# GORULE violations assigned by ParkinsonsUK-UCL

## SUMMARY

This report generated on 2026-05-21

## Contents

[gorule-0000005](#gorule-0000005)[IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations are not allowed for direct annotations to 'protein binding ; GO:0005515 or GO:0005488 binding'']{}

[gorule-0000013](#gorule-0000013)[Taxon-appropriate annotation check]{}

[gorule-0000020](#gorule-0000020)[Automatic repair of annotations to merged or obsoleted terms]{}

[gorule-0000039](#gorule-0000039)[Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants]{}

[gorule-0000046](#gorule-0000046)[The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.]{}

[gorule-0000061](#gorule-0000061)[Allowed gene product to term relations (gp2term)]{}

## MESSAGES

###gorule-0000005

IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations are not allowed for direct annotations to 'protein binding ; GO:0005515 or GO:0005488 binding''

* total: 1
#### Messages
* WARNING - Violates GO Rule:GORULE:0000005: IEA, ISS, ISO, ISM, ISA, IBA, RCA annotations ae not allowed for direct annotations to 'binding ; GO:0005488' or 'protein binding ; GO:0005515'--`RGD	621808	Park7	enables	GO:0005515	GO_REF:0000024	ISS	UniProtKB:Q99497	F	Parkinsonism associated deglycase		protein	NCBITaxon:10116	20210910	ParkinsonsUK-UCL		RGD:621808
`

###gorule-0000013

Taxon-appropriate annotation check

* total: 3
#### Messages
* ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB	P63027	VAMP2	enables	GO:0017075	GO_REF:0000024	ISS	UniProtKB:P63045	F	Vesicle-associated membrane protein 2	VAMP2|SYB2	protein	taxon:9606	20140922	ParkinsonsUK-UCL		UniProtKB:P63027
`
* ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB	P63027	VAMP2	enables	GO:0019905	GO_REF:0000024	ISS	UniProtKB:P63044	F	Vesicle-associated membrane protein 2	VAMP2|SYB2	protein	taxon:9606	20140922	ParkinsonsUK-UCL		UniProtKB:P63027
`
* ERROR - Violates GO Rule:GORULE:0000013: Taxon-appropriate annotation check--`UniProtKB	Q9UPW8	UNC13A	enables	GO:0017075	GO_REF:0000024	ISS	UniProtKB:Q62768	F	Protein unc-13 homolog A	UNC13A|KIAA1032	protein	taxon:9606	20140731	ParkinsonsUK-UCL		UniProtKB:Q9UPW8
`

###gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 12
#### Messages
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:107363	Stxbp1	involved_in	GO:0006904	PMID:18703708	IMP		P	syntaxin binding protein 1	Munc-18a|Munc18-1|N-sec1|Rb-sec1|Sxtbp1|Unc18h|nsec1	protein	NCBITaxon:10090	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	MGI:MGI:107363
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1930705	Stx1b	involved_in	GO:0006904	PMID:18703708	IMP		P	syntaxin 1B	Stx1b2	protein	NCBITaxon:10090	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	MGI:MGI:1930705
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`RGD	3784	Stx1b	involved_in	GO:0006904	GO_REF:0000024	ISS	UniProtKB:P61264	P	syntaxin 1B		protein	NCBITaxon:10116	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	RGD:3784
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`RGD	3785	Stxbp1	involved_in	GO:0006904	GO_REF:0000024	ISS	UniProtKB:O08599	P	syntaxin binding protein 1		protein	NCBITaxon:10116	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	RGD:3785
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	P61266	STX1B	involved_in	GO:0006904	GO_REF:0000024	ISS	UniProtKB:P61264	P	Syntaxin-1B	STX1B|STX1B1|STX1B2	protein	taxon:9606	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	UniProtKB:P61266
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	P61764	STXBP1	involved_in	GO:0006904	GO_REF:0000024	ISS	UniProtKB:O08599	P	Syntaxin-binding protein 1	STXBP1|UNC18A	protein	taxon:9606	20160719	ParkinsonsUK-UCL	occurs_in(CL:0000166)	UniProtKB:P61764
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1930705	Stx1b	involved_in	GO:0016081	PMID:24133272	IGI	UniProtKB:O35526	P	syntaxin 1B	Stx1b2	protein	NCBITaxon:10090	20140828	ParkinsonsUK-UCL	occurs_in(CL:0002608)	MGI:MGI:1930705
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1930705	Stx1b	involved_in	GO:0016081	PMID:24587181	IMP		P	syntaxin 1B	Stx1b2	protein	NCBITaxon:10090	20160727	ParkinsonsUK-UCL	occurs_in(UBERON:0014554)	MGI:MGI:1930705
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`RGD	3784	Stx1b	involved_in	GO:0016081	GO_REF:0000024	ISS	UniProtKB:P61264	P	syntaxin 1B		protein	NCBITaxon:10116	20140908	ParkinsonsUK-UCL	occurs_in(CL:0002608)	RGD:3784
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	P61266	STX1B	involved_in	GO:0016081	GO_REF:0000024	ISS	UniProtKB:P61264	P	Syntaxin-1B	STX1B|STX1B1|STX1B2	protein	taxon:9606	20140908	ParkinsonsUK-UCL	occurs_in(CL:0002608)	UniProtKB:P61266
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	P46379	BAG6	enables	GO:0140597	PMID:21636303	IDA		F	Large proline-rich protein BAG6	BAG6|BAT3|G3	protein	taxon:9606	20241101	ParkinsonsUK-UCL	part_of(GO:0036506)	UniProtKB:P46379
`
* WARNING - Obsolete class:Violates GORULE:0000020, but was repaired--`SGD	S000000113	PEP1	involved_in	GO:0048203	PMID:25533483	TAS		P	type I sorting receptor	VPS10|VPT1|YBL017C	protein	NCBITaxon:559292	20170712	ParkinsonsUK-UCL		SGD:S000000113
`

