# GORULE violations assigned by HGNC-UCL

## SUMMARY

This report generated on 2026-05-21

## Contents

[gorule-0000008](#gorule-0000008)[No annotations should be made to uninformative high level terms]{}

[gorule-0000016](#gorule-0000016)[With/From: IC annotations require a With/From GO ID]{}

[gorule-0000020](#gorule-0000020)[Automatic repair of annotations to merged or obsoleted terms]{}

[gorule-0000046](#gorule-0000046)[The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.]{}

[gorule-0000061](#gorule-0000061)[Allowed gene product to term relations (gp2term)]{}

## MESSAGES

###gorule-0000008

No annotations should be made to uninformative high level terms

* total: 2
#### Messages
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:2384968	L2hgdh	involved_in	GO:0044281	GO_REF:0000024	ISS	UniProtKB:Q9H9P8	P	L-2-hydroxyglutarate dehydrogenase		protein	NCBITaxon:10090	20210921	HGNC-UCL		MGI:MGI:2384968
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	Q9H9P8	L2HGDH	involved_in	GO:0044281	PMID:16005139	IDA		P	L-2-hydroxyglutarate dehydrogenase, mitochondrial	L2HGDH|C14orf160	protein	taxon:9606	20210921	HGNC-UCL		UniProtKB:Q9H9P8
`

###gorule-0000016

With/From: IC annotations require a With/From GO ID

* total: 1
#### Messages
* WARNING - Violates GO Rule:GORULE:0000016: All IC annotations should include a GO ID in the "With/From" column that is also different from the entry in the "GO ID" column--`UniProtKB	P60662	MYL6	enables	GO:0000146	PMID:16953301	IC	GO:0000146	F	Myosin light polypeptide 6	MYL6	protein	taxon:9823	20070416	HGNC-UCL		UniProtKB:P60662
`

###gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 17
#### Messages
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1927550	Ykt6	involved_in	GO:0006904	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 v-SNARE homolog (S. cerevisiae)	0610042I15Rik|1810013M05Rik	protein	NCBITaxon:10090	20070906	HGNC-UCL		MGI:MGI:1927550
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`RGD	70897	Ykt6	involved_in	GO:0006904	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 vesicular SNARE protein		protein	NCBITaxon:10116	20070906	HGNC-UCL		RGD:70897
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	O15498	YKT6	involved_in	GO:0006904	PMID:9211930	IDA		P	Synaptobrevin homolog YKT6	YKT6	protein	taxon:9606	20060707	HGNC-UCL		UniProtKB:O15498
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`WB	WBGene00015164	ykt-6	involved_in	GO:0006904	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 (Yeast v-SNARE) homolog	B0361.10|CELE_B0361.10|ykt-6	protein	NCBITaxon:6239	20060707	HGNC-UCL		WB:WBGene00015164
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	Q3T000	YKT6	involved_in	GO:0006904	GO_REF:0000024	ISS	UniProtKB:O15498	P	Synaptobrevin homolog YKT6	YKT6	protein	taxon:9913	20060707	HGNC-UCL		UniProtKB:Q3T000
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`Xenbase	XB-GENE-6254082	ykt6.L	acts_upstream_of_or_within	GO:0006904	GO_REF:0000024	ISS	UniProtKB:O15498	P	YKT6 v-SNARE homolog L homeolog	snare1|xsnare1|ykt6-a|ykt6-b	protein	taxon:8355	20060707	HGNC-UCL		
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI	MGI:1927550	Ykt6	involved_in	GO:0006903	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 v-SNARE homolog (S. cerevisiae)	0610042I15Rik|1810013M05Rik	protein	NCBITaxon:10090	20070906	HGNC-UCL		MGI:MGI:1927550
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`RGD	620970	Tmed10	involved_in	GO:0006903	PMID:8663407	NAS		P	transmembrane p24 trafficking protein 10		protein	NCBITaxon:10116	20050905	HGNC-UCL		RGD:620970
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`RGD	69243	Tmed2	involved_in	GO:0006903	PMID:8663407	NAS		P	transmembrane p24 trafficking protein 2		protein	NCBITaxon:10116	20050905	HGNC-UCL		RGD:69243
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`RGD	70897	Ykt6	involved_in	GO:0006903	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 vesicular SNARE protein		protein	NCBITaxon:10116	20070906	HGNC-UCL		RGD:70897
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`UniProtKB	O15498	YKT6	involved_in	GO:0006903	PMID:9211930	IDA		P	Synaptobrevin homolog YKT6	YKT6	protein	taxon:9606	20060707	HGNC-UCL		UniProtKB:O15498
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`WB	WBGene00015164	ykt-6	involved_in	GO:0006903	PMID:9211930	ISS	UniProtKB:O15498	P	YKT6 (Yeast v-SNARE) homolog	B0361.10|CELE_B0361.10|ykt-6	protein	NCBITaxon:6239	20060707	HGNC-UCL		WB:WBGene00015164
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`UniProtKB	Q3T000	YKT6	involved_in	GO:0006903	GO_REF:0000024	ISS	UniProtKB:O15498	P	Synaptobrevin homolog YKT6	YKT6	protein	taxon:9913	20060707	HGNC-UCL		UniProtKB:Q3T000
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`Xenbase	XB-GENE-6254082	ykt6.L	acts_upstream_of_or_within	GO:0006903	GO_REF:0000024	ISS	UniProtKB:O15498	P	YKT6 v-SNARE homolog L homeolog	snare1|xsnare1|ykt6-a|ykt6-b	protein	taxon:8355	20060707	HGNC-UCL		
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`MGI	MGI:1915831	Tmed10	involved_in	GO:0048199	PMID:17101722	IEP		P	transmembrane p24 trafficking protein 10	1110014C03Rik|p23|p24delta1	protein	NCBITaxon:10090	20070412	HGNC-UCL		MGI:MGI:1915831
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`RGD	620970	Tmed10	involved_in	GO:0048199	PMID:17101722	IEP		P	transmembrane p24 trafficking protein 10		protein	NCBITaxon:10116	20070412	HGNC-UCL		RGD:620970
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`UniProtKB	P49755	TMED10	involved_in	GO:0048199	GO_REF:0000024	ISS	UniProtKB:Q9D1D4	P	Transmembrane emp24 domain-containing protein 10	TMED10|TMP21	protein	taxon:9606	20070412	HGNC-UCL		UniProtKB:P49755
`

###gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 16
#### Messages
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1891731	Stub1	enables	GO:0042803	PMID:16307917	IPI	UniProtKB:Q9WUD1	F	STIP1 homology and U-Box containing protein 1	0610033N24Rik|2210017D18Rik|2310040B03Rik|CHIP	protein	NCBITaxon:10090	20230221	HGNC-UCL		MGI:MGI:1891731
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1926483	Nectin1	enables	GO:0042803	PMID:12826663	IPI	UniProtKB:Q9JKF6	F	nectin cell adhesion molecule 1	Cd111|HIgR|HveC|PRR|PRR1|Pvrl1|nectin-1	protein	NCBITaxon:10090	20230221	HGNC-UCL		MGI:MGI:1926483
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1930171	Nectin3	enables	GO:0042803	PMID:12826663	IPI	UniProtKB:Q9JLB9	F	nectin cell adhesion molecule 3	2610301B19Rik|3000002N23Rik|4921513D19Rik|Pvrl3|nectin-3	protein	NCBITaxon:10090	20230221	HGNC-UCL		MGI:MGI:1930171
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:2137858	Cadm3	enables	GO:0042803	PMID:12826663	IPI	UniProtKB:Q99N28	F	cell adhesion molecule 3	BIgR|Igsf4b|Necl-1|Necl1|SynCAM3|Tsll1	protein	NCBITaxon:10090	20230221	HGNC-UCL		MGI:MGI:2137858
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:97822	Nectin2	enables	GO:0042803	PMID:12826663	IPI	UniProtKB:P32507	F	nectin cell adhesion molecule 2	Cd112|MPH|Pvrl2|Pvs|nectin-2	protein	NCBITaxon:10090	20230221	HGNC-UCL		MGI:MGI:97822
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P13945	ADRB3	enables	GO:0042803	PMID:15123695	IDA		F	Beta-3 adrenergic receptor	ADRB3|ADRB3R|B3AR	protein	taxon:9606	20060628	HGNC-UCL		UniProtKB:P13945
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P20585	MSH3	NOT|enables	GO:0042803	PMID:8942985	IDA		F	DNA mismatch repair protein Msh3	MSH3|DUC1|DUG	protein	taxon:9606	20060905	HGNC-UCL		UniProtKB:P20585
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P21549	AGXT	enables	GO:0042803	PMID:12899834	IDA		F	Alanine--glyoxylate aminotransferase	AGXT|AGT1|SPAT	protein	taxon:9606	20060810	HGNC-UCL		UniProtKB:P21549
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P43246	MSH2	enables	GO:0042803	PMID:8942985	IDA		F	DNA mismatch repair protein Msh2	MSH2	protein	taxon:9606	20060905	HGNC-UCL		UniProtKB:P43246
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q07812	BAX	enables	GO:0042803	PMID:16608847	IDA		F	Apoptosis regulator BAX	BAX|BCL2L4	protein	taxon:9606	20070301	HGNC-UCL		UniProtKB:Q07812
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q12904	AIMP1	enables	GO:0042803	PMID:11306575	IDA		F	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	AIMP1|EMAP2|SCYE1	protein	taxon:9606	20071018	HGNC-UCL		UniProtKB:Q12904
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q15257	PTPA	enables	GO:0042803	PMID:16916641	IDA		F	Serine/threonine-protein phosphatase 2A activator	PTPA|PPP2R4	protein	taxon:9606	20070426	HGNC-UCL		UniProtKB:Q15257
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q9NPP4	NLRC4	enables	GO:0042803	PMID:15107016	IDA		F	NLR family CARD domain-containing protein 4	NLRC4|CARD12|CLAN|CLAN1|IPAF|UNQ6189/PRO20215	protein	taxon:9606	20060524	HGNC-UCL		UniProtKB:Q9NPP4
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q9ULZ3	PYCARD	enables	GO:0042803	PMID:15030775	IDA		F	Apoptosis-associated speck-like protein containing a CARD	PYCARD|ASC|CARD5|TMS1	protein	taxon:9606	20060525	HGNC-UCL		UniProtKB:Q9ULZ3
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q9Y2G2	CARD8	enables	GO:0042803	PMID:15030775	IDA		F	Caspase recruitment domain-containing protein 8	CARD8|DACAR|KIAA0955|NDPP1	protein	taxon:9606	20060525	HGNC-UCL		UniProtKB:Q9Y2G2
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	Q9Y697	NFS1	enables	GO:0042803	PMID:16527810	IDA		F	Cysteine desulfurase	NFS1|NIFS|HUSSY-08	protein	taxon:9606	20071022	HGNC-UCL		UniProtKB:Q9Y697
`

###gorule-0000061

Allowed gene product to term relations (gp2term)

* total: 2
#### Messages
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`UniProtKB	P12883	MYH7	is_active_in	GO:0016459	PMID:12933792	TAS		C	Myosin-7	MYH7|MYHCB	protein	taxon:9606	20240214	HGNC-UCL		UniProtKB:P12883
`
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: RO:0002432 should be one of BFO:0000050. Repaired to BFO:0000050--`UniProtKB	P13533	MYH6	is_active_in	GO:0016459	PMID:12933792	TAS		C	Myosin-6	MYH6|MYHCA	protein	taxon:9606	20240214	HGNC-UCL		UniProtKB:P13533
`