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs";Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1";Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338";Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P";Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1";Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2";Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6";Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24";Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2";Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma";Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO";Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5";Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4";Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII";Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1";Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs";Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex";Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs";Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2";Reactome:R-HSA-9831948 "P:PP1 dephosphorylates M2-1";Reactome:R-HSA-9853385 "PPP1CC dephosphorylates PLK1";Reactome:R-HSA-9861725 "PGAM5 dodecamer dephosphorylates p-S336-ME1";Reactome:R-HSA-9865226 "PP2A dephosphorylates serine-127 of YAP1";Reactome:R-HSA-9865238 "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin";Reactome:R-HSA-9912527 "H139Hfs13* PPM1K does not dephosphorylate BCKDH";Reactome:R-HSA-9970190 "PP1 dephosphorylates RNA Pol II";RHEA:20629;RHEA:47004 molecular_function GO:0004731 purine-nucleoside phosphorylase activity xrefs EC:2.4.2.1;MetaCyc:PNP-RXN;Reactome:R-HSA-112033 "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine";Reactome:R-HSA-112034 "PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine";Reactome:R-HSA-74242 "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose";Reactome:R-HSA-74249 "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose";Reactome:R-HSA-9735775 "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose";Reactome:R-HSA-9735789 "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose";Reactome:R-HSA-9755044 "PNP trimer transforms RBV to T-CONH2";RHEA:19805;RHEA:27638;RHEA:27642;RHEA:27646 WAS EC:2.4.2.1;MetaCyc:PNP-RXN;Reactome:R-HSA-112033 "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine";Reactome:R-HSA-112034 "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine";Reactome:R-HSA-74242 "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose";Reactome:R-HSA-74249 "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose";Reactome:R-HSA-9735775 "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose";Reactome:R-HSA-9735789 "Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose";Reactome:R-HSA-9755044 "PNP trimer transforms RBV to T-CONH2";RHEA:19805;RHEA:27638;RHEA:27642;RHEA:27646 molecular_function GO:0004767 sphingomyelin phosphodiesterase activity xrefs EC:3.1.4.12;KEGG_REACTION:R02541;MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN;Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM";Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)";Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)";Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin";Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets";Reactome:R-HSA-9769742 "SMPD1 converts sphingomyelin to ceramide";RHEA:19253;RHEA:45324;RHEA:54284 WAS EC:3.1.4.12;KEGG_REACTION:R02541;MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN;Reactome:R-HSA-1605797 "SMPD1 hydrolyzes SPHM";Reactome:R-HSA-1606273 "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)";Reactome:R-HSA-1606288 "SMPD4 hydrolyzes sphingomyelin (ER membrane)";Reactome:R-HSA-1640164 "ENPP7 hydrolyzes sphingomyelin";Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets";RHEA:19253;RHEA:45324;RHEA:54284 molecular_function GO:0004771 sterol ester esterase activity xrefs EC:3.1.1.13;MetaCyc:STEROL-ESTERASE-RXN;Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters";Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids";RHEA:10100;RHEA:33543;RHEA:33547;RHEA:33875;RHEA:36403 WAS EC:3.1.1.13;MetaCyc:STEROL-ESTERASE-RXN;Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters";Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids";RHEA:10100;RHEA:33543;RHEA:33547;RHEA:36403 molecular_function GO:0004791 thioredoxin-disulfide reductase (NADPH) activity xrefs EC:1.8.1.9;KEGG_REACTION:R02016;MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN;Reactome:R-HSA-1222485 "TrxB reactivates TrxA";Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH";Reactome:R-HSA-73646 "Regeneration of active (reduced) Thioredoxin";Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300";RHEA:20345 WAS EC:1.8.1.9;KEGG_REACTION:R02016;MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN;Reactome:R-HSA-1222485 "TrxB reactivates TrxA";Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH";Reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+";Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300";RHEA:20345 molecular_function GO:0004799 thymidylate synthase activity xrefs EC:2.1.1.45;KEGG_REACTION:R02101;MetaCyc:THYMIDYLATESYN-RXN;Reactome:R-HSA-73605 "conversion of dUMP to dTMP";RHEA:12104 WAS EC:2.1.1.45;KEGG_REACTION:R02101;MetaCyc:THYMIDYLATESYN-RXN;Reactome:R-HSA-73605 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate";RHEA:12104 molecular_function GO:0004806 triacylglycerol lipase activity xrefs EC:3.1.1.3;MetaCyc:RXN-19278;Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3";Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid";Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA";Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG";Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG";RHEA:12044;RHEA:33271;RHEA:35667;RHEA:38379;RHEA:38387;RHEA:38391;RHEA:38395;RHEA:38399;RHEA:38403;RHEA:38407;RHEA:38411;RHEA:38415;RHEA:38419;RHEA:38423;RHEA:38427;RHEA:38431;RHEA:38495;RHEA:38499;RHEA:38575;RHEA:39931;RHEA:40047;RHEA:40055;RHEA:40475;RHEA:40627;RHEA:43732;RHEA:44864;RHEA:47864;RHEA:48024;RHEA:48028;RHEA:59020;RHEA:59024;RHEA:63432;RHEA:63436 WAS EC:3.1.1.3;MetaCyc:RXN-19278;Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3";Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid";Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA";Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG";Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG";RHEA:12044;RHEA:35667;RHEA:38495;RHEA:38575;RHEA:40475;RHEA:47864;RHEA:48024;RHEA:48028;RHEA:59020;RHEA:59024 molecular_function GO:0004842 ubiquitin-protein transferase activity xrefs KEGG_REACTION:R03876;Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha";Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha";Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH";Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41";Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3";Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3";Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)";Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2";Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling";Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1";Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex";Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP";Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex";Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-179417 "Multiubiquitination of Nek2A";Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G";Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex";Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85";Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)";Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty";Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix";Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty";Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7";Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21";Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX";Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand";Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2";Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2";Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer";Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1";Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination";Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling";Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6";Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF";Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex";Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34";Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7";Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2";Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3";Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2";Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7";Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3";Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3";Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )";Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels";Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants";Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants";Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants";Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA";Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56";Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21";Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1";Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2";Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1";Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2";Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)";Reactome:R-HSA-4332236 "CBL neddylates TGFBR2";Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated";Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation";Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1";Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1";Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments";Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated";Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP";Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex";Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates";Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1";Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1";Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2";Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3";Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA";Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH";Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA";Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP";Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP";Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3";Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK";Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated";Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2";Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2";Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains";Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1";Reactome:R-HSA-69598 "Ubiquitination of phosphorylated CDC25A";Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO";Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1";Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4";Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3";Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha";Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3";Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex";Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated";Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS";Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2";Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains";Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation";Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation";Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer";Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363";Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates";Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5";Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex";Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane";Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6";Reactome:R-HSA-9766227 "MDM2 mediates CDH1 ubiquitination";Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50";Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3";Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627";Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634";Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627";Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR";Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530";Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex";Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2";Reactome:R-HSA-983153 "E1 mediated ubiquitin activation";Reactome:R-HSA-983156 "Polyubiquitination of substrate";Reactome:R-HSA-9833155 "Ubiquitination of STAT2";Reactome:R-HSA-9834070 "PRKN ubiquitinates MOM substrates";Reactome:R-HSA-9861563 "CTLH E3 ligase ubiquitinates LDHA";Reactome:R-HSA-9861640 "CTLH E3 ligase ubiquitinates PKM-1";Reactome:R-HSA-9929350 "Ubiquitination of CD274 by BTRC-SCF E3-ligase complex";Reactome:R-HSA-9934753 "CBLL1 ubiquitinates CDH1";Reactome:R-HSA-9948301 "ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit";Reactome:R-HSA-9954721 "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide";Reactome:R-HSA-9955146 "S.flexneri ipaH9.8 ubiquitinates GBPs";Reactome:R-HSA-9958873 "Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination";Reactome:R-HSA-9970191 "RBBP6 activates CPSF complex" WAS KEGG_REACTION:R03876;Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha";Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha";Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH";Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41";Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3";Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3";Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)";Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2";Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling";Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1";Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex";Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP";Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex";Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex";Reactome:R-HSA-179417 "Multiubiquitination of Nek2A";Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G";Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex";Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85";Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)";Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty";Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix";Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty";Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7";Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21";Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX";Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand";Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2";Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2";Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer";Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1";Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination";Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling";Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6";Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF";Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex";Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34";Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7";Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2";Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3";Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2";Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7";Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3";Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3";Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )";Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels";Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6";Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants";Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants";Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants";Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA";Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56";Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21";Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1";Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2";Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1";Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2";Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)";Reactome:R-HSA-4332236 "CBL neddylates TGFBR2";Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated";Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation";Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1";Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1";Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments";Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated";Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP";Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex";Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates";Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1";Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1";Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2";Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3";Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA";Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH";Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA";Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP";Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP";Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3";Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK";Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated";Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2";Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2";Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains";Reactome:R-HSA-68712 "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1";Reactome:R-HSA-69598 "Ubiquitination of phosphorylated CDC25A";Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO";Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1";Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4";Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3";Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha";Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3";Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex";Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex";Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated";Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS";Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2";Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains";Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation";Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation";Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer";Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363";Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates";Reactome:R-HSA-9750946 "TRAF2,6 ubiquitinates NLRC5";Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex";Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane";Reactome:R-HSA-9758604 "Ubiquitination of IKBKG by TRAF6";Reactome:R-HSA-9766227 "MDM2 mediates CDH1 ubiquitination";Reactome:R-HSA-9793444 "ITCH polyubiquitinates MLKL at K50";Reactome:R-HSA-9793485 "PRKN polyubiquitinates RIPK3";Reactome:R-HSA-9793679 "LUBAC ubiquitinates RIPK1 at K627";Reactome:R-HSA-9796346 "MIB2 ubiquitinates RIPK1 at K377, K604, K634";Reactome:R-HSA-9796387 "STUB1 ubiquitinates RIPK1 at K571, K604, K627";Reactome:R-HSA-9796626 "MIB2 ubiquitinates CFLAR";Reactome:R-HSA-9815507 "MIB2 ubiquitinates CYLD at K338, K530";Reactome:R-HSA-9817362 "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex";Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2";Reactome:R-HSA-983153 "E1 mediated ubiquitin activation";Reactome:R-HSA-983156 "Polyubiquitination of substrate";Reactome:R-HSA-9833155 "Ubiquitination of STAT2";Reactome:R-HSA-9834070 "PRKN ubiquitinates MOM substrates";Reactome:R-HSA-9861563 "CTLH E3 ligase ubiquitinates LDHA";Reactome:R-HSA-9861640 "CTLH E3 ligase ubiquitinates PKM-1";Reactome:R-HSA-9929350 "Ubiquitination of CD274 by BTRC-SCF E3-ligase complex";Reactome:R-HSA-9934753 "CBLL1 ubiquitinates CDH1";Reactome:R-HSA-9948301 "ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit";Reactome:R-HSA-9954721 "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide";Reactome:R-HSA-9955146 "S.flexneri ipaH9.8 ubiquitinates GBPs";Reactome:R-HSA-9970191 "RBBP6 activates CPSF complex" molecular_function GO:0004855 xanthine oxidase activity xrefs MetaCyc:XANTHINE-OXIDASE-RXN;Reactome:R-HSA-74258 "XDH oxidizes xanthine to form urate";Reactome:R-HSA-9748991 "XDH oxidises 6MP to 6TU";RHEA:21132 WAS EC:1.17.3.2;MetaCyc:XANTHINE-OXIDASE-RXN;Reactome:R-HSA-74258 "XDH oxidizes xanthine to form urate";Reactome:R-HSA-9748991 "XDH oxidises 6MP to 6TU";RHEA:21132 molecular_function GO:0004867 serine-type endopeptidase inhibitor activity xrefs Reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1";Reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1";Reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin";Reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-9823284 "FXa binds SERPINC1:HS" WAS Reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1";Reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1";Reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin";Reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR";Reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR" molecular_function GO:0005085 guanyl-nucleotide exchange factor activity xrefs Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS";Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS";Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA";Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP";Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)";Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)";Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4";Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers";Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers";Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers";Reactome:R-HSA-1433415 "Activation of RAC1";Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1";Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity";Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1";Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1";Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL";Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)";Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)";Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP";Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)";Reactome:R-HSA-187746 "RIT/RIN are activated";Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth";Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP";Reactome:R-HSA-2029451 "Activation of RAC1 by VAV";Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO";Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding";Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor";Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)";Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)";Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3";Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)";Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt";Reactome:R-HSA-2730840 "Activation of RAC1 by VAV";Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation";Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs";Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs";Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11";Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi";Reactome:R-HSA-381727 "RAP1A exchanges GDP for GTP";Reactome:R-HSA-389348 "Activation of Rac1 by pVav1";Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1";Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras";Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12";Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it";Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it";Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it";Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA";Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor";Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange";Reactome:R-HSA-399938 "Activation of Rac1 by FARP2";Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq";Reactome:R-HSA-400037 "Gi,Go Heterotrimeric G-protein complex dissociates";Reactome:R-HSA-400092 "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins";Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-416530 "FFAR1:FFAR1 ligands activate Gq";Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF";Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1";Reactome:R-HSA-418850 "Activation of Cdc42";Reactome:R-HSA-418856 "Activation of Rac1";Reactome:R-HSA-419166 "GEFs activate RhoA,B,C";Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t";Reactome:R-HSA-428535 "Activation of RAC1 by SOS";Reactome:R-HSA-428750 "Gq activation by TP receptor";Reactome:R-HSA-428917 "G13 activation by TP receptor";Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases";Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases";Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases";Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS";Reactome:R-HSA-445064 "Activation of Rac1 by VAV2";Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism";Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1";Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A";Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4";Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A";Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)";Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)";Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655277 "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange";Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS";Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS";Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1";Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange";Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF";Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane";Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange";Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz";Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13";Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange";Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex";Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18";Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1";Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET";Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET";Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A";Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5";Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1";Reactome:R-HSA-8875591 "DOCK7 activates RAC1";Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10";Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8";Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9";Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6";Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12";Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13";Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14";Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21";Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27";Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31";Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7";Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1";Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35";Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38";Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39";Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18";Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated";Reactome:R-HSA-8980691 "RHOA GEFs activate RHOA";Reactome:R-HSA-8982637 "Opsins binds G alpha-t";Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)";Reactome:R-HSA-9013023 "RHOB GEFs activate RHOB";Reactome:R-HSA-9013109 "RHOC GEFs activate RHOC";Reactome:R-HSA-9013143 "RAC1 GEFs activate RAC1";Reactome:R-HSA-9013159 "CDC42 GEFs activate CDC42";Reactome:R-HSA-9013435 "RHOD auto-activates";Reactome:R-HSA-9014296 "RAC2 GEFs activate RAC2";Reactome:R-HSA-9014433 "RHOG GEFs activate RHOG";Reactome:R-HSA-9017491 "RHOJ GEFs activate RHOJ";Reactome:R-HSA-9018747 "RHOQ GEFs activate RHOQ";Reactome:R-HSA-9018768 "RHOU auto-activates";Reactome:R-HSA-9018804 "RAC3 GEFs activate RAC3";Reactome:R-HSA-9018817 "RHOT1 GEFs activate RHOT1";Reactome:R-HSA-9018825 "RHOT2 GEFs activate RHOT2";Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1";Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS";Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2";Reactome:R-HSA-9032798 "DOCK3 activates RAC1";Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1";Reactome:R-HSA-9036301 "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s";Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs";Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3";Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1";Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN";Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1";Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP";Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP";Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs";Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants";Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR";Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1";Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2";Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants";Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR";Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP";Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP";Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS";Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors";Reactome:R-HSA-9680385 "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS";Reactome:R-HSA-9693111 "RHOF auto-activates";Reactome:R-HSA-9695853 "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS";Reactome:R-HSA-9703441 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants";Reactome:R-HSA-9751201 "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1";Reactome:R-HSA-9970163 "SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)" WAS Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS";Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS";Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA";Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP";Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)";Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)";Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4";Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers";Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers";Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers";Reactome:R-HSA-1433415 "Activation of RAC1";Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1";Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity";Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1";Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1";Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL";Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)";Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)";Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP";Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)";Reactome:R-HSA-187746 "RIT/RIN are activated";Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth";Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP";Reactome:R-HSA-2029451 "Activation of RAC1 by VAV";Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO";Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding";Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor";Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)";Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)";Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3";Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)";Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt";Reactome:R-HSA-2730840 "Activation of RAC1 by VAV";Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation";Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs";Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs";Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11";Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi";Reactome:R-HSA-381727 "RAP1A exchanges GDP for GTP";Reactome:R-HSA-389348 "Activation of Rac1 by pVav1";Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1";Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras";Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12";Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it";Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it";Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it";Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA";Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor";Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange";Reactome:R-HSA-399938 "Activation of Rac1 by FARP2";Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq";Reactome:R-HSA-400037 "Gi,Go Heterotrimeric G-protein complex dissociates";Reactome:R-HSA-400092 "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins";Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-416530 "FFAR1:FFAR1 ligands activate Gq";Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF";Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1";Reactome:R-HSA-418850 "Activation of Cdc42";Reactome:R-HSA-418856 "Activation of Rac1";Reactome:R-HSA-419166 "GEFs activate RhoA,B,C";Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t";Reactome:R-HSA-428535 "Activation of RAC1 by SOS";Reactome:R-HSA-428750 "Gq activation by TP receptor";Reactome:R-HSA-428917 "G13 activation by TP receptor";Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases";Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases";Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases";Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS";Reactome:R-HSA-445064 "Activation of Rac1 by VAV2";Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism";Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1";Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it";Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A";Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4";Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A";Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)";Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)";Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655277 "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange";Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange";Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS";Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS";Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1";Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange";Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF";Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane";Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange";Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz";Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13";Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange";Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex";Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18";Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1";Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET";Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET";Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A";Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5";Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1";Reactome:R-HSA-8875591 "DOCK7 activates RAC1";Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10";Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8";Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9";Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6";Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12";Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13";Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14";Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21";Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27";Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31";Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7";Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1";Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35";Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38";Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39";Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18";Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated";Reactome:R-HSA-8980691 "RHOA GEFs activate RHOA";Reactome:R-HSA-8982637 "Opsins binds G alpha-t";Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)";Reactome:R-HSA-9013023 "RHOB GEFs activate RHOB";Reactome:R-HSA-9013109 "RHOC GEFs activate RHOC";Reactome:R-HSA-9013143 "RAC1 GEFs activate RAC1";Reactome:R-HSA-9013159 "CDC42 GEFs activate CDC42";Reactome:R-HSA-9013435 "RHOD auto-activates";Reactome:R-HSA-9014296 "RAC2 GEFs activate RAC2";Reactome:R-HSA-9014433 "RHOG GEFs activate RHOG";Reactome:R-HSA-9017491 "RHOJ GEFs activate RHOJ";Reactome:R-HSA-9018747 "RHOQ GEFs activate RHOQ";Reactome:R-HSA-9018768 "RHOU auto-activates";Reactome:R-HSA-9018804 "RAC3 GEFs activate RAC3";Reactome:R-HSA-9018817 "RHOT1 GEFs activate RHOT1";Reactome:R-HSA-9018825 "RHOT2 GEFs activate RHOT2";Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1";Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS";Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2";Reactome:R-HSA-9032798 "DOCK3 activates RAC1";Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1";Reactome:R-HSA-9036301 "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s";Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs";Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3";Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1";Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN";Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1";Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP";Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP";Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs";Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants";Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR";Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1";Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2";Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants";Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR";Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP";Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP";Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS";Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers";Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors";Reactome:R-HSA-9680385 "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS";Reactome:R-HSA-9693111 "RHOF auto-activates";Reactome:R-HSA-9695853 "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS";Reactome:R-HSA-9703441 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants";Reactome:R-HSA-9751201 "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1" molecular_function GO:0005457 GDP-fucose transmembrane transporter activity xrefs Reactome:R-HSA-5653596 "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen";Reactome:R-HSA-742345 "SLC35C1 transports GDP-Fuc from cytosol to Golgi lumen" WAS Reactome:R-HSA-5653596 "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen";Reactome:R-HSA-742345 "SLC35C1 transport GDP-Fuc from cytosol to Golgi lumen" molecular_function GO:0005476 carnitine:O-acyl-L-carnitine antiporter activity xrefs Reactome:R-HSA-200424 "Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane";Reactome:R-HSA-9971094 "SLC25A20 exports excess acyl-CAR" WAS Reactome:R-HSA-200424 "Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane" molecular_function GO:0008080 N-acetyltransferase activity xrefs Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2";Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2";Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842";Reactome:R-HSA-9636560 "Eis acetylates DUSP16";Reactome:R-HSA-9913373 "AAC(6)-Ib acetylates ciprofloxacin";Reactome:R-HSA-9971629 "Unknown NAT N-acetylates kynurenine" WAS Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2";Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2";Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842";Reactome:R-HSA-9636560 "Eis acetylates DUSP16";Reactome:R-HSA-9913373 "AAC(6)-Ib acetylates ciprofloxacin" molecular_function GO:0008106 alcohol dehydrogenase (NADP+) activity xrefs EC:1.1.1.2;MetaCyc:ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN;Reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";Reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";Reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";Reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";Reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";Reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";Reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";Reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";Reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";Reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";Reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";Reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3";Reactome:R-HSA-9937340 "DHRSX reduces dolichal to dolichol";RHEA:15937;RHEA:20193;RHEA:38111;RHEA:54916;RHEA:54920;RHEA:58328;RHEA:58332;RHEA:58336;RHEA:58364;RHEA:58368;RHEA:58372;RHEA:58376;RHEA:58380;RHEA:58384;RHEA:58400;RHEA:58404;RHEA:58408;RHEA:58416;RHEA:58420;RHEA:58424;RHEA:58428;RHEA:58432;RHEA:58436;RHEA:58668;RHEA:59448;RHEA:59452;RHEA:59456;RHEA:59460;RHEA:59464;RHEA:59928;RHEA:63496;RHEA:64708;RHEA:64712;RHEA:66448;RHEA:76611;RHEA:80723;RHEA:84055;RHEA:84059;RHEA:84063 WAS EC:1.1.1.2;MetaCyc:ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN;Reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";Reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";Reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";Reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";Reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";Reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";Reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";Reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";Reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";Reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";Reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";Reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3";Reactome:R-HSA-9937340 "DHRSX reduces dolichal to dolichol";RHEA:15937 molecular_function GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity xrefs EC:2.4.1.69;MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN;Reactome:R-HSA-9036987 "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec";Reactome:R-HSA-9603982 "FUT2 transfers Fuc to LeA to form LeB";Reactome:R-HSA-9603983 "FUT2 transfers Fuc to LeX to form LeY";RHEA:32175;RHEA:48792;RHEA:50664 WAS EC:2.4.1.69;MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN;Reactome:R-HSA-9036987 "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec";Reactome:R-HSA-9603982 "FUT2 transfers Fuc to LeA to form LeB";Reactome:R-HSA-9603983 "FUT2 transfers Fuc to LeX to form LeY";RHEA:48792;RHEA:50664 molecular_function GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity xrefs EC:2.4.3.6;MetaCyc:2.4.99.6-RXN;RHEA:18913;RHEA:52316;RHEA:56264;RHEA:65432;RHEA:80751;RHEA:80755 WAS EC:2.4.3.6;MetaCyc:2.4.99.6-RXN;RHEA:52316;RHEA:56264;RHEA:65432;RHEA:80755 molecular_function GO:0008177 succinate dehydrogenase (quinone) activity xrefs EC:1.3.5.1;KEGG_REACTION:R02164;MetaCyc:RXN-14971;Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex";Reactome:R-HSA-70994 "SDH complex dehydrogenates succinate";RHEA:13713;RHEA:27834;RHEA:29215;RHEA:33863;RHEA:40523;RHEA:75711 WAS EC:1.3.5.1;KEGG_REACTION:R02164;MetaCyc:RXN-14971;Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex";Reactome:R-HSA-70994 "SDH complex dehydrogenates succinate";RHEA:13713;RHEA:27834;RHEA:40523;RHEA:75711 molecular_function GO:0008233 peptidase activity xrefs EC:3.4.-.-;Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6";Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl";Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl";Reactome:R-HSA-3065958 "An unknown protease degrades ACACA";Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs";Reactome:R-HSA-3139027 "Maturation of HIV Virion";Reactome:R-HSA-376149 "Proteolytic processing of SLIT";Reactome:R-HSA-4167501 "An unknown protease degrades ACACB";Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)";Reactome:R-HSA-5655483 "USP1 autocleavage";Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB";Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC";Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)";Reactome:R-HSA-9935547 "Lysosomal degradation of ubiquitinated CDH1" WAS EC:3.4.-.