{ "summary": { "current": { "release_date": "2026-05-19", "valid_terms": 38263, "obsolete_terms": 10058, "merged_terms": 2434, "biological_process_terms": 24136, "molecular_function_terms": 10052, "cellular_component_terms": 4075, "meta_statements": 258977, "cross_references": 29549, "terms_relations": 74018 }, "previous": { "release_date": "2026-03-25", "valid_terms": 38560, "obsolete_terms": 9731, "merged_terms": 2434, "biological_process_terms": 24428, "molecular_function_terms": 10056, "cellular_component_terms": 4076, "meta_statements": 260935, "cross_references": 28690, "terms_relations": 74905 }, "changes": { "created_terms": 30, "valid_terms": -297, "obsolete_terms": 328, "merged_terms": 0, "biological_process_terms": -292, "molecular_function_terms": -4, "cellular_component_terms": -1, "meta_statements": 198, "meta_statements_by_term": 118, "cross_references": 1304, "cross_references_by_term": 260, "relations": 600, "relations_by_term": 586 } }, "detailed_changes": { "created_terms": { "biological_process": [ { "id": "GO:0120576", "name": "1,2-dehydro-N-beta-alanyldopamine biosynthetic process" }, { "id": "GO:0120577", "name": "1,2-dehydro-N-acetyldopamine biosynthetic process" }, { "id": "GO:0140402", "name": "symbiont-mediated disassembly of host stress granules" }, { "id": "GO:0140411", "name": "symbiont-mediated suppression of host stress granule assembly" }, { "id": "GO:0140422", "name": "symbiont-mediated suppression of host immunothrombosis" }, { "id": "GO:0140424", "name": "symbiont-mediated activation of blood coagulation, intrinsic pathway" }, { "id": "GO:7770057", "name": "copper ion import into Golgi lumen" }, { "id": "GO:7770058", "name": "mitochondrial protein import pathway" }, { "id": "GO:7770059", "name": "alpha helical protein insertion into mitochondrial outer membrane" }, { "id": "GO:7770060", "name": "TOM-TIM23-SORT-mediated protein insertion into the mitochondrial inner membrane" }, { "id": "GO:7770061", "name": "TOM-TIM22-mediated mitochondrial inner membrane protein insertion" }, { "id": "GO:7770063", "name": "beta barrel protein insertion into mitochondrial outer membrane" }, { "id": "GO:7770069", "name": "ferritinophagy" }, { "id": "GO:7770071", "name": "venom-mediated activation of inflammatory response" }, { "id": "GO:7770074", "name": "protein O-linked glycosylation via N-acetylglucosamine" }, { "id": "GO:7770075", "name": "venom-mediated leukocyte infiltration" }, { "id": "GO:7770076", "name": "venom-mediated release of inflammatory mediator" } ], "molecular_function": [ { "id": "GO:0140401", "name": "4-phosphoerythronate phosphatase activity" }, { "id": "GO:0140427", "name": "crotonobetainyl-CoA hydratase activity" }, { "id": "GO:0160321", "name": "vesicle docking activity" }, { "id": "GO:7770062", "name": "vesicle membrane tethering activity" }, { "id": "GO:7770064", "name": "actin-filament cross-linking activity" }, { "id": "GO:7770065", "name": "peroxisome-chloroplast membrane tether activity" }, { "id": "GO:7770066", "name": "endoplasmic reticulum-vacuole tether activity" }, { "id": "GO:7770067", "name": "contractile vacuole-plasma membrane tether activity" }, { "id": "GO:7770068", "name": "ferric iron reductase activity" }, { "id": "GO:7770072", "name": "double-stranded RNA immune receptor activity" }, { "id": "GO:7770073", "name": "left-handed Z-RNA immune receptor activity" } ], "cellular_component": [ { "id": "GO:0140419", "name": "cytoplasmic lattice complex" }, { "id": "GO:7770070", "name": "p24 cargo receptor complex" } ] }, "obsolete_terms": { "biological_process": [ { "id": "GO:0000052", "name": "citrulline metabolic process" }, { "id": "GO:0000750", "name": "pheromone-dependent signal transduction involved in conjugation with cellular fusion" }, { "id": "GO:0000947", "name": "amino acid catabolic process to alcohol via Ehrlich pathway" }, { "id": "GO:0000948", "name": "amino acid catabolic process to carboxylic acid via Ehrlich pathway" }, { "id": "GO:0000949", "name": "aromatic amino acid family catabolic process to alcohol via Ehrlich pathway" }, { "id": "GO:0000950", "name": "branched-chain amino acid catabolic process to alcohol via Ehrlich pathway" }, { "id": "GO:0000952", "name": "aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway" }, { "id": "GO:0000953", "name": "branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway" }, { "id": "GO:0000955", "name": "amino acid catabolic process via Ehrlich pathway" }, { "id": "GO:0003400", "name": "regulation of COPII vesicle coating" }, { "id": "GO:0006082", "name": "organic acid metabolic process" }, { "id": "GO:0006176", "name": "dATP biosynthetic process from ADP" }, { "id": "GO:0006187", "name": "dGTP biosynthetic process from dGDP" }, { "id": "GO:0006201", "name": "GMP catabolic process to IMP" }, { "id": "GO:0006202", "name": "GMP catabolic process to guanine" }, { "id": "GO:0006528", "name": "asparagine metabolic process" }, { "id": "GO:0006549", "name": "isoleucine metabolic process" }, { "id": "GO:0006558", "name": "L-phenylalanine metabolic process" }, { "id": "GO:0006568", "name": "L-tryptophan metabolic process" }, { "id": "GO:0006570", "name": "tyrosine metabolic process" }, { "id": "GO:0006573", "name": "valine metabolic process" }, { "id": "GO:0006587", "name": "serotonin biosynthetic process from L-tryptophan" }, { "id": "GO:0006782", "name": "protoporphyrinogen IX biosynthetic process" }, { "id": "GO:0006837", "name": "serotonin transport" }, { "id": "GO:0006903", "name": "vesicle targeting" }, { "id": "GO:0006904", "name": "vesicle docking involved in exocytosis" }, { "id": "GO:0007263", "name": "nitric oxide mediated signal transduction" }, { "id": "GO:0009095", "name": "aromatic amino acid family biosynthetic process, prephenate pathway" }, { "id": "GO:0009255", "name": "Entner-Doudoroff pathway through 6-phosphogluconate" }, { "id": "GO:0009442", "name": "allantoin assimilation pathway" }, { "id": "GO:0009448", "name": "GABA metabolic process" }, { "id": "GO:0009848", "name": "indoleacetic acid biosynthetic process via tryptophan" }, { "id": "GO:0009849", "name": "tryptophan-independent indoleacetic acid biosynthetic process" }, { "id": "GO:0010128", "name": "benzoate catabolic process via CoA ligation" }, { "id": "GO:0010134", "name": "sulfate assimilation via adenylyl sulfate reduction" }, { "id": "GO:0010144", "name": "pyridoxal phosphate biosynthetic process from pyridoxamine" }, { "id": "GO:0010381", "name": "peroxisome-chloroplast membrane tethering" }, { "id": "GO:0010514", "name": "induction of conjugation with cellular fusion" }, { "id": "GO:0010515", "name": "negative regulation of induction of conjugation with cellular fusion" }, { "id": "GO:0010749", "name": "regulation of nitric oxide mediated signal transduction" }, { "id": "GO:0010750", "name": "positive regulation of nitric oxide mediated signal transduction" }, { "id": "GO:0010751", "name": "negative regulation of nitric oxide mediated signal transduction" }, { "id": "GO:0010785", "name": "clathrin coating of Golgi vesicle, plasma membrane to endosome targeting" }, { "id": "GO:0010969", "name": "regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion" }, { "id": "GO:0015695", "name": "organic cation transport" }, { "id": "GO:0015711", "name": "organic anion transport" }, { "id": "GO:0015844", "name": "monoamine transport" }, { "id": "GO:0015872", "name": "dopamine transport" }, { "id": "GO:0015874", "name": "norepinephrine transport" }, { "id": "GO:0016053", "name": "organic acid biosynthetic process" }, { "id": "GO:0016054", "name": "organic acid catabolic process" }, { "id": "GO:0016080", "name": "synaptic vesicle targeting" }, { "id": "GO:0016081", "name": "synaptic vesicle docking" }, { "id": "GO:0018339", "name": "peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid" }, { "id": "GO:0018956", "name": "phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene" }, { "id": "GO:0018957", "name": "phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene" }, { "id": "GO:0019245", "name": "pyruvate fermentation to D(-)-lactate" }, { "id": "GO:0019246", "name": "pyruvate fermentation to L(+)-lactate" }, { "id": "GO:0019250", "name": "aerobic cobalamin biosynthetic process" }, { "id": "GO:0019251", "name": "anaerobic cobalamin biosynthetic process" }, { "id": "GO:0019285", "name": "glycine betaine biosynthetic process from choline" }, { "id": "GO:0019286", "name": "glycine betaine biosynthetic process from glycine" }, { "id": "GO:0019328", "name": "anaerobic gallate catabolic process" }, { "id": "GO:0019352", "name": "protoporphyrinogen IX biosynthetic process from glycine" }, { "id": "GO:0019353", "name": "protoporphyrinogen IX biosynthetic process from glutamate" }, { "id": "GO:0019360", "name": "nicotinamide nucleotide biosynthetic process from niacinamide" }, { "id": "GO:0019379", "name": "sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)" }, { "id": "GO:0019393", "name": "glucarate biosynthetic process" }, { "id": "GO:0019397", "name": "gallate catabolic process via 2-pyrone-4,6-dicarboxylate" }, { "id": "GO:0019398", "name": "gallate catabolic process via gallate dioxygenase activity" }, { "id": "GO:0019415", "name": "acetate biosynthetic process from carbon monoxide" }, { "id": "GO:0019423", "name": "sulfur oxidation, ferric ion-dependent" }, { "id": "GO:0019482", "name": "beta-alanine metabolic process" }, { "id": "GO:0019488", "name": "ribitol catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019512", "name": "lactose catabolic process via tagatose-6-phosphate" }, { "id": "GO:0019513", "name": "lactose catabolic process, using glucoside 3-dehydrogenase" }, { "id": "GO:0019515", "name": "lactose catabolic process via UDP-galactose" }, { "id": "GO:0019528", "name": "D-arabitol catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019569", "name": "L-arabinose catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019570", "name": "L-arabinose catabolic process to 2-oxoglutarate" }, { "id": "GO:0019573", "name": "D-arabinose catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019584", "name": "galactonate catabolic process" }, { "id": "GO:0019589", "name": "anaerobic glycerol catabolic process to 1,3-propanediol and glycerone phosphate" }, { "id": "GO:0019590", "name": "L-arabitol catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019597", "name": "(R)-mandelate catabolic process to benzoate" }, { "id": "GO:0019598", "name": "(R)-mandelate catabolic process to catechol" }, { "id": "GO:0019601", "name": "toluene oxidation via 2-hydroxytoluene" }, { "id": "GO:0019602", "name": "toluene oxidation via 3-hydroxytoluene" }, { "id": "GO:0019603", "name": "toluene oxidation via 4-hydroxytoluene" }, { "id": "GO:0019604", "name": "toluene oxidation to catechol" }, { "id": "GO:0019621", "name": "creatinine catabolic process to formate" }, { "id": "GO:0019623", "name": "atrazine catabolic process to urea" }, { "id": "GO:0019624", "name": "atrazine catabolic process to isopropylamine" }, { "id": "GO:0019625", "name": "atrazine catabolic process to cyanuric acid" }, { "id": "GO:0019640", "name": "D-glucuronate catabolic process to D-xylulose 5-phosphate" }, { "id": "GO:0019647", "name": "formaldehyde assimilation via ribulose monophosphate cycle" }, { "id": "GO:0019648", "name": "formaldehyde assimilation via xylulose monophosphate cycle" }, { "id": "GO:0019651", "name": "citrate fermentation to diacetyl" }, { "id": "GO:0019672", "name": "acetyl-CoA fermentation to butyrate" }, { "id": "GO:0019687", "name": "pyruvate biosynthetic process from acetate" }, { "id": "GO:0019696", "name": "toluene oxidation via toluene-cis-1,2-dihydrodiol" }, { "id": "GO:0031388", "name": "organic acid phosphorylation" }, { "id": "GO:0032005", "name": "signal transduction involved in positive regulation of conjugation with cellular fusion" }, { "id": "GO:0032917", "name": "polyamine acetylation" }, { "id": "GO:0032918", "name": "spermidine acetylation" }, { "id": "GO:0032919", "name": "spermine acetylation" }, { "id": "GO:0032920", "name": "putrescine acetylation" }, { "id": "GO:0033311", "name": "chlorophyll a biosynthetic process via phytyl diphosphate" }, { "id": "GO:0033312", "name": "chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a" }, { "id": "GO:0033323", "name": "choline biosynthetic process via CDP-choline" }, { "id": "GO:0033324", "name": "choline biosynthetic process via N-monomethylethanolamine" }, { "id": "GO:0033325", "name": "choline biosynthetic process via phosphoryl-ethanolamine" }, { "id": "GO:0033387", "name": "putrescine biosynthetic process from arginine, via ornithine" }, { "id": "GO:0033388", "name": "putrescine biosynthetic process from arginine" }, { "id": "GO:0033389", "name": "putrescine biosynthetic process from arginine, via agmatine" }, { "id": "GO:0033390", "name": "putrescine biosynthetic process from arginine via N-carbamoylputrescine" }, { "id": "GO:0033393", "name": "homogalacturonan catabolic process" }, { "id": "GO:0033476", "name": "indoleacetic acid ester conjugate biosynthetic process" }, { "id": "GO:0033488", "name": "cholesterol biosynthetic process via 24,25-dihydrolanosterol" }, { "id": "GO:0033489", "name": "cholesterol biosynthetic process via desmosterol" }, { "id": "GO:0033490", "name": "cholesterol biosynthetic process via lathosterol" }, { "id": "GO:0033506", "name": "glucosinolate biosynthetic process from homomethionine" }, { "id": "GO:0033507", "name": "glucosinolate biosynthetic process from phenylalanine" }, { "id": "GO:0033526", "name": "tetrapyrrole biosynthetic process from glutamate" }, { "id": "GO:0033527", "name": "tetrapyrrole biosynthetic process from glycine and succinyl-CoA" }, { "id": "GO:0033537", "name": "ajugose biosynthetic process using galactinol:raffinose galactosyltransferase" }, { "id": "GO:0033538", "name": "ajugose biosynthetic process using galactan:galactan galactosyltransferase" }, { "id": "GO:0033541", "name": "fatty acid beta-oxidation, unsaturated, odd number" }, { "id": "GO:0033542", "name": "fatty acid beta-oxidation, unsaturated, even number" }, { "id": "GO:0033543", "name": "fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway" }, { "id": "GO:0033544", "name": "fatty acid beta-oxidation, unsaturated, even number, epimerase pathway" }, { "id": "GO:0033545", "name": "myo-inositol hexakisphosphate biosynthetic process, lipid-dependent" }, { "id": "GO:0033546", "name": "myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate" }, { "id": "GO:0033548", "name": "myo-inositol hexakisphosphate biosynthetic process, lipid-independent" }, { "id": "GO:0036008", "name": "sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate" }, { "id": "GO:0036506", "name": "maintenance of unfolded protein" }, { "id": "GO:0042195", "name": "aerobic gallate catabolic process" }, { "id": "GO:0042210", "name": "octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol" }, { "id": "GO:0043438", "name": "acetoacetic acid metabolic process" }, { "id": "GO:0043441", "name": "acetoacetic acid biosynthetic process" }, { "id": "GO:0043442", "name": "acetoacetic acid catabolic process" }, { "id": "GO:0043640", "name": "benzoate catabolic process via hydroxylation" }, { "id": "GO:0044579", "name": "butyryl-CoA biosynthetic process from acetyl-CoA" }, { "id": "GO:0044581", "name": "butyryl-CoA catabolic process to butyrate" }, { "id": "GO:0044582", "name": "butyryl-CoA catabolic process to butanol" }, { "id": "GO:0045479", "name": "vesicle targeting to fusome" }, { "id": "GO:0046180", "name": "ketogluconate biosynthetic process" }, { "id": "GO:0046181", "name": "ketogluconate catabolic process" }, { "id": "GO:0046327", "name": "glycerol biosynthetic process from pyruvate" }, { "id": "GO:0046482", "name": "para-aminobenzoic acid metabolic process" }, { "id": "GO:0046501", "name": "protoporphyrinogen IX metabolic process" }, { "id": "GO:0048199", "name": "vesicle targeting, to, from or within Golgi" }, { "id": "GO:0048201", "name": "vesicle targeting, plasma membrane to endosome" }, { "id": "GO:0048203", "name": "vesicle targeting, trans-Golgi to endosome" }, { "id": "GO:0048204", "name": "vesicle targeting, inter-Golgi cisterna" }, { "id": "GO:0048206", "name": "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" }, { "id": "GO:0048207", "name": "vesicle targeting, rough ER to cis-Golgi" }, { "id": "GO:0048209", "name": "regulation of vesicle targeting, to, from or within Golgi" }, { "id": "GO:0048211", "name": "Golgi vesicle docking" }, { "id": "GO:0048241", "name": "epinephrine transport" }, { "id": "GO:0048278", "name": "vesicle docking" }, { "id": "GO:0051483", "name": "terpenoid biosynthetic process, mevalonate-independent" }, { "id": "GO:0051485", "name": "terpenoid biosynthetic process, mevalonate-dependent" }, { "id": "GO:0051519", "name": "activation of bipolar cell growth" }, { "id": "GO:0051937", "name": "catecholamine transport" }, { "id": "GO:0052698", "name": "ergothioneine metabolic process" }, { "id": "GO:0052704", "name": "ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide" }, { "id": "GO:0052786", "name": "alpha-linked polysaccharide catabolism to maltotriose" }, { "id": "GO:0052787", "name": "alpha-linked polysaccharide catabolism to maltopentaose" }, { "id": "GO:0052889", "name": "9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene" }, { "id": "GO:0060986", "name": "endocrine hormone secretion" }, { "id": "GO:0061610", "name": "glycerol catabolic process to glycerone phosphate" }, { "id": "GO:0061624", "name": "fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate" }, { "id": "GO:0061679", "name": "Entner-Doudoroff pathway through gluconate" }, { "id": "GO:0061680", "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde" }, { "id": "GO:0061681", "name": "Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate" }, { "id": "GO:0061688", "name": "glycolytic process via Entner-Doudoroff Pathway" }, { "id": "GO:0061705", "name": "sucrose catabolic process to fructose-6-phosphate through glucose and fructose" }, { "id": "GO:0061719", "name": "glucose catabolic process to pyruvate utilizing ADP" }, { "id": "GO:0061720", "name": "6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde" }, { "id": "GO:0061721", "name": "6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)" }, { "id": "GO:0061728", "name": "GDP-mannose biosynthetic process from mannose" }, { "id": "GO:0061729", "name": "GDP-D-mannose biosynthetic process from fructose-6-phosphate" }, { "id": "GO:0061790", "name": "dense core granule docking" }, { "id": "GO:0061817", "name": "endoplasmic reticulum-plasma membrane tethering" }, { "id": "GO:0062095", "name": "endoplasmic reticulum-peroxisome tethering" }, { "id": "GO:0070189", "name": "kynurenine metabolic process" }, { "id": "GO:0070220", "name": "aerobic sulfur oxidation" }, { "id": "GO:0070221", "name": "sulfide oxidation, using sulfide:quinone oxidoreductase" }, { "id": "GO:0070222", "name": "sulfide oxidation, using sulfide dehydrogenase" }, { "id": "GO:0070223", "name": "sulfide oxidation, using sulfur dioxygenase" }, { "id": "GO:0070275", "name": "aerobic ammonia oxidation to nitrite via pyruvic oxime" }, { "id": "GO:0070680", "name": "asparaginyl-tRNAAsn biosynthesis via transamidation" }, { "id": "GO:0070832", "name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline" }, { "id": "GO:0070833", "name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine" }, { "id": "GO:0070834", "name": "phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine" }, { "id": "GO:0090029", "name": "negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion" }, { "id": "GO:0090384", "name": "phagosome-lysosome docking" }, { "id": "GO:0090522", "name": "vesicle tethering involved in exocytosis" }, { "id": "GO:0090531", "name": "L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose" }, { "id": "GO:0090532", "name": "L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate" }, { "id": "GO:0090611", "name": "ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway" }, { "id": "GO:0090638", "name": "phosphatidylcholine biosynthesis from phosphatidylethanolamine" }, { "id": "GO:0090639", "name": "phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol" }, { "id": "GO:0090640", "name": "phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine" }, { "id": "GO:0097053", "name": "L-kynurenine catabolic process" }, { "id": "GO:0097711", "name": "ciliary basal body-plasma membrane docking" }, { "id": "GO:0098881", "name": "exocytic insertion of neurotransmitter receptor to plasma membrane" }, { "id": "GO:0099022", "name": "vesicle tethering" }, { "id": "GO:0099041", "name": "vesicle tethering to Golgi" }, { "id": "GO:0099044", "name": "vesicle tethering to endoplasmic reticulum" }, { "id": "GO:0099069", "name": "synaptic vesicle tethering involved in synaptic vesicle exocytosis" }, { "id": "GO:0099148", "name": "regulation of synaptic vesicle docking" }, { "id": "GO:0106020", "name": "regulation of vesicle docking" }, { "id": "GO:0106021", "name": "negative regulation of vesicle docking" }, { "id": "GO:0106022", "name": "positive regulation of vesicle docking" }, { "id": "GO:0106047", "name": "polyamine deacetylation" }, { "id": "GO:0106048", "name": "spermidine deacetylation" }, { "id": "GO:0140025", "name": "contractile vacuole tethering involved in discharge" }, { "id": "GO:0140057", "name": "vacuole-mitochondria membrane tethering" }, { "id": "GO:0140479", "name": "ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase" }, { "id": "GO:0160249", "name": "glycogen biosynthetic process via UDP-glucose" }, { "id": "GO:0160250", "name": "glycogen biosynthetic process via ADP-glucose" }, { "id": "GO:0160251", "name": "glycogen catabolic process via dextrin" }, { "id": "GO:0160252", "name": "glycogen catabolic process via dextrin and maltose" }, { "id": "GO:1900237", "name": "positive regulation of induction of conjugation with cellular fusion" }, { "id": "GO:1900318", "name": "regulation of methane biosynthetic process from dimethylamine" }, { "id": "GO:1900319", "name": "negative regulation of methane biosynthetic process from dimethylamine" }, { "id": "GO:1900320", "name": "positive regulation of methane biosynthetic process from dimethylamine" }, { "id": "GO:1900330", "name": "regulation of methane biosynthetic process from trimethylamine" }, { "id": "GO:1900331", "name": "negative regulation of methane biosynthetic process from trimethylamine" }, { "id": "GO:1900332", "name": "positive regulation of methane biosynthetic process from trimethylamine" }, { "id": "GO:1900333", "name": "regulation of methane biosynthetic process from 3-(methylthio)propionic acid" }, { "id": "GO:1900334", "name": "negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid" }, { "id": "GO:1900335", "name": "positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid" }, { "id": "GO:1900336", "name": "regulation of methane biosynthetic process from carbon monoxide" }, { "id": "GO:1900337", "name": "negative regulation of methane biosynthetic process from carbon monoxide" }, { "id": "GO:1900338", "name": "positive regulation of methane biosynthetic process from carbon monoxide" }, { "id": "GO:1900339", "name": "regulation of methane biosynthetic process from formic acid" }, { "id": "GO:1900340", "name": "negative regulation of methane biosynthetic process from formic acid" }, { "id": "GO:1900341", "name": "positive regulation of methane biosynthetic process from formic acid" }, { "id": "GO:1900342", "name": "regulation of methane biosynthetic process from dimethyl sulfide" }, { "id": "GO:1900343", "name": "negative regulation of methane biosynthetic process from dimethyl sulfide" }, { "id": "GO:1900344", "name": "positive regulation of methane biosynthetic process from dimethyl sulfide" }, { "id": "GO:1900345", "name": "regulation of methane biosynthetic process from methanethiol" }, { "id": "GO:1900346", "name": "negative regulation of methane biosynthetic process from methanethiol" }, { "id": "GO:1900347", "name": "positive regulation of methane biosynthetic process from methanethiol" }, { "id": "GO:1900348", "name": "regulation of methane biosynthetic process from methylamine" }, { "id": "GO:1900349", "name": "negative regulation of methane biosynthetic process from methylamine" }, { "id": "GO:1900350", "name": "positive regulation of methane biosynthetic process from methylamine" }, { "id": "GO:1900494", "name": "regulation of butyryl-CoA biosynthetic process from acetyl-CoA" }, { "id": "GO:1900495", "name": "negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA" }, { "id": "GO:1900496", "name": "positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA" }, { "id": "GO:1900497", "name": "regulation of butyryl-CoA catabolic process to butanol" }, { "id": "GO:1900498", "name": "negative regulation of butyryl-CoA catabolic process to butanol" }, { "id": "GO:1900499", "name": "positive regulation of butyryl-CoA catabolic process to butanol" }, { "id": "GO:1900500", "name": "regulation of butyryl-CoA catabolic process to butyrate" }, { "id": "GO:1900501", "name": "negative regulation of butyryl-CoA catabolic process to butyrate" }, { "id": "GO:1900502", "name": "positive regulation of butyryl-CoA catabolic process to butyrate" }, { "id": "GO:1901056", "name": "trimethylenediamine catabolic process" }, { "id": "GO:1901157", "name": "neomycin catabolic process" }, { "id": "GO:1901410", "name": "regulation of tetrapyrrole biosynthetic process from glutamate" }, { "id": "GO:1901411", "name": "negative regulation of tetrapyrrole biosynthetic process from glutamate" }, { "id": "GO:1901412", "name": "positive