###gorule-0000039

Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants

* total: 1
#### Messages
* ERROR - Violates GO Rule:GORULE:0000039: Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants--`ComplexPortal	CPX-263	nsfl1c-vcp_rat	part_of	GO:1990730	PMID:9214505	IDA		C	Vcp-Nsfl1c AAA ATPase complex	3xNsfl1c:6xVcp|p47-VCP complex|NSFL1-VCP complex|NSFL1-p97 complex|p47-p97 complex|NSFL1C-p97 complex	protein_complex	taxon:10116	20180219	ParkinsonsUK-UCL		
`

###gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 8
#### Messages
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1352504	Hip1r	enables	GO:0042803	PMID:11564758	IPI	UniProtKB:Q9JKY5	F	huntingtin interacting protein 1 related		protein	NCBITaxon:10090	20230309	ParkinsonsUK-UCL		MGI:MGI:1352504
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1352504	Hip1r	enables	GO:0042803	PMID:15533940	IPI	UniProtKB:Q9JKY5	F	huntingtin interacting protein 1 related		protein	NCBITaxon:10090	20230309	ParkinsonsUK-UCL		MGI:MGI:1352504
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1352504	Hip1r	enables	GO:0042803	PMID:18790740	IPI	UniProtKB:Q9JKY5	F	huntingtin interacting protein 1 related		protein	NCBITaxon:10090	20230309	ParkinsonsUK-UCL		MGI:MGI:1352504
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1921256	Dnm1l	enables	GO:0042803	PMID:20585624	IPI	UniProtKB:Q8K1M6	F	dynamin 1-like	6330417M19Rik|Dnmlp1|Drp1|python	protein	NCBITaxon:10090	20230309	ParkinsonsUK-UCL		MGI:MGI:1921256
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`RGD	2326	Cebpa	enables	GO:0042803	PMID:8657121	IPI	UniProtKB:P05554	F	CCAAT/enhancer binding protein alpha		protein	NCBITaxon:10116	20141016	ParkinsonsUK-UCL		RGD:2326
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`RGD	619781	Erp29	enables	GO:0042803	PMID:9714535	IPI	UniProtKB:P52555	F	endoplasmic reticulum protein 29		protein	NCBITaxon:10116	20230309	ParkinsonsUK-UCL		RGD:619781
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`RGD	68397	Syt4	enables	GO:0042803	PMID:10397765	IPI	UniProtKB:P50232	F	synaptotagmin 4		protein	NCBITaxon:10116	20230309	ParkinsonsUK-UCL		RGD:68397
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`SGD	S000003924	DNM1	involved_in	GO:0051260	PMID:21170049	IDA		P	dynamin-related GTPase DNM1	DRP1|YLL001W	protein	NCBITaxon:559292	20170207	ParkinsonsUK-UCL		SGD:S000003924
`

###gorule-0000061

Allowed gene product to term relations (gp2term)

* total: 1
#### Messages
* WARNING - Violates GO Rule:GORULE:0000061: Found violation of: `Only certain gene product to term relations are allowed for a given GO term` but was repaired: BFO:0000050 should be one of RO:0001025, RO:0002325, RO:0002432. Repaired to RO:0001025--`UniProtKB	O95602	POLR1A	part_of	GO:0000785	PMID:23782956	IMP		C	DNA-directed RNA polymerase I subunit RPA1	POLR1A	protein	taxon:9606	20241221	ParkinsonsUK-UCL		UniProtKB:O95602
`