-;Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6";Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl";Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl";Reactome:R-HSA-3065958 "An unknown protease degrades ACACA";Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs";Reactome:R-HSA-3139027 "Maturation of HIV Virion";Reactome:R-HSA-376149 "Proteolytic processing of SLIT";Reactome:R-HSA-4167501 "An unknown protease degrades ACACB";Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)";Reactome:R-HSA-5655483 "USP1 autocleavage";Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB";Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC";Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)";Reactome:R-HSA-9935547 "Lysosomal degradation of ubiqutinated CDH1" molecular_function GO:0008252 nucleotidase activity xrefs N/A WAS RHEA:22140 molecular_function GO:0008253 5'-nucleotidase activity xrefs EC:3.1.3.5;MetaCyc:5-NUCLEOTID-RXN;Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP";Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]";Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)";Reactome:R-HSA-109387 "(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]";Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]";Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)";Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)";Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]";Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]";Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG";Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)";Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+";Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN";Reactome:R-HSA-9755078 "NT5C2 tetramer dephosphorylates RBV-MP";RHEA:12484;RHEA:22140;RHEA:27714;RHEA:27718;RHEA:29359;RHEA:29375;RHEA:30815 WAS EC:3.1.3.5;MetaCyc:5-NUCLEOTID-RXN;Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP";Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]";Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)";Reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)";Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]";Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)";Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)";Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]";Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]";Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG";Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)";Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+";Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN";Reactome:R-HSA-9755078 "NT5C2 tetramer dephosphorylates RBV-MP";RHEA:12484;RHEA:27714;RHEA:27718;RHEA:29359;RHEA:29375;RHEA:30815 molecular_function GO:0008483 transaminase activity xrefs EC:2.6.1.-;Reactome:R-HSA-1237102 "Transamination of MOB to methionine";Reactome:R-HSA-9972889 "AADAT transaminates 3HKYN to xanthurenate" WAS EC:2.6.1.-;Reactome:R-HSA-1237102 "Transamination of MOB to methionine" molecular_function GO:0008650 rRNA (uridine-2'-O-ribose)-methyltransferase activity xrefs Reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine";RHEA:42720;RHEA:42728;RHEA:43092;RHEA:47760;RHEA:47764;RHEA:54152 WAS Reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine";RHEA:42720;RHEA:43092;RHEA:47760;RHEA:47764;RHEA:54152 molecular_function GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity xrefs EC:1.3.1.34;MetaCyc:RXN-20994;MetaCyc:RXN-20995;RHEA:12136;RHEA:45232;RHEA:53296;RHEA:53708 WAS EC:1.3.1.34;MetaCyc:RXN-20994;MetaCyc:RXN-20995;RHEA:12136;RHEA:45232 molecular_function GO:0008718 D-amino-acid dehydrogenase activity xrefs EC:1.4.5.1;MetaCyc:RXN-11193;RHEA:18125;RHEA:30091;RHEA:37219;RHEA:37255;RHEA:43572;RHEA:45996;RHEA:55948 WAS EC:1.4.5.1;MetaCyc:RXN-11193;RHEA:18125;RHEA:37219;RHEA:37255;RHEA:43572;RHEA:45996;RHEA:55948 molecular_function GO:0008735 L-carnitine CoA-transferase activity xrefs EC:2.8.3.21;RHEA:28526 WAS EC:2.8.3.21;RHEA:28338;RHEA:28526 molecular_function GO:0008753 NADPH dehydrogenase (quinone) activity xrefs EC:1.6.5.10;KEGG_REACTION:R07359;MetaCyc:RXN0-271;MetaCyc:RXN0-7385;RHEA:46164;RHEA:61980;RHEA:63492;RHEA:83239;RHEA:83247 WAS EC:1.6.5.10;KEGG_REACTION:R07359;MetaCyc:RXN0-271;MetaCyc:RXN0-7385;RHEA:46164;RHEA:61980;RHEA:63492;RHEA:83239 molecular_function GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity xrefs EC:5.1.3.14;MetaCyc:UDPGLCNACEPIM-RXN;Reactome:R-HSA-4085021 "GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP";Reactome:R-HSA-4088338 "Defective GNE does not hydrolyse UDP-GlcNAc";RHEA:17213 WAS EC:5.1.3.14;MetaCyc:UDPGLCNACEPIM-RXN;Reactome:R-HSA-4085021 "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP";Reactome:R-HSA-4088338 "Defective GNE does not hydrolyse UDP-GlcNAc";RHEA:17213 molecular_function GO:0008874 gluconate 5-dehydrogenase [NAD(P)+] activity xrefs EC:1.1.1.69;MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN;RHEA:23936;RHEA:23940 WAS EC:1.1.1.69;MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN molecular_function GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity xrefs EC:6.2.1.20;KEGG_REACTION:R07325;MetaCyc:ACYLACPSYNTH-RXN;RHEA:10696;RHEA:45588;RHEA:59164;RHEA:63628;RHEA:64888 WAS EC:6.2.1.20;KEGG_REACTION:R07325;MetaCyc:ACYLACPSYNTH-RXN;RHEA:10696;RHEA:45588;RHEA:63628;RHEA:64888 molecular_function GO:0008924 L-malate dehydrogenase (quinone) activity xrefs EC:1.1.5.4;MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN;MetaCyc:RXNI-3;RHEA:29083;RHEA:29087;RHEA:30095;RHEA:46012 WAS EC:1.1.5.4;MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN;MetaCyc:RXNI-3;RHEA:29083;RHEA:30095;RHEA:46012 molecular_function GO:0008962 phosphatidylglycerophosphatase activity xrefs EC:3.1.3.27;MetaCyc:PGPPHOSPHA-RXN;Reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG";RHEA:16725;RHEA:33752;RHEA:42305 WAS EC:3.1.3.27;MetaCyc:PGPPHOSPHA-RXN;Reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG";RHEA:16725;RHEA:33752 molecular_function GO:0008970 glycerophospholipid phospholipase A1 activity xrefs EC:3.1.1.32;MetaCyc:PHOSPHOLIPASE-A1-RXN;Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C";Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]";Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)";Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]";Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C";Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]";Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]";Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC";Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS";RHEA:18689;RHEA:35263;RHEA:38783;RHEA:38787;RHEA:40487;RHEA:41167;RHEA:41171;RHEA:41207;RHEA:42212;RHEA:43968;RHEA:44408;RHEA:44648;RHEA:53496;RHEA:56448;RHEA:62032;RHEA:62044;RHEA:62464;RHEA:62480;RHEA:62484;RHEA:62488;RHEA:66708;RHEA:67424;RHEA:67428;RHEA:73967;RHEA:73971;RHEA:73975;RHEA:74103;RHEA:74159;RHEA:74163;RHEA:74247;RHEA:74251;RHEA:76971;RHEA:76975;RHEA:76979;RHEA:76983 WAS EC:3.1.1.32;MetaCyc:PHOSPHOLIPASE-A1-RXN;Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C";Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]";Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)";Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]";Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C";Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]";Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]";Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC";Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS";RHEA:18689;RHEA:35263;RHEA:42212;RHEA:44408;RHEA:44648;RHEA:62032;RHEA:67424;RHEA:67428 molecular_function GO:0010326 L-methionine:oxo-acid transaminase activity xrefs EC:2.6.1.88;MetaCyc:R15-RXN;RHEA:31763;RHEA:47084;RHEA:47800 WAS EC:2.6.1.88;MetaCyc:R15-RXN;RHEA:31763;RHEA:47800 molecular_function GO:0010945 coenzyme A diphosphatase activity xrefs EC:3.6.1.77;MetaCyc:RXN-10811;Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT";Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT";Reactome:R-HSA-9837354 "NUDT8 hydrolyzes CoA-SH to PPANT";RHEA:49976;RHEA:49980;RHEA:50016;RHEA:50020;RHEA:50024;RHEA:50028;RHEA:50032;RHEA:50036;RHEA:50040;RHEA:50044;RHEA:64988;RHEA:64992;RHEA:65564;RHEA:65568;RHEA:67464;RHEA:67468;RHEA:67472;RHEA:67524;RHEA:67528;RHEA:67532;RHEA:67536;RHEA:67540;RHEA:67544 WAS EC:3.6.1.77;MetaCyc:RXN-10811;Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT";Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT";Reactome:R-HSA-9837354 "NUDT8 hydrolyzes CoA-SH to PPANT";RHEA:50044;RHEA:64988 molecular_function GO:0015020 glucuronosyltransferase activity xrefs EC:2.4.1.17;MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN;Reactome:R-HSA-158546 "UGTs glucuronate APAP to APAP-GlcA";Reactome:R-HSA-159179 "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG";Reactome:R-HSA-159194 "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG";Reactome:R-HSA-174916 "Formation of N-glucuronides";Reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates";Reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP";Reactome:R-HSA-5604954 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL";Reactome:R-HSA-5604975 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL";Reactome:R-HSA-5617143 "B4GAT1:LARGE transfers initial GlcA to matriglycan chain";Reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN";Reactome:R-HSA-9036102 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG";Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG";Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG";Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG";Reactome:R-HSA-9638097 "LARGE1,2 elongates matriglycan chain with GlcA";Reactome:R-HSA-9749977 "UGT1A6 glucuronates ST";Reactome:R-HSA-9756134 "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL";Reactome:R-HSA-9756156 "UGT1A3 lactonizes ATV to ATVL";Reactome:R-HSA-9756183 "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL";Reactome:R-HSA-9758661 "UGT2B7,2B17,1A3 glucuronidates PRED metabolites";RHEA:21032;RHEA:30631;RHEA:31483;RHEA:52448;RHEA:52452;RHEA:52456;RHEA:52460;RHEA:52464;RHEA:52468;RHEA:52472;RHEA:52476;RHEA:52880;RHEA:52916;RHEA:52920;RHEA:52924;RHEA:52940;RHEA:52944;RHEA:52948;RHEA:52952;RHEA:52956;RHEA:52960;RHEA:52964;RHEA:52968;RHEA:53000;RHEA:53004;RHEA:53028;RHEA:53032;RHEA:53036;RHEA:53040;RHEA:53048;RHEA:53052;RHEA:53060;RHEA:53064;RHEA:53068;RHEA:53072;RHEA:53080;RHEA:53388;RHEA:55768;RHEA:55776;RHEA:55780;RHEA:55784;RHEA:55836;RHEA:55840;RHEA:55844;RHEA:56160;RHEA:56508;RHEA:63588;RHEA:63612;RHEA:63616;RHEA:63692;RHEA:63696;RHEA:63700;RHEA:63704;RHEA:63716;RHEA:63720;RHEA:63724;RHEA:63728;RHEA:63732;RHEA:63744;RHEA:63748;RHEA:74563;RHEA:75099;RHEA:79067;RHEA:79071;RHEA:79075 WAS EC:2.4.1.17;MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN;Reactome:R-HSA-158546 "UGTs glucuronate APAP to APAP-GlcA";Reactome:R-HSA-159179 "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG";Reactome:R-HSA-159194 "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG";Reactome:R-HSA-174916 "Formation of N-glucuronides";Reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates";Reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP";Reactome:R-HSA-5604954 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL";Reactome:R-HSA-5604975 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL";Reactome:R-HSA-5617143 "B4GAT1:LARGE transfers initial GlcA to matriglycan chain";Reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN";Reactome:R-HSA-9036102 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG";Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG";Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG";Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG";Reactome:R-HSA-9638097 "LARGE1,2 elongates matriglycan chain with GlcA";Reactome:R-HSA-9749977 "UGT1A6 glucuronates ST";Reactome:R-HSA-9756134 "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL";Reactome:R-HSA-9756156 "UGT1A3 lactonizes ATV to ATVL";Reactome:R-HSA-9756183 "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL";Reactome:R-HSA-9758661 "UGT2B7,2B17,1A3 glucuronidates PRED metabolites";RHEA:21032;RHEA:63616;RHEA:63692;RHEA:63716;RHEA:63720;RHEA:63728;RHEA:63744;RHEA:63748;RHEA:75099;RHEA:79067;RHEA:79071;RHEA:79075 molecular_function GO:0015035 protein-disulfide reductase activity xrefs Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds";Reactome:R-HSA-264997 "P4HB mediates disulfide bond formation in Proinsulin";Reactome:R-HSA-9817575 "ERO1B oxidizes P4HB" WAS Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds";Reactome:R-HSA-264997 "P4HB mediates disulfide bond formation in Proinsulin";Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1";Reactome:R-HSA-9817575 "ERO1B oxidizes P4HB" molecular_function GO:0015199 amino-acid betaine transmembrane transporter activity xrefs Reactome:R-HSA-6797957 "SLC22A4 transports BET from mitochondrial matrix to cytosol" WAS N/A molecular_function GO:0015220 choline transmembrane transporter activity xrefs Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol";Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol";Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol";Reactome:R-HSA-6797956 "SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix" WAS Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol";Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol";Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol";Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix" molecular_function GO:0015450 protein-transporting ATPase activity xrefs N/A WAS Reactome:R-HSA-1222523 "SodB gets secreted" molecular_function GO:0016279 protein-lysine N-methyltransferase activity xrefs Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27";Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex";Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB";Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A";Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8";Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2";Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN";Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP";Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1";Reactome:R-HSA-9844111 "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP";Reactome:R-HSA-9854315 "CSKMT methylates Citrate Synthase";RHEA:51000;RHEA:51736;RHEA:54192;RHEA:55544;RHEA:67108 WAS Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27";Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex";Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB";Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A";Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8";Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2";Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN";Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP";Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1";Reactome:R-HSA-9844111 "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP";Reactome:R-HSA-9854315 "CSKMT methylates Citrate Synthase";RHEA:51736;RHEA:54192 molecular_function GO:0016289 acyl-CoA hydrolase activity xrefs Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH";RHEA:19741;RHEA:28542;RHEA:31511;RHEA:38291;RHEA:40219;RHEA:40575;RHEA:40583;RHEA:40587;RHEA:40591;RHEA:40595;RHEA:45716;RHEA:46224;RHEA:49444;RHEA:59936;RHEA:66704;RHEA:70331;RHEA:70411;RHEA:70415;RHEA:70419;RHEA:70423;RHEA:70427;RHEA:78267 WAS Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH";RHEA:19741;RHEA:28542;RHEA:31511;RHEA:40219;RHEA:45716;RHEA:46224;RHEA:49444;RHEA:59936;RHEA:66704;RHEA:70331;RHEA:70411;RHEA:70415;RHEA:70419;RHEA:70423;RHEA:70427;RHEA:78267 molecular_function GO:0016406 carnitine O-acyltransferase activity xrefs Reactome:R-HSA-200410 "CPT2 converts acylcarnitine to acyl-CoA";Reactome:R-HSA-9971123 "CRAT transfers ISB to CAR" WAS Reactome:R-HSA-200410 "CPT2 converts acylcarnitine to acyl-CoA" molecular_function GO:0016428 tRNA (cytidine-N5)-methyltransferase activity xrefs EC:2.1.1.202;Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)";Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)";Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)";Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)";Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)";RHEA:21124;RHEA:42940;RHEA:42944;RHEA:42948;RHEA:42952;RHEA:42956;RHEA:51160;RHEA:51164;RHEA:51172;RHEA:51176;RHEA:51180;RHEA:53076;RHEA:54136;RHEA:54140;RHEA:61468;RHEA:61488;RHEA:61584;RHEA:61988 WAS EC:2.1.1.202;Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)";Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)";Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)";Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)";Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)";RHEA:42940;RHEA:42944;RHEA:42948;RHEA:42952;RHEA:42956;RHEA:51160;RHEA:51164;RHEA:51172;RHEA:51180;RHEA:53076;RHEA:54136;RHEA:54140;RHEA:61468;RHEA:61488;RHEA:61988 molecular_function GO:0016532 superoxide dismutase copper chaperone activity xrefs Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1" WAS N/A molecular_function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen xrefs EC:1.14.14.-;EC:1.14.14.1;MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN;Reactome:R-HSA-194678 "CYP51A1 demethylates LAN";Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine";RHEA:17149;RHEA:51984;RHEA:68160;RHEA:75847;RHEA:75863;RHEA:76419 WAS EC:1.14.14.-;EC:1.14.14.1;MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN;Reactome:R-HSA-194678 "CYP51A1 demethylates LAN";Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine";RHEA:17149 molecular_function GO:0016887 ATP hydrolysis activity xrefs Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)";Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70";Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse";Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90";Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA";Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE";Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi";Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER";Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation";Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN";Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN";Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane";Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating";Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex";Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG";Reactome:R-HSA-917693 "ESCRT Disassembly";Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP";Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope";Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP";Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex";Reactome:R-HSA-9943614 "CHD2-dependent H3.3 deposition at MYOG gene";Reactome:R-HSA-9944087 "CHD6-9-dependent ATP hydrolysis";Reactome:R-HSA-9944091 "NuRD hydrolyzes ATP to affect nucleosome organization";Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide";Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide";Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide";RHEA:13065 WAS Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)";Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70";Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse";Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90";Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA";Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE";Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi";Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER";Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation";Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN";Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN";Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane";Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating";Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex";Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG";Reactome:R-HSA-917693 "ESCRT Disassembly";Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP";Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope";Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP";Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex";Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide";Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide";Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide";RHEA:13065 molecular_function GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity xrefs EC:2.4.1.65;MetaCyc:2.4.1.65-RXN;Reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc";Reactome:R-HSA-9603986 "FUT3 transfers Fuc to Type 1 chains to form LeA";RHEA:23628;RHEA:48328;RHEA:48824;RHEA:62844;RHEA:62848 WAS EC:2.4.1.65;MetaCyc:2.4.1.65-RXN;Reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc";Reactome:R-HSA-9603986 "FUT3 transfers Fuc to Type 1 chains to form LeA";RHEA:23628;RHEA:48824;RHEA:62844;RHEA:62848 molecular_function GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity xrefs EC:1.3.1.2;MetaCyc:1.3.1.2-RXN;Reactome:R-HSA-73585 "reduction of uracil to form dihydrouracil";Reactome:R-HSA-73616 "reduction of thymine to form 5,6-Dihydrothymine";RHEA:18093 WAS EC:1.3.1.2;MetaCyc:1.3.1.2-RXN;Reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+";Reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+";RHEA:18093 molecular_function GO:0017128 phospholipid scramblase activity xrefs Reactome:R-HSA-9853809 "ANO6 exposes PS, PE on the platelet membrane";Reactome:R-HSA-9853849 "Defective ANO6 does not expose PS, PE on the platelet membrane";Reactome:R-HSA-9854657 "ANO5, ANO6 expose PS, PE on endothelial cells" WAS N/A molecular_function GO:0017150 tRNA dihydrouridine synthase activity xrefs MetaCyc:RXN0-1281;Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs";RHEA:23624;RHEA:53336;RHEA:53340;RHEA:53360;RHEA:53364;RHEA:54452 WAS MetaCyc:RXN0-1281;Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs";RHEA:23624;RHEA:54452 molecular_function GO:0018618 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity xrefs EC:1.14.12.1;MetaCyc:1.14.12.1-RXN;RHEA:11072;RHEA:11076;UM-BBD_reactionID:r0577 WAS EC:1.14.12.1;MetaCyc:1.14.12.1-RXN;UM-BBD_reactionID:r0577 molecular_function GO:0018812 3-hydroxyacyl-CoA dehydratase activity xrefs EC:4.2.1.150;EC:4.2.1.74;MetaCyc:ENOYL-COA-HYDRAT-RXN;Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA";Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA";Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA";RHEA:16105;RHEA:30547;RHEA:31075;RHEA:31163;RHEA:31171;RHEA:31191;RHEA:31199;RHEA:33767;RHEA:35347;RHEA:35355;RHEA:35359;RHEA:39123;RHEA:39139;RHEA:40187;RHEA:40207;RHEA:45992;RHEA:46348;RHEA:46352;RHEA:47424;RHEA:47436;RHEA:47452;RHEA:52664;RHEA:71647;RHEA:72579;RHEA:76647;RHEA:78559;RHEA:78575;RHEA:78591;RHEA:78603;RHEA:78911;RHEA:78915;RHEA:82923;RHEA:82959;RHEA:82995;RHEA:83027;RHEA:83063;RHEA:83067;RHEA:83147;RHEA:83211;RHEA:83323;RHEA:83359;RHEA:83375;RHEA:83391;RHEA:84395;RHEA:84399;RHEA:84403;RHEA:84407;RHEA:84627;RHEA:84631;RHEA:84659;RHEA:84663;RHEA:84667;RHEA:85127 WAS EC:4.2.1.150;EC:4.2.1.74;MetaCyc:ENOYL-COA-HYDRAT-RXN;Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA";Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA";Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA";Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA";Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA";RHEA:16105;RHEA:33767;RHEA:35347;RHEA:35355;RHEA:35359;RHEA:46348;RHEA:46352;RHEA:52664;RHEA:71647 molecular_function GO:0019206 nucleoside kinase activity xrefs Reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)";Reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]";Reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]";Reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP";Reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs";Reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)";Reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]";Reactome:R-HSA-73632 "phosphorylation of 2'-Deoxythymidine to dTMP" WAS Reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)";Reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]";Reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]";Reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP";Reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs";Reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)";Reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]";Reactome:R-HSA-73632 