regulation of tetrapyrrole biosynthetic process from glutamate" }, { "id": "GO:1901413", "name": "regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" }, { "id": "GO:1901414", "name": "negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" }, { "id": "GO:1901415", "name": "positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" }, { "id": "GO:1901605", "name": "alpha-amino acid metabolic process" }, { "id": "GO:1901606", "name": "alpha-amino acid catabolic process" }, { "id": "GO:1901607", "name": "alpha-amino acid biosynthetic process" }, { "id": "GO:1901791", "name": "3-(2,3-dihydroxyphenyl)propanoate catabolic process" }, { "id": "GO:1901803", "name": "1,5-anhydro-D-fructose biosynthetic process" }, { "id": "GO:1901814", "name": "astaxanthin catabolic process" }, { "id": "GO:1901823", "name": "delta-carotene catabolic process" }, { "id": "GO:1901829", "name": "zeaxanthin bis(beta-D-glucoside) catabolic process" }, { "id": "GO:1901832", "name": "all-trans-neoxanthin catabolic process" }, { "id": "GO:1901996", "name": "regulation of indoleacetic acid biosynthetic process via tryptophan" }, { "id": "GO:1902224", "name": "ketone body metabolic process" }, { "id": "GO:1902768", "name": "isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" }, { "id": "GO:1902924", "name": "poly(hydroxyalkanoate) biosynthetic process from glucose" }, { "id": "GO:1902925", "name": "poly(hydroxyalkanoate) biosynthetic process from fatty acid" }, { "id": "GO:1903184", "name": "L-dopa metabolic process" }, { "id": "GO:1903185", "name": "L-dopa biosynthetic process" }, { "id": "GO:1903195", "name": "regulation of L-dopa biosynthetic process" }, { "id": "GO:1903196", "name": "negative regulation of L-dopa biosynthetic process" }, { "id": "GO:1903197", "name": "positive regulation of L-dopa biosynthetic process" }, { "id": "GO:1903314", "name": "regulation of nitrogen cycle metabolic process" }, { "id": "GO:1903315", "name": "negative regulation of nitrogen cycle metabolic process" }, { "id": "GO:1903316", "name": "positive regulation of nitrogen cycle metabolic process" }, { "id": "GO:1904122", "name": "positive regulation of fatty acid beta-oxidation by octopamine signaling pathway" }, { "id": "GO:1904123", "name": "positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" }, { "id": "GO:1904538", "name": "regulation of glycolytic process through fructose-6-phosphate" }, { "id": "GO:1904735", "name": "regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" }, { "id": "GO:1904736", "name": "negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" }, { "id": "GO:1904737", "name": "positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" }, { "id": "GO:1905353", "name": "ciliary transition fiber assembly" }, { "id": "GO:1990456", "name": "mitochondrion-endoplasmic reticulum membrane tethering" }, { "id": "GO:1990489", "name": "anaerobic pectin catabolic process" }, { "id": "GO:1990491", "name": "methane biosynthetic process from methanol and hydrogen" }, { "id": "GO:1990854", "name": "vacuole-ER tethering" }, { "id": "GO:2001127", "name": "methane biosynthetic process from formic acid" }, { "id": "GO:2001128", "name": "methane biosynthetic process from methylamine" }, { "id": "GO:2001129", "name": "methane biosynthetic process from dimethylamine" }, { "id": "GO:2001130", "name": "methane biosynthetic process from trimethylamine" }, { "id": "GO:2001131", "name": "methane biosynthetic process from dimethyl sulfide" }, { "id": "GO:2001132", "name": "methane biosynthetic process from 3-(methylthio)propionic acid" }, { "id": "GO:2001133", "name": "methane biosynthetic process from methanethiol" }, { "id": "GO:2001134", "name": "methane biosynthetic process from carbon monoxide" }, { "id": "GO:7770032", "name": "tyramine transport" } ], "cellular_component": [ { "id": "GO:0005870", "name": "actin capping protein of dynactin complex" }, { "id": "GO:0035842", "name": "old cell tip after activation of bipolar cell growth" }, { "id": "GO:1990727", "name": "tubulin folding cofactor complex" } ], "molecular_function": [ { "id": "GO:0008374", "name": "O-acyltransferase activity" }, { "id": "GO:0008411", "name": "4-hydroxybutyrate CoA-transferase activity" }, { "id": "GO:0008785", "name": "alkyl hydroperoxide reductase activity" }, { "id": "GO:0008875", "name": "gluconate dehydrogenase activity" }, { "id": "GO:0016408", "name": "C-acyltransferase activity" }, { "id": "GO:0016410", "name": "N-acyltransferase activity" }, { "id": "GO:0016417", "name": "S-acyltransferase activity" }, { "id": "GO:0018581", "name": "hydroxyquinol 1,2-dioxygenase activity" }, { "id": "GO:0031249", "name": "denatured protein binding" }, { "id": "GO:0043713", "name": "(R)-2-hydroxyisocaproate dehydrogenase activity" }, { "id": "GO:0045550", "name": "geranylgeranyl reductase activity" }, { "id": "GO:0046715", "name": "active borate transmembrane transporter activity" }, { "id": "GO:0047407", "name": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity" }, { "id": "GO:0047468", "name": "phosphoglucomutase (glucose-cofactor) activity" }, { "id": "GO:0051082", "name": "unfolded protein binding" }, { "id": "GO:7770028", "name": "glycoprotein cargo receptor activity" } ] }, "merged_terms": {}, "meta_statements": { "cellular_component": [ { "id": "GO:0000145", "name": "exocyst", "changes": { "definition": { "current": "\"A vesicle tethering complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.\" [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]", "previous": "\"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.\" [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]" } } }, { "id": "GO:0005576", "name": "extracellular region", "changes": { "comment": { "current": "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products at the cell surface, consider annotating to external side of plasma membrane ; GO:0009897.", "previous": "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." } } }, { "id": "GO:0017109", "name": "glutamate-cysteine ligase complex", "changes": { "definition": { "current": "\"An enzyme complex that catalyzes the ligation of L-glutamate to L-cysteine, forming gamma-L-glutamyl-L-cysteine.\" [PMID:9675072]", "previous": "\"An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.\" [PMID:9675072]" } } }, { "id": "GO:0061852", "name": "retrograde cargo receptor complex, Golgi to ER", "changes": { "name": { "current": "retrograde cargo receptor complex, Golgi to ER", "previous": "retrograde transporter complex, Golgi to ER" }, "definition": { "current": "\"Cargo receptor complex that recognizes, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.\" [GOC:bhm, PMID:16093310]", "previous": "\"Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles.\" [GOC:bhm, PMID:16093310]" }, "synonyms": { "current": [ "\"ERV41-ERV46 retrograde receptor complex\" NARROW []", "\"retrograde cargo receptor complex, Golgi to endoplasmic reticulum\" EXACT []", "\"retrograde receptor complex, Golgi to endoplasmic reticulum\" EXACT []", "\"retrograde receptor complex, Golgi to ER\" EXACT []", "\"retrograde transporter complex, Golgi to ER\" BROAD []" ], "previous": [ "\"ERV41-ERV46 retrograde receptor complex\" NARROW []", "\"retrograde receptor complex, Golgi to endoplasmic reticulum\" EXACT []", "\"retrograde receptor complex, Golgi to ER\" EXACT []", "\"retrograde transporter complex, Golgi to endoplasmic reticulum\" EXACT []" ] } } }, { "id": "GO:1990334", "name": "SIN/MEN two-component GAP complex", "changes": { "name": { "current": "SIN/MEN two-component GAP complex", "previous": "Bfa1-Bub2 complex" }, "definition": { "current": "\"A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation.\" [GOC:bhm, PMID:16449187]", "previous": "\"A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.\" [GOC:bhm, PMID:16449187]" }, "synonyms": { "current": [ "\"Bfa1-Bub2 complex\" NARROW []", "\"Byr4-Cdc16 GAP complex\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:1990819", "name": "mating projection actin fusion focus", "changes": { "definition": { "current": "\"A focus at the mating projection tip where the cell wall is degraded during cytogamy. Actin filaments form an aster-like structure from this location.\" [PMID:25825517]", "previous": "\"A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.\" [PMID:25825517]" } } } ], "biological_process": [ { "id": "GO:0000256", "name": "allantoin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.\" [PMID:41016821]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.\" [GOC:mah, ISBN:0198547684]" }, "synonyms": { "current": [ "\"allantoin assimilation\" EXACT []", "\"allantoin breakdown\" EXACT []", "\"allantoin catabolism\" EXACT []", "\"allantoin degradation\" EXACT []" ], "previous": [ "\"allantoin breakdown\" EXACT []", "\"allantoin catabolism\" EXACT []", "\"allantoin degradation\" EXACT []" ] } } }, { "id": "GO:0002143", "name": "tRNA wobble position uridine thiolation", "changes": { "definition": { "current": "\"The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.\" [PMID:16871210]", "previous": "\"The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.\" [PMID:16871210]" } } }, { "id": "GO:0006041", "name": "D-glucosamine metabolic process", "changes": { "name": { "current": "D-glucosamine metabolic process", "previous": "glucosamine metabolic process" }, "synonyms": { "current": [ "\"chitosamine metabolic process\" EXACT []", "\"chitosamine metabolism\" EXACT []", "\"glucosamine metabolic process\" EXACT []", "\"glucosamine metabolism\" EXACT []" ], "previous": [ "\"chitosamine metabolic process\" EXACT []", "\"chitosamine metabolism\" EXACT []", "\"glucosamine metabolism\" EXACT []" ] } } }, { "id": "GO:0006042", "name": "D-glucosamine biosynthetic process", "changes": { "name": { "current": "D-glucosamine biosynthetic process", "previous": "glucosamine biosynthetic process" }, "synonyms": { "current": [ "\"chitosamine biosynthesis\" EXACT []", "\"chitosamine biosynthetic process\" EXACT []", "\"glucosamine anabolism\" EXACT []", "\"glucosamine biosynthesis\" EXACT []", "\"glucosamine biosynthetic process\" EXACT []", "\"glucosamine formation\" EXACT []", "\"glucosamine synthesis\" EXACT []" ], "previous": [ "\"chitosamine biosynthesis\" EXACT []", "\"chitosamine biosynthetic process\" EXACT []", "\"glucosamine anabolism\" EXACT []", "\"glucosamine biosynthesis\" EXACT []", "\"glucosamine formation\" EXACT []", "\"glucosamine synthesis\" EXACT []" ] } } }, { "id": "GO:0006043", "name": "D-glucosamine catabolic process", "changes": { "name": { "current": "D-glucosamine catabolic process", "previous": "glucosamine catabolic process" }, "synonyms": { "current": [ "\"chitosamine catabolic process\" EXACT []", "\"chitosamine catabolism\" EXACT []", "\"glucosamine breakdown\" EXACT []", "\"glucosamine catabolic process\" EXACT []", "\"glucosamine catabolism\" EXACT []", "\"glucosamine degradation\" EXACT []" ], "previous": [ "\"chitosamine catabolic process\" EXACT []", "\"chitosamine catabolism\" EXACT []", "\"glucosamine breakdown\" EXACT []", "\"glucosamine catabolism\" EXACT []", "\"glucosamine degradation\" EXACT []" ] } } }, { "id": "GO:0006423", "name": "cysteinyl-tRNA aminoacylation", "changes": { "definition": { "current": "\"The process of coupling L-cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.\" [GOC:mcc, ISBN:0716730510]", "previous": "\"The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.\" [GOC:mcc, ISBN:0716730510]" } } }, { "id": "GO:0006550", "name": "L-isoleucine catabolic process", "changes": { "synonyms": { "current": [ "\"isoleucine breakdown\" EXACT []", "\"isoleucine catabolism\" EXACT []", "\"isoleucine degradation\" EXACT []", "\"L-isoleucine catabolic process via Ehrlich pathway\" NARROW []", "\"L-isoleucine degradation via Ehrlich pathway\" NARROW []" ], "previous": [ "\"isoleucine breakdown\" EXACT []", "\"isoleucine catabolism\" EXACT []", "\"isoleucine degradation\" EXACT []" ] } } }, { "id": "GO:0006552", "name": "L-leucine catabolic process", "changes": { "synonyms": { "current": [ "\"L-leucine breakdown\" EXACT []", "\"L-leucine catabolism\" EXACT []", "\"L-leucine degradation\" EXACT []", "\"L-leucine degradation via Ehrlich pathway\" NARROW []", "\"L-methionine catabolic process via Ehrlich pathway\" NARROW []", "\"leucine catabolic process\" BROAD []" ], "previous": [ "\"L-leucine breakdown\" EXACT []", "\"L-leucine catabolism\" EXACT []", "\"L-leucine degradation\" EXACT []", "\"leucine catabolic process\" BROAD []" ] } } }, { "id": "GO:0006559", "name": "L-phenylalanine catabolic process", "changes": { "synonyms": { "current": [ "\"L-phenylalanine breakdown\" EXACT []", "\"L-phenylalanine catabolic process via Ehrlich pathway\" NARROW []", "\"L-phenylalanine catabolism\" EXACT []", "\"L-phenylalanine degradation\" EXACT []", "\"L-phenylalanine degradation via Ehrlich pathway\" NARROW []", "\"phenylalanine catabolic process\" BROAD []", "\"phenylalanine catabolism\" BROAD []" ], "previous": [ "\"L-phenylalanine breakdown\" EXACT []", "\"L-phenylalanine catabolism\" EXACT []", "\"L-phenylalanine degradation\" EXACT []", "\"phenylalanine catabolic process\" BROAD []", "\"phenylalanine catabolism\" BROAD []" ] } } }, { "id": "GO:0006569", "name": "L-tryptophan catabolic process", "changes": { "synonyms": { "current": [ "\"L-tryptophan catabolic process via Ehrlich pathway\" NARROW []", "\"L-tryptophan degradation via Ehrlich pathway\" NARROW []", "\"tryptophan breakdown\" EXACT []", "\"tryptophan catabolic process\" RELATED []", "\"tryptophan catabolic process, using tryptophanase\" NARROW []", "\"tryptophan catabolism\" EXACT []", "\"tryptophan catabolism, using tryptophanase\" NARROW []", "\"tryptophan degradation\" EXACT []" ], "previous": [ "\"tryptophan breakdown\" EXACT []", "\"tryptophan catabolic process\" RELATED []", "\"tryptophan catabolic process, using tryptophanase\" NARROW []", "\"tryptophan catabolism\" EXACT []", "\"tryptophan catabolism, using tryptophanase\" NARROW []", "\"tryptophan degradation\" EXACT []" ] } } }, { "id": "GO:0006574", "name": "L-valine catabolic process", "changes": { "synonyms": { "current": [ "\"valine breakdown\" EXACT []", "\"valine catabolism\" EXACT []", "\"valine degradation\" EXACT []", "\"valine degradation via Ehrlich pathway\" NARROW []" ], "previous": [ "\"valine breakdown\" EXACT []", "\"valine catabolism\" EXACT []", "\"valine degradation\" EXACT []" ] } } }, { "id": "GO:0006583", "name": "melanin biosynthetic process from tyrosine", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine.\" [GOC:curators]" } } }, { "id": "GO:0006592", "name": "L-ornithine biosynthetic process", "changes": { "name": { "current": "L-ornithine biosynthetic process", "previous": "ornithine biosynthetic process" }, "synonyms": { "current": [ "\"ornithine anabolism\" EXACT []", "\"ornithine biosynthesis\" EXACT []", "\"ornithine biosynthetic process\" BROAD []", "\"ornithine formation\" EXACT []", "\"ornithine synthesis\" EXACT []" ], "previous": [ "\"ornithine anabolism\" EXACT []", "\"ornithine biosynthesis\" EXACT []", "\"ornithine formation\" EXACT []", "\"ornithine synthesis\" EXACT []" ] } } }, { "id": "GO:0006598", "name": "polyamine catabolic process", "changes": { "synonyms": { "current": [ "\"polyamine back-conversion\" RELATED []", "\"polyamine breakdown\" EXACT []", "\"polyamine catabolism\" EXACT []", "\"polyamine degradation\" EXACT []", "\"polyamine interconversion\" RELATED []" ], "previous": [ "\"polyamine breakdown\" EXACT []", "\"polyamine catabolism\" EXACT []", "\"polyamine degradation\" EXACT []" ] } } }, { "id": "GO:0006727", "name": "ommochrome biosynthetic process", "changes": { "synonyms": { "current": [ "\"kynurenine pathway\" BROAD []", "\"ommochrome anabolism\" EXACT []", "\"ommochrome biosynthesis\" EXACT []", "\"ommochrome formation\" EXACT []", "\"ommochrome synthesis\" EXACT []" ], "previous": [ "\"ommochrome anabolism\" EXACT []", "\"ommochrome biosynthesis\" EXACT []", "\"ommochrome formation\" EXACT []", "\"ommochrome synthesis\" EXACT []" ] } } }, { "id": "GO:0006901", "name": "vesicle coat assembly", "changes": { "name": { "current": "vesicle coat assembly", "previous": "vesicle coating" }, "synonyms": { "current": [ "\"vesicle coating\" EXACT []" ], "previous": [ "\"vesicle coat assembly\" BROAD []" ] } } }, { "id": "GO:0008153", "name": "4-aminobenzoate biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]", "previous": "\"The chemical reactions and pathways resulting in the formation of 4-aminobenzoate, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.\" [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743]" } } }, { "id": "GO:0008354", "name": "primordial germ cell migration", "changes": { "name": { "current": "primordial germ cell migration", "previous": "germ cell migration" }, "synonyms": { "current": [ "\"embryonic germ cell migration\" EXACT []", "\"germ cell migration\" BROAD []", "\"germ-cell migration\" BROAD []", "\"pole cell migration\" NARROW []" ], "previous": [ "\"germ-cell migration\" EXACT []", "\"pole cell migration\" NARROW []", "\"primordial germ cell migration\" RELATED []" ] } } }, { "id": "GO:0009067", "name": "aspartate family amino acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-aspartate or any of the amino acids synthesised from it (L-asparagine, L-lysine, L-methionine, L-threonine and L-isoleucine).\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.\" [GOC:ai]" } } }, { "id": "GO:0009070", "name": "serine family amino acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of an amino acid derived from 3-phosphoglycerate (L-serine, glycine, L-cysteine and L-homocysteine).\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.\" [GOC:ai]" } } }, { "id": "GO:0009073", "name": "aromatic amino acid biosynthetic process", "changes": { "name": { "current": "aromatic amino acid biosynthetic process", "previous": "aromatic amino acid family biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of an amino acid whose structure includes an aromatic ring.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).\" [GOC:curators]" } } }, { "id": "GO:0009074", "name": "aromatic amino acid catabolic process", "changes": { "name": { "current": "aromatic amino acid catabolic process", "previous": "aromatic amino acid family catabolic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of an amino acid whose structure includes an aromatic ring.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).\" [GOC:curators]" } } }, { "id": "GO:0009079", "name": "pyruvate family amino acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of an L-amino acid derived from pyruvate (L-alanine, L-valine, and L-leucine).\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine.\" [GOC:jl]" } } }, { "id": "GO:0009084", "name": "glutamate family amino acid biosynthetic process", "changes": { "name": { "current": "glutamate family amino acid biosynthetic process", "previous": "L-glutamine family amino acid biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-glutamate or any of the amino acids synthesised from it (L-glutamine, L-proline and L-arginine).\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.\" [GOC:ai]" } } }, { "id": "GO:0009087", "name": "L-methionine catabolic process", "changes": { "synonyms": { "current": [ "\"L-methionine catabolic process via Ehrlich pathway\" NARROW []", "\"L-methionine degradation via Ehrlich pathway\" NARROW []", "\"methionine breakdown\" EXACT []", "\"methionine catabolism\" EXACT []", "\"methionine degradation\" EXACT []" ], "previous": [ "\"methionine breakdown\" EXACT []", "\"methionine catabolism\" EXACT []", "\"methionine degradation\" EXACT []" ] } } }, { "id": "GO:0009298", "name": "GDP-mannose biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.\" [MetaCyc:PWY-5659]", "previous": "\"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.\" [GOC:ai]" } } }, { "id": "GO:0009684", "name": "indoleacetic acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.\" [PMID:12620340]", "previous": "\"The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.\" [ISBN:0387969845]" } } }, { "id": "GO:0016266", "name": "protein O-linked glycosylation via N-acetylgalactosamine", "changes": { "name": { "current": "protein O-linked glycosylation via N-acetylgalactosamine", "previous": "protein O-linked glycosylation via N-acetyl-galactosamine" }, "synonyms": { "current": [ "\"core O-glycan biosynthetic process\" EXACT []", "\"mucin-type O-glycan synthesis\" NARROW []", "\"O-glycan processing\" EXACT []", "\"protein O-linked GalNAcylation\" RELATED []", "\"protein O-linked glycosylation via N-acetyl-galactosamine\" EXACT []" ], "previous": [ "\"core O-glycan biosynthetic process\" EXACT []", "\"mucin-type O-glycan synthesis\" NARROW []", "\"O-glycan processing\" EXACT []", "\"protein O-linked GalNAcylation\" RELATED []" ] } } }, { "id": "GO:0019240", "name": "L-citrulline biosynthetic process", "changes": { "name": { "current": "L-citrulline biosynthetic process", "previous": "citrulline biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of L-citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.\" [ISBN:0198506732]", "previous": "\"The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.\" [ISBN:0198506732]" }, "synonyms": { "current": [ "\"citrulline anabolism\" EXACT []", "\"citrulline biosynthesis\" EXACT []", "\"citrulline biosynthetic process\" BROAD []", "\"citrulline formation\" EXACT []", "\"citrulline synthesis\" EXACT []" ], "previous": [ "\"citrulline anabolism\" EXACT []", "\"citrulline biosynthesis\" EXACT []", "\"citrulline formation\" EXACT []", "\"citrulline synthesis\" EXACT []" ] } } }, { "id": "GO:0019244", "name": "pyruvate fermentation to lactate", "changes": { "definition": { "current": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into D-lactate or L-lactate.\" [GOC:curators]", "previous": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of pyruvate into lactate.\" [GOC:curators]" } } }, { "id": "GO:0019254", "name": "carnitine metabolic process, CoA-linked", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.\" [GOC:go_curators]", "previous": "\"The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.\" [GOC:curators]" } } }, { "id": "GO:0019418", "name": "sulfide oxidation", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the conversion of sufide to sulfite or sulfate.\" [MetaCyc:Sulfide-Oxidation]", "previous": "\"The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.\" [MetaCyc:Sulfide-Oxidation]" }, "synonyms": { "current": [ "\"hydrogen sulfide catabolic process\" EXACT []", "\"sulphide oxidation\" EXACT []" ], "previous": [ "\"sulphide oxidation\" EXACT []" ] } } }, { "id": "GO:0019596", "name": "(R)-mandelate catabolic process", "changes": { "name": { "current": "(R)-mandelate catabolic process", "previous": "mandelate catabolic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of (R)-mandelate, the anion of (R)-mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.\" [GOC:curators]" }, "synonyms": { "current": [ "\"mandelate breakdown\" EXACT []", "\"mandelate catabolic process\" BROAD []", "\"mandelate catabolism\" EXACT []", "\"mandelate degradation\" EXACT []" ], "previous": [ "\"mandelate breakdown\" EXACT []", "\"mandelate catabolism\" EXACT []", "\"mandelate degradation\" EXACT []" ] } } }, { "id": "GO:0030150", "name": "protein import into mitochondrial matrix", "changes": { "definition": { "current": "\"The import of proteins with mitochondrial targeting sequence from the cytosol across the mitochondrial outer and inner membranes into the matrix via TOM-TIM23-PAM.\" [ISBN:0716731363, PMID:36931257]", "previous": "\"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.\" [ISBN:0716731363]" }, "synonyms": { "current": [ "\"mitochondrial matrix protein import\" EXACT []", "\"mitochondrial translocation\" BROAD []", "\"protein transport into mitochondrial matrix\" EXACT []", "\"TOM-TIM23-PAM presequence matrix import pathway\" EXACT []" ], "previous": [ "\"mitochondrial matrix protein import\" EXACT []", "\"mitochondrial translocation\" BROAD []", "\"protein transport into mitochondrial matrix\" EXACT []" ] } } }, { "id": "GO:0030645", "name": "acetyl-CoA fermentation to butanoate", "changes": { "definition": { "current": "\"The anaerobic chemical reactions and pathways resulting in the breakdown of acetyl-CoA to butyrate, yielding energy in the form of ATP. Butanoate is secreted by the cell.\" [MetaCyc:PWY-5676]", "previous": "\"The anaerobic chemical reactions and pathways resulting in the production of acetic acid, butyric acid, and dihydrogen from acetyl-CoA; effected by some saccharolytic species of Clostridium, e.g. C. butyricum.\" [ISBN:0198506732, Metacyc:PWY-5676]" } } }, { "id": "GO:0033228", "name": "L-cysteine export across plasma membrane", "changes": { "name": { "current": "L-cysteine export across plasma membrane", "previous": "cysteine export across plasma membrane" }, "definition": { "current": "\"The directed movement of L-cysteine from inside of a cell, across the plasma membrane and into the extracellular region.\" [GOC:mlg]", "previous": "\"The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region.\" [GOC:mlg]" }, "synonyms": { "current": [ "\"cysteine export\" BROAD []", "\"cysteine export across plasma membrane\" BROAD []", "\"L-cysteine export\" BROAD []" ], "previous": [ "\"cysteine export\" BROAD []" ] } } }, { "id": "GO:0033499", "name": "beta-D-galactose catabolic process via UDP-galactose, Leloir pathway", "changes": { "name": { "current": "beta-D-galactose catabolic process via UDP-galactose, Leloir pathway", "previous": "galactose catabolic process via UDP-galactose, Leloir pathway" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of beta-D-galactose, via the intermediate UDP-galactose.\" [MetaCyc:PWY-6317]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.\" [GOC:mah]" }, "synonyms": { "current": [ "\"galactose breakdown via UDP-galactose\" EXACT []", "\"galactose catabolic process via UDP-galactose, Leloir pathway\" NARROW []", "\"galactose catabolism via UDP-galactose\" EXACT []", "\"galactose degradation via UDP-galactose\" EXACT []", "\"Leloir Pathway\" EXACT [PMID:14741191]" ], "previous": [ "\"galactose breakdown via UDP-galactose\" EXACT []", "\"galactose catabolism via UDP-galactose\" EXACT []", "\"galactose degradation via UDP-galactose\" EXACT []", "\"Leloir Pathway\" EXACT [PMID:14741191]" ] } } }, { "id": "GO:0034276", "name": "kynurenic acid biosynthetic process", "changes": { "synonyms": { "current": [ "\"4-hydroxyquinoline-2-carboxylic acid biosynthetic process\" EXACT []", "\"kynurenic acid anabolism\" EXACT []", "\"kynurenic acid biosynthesis\" EXACT []", "\"kynurenic acid formation\" RELATED []", "\"kynurenic acid synthesis\" EXACT []", "\"kynurenine pathway\" BROAD []" ], "previous": [ "\"4-hydroxyquinoline-2-carboxylic acid biosynthetic process\" EXACT []", "\"kynurenic acid anabolism\" EXACT []", "\"kynurenic acid biosynthesis\" EXACT []", "\"kynurenic acid formation\" RELATED []", "\"kynurenic acid synthesis\" EXACT []" ] } } }, { "id": "GO:0034354", "name": "'de novo' NAD+ biosynthetic process from L-tryptophan", "changes": { "synonyms": { "current": [ "\"'de novo' NAD biosynthetic process from L-tryptophan\" EXACT []", "\"'de novo' NAD biosynthetic process from tryptophan\" BROAD []", "\"de novo NAD biosynthetic process from tryptophan\" RELATED []", "\"kynurenine pathway\" BROAD []" ], "previous": [ "\"'de novo' NAD biosynthetic process from L-tryptophan\" EXACT []", "\"'de novo' NAD biosynthetic process from tryptophan\" BROAD []", "\"de novo NAD biosynthetic process from tryptophan\" RELATED []" ] } } }, { "id": "GO:0042883", "name": "L-cysteine transport", "changes": { "name": { "current": "L-cysteine transport", "previous": "cysteine transport" }, "definition": { "current": "\"The directed movement of L-cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\" [GOC:jl, ISBN:0198506732]", "previous": "\"The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\" [GOC:jl, ISBN:0198506732]" }, "synonyms": { "current": [ "\"cysteine transport\" BROAD []" ], "previous": [ "\"L-cysteine transport\" NARROW []" ] } } }, { "id": "GO:0043639", "name": "benzoate catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.\" [GOC:jl, MetaCyc:PWY-7402]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.\" [GOC:jl]" } } }, { "id": "GO:0045022", "name": "early endosome to late endosome transport", "changes": { "definition": { "current": "\"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes.\" [ISBN:0815316194, PMID:29980602]", "previous": "\"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.\" [ISBN:0815316194, PMID:29980602]" } } }, { "id": "GO:0045041", "name": "protein import into mitochondrial intermembrane space", "changes": { "definition": { "current": "\"The import of proteins from the cytosol across the outer mitochondrial membrane into the intermembrane space.\" [ISBN:0716731363]", "previous": "\"The import of proteins into the space between the inner and outer mitochondrial membranes.\" [ISBN:0716731363]" } } }, { "id": "GO:0045136", "name": "development of animal secondary sexual characteristics", "changes": { "name": { "current": "development of animal secondary sexual characteristics", "previous": "development of secondary sexual characteristics" }, "definition": { "current": "\"The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In mammals, examples include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.\" [GOC:ai]", "previous": "\"The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.\" [GOC:ai]" }, "synonyms": { "current": [ "\"development of secondary sexual characteristics\" EXACT []", "\"development of secondary sexual characteristics, sensu Metazoa\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0045337", "name": "trans, trans-farnesyl diphosphate biosynthetic process", "changes": { "name": { "current": "trans, trans-farnesyl diphosphate biosynthetic process", "previous": "farnesyl diphosphate biosynthetic process" }, "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of 2-trans,6-trans-farnesyl diphosphate from prenyl diphosphate.\" [MetaCyc:PWY-5123]", "previous": "\"The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.\" [GOC:jl]" }, "synonyms": { "current": [ "\"farnesyl diphosphate anabolism\" EXACT []", "\"farnesyl diphosphate biosynthesis\" EXACT []", "\"farnesyl diphosphate biosynthetic process\" BROAD []", "\"farnesyl diphosphate formation\" EXACT []", "\"farnesyl diphosphate synthesis\" EXACT []" ], "previous": [ "\"farnesyl diphosphate anabolism\" EXACT []", "\"farnesyl diphosphate biosynthesis\" EXACT []", "\"farnesyl diphosphate formation\" EXACT []", "\"farnesyl diphosphate synthesis\" EXACT []" ] } } }, { "id": "GO:0045490", "name": "pectin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.\" [PMID:11931668, PMID:23079077]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.\" [GOC:curators, PMID:11931668]" } } }, { "id": "GO:0046543", "name": "development of animal secondary female sexual characteristics", "changes": { "name": { "current": "development of animal secondary female sexual characteristics", "previous": "development of secondary female sexual characteristics" }, "definition": { "current": "\"The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female mammals, examples include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.\" [GOC:ai]", "previous": "\"The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.\" [GOC:ai]" }, "synonyms": { "current": [ "\"development of secondary female sexual characteristics\" EXACT []", "\"development of secondary female sexual characteristics, sensu Metazoa\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0046544", "name": "development of animal secondary male sexual characteristics", "changes": { "name": { "current": "development of animal secondary male sexual characteristics", "previous": "development of secondary male sexual characteristics" }, "definition": { "current": "\"The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male mammals, examples include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.\" [GOC:ai]", "previous": "\"The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.\" [GOC:ai]" }, "synonyms": { "current": [ "\"development of secondary male sexual characteristics\" EXACT []", "\"development of secondary male sexual characteristics, sensu Metazoa\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0046951", "name": "ketone body biosynthetic process", "changes": { "synonyms": { "current": [ "\"ketogenesis\" EXACT []", "\"ketone body anabolism\" EXACT []", "\"ketone body biosynthesis\" EXACT []", "\"ketone body formation\" EXACT []", "\"ketone body synthesis\" EXACT []" ], "previous": [ "\"ketone body anabolism\" EXACT []", "\"ketone body biosynthesis\" EXACT []", "\"ketone body formation\" EXACT []", "\"ketone body synthesis\" EXACT []" ] } } }, { "id": "GO:0048208", "name": "COPII vesicle coat assembly", "changes": { "name": { "current": "COPII vesicle coat assembly", "previous": "COPII vesicle coating" }, "synonyms": { "current": [ "\"COPII coating of ER-derived vesicle\" EXACT [GOC:tb]", "\"COPII vesicle coat formation\" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]", "\"COPII vesicle coating\" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]" ], "previous": [ "\"COPII coating of ER-derived vesicle\" EXACT [GOC:tb]", "\"COPII vesicle coat assembly\" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]", "\"COPII vesicle coat formation\" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]" ] } } }, { "id": "GO:0070147", "name": "mitochondrial cysteinyl-tRNA aminoacylation", "changes": { "definition": { "current": "\"The process of coupling L-cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.\" [GOC:mah, GOC:mcc]", "previous": "\"The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.\" [GOC:mah, GOC:mcc]" } } }, { "id": "GO:0071941", "name": "nitrogen cycle metabolic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate", "goslim_chembl", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ], "previous": [ "goslim_chembl", "goslim_generic", "goslim_pombe", "goslim_prokaryote" ] } } }, { "id": "GO:0080145", "name": "intracellular cysteine homeostasis", "changes": { "definition": { "current": "\"A homeostatic process involved in the maintenance of a steady state level of L-cysteine within a cell.\" [PMID:19955263]", "previous": "\"A homeostatic process involved in the maintenance of a steady state level of cysteine within a cell.\" [PMID:19955263]" } } }, { "id": "GO:0097712", "name": "trans-Golgi to periciliary membrane compartment transport", "changes": { "name": { "current": "trans-Golgi to periciliary membrane compartment transport", "previous": "vesicle targeting, trans-Golgi to periciliary membrane compartment" }, "definition": { "current": "\"The directed movement of substances from the trans-Golgi network to the periciliary membrane compartment, the specialized region of the plasma membrane surrounding the base of the cilium including the ciliary pocket, via vesicle-mediated transport.\" [PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645]", "previous": "\"The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.\" [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645]" }, "synonyms": { "current": [ "\"vesicle targeting, trans-Golgi to periciliary membrane compartment\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0140053", "name": "mitochondrial gene expression", "changes": { "definition": { "current": "\"The process of transcribing and translating the mitochondrial genome (mtDNA) to produce at least a subset of oxidative phosphorylation (OXPHOS) proteins, 2 rRNAs, and mitochondrial tRNAs, which are critical for ATP production. Protein maturation is included when required to form an active form of a product from an inactive precursor form.\" [PMID:27058308, PMID:31861673, PMID:38117001]", "previous": "\"The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.\" [PMID:27058308]" } } }, { "id": "GO:0160203", "name": "protein import into the intermembrane space via the disulfide relay system", "changes": { "name": { "current": "protein import into the intermembrane space via the disulfide relay system", "previous": "mitochondrial disulfide relay system" }, "definition": { "current": "\"The import of small cysteine-containing proteins from the cytosol across the outer mitochondrial membrane via the TOM complex driven by oxidative folding.\" [PMID:32936885, PMID:37159021]", "previous": "\"A protein folding process that facilitates the import of a subset of soluble proteins into mitochondrial intermembrane space via disulfide bond formation.\" [PMID:32936885, PMID:37159021]" }, "synonyms": { "current": [ "\"CHCHD4/Mia40-dependent import\" NARROW []", "\"MIA pathway\" EXACT []", "\"mitochondrial disulfide relay system\" EXACT []", "\"mitochondrial intermembrane space assembly pathway\" EXACT []" ], "previous": [ "\"MIA pathway\" EXACT []", "\"mitochondrial intermembrane space assembly pathway\" EXACT []" ] } } }, { "id": "GO:0170038", "name": "proteinogenic amino acid biosynthetic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0170039", "name": "proteinogenic amino acid metabolic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0170040", "name": "proteinogenic amino acid catabolic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0170043", "name": "non-proteinogenic amino acid biosynthetic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:0170044", "name": "non-proteinogenic amino acid catabolic process", "changes": { "subsets": { "current": [ "gocheck_do_not_annotate" ], "previous": "N/A" } } }, { "id": "GO:1901788", "name": "benzoyl-CoA catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA.\" [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA.\" [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739]" } } }, { "id": "GO:1901810", "name": "beta-carotene metabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways involving beta-carotene.\" [GOC:TermGenie, GOC:yaf, PMID:11387982, UniPathway:UPA00802]", "previous": "\"The chemical reactions and pathways involving beta-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]" } } }, { "id": "GO:1901811", "name": "beta-carotene catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of beta-carotene.\" [GOC:TermGenie, GOC:yaf, PMID:11387982, UniPathway:UPA00802]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of beta-carotene.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802]" } } }, { "id": "GO:1901826", "name": "zeaxanthin catabolic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the breakdown of zeaxanthin.\" [GOC:TermGenie, GOC:yaf, UniPathway:UPA00843]", "previous": "\"The chemical reactions and pathways resulting in the breakdown of zeaxanthin.\" [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843]" } } }, { "id": "GO:1901997", "name": "negative regulation of indoleacetic acid biosynthetic process", "changes": { "name": { "current": "negative regulation of indoleacetic acid biosynthetic process", "previous": "negative regulation of indoleacetic acid biosynthetic process via tryptophan" }, "synonyms": { "current": [ "\"down regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid biosynthetic process via tryptophan\" NARROW [GOC:TermGenie]", "\"inhibition of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid biosynthetic process via tryptophan\" NARROW []", "\"negative regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]" ], "previous": [ "\"down regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"down regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"down-regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"downregulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid biosynthetic process via tryptophan\" NARROW [GOC:TermGenie]", "\"inhibition of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"inhibition of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of IAA biosynthetic process via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid anabolism via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid formation via tryptophan\" EXACT [GOC:TermGenie]", "\"negative regulation of indoleacetic acid synthesis via tryptophan\" EXACT [GOC:TermGenie]" ] } } }, { "id": "GO:1902223", "name": "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process", "changes": { "definition": { "current": "\"The chemical reactions and pathways resulting in the formation of an L-amino acid derived from erythrose 4-phosphate and phosphoenolpyruvate (L-phenylalanine, L-tyrosine and L-tryptophan).\" [GOC:curators]", "previous": "\"The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid.\" [GOC:pr, GOC:TermGenie]" } } }, { "id": "GO:1903712", "name": "L-cysteine transmembrane transport", "changes": { "name": { "current": "L-cysteine transmembrane transport", "previous": "cysteine transmembrane transport" }, "definition": { "current": "\"The directed movement of L-cysteine across a membrane.\" [GO_REF:0000069, GOC:TermGenie, PMID:17435223]", "previous": "\"The directed movement of cysteine across a membrane.\" [GO_REF:0000069, GOC:TermGenie, PMID:17435223]" }, "synonyms": { "current": [ "\"cysteine transmembrane transport\" BROAD []" ], "previous": "N/A" } } }, { "id": "GO:1904541", "name": "mating projection tip cell wall disassembly", "changes": { "name": { "current": "mating projection tip cell wall disassembly", "previous": "fungal-type cell wall disassembly involved in conjugation with cellular fusion" }, "definition": { "current": "\"Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion, where the cell wall is locally disassembled to enable conjugation with cellular fusion.\" [GO_REF:0000060, GOC:TermGenie, PMID:25825517]", "previous": "\"Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion.\" [GO_REF:0000060, GOC:TermGenie, PMID:25825517]" }, "synonyms": { "current": [ "\"fungal-type cell wall disassembly involved in cell fusion\" RELATED [GOC:TermGenie]", "\"fungal-type cell wall disassembly involved in conjugation with cellular fusion\" EXACT []", "\"fungal-type cell wall disassembly involved in mating\" RELATED [GOC:TermGenie]" ], "previous": [ "\"fungal-type cell wall disassembly involved in cell fusion\" RELATED [GOC:TermGenie]", "\"fungal-type cell wall disassembly involved in mating\" RELATED [GOC:TermGenie]" ] } } }, { "id": "GO:1990799", "name": "mitochondrial tRNA wobble position uridine thiolation", "changes": { "definition": { "current": "\"The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from L-cysteine to position C2 by several steps.\" [PMID:15509579]", "previous": "\"The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.\" [PMID:15509579]" } } } ], "molecular_function": [ { "id": "GO:0000268", "name": "peroxisome signal sequence receptor activity", "changes": { "name": { "current": "peroxisome signal sequence receptor activity", "previous": "peroxisome targeting sequence binding" }, "definition": { "current": "\"Binding to a peroxisomal targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the peroxisome.\" [PMID:20659419]", "previous": "\"Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome.\" [GOC:mah, ISBN:0879693568]" }, "synonyms": { "current": [ "\"peroxisome targeting sequence binding\" NARROW []", "\"peroxisome targeting signal receptor\" NARROW []", "\"PTS binding\" EXACT []", "\"PTS receptor\" NARROW []" ], "previous": [ "\"peroxisome targeting signal receptor\" NARROW []", "\"PTS binding\" EXACT []", "\"PTS receptor\" NARROW []" ] } } }, { "id": "GO:0003875", "name": "ADP-ribosylarginine-[protein] hydrolase activity", "changes": { "name": { "current": "ADP-ribosylarginine-[protein] hydrolase activity", "previous": "ADP-ribosylarginine hydrolase activity" }, "synonyms": { "current": [ "\"ADP-ribose-L-arginine cleavage enzyme activity\" RELATED [EC:3.2.2.19]", "\"ADP-ribose-L-arginine cleaving enzyme activity\" RELATED [EC:3.2.2.19]", "\"ADP-ribosylarginine hydrolase activity\" EXACT []", "\"ADPribosylarginine hydrolase activity\" EXACT []", "\"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"protein ADP-ribosylarginine hydrolase activity\" RELATED [EC:3.2.2.19]", "\"protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]" ], "previous": [ "\"ADP-ribose-L-arginine cleavage enzyme activity\" RELATED [EC:3.2.2.19]", "\"ADP-ribose-L-arginine cleaving enzyme activity\" RELATED [EC:3.2.2.19]", "\"ADPribosylarginine hydrolase activity\" EXACT []", "\"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]", "\"protein ADP-ribosylarginine hydrolase activity\" RELATED [EC:3.2.2.19]", "\"protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity\" RELATED [EC:3.2.2.19]" ] } } }, { "id": "GO:0004729", "name": "protoporphyrinogen oxidase activity, oxygen as acceptor", "changes": { "name": { "current": "protoporphyrinogen oxidase activity, oxygen as acceptor", "previous": "oxygen-dependent protoporphyrinogen oxidase activity" }, "synonyms": { "current": [ "\"oxygen-dependent protoporphyrinogen oxidase activity\" EXACT []", "\"protoporphyrinogen-IX:oxygen oxidoreductase activity\" RELATED [EC:1.3.3.4]" ], "previous": [ "\"protoporphyrinogen-IX:oxygen oxidoreductase activity\" RELATED [EC:1.3.3.4]" ] } } }, { "id": "GO:0005048", "name": "signal sequence receptor activity", "changes": { "name": { "current": "signal sequence receptor activity", "previous": "signal sequence binding" }, "definition": { "current": "\"Binding to a signal sequence, a short stretch of amino acids found in a protein that acts as a signal for its proper localization in the cell.\" [GOC:curators]", "previous": "\"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.\" [GOC:ai]" }, "synonyms": { "current": [ "\"leader sequence binding\" NARROW []", "\"protein signal sequence binding\" NARROW []", "\"signal sequence binding\" NARROW []", "\"signal sequence receptor\" NARROW []" ], "previous": [ "\"leader sequence binding\" NARROW []", "\"protein signal sequence binding\" NARROW []", "\"signal sequence receptor\" NARROW []" ] } } }, { "id": "GO:0008093", "name": "cytoskeletal adaptor activity", "changes": { "name": { "current": "cytoskeletal adaptor activity", "previous": "cytoskeletal anchor activity" }, "synonyms": { "current": [ "\"cytoskeletal anchor activity\" NARROW []" ], "previous": [ "\"cytoskeletal adaptor activity\" EXACT []" ] } } }, { "id": "GO:0008253", "name": "5'-nucleotidase activity", "changes": { "synonyms": { "current": [ "\"5' nucleotidase activity\" EXACT []", "\"5'-adenylic phosphatase\" NARROW [EC:3.1.3.5]", "\"5'-AMP nucleotidase\" NARROW [EC:3.1.3.5]", "\"5'-AMPase\" NARROW [EC:3.1.3.5]", "\"5'-mononucleotidase activity\" RELATED [EC:3.1.3.5]", "\"5'-ribonucleotide phosphohydrolase activity\" NARROW [EC:3.1.3.5]", "\"adenosine 5'-phosphatase\" NARROW [EC:3.1.3.5]", "\"adenosine monophosphatase\" NARROW [EC:3.1.3.5]", "\"AMP phosphatase\" NARROW [EC:3.1.3.5]", "\"AMP phosphohydrolase\" NARROW [EC:3.1.3.5]", "\"AMPase\" NARROW [EC:3.1.3.5]", "\"snake venom 5'-nucleotidase\" NARROW [EC:3.1.3.5]", "\"thimidine monophosphate nucleotidase\" NARROW [EC:3.1.3.5]", "\"UMPase\" NARROW [EC:3.1.3.5]", "\"uridine 5'-nucleotidase\" NARROW [EC:3.1.3.5]" ], "previous": [ "\"5' nucleotidase activity\" EXACT []", "\"5'-adenylic phosphatase\" NARROW [EC:3.1.3.5]", "\"5'-AMP nucleotidase\" NARROW [EC:3.1.3.5]", "\"5'-AMPase\" NARROW [EC:3.1.3.5]", "\"5'-mononucleotidase activity\" RELATED [EC:3.1.3.5]", "\"5'-ribonucleotide phosphohydrolase activity\" RELATED [EC:3.1.3.5]", "\"adenosine 5'-phosphatase\" NARROW [EC:3.1.3.5]", "\"adenosine monophosphatase\" NARROW [EC:3.1.3.5]", "\"AMP phosphatase\" NARROW [EC:3.1.3.5]", "\"AMP phosphohydrolase\" NARROW [EC:3.1.3.5]", "\"AMPase\" NARROW [EC:3.1.3.5]", "\"snake venom 5'-nucleotidase\" NARROW [EC:3.1.3.5]", "\"thimidine monophosphate nucleotidase\" NARROW [EC:3.1.3.5]", "\"UMPase\" NARROW [EC:3.1.3.5]", "\"uridine 5'-nucleotidase\" NARROW [EC:3.1.3.5]" ] } } }, { "id": "GO:0008805", "name": "aerobic carbon monoxide dehydrogenase activity", "changes": { "name": { "current": "aerobic carbon monoxide dehydrogenase activity", "previous": "carbon-monoxide oxygenase activity" }, "synonyms": { "current": [ "\"carbon monoxide oxidase activity\" RELATED []", "\"carbon monoxide oxygenase (cytochrome b-561) activity\" NARROW []", "\"carbon monoxide oxygenase activity\" EXACT []", "\"carbon monoxide,water:cytochrome b-561 oxidoreductase activity\" RELATED []", "\"carbon monoxide:methylene blue oxidoreductase activity\" NARROW []", "\"carbon-monoxide dehydrogenase (cytochrome b-561)\" RELATED []", "\"carbon-monoxide oxygenase activity\" BROAD []", "\"cytochrome b561\" NARROW []" ], "previous": [ "\"carbon monoxide oxidase activity\" RELATED []", "\"carbon monoxide oxygenase (cytochrome b-561) activity\" NARROW []", "\"carbon monoxide oxygenase activity\" EXACT []", "\"carbon monoxide,water:cytochrome b-561 oxidoreductase activity\" RELATED []", "\"carbon monoxide:methylene blue oxidoreductase activity\" NARROW []", "\"carbon-monoxide dehydrogenase (cytochrome b-561)\" RELATED []", "\"cytochrome b561\" NARROW []" ] } } }, { "id": "GO:0008873", "name": "gluconate 2-dehydrogenase (NADP+) activity", "changes": { "name": { "current": "gluconate 2-dehydrogenase (NADP+) activity", "previous": "gluconate 2-dehydrogenase activity" }, "synonyms": { "current": [ "\"2-keto-D-gluconate reductase activity\" RELATED [EC:1.1.1.215]", "\"2-ketogluconate reductase activity\" RELATED [EC:1.1.1.215]", "\"gluconate 2-dehydrogenase activity\" BROAD []" ], "previous": [ "\"2-keto-D-gluconate reductase activity\" RELATED [EC:1.1.1.215]", "\"2-ketogluconate reductase activity\" RELATED [EC:1.1.1.215]" ] } } }, { "id": "GO:0008874", "name": "gluconate 5-dehydrogenase [NAD(P)+] activity", "changes": { "name": { "current": "gluconate 5-dehydrogenase [NAD(P)+] activity", "previous": "gluconate 5-dehydrogenase activity" }, "synonyms": { "current": [ "\"5-keto-D-gluconate 5-reductase activity\" RELATED [EC:1.1.1.69]", "\"5-keto-D-gluconate reductase\" RELATED [EC:1.1.1.69]", "\"5-ketogluconate 5-reductase activity\" RELATED [EC:1.1.1.69]", "\"5-ketogluconate reductase activity\" RELATED [EC:1.1.1.69]", "\"D-gluconate:NAD(P)+ 5-oxidoreductase\" RELATED [EC:1.1.1.69]", "\"gluconate 5-dehydrogenase activity\" EXACT []" ], "previous": [ "\"5-keto-D-gluconate 5-reductase activity\" RELATED [EC:1.1.1.69]", "\"5-keto-D-gluconate reductase\" RELATED [EC:1.1.1.69]", "\"5-ketogluconate 5-reductase activity\" RELATED [EC:1.1.1.69]", "\"5-ketogluconate reductase activity\" RELATED [EC:1.1.1.69]", "\"D-gluconate:NAD(P)+ 5-oxidoreductase\" RELATED [EC:1.1.1.69]" ] } } }, { "id": "GO:0008941", "name": "nitric oxide dioxygenase [NAD(P)H] activity", "changes": { "name": { "current": "nitric oxide dioxygenase [NAD(P)H] activity", "previous": "nitric oxide dioxygenase NAD(P)H activity" } } }, { "id": "GO:0030343", "name": "vitamin D 25-hydroxylase activity", "changes": { "name": { "current": "vitamin D 25-hydroxylase activity", "previous": "vitamin D3 25-hydroxylase activity" }, "synonyms": { "current": [ "\"cholecalciferol 25-hydroxylase activity\" EXACT []", "\"vitamin D3 25-hydroxylase activity\" EXACT []" ], "previous": [ "\"cholecalciferol 25-hydroxylase activity\" EXACT []" ] } } }, { "id": "GO:0030674", "name": "protein-macromolecule adaptor activity", "changes": { "comment": { "current": "Note that protein complex scaffolds should use GO:0140378 protein complex scaffold activity.", "previous": "N/A" }, "synonyms": { "current": [ "\"protein binding, bridging\" EXACT []", "\"protein recruiting activity\" RELATED []", "\"protein-protein adaptor\" NARROW []" ], "previous": [ "\"protein binding, bridging\" EXACT []", "\"protein complex scaffold activity\" BROAD []", "\"protein recruiting activity\" RELATED []", "\"protein-containing complex scaffold activity\" BROAD []", "\"protein-protein adaptor\" NARROW []" ] } } }, { "id": "GO:0030941", "name": "chloroplast targeting sequence receptor activity", "changes": { "name": { "current": "chloroplast targeting sequence receptor activity", "previous": "chloroplast targeting sequence binding" }, "definition": { "current": "\"Binding to a chloroplast targeting sequence, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the chloroplast.