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]" molecular_function GO:0019789 SUMO transferase activity xrefs Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3";Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3";Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1";Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1";Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2";Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1";Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1";Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2";Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3";Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1";Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2";Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3";Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1";Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1";Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1";Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1";Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1";Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1";Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1";Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1";Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3";Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1";Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1";Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1";Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1";Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1";Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2";Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1";Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1";Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1";Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1";Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1";Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1";Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1";Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1";Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1";Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1";Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1";Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3";Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1";Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1";Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1";Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3";Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1";Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1";Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1";Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1";Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1";Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1";Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1";Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1";Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1";Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1";Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1";Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2";Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1";Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2";Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1";Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2";Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1";Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3";Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1";Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1";Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1";Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1";Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2";Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1";Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1";Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1";Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1";Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3";Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3";Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1";Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1";Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1";Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3";Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3";Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1";Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3";Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2";Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1";Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1";Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2";Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1";Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3";Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1";Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3";Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1";Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1";Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1";Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3";Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1";Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1";Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1";Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3";Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1";Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1";Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1";Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3";Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1";Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)";Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1";Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1";Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1";Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1";Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1";Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)";Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2";Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3";Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1";Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1";Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1";Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3";Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3";Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3";Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1";Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1";Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1";Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1";Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3";Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3";Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1";Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1";Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1";Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1";Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs";Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1";Reactome:R-HSA-6790454 "SUMOylation of XPC";Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2";Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2";Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1";Reactome:R-HSA-9920126 "UBC9 SUMOylates NS5";Reactome:R-HSA-9926476 "UBE2I sumoylates MITF-M";Reactome:R-HSA-9940458 "GATAD2B is SUMOylated";Reactome:R-HSA-9940470 "GATAD2A is SUMOylated" WAS Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)";Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3";Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3";Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1";Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1";Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2";Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1";Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1";Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2";Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3";Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1";Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2";Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3";Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1";Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1";Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1";Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1";Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1";Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1";Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1";Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1";Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3";Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1";Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1";Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1";Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1";Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1";Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2";Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1";Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1";Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1";Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1";Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1";Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1";Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1";Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1";Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1";Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1";Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1";Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3";Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1";Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1";Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1";Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3";Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1";Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1";Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1";Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1";Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1";Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1";Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1";Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1";Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1";Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1";Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1";Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2";Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1";Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2";Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1";Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2";Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1";Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3";Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1";Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1";Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1";Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1";Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2";Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1";Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1";Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1";Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1";Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3";Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3";Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1";Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1";Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1";Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3";Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3";Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1";Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3";Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2";Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1";Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1";Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2";Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1";Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3";Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1";Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3";Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1";Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1";Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1";Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3";Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1";Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1";Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1";Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3";Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1";Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1";Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1";Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3";Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1";Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)";Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1";Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1";Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1";Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1";Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1";Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)";Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2";Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3";Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1";Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1";Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1";Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3";Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3";Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3";Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1";Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1";Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1";Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1";Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3";Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3";Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1";Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1";Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1";Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1";Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs";Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1";Reactome:R-HSA-6790454 "SUMOylation of XPC";Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2";Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2";Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1";Reactome:R-HSA-9920126 "UBC9 SUMOylates NS5";Reactome:R-HSA-9926476 "UBE2I sumoylates MITF-M" molecular_function GO:0022842 narrow pore channel activity xrefs Reactome:R-HSA-1855161 "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol";Reactome:R-HSA-1855168 "I(1,3,4,5)P4 transports from the cytosol to the nucleus";Reactome:R-HSA-1855173 "5-PP-IP4 transports from the nucleus to the cytosol";Reactome:R-HSA-1855188 "IP6 transports from the cytosol to the nucleus";Reactome:R-HSA-1855190 "I(1,4,5)P3 transports from the cytosol to the nucleus";Reactome:R-HSA-1855201 "I(1,3,4,6)P4 transports from the cytosol to the nucleus";Reactome:R-HSA-1855203 "5-PP-IP5 transports from the nucleus to the cytosol";Reactome:R-HSA-1855212 "1/3-PP-IP5 transports from the cytosol to the nucleus";Reactome:R-HSA-1855220 "(PP)2-IP4 transports from the nucleus to the cytosol" WAS N/A molecular_function GO:0030343 vitamin D 25-hydroxylase activity xrefs EC:1.14.14.24;MetaCyc:RXN-9829;Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D";Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D";RHEA:32903 WAS MetaCyc:RXN-9829;Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D";Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D";RHEA:32903 molecular_function GO:0033721 aldehyde dehydrogenase (NADP+) activity xrefs EC:1.2.1.4;MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN;RHEA:11888;RHEA:27918;RHEA:28410;RHEA:30803;RHEA:34215;RHEA:47928;RHEA:59428;RHEA:59904;RHEA:59908;RHEA:59912;RHEA:59916;RHEA:60680;RHEA:60684;RHEA:60692;RHEA:60716;RHEA:60720;RHEA:60724;RHEA:60728;RHEA:60732;RHEA:60736;RHEA:60740;RHEA:62248;RHEA:68412;RHEA:72535;RHEA:72539;RHEA:76651;RHEA:76659;RHEA:76663;RHEA:76671;RHEA:76967;RHEA:80815;RHEA:80819;RHEA:80823;RHEA:81423 WAS EC:1.2.1.4;MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN;RHEA:11888;RHEA:28410;RHEA:30803;RHEA:34215;RHEA:47928;RHEA:60680;RHEA:60684;RHEA:60716;RHEA:60728;RHEA:60732;RHEA:60736;RHEA:60740;RHEA:62248;RHEA:68412;RHEA:72535;RHEA:72539;RHEA:76671;RHEA:80823;RHEA:81423 molecular_function GO:0033797 selenate reductase activity xrefs EC:1.97.1.9;KEGG_REACTION:R07229;MetaCyc:RXN0-2101;RHEA:14029;RHEA:34939;RHEA:51636;RHEA:80603;UM-BBD_reactionID:r0828 WAS EC:1.97.1.9;KEGG_REACTION:R07229;MetaCyc:RXN0-2101;RHEA:14029;RHEA:51636;RHEA:80603;UM-BBD_reactionID:r0828 molecular_function GO:0036397 formate dehydrogenase (quinone) activity xrefs EC:1.17.5.3;KEGG_REACTION:R09494;MetaCyc:FORMATEDEHYDROG-RXN;RHEA:29063;RHEA:29067;RHEA:29071;RHEA:48592 WAS EC:1.17.5.3;KEGG_REACTION:R09494;MetaCyc:FORMATEDEHYDROG-RXN;RHEA:29063;RHEA:29071;RHEA:48592 molecular_function GO:0036441 2-dehydropantolactone reductase activity xrefs EC:1.1.1.358;KEGG_REACTION:R03155;RHEA:18981 WAS KEGG_REACTION:R03155;RHEA:18981 molecular_function GO:0038024 cargo receptor activity xrefs Reactome:R-HSA-203716 "eNOS:Caveolin-1 complex binds to Nostrin";Reactome:R-HSA-2160915 "Receptor-mediated uptake of HA";Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome";Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl";Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome";Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl";Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome";Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D";Reactome:R-HSA-350186 "CUBN binds GC:25(OH)D";Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network";Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane";Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome";Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl" WAS Reactome:R-HSA-203716 "eNOS:Caveolin-1 complex binds to Nostrin";Reactome:R-HSA-2160915 "Receptor-mediated uptake of HA";Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl";Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome";Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl";Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome";Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D";Reactome:R-HSA-350186 "CUBN binds GC:25(OH)D";Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome";Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl" molecular_function GO:0042054 histone methyltransferase activity xrefs Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)";Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)";Reactome:R-HSA-9822583 "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)";RHEA:10024;RHEA:60312;RHEA:67112;RHEA:67808 WAS Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)";Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)";Reactome:R-HSA-9822583 "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)";RHEA:10024 molecular_function GO:0042626 ATPase-coupled transmembrane transporter activity xrefs EC:7.2.2.-;Reactome:R-HSA-1222523 "SodB gets secreted";Reactome:R-HSA-1454916 "The ABCC family mediates organic anion transport";Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region";Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate";Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate";Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA";Reactome:R-HSA-5690340 "Defective ABCC6 does not transport organic anion from cytosol to extracellular region";Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol";Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12";Reactome:R-HSA-9659680 "ABCB1 transports xenobiotics out of the cell";Reactome:R-HSA-9750546 "ABCC4 transports TPMP substrates from cytosol to extracellular region";Reactome:R-HSA-9750617 "ABCC5 transports TPMP substrates from cytosol to extracellular region";Reactome:R-HSA-9753278 "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3";Reactome:R-HSA-9753283 "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3";Reactome:R-HSA-9753284 "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region";Reactome:R-HSA-9759454 "ABCB1 transports PREDN,PREDL out of kidney cells";Reactome:R-HSA-9759461 "ABCB1 transports PREDN,PREDL out of hepatic cells";Reactome:R-HSA-9794120 "ABCG2 transports Cipro from intestinal cell to extracellular space";Reactome:R-HSA-9794572 "ABCG2 transports Cipro from hepatic cell to extracellular space" WAS EC:7.2.2.-;Reactome:R-HSA-1454916 "The ABCC family mediates organic anion transport";Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region";Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate";Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate";Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA";Reactome:R-HSA-5690340 "Defective ABCC6 does not transport organic anion from cytosol to extracellular region";Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol";Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12";Reactome:R-HSA-9659680 "ABCB1 transports xenobiotics out of the cell";Reactome:R-HSA-9750546 "ABCC4 transports TPMP substrates from cytosol to extracellular region";Reactome:R-HSA-9750617 "ABCC5 transports TPMP substrates from cytosol to extracellular region";Reactome:R-HSA-9753278 "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3";Reactome:R-HSA-9753283 "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3";Reactome:R-HSA-9753284 "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region";Reactome:R-HSA-9759454 "ABCB1 transports PREDN,PREDL out of kidney cells";Reactome:R-HSA-9759461 "ABCB1 transports PREDN,PREDL out of hepatic cells";Reactome:R-HSA-9794120 "ABCG2 transports Cipro from intestinal cell to extracellular space";Reactome:R-HSA-9794572 "ABCG2 transports Cipro from hepatic cell to extracellular space" molecular_function GO:0043712 (R)-2-hydroxy-4-methylpentanoate CoA-transferase activity xrefs EC:2.8.3.24;RHEA:49440 WAS N/A molecular_function GO:0043770 demethylmenaquinone methyltransferase activity xrefs EC:2.1.1.163;MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN;MetaCyc:RXN-11046;MetaCyc:RXN-9191;RHEA:26466;RHEA:30063;RHEA:33255;RHEA:42640;RHEA:44776;RHEA:44780;RHEA:44784;RHEA:44788;RHEA:44792;RHEA:44796 WAS EC:2.1.1.163;MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN;MetaCyc:RXN-11046;MetaCyc:RXN-9191;RHEA:26466;RHEA:42640 molecular_function GO:0044104 2,5-dioxovalerate dehydrogenase (NAD+) activity xrefs MetaCyc:RXN-8775;RHEA:47152 WAS N/A molecular_function GO:0044183 protein folding chaperone xrefs Reactome:R-HSA-9018785 "RHOBTB2 binds GTP";Reactome:R-HSA-9683772 "Trimmed spike protein binds to calnexin";Reactome:R-HSA-9694337 "Trimmed spike protein binds to calnexin";Reactome:R-HSA-9855212 "SDHA binds to SDHB";Reactome:R-HSA-9865893 "MT-CYB is translated";Reactome:R-HSA-9866253 "apo-UQCRFS1 binds LYRM7" WAS Reactome:R-HSA-9018785 "RHOBTB2 binds GTP";Reactome:R-HSA-9855212 "SDHA binds to SDHB";Reactome:R-HSA-9865893 "MT-CYB is translated";Reactome:R-HSA-9866253 "apo-UQCRFS1 binds LYRM7" molecular_function GO:0044688 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity xrefs EC:3.1.4.56;MetaCyc:RXN-12356;MetaCyc:RXN-12357 {xref="skos:narrowMatch"};RHEA:35799;RHEA:35803 WAS N/A molecular_function GO:0047081 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity xrefs EC:1.14.13.242;MetaCyc:1.14.12.4-RXN;RHEA:10860;RHEA:10864 WAS EC:1.14.13.242;MetaCyc:1.14.12.4-RXN;RHEA:10864 molecular_function GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity xrefs EC:2.3.1.23;MetaCyc:2.3.1.23-RXN;Reactome:R-HSA-1482794 "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)";RHEA:12937;RHEA:33359;RHEA:35983;RHEA:35987;RHEA:35991;RHEA:35995;RHEA:35999;RHEA:37383;RHEA:37387;RHEA:37391;RHEA:37395;RHEA:37475;RHEA:37479;RHEA:37483;RHEA:37487;RHEA:37511;RHEA:37515;RHEA:37519;RHEA:37527;RHEA:37559;RHEA:37563;RHEA:37655;RHEA:37703;RHEA:37707;RHEA:37803;RHEA:37843;RHEA:37855;RHEA:37859;RHEA:37863;RHEA:37867 WAS EC:2.3.1.23;MetaCyc:2.3.1.23-RXN;Reactome:R-HSA-1482794 "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)";RHEA:12937;RHEA:33359;RHEA:35987;RHEA:37475;RHEA:37515;RHEA:37559;RHEA:37563;RHEA:37703;RHEA:37707;RHEA:37803;RHEA:37855;RHEA:37859;RHEA:37863;RHEA:37867 molecular_function GO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity xrefs EC:2.3.1.63;MetaCyc:2.3.1.63-RXN;RHEA:23992;RHEA:37715;RHEA:37747;RHEA:37783;RHEA:37787;RHEA:37811;RHEA:37839 WAS EC:2.3.1.63;MetaCyc:2.3.1.63-RXN;RHEA:23992;RHEA:37715;RHEA:37783;RHEA:37811;RHEA:37839 molecular_function GO:0047290 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity xrefs EC:2.4.3.7;KEGG_REACTION:R04635;MetaCyc:2.4.99.7-RXN;Reactome:R-HSA-981809 "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen";RHEA:41968;RHEA:48316;RHEA:53896;RHEA:56088;RHEA:65280;RHEA:65284;RHEA:65288;RHEA:77679 WAS EC:2.4.3.7;KEGG_REACTION:R04635;MetaCyc:2.4.99.7-RXN;Reactome:R-HSA-981809 "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen";RHEA:48316;RHEA:53896;RHEA:56088;RHEA:65280;RHEA:65284;RHEA:65288 molecular_function GO:0047305 (R)-3-amino-2-methylpropionate:pyruvate transaminase activity xrefs EC:2.6.1.40;KEGG_REACTION:R02050;MetaCyc:2.6.1.40-RXN;Reactome:R-HSA-909780 "(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine";RHEA:18393 WAS EC:2.6.1.40;KEGG_REACTION:R02050;MetaCyc:2.6.1.40-RXN;Reactome:R-HSA-909780 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine";RHEA:18393 molecular_function GO:0047372 monoacylglycerol lipase activity xrefs EC:3.1.1.23;MetaCyc:RXN-19280;Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL";Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid";Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase";Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase";Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2";Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG";Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL";Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG";RHEA:15245;RHEA:32875;RHEA:34019;RHEA:38363;RHEA:38487;RHEA:38491;RHEA:39959;RHEA:40607;RHEA:44312;RHEA:44316;RHEA:44320;RHEA:44688;RHEA:44728;RHEA:47072;RHEA:58040;RHEA:58076;RHEA:58080;RHEA:58084;RHEA:58088;RHEA:58092;RHEA:58096;RHEA:58100;RHEA:78151 WAS EC:3.1.1.23;MetaCyc:RXN-19280;Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL";Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid";Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase";Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)";Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase";Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2";Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG";Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL";Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG";RHEA:15245;RHEA:34019;RHEA:44688 molecular_function GO:0047429 nucleoside triphosphate diphosphatase activity xrefs EC:3.6.1.9;MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN;Reactome:R-HSA-9755030 "ITPA dimer dephosphorylates RBV-TP to RBV-MP";RHEA:23996;RHEA:27762;RHEA:44644;RHEA:58732;RHEA:58736;RHEA:58740;RHEA:58744 WAS EC:3.6.1.9;MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN;Reactome:R-HSA-9755030 "ITPA dimer dephosphorylates RBV-TP to RBV-MP";RHEA:23996;RHEA:44644 molecular_function GO:0047620 acylglycerol kinase activity xrefs EC:2.7.1.94;MetaCyc:ACYLGLYCEROL-KINASE-RXN;Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG";RHEA:19293;RHEA:33747;RHEA:39847;RHEA:41079;RHEA:43308;RHEA:43316;RHEA:43328;RHEA:63328 WAS EC:2.7.1.94;MetaCyc:ACYLGLYCEROL-KINASE-RXN;Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG";RHEA:19293;RHEA:33747;RHEA:39847 molecular_function GO:0047645 alkan-1-ol dehydrogenase (acceptor) activity xrefs EC:1.1.99.20;MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN;RHEA:14685;RHEA:17085;RHEA:27538;RHEA:27542;RHEA:33567;RHEA:33571;RHEA:48076;RHEA:51148;RHEA:76451;RHEA:76455;RHEA:76459;RHEA:76463 WAS EC:1.1.99.20;MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN;RHEA:14685;RHEA:17085;RHEA:33567;RHEA:33571;RHEA:48076;RHEA:51148;RHEA:76451;RHEA:76455;RHEA:76459;RHEA:76463 molecular_function GO:0047804 cysteine-S-conjugate beta-lyase activity xrefs EC:4.4.1.13;MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN;MetaCyc:RXN-6763;RHEA:13965;RHEA:18121;RHEA:22424;RHEA:64740;RHEA:64744;RHEA:64748;RHEA:64752;RHEA:64756;RHEA:64760 WAS EC:4.4.1.13;MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN;MetaCyc:RXN-6763;RHEA:13965;RHEA:18121;RHEA:22424;RHEA:64740;RHEA:64744;RHEA:64748;RHEA:64752;RHEA:64756 molecular_function GO:0047876 endoglycosylceramidase activity xrefs EC:3.2.1.123;MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN;RHEA:22288;RHEA:65540;RHEA:65544;RHEA:65548;RHEA:65552;RHEA:65556;RHEA:77675 WAS EC:3.2.1.123;MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN;RHEA:22288;RHEA:65540;RHEA:65544;RHEA:65548;RHEA:65552;RHEA:65556 molecular_function GO:0047961 glycine N-acyltransferase activity xrefs EC:2.3.1.13;MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1";Reactome:R-HSA-9971621 "GLYAT transfers ISB to glycine";RHEA:19869;RHEA:49772;RHEA:49780;RHEA:49788;RHEA:49792;RHEA:51272;RHEA:51364;RHEA:51368;RHEA:51372;RHEA:58536;RHEA:64240;RHEA:64244;RHEA:64248;RHEA:64252;RHEA:64256;RHEA:64260 WAS EC:2.3.1.13;MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1";RHEA:19869;RHEA:49788;RHEA:64244 molecular_function GO:0047962 glycine N-benzoyltransferase activity xrefs EC:2.3.1.71;KEGG_REACTION:R02452;MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN;Reactome:R-HSA-159566 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A";Reactome:R-HSA-159574 "GLYAT-like proteins transfer glycine to ST-CoA to form SUA";Reactome:R-HSA-9750001 "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid";Reactome:R-HSA-9971063 "GLYAT-like proteins transfer glycine to phenylacetyl-CoA";Reactome:R-HSA-9972916 "GLYAT-like proteins transfer glycine to aminobenzoyl-CoA";RHEA:18493 WAS EC:2.3.1.71;KEGG_REACTION:R02452;MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN;Reactome:R-HSA-159566 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A";Reactome:R-HSA-159574 "GLYAT-like proteins transfer glycine to ST-CoA to form SUA";Reactome:R-HSA-9750001 "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid";RHEA:18493 molecular_function GO:0050018 amino-acid dehydrogenase [NAD(P)+] activity xrefs EC:1.4.1.5;MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN;RHEA:10396;RHEA:32959;RHEA:37035;RHEA:37259;RHEA:47632;RHEA:65196 WAS EC:1.4.1.5;MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN;RHEA:10396 molecular_function GO:0050136 NADH dehydrogenase (quinone) (non-electrogenic) activity xrefs EC:1.6.5.9;MetaCyc:1.6.99.5-RXN;RHEA:46160;RHEA:60660;RHEA:61984;RHEA:69695;RHEA:74075;RHEA:74079;RHEA:83235;RHEA:83243 WAS EC:1.6.5.9;MetaCyc:1.6.99.5-RXN;RHEA:46160;RHEA:60660;RHEA:61984;RHEA:69695;RHEA:74075;RHEA:74079;RHEA:83235 molecular_function GO:0050153 omega-hydroxydecanoate dehydrogenase activity xrefs EC:1.1.1.66;KEGG_REACTION:R03886;MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN;Reactome:R-HSA-9971258 "ADH7 dehydrogenates 10-OH-DECA";RHEA:20880 WAS EC:1.1.1.66;KEGG_REACTION:R03886;MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN;RHEA:20880 molecular_function GO:0050207 plasmanylethanolamine desaturase activity xrefs EC:1.14.19.77;MetaCyc:RXN-17732;RHEA:22956;RHEA:61956;RHEA:61960;RHEA:61964;RHEA:61968;RHEA:61972 WAS EC:1.14.19.77;MetaCyc:RXN-17732;RHEA:22956;RHEA:61960;RHEA:61964;RHEA:61968;RHEA:61972 molecular_function GO:0050253 retinyl-palmitate esterase activity xrefs MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN;Reactome:R-HSA-2404133 "A REH hydrolyses atREs to atROL and FAs";Reactome:R-HSA-8848355 "PNPLA4 hydrolyzes retinyl palmitate";Reactome:R-HSA-975593 "PNLIP:CLPS hydrolyses RPALM to atROL and PALM";Reactome:R-HSA-975594 "PLB1 hydrolyses RPALM to atROL";RHEA:21508 WAS MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN;Reactome:R-HSA-2404133 "A REH hydrolses atREs to atROL and FAs";Reactome:R-HSA-8848355 "PNPLA4 hydrolyzes retinyl palmitate";Reactome:R-HSA-975593 "PNLIP:CLPS hydrolyses RPALM to atROL and PALM";Reactome:R-HSA-975594 "PLB1 hydrolyses RPALM to atROL";RHEA:21508 molecular_function GO:0050291 sphingosine N-acyltransferase activity xrefs EC:2.3.1.24;MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-428185 "Ceramide synthases transfer acyl-CoA onto sphingoid";RHEA:23768;RHEA:36687;RHEA:36691;RHEA:37111;RHEA:37115;RHEA:37123;RHEA:45284;RHEA:64044 WAS EC:2.3.1.24;MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN;Reactome:R-HSA-428185 "Ceramide synthases transfer acyl-CoA onto sphingoid";RHEA:23768;RHEA:36687;RHEA:36691;RHEA:37115;RHEA:37123;RHEA:45284;RHEA:64044 molecular_function GO:0052598 histamine oxidase activity xrefs KEGG_REACTION:R02150;MetaCyc:RXN-9600;Reactome:R-HSA-5696131 "AOC1 deaminates Hist";Reactome:R-HSA-9970023 "AOC1 dimer oxidizes MeHist";RHEA:25625 WAS KEGG_REACTION:R02150;MetaCyc:RXN-9600;Reactome:R-HSA-5696131 "AOC1 deaminates Hist";RHEA:25625 molecular_function GO:0052664 nitroalkane oxidase activity xrefs EC:1.7.3.1;KEGG_REACTION:R00799;KEGG_REACTION:R10389;MetaCyc:NITROETHANE-OXIDASE-RXN;MetaCyc:RXN-11045;RHEA:20976;RHEA:26490;RHEA:50772 WAS EC:1.7.3.1;KEGG_REACTION:R00799;KEGG_REACTION:R10389;MetaCyc:NITROETHANE-OXIDASE-RXN;MetaCyc:RXN-11045;RHEA:20976;RHEA:26490 molecular_function GO:0052797 4-O-methyl-glucuronoyl methylesterase activity xrefs EC:3.1.1.117;RHEA:67452 WAS N/A molecular_function GO:0052891 aliphatic (S)-hydroxynitrile lyase activity xrefs MetaCyc:RXN-11731;RHEA:56588;RHEA:56592;RHEA:77395;RHEA:77399;RHEA:77403;RHEA:77407;RHEA:77411;RHEA:77415;RHEA:77419;RHEA:77423;RHEA:77471;RHEA:77479;RHEA:77483;RHEA:77487;RHEA:77491;RHEA:77523;RHEA:77527;RHEA:77531 WAS MetaCyc:RXN-11731;RHEA:56588;RHEA:56592 molecular_function GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity xrefs EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9";RHEA:11508;RHEA:54276;RHEA:54280 WAS EC:1.14.11.16;MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN;Reactome:R-HSA-9631355 "ASPH:Fe2+ hydroxylates an aspartate residue of F9";RHEA:11508;RHEA:54276 molecular_function GO:0062105 RNA 2'-O-methyltransferase activity xrefs RHEA:24140;RHEA:42724;RHEA:42788;RHEA:42924;RHEA:43200;RHEA:43204;RHEA:47756;RHEA:47768;RHEA:47772;RHEA:47776;RHEA:48628;RHEA:56884;RHEA:58956;RHEA:65380;RHEA:73759 WAS RHEA:42724;RHEA:48628;RHEA:56884;RHEA:58956;RHEA:65380 molecular_function GO:0062154 N6-methyl-AMP deaminase activity xrefs Reactome:R-HSA-2161187 "MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine";Reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine";Reactome:R-HSA-9731661 "MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamine";RHEA:16001 WAS Reactome:R-HSA-2161187 "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine";Reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine";Reactome:R-HSA-9731661 "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine";RHEA:16001 molecular_function GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity xrefs EC:3.1.4.54;MetaCyc:RXN-12116;Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E";RHEA:33159;RHEA:45528;RHEA:45532;RHEA:45536;RHEA:45540;RHEA:45552;RHEA:45556;RHEA:45596;RHEA:45608;RHEA:45612;RHEA:45616;RHEA:45620;RHEA:56544;RHEA:56548 WAS EC:3.1.4.54;MetaCyc:RXN-12116;Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E";RHEA:33159;RHEA:45532;RHEA:45536;RHEA:45552;RHEA:45556;RHEA:45608;RHEA:45612;RHEA:45616;RHEA:45620;RHEA:56544;RHEA:56548 molecular_function GO:0070675 hypoxanthine oxidase activity xrefs Reactome:R-HSA-74247 "XDH oxidizes hypoxanthine to form xanthine";RHEA:68012 WAS Reactome:R-HSA-74247 "XDH oxidizes hypoxanthine to form xanthine" molecular_function GO:0070818 protoporphyrinogen oxidase activity xrefs RHEA:62000 WAS N/A molecular_function GO:0070819 protoporphyrinogen oxidase activity, quinone as acceptor xrefs EC:1.3.5.3;RHEA:27409;RHEA:63936;RHEA:65032 WAS N/A molecular_function GO:0080023 (2E)-enoyl-CoA hydratase activity xrefs EC:4.2.1.119;MetaCyc:RXN-7699;RHEA:26526;RHEA:39155;RHEA:39159;RHEA:39175;RHEA:39187;RHEA:39247;RHEA:39259;RHEA:39303;RHEA:39315;RHEA:39327;RHEA:39343;RHEA:39351;RHEA:39363;RHEA:39375;RHEA:39387;RHEA:39399;RHEA:39411;RHEA:39423;RHEA:39439;RHEA:39451;RHEA:39463;RHEA:39475;RHEA:39487;RHEA:39499;RHEA:39511;RHEA:39523;RHEA:39535;RHEA:39547;RHEA:39559;RHEA:39579;RHEA:39591;RHEA:39603;RHEA:39615;RHEA:39627;RHEA:39639;RHEA:39687;RHEA:39699;RHEA:44024;RHEA:46720;RHEA:67216;RHEA:67228;RHEA:72575;RHEA:78643;RHEA:78863;RHEA:78867;RHEA:78931 WAS EC:4.2.1.119;MetaCyc:RXN-7699;RHEA:26526;RHEA:39303;RHEA:39343;RHEA:39351;RHEA:39363;RHEA:39375;RHEA:39387;RHEA:39399;RHEA:39411;RHEA:39423;RHEA:39439;RHEA:39475;RHEA:39487;RHEA:39499;RHEA:39511;RHEA:39523;RHEA:39535;RHEA:39547;RHEA:39559;RHEA:39579;RHEA:39591;RHEA:39603;RHEA:39615;RHEA:39627;RHEA:39639;RHEA:39687;RHEA:39699;RHEA:46720;RHEA:67216;RHEA:67228;RHEA:72575;RHEA:78863;RHEA:78867;RHEA:78931 molecular_function GO:0097265 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity xrefs Reactome:R-HSA-2161776 "5S-HETE is oxidised to 5-oxoETE by 5-HEDH";RHEA:48656 WAS Reactome:R-HSA-2161776 "5S-HETE is oxidised to 5-oxoETE by 5-HEDH" molecular_function GO:0097621 monoamine oxidase activity xrefs EC:1.4.3.4;RHEA:26414;RHEA:51168 WAS EC:1.4.3.4;RHEA:26414 molecular_function GO:0102157 sulfopropanediol 3-dehydrogenase activity xrefs EC:1.1.1.308;MetaCyc:RXN-11727;RHEA:28074 {status="skos:exactMatch"} WAS MetaCyc:RXN-11729 molecular_function GO:0102175 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity xrefs EC:1.1.1.418;MetaCyc:RXN-11928;RHEA:20669;RHEA:34775;RHEA:59016;RHEA:60084;RHEA:60092 WAS EC:1.1.1.418;MetaCyc:RXN-11928;RHEA:20669;RHEA:34775;RHEA:59016;RHEA:60084 molecular_function GO:0102177 4alpha-monomethylsterol monooxygenase activity xrefs EC:1.14.18.11;MetaCyc:RXN-19724;RHEA:58868 WAS EC:1.14.18.11;MetaCyc:RXN-11930;RHEA:58872 molecular_function GO:0102232 acrolein reductase activity xrefs MetaCyc:RXN-12281;RHEA:64716 WAS MetaCyc:RXN-12281 molecular_function GO:0102394 L-isoleucine 4-hydroxylase activity xrefs EC:1.14.11.45;MetaCyc:RXN-13637;RHEA:41448 WAS MetaCyc:RXN-13637 molecular_function GO:0102443 L-2-hydroxycarboxylate dehydrogenase (NAD+) activity xrefs EC:1.1.1.337;MetaCyc:RXN-13927;Reactome:R-HSA-9971565 "Unknown enzyme hydrogenates HPP";RHEA:10176;RHEA:15533;RHEA:34555;RHEA:36371 WAS EC:1.1.1.337;MetaCyc:RXN-13927;RHEA:10176;RHEA:15533;RHEA:34555;RHEA:36371 molecular_function GO:0102673 fatty aldehyde dehydrogenase (NAD+) activity xrefs MetaCyc:RXN-4142;RHEA:44008;RHEA:44016;RHEA:49832;RHEA:69092;RHEA:69771 WAS MetaCyc:RXN-4142;RHEA:44008;RHEA:49832;RHEA:69771 molecular_function GO:0102772 sphingolipid C4-monooxygenase activity xrefs EC:1.14.18.5;MetaCyc:RXN-14250;Reactome:R-HSA-428260 "DEGS2 oxygenates dihydroceramide";RHEA:33599;RHEA:33679;RHEA:43116;RHEA:46364;RHEA:55476;RHEA:55808;RHEA:81475 WAS EC:1.14.18.5;MetaCyc:RXN-14250;Reactome:R-HSA-428260 "DEGS2 oxygenates dihydroceramide";RHEA:46364;RHEA:55476;RHEA:55808;RHEA:81475 molecular_function GO:0102993 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity xrefs EC:1.14.19.35;MetaCyc:RXN-1727;MetaCyc:RXN-8295;MetaCyc:RXN-8297;MetaCyc:RXN-8299;MetaCyc:RXN-8301;MetaCyc:RXN-8303;MetaCyc:RXN-8309;MetaCyc:RXN-8310;MetaCyc:RXN-8314;MetaCyc:RXN-8365;MetaCyc:RXN-8366;MetaCyc:RXN-9667;RHEA:46408;RHEA:46412;RHEA:66512;RHEA:66516;RHEA:66520 WAS EC:1.14.19.35;MetaCyc:RXN-1727;MetaCyc:RXN-8295;MetaCyc:RXN-8297;MetaCyc:RXN-8299;MetaCyc:RXN-8301;MetaCyc:RXN-8303;MetaCyc:RXN-8309;MetaCyc:RXN-8310;MetaCyc:RXN-8314;MetaCyc:RXN-8365;MetaCyc:RXN-8366;MetaCyc:RXN-9667;RHEA:46408;RHEA:46412 molecular_function GO:0106235 ceramide-1-phosphate phosphatase activity xrefs RHEA:33743;RHEA:50888;RHEA:62040 WAS RHEA:33743;RHEA:50888 molecular_function GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity xrefs EC:2.3.1.n7;RHEA:32995;RHEA:36015;RHEA:36019;RHEA:36023;RHEA:37419;RHEA:37495;RHEA:37499;RHEA:37503;RHEA:37523;RHEA:37575;RHEA:37579;RHEA:37727;RHEA:37731;RHEA:37767;RHEA:37771;RHEA:37775;RHEA:64204;RHEA:64228 WAS EC:2.3.1.n7;RHEA:32995;RHEA:36015;RHEA:36019;RHEA:36023;RHEA:37495;RHEA:37499;RHEA:37503;RHEA:37523;RHEA:37575;RHEA:37579;RHEA:37727;RHEA:37731;RHEA:37767;RHEA:37771;RHEA:37775 molecular_function GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity xrefs EC:2.3.1.n6;RHEA:33191;RHEA:37375;RHEA:37379;RHEA:37399;RHEA:37403;RHEA:37407;RHEA:37415;RHEA:37531;RHEA:37535;RHEA:37539;RHEA:37567;RHEA:37571;RHEA:37735;RHEA:37739 WAS EC:2.3.1.n6;RHEA:33191;RHEA:37399;RHEA:37403;RHEA:37415;RHEA:37531;RHEA:37539;RHEA:37567;RHEA:37571;RHEA:37735;RHEA:37739 molecular_function GO:0106339 tRNA (cytidine(32)-2'-O-ribose)-methyltransferase activity xrefs MetaCyc:RXN-11866;Reactome:R-HSA-9024159 "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)";RHEA:42932 WAS MetaCyc:RXN-11866;RHEA:42932 molecular_function GO:0106341 omega-hydroxyceramide transacylase activity xrefs EC:2.3.1.296;MetaCyc:RXN-20362;RHEA:55264;RHEA:61528;RHEA:65648;RHEA:65652;RHEA:65668;RHEA:65672;RHEA:65676;RHEA:65680;RHEA:65684;RHEA:65688;RHEA:65692;RHEA:65696;RHEA:78007;RHEA:78011;RHEA:78115;RHEA:78119 WAS EC:2.3.1.296;MetaCyc:RXN-20362;RHEA:61528;RHEA:65692;RHEA:78115;RHEA:78119 molecular_function GO:0106359 2-hydroxyacyl-CoA lyase activity xrefs EC:4.1.2.63;RHEA:25375;RHEA:25379;RHEA:67444;RHEA:67448 WAS EC:4.1.2.63;RHEA:25375;RHEA:25379;RHEA:67444 molecular_function GO:0106386 (3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity xrefs EC:1.1.1.n12;MetaCyc:RXN66-485;RHEA:32711;RHEA:40191;RHEA:40243;RHEA:45832;RHEA:67220;RHEA:67232;RHEA:78563;RHEA:78579;RHEA:78595;RHEA:78607;RHEA:78635;RHEA:78667;RHEA:78671;RHEA:78871;RHEA:78875;RHEA:78879;RHEA:78935;RHEA:79191 WAS EC:1.1.1.n12;MetaCyc:RXN66-485;RHEA:32711;RHEA:67220;RHEA:67232;RHEA:78871;RHEA:78875;RHEA:78879;RHEA:78935 molecular_function GO:0106388 rRNA small subunit aminocarboxypropyltransferase activity xrefs EC:2.5.1.157;RHEA:31479;RHEA:63292;RHEA:63296;RHEA:63300 WAS EC:2.5.1.157;RHEA:63292;RHEA:63296;RHEA:63300 molecular_function GO:0106430 dihydroorotate dehydrogenase (quinone) activity xrefs EC:1.3.5.2;RHEA:28687;RHEA:28691;RHEA:29195;RHEA:29199;RHEA:30187 WAS EC:1.3.5.2;RHEA:28691;RHEA:29195;RHEA:30187 molecular_function GO:0106435 carboxylesterase activity xrefs EC:3.1.1.1;MetaCyc:CARBOXYLESTERASE-RXN;Reactome:R-HSA-9619024 "CES1 trimer hydrolyses ACEI pro-drugs to ACEIs";Reactome:R-HSA-9727567 "CES1 hydrolyses sacubitril to sacubitrilat";Reactome:R-HSA-9749647 "CES2 hydrolyzes ASA-";RHEA:21164;RHEA:31779;RHEA:38555;RHEA:47348;RHEA:47352;RHEA:47356;RHEA:47360;RHEA:47364;RHEA:47388;RHEA:47392;RHEA:50136;RHEA:50144;RHEA:50148;RHEA:59388;RHEA:63052 WAS EC:3.1.1.1;MetaCyc:CARBOXYLESTERASE-RXN;Reactome:R-HSA-9619024 "CES1 trimer hydrolyses ACEI pro-drugs to ACEIs";Reactome:R-HSA-9727567 "CES1 hydrolyses sacubitril to sacubitrilat";Reactome:R-HSA-9749647 "CES2 hydrolyzes ASA-";RHEA:21164;RHEA:31779;RHEA:38555;RHEA:50148;RHEA:59388;RHEA:63052 molecular_function GO:0106437 protein-glutamic acid ligase activity, initiating xrefs RHEA:60144;RHEA:69192;RHEA:69196 WAS RHEA:60144;RHEA:69192 molecular_function GO:0106438 protein-glutamic acid ligase activity, elongating xrefs RHEA:60148;RHEA:69208;RHEA:69212 WAS RHEA:60148;RHEA:69208 molecular_function GO:0120014 phospholipid transfer activity xrefs Reactome:R-HSA-216757 "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane";Reactome:R-HSA-382553 "ABCA7:Apo1A-mediated phospholipid efflux";Reactome:R-HSA-5678706 "ABCB4 transports PC from plasma membrane to extracellular region";Reactome:R-HSA-5678749 "Defective ABCB4 does not transport PC from plasma membrane to extracellular region";Reactome:R-HSA-8857662 "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane";Reactome:R-HSA-8865637 "MFSD2A transports LPC from extracellular region to plasma membrane";Reactome:R-HSA-8867876 "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" WAS N/A molecular_function GO:0120502 fatty acid omega-1 hydroxylase activity xrefs RHEA:39751;RHEA:39759;RHEA:41724;RHEA:44548 WAS RHEA:39751;RHEA:39759;RHEA:44548 molecular_function GO:0120515 fatty acid-CoA ligase activity xrefs MetaCyc:BUTYRATE--COA-LIGASE-RXN;RHEA:38883;RHEA:44004;RHEA:44196 WAS MetaCyc:BUTYRATE--COA-LIGASE-RXN;RHEA:38883;RHEA:44004 molecular_function GO:0120516 diacylglycerol lipase activity xrefs MetaCyc:RXN-19279;RHEA:18761;RHEA:32731;RHEA:33275;RHEA:35663;RHEA:38383;RHEA:38455;RHEA:38483;RHEA:38507;RHEA:38511;RHEA:38515;RHEA:38519;RHEA:38523;RHEA:38595;RHEA:38651;RHEA:38659;RHEA:39935;RHEA:39939;RHEA:40967;RHEA:41219;RHEA:42604;RHEA:44176;RHEA:44444;RHEA:44712;RHEA:44876;RHEA:47868;RHEA:48596;RHEA:78019;RHEA:78147 WAS MetaCyc:RXN-19279;RHEA:32731;RHEA:44444;RHEA:47868;RHEA:78019 molecular_function GO:0120521 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity xrefs EC:1.14.18.6;MetaCyc:RXN3O-4042;RHEA:46520;RHEA:64532 WAS MetaCyc:RXN3O-4042;RHEA:46520;RHEA:64532 molecular_function GO:0120528 2-(omega-methylthio)alkylmalate dehydratase activity xrefs EC:4.2.1.170;RHEA:50632;RHEA:50636;RHEA:50648;RHEA:50652;RHEA:50656;RHEA:50660 WAS EC:4.2.1.170;RHEA:50632;RHEA:50636 molecular_function GO:0120550 methyltransferase cap2 activity xrefs EC:2.1.1.296;MetaCyc:RXN-14928;RHEA:53044;RHEA:67024 WAS EC:2.1.1.296;MetaCyc:RXN-14928;RHEA:67024 molecular_function GO:0140085 L-amino-acid N-acetyltransferase activity xrefs RHEA:47656;RHEA:47660;RHEA:52680;RHEA:83863 WAS RHEA:83863 molecular_function GO:0140169 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity xrefs EC:1.1.1.213;EC:1.1.1.357;EC:1.1.1.50;RHEA:34779;RHEA:34783;RHEA:42116;RHEA:69016;RHEA:69028;RHEA:84155;RHEA:84199;RHEA:85551;RHEA:85559 WAS EC:1.1.1.213;EC:1.1.1.357;EC:1.1.1.50;RHEA:34779;RHEA:34783 molecular_function GO:0140293 ADP-ribosylglutamate-[protein] hydrolase activity xrefs RHEA:58248 WAS N/A molecular_function GO:0140318 protein transporter activity xrefs N/A WAS Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome";Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network";Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" molecular_function GO:0140324 lysophospholipase C activity xrefs RHEA:86371;RHEA:86375;RHEA:86379;RHEA:86383 WAS RHEA:86375;RHEA:86379 molecular_function GO:0140386 tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity xrefs EC:2.1.1.225;Reactome:R-HSA-6788668 "TRMT13 2'-O-methylates adenosine-4 in tRNA";Reactome:R-HSA-6788684 "TRMT13 2'-O-methylates cytidine-4 in tRNA";RHEA:32767;RHEA:43192;RHEA:43196 WAS EC:2.1.1.225;RHEA:32767;RHEA:43192;RHEA:43196 molecular_function GO:0140818 mRNA 5'-triphosphate monophosphatase activity xrefs EC:3.6.1.74;MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN;RHEA:11008;RHEA:60828;RHEA:60832;RHEA:67004 WAS EC:3.6.1.74;MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN;RHEA:11008;RHEA:67004 molecular_function GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity xrefs EC:3.6.1.59;RHEA:37099;RHEA:37103;RHEA:65384;RHEA:65388 WAS EC:3.6.1.59;RHEA:65384;RHEA:65388 molecular_function GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity xrefs EC:3.6.1.62;RHEA:37371;RHEA:60868;RHEA:60872;RHEA:67484 WAS EC:3.6.1.62;RHEA:37371;RHEA:67484 molecular_function GO:0160182 nitrate reductase (quinone) activity xrefs EC:1.7.5.1;RHEA:29119;RHEA:29123;RHEA:29127;RHEA:29131;RHEA:56144 WAS EC:1.7.5.1;RHEA:29119;RHEA:29127;RHEA:56144 molecular_function GO:0160191 steroid 22S-hydroxylase activity xrefs EC:1.14.14.178;MetaCyc:RXN-22825;MetaCyc:RXN-22826;MetaCyc:RXN-22827;RHEA:69831;RHEA:69835;RHEA:69839;RHEA:69871;RHEA:70003;RHEA:70059;RHEA:70063;RHEA:70067;RHEA:70071 WAS EC:1.14.14.178;MetaCyc:RXN-22825;MetaCyc:RXN-22826;MetaCyc:RXN-22827;RHEA:70059;RHEA:70063;RHEA:70067 molecular_function GO:0160302 6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity xrefs EC:2.1.1.400;KEGG_REACTION:R13499;RHEA:85483 WAS KEGG_REACTION:R13499;RHEA:85483 586 RELATION CHANGES biological_process GO:0000162 L-tryptophan biosynthetic process is_a GO:0009073;GO:0046219;GO:1902223 WAS GO:0006568;GO:0009073;GO:0046219;GO:1902223 biological_process GO:0001407 glycerophosphodiester transmembrane transport is_a GO:0015748;GO:0055085 WAS GO:0015711;GO:0015748;GO:0055085 biological_process GO:0001820 serotonin secretion is_a GO:0015850;GO:0023061;GO:0071705 WAS GO:0006837;GO:0023061 biological_process GO:0001927 exocyst assembly is_a GO:0065003 WAS GO:0065003;GO:0140029 relationship N/A WAS part_of GO:0006904 biological_process GO:0001928 regulation of exocyst assembly is_a GO:0043254 WAS GO:0043254;GO:0106020 biological_process GO:0006002 fructose 6-phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0006003 fructose 2,6-bisphosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0006173 dADP biosynthetic process is_a GO:0009153;GO:0009183;GO:0009189;GO:0046056 WAS GO:0009153;GO:0009183;GO:0046056 biological_process GO:0006175 dATP biosynthetic process is_a GO:0009153;GO:0009202;GO:0009216;GO:0046060 WAS GO:0009153;GO:0009216;GO:0046060 biological_process GO:0006185 dGDP biosynthetic process is_a GO:0009153;GO:0009183;GO:0009189;GO:0046066 WAS GO:0009153;GO:0009183;GO:0046066 biological_process GO:0006203 dGTP catabolic process is_a GO:0009155;GO:0009204;GO:0009217;GO:0046070 WAS GO:0009155;GO:0009217;GO:0046070 biological_process GO:0006227 dUDP biosynthetic process is_a GO:0009189;GO:0009197;GO:0009221;GO:0046077 WAS GO:0009197;GO:0009221;GO:0046077 biological_process GO:0006229 dUTP biosynthetic process is_a GO:0009202;GO:0009212;GO:0009221;GO:0046080 WAS GO:0009212;GO:0009221;GO:0046080 biological_process GO:0006235 dTTP biosynthetic process is_a GO:0009202;GO:0009212;GO:0009221;GO:0046075 WAS GO:0009212;GO:0009221;GO:0046075 biological_process GO:0006240 dCDP biosynthetic process is_a GO:0009189;GO:0009197;GO:0009221;GO:0046062 WAS GO:0009197;GO:0009221;GO:0046062 biological_process GO:0006242 dCTP biosynthetic process is_a GO:0009202;GO:0009212;GO:0009221;GO:0046065 WAS GO:0009212;GO:0009221;GO:0046065 biological_process GO:0006251 dCDP catabolic process is_a GO:0009192;GO:0009198;GO:0009223;GO:0046062 WAS GO:0009198;GO:0009223;GO:0046062 biological_process GO:0006253 dCTP catabolic process is_a GO:0009204;GO:0009213;GO:0009223;GO:0046065 WAS GO:0009213;GO:0009223;GO:0046065 biological_process GO:0006257 dUDP catabolic process is_a GO:0009192;GO:0009198;GO:0009223;GO:0046077 WAS GO:0009198;GO:0009223;GO:0046077 biological_process GO:0006523 alanine biosynthetic process is_a GO:0008652;GO:0046394 WAS GO:1901607 biological_process GO:0006525 arginine metabolic process is_a GO:0006520;GO:0019752 WAS GO:1901605 biological_process GO:0006530 L-asparagine catabolic process is_a GO:0170035;GO:0170040 WAS GO:0006528;GO:0170035;GO:0170040 biological_process GO:0006531 aspartate metabolic process is_a GO:0006520;GO:0043648 WAS GO:0043648;GO:1901605 biological_process GO:0006536 glutamate metabolic process is_a GO:0006520;GO:0043648 WAS GO:0043648;GO:1901605 biological_process GO:0006544 glycine metabolic process is_a GO:0170039 WAS GO:0170039;GO:1901605 biological_process GO:0006546 glycine catabolic process is_a GO:0006544;GO:0009063;GO:0170040 WAS GO:0006544;GO:0170040;GO:1901606 biological_process GO:0006550 L-isoleucine catabolic process is_a GO:0009083;GO:0170035;GO:0170040 WAS GO:0006549;GO:0009083;GO:0170035;GO:0170040 biological_process GO:0006559 L-phenylalanine catabolic process is_a GO:0009074;GO:0170035;GO:0170040 WAS GO:0006558;GO:0009074;GO:0170035;GO:0170040 biological_process GO:0006566 L-threonine metabolic process is_a GO:0170033;GO:0170039 WAS GO:0019752 biological_process GO:0006569 L-tryptophan catabolic process is_a GO:0009074;GO:0042436;GO:0170035;GO:0170040 WAS GO:0006568;GO:0009074;GO:0042436;GO:0170035;GO:0170040 biological_process GO:0006571 L-tyrosine biosynthetic process is_a GO:0009073;GO:1902223 WAS GO:0006570;GO:0009073;GO:1902223 biological_process GO:0006572 L-tyrosine catabolic process is_a GO:0009074;GO:0170035;GO:0170040 WAS GO:0006570;GO:0009074;GO:0170035;GO:0170040 biological_process GO:0006574 L-valine catabolic process is_a GO:0009083;GO:0170035;GO:0170040 WAS GO:0006573;GO:0009083;GO:0170035;GO:0170040 biological_process GO:0006583 melanin biosynthetic process from tyrosine is_a GO:0042438 WAS GO:0006570;GO:0042438 biological_process GO:0006585 dopamine biosynthetic process from tyrosine is_a GO:0042416 WAS GO:0006570;GO:0042416 biological_process GO:0006591 ornithine metabolic process is_a GO:0170041 WAS GO:0170041;GO:1901605 biological_process GO:0006592 L-ornithine biosynthetic process is_a GO:0006591;GO:0008652;GO:0170043 WAS GO:0006591;GO:0170043;GO:1901607 biological_process GO:0006603 phosphocreatine metabolic process is_a GO:0006575;GO:0019637 WAS GO:0006575;GO:0006796;GO:0019637 biological_process GO:0006644 phospholipid metabolic process is_a GO:0006629;GO:0019637 WAS GO:0006629;GO:0006796;GO:0019637 biological_process GO:0006753 nucleoside phosphate metabolic process is_a GO:0019637;GO:0055086 WAS GO:0006796;GO:0019637;GO:0055086 biological_process GO:0006796 phosphate-containing compound metabolic process is_a GO:0008152 WAS GO:0006793 biological_process GO:0006868 L-glutamine transport is_a GO:0015804;GO:0015807 WAS GO:0015695;GO:0015804;GO:0015807 biological_process GO:0007023 post-chaperonin tubulin folding pathway is_a GO:0007021 WAS GO:0006457 biological_process GO:0008153 4-aminobenzoate biosynthetic process is_a GO:0008652;GO:0009073;GO:0042537;GO:0072330 WAS GO:0008652;GO:0009073;GO:0046482;GO:0072330 biological_process GO:0008612 peptidyl-hypusine biosynthetic process is_a GO:0009058;GO:0051604 WAS GO:0018205;GO:0051604;GO:1901607 biological_process GO:0009070 serine family amino acid biosynthetic process is_a GO:0008652;GO:0046394 WAS GO:1901607 biological_process GO:0009090 L-homoserine biosynthetic process is_a GO:0009092;GO:0170034;GO:0170043 WAS GO:0009070;GO:0009092;GO:0170034;GO:0170043 biological_process GO:0009094 L-phenylalanine biosynthetic process is_a GO:0009073;GO:1902223 WAS GO:0006558;GO:0009073;GO:1902223 biological_process GO:0009099 L-valine biosynthetic process is_a GO:0009079;GO:0009082 WAS GO:0006573;GO:0009079;GO:0009082 relationship N/A WAS has_part GO:0003984;has_part GO:0004160;has_part GO:0004455;has_part GO:0052655 biological_process GO:0009183 purine deoxyribonucleoside diphosphate biosynthetic process is_a GO:0009136;GO:0009182 WAS GO:0009136;GO:0009182;GO:0009189 biological_process GO:0009184 purine deoxyribonucleoside diphosphate catabolic process is_a GO:0009137;GO:0009182 WAS GO:0009137;GO:0009182;GO:0009192 biological_process GO:0009189 deoxyribonucleoside diphosphate biosynthetic process is_a GO:0006793;GO:0009058 WAS GO:0009133 biological_process GO:0009192 deoxyribonucleoside diphosphate catabolic process is_a GO:0006793;GO:0009056 WAS GO:0009134 biological_process GO:0009197 pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a GO:0009139;GO:0009196 WAS GO:0009139;GO:0009189;GO:0009196 biological_process GO:0009198 pyrimidine deoxyribonucleoside diphosphate catabolic process is_a GO:0009140;GO:0009196 WAS GO:0009140;GO:0009192;GO:0009196 biological_process GO:0009200 deoxyribonucleoside triphosphate metabolic process is_a GO:0009394 WAS GO:0009141 biological_process GO:0009202 deoxyribonucleoside triphosphate biosynthetic process is_a GO:0009200;GO:0009265 WAS GO:0009142;GO:0009200 biological_process GO:0009204 deoxyribonucleoside triphosphate catabolic process is_a GO:0009166;GO:0009200;GO:0046386 WAS GO:0009143;GO:0009200 biological_process GO:0009215 purine deoxyribonucleoside triphosphate metabolic process is_a GO:0009144 WAS GO:0009144;GO:0009200 biological_process GO:0009216 purine deoxyribonucleoside triphosphate biosynthetic process is_a GO:0009145;GO:0009215 WAS GO:0009145;GO:0009202;GO:0009215 biological_process GO:0009217 purine deoxyribonucleoside triphosphate catabolic process is_a GO:0009146;GO:0009215 WAS GO:0009146;GO:0009204;GO:0009215 biological_process GO:0009449 GABA biosynthetic process is_a GO:0008652;GO:0170043 WAS GO:0008652;GO:0009448;GO:0170043 biological_process GO:0009450 GABA catabolic process is_a GO:0009063;GO:0170044 WAS GO:0009063;GO:0009448;GO:0170044 biological_process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway is_a GO:0008654;GO:0016114;GO:0045338;GO:1902767 WAS GO:0045337;GO:1902767 biological_process GO:0010786 clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting relationship part_of GO:0006895 WAS part_of GO:0048203 biological_process GO:0010787 COPI coating of Golgi vesicle, inter-Golgi cisterna relationship part_of GO:0048219 WAS part_of GO:0048204 biological_process GO:0010788 COPI coating of Golgi vesicle, cis-Golgi to rough ER relationship part_of GO:0006890 WAS part_of GO:0048206 biological_process GO:0010920 negative regulation of inositol phosphate biosynthetic process is_a GO:0010563;GO:0010919;GO:0045912;GO:1902931 WAS GO:0010919;GO:0045912;GO:0045936;GO:1902931 biological_process GO:0014046 dopamine secretion is_a GO:0023061;GO:0050432 WAS GO:0015872;GO:0023061;GO:0050432 biological_process GO:0015685 ferric-enterobactin import into cell is_a GO:0033214 WAS GO:0015711;GO:0033214 biological_process GO:0015701 bicarbonate transport is_a GO:0006810 WAS GO:0015711 biological_process GO:0015728 mevalonate transport is_a GO:0015718;GO:0015850 WAS GO:0006810 biological_process GO:0015747 urate transport is_a GO:0071705 WAS GO:0015711;GO:0071705 biological_process GO:0015760 glucose-6-phosphate transport is_a GO:0015712 WAS GO:0015711;GO:0015712 biological_process GO:0015782 CMP-N-acetylneuraminate transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:0015786 UDP-glucose transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:0015789 UDP-N-acetylgalactosamine transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:0015790 UDP-xylose transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:0015794 glycerol-3-phosphate transmembrane transport is_a GO:0015748;GO:0055085;GO:1901264 WAS GO:0015711;GO:0015748;GO:0055085;GO:1901264 biological_process GO:0015805 S-adenosyl-L-methionine transport is_a GO:0072348 WAS GO:0015695;GO:0072348 biological_process GO:0015816 glycine transport is_a GO:0015804;GO:0046942;GO:0071705 WAS GO:0015695;GO:0015804;GO:0046942;GO:0071705 biological_process GO:0015820 L-leucine transport is_a GO:0015803;GO:0015804;GO:0015807 WAS GO:0015695;GO:0015803;GO:0015804;GO:0015807 biological_process GO:0015821 methionine transport is_a GO:0000101;GO:0006865 WAS GO:0000101;GO:0006865;GO:0015695 biological_process GO:0015822 ornithine transport is_a GO:0006865;GO:0046942;GO:0071705 WAS GO:0006865;GO:0015695;GO:0046942;GO:0071705 biological_process GO:0015824 proline transport is_a GO:0015804;GO:0015807 WAS GO:0015695;GO:0015804;GO:0015807 biological_process GO:0015827 tryptophan transport is_a GO:0006865;GO:0015801 WAS GO:0006865;GO:0015695;GO:0015801 biological_process GO:0015828 tyrosine transport is_a GO:0015801;GO:0015807 WAS GO:0015695;GO:0015801;GO:0015807 biological_process GO:0015839 cadaverine transport is_a GO:0071705 WAS GO:0015695;GO:0071705 biological_process GO:0015843 methylammonium transport is_a GO:0015837;GO:0019755 WAS GO:0015695;GO:0015837;GO:0019755 biological_process GO:0015847 putrescine transport is_a GO:0015846 WAS GO:0015695;GO:0015846 biological_process GO:0015848 spermidine transport is_a GO:0015846 WAS GO:0015695;GO:0015846 biological_process GO:0015866 ADP transport is_a GO:0015868;GO:0051503 WAS GO:0015711;GO:0015868;GO:0051503 biological_process GO:0015867 ATP transport is_a GO:0015868;GO:0051503 WAS GO:0015711;GO:0015868;GO:0051503 biological_process GO:0015870 acetylcholine transport is_a GO:0071705;GO:1901374 WAS GO:0015695;GO:0071705;GO:1901374 biological_process GO:0015871 choline transport is_a GO:0071705 WAS GO:0015695;GO:0071705 biological_process GO:0015879 carnitine transport is_a GO:0015838 WAS GO:0015695;GO:0015838 biological_process GO:0015880 coenzyme A transport is_a GO:0015748;GO:0015931;GO:0072348 WAS GO:0015711;GO:0015748;GO:0015931;GO:0072348 biological_process GO:0015883 FAD transport is_a GO:0006862 WAS GO:0006862;GO:0015711 biological_process GO:0015888 thiamine transport is_a GO:0051180;GO:0071705;GO:0072348 WAS GO:0015695;GO:0051180;GO:0071705;GO:0072348 biological_process GO:0015904 tetracycline transmembrane transport is_a GO:0015850;GO:0055085 WAS GO:0015711;GO:0015850;GO:0055085 biological_process GO:0015916 fatty-acyl-CoA transport is_a GO:0015748;GO:0015931;GO:1901337 WAS GO:0015711;GO:0015748;GO:0015931;GO:1901337 biological_process GO:0016261 L-selenocysteine catabolic process is_a GO:0042219;GO:0170035;GO:0170040 WAS GO:1901606 biological_process GO:0018926 methanesulfonic acid metabolic process is_a GO:0006805;GO:0019694;GO:0044281 WAS GO:0006805;GO:0019694 biological_process GO:0018963 phthalate metabolic process is_a GO:0042537;GO:0043648 WAS GO:0019752;GO:0042537 biological_process GO:0018984 naphthalenesulfonate metabolic process is_a GO:0006790 WAS GO:0006082;GO:0006790 biological_process GO:0019240 L-citrulline biosynthetic process is_a GO:0008652;GO:0170043 WAS GO:0000052;GO:0170043;GO:1901607 biological_process GO:0019241 L-citrulline catabolic process is_a GO:0009063;GO:0170044 WAS GO:0000052;GO:0170044;GO:1901606 biological_process GO:0019255 glucose 1-phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0019295 coenzyme M biosynthetic process is_a GO:0044272 WAS GO:0016053;GO:0044272 biological_process GO:0019339 parathion catabolic process is_a GO:0044273;GO:0046434 WAS GO:0006796;GO:0044273;GO:0046434 biological_process GO:0019350 teichoic acid biosynthetic process is_a GO:0044038;GO:0044283;GO:0046374;GO:1901137 WAS GO:0016053;GO:0044038;GO:0046374;GO:1901137 biological_process GO:0019478 D-amino acid catabolic process is_a GO:0009063;GO:0046416;GO:0170044 WAS GO:0046416;GO:0170044;GO:1901606 biological_process GO:0019483 beta-alanine biosynthetic process is_a GO:0008652;GO:0170043 WAS GO:0008652;GO:0019482;GO:0170043 biological_process GO:0019484 beta-alanine catabolic process is_a GO:0009063;GO:0170044 WAS GO:0009063;GO:0019482;GO:0170044 biological_process GO:0019524 keto-D-gluconate catabolic process is_a GO:0046176 WAS GO:0046181 biological_process GO:0019578 aldaric acid biosynthetic process is_a GO:0046394 WAS GO:0043650 biological_process GO:0019579 aldaric acid catabolic process is_a GO:0046395 WAS GO:0043649 biological_process GO:0019664 mixed acid fermentation is_a GO:0006067;GO:0006083;GO:0006089;GO:0006103;GO:0006105;GO:0015942;GO:0046434;GO:0072329 WAS GO:0006067;GO:0006083;GO:0006089;GO:0006103;GO:0006105;GO:0006796;GO:0015942;GO:0046434;GO:0072329 biological_process GO:0019682 glyceraldehyde-3-phosphate metabolic process is_a GO:0006081;GO:0019637;GO:1901135 WAS GO:0006081;GO:0006796;GO:0019637;GO:1901135 biological_process GO:0019693 ribose phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0019694 alkanesulfonate metabolic process is_a GO:0006790 WAS GO:0006082;GO:0006790 biological_process GO:0030150 protein import into mitochondrial matrix is_a GO:0044743;GO:0070585;GO:0170036;GO:7770058 WAS GO:0010496;GO:0070585;GO:0071806;GO:0072594 biological_process GO:0030388 fructose 1,6-bisphosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0030645 acetyl-CoA fermentation to butanoate is_a GO:0006113;GO:0019605;GO:0046356 WAS GO:0019605;GO:0046356 relationship N/A WAS part_of GO:0006113 biological_process GO:0030974 thiamine pyrophosphate transmembrane transport is_a GO:0015697;GO:0015748;GO:0071934 WAS GO:0015697;GO:0015711;GO:0015748;GO:0071934 biological_process GO:0031140 induction of conjugation upon nutrient starvation is_a GO:0031139 WAS GO:0010514 biological_process GO:0031460 glycine betaine transport is_a GO:0015838 WAS GO:0015695;GO:0015838 biological_process GO:0031920 pyridoxal transport is_a GO:0015850;GO:0031919 WAS GO:0015695;GO:0015850;GO:0031919 biological_process GO:0031921 pyridoxal phosphate transport is_a GO:0015748;GO:0015850;GO:0031919 WAS GO:0015711;GO:0015748;GO:0015850;GO:0031919 biological_process GO:0031922 pyridoxamine transport is_a GO:0015850;GO:0031919 WAS GO:0015695;GO:0015850;GO:0031919 biological_process GO:0032218 riboflavin transport is_a GO:0051180;GO:0071705 WAS GO:0015711;GO:0051180;GO:0071705 biological_process GO:0032274 gonadotropin secretion is_a GO:0046879 WAS GO:0060986 biological_process GO:0032328 alanine transport is_a GO:0015804;GO:0046942;GO:0071705 WAS GO:0015695;GO:0015804;GO:0046942;GO:0071705 biological_process GO:0032329 serine transport is_a GO:0015804;GO:0046942;GO:0071705 WAS GO:0015695;GO:0015804;GO:0046942;GO:0071705 biological_process GO:0032334 inhibin secretion is_a GO:0046879 WAS GO:0060986 biological_process GO:0032979 protein insertion into mitochondrial inner membrane from matrix is_a GO:0007007;GO:0051204 WAS GO:0045039 biological_process GO:0033215 reductive iron assimilation is_a GO:0098711 WAS GO:0033212 biological_process GO:0033272 myo-inositol hexakisphosphate transport is_a GO:0033271 WAS GO:0015711;GO:0033271 biological_process GO:0033353 L-methionine cycle is_a GO:0006555;GO:0006575;GO:0046128;GO:0046500;GO:0050667 WAS GO:0046500 biological_process GO:0033499 beta-D-galactose catabolic process via UDP-galactose, Leloir pathway is_a GO:0019388;GO:0019637;GO:1901135 WAS GO:0006796;GO:0019388;GO:0046434;GO:1901136 biological_process GO:0034194 D-galactonate catabolic process is_a GO:0016052;GO:0046176 WAS GO:0016052;GO:0019584 biological_process GO:0034195 L-galactonate catabolic process is_a GO:0016052;GO:0046176 WAS GO:0016052;GO:0019584 biological_process GO:0034229 ethanolamine transport is_a GO:0015837;GO:0015850 WAS GO:0015695;GO:0015837;GO:0015850 biological_process GO:0034254 regulation of urea catabolic process is_a GO:0009894;GO:0062012 WAS GO:0009894;GO:0062012;GO:1903314 biological_process GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan is_a GO:0009072;GO:0009435;GO:0042430;GO:0170033;GO:0170039 WAS GO:0006568;GO:0009435 biological_process GO:0034635 glutathione transport is_a GO:0042939;GO:0072337;GO:0072348 WAS GO:0015711;GO:0042939;GO:0072337;GO:0072348 biological_process GO:0035303 regulation of dephosphorylation is_a GO:0019222 WAS GO:0051174 biological_process GO:0035429 gluconate transmembrane transport is_a GO:0034219;GO:0042873 WAS GO:0042873 biological_process GO:0035436 triose phosphate transmembrane transport is_a GO:0015717;GO:0055085 WAS GO:0015711;GO:0015717;GO:0055085 biological_process GO:0035674 tricarboxylic acid transmembrane transport is_a GO:0006842;GO:1905039 WAS GO:1905039 biological_process GO:0035863 dITP catabolic process is_a GO:0009155;GO:0009204;GO:0009217 WAS GO:0009155;GO:0009217 biological_process GO:0035898 parathyroid hormone secretion is_a GO:0046879 WAS GO:0060986 biological_process GO:0035929 steroid hormone secretion is_a GO:0046879;GO:0140353 WAS GO:0060986;GO:0140353 biological_process GO:0035964 COPI-coated vesicle budding relationship part_of GO:0048193 WAS part_of GO:0048199 biological_process GO:0038060 nitric oxide-cGMP-mediated signaling is_a GO:0141124 WAS GO:0007263 biological_process GO:0042217 1-aminocyclopropane-1-carboxylate catabolic process is_a GO:0009063;GO:0170044 WAS GO:0170044;GO:1901606 biological_process GO:0042325 regulation of phosphorylation is_a GO:0019222 WAS GO:0051174 biological_process GO:0042357 thiamine diphosphate metabolic process is_a GO:0019637;GO:0042723 WAS GO:0006796;GO:0019637;GO:0042723 biological_process GO:0042396 phosphagen biosynthetic process is_a GO:0042398;GO:0090407 WAS GO:0006796;GO:0042398;GO:0090407 biological_process GO:0042397 phosphagen catabolic process is_a GO:0042219;GO:0046434 WAS GO:0006796;GO:0042219;GO:0046434 biological_process GO:0042618 poly-hydroxybutyrate metabolic process is_a GO:0008152 WAS GO:1901440 biological_process GO:0042619 poly-hydroxybutyrate biosynthetic process is_a GO:0009058;GO:0042618 WAS GO:0042618;GO:1901441 biological_process GO:0042816 vitamin B6 metabolic process is_a GO:0006766;GO:0072524 WAS GO:0072524 biological_process GO:0042822 pyridoxal 5'-phosphate metabolic process is_a GO:0006081;GO:0019637;GO:0042816 WAS GO:0006081;GO:0006796;GO:0019637;GO:0042816 biological_process GO:0042836 D-glucarate metabolic process is_a GO:0005975;GO:0019752 WAS GO:0005975;GO:0043648 biological_process GO:0042837 D-glucarate biosynthetic process is_a GO:0016051;GO:0019578;GO:0042836 WAS GO:0016051;GO:0019393;GO:0042836 biological_process GO:0042869 aldarate transmembrane transport is_a GO:1905039 WAS GO:0006835;GO:1905039 biological_process GO:0042883 L-cysteine transport is_a GO:0000101;GO:0015804;GO:0015807 WAS GO:0000101;GO:0015695;GO:0015804 biological_process GO:0042918 alkanesulfonate transmembrane transport is_a GO:0015849;GO:0055085;GO:0072348 WAS GO:0015711;GO:0015849;GO:0055085;GO:0072348 biological_process GO:0042930 enterobactin transport is_a GO:0015850;GO:0015891 WAS GO:0015711;GO:0015850;GO:0015891 biological_process GO:0043215 daunorubicin transport is_a GO:0071705;GO:1901656 WAS GO:0015695;GO:0071705;GO:1901656 biological_process GO:0043251 sodium-dependent organic anion transport is_a GO:0055085 WAS GO:0015711 biological_process GO:0043252 sodium-independent organic anion transport is_a GO:0055085 WAS GO:0015711 biological_process GO:0043436 oxoacid metabolic process is_a GO:0044281 WAS GO:0006082 biological_process GO:0043545 molybdopterin cofactor metabolic process is_a GO:0019637;GO:0051189 WAS GO:0006796;GO:0019637;GO:0051189 biological_process GO:0043647 inositol phosphate metabolic process is_a GO:0019637;GO:0019751 WAS GO:0006796;GO:0019637;GO:0019751 biological_process GO:0045039 protein insertion into mitochondrial inner membrane is_a GO:0007007;GO:7770058 WAS GO:0007007;GO:0051204 biological_process GO:0045041 protein import into mitochondrial intermembrane space is_a GO:7770058 WAS GO:0010496;GO:0070585;GO:0071806;GO:0072594 biological_process GO:0045337 trans, trans-farnesyl diphosphate biosynthetic process