\" [PMID:35929083]", "previous": "\"Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.\" [GOC:mah]" }, "synonyms": { "current": [ "\"chloroplast targeting sequence binding\" NARROW []" ], "previous": "N/A" } } }, { "id": "GO:0030942", "name": "endoplasmic reticulum signal sequence receptor activity", "changes": { "name": { "current": "endoplasmic reticulum signal sequence receptor activity", "previous": "endoplasmic reticulum signal peptide binding" }, "definition": { "current": "\"Binding to an endoplasmic reticulum signal peptide, a short stretch of amino acids found in a protein that acts as a signal to localize the protein to the endoplasmic reticulum.\" [GOC:mah]", "previous": "\"Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.\" [GOC:mah]" }, "synonyms": { "current": [ "\"endoplasmic reticulum signal peptide binding\" NARROW []", "\"ER signal peptide binding\" EXACT []" ], "previous": [ "\"ER signal peptide binding\" EXACT []" ] } } }, { "id": "GO:0033229", "name": "L-cysteine transmembrane transporter activity", "changes": { "name": { "current": "L-cysteine transmembrane transporter activity", "previous": "cysteine transmembrane transporter activity" }, "definition": { "current": "\"Enables the transfer of L-cysteine from one side of a membrane to the other.\" [GOC:mah]", "previous": "\"Enables the transfer of cysteine from one side of a membrane to the other.\" [GOC:mah]" }, "synonyms": { "current": [ "\"cysteine transmembrane transporter activity\" BROAD []" ], "previous": "N/A" } } }, { "id": "GO:0033230", "name": "ABC-type L-cysteine transporter activity", "changes": { "name": { "current": "ABC-type L-cysteine transporter activity", "previous": "ABC-type cysteine transporter activity" }, "synonyms": { "current": [ "\"ABC-type cysteine transporter activity\" BROAD []", "\"ATP-dependent cysteine transporter activity\" BROAD []", "\"ATPase-coupled cysteine transmembrane transporter activity\" RELATED []", "\"ATPase-coupled cysteine transporter activity\" RELATED []", "\"cysteine exporter\" RELATED []", "\"cysteine-exporting ATPase activity\" RELATED []", "\"cysteine-transporting ATPase activity\" BROAD []" ], "previous": [ "\"ATP-dependent cysteine transporter activity\" EXACT []", "\"ATPase-coupled cysteine transmembrane transporter activity\" RELATED []", "\"ATPase-coupled cysteine transporter activity\" RELATED []", "\"cysteine exporter\" RELATED []", "\"cysteine-exporting ATPase activity\" RELATED []", "\"cysteine-transporting ATPase activity\" EXACT []" ] } } }, { "id": "GO:0039630", "name": "RNA translocase activity", "changes": { "comment": { "current": "N/A", "previous": "Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane." } } }, { "id": "GO:0043712", "name": "(R)-2-hydroxy-4-methylpentanoate CoA-transferase activity", "changes": { "name": { "current": "(R)-2-hydroxy-4-methylpentanoate CoA-transferase activity", "previous": "2-hydroxyisocaproate CoA-transferase activity" }, "synonyms": { "current": [ "\"(R)-2-hydroxyisocaproate CoA transferase activity\" EXACT []", "\"2-hydroxyisocaproate CoA-transferase activity\" EXACT []", "\"https://github.com/geneontology/go-ontology/issues/31862\" EXACT []" ], "previous": [ "\"(R)-2-hydroxyisocaproate CoA transferase activity\" EXACT []", "\"(R)-2-hydroxyisocaproate CoA-transferase activity\" EXACT []" ] } } }, { "id": "GO:0046923", "name": "ER lumen protein retrieval receptor activity", "changes": { "name": { "current": "ER lumen protein retrieval receptor activity", "previous": "ER retention sequence binding" }, "definition": { "current": "\"Binding to an endoplasmic reticulum (ER) retention sequence, a short stretch of amino acids found in a protein that acts as a signal to retain the protein within the ER.\" [GOC:ai]", "previous": "\"Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.\" [GOC:ai]" }, "synonyms": { "current": [ "\"endoplasmic reticulum retention sequence binding\" EXACT []", "\"ER retention sequence binding\" NARROW []" ], "previous": [ "\"endoplasmic reticulum retention sequence binding\" EXACT []" ] } } }, { "id": "GO:0047074", "name": "hydroxyquinol 1,2-dioxygenase activity", "changes": { "name": { "current": "hydroxyquinol 1,2-dioxygenase activity", "previous": "4-hydroxycatechol 1,2-dioxygenase activity" }, "synonyms": { "current": [ "\"4-hydroxycatechol 1,2-dioxygenase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0047081", "name": "3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity", "changes": { "name": { "current": "3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity", "previous": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity" }, "synonyms": { "current": [ "\"2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)\" RELATED [EC:1.14.13.242]", "\"3-hydroxy-2-methylpyridinecarboxylate dioxygenase [NAD(P)H] activity\" RELATED []", "\"3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"methylhydroxypyridine carboxylate dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"methylhydroxypyridinecarboxylate oxidase activity\" RELATED [EC:1.14.13.242]" ], "previous": [ "\"2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)\" RELATED [EC:1.14.13.242]", "\"3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"methylhydroxypyridine carboxylate dioxygenase activity\" RELATED [EC:1.14.13.242]", "\"methylhydroxypyridinecarboxylate oxidase activity\" RELATED [EC:1.14.13.242]" ] } } }, { "id": "GO:0050067", "name": "L-lysine 2-monooxygenase activity", "changes": { "name": { "current": "L-lysine 2-monooxygenase activity", "previous": "lysine 2-monooxygenase activity" }, "synonyms": { "current": [ "\"L-lysine-2-monooxygenase activity\" RELATED [EC:1.13.12.2]", "\"L-lysine:oxygen 2-oxidoreductase (decarboxylating)\" RELATED [EC:1.13.12.2]", "\"lysine 2-monooxygenase activity\" EXACT []", "\"lysine monooxygenase activity\" RELATED [EC:1.13.12.2]", "\"lysine oxygenase activity\" RELATED [EC:1.13.12.2]" ], "previous": [ "\"L-lysine-2-monooxygenase activity\" RELATED [EC:1.13.12.2]", "\"L-lysine:oxygen 2-oxidoreductase (decarboxylating)\" RELATED [EC:1.13.12.2]", "\"lysine monooxygenase activity\" RELATED [EC:1.13.12.2]", "\"lysine oxygenase activity\" RELATED [EC:1.13.12.2]" ] } } }, { "id": "GO:0050607", "name": "S-(hydroxymethyl)mycothiol dehydrogenase activity", "changes": { "name": { "current": "S-(hydroxymethyl)mycothiol dehydrogenase activity", "previous": "mycothiol-dependent formaldehyde dehydrogenase activity" }, "synonyms": { "current": [ "\"formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)\" EXACT []", "\"mycothiol-dependent formaldehyde dehydrogenase activity\" EXACT []", "\"NAD/factor-dependent formaldehyde dehydrogenase activity\" RELATED [EC:1.1.1.306]" ], "previous": [ "\"formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)\" EXACT []", "\"NAD/factor-dependent formaldehyde dehydrogenase activity\" RELATED [EC:1.1.1.306]" ] } } }, { "id": "GO:0070007", "name": "glutamic-type endopeptidase activity", "changes": { "is_obsolete": { "current": false, "previous": true }, "name": { "current": "glutamic-type endopeptidase activity", "previous": "obsolete glutamic-type endopeptidase activity" }, "definition": { "current": "\"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.\" [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]", "previous": "\"OBSOLETE. Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.\" [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]" }, "comment": { "current": "Unobsoleted, since similar terms exist.", "previous": "This term was obsoleted because it represents a specific substrate." } } }, { "id": "GO:0070819", "name": "protoporphyrinogen oxidase activity, quinone as acceptor", "changes": { "name": { "current": "protoporphyrinogen oxidase activity, quinone as acceptor", "previous": "menaquinone-dependent protoporphyrinogen oxidase activity" }, "synonyms": { "current": [ "\"menaquinone-dependent protoporphyrinogen oxidase activity\" NARROW []", "\"protoporphyrinogen-IX:menaquinone oxidoreductase activity\" NARROW [GOC:mah]", "\"quinone-dependent protoporphyrinogen oxidase activity\" EXACT []" ], "previous": [ "\"protoporphyrinogen-IX:menaquinone oxidoreductase activity\" EXACT [GOC:mah]" ] } } }, { "id": "GO:0102157", "name": "sulfopropanediol 3-dehydrogenase activity", "changes": { "name": { "current": "sulfopropanediol 3-dehydrogenase activity", "previous": "(R)-sulfopropanediol 2-dehydrogenase activity" } } }, { "id": "GO:0102177", "name": "4alpha-monomethylsterol monooxygenase activity", "changes": { "name": { "current": "4alpha-monomethylsterol monooxygenase activity", "previous": "24-methylenelophenol methyl oxidase activity" }, "synonyms": { "current": [ "\"24-methylenelophenol methyl oxidase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0102394", "name": "L-isoleucine 4-hydroxylase activity", "changes": { "name": { "current": "L-isoleucine 4-hydroxylase activity", "previous": "4-hydroxy-L-isoleucine dehydrogenase activity" }, "synonyms": { "current": [ "\"4-hydroxy-L-isoleucine dehydrogenase activity\" RELATED []" ], "previous": "N/A" } } }, { "id": "GO:0106145", "name": "scopoletin 8-hydroxylase activity", "changes": { "definition": { "current": "\"Catalysis of the reaction", "previous": "\"Catalyzes of the reaction" } } }, { "id": "GO:0140177", "name": "membrane-membrane adaptor activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex, vesicle or organelle.\" [GOC:curators]", "previous": "\"The binding activity of a molecule that brings together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.\" [GOC:curators]" } } }, { "id": "GO:0140292", "name": "ADP-ribosylserine-[protein] hydrolase activity", "changes": { "name": { "current": "ADP-ribosylserine-[protein] hydrolase activity", "previous": "ADP-ribosylserine hydrolase activity" }, "synonyms": { "current": [ "\"ADP-ribosylserine hydrolase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0140293", "name": "ADP-ribosylglutamate-[protein] hydrolase activity", "changes": { "name": { "current": "ADP-ribosylglutamate-[protein] hydrolase activity", "previous": "ADP-ribosylglutamate hydrolase activity" }, "synonyms": { "current": [ "\"ADP-ribosylglutamate hydrolase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0140443", "name": "mitochondrion-plasma membrane adaptor activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together a mitochondrial outer membrane and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.\" [PMID:31582398]", "previous": "\"The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.\" [PMID:31582398]" } } }, { "id": "GO:0140474", "name": "mitochondrion-endoplasmic reticulum membrane tether activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together a mitochondrial outer membrane and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.\" [PMID:19556461, PMID:27875684]", "previous": "\"The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.\" [PMID:19556461, PMID:27875684]" } } }, { "id": "GO:0140506", "name": "endoplasmic reticulum-autophagosome adaptor activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together an ER membrane and an autophagosome membrane during reticulophagy.\" [PMID:32735772]", "previous": "\"The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.\" [PMID:32735772]" } } }, { "id": "GO:0140580", "name": "mitochondrion autophagosome adaptor activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome membrane during mitophagy.\" [PMID:33138913]", "previous": "\"The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy.\" [PMID:33138913]" } } }, { "id": "GO:0140597", "name": "protein carrier activity", "changes": { "definition": { "current": "\"Directly binding to a protein and delivering it either to an acceptor molecule or to a specific location.\" [PMID:7628437]", "previous": "\"Binding to and carrying a protein to an acceptor molecule or to a specific location by moving along with the target protein.\" [PMID:7628437]" } } }, { "id": "GO:0140740", "name": "ADP-riboxanase-[protein] activity", "changes": { "name": { "current": "ADP-riboxanase-[protein] activity", "previous": "ADP-riboxanase activity" }, "synonyms": { "current": [ "\"ADP-riboxanase activity\" EXACT []" ], "previous": "N/A" } } }, { "id": "GO:0160183", "name": "autophagosome-membrane adaptor activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together a target membrane and an autophagosome membrane during autophagy.\" [PMID:30544615, PMID:36635405]", "previous": "\"The binding activity of a molecule that brings together a target membrane and an autophagosome during autophagy.\" [PMID:30544615, PMID:36635405]" } } }, { "id": "GO:0160190", "name": "peroxisome-mitochondrion membrane tether activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together the peroxisome membrane and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.\" [PMID:29720625, PMID:38669296]", "previous": "\"The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.\" [PMID:29720625, PMID:38669296]" } } }, { "id": "GO:0160229", "name": "peroxisome-endoplasmic reticulum membrane tether activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together a peroxisome membrane and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.\" [PMID:39271061]", "previous": "\"The binding activity of a molecule that brings together a peroxisome and an ER membrane, either via membrane lipid binding or by interacting with a membrane protein.\" [PMID:39271061]" } } }, { "id": "GO:0170016", "name": "endoplasmic reticulum-endosome tether activity", "changes": { "definition": { "current": "\"The binding activity of a molecule that brings together an endosome membrane and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.\" [PMID:33124732]", "previous": "\"The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.\" [PMID:33124732]" } } } ] }, "cross_references": { "biological_process": [ { "id": "GO:0000103", "name": "sulfate assimilation", "changes": { "xrefs": { "current": [ "MetaCyc:SO4ASSIM-PWY", "MetaCyc:SULFMETII-PWY" ], "previous": "N/A" } } }, { "id": "GO:0000256", "name": "allantoin catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:ALLANTOINDEG-PWY", "MetaCyc:PWY0-41" ], "previous": "N/A" } } }, { "id": "GO:0002353", "name": "plasma kallikrein-kinin cascade", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9970672 \"FXIIa activates plasma kallikrein-kinin system\"" ], "previous": "N/A" } } }, { "id": "GO:0002862", "name": "negative regulation of inflammatory response to antigenic stimulus", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9662851 \"Anti-inflammatory response favouring Leishmania parasite infection\"" ], "previous": [ "Reactome:R-HSA-9660821 \"ADORA2B mediated anti-inflammatory cytokines production\"", "Reactome:R-HSA-9662834 \"CD163 mediating an anti-inflammatory response\"", "Reactome:R-HSA-9664323 \"FCGR3A-mediated IL10 synthesis\"", "Reactome:R-HSA-9664535 \"LTC4-CYSLTR mediated IL4 production\"" ] } } }, { "id": "GO:0005978", "name": "glycogen biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCOGENSYNTH-PWY", "MetaCyc:PWY-5067", "MetaCyc:PWY-7900", "Reactome:R-HSA-3322077 \"Glycogen synthesis\"" ], "previous": [ "MetaCyc:PWY-7900", "Reactome:R-HSA-3322077 \"Glycogen synthesis\"" ] } } }, { "id": "GO:0005980", "name": "glycogen catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCOCAT-PWY", "MetaCyc:PWY-5941", "MetaCyc:PWY-7662", "Reactome:R-HSA-70221 \"Glycogen breakdown (glycogenolysis)\"" ], "previous": [ "MetaCyc:PWY-7662", "Reactome:R-HSA-70221 \"Glycogen breakdown (glycogenolysis)\"" ] } } }, { "id": "GO:0005987", "name": "sucrose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-621", "MetaCyc:SUCUTIL-PWY" ], "previous": "N/A" } } }, { "id": "GO:0005990", "name": "lactose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:BGALACT-PWY", "MetaCyc:LACTOSECAT-PWY", "MetaCyc:LACTOSEUTIL-PWY" ], "previous": [ "MetaCyc:BGALACT-PWY" ] } } }, { "id": "GO:0006096", "name": "glycolytic process", "changes": { "xrefs": { "current": [ "MetaCyc:GLYCOLYSIS-VARIANTS", "MetaCyc:P341-PWY" ], "previous": [ "MetaCyc:GLYCOLYSIS-VARIANTS" ] } } }, { "id": "GO:0006479", "name": "protein methylation", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-8876725 \"Protein methylation\"" ] } } }, { "id": "GO:0006525", "name": "arginine metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "Wikipedia:Arginine" ] } } }, { "id": "GO:0006536", "name": "glutamate metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "Wikipedia:Glutamic_acid" ] } } }, { "id": "GO:0006555", "name": "L-methionine metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "UM-BBD_pathwayID:met" ] } } }, { "id": "GO:0006563", "name": "L-serine metabolic process", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-977347 \"Serine metabolism\"" ] } } }, { "id": "GO:0006567", "name": "L-threonine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5436", "MetaCyc:PWY-5437", "MetaCyc:PWY66-428", "MetaCyc:THRDLCTCAT-PWY", "MetaCyc:THREONINE-DEG2-PWY", "Reactome:R-HSA-8849175 \"Threonine catabolism\"", "UM-BBD_pathwayID:met" ], "previous": [ "MetaCyc:PWY-5436", "MetaCyc:PWY-5437", "MetaCyc:PWY66-428", "MetaCyc:THRDLCTCAT-PWY", "MetaCyc:THREONINE-DEG2-PWY", "UM-BBD_pathwayID:met" ] } } }, { "id": "GO:0006572", "name": "L-tyrosine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5151", "MetaCyc:PWY-7514", "MetaCyc:PWY-8016", "MetaCyc:PWY3O-4108", "MetaCyc:TYRFUMCAT-PWY", "Reactome:R-HSA-8963684 \"Tyrosine catabolism\"", "UM-BBD_pathwayID:tyr" ], "previous": [ "MetaCyc:PWY-5151", "MetaCyc:PWY-7514", "MetaCyc:PWY-8016", "MetaCyc:PWY3O-4108", "MetaCyc:TYRFUMCAT-PWY", "Reactome:R-HSA-8963684 \"Tyrosine catabolism\"" ] } } }, { "id": "GO:0006596", "name": "polyamine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:POLYAMINSYN3-PWY", "MetaCyc:POLYAMSYN-PWY", "Reactome:R-HSA-350562 \"Regulation of ornithine decarboxylase (ODC)\"", "Reactome:R-HSA-351200 \"Interconversion of polyamines\"" ], "previous": [ "MetaCyc:POLYAMINSYN3-PWY", "MetaCyc:POLYAMSYN-PWY", "Reactome:R-HSA-351200 \"Interconversion of polyamines\"" ] } } }, { "id": "GO:0006602", "name": "creatinine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:CRNFORCAT-PWY", "MetaCyc:PWY-4722", "MetaCyc:PWY-4741" ], "previous": "N/A" } } }, { "id": "GO:0006635", "name": "fatty acid beta-oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5137", "MetaCyc:PWY-5138", "Reactome:R-HSA-77289 \"Mitochondrial Fatty Acid Beta-Oxidation\"" ], "previous": [ "Reactome:R-HSA-77289 \"Mitochondrial Fatty Acid Beta-Oxidation\"" ] } } }, { "id": "GO:0006656", "name": "phosphatidylcholine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6825", "MetaCyc:PWY-6826", "MetaCyc:PWY-7470", "MetaCyc:PWY4FS-2", "MetaCyc:PWY4FS-3", "MetaCyc:PWY4FS-4", "Reactome:R-HSA-1483191 \"Synthesis of PC\"" ], "previous": [ "Reactome:R-HSA-1483191 \"Synthesis of PC\"" ] } } }, { "id": "GO:0006695", "name": "cholesterol biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY66-3", "MetaCyc:PWY66-341", "MetaCyc:PWY66-4", "Reactome:R-HSA-191273 \"Cholesterol biosynthesis\"" ], "previous": [ "Reactome:R-HSA-191273 \"Cholesterol biosynthesis\"" ] } } }, { "id": "GO:0006780", "name": "uroporphyrinogen III biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5188", "MetaCyc:PWY-5189" ], "previous": "N/A" } } }, { "id": "GO:0007597", "name": "blood coagulation, intrinsic pathway", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-140837 \"Intrinsic Pathway of Fibrin Clot Formation\"" ] } } }, { "id": "GO:0007598", "name": "blood coagulation, extrinsic pathway", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-140834 \"Extrinsic Pathway of Fibrin Clot Formation\"" ] } } }, { "id": "GO:0009236", "name": "cobalamin biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:P381-PWY", "MetaCyc:PWY-5507" ], "previous": "N/A" } } }, { "id": "GO:0009298", "name": "GDP-mannose biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5659 {status=\"skos:exactMatch\"}", "Reactome:R-HSA-446205 \"Synthesis of GDP-mannose\"" ], "previous": [ "Reactome:R-HSA-446205 \"Synthesis of GDP-mannose\"" ] } } }, { "id": "GO:0009446", "name": "putrescine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-40", "MetaCyc:PWY-43", "MetaCyc:PWY-46" ], "previous": "N/A" } } }, { "id": "GO:0009447", "name": "putrescine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PUTDEG-PWY", "MetaCyc:PWY-0", "MetaCyc:PWY-2", "MetaCyc:PWY-3", "MetaCyc:PWY0-1221" ], "previous": "N/A" } } }, { "id": "GO:0009450", "name": "GABA catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:4AMINOBUTMETAB-PWY", "MetaCyc:PWY-5022", "MetaCyc:PWY-6473", "MetaCyc:PWY-6535", "MetaCyc:PWY-6536", "MetaCyc:PWY-6537", "Reactome:R-HSA-916853 \"Degradation of GABA\"" ], "previous": [ "MetaCyc:PWY-5022", "MetaCyc:PWY-6473", "MetaCyc:PWY-6535", "MetaCyc:PWY-6536", "MetaCyc:PWY-6537", "Reactome:R-HSA-916853 \"Degradation of GABA\"" ] } } }, { "id": "GO:0009684", "name": "indoleacetic acid biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-3161", "MetaCyc:PWY-5025", "MetaCyc:PWY-5026", "MetaCyc:PWY-581", "MetaCyc:PWY-6303", "MetaCyc:PWYDQC-4", "MetaCyc:TRPIAACAT-PWY" ], "previous": "N/A" } } }, { "id": "GO:0010264", "name": "myo-inositol hexakisphosphate biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-4661", "MetaCyc:PWY-6362", "MetaCyc:PWY-6372", "MetaCyc:PWY-6554", "MetaCyc:PWY-6555" ], "previous": "N/A" } } }, { "id": "GO:0016260", "name": "L-selenocysteine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6281", "MetaCyc:PWY0-901", "Reactome:R-HSA-2408557 \"Selenocysteine synthesis\"" ], "previous": [ "MetaCyc:PWY-6281", "MetaCyc:PWY0-901" ] } } }, { "id": "GO:0019244", "name": "pyruvate fermentation to lactate", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5481", "MetaCyc:PWY-8274" ], "previous": "N/A" } } }, { "id": "GO:0019254", "name": "carnitine metabolic process, CoA-linked", "changes": { "xrefs": { "current": "N/A", "previous": [ "MetaCyc:CARNMET-PWY" ] } } }, { "id": "GO:0019329", "name": "ammonia oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-2242" ], "previous": "N/A" } } }, { "id": "GO:0019381", "name": "atrazine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:P141-PWY", "MetaCyc:PWY-5724", "UM-BBD_pathwayID:atr" ], "previous": [ "MetaCyc:PWY-5724", "UM-BBD_pathwayID:atr" ] } } }, { "id": "GO:0019396", "name": "gallate catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:GALLATE-DEGRADATION-I-PWY", "MetaCyc:GALLATE-DEGRADATION-II-PWY", "MetaCyc:P3-PWY", "UM-BBD_pathwayID:gal" ], "previous": [ "UM-BBD_pathwayID:gal" ] } } }, { "id": "GO:0019417", "name": "sulfur oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:FESULFOX-PWY", "MetaCyc:PWY-5294", "MetaCyc:PWY-5304", "MetaCyc:SULFUROX-PWY" ], "previous": "N/A" } } }, { "id": "GO:0019418", "name": "sulfide oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:P222-PWY", "MetaCyc:PWY-5274", "MetaCyc:PWY-5285", "MetaCyc:PWY-7927" ], "previous": [ "MetaCyc:Sulfide-Oxidation" ] } } }, { "id": "GO:0019571", "name": "D-arabinose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:DARABCAT-PWY" ], "previous": "N/A" } } }, { "id": "GO:0019572", "name": "L-arabinose catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:ARABCAT-PWY {status=\"skos:narrowMatch\"}" ], "previous": "N/A" } } }, { "id": "GO:0019596", "name": "(R)-mandelate catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-1501", "MetaCyc:PWY-6957" ], "previous": "N/A" } } }, { "id": "GO:0019600", "name": "toluene oxidation", "changes": { "xrefs": { "current": [ "MetaCyc:TOLUENE-DEG-2-OH-PWY", "MetaCyc:TOLUENE-DEG-3-OH-PWY", "MetaCyc:TOLUENE-DEG-4-OH-PWY", "MetaCyc:TOLUENE-DEG-CATECHOL-PWY", "MetaCyc:TOLUENE-DEG-DIOL-PWY" ], "previous": "N/A" } } }, { "id": "GO:0019649", "name": "formaldehyde assimilation", "changes": { "xrefs": { "current": [ "MetaCyc:P185-PWY", "MetaCyc:PWY-1861" ], "previous": "N/A" } } }, { "id": "GO:0019761", "name": "glucosinolate biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-1187", "MetaCyc:PWY-2821" ], "previous": "N/A" } } }, { "id": "GO:0019853", "name": "L-ascorbic acid biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-882" ], "previous": "N/A" } } }, { "id": "GO:0030645", "name": "acetyl-CoA fermentation to butanoate", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5676" ], "previous": [ "Metacyc:PWY-5676" ] } } }, { "id": "GO:0031456", "name": "glycine