is_a GO:0008654;GO:0016114;GO:0045338;GO:0050993 WAS GO:0008654;GO:0016114;GO:0045338 biological_process GO:0045443 juvenile hormone secretion is_a GO:0046865;GO:0046879;GO:0140353 WAS GO:0046865;GO:0060986;GO:0140353 biological_process GO:0045936 negative regulation of phosphate metabolic process is_a GO:0009892 WAS GO:0010563 biological_process GO:0045937 positive regulation of phosphate metabolic process is_a GO:0009893 WAS GO:0010562 biological_process GO:0045980 negative regulation of nucleotide metabolic process is_a GO:0006140;GO:0010563;GO:0045934;GO:0062014 WAS GO:0006140;GO:0045934;GO:0045936;GO:0062014 biological_process GO:0045981 positive regulation of nucleotide metabolic process is_a GO:0006140;GO:0010562;GO:0062013 WAS GO:0006140;GO:0045937;GO:0062013 biological_process GO:0046057 dADP catabolic process is_a GO:0009155;GO:0009184;GO:0009192;GO:0046056 WAS GO:0009155;GO:0009184;GO:0046056 biological_process GO:0046060 dATP metabolic process is_a GO:0009151;GO:0009200;GO:0009215 WAS GO:0009151;GO:0009215 biological_process GO:0046061 dATP catabolic process is_a GO:0009155;GO:0009204;GO:0009217;GO:0046060 WAS GO:0009155;GO:0009217;GO:0046060 biological_process GO:0046065 dCTP metabolic process is_a GO:0009200;GO:0009211;GO:0009219 WAS GO:0009211;GO:0009219 biological_process GO:0046067 dGDP catabolic process is_a GO:0009155;GO:0009184;GO:0009192;GO:0046066 WAS GO:0009155;GO:0009184;GO:0046066 biological_process GO:0046070 dGTP metabolic process is_a GO:0009151;GO:0009200;GO:0009215 WAS GO:0009151;GO:0009215 biological_process GO:0046071 dGTP biosynthetic process is_a GO:0009153;GO:0009202;GO:0009216;GO:0046070 WAS GO:0009153;GO:0009216;GO:0046070 biological_process GO:0046075 dTTP metabolic process is_a GO:0009200;GO:0009211;GO:0009219 WAS GO:0009211;GO:0009219 biological_process GO:0046076 dTTP catabolic process is_a GO:0009204;GO:0009213;GO:0009223;GO:0046075 WAS GO:0009213;GO:0009223;GO:0046075 biological_process GO:0046080 dUTP metabolic process is_a GO:0009200;GO:0009211;GO:0009219 WAS GO:0009211;GO:0009219 biological_process GO:0046081 dUTP catabolic process is_a GO:0009204;GO:0009213;GO:0009223;GO:0046080 WAS GO:0009213;GO:0009223;GO:0046080 biological_process GO:0046179 keto-D-gluconate biosynthetic process is_a GO:0046175 WAS GO:0046180 biological_process GO:0046230 2-aminobenzenesulfonate catabolic process is_a GO:0009310;GO:0042178;GO:0042537;GO:0044273 WAS GO:0009310;GO:0016054;GO:0042178;GO:0042537;GO:0044273 biological_process GO:0046239 phthalate catabolic process is_a GO:0018963;GO:0042178;GO:0043649 WAS GO:0018963;GO:0042178;GO:0046395 biological_process GO:0046269 toluene-4-sulfonate catabolic process is_a GO:0044273;GO:0044282;GO:0072491 WAS GO:0016054;GO:0044273;GO:0072491 biological_process GO:0046305 alkanesulfonate biosynthetic process is_a GO:0019694;GO:0044272 WAS GO:0016053;GO:0019694;GO:0044272 biological_process GO:0046306 alkanesulfonate catabolic process is_a GO:0019694;GO:0044273 WAS GO:0016054;GO:0019694;GO:0044273 biological_process GO:0046357 D-galactarate biosynthetic process is_a GO:0016051;GO:0019578;GO:0019580;GO:0043650 WAS GO:0016051;GO:0019578;GO:0019580 biological_process GO:0046385 deoxyribose phosphate biosynthetic process is_a GO:0090407;GO:1901137 WAS GO:0006796;GO:0090407;GO:1901137 biological_process GO:0046386 deoxyribose phosphate catabolic process is_a GO:0046434;GO:1901136 WAS GO:0006796;GO:0046434;GO:1901136 biological_process GO:0046392 D-galactarate catabolic process is_a GO:0016052;GO:0019579;GO:0019580;GO:0043649 WAS GO:0016052;GO:0019579;GO:0019580 biological_process GO:0046394 carboxylic acid biosynthetic process is_a GO:0019752;GO:0044283 WAS GO:0016053;GO:0019752 biological_process GO:0046395 carboxylic acid catabolic process is_a GO:0019752;GO:0044282 WAS GO:0016054;GO:0019752 biological_process GO:0046416 D-amino acid metabolic process is_a GO:0170041 WAS GO:0170041;GO:1901605 biological_process GO:0046437 D-amino acid biosynthetic process is_a GO:0008652;GO:0046416;GO:0170043 WAS GO:0046416;GO:0170043;GO:1901607 biological_process GO:0046942 carboxylic acid transport is_a GO:0015849 WAS GO:0015711;GO:0015849 biological_process GO:0046951 ketone body biosynthetic process is_a GO:0044283;GO:1901570 WAS GO:0044283;GO:1901570;GO:1902224 biological_process GO:0046952 ketone body catabolic process is_a GO:0044282;GO:1901569 WAS GO:0044282;GO:1901569;GO:1902224 biological_process GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport is_a GO:0015868;GO:0051503;GO:0072348 WAS GO:0015711;GO:0015868;GO:0051503;GO:0072348 biological_process GO:0048200 Golgi transport vesicle coating relationship part_of GO:0048194 WAS part_of GO:0048194;part_of GO:0048199 biological_process GO:0048208 COPII vesicle coat assembly relationship part_of GO:0090114 WAS part_of GO:0048207;part_of GO:0090114 biological_process GO:0048242 epinephrine secretion is_a GO:0050432 WAS GO:0048241;GO:0050432 biological_process GO:0048243 norepinephrine secretion is_a GO:0023061;GO:0050432 WAS GO:0015874;GO:0023061;GO:0050432 biological_process GO:0050432 catecholamine secretion is_a GO:0015850;GO:0032940;GO:0071705 WAS GO:0032940;GO:0051937 biological_process GO:0050667 homocysteine metabolic process is_a GO:0000096;GO:0170041 WAS GO:0000096;GO:0170041;GO:1901605 biological_process GO:0050845 teichuronic acid biosynthetic process is_a GO:0044038;GO:0044283 WAS GO:0016053;GO:0044038 biological_process GO:0051156 glucose 6-phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0051167 D-xylulose 5-phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0051458 corticotropin secretion is_a GO:0030072 WAS GO:0030072;GO:0060986 biological_process GO:0051610 serotonin uptake is_a GO:0015850;GO:0071705;GO:0098810 WAS GO:0006837;GO:0098810 biological_process GO:0051620 norepinephrine uptake is_a GO:0090493 WAS GO:0015874;GO:0090493 biological_process GO:0052646 alditol phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:0052699 ergothioneine biosynthetic process is_a GO:0000097;GO:0006578;GO:0052703 WAS GO:0000097;GO:0006578;GO:0052698;GO:0052703 biological_process GO:0052700 ergothioneine catabolic process is_a GO:0000098;GO:0006579;GO:0052702 WAS GO:0000098;GO:0006579;GO:0052698;GO:0052702 biological_process GO:0060271 cilium assembly relationship has_part GO:0035082;has_part GO:0035735;has_part GO:0061512;has_part GO:0097712;has_part GO:1905349 WAS has_part GO:0035082;has_part GO:0035735;has_part GO:0061512;has_part GO:0097711;has_part GO:0097712;has_part GO:1905349 biological_process GO:0060304 regulation of phosphatidylinositol dephosphorylation is_a GO:0019216;GO:0035303;GO:0051174;GO:0060255 WAS GO:0019216;GO:0035303;GO:0060255 biological_process GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process is_a GO:0010562 WAS GO:0045937 biological_process GO:0060732 positive regulation of inositol phosphate biosynthetic process is_a GO:0010562;GO:0010919;GO:0045913;GO:1902932 WAS GO:0010919;GO:0045913;GO:0045937;GO:1902932 biological_process GO:0061538 histamine secretion, neurotransmission is_a GO:0001821;GO:0007269;GO:0015801;GO:0015807 WAS GO:0001821;GO:0007269;GO:0015695;GO:0015801;GO:0015807 biological_process GO:0061545 tyramine secretion is_a GO:0015850;GO:0061531 WAS GO:0061531;GO:7770032 biological_process GO:0061621 canonical glycolysis is_a GO:0006007;GO:0061620 WAS GO:0061620;GO:0061718 biological_process GO:0061625 glycolytic process through fructose-1-phosphate is_a GO:0006096 WAS GO:0006001;GO:0006096 relationship N/A WAS has_part GO:0004807;has_part GO:0061624 biological_process GO:0061633 transport-coupled glycolytic process through glucose-6-phosphate is_a GO:0006007;GO:0061620 WAS GO:0061620;GO:0061718 biological_process GO:0061706 glycolytic process from sucrose through glucose and fructose is_a GO:0061704 WAS GO:0061615;GO:0061704 relationship N/A WAS has_part GO:0061705 biological_process GO:0061722 sulphoglycolysis is_a GO:0006091;GO:1902777 WAS GO:0006090;GO:0006091;GO:0046034;GO:0046496;GO:1902777 relationship N/A WAS has_part GO:0004365;has_part GO:0004618;has_part GO:0004619;has_part GO:0004634;has_part GO:0004743;has_part GO:0004807;has_part GO:0061720 biological_process GO:0062089 regulation of taurine biosynthetic process is_a GO:0009889;GO:0042762 WAS GO:0009889;GO:0042762;GO:0062012 biological_process GO:0062090 positive regulation of taurine biosynthetic process is_a GO:0009891;GO:0062089 WAS GO:0009891;GO:0062013;GO:0062089 biological_process GO:0070162 adiponectin secretion is_a GO:0009306;GO:0046879 WAS GO:0009306;GO:0060986 biological_process GO:0070408 carbamoyl phosphate metabolic process is_a GO:0019637 WAS GO:0006796;GO:0019637 biological_process GO:0070617 negative regulation of thiamine diphosphate biosynthetic process is_a GO:0009890;GO:0010563;GO:0046137;GO:0070616 WAS GO:0009890;GO:0045936;GO:0046137;GO:0070616 biological_process GO:0070715 sodium-dependent organic cation transport is_a GO:0055085 WAS GO:0015695 biological_process GO:0070730 cAMP transport is_a GO:0015868;GO:0051503;GO:0070729 WAS GO:0015711;GO:0015868;GO:0051503;GO:0070729 biological_process GO:0070731 cGMP transport is_a GO:0001408;GO:0015868;GO:0070729 WAS GO:0001408;GO:0015711;GO:0015868;GO:0070729 biological_process GO:0070811 glycerol-2-phosphate transmembrane transport is_a GO:0015748;GO:0055085;GO:1901264 WAS GO:0015711;GO:0015748;GO:0055085;GO:1901264 biological_process GO:0070837 dehydroascorbic acid transport is_a GO:0051180 WAS GO:0015711;GO:0051180 biological_process GO:0070981 L-asparagine biosynthetic process is_a GO:0009067 WAS GO:0006528;GO:0009067 biological_process GO:0071507 pheromone response MAPK cascade relationship part_of GO:0000747 WAS part_of GO:0000747;part_of GO:0000750 biological_process GO:0071800 podosome assembly is_a GO:0065003;GO:0120031 WAS GO:0065003;GO:0140694 biological_process GO:0071801 regulation of podosome assembly is_a GO:0043254;GO:0120032 WAS GO:0043254;GO:1902115 biological_process GO:0071802 negative regulation of podosome assembly is_a GO:0031333;GO:0071801;GO:0120033 WAS GO:0031333;GO:0071801;GO:1902116 biological_process GO:0071803 positive regulation of podosome assembly is_a GO:0031334;GO:0071801;GO:0120034 WAS GO:0031334;GO:0071801;GO:1902117 biological_process GO:0071993 phytochelatin transport is_a GO:0071705 WAS GO:0015711;GO:0071705 biological_process GO:0072318 clathrin coat disassembly relationship part_of GO:0072583 WAS N/A biological_process GO:0072334 UDP-galactose transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:0080121 AMP transport is_a GO:0015868;GO:0051503 WAS GO:0015695;GO:0015711;GO:0015868;GO:0051503 biological_process GO:0089709 L-histidine transmembrane transport is_a GO:0015801;GO:0045117;GO:1902475 WAS GO:0015695;GO:0015801;GO:0045117;GO:1902475 biological_process GO:0090352 regulation of nitrate assimilation is_a GO:0062012 WAS GO:0062012;GO:1903314 biological_process GO:0090493 catecholamine uptake is_a GO:0015850;GO:0071705 WAS GO:0051937 biological_process GO:0090494 dopamine uptake is_a GO:0090493 WAS GO:0015872;GO:0090493 biological_process GO:0097638 L-arginine import across plasma membrane is_a GO:0089718;GO:1903826 WAS GO:0015695;GO:0089718;GO:1902475 biological_process GO:0097712 trans-Golgi to periciliary membrane compartment transport is_a GO:0006893 WAS GO:0048199 biological_process GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process is_a GO:0009890;GO:0010563;GO:0045934;GO:0062014;GO:0106278 WAS GO:0009890;GO:0045934;GO:0045936;GO:0062014;GO:0106278 biological_process GO:0106280 positive regulation of UDP-N-acetylglucosamine biosynthetic process is_a GO:0009891;GO:0010562;GO:0062013;GO:0106278 WAS GO:0009891;GO:0045937;GO:0062013;GO:0106278 biological_process GO:0120575 L-dopa catabolic process is_a GO:0009074;GO:0042219;GO:0170035;GO:0170044 WAS GO:0009074;GO:0042219;GO:0170035;GO:0170044;GO:1903184 biological_process GO:0140270 gluconate import across plasma membrane is_a GO:0035429;GO:0098704 WAS GO:0035429;GO:0098739 biological_process GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane is_a GO:0015868;GO:0051503;GO:0070729;GO:0098739;GO:1903790 WAS GO:0015711;GO:0015868;GO:0051503;GO:0070729;GO:0098739;GO:1903790 biological_process GO:0140380 psilocybin biosynthetic process is_a GO:0009072;GO:0035835;GO:0042435;GO:0043386;GO:0090407;GO:0170033;GO:0170039 WAS GO:0006568;GO:0006796;GO:0035835;GO:0042435;GO:0043386;GO:0090407 biological_process GO:0140390 positive regulation of acetyl-CoA biosynthesis is_a GO:0009891;GO:0010562;GO:0050812;GO:0062013 WAS GO:0009891;GO:0045937;GO:0050812;GO:0062013 biological_process GO:0140391 negative regulation of acetyl-CoA biosynthesis is_a GO:0009890;GO:0010563;GO:0045934;GO:0050812;GO:0062014 WAS GO:0009890;GO:0045934;GO:0045936;GO:0050812;GO:0062014 biological_process GO:0140484 5-aminolevulinic acid import across plasma membrane is_a GO:0015718;GO:0071705;GO:0089718;GO:1905039 WAS GO:0015695;GO:0015718;GO:0071705;GO:0089718;GO:1905039 biological_process GO:0140493 very long-chain fatty acid beta-oxidation is_a GO:0042760 WAS GO:0033540;GO:0042760 biological_process GO:0140821 UDP-beta-L-arabinofuranose import into Golgi lumen is_a GO:0090481;GO:0140820 WAS GO:0015711;GO:0090481;GO:0140820 biological_process GO:0140925 L-phenylalanine import across plasma membrane is_a GO:0015801;GO:0015823;GO:0089718;GO:1902475 WAS GO:0015695;GO:0015801;GO:0015823;GO:0089718;GO:1902475 biological_process GO:0141149 regulation of nitric oxide-cGMP mediated signal transduction is_a GO:1902531 WAS GO:0010749 biological_process GO:0141150 positive regulation of nitric oxide-cGMP mediated signal transduction is_a GO:0141149;GO:1902533 WAS GO:0010750;GO:0141149 biological_process GO:0141151 negative regulation of nitric oxide-cGMP mediated signal transduction is_a GO:0141149;GO:1902532 WAS GO:0010751;GO:0141149 biological_process GO:0160131 sperm migration through the uterotubal junction relationship part_of GO:0048609 WAS has_part GO:0030317;part_of GO:0048609 biological_process GO:0160203 protein import into the intermembrane space via the disulfide relay system is_a GO:0045041 WAS GO:0006457 relationship N/A WAS part_of GO:0045041 biological_process GO:0160310 dopamine loading into synaptic vesicle is_a GO:0015842;GO:0015850 WAS GO:0015872;GO:0098700 biological_process GO:0160311 tyramine loading into synaptic vesicle is_a GO:0015842;GO:0015850 WAS GO:0098700;GO:7770032 biological_process GO:0160312 octopamine loading into synaptic vesicle is_a GO:0015842;GO:7770033 WAS GO:0098700;GO:7770033 biological_process GO:0170033 L-amino acid metabolic process is_a GO:0006520;GO:0019752 WAS GO:1901605 biological_process GO:0170034 L-amino acid biosynthetic process is_a GO:0008652;GO:0046394;GO:0170033 WAS GO:0170033;GO:1901607 biological_process GO:0170035 L-amino acid catabolic process is_a GO:0009063;GO:0046395;GO:0170033 WAS GO:0170033;GO:1901606 biological_process GO:0170046 isopentenyl pyrophosphate import into mitochondrion is_a GO:0015914;GO:0032365;GO:0170036 WAS GO:0015711;GO:0015914;GO:0032365;GO:0170036 biological_process GO:1900751 4-(trimethylammonio)butanoate transport is_a GO:0015838 WAS GO:0015695;GO:0015838 biological_process GO:1900753 doxorubicin transport is_a GO:0015850;GO:0071705;GO:1901656 WAS GO:0015695;GO:0015850;GO:0071705;GO:1901656 biological_process GO:1900867 sarcinapterin metabolic process is_a GO:0019637;GO:0042558;GO:0072350 WAS GO:0006796;GO:0019637;GO:0042558;GO:0072350 biological_process GO:1900972 negative regulation of sarcinapterin biosynthetic process is_a GO:0009890;GO:0010563;GO:0062014;GO:1900971 WAS GO:0009890;GO:0045936;GO:0062014;GO:1900971 biological_process GO:1900973 positive regulation of sarcinapterin biosynthetic process is_a GO:0009891;GO:0010562;GO:0062013;GO:1900971 WAS GO:0009891;GO:0045937;GO:0062013;GO:1900971 biological_process GO:1901111 actinorhodin catabolic process is_a GO:0046395 WAS GO:0043649 biological_process GO:1901112 actinorhodin biosynthetic process is_a GO:0046394 WAS GO:0043650 biological_process GO:1901128 gentamycin metabolic process is_a GO:0008152 WAS GO:0016137;GO:0019751 biological_process GO:1901129 gentamycin catabolic process is_a GO:0009056;GO:1901128 WAS GO:0030649;GO:0046174;GO:1901128 biological_process GO:1901130 gentamycin biosynthetic process is_a GO:0009058;GO:1901128 WAS GO:0030648;GO:0046173;GO:1901128 biological_process GO:1901276 tartrate catabolic process is_a GO:0016052;GO:0019579;GO:0043649;GO:1901275 WAS GO:0016052;GO:0019579;GO:1901275 biological_process GO:1901277 tartrate biosynthetic process is_a GO:0016051;GO:0019578;GO:0043650;GO:1901275 WAS GO:0016051;GO:0019578;GO:1901275 biological_process GO:1901284 5,6,7,8-tetrahydromethanopterin catabolic process is_a GO:0042560;GO:0043649;GO:0046434 WAS GO:0006796;GO:0042560;GO:0043649;GO:0046434 biological_process GO:1901369 cyclic 2,3-bisphospho-D-glycerate biosynthetic process is_a GO:0072330;GO:0090407;GO:1901137 WAS GO:0006796;GO:0072330;GO:0090407;GO:1901137 biological_process GO:1901705 L-isoleucine biosynthetic process is_a GO:0009067;GO:0009082 WAS GO:0006549;GO:0009067;GO:0009082 biological_process GO:1901713 negative regulation of urea catabolic process is_a GO:0009895;GO:0034254;GO:0062014 WAS GO:0009895;GO:0034254;GO:0062014;GO:1903315 biological_process GO:1901714 positive regulation of urea catabolic process is_a GO:0009896;GO:0034254;GO:0062013 WAS GO:0009896;GO:0034254;GO:0062013;GO:1903316 biological_process GO:1901854 5,6,7,8-tetrahydrosarcinapterin catabolic process is_a GO:0042560;GO:0046434;GO:0072352 WAS GO:0006796;GO:0042560;GO:0046434;GO:0072352 biological_process GO:1901997 negative regulation of indoleacetic acid biosynthetic process is_a GO:0010600;GO:0032353;GO:0062014;GO:0090356 WAS GO:0032353;GO:0045763;GO:0062014;GO:0090356;GO:1901996 relationship negatively_regulates GO:0009684 WAS negatively_regulates GO:0009848 intersection_of is_a GO:0065007;negatively_regulates GO:0009684 WAS is_a GO:0065007;negatively_regulates GO:0009848 biological_process GO:1902022 L-lysine transport is_a GO:0015807 WAS GO:0015695;GO:0015807 biological_process GO:1902024 L-histidine transport is_a GO:0015801;GO:0015802;GO:0015807 WAS GO:0015695;GO:0015801;GO:0015802;GO:0015807 biological_process GO:1902389 ceramide 1-phosphate transport is_a GO:0015914;GO:0035627 WAS GO:0015711;GO:0015914;GO:0035627 biological_process GO:1902558 5'-adenylyl sulfate transmembrane transport is_a GO:0015868;GO:0051503;GO:0072348;GO:0072530;GO:1901679 WAS GO:0015711;GO:0015868;GO:0051503;GO:0072348;GO:0072530;GO:1901679 biological_process GO:1902777 6-sulfoquinovose(1-) catabolic process is_a GO:0044273;GO:1901136 WAS GO:0016054;GO:0044273;GO:1901136 biological_process GO:1902921 poly(hydroxyvalerate) biosynthetic process is_a GO:0009058 WAS GO:1901441 biological_process GO:1903712 L-cysteine transmembrane transport is_a GO:0042883;GO:1902475 WAS GO:0003333;GO:0042883;GO:1905039 biological_process GO:1903726 negative regulation of phospholipid metabolic process is_a GO:0010563;GO:0045833;GO:1903725 WAS GO:0045833;GO:0045936;GO:1903725 biological_process GO:1903727 positive regulation of phospholipid metabolic process is_a GO:0010562;GO:0045834;GO:1903725 WAS GO:0045834;GO:0045937;GO:1903725 biological_process GO:1903785 L-valine transmembrane transport is_a GO:0015829;GO:1902475 WAS GO:0015695;GO:0015829;GO:1902475 biological_process GO:1903806 L-isoleucine import across plasma membrane is_a GO:0089718;GO:1902475;GO:1903714 WAS GO:0015695;GO:0089718;GO:1902475;GO:1903714 biological_process GO:1903807 L-threonine import across plasma membrane is_a GO:0015826;GO:0089718;GO:1902475 WAS GO:0015695;GO:0015826;GO:0089718;GO:1902475 biological_process GO:1903811 L-asparagine import across plasma membrane is_a GO:0006867;GO:0089718;GO:1902475;GO:1903713 WAS GO:0006867;GO:0015695;GO:0089718;GO:1902475;GO:1903713 biological_process GO:1903826 L-arginine transmembrane transport is_a GO:1902475;GO:1990822 WAS GO:0015695;GO:1902475;GO:1990822 biological_process GO:1904106 protein localization to microvillus is_a GO:1903119 WAS GO:0008104 biological_process GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate is_a GO:0045820 WAS GO:0045820;GO:1904538 biological_process GO:1904540 positive regulation of glycolytic process through fructose-6-phosphate is_a GO:0045821 WAS GO:0045821;GO:1904538 biological_process GO:1904600 mating projection actin fusion focus assembly is_a GO:0030036 WAS GO:0010927;GO:0030036 relationship part_of GO:0000755 WAS part_of GO:0031382 biological_process GO:1904601 protein transport to mating projection actin fusion focus relationship part_of GO:0000755 WAS N/A biological_process GO:1904959 regulation of cytochrome-c oxidase activity is_a GO:0010155;GO:0022898;GO:0051341 WAS GO:0010155;GO:0022898 biological_process GO:1904960 positive regulation of cytochrome-c oxidase activity is_a GO:0032414;GO:0051353;GO:1904959 WAS GO:0032414;GO:1904959 biological_process GO:1905130 carcinine import across plasma membrane is_a GO:0045117;GO:0072337;GO:0098739 WAS GO:0015695;GO:0045117;GO:0072337;GO:0098739 biological_process GO:1905329 sphingoid long-chain base transport is_a GO:0006869;GO:0071705 WAS GO:0006869;GO:0015695;GO:0071705 biological_process GO:1990569 UDP-N-acetylglucosamine transmembrane transport is_a GO:0090481 WAS GO:0015711;GO:0090481 biological_process GO:1990570 GDP-mannose transmembrane transport is_a GO:0090480 WAS GO:0015711;GO:0090480 biological_process GO:1990818 L-arginine transmembrane export from vacuole is_a GO:0032974;GO:1903826 WAS GO:0015695;GO:0032974;GO:1902475 biological_process GO:2001059 D-tagatose 6-phosphate catabolic process is_a GO:0046434;GO:1901136 WAS GO:0006796;GO:0046434;GO:1901136 biological_process GO:2001060 D-glycero-D-manno-heptose 7-phosphate metabolic process is_a GO:0019637;GO:1901135 WAS GO:0006796;GO:0019637;GO:1901135 biological_process GO:2001116 methanopterin-containing compound biosynthetic process is_a GO:0042559;GO:0090407 WAS GO:0006796;GO:0042559;GO:0090407 biological_process GO:2001143 N-methylnicotinate transport is_a GO:0015697 WAS GO:0015695;GO:0015697 biological_process GO:2001289 lipid X metabolic process is_a GO:0006040;GO:0019637 WAS GO:0006040;GO:0006796;GO:0019637 biological_process GO:7770033 octopamine transport is_a GO:0015850;GO:0071705 WAS GO:0015695;GO:0015850;GO:0071705 molecular_function GO:0000293 ferric-chelate reductase activity is_a GO:7770068 WAS GO:0016722 molecular_function GO:0000514 3-sulfino-L-alanine is_a GO:0000099;GO:0005310;GO:0015078;GO:0015175;GO:0015179;GO:0072349;GO:0140848 WAS GO:0000099;GO:0015078;GO:0015175;GO:0015179;GO:0072349;GO:0140848 molecular_function GO:0002953 5'-deoxynucleotidase activity is_a GO:0008253 WAS GO:0016791 molecular_function GO:0003988 acetyl-CoA C-acyltransferase activity is_a GO:0016747 WAS GO:0016408 molecular_function GO:0004103 choline kinase activity relationship N/A WAS part_of GO:0006657 molecular_function GO:0004105 choline-phosphate cytidylyltransferase activity relationship N/A WAS part_of GO:0006657 molecular_function GO:0004129 cytochrome-c oxidase activity is_a GO:0009055;GO:0015078;GO:0015453;GO:0016675;GO:0022853 WAS GO:0009055;GO:0015078;GO:0015453;GO:0022853 relationship N/A WAS has_part GO:0016675 molecular_function GO:0004142 diacylglycerol cholinephosphotransferase activity relationship N/A WAS part_of GO:0006657 molecular_function GO:0004173 ecdysone O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0004321 fatty-acyl-CoA synthase activity is_a GO:0016747 WAS GO:0016408 molecular_function GO:0004366 glycerol-3-phosphate O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0004379 glycylpeptide N-tetradecanoyltransferase activity is_a GO:0019107 WAS GO:0016410;GO:0019107 molecular_function GO:0004498 calcidiol 1-monooxygenase activity is_a GO:0016713 WAS GO:0016709 molecular_function GO:0004506 squalene monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0004720 protein-lysine 6-oxidase activity is_a GO:0016641;GO:0140096 WAS GO:0052597;GO:0140096 molecular_function GO:0004772 sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0004970 glutamate-gated receptor activity is_a GO:0005310;GO:0008066;GO:0015171;GO:0022824 WAS GO:0008066;GO:0015171;GO:0022824;GO:0046943 molecular_function GO:0005048 signal sequence receptor activity is_a GO:0003674 WAS GO:0042277 molecular_function GO:0005308 creatine transmembrane transporter activity is_a GO:0008028;GO:0072349 WAS GO:0046943;GO:0072349 molecular_function GO:0005309 creatine:sodium symporter activity is_a GO:0005308;GO:0140161 WAS GO:0005308;GO:0005343 molecular_function GO:0005313 L-glutamate transmembrane transporter activity is_a GO:0005310;GO:0015172;GO:0015179 WAS GO:0015172;GO:0015179 molecular_function GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity is_a GO:0005283;GO:0005343;GO:0015185;GO:0015355;GO:0015378 WAS GO:0005283;GO:0015185;GO:0015378;GO:0140161 molecular_function GO:0005371 tricarboxylate secondary active transmembrane transporter activity is_a GO:0015142;GO:0015291 WAS GO:0015291;GO:0046943 molecular_function GO:0008080 N-acetyltransferase activity is_a GO:0016407 WAS GO:0016407;GO:0016410 molecular_function GO:0008121 quinol-cytochrome-c reductase activity is_a GO:0009055;GO:0015078;GO:0015453;GO:0016679;GO:0022853 WAS GO:0009055;GO:0015078;GO:0015453;GO:0022853 relationship N/A WAS has_part GO:0016679 molecular_function GO:0008137 NADH dehydrogenase (ubiquinone) activity is_a GO:0003954;GO:0009055;GO:0015078;GO:0015453;GO:0016655;GO:0022853 WAS GO:0009055;GO:0015078;GO:0015453;GO:0022853 relationship N/A WAS has_part GO:0003954;has_part GO:0016655 molecular_function GO:0008398 sterol 14-demethylase activity is_a GO:0016712;GO:0032451 WAS GO:0016709;GO:0032451 molecular_function GO:0008504 monoamine transmembrane transporter activity relationship N/A WAS part_of GO:0015844 molecular_function GO:0008508 bile acid:sodium symporter activity is_a GO:0005343;GO:0015125;GO:0015355 WAS GO:0015125;GO:0140161 molecular_function GO:0008517 folic acid transmembrane transporter activity is_a GO:0005310;GO:0072349;GO:0090482 WAS GO:0046943;GO:0072349;GO:0090482 molecular_function GO:0008762 UDP-N-acetylmuramate dehydrogenase activity is_a GO:0016628 WAS GO:0016616 molecular_function GO:0008779 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0008805 aerobic carbon monoxide dehydrogenase activity is_a GO:0052738 WAS GO:0016622 molecular_function GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase activity is_a GO:0016726 WAS GO:0016628 molecular_function GO:0008863 formate dehydrogenase (NAD+) activity is_a GO:0016726 WAS GO:0016620 molecular_function GO:0008873 gluconate 2-dehydrogenase (NADP+) activity is_a GO:0016616 WAS GO:0008875 molecular_function GO:0008874 gluconate 5-dehydrogenase [NAD(P)+] activity is_a GO:0016616 WAS GO:0008875 molecular_function GO:0010242 oxygen evolving activity is_a GO:0016682 WAS GO:0016491 molecular_function GO:0010277 chlorophyllide a oxygenase activity is_a GO:0016709 WAS GO:0016703 molecular_function GO:0010295 (+)-abscisic acid 8'-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0010314 phosphatidylinositol-5-phosphate binding is_a GO:0043168;GO:1901981 WAS GO:1901981 molecular_function GO:0015124 allantoate transmembrane transporter activity is_a GO:0008028 WAS GO:0046943 molecular_function GO:0015125 bile acid transmembrane transporter activity is_a GO:0046943;GO:0170055 WAS GO:0008028;GO:0170055 molecular_function GO:0015128 gluconate transmembrane transporter activity is_a GO:0015144;GO:0042879 WAS GO:0042879 molecular_function GO:0015130 mevalonate transmembrane transporter activity is_a GO:0008028 WAS GO:0022857 molecular_function GO:0015131 oxaloacetate transmembrane transporter activity is_a GO:0015556 WAS GO:0005310;GO:0015556 molecular_function GO:0015133 uronic acid transmembrane transporter activity is_a GO:0008028 WAS GO:0046943 molecular_function GO:0015134 hexuronate transmembrane transporter activity is_a GO:0015145;GO:0046943 WAS GO:0008028;GO:0015145 molecular_function GO:0015138 fumarate transmembrane transporter activity is_a GO:0015556 WAS GO:0005310;GO:0015556 molecular_function GO:0015140 malate transmembrane transporter activity is_a GO:0015556 WAS GO:0005310;GO:0015556 molecular_function GO:0015141 succinate transmembrane transporter activity is_a GO:0015556 WAS GO:0005310;GO:0015556 molecular_function GO:0015183 L-aspartate transmembrane transporter activity is_a GO:0015172;GO:0015179;GO:0015556 WAS GO:0005310;GO:0015172;GO:0015179;GO:0015556 molecular_function GO:0015185 gamma-aminobutyric acid transmembrane transporter activity is_a GO:0015171;GO:0046943 WAS GO:0008028;GO:0015171 molecular_function GO:0015231 5-formyltetrahydrofolate transmembrane transporter activity is_a GO:0005310;GO:0072349 WAS GO:0046943;GO:0072349 molecular_function GO:0015233 pantothenate transmembrane transporter activity is_a GO:0008028;GO:0072349;GO:0090482 WAS GO:0046943;GO:0072349;GO:0090482 molecular_function GO:0015317 phosphate:proton symporter activity is_a GO:0005315;GO:0015295 WAS GO:0015295 molecular_function GO:0015355 secondary active monocarboxylate transmembrane transporter activity is_a GO:0015291;GO:0046943 WAS GO:0008028;GO:0015291 molecular_function GO:0015432 ABC-type bile acid transporter activity is_a GO:0015125;GO:0033284;GO:0034040;GO:0140359 WAS GO:0015125;GO:0033285;GO:0034040;GO:0140359 molecular_function GO:0015436 ABC-type capsular-polysaccharide transporter activity is_a GO:0033285;GO:0140359 WAS GO:0033284;GO:0140359 molecular_function GO:0015498 pantothenate:sodium symporter activity is_a GO:0072349;GO:0140161 WAS GO:0005343;GO:0046943;GO:0072349 molecular_function GO:0015501 glutamate:sodium symporter activity is_a GO:0005283;GO:0017153 WAS GO:0005283;GO:0005343;GO:0046943 molecular_function GO:0015554 tartrate transmembrane transporter activity is_a GO:0015144;GO:0015556;GO:0042876 WAS GO:0005310;GO:0015144;GO:0015556;GO:0042876 molecular_function GO:0015556 C4-dicarboxylate transmembrane transporter activity is_a GO:0005310 WAS GO:0046943 molecular_function GO:0015568 L-idonate transmembrane transporter activity is_a GO:0015144;GO:0042879 WAS GO:0008028;GO:0015144;GO:0042879 molecular_function GO:0015649 2-keto-3-deoxygluconate:proton symporter activity is_a GO:0005351;GO:0008028;GO:0015145;GO:0015355 WAS GO:0005351;GO:0015145;GO:0015355 molecular_function GO:0016406 carnitine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0016411 acylglycerol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0016412 serine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0016413 O-acetyltransferase activity is_a GO:0016407 WAS GO:0008374;GO:0016407 molecular_function GO:0016414 diglucosylglycerate octanoyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0016416 O-palmitoyltransferase activity is_a GO:0016409 WAS GO:0008374;GO:0016409 molecular_function GO:0016418 S-acetyltransferase activity is_a GO:0016407 WAS GO:0016407;GO:0016417 molecular_function GO:0016419 S-malonyltransferase activity is_a GO:0016420 WAS GO:0016417;GO:0016420 molecular_function GO:0016453 C-acetyltransferase activity is_a GO:0016407 WAS GO:0016407;GO:0016408 molecular_function GO:0016454 C-palmitoyltransferase activity is_a GO:0016409 WAS GO:0016408;GO:0016409 molecular_function GO:0016710 trans-cinnamate 4-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0016711 flavonoid 3'-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0016749 N-succinyltransferase activity is_a GO:0016748 WAS GO:0016410;GO:0016748 molecular_function GO:0016750 O-succinyltransferase activity is_a GO:0016748 WAS GO:0008374;GO:0016748 molecular_function GO:0016751 S-succinyltransferase activity is_a GO:0016748 WAS GO:0016417;GO:0016748 molecular_function GO:0016753 O-sinapoyltransferase activity is_a GO:0016752 WAS GO:0008374;GO:0016752 molecular_function GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity is_a GO:0016747;GO:0140096 WAS GO:0016410;GO:0140096 molecular_function GO:0018525 4-hydroxybenzoyl-CoA reductase activity is_a GO:0016614 WAS GO:0016636 molecular_function GO:0018554 1,2-dihydroxynaphthalene dioxygenase activity is_a GO:0016702 WAS GO:0016701;GO:0051213 molecular_function GO:0018570 p-cumate 2,3-dioxygenase activity is_a GO:0016708 WAS GO:0016702 molecular_function GO:0018664 benzoate 4-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0019707 protein-cysteine S-acyltransferase activity is_a GO:0016747;GO:0140096 WAS GO:0016417;GO:0140096 molecular_function GO:0030270 formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0032441 pheophorbide a oxygenase activity is_a GO:0016713 WAS GO:0016730 molecular_function GO:0032576 O-linoleoyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0033229 L-cysteine transmembrane transporter activity is_a GO:0000099;GO:0015175;GO:0015179 WAS GO:0000099;GO:0015175 molecular_function GO:0033717 gluconate 2-dehydrogenase (acceptor) activity is_a GO:0016614 WAS GO:0008875 molecular_function GO:0033759 flavone synthase activity is_a GO:0050498 WAS GO:0016706 molecular_function GO:0033772 flavonoid 3',5'-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0033775 deoxysarpagine hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0033777 lithocholate 6beta-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0033781 cholesterol 24-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0033813 deacetylcephalosporin-C acetyltransferase activity is_a GO:0016747 WAS GO:0016408 molecular_function GO:0033814 propanoyl-CoA C-acyltransferase activity is_a GO:0016747 WAS GO:0016408 molecular_function GO:0034318 alcohol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0034353 mRNA 5'-diphosphatase activity is_a GO:0004651;GO:0016462;GO:0140098 WAS GO:0016462;GO:0140098 molecular_function GO:0034590 L-hydroxyproline transmembrane transporter activity is_a GO:0015179;GO:0072349 WAS GO:0008028;GO:0015179;GO:0072349 molecular_function GO:0035599 aspartic acid methylthiotransferase activity relationship N/A WAS part_of GO:0018339 molecular_function GO:0036189 abieta-7,13-diene hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0036199 cholest-4-en-3-one 26-monooxygenase activity is_a GO:0016713 WAS GO:0016709 molecular_function GO:0036201 ent-isokaurene C2-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0036202 ent-cassa-12,15-diene 11-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0036204 abieta-7,13-dien-18-ol hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0036209 9beta-pimara-7,15-diene oxidase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0042878 D-glucarate transmembrane transporter activity is_a GO:0015144;GO:0042876 WAS GO:0005310;GO:0015144;GO:0042876 molecular_function GO:0042879 aldonate transmembrane transporter activity is_a GO:0008028 WAS GO:0046943 molecular_function GO:0042925 benzoate transmembrane transporter activity is_a GO:0008028;GO:0042910 WAS GO:0042910;GO:0046943 molecular_function GO:0042933 chrysobactin transmembrane transporter activity is_a GO:0015343;GO:0015665;GO:0046943;GO:0071916 WAS GO:0008028;GO:0015343;GO:0015665;GO:0071916 molecular_function GO:0043808 lyso-ornithine lipid acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0043810 ornithine-acyl [acyl carrier protein] N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0044104 2,5-dioxovalerate dehydrogenase (NAD+) activity is_a GO:0004029 WAS GO:0016620 molecular_function GO:0044183 protein folding chaperone relationship part_of GO:0006457 WAS has_part GO:0051082;part_of GO:0006457 molecular_function GO:0044684 dihydromethanopterin reductase activity is_a GO:0016645 WAS GO:0016646 molecular_function GO:0044875 gamma-glutamyl hercynylcysteine sulfoxide synthase activity relationship part_of GO:0052699 WAS part_of GO:0052704 molecular_function GO:0045431 flavonol synthase activity is_a GO:0050498 WAS GO:0016706 molecular_function GO:0047081 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity is_a GO:0016709 WAS GO:0016708 molecular_function GO:0047082 3,9-dihydroxypterocarpan 6a-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047083 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047084 methyltetrahydroprotoberberine 14-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047087 protopine 6-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047088 dihydrosanguinarine 10-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047089 dihydrochelirubine 12-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0047091 L-lysine 6-monooxygenase (NADPH) activity is_a GO:0016709 WAS GO:0016703;GO:0016709 molecular_function GO:0047111 formate dehydrogenase (cytochrome-c-553) activity is_a GO:0016725 WAS GO:0016622 molecular_function GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity is_a GO:0042171 WAS GO:0008374;GO:0042171 molecular_function GO:0047159 plasmalogen synthase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047166 1-alkenylglycerophosphoethanolamine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047167 1-alkyl-2-acetylglycerol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047174 putrescine N-hydroxycinnamoyltransferase activity is_a GO:0050734 WAS GO:0016410;GO:0050734 molecular_function GO:0047175 galactosylacylglycerol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047190 2-acylglycerophosphocholine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047194 indoleacetylglucose-inositol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047195 diacylglycerol-sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047197 triglyceride-sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047199 phosphatidylcholine-dolichol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047594 6-beta-hydroxyhyoscyamine epoxidase activity is_a GO:0050498 WAS GO:0016706 molecular_function GO:0047872 dolichol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047899 formate dehydrogenase (NADP+) activity is_a GO:0016726 WAS GO:0016620 molecular_function GO:0047909 galactolipid O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0047957 4'-methoxyisoflavone 2'-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0048000 isoflavone 3'-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050252 retinol O-fatty-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0050291 sphingosine N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0050588 apo-beta-carotenoid-14',13'-dioxygenase activity is_a GO:0016702 WAS GO:0016703 molecular_function GO:0050589 leucocyanidin oxygenase activity is_a GO:0050498 WAS GO:0016706 molecular_function GO:0050591 quinine 3-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050592 4-hydroxyphenylacetaldehyde oxime monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050593 N-methylcoclaurine 3'-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050594 tabersonine 16-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050596 vinorine hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050597 taxane 10-beta-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050598 taxane 13-alpha-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0050607 S-(hydroxymethyl)mycothiol dehydrogenase activity is_a GO:0016616 WAS GO:0016620 molecular_function GO:0050616 secologanin synthase activity is_a GO:0016717 WAS GO:0016634 molecular_function GO:0050633 acetyl-CoA C-myristoyltransferase activity is_a GO:0019107 WAS GO:0016408;GO:0019107 molecular_function GO:0050640 isopenicillin-N N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0050735 N-malonyltransferase activity is_a GO:0016420 WAS GO:0016410;GO:0016420 molecular_function GO:0050736 O-malonyltransferase activity is_a GO:0016420 WAS GO:0008374;GO:0016420 molecular_function GO:0050737 O-hydroxycinnamoyltransferase activity is_a GO:0050734 WAS GO:0008374;GO:0050734 molecular_function GO:0052851 ferric-chelate reductase (NADPH) activity is_a GO:0000293 WAS GO:0000293;GO:0016723 molecular_function GO:0061579 N-acyl homoserine lactone synthase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0061686 hercynylcysteine sulfoxide synthase activity relationship part_of GO:0052699 WAS part_of GO:0140479 molecular_function GO:0061920 protein propionyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0070007 glutamic-type endopeptidase activity is_a GO:0004175;GO:0070002 WAS N/A molecular_function GO:0070906 aspartate:alanine antiporter activity is_a GO:0015297;GO:0015556;GO:0022858 WAS GO:0005310;GO:0015297;GO:0015556;GO:0022858 molecular_function GO:0070909 glutamate:gamma-aminobutyric acid antiporter activity is_a GO:0005310;GO:0015185;GO:0015297;GO:0015355 WAS GO:0015185;GO:0015297;GO:0015355 molecular_function GO:0080072 spermidine:sinapoyl CoA N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0080073 spermidine:coumaroyl CoA N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0080074 spermidine:caffeoyl CoA N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0080075 spermidine:feruloyl CoA N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0080089 sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0080095 phosphatidylethanolamine-sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0080096 phosphatidate-sterol O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0090447 glycerol-3-phosphate 2-O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0102001 isoleucine N-monooxygenase (oxime forming) activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102002 valine N-monooxygenase (oxime forming) activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102068 alpha-humulene 10-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102170 5-epi-aristolochene-1,3-dihydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102177 4alpha-monomethylsterol monooxygenase activity is_a GO:0016716 WAS GO:0016709 molecular_function GO:0102289 beta-amyrin 11-oxidase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102320 1,8-cineole 2-exo-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102375 11-oxo-beta-amyrin 30-oxidase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102394 L-isoleucine 4-hydroxylase activity is_a GO:0016706 WAS GO:0016616 molecular_function GO:0102556 dammarenediol 12-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102557 protopanaxadiol 6-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102596 cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102597 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102598 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102684 L-phenylalanine N-monooxygenase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102717 DIBOA-glucoside oxygenase activity is_a GO:0016706 WAS GO:0050498 molecular_function GO:0102811 geraniol 10-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102876 psoralen synthase (NADPH) activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102915 piperitol synthase activity is_a GO:0016717 WAS GO:0016709 molecular_function GO:0102934 costunolide synthase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0102995 angelicin synthase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0106075 peptide N-succinyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0106144 fraxetin 5-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0106145 scopoletin 8-hydroxylase activity is_a GO:0016706 WAS GO:0016709 molecular_function GO:0106149 indole-3-carbonyl nitrile 4-hydroxylase activity is_a GO:0016712 WAS GO:0016709 molecular_function GO:0106226 peptide 2-hydroxyisobutyryltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0106228 peptide glutaryltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity is_a GO:0016747 WAS GO:0008374 molecular_function GO:0120294 peptide serotonyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0120296 peptide dopaminyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0120298 peptide noradrenalinyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0120299 peptide histaminyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0120300 peptide lactyltransferase (CoA-dependent) activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0120571 dihydrolipoyllysine-residue glutaryltransferase activity is_a GO:0016747 WAS GO:0016417 molecular_function GO:0140010 D-aspartate transmembrane transporter activity is_a GO:0015556;GO:0042943 WAS GO:0005310;GO:0015556;GO:0042943 molecular_function GO:0140064 peptide crotonyltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0140065 peptide butyryltransferase activity is_a GO:0016747 WAS GO:0016410 molecular_function GO:0140161 monocarboxylate:sodium symporter activity is_a GO:0005343;GO:0008028 WAS GO:0005343;GO:0015355 molecular_function GO:0140186 protein N-acyltransferase activity is_a GO:0016747;GO:0140096 WAS GO:0016410;GO:0140096 molecular_function GO:0140443 mitochondrion-plasma membrane adaptor activity is_a GO:0140177 WAS GO:0043495 molecular_function GO:0140618 ferric-chelate reductase (NADH) activity is_a GO:0000293 WAS GO:0000293;GO:0016723 molecular_function GO:0140812 orotate:monoatomic anion antiporter activity is_a GO:0008028;GO:0008509;GO:0015297;GO:0015355 WAS GO:0008509;GO:0015297;GO:0015355 molecular_function GO:0140818 mRNA 5'-triphosphate monophosphatase activity is_a GO:0004651;GO:0016462;GO:0140098 WAS GO:0016462;GO:0140098 molecular_function GO:0160183 autophagosome-membrane adaptor activity is_a GO:0140177;GO:0160247 WAS GO:0043495;GO:0160247 molecular_function GO:0160190 peroxisome-mitochondrion membrane tether activity is_a GO:0140177 WAS GO:0043495 molecular_function GO:0160204 mitochondrion-mitochondrion outer membrane tether activity is_a GO:0140177 WAS GO:0043495 molecular_function GO:0160214 endoplasmic reticulum-plasma membrane adaptor activity is_a GO:0140177 WAS GO:0043495 molecular_function GO:0170008 mRNA phosphatase activator activity is_a GO:0019211 WAS GO:0008047 molecular_function GO:0170009 endoplasmic reticulum-organelle membrane tether activity is_a GO:0140177 WAS GO:0043495 molecular_function GO:1901974 glycerate transmembrane transporter activity is_a GO:0015144;GO:0042879 WAS GO:0008028;GO:0015144;GO:0042879 cellular_component GO:0002102 podosome is_a GO:0098858 WAS GO:0043232 relationship N/A WAS part_of GO:0015629 cellular_component GO:0032420 stereocilium relationship part_of GO:0032421 WAS part_of GO:0032421;part_of GO:0043226 cellular_component GO:0045275 respiratory chain complex III is_a GO:0070069;GO:0098803;GO:1902495;GO:1990204 WAS GO:0070069;GO:0098803;GO:1902495 cellular_component GO:0045277 respiratory chain complex IV is_a GO:0070069;GO:0098803;GO:1902495;GO:1990204 WAS GO:0070069;GO:0098803;GO:1902495 cellular_component GO:0060171 stereocilium membrane relationship part_of GO:0032420 WAS part_of GO:0005622;part_of GO:0032420 cellular_component GO:0061852 retrograde cargo receptor complex, Golgi to ER is_a GO:0062137 WAS GO:1990351 cellular_component GO:0070867 mating projection tip membrane relationship part_of GO:0043332;part_of GO:0070250 WAS part_of GO:0043332 cellular_component GO:0098858 actin-based cell projection relationship part_of GO:0015629 WAS has_part GO:0005884 cellular_component GO:0110103 RNA polymerase II termination complex is_a GO:0140513;GO:1903293;GO:1905354 WAS GO:0140513;GO:1905354