betaine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:BETSYN-PWY", "MetaCyc:P541-PWY", "MetaCyc:PWY-3722", "MetaCyc:PWY1F-353" ], "previous": "N/A" } } }, { "id": "GO:0033305", "name": "chlorophyll a biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5064", "MetaCyc:PWY-5086" ], "previous": "N/A" } } }, { "id": "GO:0033536", "name": "ajugose biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5342", "MetaCyc:PWY-5343" ], "previous": "N/A" } } }, { "id": "GO:0042216", "name": "phenanthrene catabolic process", "changes": { "xrefs": { "current": [ "UM-BBD_pathwayID:pha2", "UM-BBD_pathwayID:pha3", "UM-BBD_pathwayID:phe" ], "previous": [ "UM-BBD_pathwayID:phe" ] } } }, { "id": "GO:0042413", "name": "carnitine catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:", "MetaCyc:CARNMET-PWY", "MetaCyc:PWY-3602", "MetaCyc:PWY-3641", "MetaCyc:PWY-8307" ], "previous": "N/A" } } }, { "id": "GO:0042425", "name": "choline biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-3385", "MetaCyc:PWY-3542", "MetaCyc:PWY-3561", "MetaCyc:PWY-4762" ], "previous": [ "MetaCyc:PWY-4762" ] } } }, { "id": "GO:0043639", "name": "benzoate catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-2503", "MetaCyc:PWY-283", "MetaCyc:PWY-7402" ], "previous": "N/A" } } }, { "id": "GO:0045063", "name": "T-helper 1 cell differentiation", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9942503 \"Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)\"" ], "previous": [ "Reactome:R-HSA-9942503 \"Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)\"" ] } } }, { "id": "GO:0045312", "name": "nor-spermidine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-6562" ], "previous": "N/A" } } }, { "id": "GO:0045490", "name": "pectin catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-1081", "MetaCyc:PWY-7246", "MetaCyc:PWY-7248" ], "previous": "N/A" } } }, { "id": "GO:0046363", "name": "ribitol catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-8394", "MetaCyc:RIBITOLUTIL-PWY" ], "previous": "N/A" } } }, { "id": "GO:0046951", "name": "ketone body biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY66-367", "Reactome:R-HSA-77111 \"Synthesis of Ketone Bodies\"" ], "previous": [ "Reactome:R-HSA-77111 \"Synthesis of Ketone Bodies\"" ] } } }, { "id": "GO:0051159", "name": "D-arabitol catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:DARABITOLUTIL-PWY", "MetaCyc:PWY-8392" ], "previous": "N/A" } } }, { "id": "GO:0051711", "name": "negative regulation of killing of cells of another organism", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-9662851 \"Anti-inflammatory response favouring Leishmania parasite infection\"" ] } } }, { "id": "GO:0052699", "name": "ergothioneine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7255", "MetaCyc:PWY-7550" ], "previous": "N/A" } } }, { "id": "GO:0055085", "name": "transmembrane transport", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-382556 \"ABC-family protein mediated transport\"", "Reactome:R-HSA-425407 \"SLC-mediated transmembrane transport\"", "Reactome:R-HSA-5223345 \"Miscellaneous transport and binding events\"" ], "previous": [ "Reactome:R-HSA-382556 \"ABC-family proteins mediated transport\"", "Reactome:R-HSA-425407 \"SLC-mediated transmembrane transport\"", "Reactome:R-HSA-5223345 \"Miscellaneous transport and binding events\"" ] } } }, { "id": "GO:0060271", "name": "cilium assembly", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5617833 \"Cilium Assembly\"", "Reactome:R-HSA-5620920 \"Cargo trafficking to the periciliary membrane\"" ], "previous": [ "Reactome:R-HSA-5617833 \"Cilium Assembly\"" ] } } }, { "id": "GO:0061678", "name": "Entner-Doudoroff pathway", "changes": { "xrefs": { "current": [ "MetaCyc:ENTNER-DOUDOROFF-PWY", "MetaCyc:NPGLUCAT-PWY", "MetaCyc:PWY-2221", "MetaCyc:PWY-8004" ], "previous": [ "MetaCyc:Entner-Doudoroff-Pathways" ] } } }, { "id": "GO:0070585", "name": "protein localization to mitochondrion", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1268020 \"Mitochondrial protein import\"" ], "previous": "N/A" } } }, { "id": "GO:0070981", "name": "L-asparagine biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:ASPARAGINE-BIOSYNTHESIS", "MetaCyc:ASPARAGINESYN-PWY", "MetaCyc:PWY490-4" ], "previous": [ "MetaCyc:ASPARAGINE-BIOSYNTHESIS", "MetaCyc:ASPARAGINESYN-PWY" ] } } }, { "id": "GO:0071267", "name": "L-methionine salvage", "changes": { "xrefs": { "current": [ "MetaCyc:ADENOSYLHOMOCYSCAT-PWY", "MetaCyc:PWY-4361", "MetaCyc:PWY-7174", "MetaCyc:PWY-7270", "MetaCyc:PWY-7527", "MetaCyc:PWY-7528", "MetaCyc:PWY-8132", "Reactome:R-HSA-1237112 \"Methionine salvage pathway\"" ], "previous": [ "MetaCyc:ADENOSYLHOMOCYSCAT-PWY", "MetaCyc:PWY-4361", "MetaCyc:PWY-7174", "MetaCyc:PWY-7270", "MetaCyc:PWY-7527", "MetaCyc:PWY-7528", "MetaCyc:PWY-8132" ] } } }, { "id": "GO:1901177", "name": "lycopene biosynthetic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-5942", "MetaCyc:PWY-6475" ], "previous": "N/A" } } }, { "id": "GO:1902777", "name": "6-sulfoquinovose(1-) catabolic process", "changes": { "xrefs": { "current": [ "MetaCyc:PWY-7446" ], "previous": "N/A" } } } ], "molecular_function": [ { "id": "GO:0000140", "name": "acylglycerone-phosphate reductase (NADP+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.101", "MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN", "MetaCyc:RXN-15046", "Reactome:R-HSA-75883 \"DHRS7B reduces GO3P to HXDG3P\"", "RHEA:17341", "RHEA:36175", "RHEA:40939", "RHEA:66452" ], "previous": [ "EC:1.1.1.101", "MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN", "MetaCyc:RXN-15046", "Reactome:R-HSA-75883 \"DHRS7B reduces GO3P to HXDG3P\"", "RHEA:17341", "RHEA:36175" ] } } }, { "id": "GO:0000252", "name": "3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.170", "Reactome:R-HSA-194642 \"4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one\"", "Reactome:R-HSA-194718 \"4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)\"", "Reactome:R-HSA-9945787 \"NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one\"", "Reactome:R-HSA-9945822 \"NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol\"", "RHEA:20673", "RHEA:33447", "RHEA:34771", "RHEA:60088", "RHEA:60096" ], "previous": [ "EC:1.1.1.170", "Reactome:R-HSA-194642 \"4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one\"", "Reactome:R-HSA-194718 \"4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)\"", "Reactome:R-HSA-9945787 \"NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one\"", "Reactome:R-HSA-9945822 \"NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol\"", "RHEA:34771" ] } } }, { "id": "GO:0000773", "name": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.71", "KEGG_REACTION:R01320", "KEGG_REACTION:R03424", "MetaCyc:2.1.1.71-RXN", "MetaCyc:RXN4FS-2", "RHEA:32735", "RHEA:32739", "RHEA:46112", "RHEA:70623", "RHEA:70743", "RHEA:70747", "RHEA:70755", "RHEA:70759", "RHEA:70767", "RHEA:70771" ], "previous": [ "EC:2.1.1.71", "KEGG_REACTION:R01320", "KEGG_REACTION:R03424", "MetaCyc:2.1.1.71-RXN", "MetaCyc:RXN4FS-2", "RHEA:32735", "RHEA:32739" ] } } }, { "id": "GO:0003810", "name": "protein-glutamine gamma-glutamyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.2.13", "MetaCyc:2.3.2.13-RXN", "Reactome:R-HSA-140851 \"fibrin multimer -> fibrin multimer, crosslinked + NH4+\"", "Reactome:R-HSA-6810894 \"Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking\"", "Reactome:R-HSA-9921091 \"IIb3:fibrin multimer ->IIb3:fibrin multimer, crosslinked + NH4+\"", "RHEA:54816" ], "previous": [ "EC:2.3.2.13", "MetaCyc:2.3.2.13-RXN", "Reactome:R-HSA-140851 \"fibrin multimer -> fibrin multimer, crosslinked + NH4+\"", "Reactome:R-HSA-6810894 \"Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking\"", "RHEA:54816" ] } } }, { "id": "GO:0003828", "name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.8", "MetaCyc:2.4.99.8-RXN", "Reactome:R-HSA-1022133 \"ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-4084978 \"ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues\"", "Reactome:R-HSA-422454 \"Polysialylation of NCAM1\"", "Reactome:R-HSA-9845587 \"ST8SIA5 transfers Neu5Ac to gangliosides\"", "RHEA:19313", "RHEA:41760", "RHEA:41768", "RHEA:41772", "RHEA:48288", "RHEA:48912", "RHEA:48924", "RHEA:48928", "RHEA:48932", "RHEA:77387" ], "previous": [ "EC:2.4.3.8", "MetaCyc:2.4.99.8-RXN", "Reactome:R-HSA-1022133 \"ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-4084978 \"ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues\"", "Reactome:R-HSA-422454 \"Polysialylation of NCAM1\"", "Reactome:R-HSA-9845587 \"ST8SIA5 transfers Neu5Ac to gangliosides\"", "RHEA:19313", "RHEA:48288", "RHEA:48912", "RHEA:48924", "RHEA:48932", "RHEA:77387" ] } } }, { "id": "GO:0003835", "name": "beta-galactoside alpha-2,6-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.1", "MetaCyc:RXN-18268", "Reactome:R-HSA-4085033 \"ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)\"", "Reactome:R-HSA-975902 \"ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-977071 \"ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens\"", "RHEA:11836", "RHEA:21552", "RHEA:52104", "RHEA:56268", "RHEA:82903", "RHEA:82947", "RHEA:82983" ], "previous": [ "EC:2.4.3.1", "MetaCyc:RXN-18268", "Reactome:R-HSA-4085033 \"ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)\"", "Reactome:R-HSA-975902 \"ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-977071 \"ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens\"", "RHEA:11836", "RHEA:21552", "RHEA:52104", "RHEA:56268", "RHEA:82903", "RHEA:82947" ] } } }, { "id": "GO:0003837", "name": "beta-ureidopropionase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.6", "MetaCyc:BETA-UREIDOPROPIONASE-RXN", "Reactome:R-HSA-73591 \"conversion of 3-ureidopropionate to beta-alanine\"", "Reactome:R-HSA-73620 \"conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate\"", "RHEA:11184" ], "previous": [ "EC:3.5.1.6", "MetaCyc:BETA-UREIDOPROPIONASE-RXN", "Reactome:R-HSA-73591 \"beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2\"", "Reactome:R-HSA-73620 \"beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2\"", "RHEA:11184" ] } } }, { "id": "GO:0003841", "name": "1-acylglycerol-3-phosphate O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.51", "MetaCyc:RXN-1623", "Reactome:R-HSA-1482539 \"1-acyl LPG is acylated to PG by LPGAT\"", "Reactome:R-HSA-1482547 \"1-acyl LPC is acylated to PC by LPCAT\"", "Reactome:R-HSA-1482548 \"1-acyl LPA is acylated to PA by AGPAT5 (OM)\"", "Reactome:R-HSA-1482598 \"1-acyl LPI is acylated to PI by MBOAT7\"", "Reactome:R-HSA-1482636 \"1-acyl LPS is acylated to PS by LPSAT\"", "Reactome:R-HSA-1482667 \"1-acyl LPE is acylated to PE by LPEAT\"", "Reactome:R-HSA-1482689 \"1-acyl LPG is acylated to PG by CRLS1 (IM)\"", "Reactome:R-HSA-1482894 \"CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)\"", "Reactome:R-HSA-75885 \"1-acyl LPA is acylated to PA by AGPAT (LPAAT)\"", "Reactome:R-HSA-8849345 \"LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine\"", "RHEA:19709", "RHEA:33187", "RHEA:33315", "RHEA:33319", "RHEA:35903", "RHEA:35907", "RHEA:35911", "RHEA:35915", "RHEA:37131", "RHEA:37135", "RHEA:37139", "RHEA:37143", "RHEA:37147", "RHEA:37151", "RHEA:37155", "RHEA:37159", "RHEA:37163", "RHEA:37171", "RHEA:37175", "RHEA:37179", "RHEA:37183", "RHEA:37187", "RHEA:37223", "RHEA:37427", "RHEA:37435", "RHEA:37439", "RHEA:37443", "RHEA:37451", "RHEA:37455", "RHEA:37595", "RHEA:37603", "RHEA:37607", "RHEA:42588", "RHEA:55304" ], "previous": [ "EC:2.3.1.51", "MetaCyc:RXN-1623", "Reactome:R-HSA-1482539 \"1-acyl LPG is acylated to PG by LPGAT\"", "Reactome:R-HSA-1482547 \"1-acyl LPC is acylated to PC by LPCAT\"", "Reactome:R-HSA-1482548 \"1-acyl LPA is acylated to PA by AGPAT5 (OM)\"", "Reactome:R-HSA-1482598 \"1-acyl LPI is acylated to PI by MBOAT7\"", "Reactome:R-HSA-1482636 \"1-acyl LPS is acylated to PS by LPSAT\"", "Reactome:R-HSA-1482667 \"1-acyl LPE is acylated to PE by LPEAT\"", "Reactome:R-HSA-1482689 \"1-acyl LPG is acylated to PG by CRLS1 (IM)\"", "Reactome:R-HSA-1482894 \"CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)\"", "Reactome:R-HSA-75885 \"1-acyl LPA is acylated to PA by AGPAT (LPAAT)\"", "Reactome:R-HSA-8849345 \"LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine\"", "RHEA:19709", "RHEA:33187", "RHEA:33315", "RHEA:33319", "RHEA:35911", "RHEA:35915", "RHEA:37135", "RHEA:37139", "RHEA:37151", "RHEA:37155", "RHEA:37159", "RHEA:37163", "RHEA:37171", "RHEA:37175", "RHEA:37179", "RHEA:37183", "RHEA:37187", "RHEA:37223", "RHEA:37427", "RHEA:37435", "RHEA:37439", "RHEA:37451", "RHEA:37595", "RHEA:37603", "RHEA:37607" ] } } }, { "id": "GO:0003846", "name": "2-acylglycerol O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.22", "MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-5696448 \"AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG\"", "Reactome:R-HSA-6800334 \"MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG\"", "RHEA:16741", "RHEA:32947", "RHEA:37911", "RHEA:38051", "RHEA:38059", "RHEA:38063", "RHEA:38067", "RHEA:38071", "RHEA:38075", "RHEA:38079", "RHEA:38083", "RHEA:38087", "RHEA:38467", "RHEA:39951", "RHEA:77271", "RHEA:77275", "RHEA:77279", "RHEA:77283", "RHEA:77287", "RHEA:77291", "RHEA:77539", "RHEA:77543", "RHEA:77547" ], "previous": [ "EC:2.3.1.22", "MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-5696448 \"AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG\"", "Reactome:R-HSA-6800334 \"MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG\"", "RHEA:16741", "RHEA:32947", "RHEA:38467", "RHEA:39951", "RHEA:77271", "RHEA:77275", "RHEA:77279", "RHEA:77283", "RHEA:77287", "RHEA:77291", "RHEA:77539", "RHEA:77543", "RHEA:77547" ] } } }, { "id": "GO:0003851", "name": "N-acylsphingosine galactosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.47", "MetaCyc:2.4.1.47-RXN", "Reactome:R-HSA-6785933 \"UGT8 transfers Gal from UDP-Gal to CERA\"", "RHEA:10856", "RHEA:13093", "RHEA:43400", "RHEA:44896" ], "previous": [ "EC:2.4.1.47", "MetaCyc:2.4.1.47-RXN", "Reactome:R-HSA-6785933 \"UGT8 transfers Gal from UDP-Gal to CERA\"", "RHEA:10856", "RHEA:13093", "RHEA:44896" ] } } }, { "id": "GO:0003853", "name": "short-chain 2-methyl fatty acyl-CoA dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.3.8.5", "KEGG_REACTION:R03169", "MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN", "RHEA:43780", "RHEA:44180", "RHEA:48256" ], "previous": [ "EC:1.3.8.5", "KEGG_REACTION:R03169", "MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN", "RHEA:43780", "RHEA:44180" ] } } }, { "id": "GO:0003854", "name": "3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.145", "MetaCyc:1.1.1.145-RXN", "Reactome:R-HSA-192097 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one\"", "Reactome:R-HSA-193789 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one\"", "Reactome:R-HSA-193816 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one\"", "Reactome:R-HSA-196350 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione\"", "Reactome:R-HSA-196372 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol\"", "RHEA:24076", "RHEA:43932", "RHEA:56932" ], "previous": [ "EC:1.1.1.145", "MetaCyc:1.1.1.145-RXN", "Reactome:R-HSA-192097 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one\"", "Reactome:R-HSA-193789 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one\"", "Reactome:R-HSA-193816 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one\"", "Reactome:R-HSA-196350 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione\"", "Reactome:R-HSA-196372 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol\"", "RHEA:24076", "RHEA:43932" ] } } }, { "id": "GO:0003857", "name": "(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.35", "MetaCyc:OHACYL-COA-DEHYDROG-RXN", "Reactome:R-HSA-193455 \"(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA\"", "Reactome:R-HSA-193508 \"(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA\"", "Reactome:R-HSA-389995 \"3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+\"", "Reactome:R-HSA-390251 \"HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA\"", "Reactome:R-HSA-508369 \"alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+\"", "Reactome:R-HSA-6809264 \"EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA\"", "Reactome:R-HSA-70837 \"alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+\"", "Reactome:R-HSA-77254 \"(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77283 \"(S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77303 \"(S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H\"", "Reactome:R-HSA-77312 \"(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H\"", "Reactome:R-HSA-77323 \"(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77331 \"(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77342 \"(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H\"", "RHEA:22432", "RHEA:30799", "RHEA:31143", "RHEA:31179", "RHEA:31187", "RHEA:31195", "RHEA:34851", "RHEA:40211", "RHEA:78919", "RHEA:78923", "RHEA:83003", "RHEA:84419", "RHEA:84683", "RHEA:84687", "UM-BBD_reactionID:r1063" ], "previous": [ "EC:1.1.1.35", "MetaCyc:OHACYL-COA-DEHYDROG-RXN", "Reactome:R-HSA-193455 \"(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA\"", "Reactome:R-HSA-193508 \"(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA\"", "Reactome:R-HSA-389995 \"3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+\"", "Reactome:R-HSA-390251 \"HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA\"", "Reactome:R-HSA-508369 \"alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+\"", "Reactome:R-HSA-6809264 \"EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA\"", "Reactome:R-HSA-70837 \"alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+\"", "Reactome:R-HSA-77254 \"(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77283 \"(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77303 \"(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H\"", "Reactome:R-HSA-77312 \"(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H\"", "Reactome:R-HSA-77323 \"(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77331 \"(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H\"", "Reactome:R-HSA-77342 \"(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H\"", "RHEA:22432", "RHEA:34851", "RHEA:40211", "RHEA:78919", "RHEA:78923", "UM-BBD_reactionID:r1063" ] } } }, { "id": "GO:0003875", "name": "ADP-ribosylarginine-[protein] hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.2.2.19", "MetaCyc:3.2.2.24-RXN {xref=\"skos:narrowMatch\"}", "MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN", "MetaCyc:RXN-8732", "RHEA:14493", "RHEA:14885", "RHEA:20784" ], "previous": [ "EC:3.2.2.19", "MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN", "MetaCyc:RXN-8732", "RHEA:14885", "RHEA:20784" ] } } }, { "id": "GO:0003883", "name": "CTP synthase activity", "changes": { "xrefs": { "current": [ "EC:6.3.4.2", "MetaCyc:CTPSYN-RXN", "Reactome:R-HSA-504054 \"Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS2)\"", "Reactome:R-HSA-73647 \"Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)\"", "RHEA:26426" ], "previous": [ "EC:6.3.4.2", "MetaCyc:CTPSYN-RXN", "Reactome:R-HSA-504054 \"UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]\"", "Reactome:R-HSA-73647 \"UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]\"", "RHEA:26426" ] } } }, { "id": "GO:0003909", "name": "DNA ligase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-174456 \"Joining of adjacent Okazaki fragments of the C-strand\"", "Reactome:R-HSA-175258 \"2-LTR formation due to circularization of viral DNA\"", "Reactome:R-HSA-5358592 \"DNA ligase I ligates single stranded nick in double stranded DNA\"", "Reactome:R-HSA-5649734 \"LIG3 ligates NEIL1,NEIL2-generated single strand break\"", "Reactome:R-HSA-5651789 \"LIG1 bound to POLB ligates SSB\"", "Reactome:R-HSA-5651805 \"LIG1 bound to APEX1 and PCNA ligates SSB\"", "Reactome:R-HSA-5686663 \"Completion of SSA\"", "Reactome:R-HSA-5687675 \"LIG3 ligates remaining SSBs in MMEJ\"", "Reactome:R-HSA-5690997 \"Ligation of newly synthesized repair patch to incised DNA in GG-NER\"", "Reactome:R-HSA-5693604 \"XRCC4:LIG4 ligates DNA DSB ends during NHEJ\"", "Reactome:R-HSA-6782227 \"Ligation of newly synthesized repair patch to incised DNA in TC-NER\"", "Reactome:R-HSA-69173 \"Joining of adjacent Okazaki fragments\"", "Reactome:R-HSA-73931 \"LIG3-mediated DNA ligation via the single-nucleotide replacement pathway\"" ], "previous": [ "Reactome:R-HSA-174456 \"Joining of adjacent Okazaki fragments of the C-strand\"", "Reactome:R-HSA-175258 \"2-LTR formation due to circularization of viral DNA\"", "Reactome:R-HSA-5358592 \"DNA ligase I ligates single stranded nick in double stranded DNA\"", "Reactome:R-HSA-5649734 \"LIG3 ligates NEIL1,NEIL2-generated single strand break\"", "Reactome:R-HSA-5651789 \"LIG1 bound to POLB ligates SSB\"", "Reactome:R-HSA-5651805 \"LIG1 bound to APEX1 and PCNA ligates SSB\"", "Reactome:R-HSA-5687675 \"LIG3 ligates remaining SSBs in MMEJ\"", "Reactome:R-HSA-5690997 \"Ligation of newly synthesized repair patch to incised DNA in GG-NER\"", "Reactome:R-HSA-5693604 \"XRCC4:LIG4 ligates DNA DSB ends during NHEJ\"", "Reactome:R-HSA-6782227 \"Ligation of newly synthesized repair patch to incised DNA in TC-NER\"", "Reactome:R-HSA-69173 \"Joining of adjacent Okazaki fragments\"", "Reactome:R-HSA-73931 \"LIG3-mediated DNA ligation via the single-nucleotide replacement pathway\"" ] } } }, { "id": "GO:0003920", "name": "GMP reductase activity", "changes": { "xrefs": { "current": [ "EC:1.7.1.7", "KEGG_REACTION:R01134", "MetaCyc:GMP-REDUCT-RXN", "Reactome:R-HSA-514604 \"GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)\"", "RHEA:17185" ], "previous": [ "EC:1.7.1.7", "KEGG_REACTION:R01134", "MetaCyc:GMP-REDUCT-RXN", "Reactome:R-HSA-514604 \"GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)\"", "RHEA:17185" ] } } }, { "id": "GO:0003968", "name": "RNA-directed RNA polymerase activity", "changes": { "xrefs": { "current": [ "EC:2.7.7.48", "MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN", "Reactome:R-HSA-168280 \"Priming and Initiation of Transcription\"", "Reactome:R-HSA-168301 \"Elongation, Polyadenylation and Termination\"", "Reactome:R-HSA-192624 \"cRNA Extension\"", "Reactome:R-HSA-192832 \"Initiation of cRNA Synthesis\"", "Reactome:R-HSA-192851 \"vRNA Extension\"", "Reactome:R-HSA-192916 \"Initiation of vRNA Synthesis\"", "Reactome:R-HSA-9681651 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9681674 \"nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement\"", "Reactome:R-HSA-9681840 \"RTC synthesizes SARS-CoV-1 plus strand genomic RNA\"", "Reactome:R-HSA-9682465 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9682563 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9685639 \"Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9685681 \"Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694277 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9694344 \"Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9694506 \"Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694549 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9694581 \"RTC synthesizes SARS-CoV-2 plus strand genomic RNA\"", "Reactome:R-HSA-9694605 \"nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement\"", "Reactome:R-HSA-9694792 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9828639 \"Transcription of respiratory syncytial virus subgenomic positive sense mRNAs\"", "Reactome:R-HSA-9834719 \"Synthesis of negative sense genomic RNA of respiratory syncytial virus\"", "Reactome:R-HSA-9834736 \"Synthesis of antigenomic RNA of human respiratory syncytial virus\"", "Reactome:R-HSA-9837511 \"Abortive replication of hRSV A\"", "Reactome:R-HSA-9922955 \"NS5 synthesizes minus strand genome\"", "Reactome:R-HSA-9923068 \"NS5 synthesizes plus strand genome\"", "Reactome:R-HSA-9944255 \"CHD6 negatively regulates influenza transcription\"", "Reactome:R-HSA-9944257 \"CHD6 negatively regulates positive strand RNA synthesis\"" ], "previous": [ "EC:2.7.7.48", "MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN", "Reactome:R-HSA-168280 \"Priming and Initiation of Transcription\"", "Reactome:R-HSA-168301 \"Elongation, Polyadenylation and Termination\"", "Reactome:R-HSA-192624 \"cRNA Extension\"", "Reactome:R-HSA-192832 \"Initiation of cRNA Synthesis\"", "Reactome:R-HSA-192851 \"vRNA Extension\"", "Reactome:R-HSA-192916 \"Initiation of vRNA Synthesis\"", "Reactome:R-HSA-9681651 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9681674 \"nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement\"", "Reactome:R-HSA-9681840 \"RTC synthesizes SARS-CoV-1 plus strand genomic RNA\"", "Reactome:R-HSA-9682465 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9682563 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9685639 \"Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9685681 \"Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694277 \"nsp8 generates RNA primers\"", "Reactome:R-HSA-9694344 \"Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching\"", "Reactome:R-HSA-9694506 \"Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs\"", "Reactome:R-HSA-9694549 \"RTC completes synthesis of the minus strand genomic RNA complement\"", "Reactome:R-HSA-9694581 \"RTC synthesizes SARS-CoV-2 plus strand genomic RNA\"", "Reactome:R-HSA-9694605 \"nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement\"", "Reactome:R-HSA-9694792 \"nsp12 misincorporates a nucleotide in nascent RNA minus strand\"", "Reactome:R-HSA-9828639 \"Transcription of respiratory syncytial virus subgenomic positive sense mRNAs\"", "Reactome:R-HSA-9834719 \"Synthesis of negative sense genomic RNA of respiratory syncytial virus\"", "Reactome:R-HSA-9834736 \"Synthesis of antigenomic RNA of human respiratory syncytial virus\"", "Reactome:R-HSA-9837511 \"Abortive replication of hRSV A\"", "Reactome:R-HSA-9922955 \"NS5 synthesizes minus strand genome\"", "Reactome:R-HSA-9923068 \"NS5 synthesizes plus strand genome\"" ] } } }, { "id": "GO:0003988", "name": "acetyl-CoA C-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.16", "MetaCyc:KETOACYLCOATHIOL-RXN", "Reactome:R-HSA-390250 \"3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77271 \"3-Oxotetradecanoyl-CoA+CoA-SH => Lauroyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77304 \"3-Oxopalmitoyl-CoA+CoA-SH => myristoyl-CoA+acetyl-CoA\"", "Reactome:R-HSA-77309 \"3-Oxododecanoyl-CoA+CoA-SH => Decanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77321 \"3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77329 \"3-Oxooctanoyl-CoA+CoA-SH => Hexanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77340 \"3-Oxodecanoyl-CoA+CoA-SH => Octanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-8874745 \"ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH\"", "RHEA:21564", "RHEA:31087", "RHEA:31091", "RHEA:31111", "RHEA:31183", "RHEA:31203", "RHEA:34799", "RHEA:35279", "RHEA:39131", "RHEA:39147", "RHEA:46312", "RHEA:47400", "RHEA:47444", "RHEA:47460", "RHEA:67224", "RHEA:78567", "RHEA:78583", "RHEA:78599", "RHEA:78639", "RHEA:78895", "RHEA:78899", "RHEA:78903", "RHEA:78907", "RHEA:82935", "RHEA:82943", "RHEA:83007", "RHEA:83083", "RHEA:83095", "RHEA:83099", "RHEA:83135", "RHEA:83219", "RHEA:83251", "RHEA:83331", "RHEA:83367", "RHEA:83383", "RHEA:83399", "RHEA:84447", "RHEA:84451", "RHEA:84455", "RHEA:84459", "RHEA:84695", "RHEA:84699", "RHEA:84703", "RHEA:84707", "RHEA:84711", "RHEA:84715", "RHEA:84839", "UM-BBD_reactionID:r1051" ], "previous": [ "EC:2.3.1.16", "MetaCyc:KETOACYLCOATHIOL-RXN", "Reactome:R-HSA-390250 \"3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA\"", "Reactome:R-HSA-77271 \"3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA\"", "Reactome:R-HSA-77304 \"3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA\"", "Reactome:R-HSA-77309 \"3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA\"", "Reactome:R-HSA-77321 \"3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA\"", "Reactome:R-HSA-77329 \"3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA\"", "Reactome:R-HSA-77340 \"3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA\"", "Reactome:R-HSA-8874745 \"ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH\"", "RHEA:21564", "RHEA:34799", "RHEA:46312", "RHEA:67224", "RHEA:78895", "RHEA:78899", "RHEA:78903", "RHEA:78907", "UM-BBD_reactionID:r1051" ] } } }, { "id": "GO:0003995", "name": "acyl-CoA dehydrogenase activity", "changes": { "xrefs": { "current": [ "MetaCyc:ACYLCOADEHYDROG-RXN", "Reactome:R-HSA-109341 \"dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA\"", "Reactome:R-HSA-5695980 \"ACAD10 dehydrogenates S-2MPDA-CoA\"", "Reactome:R-HSA-5695989 \"ACAD11 dehydrogenates BH-CoA\"", "Reactome:R-HSA-70800 \"alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2\"", "Reactome:R-HSA-70859 \"isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2\"", "Reactome:R-HSA-77263 \"lauroyl-CoA+FAD => 2-trans-Dodecenoyl-CoA+FADH2\"", "Reactome:R-HSA-77274 \"myristoyl-CoA+FAD => trans-tetradec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77299 \"palmitoyl-CoA+FAD => trans-Hexadec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77319 \"Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2\"", "Reactome:R-HSA-77327 \"Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77338 \"Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77345 \"Decanoyl-CoA+FAD => trans-Dec-2-enoyl-CoA+FADH2\"", "RHEA:44704" ], "previous": [ "MetaCyc:ACYLCOADEHYDROG-RXN", "Reactome:R-HSA-109341 \"dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA\"", "Reactome:R-HSA-5695980 \"ACAD10 dehydrogenates S-2MPDA-CoA\"", "Reactome:R-HSA-5695989 \"ACAD11 dehydrogenates BH-CoA\"", "Reactome:R-HSA-70800 \"alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2\"", "Reactome:R-HSA-70859 \"isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2\"", "Reactome:R-HSA-77263 \"lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2\"", "Reactome:R-HSA-77274 \"myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77299 \"palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77319 \"Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2\"", "Reactome:R-HSA-77327 \"Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77338 \"Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2\"", "Reactome:R-HSA-77345 \"Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2\"", "RHEA:44704" ] } } }, { "id": "GO:0004022", "name": "alcohol dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.1", "MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN", "MetaCyc:RXN-12448", "Reactome:R-HSA-2162078 \"abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+\"", "Reactome:R-HSA-71707 \"ethanol + NAD+ => acetaldehyde + NADH + H+\"", "RHEA:10736", "RHEA:10740", "RHEA:12216", "RHEA:12785", "RHEA:13221", "RHEA:15757", "RHEA:16317", "RHEA:16821", "RHEA:23552", "RHEA:30027", "RHEA:32343", "RHEA:34347", "RHEA:35463", "RHEA:35615", "RHEA:37167", "RHEA:38215", "RHEA:41984", "RHEA:42012", "RHEA:42016", "RHEA:42020", "RHEA:42052", "RHEA:42056", "RHEA:42060", "RHEA:42184", "RHEA:42188", "RHEA:43924", "RHEA:45120", "RHEA:48728", "RHEA:48748", "RHEA:48756", "RHEA:48760", "RHEA:50704", "RHEA:55936", "RHEA:58848", "RHEA:60632", "RHEA:60668", "RHEA:60672", "RHEA:60676", "RHEA:60712", "RHEA:60972", "RHEA:60976", "RHEA:60980", "RHEA:60984", "RHEA:60988", "RHEA:62064", "RHEA:62392", "RHEA:63260", "RHEA:63740", "RHEA:64060", "RHEA:64068", "RHEA:64516", "RHEA:64560", "RHEA:64692", "RHEA:64700", "RHEA:64704", "RHEA:68108", "RHEA:70231", "RHEA:75115", "RHEA:75419", "RHEA:75423", "RHEA:79419", "RHEA:80735", "RHEA:81603", "RHEA:86103", "RHEA:86111", "RHEA:86115", "RHEA:86119" ], "previous": [ "EC:1.1.1.1", "MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN", "MetaCyc:RXN-12448", "Reactome:R-HSA-2162078 \"abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+\"", "Reactome:R-HSA-71707 \"ethanol + NAD+ => acetaldehyde + NADH + H+\"", "RHEA:10736", "RHEA:10740" ] } } }, { "id": "GO:0004029", "name": "aldehyde dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.2.1.3", "MetaCyc:ALDHDEHYDROG-RXN", "Reactome:R-HSA-380608 \"5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid\"", "Reactome:R-HSA-389609 \"ALDH3A2-2 oxidizes pristanal to pristanate\"", "Reactome:R-HSA-5692261 \"ALDH3A2-1 oxidises HD2NAL to PALM\"", "Reactome:R-HSA-5696091 \"ALDH1B1 tetramer oxidises CH3CHO to CH3COOH\"", "Reactome:R-HSA-6808487 \"ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG\"", "Reactome:R-HSA-6808496 \"ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG\"", "Reactome:R-HSA-6813749 \"ALDH1A1 oxidises GA to DGA\"", "Reactome:R-HSA-71691 \"acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]\"", "Reactome:R-HSA-71723 \"acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]\"", "Reactome:R-HSA-9970035 \"Unknown ALDH oxidizes methylimidazolealdehyde\"", "Reactome:R-HSA-9971429 \"Unknown ALDH oxidizes 10-oxo-DECA\"", "Reactome:R-HSA-9971446 \"Unknown ALDH oxidizes 3-AAPNAL\"", "RHEA:16185", "RHEA:30867", "RHEA:30879", "RHEA:31043", "RHEA:31059", "RHEA:31215", "RHEA:31231", "RHEA:31243", "RHEA:31259", "RHEA:31299", "RHEA:31515", "RHEA:33803", "RHEA:34219", "RHEA:39039", "RHEA:42340", "RHEA:42384", "RHEA:45764", "RHEA:47932", "RHEA:59432", "RHEA:60688", "RHEA:60708", "RHEA:61632", "RHEA:67252", "RHEA:67256", "RHEA:69080", "RHEA:69084", "RHEA:69088", "RHEA:69164", "RHEA:69168", "RHEA:75119", "RHEA:76655", "RHEA:76667", "RHEA:81191", "RHEA:81419", "UM-BBD_reactionID:r0003", "UM-BBD_reactionID:r0023", "UM-BBD_reactionID:r0605", "Wikipedia:Aldehyde_dehydrogenase_(NAD+)" ], "previous": [ "EC:1.2.1.3", "MetaCyc:ALDHDEHYDROG-RXN", "Reactome:R-HSA-380608 \"5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid\"", "Reactome:R-HSA-389609 \"ALDH3A2-2 oxidizes pristanal to pristanate\"", "Reactome:R-HSA-5692261 \"ALDH3A2-1 oxidises HD2NAL to PALM\"", "Reactome:R-HSA-5696091 \"ALDH1B1 tetramer oxidises CH3CHO to CH3COOH\"", "Reactome:R-HSA-6808487 \"ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG\"", "Reactome:R-HSA-6808496 \"ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG\"", "Reactome:R-HSA-6813749 \"ALDH1A1 oxidises GA to DGA\"", "Reactome:R-HSA-71691 \"acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]\"", "Reactome:R-HSA-71723 \"acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]\"", "RHEA:16185", "RHEA:30867", "RHEA:30879", "RHEA:31043", "RHEA:31059", "RHEA:31215", "RHEA:31231", "RHEA:31243", "RHEA:31259", "RHEA:31299", "RHEA:31515", "RHEA:33803", "RHEA:34219", "RHEA:39039", "RHEA:42340", "RHEA:42384", "RHEA:45764", "RHEA:47152", "RHEA:47932", "RHEA:59432", "RHEA:60688", "RHEA:60708", "RHEA:61632", "RHEA:67252", "RHEA:67256", "RHEA:69080", "RHEA:69084", "RHEA:69088", "RHEA:69164", "RHEA:69168", "RHEA:75119", "RHEA:76655", "RHEA:76667", "RHEA:81191", "RHEA:81419", "UM-BBD_reactionID:r0003", "UM-BBD_reactionID:r0023", "UM-BBD_reactionID:r0605", "Wikipedia:Aldehyde_dehydrogenase_(NAD+)" ] } } }, { "id": "GO:0004046", "name": "aminoacylase activity", "changes": { "xrefs": { "current": [ "EC:3.5.1.14", "MetaCyc:AMINOACYLASE-RXN", "Reactome:R-HSA-5433074 \"ACY1:Zn2+ dimer hydrolyses mercapturic acids\"", "Reactome:R-HSA-5579081 \"Defective ACY1 does not hydrolyse mercapturic acids\"", "Reactome:R-HSA-9638046 \"ACY3:Zn2+ dimer hydrolyses mercapturic acids\"", "Reactome:R-HSA-9753944 \"ACY1:Zn2+ dimer deacetylates NAC to L-Cys\"", "RHEA:15565", "RHEA:36855", "RHEA:47124", "RHEA:49796", "RHEA:51300", "RHEA:51312", "RHEA:51316", "RHEA:51352", "RHEA:51356", "RHEA:51360", "RHEA:51444", "RHEA:51456", "RHEA:51460", "RHEA:52628", "RHEA:54184", "RHEA:54188", "RHEA:64108", "RHEA:64112", "RHEA:64116", "RHEA:64120", "RHEA:64124", "RHEA:64128", "RHEA:64132", "RHEA:64136", "RHEA:64140", "RHEA:64144", "RHEA:64156", "RHEA:64176", "RHEA:64180", "RHEA:64184", "RHEA:64188", "RHEA:64192", "RHEA:64196", "RHEA:64200", "RHEA:64208", "RHEA:64212", "RHEA:67368", "RHEA:67440", "RHEA:75515", "RHEA:81115", "RHEA:81119", "RHEA:81123" ], "previous": [ "EC:3.5.1.14", "MetaCyc:AMINOACYLASE-RXN", "Reactome:R-HSA-5433074 \"ACY1:Zn2+ dimer hydrolyses mercapturic acids\"", "Reactome:R-HSA-5579081 \"Defective ACY1 does not hydrolyse mercapturic acids\"", "Reactome:R-HSA-9638046 \"ACY3:Zn2+ dimer hydrolyses mercapturic acids\"", "Reactome:R-HSA-9753944 \"ACY1:Zn2+ dimer deacetylates NAC to L-Cys\"", "RHEA:15565", "RHEA:36855", "RHEA:52628", "RHEA:54184", "RHEA:67368", "RHEA:67440", "RHEA:75515", "RHEA:81115", "RHEA:81119", "RHEA:81123" ] } } }, { "id": "GO:0004090", "name": "carbonyl reductase (NADPH) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.184", "MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN", "Reactome:R-HSA-8937419 \"CBR3 reduces DOX to DOXOL\"", "RHEA:10724", "RHEA:12212", "RHEA:13829", "RHEA:16321", "RHEA:16817", "RHEA:18941", "RHEA:19257", "RHEA:25960", "RHEA:25964", "RHEA:31891", "RHEA:32339", "RHEA:32619", "RHEA:35607", "RHEA:36587", "RHEA:42500", "RHEA:42768", "RHEA:45116", "RHEA:47540", "RHEA:53820", "RHEA:62068", "RHEA:62072", "RHEA:62080", "RHEA:62216", "RHEA:62268", "RHEA:63476", "RHEA:63480", "RHEA:63504", "RHEA:64416", "RHEA:65056", "RHEA:65060", "RHEA:65496", "RHEA:68136", "RHEA:68140", "RHEA:68144", "RHEA:68148", "RHEA:70215", "RHEA:70219", "RHEA:74707", "RHEA:81575", "RHEA:81583", "RHEA:81719", "RHEA:82231", "RHEA:84223", "RHEA:85047", "RHEA:85103" ], "previous": [ "EC:1.1.1.184", "MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN", "Reactome:R-HSA-8937419 \"CBR3 reduces DOX to DOXOL\"", "RHEA:10724", "RHEA:12212", "RHEA:13829", "RHEA:16321", "RHEA:16817", "RHEA:18941", "RHEA:19257", "RHEA:25960", "RHEA:31891", "RHEA:32339", "RHEA:32619", "RHEA:35607", "RHEA:36587", "RHEA:42500", "RHEA:42768", "RHEA:45116", "RHEA:47540", "RHEA:53820", "RHEA:62068", "RHEA:62216", "RHEA:62268", "RHEA:63476", "RHEA:63480", "RHEA:63504", "RHEA:64416", "RHEA:65056", "RHEA:65060", "RHEA:65496", "RHEA:68136", "RHEA:68140", "RHEA:68144", "RHEA:68148", "RHEA:70215", "RHEA:70219", "RHEA:74707", "RHEA:81575", "RHEA:81583", "RHEA:81719", "RHEA:82231", "RHEA:84223", "RHEA:85047", "RHEA:85103" ] } } }, { "id": "GO:0004126", "name": "cytidine deaminase activity", "changes": { "xrefs": { "current": [ "EC:3.5.4.5", "MetaCyc:CYTIDEAM-RXN", "MetaCyc:CYTIDEAM2-RXN", "Reactome:R-HSA-73608 \"deamination of 2'-Deoxycytidine to 2'-Deoxyuridine\"", "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"", "Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine\"", "RHEA:13433", "RHEA:16069" ], "previous": [ "EC:3.5.4.5", "MetaCyc:CYTIDEAM-RXN", "MetaCyc:CYTIDEAM2-RXN", "Reactome:R-HSA-73608 \"(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)\"", "Reactome:R-HSA-83677 \"C4 deamination of cytidine\"", "Reactome:R-HSA-9817513 \"AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine\"", "RHEA:13433", "RHEA:16069" ] } } }, { "id": "GO:0004155", "name": "6,7-dihydropteridine reductase activity", "changes": { "xrefs": { "current": [ "EC:1.5.1.34", "MetaCyc:1.5.1.34-RXN", "Reactome:R-HSA-71130 \"q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+\"", "RHEA:17865", "RHEA:17869", "RHEA:32247", "RHEA:32251" ], "previous": [ "EC:1.5.1.34", "MetaCyc:1.5.1.34-RXN", "Reactome:R-HSA-71130 \"q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+\"", "RHEA:17865", "RHEA:17869" ] } } }, { "id": "GO:0004157", "name": "dihydropyrimidinase activity", "changes": { "xrefs": { "current": [ "EC:3.5.2.2", "MetaCyc:DIHYDROPYRIMIDINASE-RXN", "Reactome:R-HSA-73589 \"conversion of 5,6-dihydrouracil to 3-ureidopropionate\"", "Reactome:R-HSA-73618 \"conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate\"", "RHEA:16121" ], "previous": [ "EC:3.5.2.2", "MetaCyc:DIHYDROPYRIMIDINASE-RXN", "Reactome:R-HSA-73589 \"5,6-dihydrouracil + H2O => beta-ureidopropionate\"", "Reactome:R-HSA-73618 \"5,6-dihydrothymine + H2O => beta-ureidoisobutyrate\"", "RHEA:16121" ] } } }, { "id": "GO:0004165", "name": "delta(3)-delta(2)-enoyl-CoA isomerase activity", "changes": { "xrefs": { "current": [ "EC:5.3.3.8", "MetaCyc:ENOYL-COA-DELTA-ISOM-RXN", "MetaCyc:RXN-7836", "MetaCyc:RXN-7931", "Reactome:R-HSA-109338 \"Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA\"", "Reactome:R-HSA-6809808 \"ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA\"", "RHEA:23716", "RHEA:29847", "RHEA:45228", "RHEA:45736", "RHEA:45748", "RHEA:45752", "RHEA:45900", "RHEA:46044", "RHEA:46068", "RHEA:47464", "RHEA:47476", "RHEA:49852", "RHEA:49932", "RHEA:77195", "RHEA:83231", "RHEA:84487", "RHEA:84491", "RHEA:84547", "RHEA:84555", "RHEA:84559", "RHEA:84563", "RHEA:84843" ], "previous": [ "EC:5.3.3.8", "MetaCyc:ENOYL-COA-DELTA-ISOM-RXN", "MetaCyc:RXN-7836", "MetaCyc:RXN-7931", "Reactome:R-HSA-109338 \"Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA\"", "Reactome:R-HSA-6809808 \"ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA\"", "RHEA:23716", "RHEA:29847", "RHEA:45228", "RHEA:45748", "RHEA:45900", "RHEA:46044", "RHEA:77195" ] } } }, { "id": "GO:0004170", "name": "dUTP diphosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.23", "KEGG_REACTION:R02100", "MetaCyc:DUTP-PYROP-RXN", "Reactome:R-HSA-73666 \"hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate\"", "RHEA:10248" ], "previous": [ "EC:3.6.1.23", "KEGG_REACTION:R02100", "MetaCyc:DUTP-PYROP-RXN", "Reactome:R-HSA-73666 \"dUTP + H2O => dUMP + pyrophosphate\"", "RHEA:10248" ] } } }, { "id": "GO:0004175", "name": "endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.99.-", "Reactome:R-HSA-1168640 \"Ubiquitinated IkB is degraded\"", "Reactome:R-HSA-1234159 \"Proteasome proteolyzes ub-HIF-alpha\"", "Reactome:R-HSA-1236935 \"Proteasomal cleavage of substrate (26S proteasome catalyst)\"", "Reactome:R-HSA-1236970 \"Proteasomal clevage of exogenous antigen (26S proteasome catalyst)\"", "Reactome:R-HSA-1251997 \"Cleavage of ERBB4m80 by gamma-scretase complex\"", "Reactome:R-HSA-1433374 \"Processing of SCF isoform 1\"", "Reactome:R-HSA-1504193 \"Ubiquitinated DVL is degraded by the proteasome\"", "Reactome:R-HSA-174058 \"Degradation of multiubiquitinated Cdh1\"", "Reactome:R-HSA-174105 \"Degradation of multiubiquitinated cell cycle proteins\"", "Reactome:R-HSA-174202 \"Degradation of multiubiquitinated Securin\"", "Reactome:R-HSA-174203 \"SCF-mediated degradation of Emi1\"", "Reactome:R-HSA-174255 \"Degradation multiubiquitinated Cyclin A\"", "Reactome:R-HSA-180573 \"Degradation of ubiquitinated CD4\"", "Reactome:R-HSA-180603 \"Proteosome-mediated degradation of APOBEC3G\"", "Reactome:R-HSA-187574 \"Degradation of ubiquitinated p27/p21 by the 26S proteasome\"", "Reactome:R-HSA-188191 \"APC/C:Cdh1-mediated degradation of Skp2\"", "Reactome:R-HSA-193682 \"gamma-secretase cleaves the p75NTR transmembrane domain\"", "Reactome:R-HSA-209061 \"Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex\"", "Reactome:R-HSA-211715 \"Proteasome mediated degradation of PAK-2p34\"", "Reactome:R-HSA-2130282 \"Degradation of ubiquitinated beta catenin by the proteasome\"", "Reactome:R-HSA-2213200 \"Release of endostatin-like peptides\"", "Reactome:R-HSA-264458 \"Proteasome mediated degradation of COP1\"", "Reactome:R-HSA-353125 \"26S proteosome degrades ODC holoenzyme complex\"", "Reactome:R-HSA-3640874 \"Ub-RibC-AXIN is degraded by the proteasome\"", "Reactome:R-HSA-3928656 \"gamma-secretase cleaves EPHB2\"", "Reactome:R-HSA-450466 \"AUF1:mRNA complex is degraded\"", "Reactome:R-HSA-4608855 \"PRICKLE1 is degraded by the proteasome\"", "Reactome:R-HSA-4641256 \"Ubiquitinated AXIN is degraded by the proteasome\"", "Reactome:R-HSA-4641260 \"Ubiquitinated DVL1 is degraded by the proteasome\"", "Reactome:R-HSA-5358340 \"Autoproteolytic cleavage of Hh precursors\"", "Reactome:R-HSA-5358460 \"HPE SHH variants don't undergo autoproteolytic cleavage\"", "Reactome:R-HSA-5362448 \"Hh C-terminal fragments are degraded by the proteasome\"", "Reactome:R-HSA-5387392 \"processing defective Hh variants are degraded by the proteasome\"", "Reactome:R-HSA-5607724 \"26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex\"", "Reactome:R-HSA-5607731 \"26S proteasome processes p-7S-p100:RELB to form p52:RELB\"", "Reactome:R-HSA-5610754 \"GLI3 is partially degraded by the proteasome to yield the GLI3 repressor\"", "Reactome:R-HSA-5610757 \"GLI2 is degraded by the proteasome\"", "Reactome:R-HSA-5610758 \"GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP\"", "Reactome:R-HSA-5610760 \"GLI1 is degraded by the proteasome after ubiquitination by ITCH\"", "Reactome:R-HSA-5635854 \"GLI2,3 are degraded by the proteasome\"", "Reactome:R-HSA-5635868 \"ub-GLI is degraded by the proteasome\"", "Reactome:R-HSA-5658430 \"NF1 is degraded by the proteasome\"", "Reactome:R-HSA-5668481 \"Protesomal degradation of K48polyUb-TRAF3\"", "Reactome:R-HSA-5668520 \"26Sproteasome degrades K48polyUb-NIK\"", "Reactome:R-HSA-5687112 \"MAPK6 is degraded by the 26S proteasome\"", "Reactome:R-HSA-5693081 \"FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)\"", "Reactome:R-HSA-6784628 \"PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer\"", "Reactome:R-HSA-6784676 \"PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer\"", "Reactome:R-HSA-68825 \"Ubiquitinated geminin is degraded by the proteasome\"", "Reactome:R-HSA-68948 \"Ubiquitinated Orc1 is degraded by the proteasome\"", "Reactome:R-HSA-69016 \"Ubiquitinated Cdc6 is degraded by the proteasome\"", "Reactome:R-HSA-69600 \"Proteolytic degradation of ubiquitinated-Cdc25A\"", "Reactome:R-HSA-74730 \"Insulin degradation\"", "Reactome:R-HSA-75825 \"Proteasome mediated degradation of Cyclin D1\"", "Reactome:R-HSA-8849797 \"Membrane proteases cleave Profilaggrin producing Filaggrin\"", "Reactome:R-HSA-8850992 \"Proteasome degrades polyubiquitinated PTEN\"", "Reactome:R-HSA-8852354 \"GTSE1 facilitates proteasome-mediated degradation of TP53\"", "Reactome:R-HSA-8854044 \"Proteasome degrades AURKA ubiquitinated by SCF-FBXL7\"", "Reactome:R-HSA-8854071 \"Proteasome-mediated degradation of PolyUb-FBXL7\"", "Reactome:R-HSA-8866553 \"misfolded CFTR is degraded by the 26S proteasome\"", "Reactome:R-HSA-8866858 \"CFTR F508del is degraded by the 26S proteasome\"", "Reactome:R-HSA-8932355 \"26S proteasome degrades Ub-NFE2L2\"", "Reactome:R-HSA-8934819 \"Cytoplasmic proteases cleave Profilaggrin producing Filaggrin\"", "Reactome:R-HSA-8939801 \"26S proteasome degrades PolyUb-RUNX2\"", "Reactome:R-HSA-8952408 \"Polyubiquitinated RUNX3 is degraded by the proteasome\"", "Reactome:R-HSA-8957265 \"26S proteasome degrades TP73 polyubiquitinated by ITCH\"", "Reactome:R-HSA-9008110 \"Proteasome degrades polyubiquitinated RUNX2\"", "Reactome:R-HSA-9009362 \"Proteasome degrades PolyUb-RUNX2\"", "Reactome:R-HSA-9010096 \"Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)\"", "Reactome:R-HSA-9011313 \"Proteasome degrades ubiquitinated ROBO3.1\"", "Reactome:R-HSA-9604642 \"Proteasome degrades ubiquitinated NICD4\"", "Reactome:R-HSA-9614271 \"Autocleavage of ADGRG6\"", "Reactome:R-HSA-9755303 \"26S proteasome degrades HIFalpha\"", "Reactome:R-HSA-9755306 \"ub UBXN7 is degraded by the 26S proteasome\"", "Reactome:R-HSA-9760521 \"Unknown peptidase cleaves pro-STa\"", "Reactome:R-HSA-9762096 \"Ub,pS335,S338,T NFE2L2 is degraded\"", "Reactome:R-HSA-9766223 \"Proteasome-dependent degradation of ubiquitinated CDH1\"", "Reactome:R-HSA-983150 \"Proteasomal cleavage of substrate\"", "Reactome:R-HSA-983158 \"Trimming of peptides in ER\"", "Reactome:R-HSA-9839376 \"TGFBR3(784-851) degradation\"", "Reactome:R-HSA-9906017 \"Unknown peptidase cleaves UQCRFS1 subunit\"", "Reactome:R-HSA-9908101 \"Maturation of the canonical 20S core particle\"", "Reactome:R-HSA-9908105 \"Maturation of the 20S immunoproteasome core particle\"", "Reactome:R-HSA-9908108 \"Maturation of the 20S thymoproteasome core particle\"", "Reactome:R-HSA-9908780 \"Maturation of the preholospermatoproteasome\"", "Reactome:R-HSA-9912636 \"Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)\"", "Reactome:R-HSA-9912655 \"Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)\"", "Reactome:R-HSA-9912747 \"Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)\"", "Reactome:R-HSA-9912751 \"Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)\"", "Reactome:R-HSA-9929352 \"Ubiquitinated CD274 is degraded by the 26S proteasome\"", "Reactome:R-HSA-9929486 \"SPOP-mediated degradation of CD274 by 26S Proteosome\"", "Reactome:R-HSA-9931314 \"Proteasomal degradation of polyUb-p-S195-CD274\"", "Reactome:R-HSA-9934884 \"Proteolysis of K48polyUb,p-S-CRY1,2\"", "Reactome:R-HSA-9934887 \"Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2\"", "Reactome:R-HSA-9934893 \"Proteolysis of K48polyUb-K,p-S-PER1,2,3\"", "Reactome:R-HSA-9949676 \"The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer\"", "Reactome:R-HSA-9954728 \"The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide\"", "Reactome:R-HSA-9958874 \"26S proteasome degrades ubiquitinated RAC1, CDC42\"" ], "previous": [ "EC:3.4.99.-", "Reactome:R-HSA-1168640 \"Ubiquitinated IkB is degraded\"", "Reactome:R-HSA-1234159 \"Proteasome proteolyzes ub-HIF-alpha\"", "Reactome:R-HSA-1236935 \"Proteasomal cleavage of substrate (26S proteasome catalyst)\"", "Reactome:R-HSA-1236970 \"Proteasomal clevage of exogenous antigen (26S proteasome catalyst)\"", "Reactome:R-HSA-1251997 \"Cleavage of ERBB4m80 by gamma-scretase complex\"", "Reactome:R-HSA-1433374 \"Processing of SCF isoform 1\"", "Reactome:R-HSA-1504193 \"Ubiquitinated DVL is degraded by the proteasome\"", "Reactome:R-HSA-174058 \"Degradation of multiubiquitinated Cdh1\"", "Reactome:R-HSA-174105 \"Degradation of multiubiquitinated cell cycle proteins\"", "Reactome:R-HSA-174202 \"Degradation of multiubiquitinated Securin\"", "Reactome:R-HSA-174203 \"SCF-mediated degradation of Emi1\"", "Reactome:R-HSA-174255 \"Degradation multiubiquitinated Cyclin A\"", "Reactome:R-HSA-180573 \"Degradation of ubiquitinated CD4\"", "Reactome:R-HSA-180603 \"Proteosome-mediated degradation of APOBEC3G\"", "Reactome:R-HSA-187574 \"Degradation of ubiquitinated p27/p21 by the 26S proteasome\"", "Reactome:R-HSA-188191 \"APC/C:Cdh1-mediated degradation of Skp2\"", "Reactome:R-HSA-193682 \"gamma-secretase cleaves the p75NTR transmembrane domain\"", "Reactome:R-HSA-209061 \"Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex\"", "Reactome:R-HSA-211715 \"Proteasome mediated degradation of PAK-2p34\"", "Reactome:R-HSA-2130282 \"Degradation of ubiquitinated beta catenin by the proteasome\"", "Reactome:R-HSA-2213200 \"Release of endostatin-like peptides\"", "Reactome:R-HSA-264458 \"Proteasome mediated degradation of COP1\"", "Reactome:R-HSA-353125 \"26S proteosome degrades ODC holoenzyme complex\"", "Reactome:R-HSA-3640874 \"Ub-RibC-AXIN is degraded by the proteasome\"", "Reactome:R-HSA-3928656 \"gamma-secretase cleaves EPHB2\"", "Reactome:R-HSA-450466 \"AUF1:mRNA complex is degraded\"", "Reactome:R-HSA-4608855 \"PRICKLE1 is degraded by the proteasome\"", "Reactome:R-HSA-4641256 \"Ubiquitinated AXIN is degraded by the proteasome\"", "Reactome:R-HSA-4641260 \"Ubiquitinated DVL1 is degraded by the proteasome\"", "Reactome:R-HSA-5358340 \"Autoproteolytic cleavage of Hh precursors\"", "Reactome:R-HSA-5358460 \"HPE SHH variants don't undergo autoproteolytic cleavage\"", "Reactome:R-HSA-5362448 \"Hh C-terminal fragments are degraded by the proteasome\"", "Reactome:R-HSA-5387392 \"processing defective Hh variants are degraded by the proteasome\"", "Reactome:R-HSA-5607724 \"26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex\"", "Reactome:R-HSA-5607731 \"26S proteasome processes p-7S-p100:RELB to form p52:RELB\"", "Reactome:R-HSA-5610754 \"GLI3 is partially degraded by the proteasome to yield the GLI3 repressor\"", "Reactome:R-HSA-5610757 \"GLI2 is degraded by the proteasome\"", "Reactome:R-HSA-5610758 \"GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP\"", "Reactome:R-HSA-5610760 \"GLI1 is degraded by the proteasome after ubiquitination by ITCH\"", "Reactome:R-HSA-5635854 \"GLI2,3 are degraded by the proteasome\"", "Reactome:R-HSA-5635868 \"ub-GLI is degraded by the proteasome\"", "Reactome:R-HSA-5658430 \"NF1 is degraded by the proteasome\"", "Reactome:R-HSA-5668481 \"Protesomal degradation of K48polyUb-TRAF3\"", "Reactome:R-HSA-5668520 \"26Sproteasome degrades K48polyUb-NIK\"", "Reactome:R-HSA-5687112 \"MAPK6 is degraded by the 26S proteasome\"", "Reactome:R-HSA-5693081 \"FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)\"", "Reactome:R-HSA-6784628 \"PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer\"", "Reactome:R-HSA-6784676 \"PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer\"", "Reactome:R-HSA-68825 \"Ubiquitinated geminin is degraded by the proteasome\"", "Reactome:R-HSA-68948 \"Ubiquitinated Orc1 is degraded by the proteasome\"", "Reactome:R-HSA-69016 \"Ubiquitinated Cdc6 is degraded by the proteasome\"", "Reactome:R-HSA-69600 \"Proteolytic degradation of ubiquitinated-Cdc25A\"", "Reactome:R-HSA-74730 \"Insulin degradation\"", "Reactome:R-HSA-75825 \"Proteasome mediated degradation of Cyclin D1\"", "Reactome:R-HSA-8849797 \"Membrane proteases cleave Profilaggrin producing Filaggrin\"", "Reactome:R-HSA-8850992 \"Proteasome degrades polyubiquitinated PTEN\"", "Reactome:R-HSA-8852354 \"GTSE1 facilitates proteasome-mediated degradation of TP53\"", "Reactome:R-HSA-8854044 \"Proteasome degrades AURKA ubiquitinated by SCF-FBXL7\"", "Reactome:R-HSA-8854071 \"Proteasome-mediated degradation of PolyUb-FBXL7\"", "Reactome:R-HSA-8866553 \"misfolded CFTR is degraded by the 26S proteasome\"", "Reactome:R-HSA-8866858 \"CFTR F508del is degraded by the 26S proteasome\"", "Reactome:R-HSA-8932355 \"26S proteasome degrades Ub-NFE2L2\"", "Reactome:R-HSA-8934819 \"Cytoplasmic proteases cleave Profilaggrin producing Filaggrin\"", "Reactome:R-HSA-8939801 \"26S proteasome degrades PolyUb-RUNX2\"", "Reactome:R-HSA-8952408 \"Polyubiquitinated RUNX3 is degraded by the proteasome\"", "Reactome:R-HSA-8957265 \"26S proteasome degrades TP73 polyubiquitinated by ITCH\"", "Reactome:R-HSA-9008110 \"Proteasome degrades polyubiquitinated RUNX2\"", "Reactome:R-HSA-9009362 \"Proteasome degrades PolyUb-RUNX2\"", "Reactome:R-HSA-9010096 \"Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)\"", "Reactome:R-HSA-9011313 \"Proteasome degrades ubiquitinated ROBO3.1\"", "Reactome:R-HSA-9604642 \"Proteasome degrades ubiquitinated NICD4\"", "Reactome:R-HSA-9614271 \"Autocleavage of ADGRG6\"", "Reactome:R-HSA-9755303 \"26S proteasome degrades HIFalpha\"", "Reactome:R-HSA-9755306 \"ub UBXN7 is degraded by the 26S proteasome\"", "Reactome:R-HSA-9760521 \"Unknown peptidase cleaves pro-STa\"", "Reactome:R-HSA-9762096 \"Ub,pS335,S338,T NFE2L2 is degraded\"", "Reactome:R-HSA-9766223 \"Proteasome-dependent degradation of ubiquitinated CDH1\"", "Reactome:R-HSA-983150 \"Proteasomal cleavage of substrate\"", "Reactome:R-HSA-983158 \"Trimming of peptides in ER\"", "Reactome:R-HSA-9839376 \"TGFBR3(784-851) degradation\"", "Reactome:R-HSA-9906017 \"Unknown peptidase cleaves UQCRFS1 subunit\"", "Reactome:R-HSA-9908101 \"Maturation of the canonical 20S core particle\"", "Reactome:R-HSA-9908105 \"Maturation of the 20S immunoproteasome core particle\"", "Reactome:R-HSA-9908108 \"Maturation of the 20S thymoproteasome core particle\"", "Reactome:R-HSA-9908780 \"Maturation of the preholospermatoproteasome\"", "Reactome:R-HSA-9912636 \"Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)\"", "Reactome:R-HSA-9912655 \"Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)\"", "Reactome:R-HSA-9912747 \"Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)\"", "Reactome:R-HSA-9912751 \"Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)\"", "Reactome:R-HSA-9929352 \"Ubiquitinated CD274 is degraded by the 26S proteasome\"", "Reactome:R-HSA-9929486 \"SPOP-mediated degradation of CD274 by 26S Proteosome\"", "Reactome:R-HSA-9931314 \"Proteasomal degradation of polyUb-p-S195-CD274\"", "Reactome:R-HSA-9934884 \"Proteolysis of K48polyUb,p-S-CRY1,2\"", "Reactome:R-HSA-9934887 \"Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2\"", "Reactome:R-HSA-9934893 \"Proteolysis of K48polyUb-K,p-S-PER1,2,3\"", "Reactome:R-HSA-9949676 \"The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer\"", "Reactome:R-HSA-9954728 \"The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide\"" ] } } }, { "id": "GO:0004185", "name": "serine-type carboxypeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.16.-", "EC:3.4.16.2", "EC:3.4.16.5", "EC:3.4.16.6", "MetaCyc:3.4.16.2-RXN", "MetaCyc:3.4.16.5-RXN", "Reactome:R-HSA-9857945 \"prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst)\"" ], "previous": [ "EC:3.4.16.-", "EC:3.4.16.2", "EC:3.4.16.5", "EC:3.4.16.6", "MetaCyc:3.4.16.2-RXN", "MetaCyc:3.4.16.5-RXN", "Reactome:R-HSA-158251 \"prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer\"" ] } } }, { "id": "GO:0004222", "name": "metalloendopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.24.-", "EC:3.4.24.11", "EC:3.4.24.14", "EC:3.4.24.17", "EC:3.4.24.18", "EC:3.4.24.19", "EC:3.4.24.21", "EC:3.4.24.22", "EC:3.4.24.23", "EC:3.4.24.24", "EC:3.4.24.3", "EC:3.4.24.34", "EC:3.4.24.35", "EC:3.4.24.37", "EC:3.4.24.55", "EC:3.4.24.56", "EC:3.4.24.57", "EC:3.4.24.59", "EC:3.4.24.61", "EC:3.4.24.65", "EC:3.4.24.69", "EC:3.4.24.7", "EC:3.4.24.70", "EC:3.4.24.71", "EC:3.4.24.72", "MetaCyc:3.4.24.11-RXN", "MetaCyc:3.4.24.14-RXN", "MetaCyc:3.4.24.17-RXN", "MetaCyc:3.4.24.18-RXN", "MetaCyc:3.4.24.19-RXN", "MetaCyc:3.4.24.21-RXN", "MetaCyc:3.4.24.22-RXN", "MetaCyc:3.4.24.23-RXN", "MetaCyc:3.4.24.24-RXN", "MetaCyc:3.4.24.35-RXN", "MetaCyc:3.4.24.37-RXN", "MetaCyc:3.4.24.55-RXN", "MetaCyc:3.4.24.56-RXN", "MetaCyc:3.4.24.57-RXN", "MetaCyc:3.4.24.59-RXN", "MetaCyc:3.4.24.61-RXN", "MetaCyc:3.4.24.64-RXN", "MetaCyc:3.4.24.69-RXN", "MetaCyc:3.4.24.70-RXN", "MetaCyc:3.4.24.71-RXN", "MetaCyc:3.4.24.72-RXN", "Reactome:R-HSA-1168777 \"Metalloprotease cleavage of GHR\"", "Reactome:R-HSA-1251992 \"Cleavage of P-ERBB4jmA isoforms by ADAM17\"", "Reactome:R-HSA-1299476 \"MPP cleaves targeting peptide (presequence) of inner membrane precursors\"", "Reactome:R-HSA-1299478 \"MPP cleaves targeting peptide (presequence) of matrix precursors\"", "Reactome:R-HSA-1454757 \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\"", "Reactome:R-HSA-1454822 \"Collagen type I degradation by MMP1,2,8,13, PRSS2\"", "Reactome:R-HSA-1458433 \"Collagen type I degradation by MMP14\"", "Reactome:R-HSA-1474196 \"Collagen type II degradation by MMP14\"", "Reactome:R-HSA-1474210 \"Collagen type III degradation by MMP14\"", "Reactome:R-HSA-1474213 \"Collagen type III degradation by MMP1,8,9,13\"", "Reactome:R-HSA-1564112 \"Collagen type VI degradation by MMP2,9,11\"", "Reactome:R-HSA-1564117 \"Collagen type XIV degradation by MMP9,13\"", "Reactome:R-HSA-1564120 \"Collagen type VII degradation by MMP1,2,3\"", "Reactome:R-HSA-1564142 \"Collagen type IV degradation by MMP2,3,4,9,10,12\"", "Reactome:R-HSA-1564143 \"Collagen type X degradation by MMP1,2\"", "Reactome:R-HSA-1564164 \"Collagen type V degradation by MMP2,9,10\"", "Reactome:R-HSA-1564169 \"Collagen type VIII degradation by MMP1\"", "Reactome:R-HSA-1564179 \"Collagen type XI degradation by MMP1,2,3,9\"", "Reactome:R-HSA-1564184 \"Collagen type IX degradation by MMP3,13\"", "Reactome:R-HSA-1592310 \"Aggrecan degradation by ADAMTSs\"", "Reactome:R-HSA-1655851 \"S2P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-177946 \"Pro-EGF is cleaved to form mature EGF\"", "Reactome:R-HSA-181567 \"botC LC cleaves target cell STX1\"", "Reactome:R-HSA-194793 \"botC LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194796 \"botB LC cleaves target cell VAMP2\"", "Reactome:R-HSA-194800 \"botE LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194808 \"botF LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194809 \"botD LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194818 \"botA LC cleaves target cell SNAP25\"", "Reactome:R-HSA-2002428 \"Removal of fibrillar collagen N-propeptides\"", "Reactome:R-HSA-2002440 \"Removal of fibrillar collagen C-propeptides\"", "Reactome:R-HSA-2022141 \"Prolysyl oxidase activation\"", "Reactome:R-HSA-2168046 \"Collagen type XII degradation by MMP12\"", "Reactome:R-HSA-2168982 \"Collagen type XVI degradation by MMP9\"", "Reactome:R-HSA-2179402 \"Active MMP3 can cleave pro-HBEGF to form active HBEGF\"", "Reactome:R-HSA-2473584 \"Collagen type III degradation by MMP15\"", "Reactome:R-HSA-2473594 \"Collagen type II degradation by MMP15\"", "Reactome:R-HSA-2473596 \"Collagen type I degradation by MMP15\"", "Reactome:R-HSA-2484882 \"Collagen type X degradation by MMP3, 13\"", "Reactome:R-HSA-2485111 \"Collagen type III degradation by MMP10\"", "Reactome:R-HSA-2485148 \"Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13\"", "Reactome:R-HSA-2514790 \"Elastin degradation by MMP14\"", "Reactome:R-HSA-2514831 \"Fibrillin-1 degradation by MMP14\"", "Reactome:R-HSA-2533874 \"Laminin-511 degradation by MMP14\"", "Reactome:R-HSA-2533944 \"Fibronectin degradation by MMP10\"", "Reactome:R-HSA-2533950 \"Fibronectin degradation by MMP14\"", "Reactome:R-HSA-2533965 \"NID1 degradation by MMP14, MMP15\"", "Reactome:R-HSA-2533970 \"NID1 degradation by MMP3, 7\"", "Reactome:R-HSA-2534240 \"HSPG2 (perlecan) degradation by MMP14, MMP15\"", "Reactome:R-HSA-2534248 \"DCN (decorin) degradation by MMP2, MMP3, MMP7\"", "Reactome:R-HSA-2537499 \"Gelatin degradation by MMP19\"", "Reactome:R-HSA-264758 \"BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1\"", "Reactome:R-HSA-3371385 \"TNF- is cleaved by ADAM17 (TACE)\"", "Reactome:R-HSA-3788075 \"Brevican degradation by ADAMTS4, ADAMTS5\"", "Reactome:R-HSA-3791149 \"Brevican degradation by MMP1, 2, 3, 7,8,10,13,19\"", "Reactome:R-HSA-3791155 \"Laminin-322 degradation by MMP14\"", "Reactome:R-HSA-3791295 \"Aggrecan degradation by MMP1,2,3,7,9,12,13\"", "Reactome:R-HSA-3791319 \"NID1 degradation by MMP19\"", "Reactome:R-HSA-381435 \"Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381518 \"PAAP-A proteolyzes IGF:IGFBP4\"", "Reactome:R-HSA-381537 \"PAPP-A2 proteolyzes IGF:IGFBP5:ALS\"", "Reactome:R-HSA-3827958 \"E-cadherin degradation by MMP9, KLK7\"", "Reactome:R-HSA-3828025 \"DCN (decorin) degradation by MMP14\"", "Reactome:R-HSA-4086205 \"OPN (osteopontin) degradation by MMP3, MMP7\"", "Reactome:R-HSA-420818 \"MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-4224014 \"E-cadherin degradation by ADAM10, ADAM15\"", "Reactome:R-HSA-5228578 \"tetX LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250606 \"botD LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250892 \"botF LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250962 \"botG LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250978 \"botG LC cleaves target cell VAMP1\"", "Reactome:R-HSA-5333671 \"CLCAs self cleave\"", "Reactome:R-HSA-5362793 \"Hh-Np is cleaved by ADAM17 to promote ligand shedding\"", "Reactome:R-HSA-5694082 \"XK:KEL:Zn2+ cleaves EDN3\"", "Reactome:R-HSA-6784620 \"MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)\"", "Reactome:R-HSA-8867344 \"OMA1 hydrolyses OPA1\"", "Reactome:R-HSA-8874122 \"MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874187 \"MBTPS2 (S2P) cleaves CREB3L2\"", "Reactome:R-HSA-8874192 \"MBTPS2 (S2P) cleaves CREB3\"", "Reactome:R-HSA-8874194 \"MBTPS2 (S2P) cleaves CREB3L1\"", "Reactome:R-HSA-8874195 \"MBTPS2 (S2P) cleaves CREB3L4\"", "Reactome:R-HSA-8874201 \"MBTPS2 (S2P) cleaves CREB3L3\"", "Reactome:R-HSA-8876868 \"ECE1 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8877620 \"ECE2 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8940554 \"MMP2 cleaves OPTC\"", "Reactome:R-HSA-8940561 \"MMP7 cleaves OPTC\"", "Reactome:R-HSA-8940641 \"THOP1 cleaves oligopeptide fragment (8-16aa)\"", "Reactome:R-HSA-8940959 \"Neurolysin degrades neurotensin\"", "Reactome:R-HSA-8942302 \"MMP13 cleaves OPTC\"", "Reactome:R-HSA-8943959 \"MMP2, MMP9 cleave SCUBE3\"", "Reactome:R-HSA-8949649 \"PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)\"", "Reactome:R-HSA-8949659 \"AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU\"", "Reactome:R-HSA-8949668 \"YME1L1 proteolyzes unassembled proSMDT1\"", "Reactome:R-HSA-9010034 \"ADAM10:Zn2+:TSPANs cleaves APP(18-770)\"", "Reactome:R-HSA-9624272 \"MMPs cleave HB-EGF\"", "Reactome:R-HSA-9822532 \"ADAMTS13 cleaves VWF multimer\"", "Reactome:R-HSA-9824402 \"ADAMTS13 variant does not cleave VWF multimer\"", "Reactome:R-HSA-9840408 \"OMA1 cleaves DELE1\"", "Reactome:R-HSA-9840532 \"OMA1 self-cleaves\"", "Reactome:R-HSA-9840564 \"OMA1 hydrolyzes YME1L1\"", "Reactome:R-HSA-9844241 \"ADAMTS13 cleaves VWF variant multimer\"", "Reactome:R-HSA-9934645 \"ADAMTS13 cleaves VWF multimer bound to FVIII\"" ], "previous": [ "EC:3.4.24.-", "EC:3.4.24.11", "EC:3.4.24.14", "EC:3.4.24.17", "EC:3.4.24.18", "EC:3.4.24.19", "EC:3.4.24.21", "EC:3.4.24.22", "EC:3.4.24.23", "EC:3.4.24.24", "EC:3.4.24.3", "EC:3.4.24.34", "EC:3.4.24.35", "EC:3.4.24.37", "EC:3.4.24.55", "EC:3.4.24.56", "EC:3.4.24.57", "EC:3.4.24.59", "EC:3.4.24.61", "EC:3.4.24.65", "EC:3.4.24.69", "EC:3.4.24.7", "EC:3.4.24.70", "EC:3.4.24.71", "EC:3.4.24.72", "MetaCyc:3.4.24.11-RXN", "MetaCyc:3.4.24.14-RXN", "MetaCyc:3.4.24.17-RXN", "MetaCyc:3.4.24.18-RXN", "MetaCyc:3.4.24.19-RXN", "MetaCyc:3.4.24.21-RXN", "MetaCyc:3.4.24.22-RXN", "MetaCyc:3.4.24.23-RXN", "MetaCyc:3.4.24.24-RXN", "MetaCyc:3.4.24.35-RXN", "MetaCyc:3.4.24.37-RXN", "MetaCyc:3.4.24.55-RXN", "MetaCyc:3.4.24.56-RXN", "MetaCyc:3.4.24.57-RXN", "MetaCyc:3.4.24.59-RXN", "MetaCyc:3.4.24.61-RXN", "MetaCyc:3.4.24.64-RXN", "MetaCyc:3.4.24.69-RXN", "MetaCyc:3.4.24.70-RXN", "MetaCyc:3.4.24.71-RXN", "MetaCyc:3.4.24.72-RXN", "Reactome:R-HSA-1168777 \"Metalloprotease cleavage of GHR\"", "Reactome:R-HSA-1251992 \"Cleavage of P-ERBB4jmA isoforms by ADAM17\"", "Reactome:R-HSA-1299476 \"MPP cleaves targeting peptide (presequence) of inner membrane precursors\"", "Reactome:R-HSA-1299478 \"MPP cleaves targeting peptide (presequence) of matrix precursors\"", "Reactome:R-HSA-1454757 \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\"", "Reactome:R-HSA-1454822 \"Collagen type I degradation by MMP1,2,8,13, PRSS2\"", "Reactome:R-HSA-1458433 \"Collagen type I degradation by MMP14\"", "Reactome:R-HSA-1474196 \"Collagen type II degradation by MMP14\"", "Reactome:R-HSA-1474210 \"Collagen type III degradation by MMP14\"", "Reactome:R-HSA-1474213 \"Collagen type III degradation by MMP1,8,9,13\"", "Reactome:R-HSA-1564112 \"Collagen type VI degradation by MMP2,9,11\"", "Reactome:R-HSA-1564117 \"Collagen type XIV degradation by MMP9,13\"", "Reactome:R-HSA-1564120 \"Collagen type VII degradation by MMP1,2,3\"", "Reactome:R-HSA-1564142 \"Collagen type IV degradation by MMP2,3,4,9,10,12\"", "Reactome:R-HSA-1564143 \"Collagen type X degradation by MMP1,2\"", "Reactome:R-HSA-1564164 \"Collagen type V degradation by MMP2,9,10\"", "Reactome:R-HSA-1564169 \"Collagen type VIII degradation by MMP1\"", "Reactome:R-HSA-1564179 \"Collagen type XI degradation by MMP1,2,3,9\"", "Reactome:R-HSA-1564184 \"Collagen type IX degradation by MMP3,13\"", "Reactome:R-HSA-1592310 \"Aggrecan degradation by ADAMTSs\"", "Reactome:R-HSA-1655851 \"S2P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-177946 \"Pro-EGF is cleaved to form mature EGF\"", "Reactome:R-HSA-181567 \"botC LC cleaves target cell STX1\"", "Reactome:R-HSA-194793 \"botC LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194796 \"botB LC cleaves target cell VAMP2\"", "Reactome:R-HSA-194800 \"botE LC cleaves target cell SNAP25\"", "Reactome:R-HSA-194808 \"botF LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194809 \"botD LC cleaves target cell VAMP1\"", "Reactome:R-HSA-194818 \"botA LC cleaves target cell SNAP25\"", "Reactome:R-HSA-2002428 \"Removal of fibrillar collagen N-propeptides\"", "Reactome:R-HSA-2002440 \"Removal of fibrillar collagen C-propeptides\"", "Reactome:R-HSA-2022141 \"Prolysyl oxidase activation\"", "Reactome:R-HSA-2168046 \"Collagen type XII degradation by MMP12\"", "Reactome:R-HSA-2168982 \"Collagen type XVI degradation by MMP9\"", "Reactome:R-HSA-2179402 \"Active MMP3 can cleave pro-HBEGF to form active HBEGF\"", "Reactome:R-HSA-2473584 \"Collagen type III degradation by MMP15\"", "Reactome:R-HSA-2473594 \"Collagen type II degradation by MMP15\"", "Reactome:R-HSA-2473596 \"Collagen type I degradation by MMP15\"", "Reactome:R-HSA-2484882 \"Collagen type X degradation by MMP3, 13\"", "Reactome:R-HSA-2485111 \"Collagen type III degradation by MMP10\"", "Reactome:R-HSA-2485148 \"Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13\"", "Reactome:R-HSA-2514790 \"Elastin degradation by MMP14\"", "Reactome:R-HSA-2514831 \"Fibrillin-1 degradation by MMP14\"", "Reactome:R-HSA-2533874 \"Laminin-511 degradation by MMP14\"", "Reactome:R-HSA-2533944 \"Fibronectin degradation by MMP10\"", "Reactome:R-HSA-2533950 \"Fibronectin degradation by MMP14\"", "Reactome:R-HSA-2533965 \"NID1 degradation by MMP14, MMP15\"", "Reactome:R-HSA-2533970 \"NID1 degradation by MMP3, 7\"", "Reactome:R-HSA-2534240 \"HSPG2 (perlecan) degradation by MMP14, MMP15\"", "Reactome:R-HSA-2534248 \"DCN (decorin) degradation by MMP2, MMP3, MMP7\"", "Reactome:R-HSA-2537499 \"Gelatin degradation by MMP19\"", "Reactome:R-HSA-264758 \"BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1\"", "Reactome:R-HSA-3371385 \"TNF- is cleaved by ADAM17 (TACE)\"", "Reactome:R-HSA-3788075 \"Brevican degradation by ADAMTS4, ADAMTS5\"", "Reactome:R-HSA-3791149 \"Brevican degradation by MMP1, 2, 3, 7,8,10,13,19\"", "Reactome:R-HSA-3791155 \"Laminin-322 degradation by MMP14\"", "Reactome:R-HSA-3791295 \"Aggrecan degradation by MMP1,2,3,7,9,12,13\"", "Reactome:R-HSA-3791319 \"NID1 degradation by MMP19\"", "Reactome:R-HSA-381435 \"Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381518 \"PAAP-A proteolyzes IGF:IGFBP4\"", "Reactome:R-HSA-381537 \"PAPP-A2 proteolyzes IGF:IGFBP5:ALS\"", "Reactome:R-HSA-3827958 \"E-cadherin degradation by MMP9, KLK7\"", "Reactome:R-HSA-3828025 \"DCN (decorin) degradation by MMP14\"", "Reactome:R-HSA-4086205 \"OPN (osteopontin) degradation by MMP3, MMP7\"", "Reactome:R-HSA-420818 \"MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-4224014 \"E-cadherin degradation by ADAM10, ADAM15\"", "Reactome:R-HSA-5228578 \"tetX LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250606 \"botD LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250892 \"botF LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250962 \"botG LC cleaves target cell VAMP2\"", "Reactome:R-HSA-5250978 \"botG LC cleaves target cell VAMP1\"", "Reactome:R-HSA-5333671 \"CLCAs self cleave\"", "Reactome:R-HSA-5362793 \"Hh-Np is cleaved by ADAM17 to promote ligand shedding\"", "Reactome:R-HSA-5694082 \"XK:KEL:Zn2+ cleaves EDN3\"", "Reactome:R-HSA-6784620 \"MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)\"", "Reactome:R-HSA-8867344 \"OMA1 hydrolyses OPA1\"", "Reactome:R-HSA-8874122 \"MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874187 \"MBTPS2 (S2P) cleaves CREB3L2\"", "Reactome:R-HSA-8874192 \"MBTPS2 (S2P) cleaves CREB3\"", "Reactome:R-HSA-8874194 \"MBTPS2 (S2P) cleaves CREB3L1\"", "Reactome:R-HSA-8874195 \"MBTPS2 (S2P) cleaves CREB3L4\"", "Reactome:R-HSA-8874201 \"MBTPS2 (S2P) cleaves CREB3L3\"", "Reactome:R-HSA-8876868 \"ECE1 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8877620 \"ECE2 cleaves EDN1(53-90)\"", "Reactome:R-HSA-8940554 \"MMP2 cleaves OPTC\"", "Reactome:R-HSA-8940561 \"MMP7 cleaves OPTC\"", "Reactome:R-HSA-8940641 \"THOP1 cleaves oligopeptide fragment (8-16aa)\"", "Reactome:R-HSA-8940959 \"Neurolysin degrades neurotensin\"", "Reactome:R-HSA-8942302 \"MMP13 cleaves OPTC\"", "Reactome:R-HSA-8943959 \"MMP2, MMP9 cleave SCUBE3\"", "Reactome:R-HSA-8949649 \"PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)\"", "Reactome:R-HSA-8949659 \"AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU\"", "Reactome:R-HSA-8949668 \"YME1L1 proteolyzes unassembled proSMDT1\"", "Reactome:R-HSA-9010034 \"ADAM10:Zn2+:TSPANs cleaves APP(18-770)\"", "Reactome:R-HSA-9624272 \"MMPs cleave HB-EGF\"", "Reactome:R-HSA-9822532 \"ADAMTS13 cleaves VWF multimer\"", "Reactome:R-HSA-9824402 \"ADAMTS13 variant does not cleave VWF multimer\"", "Reactome:R-HSA-9840408 \"OMA1 cleaves DELE1\"", "Reactome:R-HSA-9840532 \"OMA1 self-cleaves\"", "Reactome:R-HSA-9840564 \"OMA1 hydrolyzes YME1L1\"", "Reactome:R-HSA-9844241 \"ADAMTS13 cleaves VWF variant multimer\"" ] } } }, { "id": "GO:0004252", "name": "serine-type endopeptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.21.-", "EC:3.4.21.1", "EC:3.4.21.10", "EC:3.4.21.102", "EC:3.4.21.20", "EC:3.4.21.21", "EC:3.4.21.22", "EC:3.4.21.26", "EC:3.4.21.27", "EC:3.4.21.34", "EC:3.4.21.35", "EC:3.4.21.36", "EC:3.4.21.38", "EC:3.4.21.39", "EC:3.4.21.4", "EC:3.4.21.41", "EC:3.4.21.42", "EC:3.4.21.43", "EC:3.4.21.45", "EC:3.4.21.46", "EC:3.4.21.47", "EC:3.4.21.48", "EC:3.4.21.5", "EC:3.4.21.53", "EC:3.4.21.54", "EC:3.4.21.59", "EC:3.4.21.6", "EC:3.4.21.61", "EC:3.4.21.62", "EC:3.4.21.68", "EC:3.4.21.69", "EC:3.4.21.7", "EC:3.4.21.71", "EC:3.4.21.73", "EC:3.4.21.75", "EC:3.4.21.78", "EC:3.4.21.79", "EC:3.4.21.83", "EC:3.4.21.88", "EC:3.4.21.9", "EC:3.4.21.92", "EC:3.4.21.93", "EC:3.4.21.94", "Reactome:R-HSA-114697 \"Activated thrombin (factor IIa) cleaves PAR3,4, activating them\"", "Reactome:R-HSA-1181152 \"Cleavage of NODAL proprotein\"", "Reactome:R-HSA-139893 \"Granzyme-B activates BID by cleavage\"", "Reactome:R-HSA-140599 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides\"", "Reactome:R-HSA-140664 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)\"", "Reactome:R-HSA-140696 \"factor V -> factor Va + factor V activation peptide (thrombin catalyst)\"", "Reactome:R-HSA-140700 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)\"", "Reactome:R-HSA-140769 \"factor VII -> factor VIIa\"", "Reactome:R-HSA-140840 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B\"", "Reactome:R-HSA-140870 \"thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate\"", "Reactome:R-HSA-141026 \"Activated protein C cleaves factor Va to factor Vi intermediate form\"", "Reactome:R-HSA-141040 \"Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C\"", "Reactome:R-HSA-1454843 \"E-cadherin degradation by MMP3, MMP7 and plasmin\"", "Reactome:R-HSA-1474197 \"Collagen type II degradation by MMP1,3,8,13,PRSS2\"", "Reactome:R-HSA-1566962 \"Elastin degradation by elastin-degrading extracellular proteinases\"", "Reactome:R-HSA-1566979 \"Laminin-332 degradation by laminin-322 degrading extracellular proteinases\"", "Reactome:R-HSA-1566981 \"Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS\"", "Reactome:R-HSA-158137 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer\"", "Reactome:R-HSA-158164 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)\"", "Reactome:R-HSA-158300 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)\"", "Reactome:R-HSA-158313 \"factor XII -> factor XIIa\"", "Reactome:R-HSA-158333 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)\"", "Reactome:R-HSA-158419 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)\"", "Reactome:R-HSA-158744 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin\"", "Reactome:R-HSA-158747 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)\"", "Reactome:R-HSA-158750 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin\"", "Reactome:R-HSA-158766 \"fibrin multimer, crosslinked -> fibrin digestion products (plasmin)\"", "Reactome:R-HSA-158925 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)\"", "Reactome:R-HSA-158942 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-158982 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)\"", "Reactome:R-HSA-1592270 \"NID1 degradation by MMP1, 9, 12, ELANE\"", "Reactome:R-HSA-1592278 \"Autocatalytic activation of proMMP2\"", "Reactome:R-HSA-1592297 \"Full activation of MMP1\"", "Reactome:R-HSA-1592314 \"HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)\"", "Reactome:R-HSA-1592316 \"Initial activation of proMMP1\"", "Reactome:R-HSA-1592362 \"Activation of proMMP7 by MMP3\"", "Reactome:R-HSA-1592371 \"Initial activation of proMMP3\"", "Reactome:R-HSA-1592398 \"Activation of proMMP8\"", "Reactome:R-HSA-1592436 \"Initial activation of proMMP9 by MMPs\"", "Reactome:R-HSA-159728 \"Furin cleaves pro-prothrombin to prothrombin\"", "Reactome:R-HSA-159733 \"Furin cleaves pro-factor X to factor X\"", "Reactome:R-HSA-159771 \"Furin cleaves pro-protein C to protein C\"", "Reactome:R-HSA-159773 \"Furin cleaves pro-protein S to protein S\"", "Reactome:R-HSA-159796 \"Furin cleaves pro-factor IX to factor IX\"", "Reactome:R-HSA-159868 \"Furin cleaves pro-factor VII to factor VII\"", "Reactome:R-HSA-1602458 \"Activation of proMMP10\"", "Reactome:R-HSA-1602466 \"Activation of MT-MMPs by FURIN\"", "Reactome:R-HSA-1602473 \"Autocatalytic activation of MMP1\"", "Reactome:R-HSA-1602484 \"Activation of proMMP11 by FURIN\"", "Reactome:R-HSA-1602488 \"Initial activation of proMMP13 by plasmin and trypsin\"", "Reactome:R-HSA-1604359 \"Initial activation of proMMP2 by MMP1, 7\"", "Reactome:R-HSA-1604360 \"Initial activation of proMMP2 by MMP14\"", "Reactome:R-HSA-1604368 \"Autocatalytic activation of bound proMMP2\"", "Reactome:R-HSA-1604690 \"Activation of MMP9 intermediate form by MMPs\"", "Reactome:R-HSA-1604712 \"Initial activation of proMMP7 by trypsin\"", "Reactome:R-HSA-1604722 \"Activation of proMMP9 by proteases\"", "Reactome:R-HSA-1604731 \"Autocatalytic activation of MMP3\"", "Reactome:R-HSA-1604732 \"Autocatalytic activation of proMMP13\"", "Reactome:R-HSA-1604741 \"Initial activation of proMMP13 by MMP14 (MT1-MMP)\"", "Reactome:R-HSA-1604752 \"Initial activation of proMMP13 by MMP3\"", "Reactome:R-HSA-1604763 \"Autocatalytic activation of MMP7\"", "Reactome:R-HSA-163798 \"Furin cleaves pro-protein Z to protein Z\"", "Reactome:R-HSA-163843 \"Furin cleaves pro-GAS6 to GAS6\"", "Reactome:R-HSA-1655842 \"S1P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-166753 \"Conversion of C4 into C4a and C4b\"", "Reactome:R-HSA-166792 \"Conversion of C2 into C2a and C2b\"", "Reactome:R-HSA-166817 \"Cleavage of C3 by C3 convertases\"", "Reactome:R-HSA-170844 \"Latent TGF-beta-1 is cleaved by FURIN\"", "Reactome:R-HSA-171288 \"Cleavage of the viral Env gp160 precursor polyprotein\"", "Reactome:R-HSA-173626 \"Activation of C1r\"", "Reactome:R-HSA-173631 \"Activation of C1s\"", "Reactome:R-HSA-173680 \"Activation of C5\"", "Reactome:R-HSA-173745 \"Factor D cleaves C3(H2O)-bound Factor B\"", "Reactome:R-HSA-174551 \"Formation of alternative pathway C5 convertase\"", "Reactome:R-HSA-1799329 \"Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein\"", "Reactome:R-HSA-183122 \"Factor D cleaves C3b-bound Factor B\"", "Reactome:R-HSA-183130 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a\"", "Reactome:R-HSA-186785 \"PDGF-AA clevage by Furin\"", "Reactome:R-HSA-187020 \"Part of pro-beta-NGF is processed to mature beta-NGF\"", "Reactome:R-HSA-1912369 \"NOTCH precursor cleaved to form mature NOTCH\"", "Reactome:R-HSA-1912372 \"Fringe-modified Pre-NOTCH is cleaved by FURIN\"", "Reactome:R-HSA-2022411 \"Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))\"", "Reactome:R-HSA-2129357 \"Fibrillin C-terminal processing\"", "Reactome:R-HSA-2168923 \"Collagen type XVIII endostatin release\"", "Reactome:R-HSA-2168960 \"Collagen type XVII ectodomain shedding\"", "Reactome:R-HSA-2172405 \"Collagen type XXIII ectodomain shedding\"", "Reactome:R-HSA-2214330 \"Cleavage of collagen VII NC2 region by BMP1\"", "Reactome:R-HSA-2471621 \"Endostatin degradation by cathepsins\"", "Reactome:R-HSA-2471842 \"Collagen type XXV ectomain shedding\"", "Reactome:R-HSA-2482180 \"Collagen type VIII degradation by ELANE\"", "Reactome:R-HSA-2514772 \"Fibrillin-1 degradation by MMP3, CTSK, CTSL2\"", "Reactome:R-HSA-2514823 \"Fibrillin-1 degradation by ELANE\"", "Reactome:R-HSA-2534160 \"HSPG2 (perlecan) degradation by MMP13, CTSS\"", "Reactome:R-HSA-2534206 \"E-cadherin degradation by PS1:NCSTN (Gamma-secretase)\"", "Reactome:R-HSA-2534260 \"E-cadherin degradation by caspase-3 and calpain-1\"", "Reactome:R-HSA-265301 \"Corticotropin cleavage from POMC\"", "Reactome:R-HSA-3244626 \"DENV protease NS2B3 cleaves STING\"", "Reactome:R-HSA-3266557 \"Factor I cleaves iC3b\"", "Reactome:R-HSA-3785684 \"Fibronectin degradation by CTSG\"", "Reactome:R-HSA-3788061 \"Fibronectin degradation by ADAM8\"", "Reactome:R-HSA-381135 \"MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-381446 \"Thrombin proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381461 \"Plasmin proteolyzes IGF:IGFBP-3:ALS\"", "Reactome:R-HSA-381466 \"Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-3814820 \"HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1\"", "Reactome:R-HSA-381500 \"Cathepsin G proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381798 \"PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1\"", "Reactome:R-HSA-382061 \"Extracellular processing of novel PDGFs\"", "Reactome:R-HSA-3928657 \"MMP2,9 cleave EPHB\"", "Reactome:R-HSA-400459 \"Signal peptidase hydrolyzes preproGLP-1 to proGLP-1\"", "Reactome:R-HSA-400492 \"PCSK1 hydrolyzes proGIP to GIP\"", "Reactome:R-HSA-400496 \"Signal peptidase hydrolyzes preproGIP to proGIP\"", "Reactome:R-HSA-422021 \"PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin\"", "Reactome:R-HSA-422051 \"Cleavage of the signal peptide of Preproghrelin\"", "Reactome:R-HSA-5210912 \"Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5210935 \"Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5578783 \"CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)\"", "Reactome:R-HSA-5591040 \"Activated protein C cleaves Factor Va intermediate form for Factor Va\"", "Reactome:R-HSA-5607002 \"Activated protein C cleaves factor VIIIa\"", "Reactome:R-HSA-5691512 \"APEH hydrolyses NAc-Ser-protein\"", "Reactome:R-HSA-6800198 \"HPN heterodimer cleaves pro-MST1 to form MST1 dimer\"", "Reactome:R-HSA-6800200 \"HPN heterodimer cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6800299 \"HGFAC cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6801687 \"PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)\"", "Reactome:R-HSA-6807224 \"Furin cleaves pro-BGLAP to BGLAP\"", "Reactome:R-HSA-8849826 \"ST14 hydrolyzes and activates KLK5\"", "Reactome:R-HSA-8849857 \"KLK5 cleaves and activates CELA2\"", "Reactome:R-HSA-8850831 \"KLK5 cleaves and activates KLK8\"", "Reactome:R-HSA-8852716 \"Thrombin, ELANE cleave C5\"", "Reactome:R-HSA-8855825 \"HTRA1 hydrolyzes ACAN (Aggrecan)\"", "Reactome:R-HSA-8865275 \"PDGF-BB clevage by Furin\"", "Reactome:R-HSA-8865276 \"PDGF-AB clevage by Furin\"", "Reactome:R-HSA-8874145 \"MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874186 \"MBTPS1 (S1P) cleaves CREB3L4\"", "Reactome:R-HSA-8874204 \"MBTPS1 (S1P) cleaves CREB3\"", "Reactome:R-HSA-8874205 \"MBTPS1 (S1P) cleaves CREB3L2\"", "Reactome:R-HSA-8874206 \"MBTPS1 (S1P) cleaves CREB3L3\"", "Reactome:R-HSA-8874212 \"MBTPS1 (S1P) cleaves CREB3L1\"", "Reactome:R-HSA-9023178 \"PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))\"", "Reactome:R-HSA-9023196 \"PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)\"", "Reactome:R-HSA-9023626 \"DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023627 \"DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023632 \"DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9023633 \"DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9033490 \"TYSND1 cleaves PHYH\"", "Reactome:R-HSA-9033506 \"TYSND1 cleaves AGPS\"", "Reactome:R-HSA-9033515 \"TYSND1 cleaves ACOX1\"", "Reactome:R-HSA-9033520 \"TYSND1 cleaves TYSND1\"", "Reactome:R-HSA-9033524 \"TYSND1 cleaves SCP2\"", "Reactome:R-HSA-9033529 \"TYSND1 cleaves ACAA1\"", "Reactome:R-HSA-9033530 \"TYSND1 cleaves HSD17B4\"", "Reactome:R-HSA-9653249 \"Cleavage of factor XII variant by activated thrombin\"", "Reactome:R-HSA-9655046 \"Cleavage of FXII variant by KLKB1\"", "Reactome:R-HSA-9655840 \"FXIIa is cleaved to -FXIIa\"", "Reactome:R-HSA-9655850 \"prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)\"", "Reactome:R-HSA-9662786 \"FURIN cleaves ADAM17\"", "Reactome:R-HSA-9666383 \"F8 variant is not cleaved by thrombin\"", "Reactome:R-HSA-9668253 \"Hyperactivation of factor X by FVIIIa:FIXa R384L\"", "Reactome:R-HSA-9668365 \"FVIIIa variant:FIXa does not convert FX to the active FXa\"", "Reactome:R-HSA-9670874 \"FIXa variant:FVIIIa does not convert FX to the active FXa\"", "Reactome:R-HSA-9673223 \"FIX(29-461) variant is not activated (factor XIa catalyst)\"", "Reactome:R-HSA-9678434 \"factor X -> factor Xa + factor X activation peptide (emicizumab:FIXa catalyst)\"", "Reactome:R-HSA-9686710 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9686731 \"TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9694287 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9694661 \"TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9698988 \"Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid\"", "Reactome:R-HSA-9699007 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9708859 \"Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it\"", "Reactome:R-HSA-9710106 \"ELANE cleaves GSDMD\"", "Reactome:R-HSA-9710263 \"GZMB cleaves GSDME\"", "Reactome:R-HSA-976743 \"Factor I inactivates plasma Factor H-bound C3b\"", "Reactome:R-HSA-9769737 \"factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)\"", "Reactome:R-HSA-9769949 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage\"", "Reactome:R-HSA-9770187 \"S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion\"", "Reactome:R-HSA-977371 \"Factor I inactivates Factor H-boundC3b\"", "Reactome:R-HSA-977615 \"Factor I inactivates MCP/CR1-bound C4b/C3b\"", "Reactome:R-HSA-9816275 \"CDH1 is proteolytically cleaved in Golgi\"", "Reactome:R-HSA-9822513 \"TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)\"", "Reactome:R-HSA-9822514 \"TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-9822522 \"factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst)\"", "Reactome:R-HSA-9829030 \"Nascent F signal peptide is cleaved at ER membrane\"", "Reactome:R-HSA-9829200 \"F0 is cleaved, releasing F1, F2, F(110-136)\"", "Reactome:R-HSA-9830805 \"Nascent sG localizes to ER lumen, gets glycosylated\"", "Reactome:R-HSA-9830882 \"Nascent G signal peptide is cleaved at ER membrane\"", "Reactome:R-HSA-9839367 \"TGFBR3_mem cleavage by MMPs\"", "Reactome:R-HSA-9855735 \"factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)\"", "Reactome:R-HSA-9857814 \"prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)\"", "Reactome:R-HSA-9909046 \"kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)\"", "Reactome:R-HSA-9909048 \"prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst)\"", "Reactome:R-HSA-9911236 \"ELANE cleaves NOTCH2NLA\"", "Reactome:R-HSA-9911383 \"LepB cleaves prepro-STa\"", "Reactome:R-HSA-9912368 \"LepB cleaves pre-EltA\"", "Reactome:R-HSA-9912371 \"LepB cleaves pre-EltB\"", "Reactome:R-HSA-9913329 \"Autoproteolysis of DAG1 to alpha and beta chains\"", "Reactome:R-HSA-9918772 \"Dengue polyprotein cis-auto-cleaves\"", "Reactome:R-HSA-9918780 \"Unknown peptidase cleaves NS1-NS2A\"", "Reactome:R-HSA-9918787 \"NS2B3 cleaves C-prM-E-NS1-NS2A\"", "Reactome:R-HSA-9918795 \"Signalase cleaves prM-E-NS1-NS2A\"", "Reactome:R-HSA-9918813 \"NS2B3 cleaves NS4AB\"", "Reactome:R-HSA-9918817 \"NS2B3 cleaves polyprotein\"", "Reactome:R-HSA-9918823 \"NS345:NS2B cleaves NS345\"", "Reactome:R-HSA-9918871 \"Signalase cleaves prepro-NS4B\"", "Reactome:R-HSA-9918876 \"NS2B3 cleaves prepro-C at the C-prM junction\"", "Reactome:R-HSA-9919050 \"Furin cleaves prM:E\"", "Reactome:R-HSA-9921595 \"NS2B3 cleaves FAM134B\"", "Reactome:R-HSA-9921689 \"NS3 cleaves GrpEL1\"", "Reactome:R-HSA-9926936 \"EspC(54-1018) cleaves hemoglobin\"", "Reactome:R-HSA-9926963 \"Hbp cis-autocleaves\"", "Reactome:R-HSA-9927009 \"Hbp(53-1100) cleaves hemoglobin\"", "Reactome:R-HSA-9929051 \"TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-9929060 \"TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst)\"", "Reactome:R-HSA-9930440 \"F5 R334T, I387T is not cleaved by activated protein C\"", "Reactome:R-HSA-9930452 \"F5 R534Q, A540V is not cleaved by activated protein C\"", "Reactome:R-HSA-9930790 \"factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)\"", "Reactome:R-HSA-9930792 \"factor Va intermediate -> factor Va\"", "Reactome:R-HSA-9932162 \"Removal of CDH1 signal peptide\"", "Reactome:R-HSA-9936430 \"factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)\"", "Reactome:R-HSA-9936467 \"factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst)\"", "Reactome:R-HSA-9936906 \"factor XII:-amyloid:Zn2+-> factor XIIa + -amyloid:Zn2+ (autocatalysis)\"", "Reactome:R-HSA-9938539 \"kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin\"", "Reactome:R-HSA-9947496 \"ACOT2 cleaves NS345\"" ], "previous": [ "EC:3.4.21.-", "EC:3.4.21.1", "EC:3.4.21.10", "EC:3.4.21.102", "EC:3.4.21.20", "EC:3.4.21.21", "EC:3.4.21.22", "EC:3.4.21.26", "EC:3.4.21.27", "EC:3.4.21.34", "EC:3.4.21.35", "EC:3.4.21.36", "EC:3.4.21.38", "EC:3.4.21.39", "EC:3.4.21.4", "EC:3.4.21.41", "EC:3.4.21.42", "EC:3.4.21.43", "EC:3.4.21.45", "EC:3.4.21.46", "EC:3.4.21.47", "EC:3.4.21.48", "EC:3.4.21.5", "EC:3.4.21.53", "EC:3.4.21.54", "EC:3.4.21.59", "EC:3.4.21.6", "EC:3.4.21.61", "EC:3.4.21.62", "EC:3.4.21.68", "EC:3.4.21.69", "EC:3.4.21.7", "EC:3.4.21.71", "EC:3.4.21.73", "EC:3.4.21.75", "EC:3.4.21.78", "EC:3.4.21.79", "EC:3.4.21.83", "EC:3.4.21.88", "EC:3.4.21.9", "EC:3.4.21.92", "EC:3.4.21.93", "EC:3.4.21.94", "Reactome:R-HSA-114697 \"Activated thrombin (factor IIa) cleaves PAR3,4, activating them\"", "Reactome:R-HSA-1181152 \"Cleavage of NODAL proprotein\"", "Reactome:R-HSA-139893 \"Granzyme-B activates BID by cleavage\"", "Reactome:R-HSA-140599 \"factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides\"", "Reactome:R-HSA-140664 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)\"", "Reactome:R-HSA-140696 \"factor V -> factor Va + factor V activation peptide (thrombin catalyst)\"", "Reactome:R-HSA-140700 \"prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)\"", "Reactome:R-HSA-140736 \"factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140769 \"factor VII -> factor VIIa\"", "Reactome:R-HSA-140777 \"factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)\"", "Reactome:R-HSA-140823 \"factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)\"", "Reactome:R-HSA-140840 \"fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B\"", "Reactome:R-HSA-140870 \"thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin\"", "Reactome:R-HSA-141026 \"Activated protein C cleaves factor Va to factor Vi intermediate form\"", "Reactome:R-HSA-141040 \"Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C\"", "Reactome:R-HSA-1454843 \"E-cadherin degradation by MMP3, MMP7 and plasmin\"", "Reactome:R-HSA-1474197 \"Collagen type II degradation by MMP1,3,8,13,PRSS2\"", "Reactome:R-HSA-1566962 \"Elastin degradation by elastin-degrading extracellular proteinases\"", "Reactome:R-HSA-1566979 \"Laminin-332 degradation by laminin-322 degrading extracellular proteinases\"", "Reactome:R-HSA-1566981 \"Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS\"", "Reactome:R-HSA-158137 \"factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer\"", "Reactome:R-HSA-158164 \"factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)\"", "Reactome:R-HSA-158300 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)\"", "Reactome:R-HSA-158311 \"kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin\"", "Reactome:R-HSA-158313 \"factor XII -> factor XIIa\"", "Reactome:R-HSA-158333 \"factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)\"", "Reactome:R-HSA-158419 \"factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)\"", "Reactome:R-HSA-158744 \"crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin\"", "Reactome:R-HSA-158747 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)\"", "Reactome:R-HSA-158750 \"crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin\"", "Reactome:R-HSA-158766 \"fibrin multimer, crosslinked -> fibrin digestion products (plasmin)\"", "Reactome:R-HSA-158925 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)\"", "Reactome:R-HSA-158942 \"urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-158982 \"plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)\"", "Reactome:R-HSA-1592270 \"NID1 degradation by MMP1, 9, 12, ELANE\"", "Reactome:R-HSA-1592278 \"Autocatalytic activation of proMMP2\"", "Reactome:R-HSA-1592297 \"Full activation of MMP1\"", "Reactome:R-HSA-1592314 \"HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)\"", "Reactome:R-HSA-1592316 \"Initial activation of proMMP1\"", "Reactome:R-HSA-1592362 \"Activation of proMMP7 by MMP3\"", "Reactome:R-HSA-1592371 \"Initial activation of proMMP3\"", "Reactome:R-HSA-1592398 \"Activation of proMMP8\"", "Reactome:R-HSA-1592436 \"Initial activation of proMMP9 by MMPs\"", "Reactome:R-HSA-159728 \"Furin cleaves pro-prothrombin to prothrombin\"", "Reactome:R-HSA-159733 \"Furin cleaves pro-factor X to factor X\"", "Reactome:R-HSA-159771 \"Furin cleaves pro-protein C to protein C\"", "Reactome:R-HSA-159773 \"Furin cleaves pro-protein S to protein S\"", "Reactome:R-HSA-159796 \"Furin cleaves pro-factor IX to factor IX\"", "Reactome:R-HSA-159868 \"Furin cleaves pro-factor VII to factor VII\"", "Reactome:R-HSA-1602458 \"Activation of proMMP10\"", "Reactome:R-HSA-1602466 \"Activation of MT-MMPs by FURIN\"", "Reactome:R-HSA-1602473 \"Autocatalytic activation of MMP1\"", "Reactome:R-HSA-1602484 \"Activation of proMMP11 by FURIN\"", "Reactome:R-HSA-1602488 \"Initial activation of proMMP13 by plasmin and trypsin\"", "Reactome:R-HSA-1604359 \"Initial activation of proMMP2 by MMP1, 7\"", "Reactome:R-HSA-1604360 \"Initial activation of proMMP2 by MMP14\"", "Reactome:R-HSA-1604368 \"Autocatalytic activation of bound proMMP2\"", "Reactome:R-HSA-1604690 \"Activation of MMP9 intermediate form by MMPs\"", "Reactome:R-HSA-1604712 \"Initial activation of proMMP7 by trypsin\"", "Reactome:R-HSA-1604722 \"Activation of proMMP9 by proteases\"", "Reactome:R-HSA-1604731 \"Autocatalytic activation of MMP3\"", "Reactome:R-HSA-1604732 \"Autocatalytic activation of proMMP13\"", "Reactome:R-HSA-1604741 \"Initial activation of proMMP13 by MMP14 (MT1-MMP)\"", "Reactome:R-HSA-1604752 \"Initial activation of proMMP13 by MMP3\"", "Reactome:R-HSA-1604763 \"Autocatalytic activation of MMP7\"", "Reactome:R-HSA-163798 \"Furin cleaves pro-protein Z to protein Z\"", "Reactome:R-HSA-163843 \"Furin cleaves pro-GAS6 to GAS6\"", "Reactome:R-HSA-1655842 \"S1P hydrolyzes SREBP1A,1C,2\"", "Reactome:R-HSA-166753 \"Conversion of C4 into C4a and C4b\"", "Reactome:R-HSA-166792 \"Conversion of C2 into C2a and C2b\"", "Reactome:R-HSA-166817 \"Cleavage of C3 by C3 convertases\"", "Reactome:R-HSA-170844 \"Latent TGF-beta-1 is cleaved by FURIN\"", "Reactome:R-HSA-171288 \"Cleavage of the viral Env gp160 precursor polyprotein\"", "Reactome:R-HSA-173626 \"Activation of C1r\"", "Reactome:R-HSA-173631 \"Activation of C1s\"", "Reactome:R-HSA-173680 \"Activation of C5\"", "Reactome:R-HSA-173745 \"Factor D cleaves C3(H2O)-bound Factor B\"", "Reactome:R-HSA-174551 \"Formation of alternative pathway C5 convertase\"", "Reactome:R-HSA-1799329 \"Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein\"", "Reactome:R-HSA-183122 \"Factor D cleaves C3b-bound Factor B\"", "Reactome:R-HSA-183130 \"C3(H2O):Factor Bb cleaves C3 to C3b and C3a\"", "Reactome:R-HSA-186785 \"PDGF-AA clevage by Furin\"", "Reactome:R-HSA-187020 \"Part of pro-beta-NGF is processed to mature beta-NGF\"", "Reactome:R-HSA-1912369 \"NOTCH precursor cleaved to form mature NOTCH\"", "Reactome:R-HSA-1912372 \"Fringe-modified Pre-NOTCH is cleaved by FURIN\"", "Reactome:R-HSA-2022411 \"Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))\"", "Reactome:R-HSA-2129357 \"Fibrillin C-terminal processing\"", "Reactome:R-HSA-2168923 \"Collagen type XVIII endostatin release\"", "Reactome:R-HSA-2168960 \"Collagen type XVII ectodomain shedding\"", "Reactome:R-HSA-2172405 \"Collagen type XXIII ectodomain shedding\"", "Reactome:R-HSA-2214330 \"Cleavage of collagen VII NC2 region by BMP1\"", "Reactome:R-HSA-2471621 \"Endostatin degradation by cathepsins\"", "Reactome:R-HSA-2471842 \"Collagen type XXV ectomain shedding\"", "Reactome:R-HSA-2482180 \"Collagen type VIII degradation by ELANE\"", "Reactome:R-HSA-2514772 \"Fibrillin-1 degradation by MMP3, CTSK, CTSL2\"", "Reactome:R-HSA-2514823 \"Fibrillin-1 degradation by ELANE\"", "Reactome:R-HSA-2534160 \"HSPG2 (perlecan) degradation by MMP13, CTSS\"", "Reactome:R-HSA-2534206 \"E-cadherin degradation by PS1:NCSTN (Gamma-secretase)\"", "Reactome:R-HSA-2534260 \"E-cadherin degradation by caspase-3 and calpain-1\"", "Reactome:R-HSA-265301 \"Corticotropin cleavage from POMC\"", "Reactome:R-HSA-3244626 \"DENV protease NS2B3 cleaves STING\"", "Reactome:R-HSA-3266557 \"Factor I cleaves iC3b\"", "Reactome:R-HSA-3785684 \"Fibronectin degradation by CTSG\"", "Reactome:R-HSA-3788061 \"Fibronectin degradation by ADAM8\"", "Reactome:R-HSA-381135 \"MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)\"", "Reactome:R-HSA-381446 \"Thrombin proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381461 \"Plasmin proteolyzes IGF:IGFBP-3:ALS\"", "Reactome:R-HSA-381466 \"Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-3814820 \"HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1\"", "Reactome:R-HSA-381500 \"Cathepsin G proteolyzes IGF:IGFBP3:ALS\"", "Reactome:R-HSA-381798 \"PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1\"", "Reactome:R-HSA-382061 \"Extracellular processing of novel PDGFs\"", "Reactome:R-HSA-3928657 \"MMP2,9 cleave EPHB\"", "Reactome:R-HSA-400459 \"Signal peptidase hydrolyzes preproGLP-1 to proGLP-1\"", "Reactome:R-HSA-400492 \"PCSK1 hydrolyzes proGIP to GIP\"", "Reactome:R-HSA-400496 \"Signal peptidase hydrolyzes preproGIP to proGIP\"", "Reactome:R-HSA-422021 \"PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin\"", "Reactome:R-HSA-422051 \"Cleavage of the signal peptide of Preproghrelin\"", "Reactome:R-HSA-5210912 \"Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5210935 \"Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)\"", "Reactome:R-HSA-5578783 \"CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)\"", "Reactome:R-HSA-5591040 \"Activated protein C cleaves Factor Va intermediate form for Factor Va\"", "Reactome:R-HSA-5607002 \"Activated protein C cleaves factor VIIIa\"", "Reactome:R-HSA-5691512 \"APEH hydrolyses NAc-Ser-protein\"", "Reactome:R-HSA-6800198 \"HPN heterodimer cleaves pro-MST1 to form MST1 dimer\"", "Reactome:R-HSA-6800200 \"HPN heterodimer cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6800299 \"HGFAC cleaves pro-HGF to form HGF dimer\"", "Reactome:R-HSA-6801687 \"PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)\"", "Reactome:R-HSA-6807224 \"Furin cleaves pro-BGLAP to BGLAP\"", "Reactome:R-HSA-8849826 \"ST14 hydrolyzes and activates KLK5\"", "Reactome:R-HSA-8849857 \"KLK5 cleaves and activates CELA2\"", "Reactome:R-HSA-8850831 \"KLK5 cleaves and activates KLK8\"", "Reactome:R-HSA-8852716 \"Thrombin, ELANE cleave C5\"", "Reactome:R-HSA-8855825 \"HTRA1 hydrolyzes ACAN (Aggrecan)\"", "Reactome:R-HSA-8865275 \"PDGF-BB clevage by Furin\"", "Reactome:R-HSA-8865276 \"PDGF-AB clevage by Furin\"", "Reactome:R-HSA-8874145 \"MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)\"", "Reactome:R-HSA-8874186 \"MBTPS1 (S1P) cleaves CREB3L4\"", "Reactome:R-HSA-8874204 \"MBTPS1 (S1P) cleaves CREB3\"", "Reactome:R-HSA-8874205 \"MBTPS1 (S1P) cleaves CREB3L2\"", "Reactome:R-HSA-8874206 \"MBTPS1 (S1P) cleaves CREB3L3\"", "Reactome:R-HSA-8874212 \"MBTPS1 (S1P) cleaves CREB3L1\"", "Reactome:R-HSA-9023178 \"PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))\"", "Reactome:R-HSA-9023196 \"PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)\"", "Reactome:R-HSA-9023626 \"DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023627 \"DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)\"", "Reactome:R-HSA-9023632 \"DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9023633 \"DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)\"", "Reactome:R-HSA-9033490 \"TYSND1 cleaves PHYH\"", "Reactome:R-HSA-9033506 \"TYSND1 cleaves AGPS\"", "Reactome:R-HSA-9033515 \"TYSND1 cleaves ACOX1\"", "Reactome:R-HSA-9033520 \"TYSND1 cleaves TYSND1\"", "Reactome:R-HSA-9033524 \"TYSND1 cleaves SCP2\"", "Reactome:R-HSA-9033529 \"TYSND1 cleaves ACAA1\"", "Reactome:R-HSA-9033530 \"TYSND1 cleaves HSD17B4\"", "Reactome:R-HSA-9653249 \"Cleavage of factor XII variant by activated thrombin\"", "Reactome:R-HSA-9655046 \"Cleavage of FXII variant by KLKB1\"", "Reactome:R-HSA-9662786 \"FURIN cleaves ADAM17\"", "Reactome:R-HSA-9666383 \"F8 variant is not cleaved by thrombin\"", "Reactome:R-HSA-9668253 \"Hyperactivation of factor X by FVIIIa:FIXa R384L\"", "Reactome:R-HSA-9668365 \"FVIIIa variant:FIXa does not convert FX to the active FXa\"", "Reactome:R-HSA-9670874 \"FIXa variant:FVIIIa does not convert FX to the active FXa\"", "Reactome:R-HSA-9673223 \"FIX(29-461) variant is not activated (factor XIa catalyst)\"", "Reactome:R-HSA-9686710 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9686731 \"TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9694287 \"Cleavage of S protein into S1:S2\"", "Reactome:R-HSA-9694661 \"TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9698988 \"Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid\"", "Reactome:R-HSA-9699007 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis\"", "Reactome:R-HSA-9708859 \"Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it\"", "Reactome:R-HSA-9710106 \"ELANE cleaves GSDMD\"", "Reactome:R-HSA-9710263 \"GZMB cleaves GSDME\"", "Reactome:R-HSA-976743 \"Factor I inactivates plasma Factor H-bound C3b\"", "Reactome:R-HSA-9769949 \"FURIN Mediated SARS-CoV-2 Spike Protein Cleavage\"", "Reactome:R-HSA-9770187 \"S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion\"", "Reactome:R-HSA-977371 \"Factor I inactivates Factor H-boundC3b\"", "Reactome:R-HSA-977615 \"Factor I inactivates MCP/CR1-bound C4b/C3b\"", "Reactome:R-HSA-9816275 \"CDH1 is proteolytically cleaved in Golgi\"", "Reactome:R-HSA-9829030 \"Nascent F signal peptide is cleaved at ER membrane\"", "Reactome:R-HSA-9829200 \"F0 is cleaved, releasing F1, F2, F(110-136)\"", "Reactome:R-HSA-9830805 \"Nascent sG localizes to ER lumen, gets glycosylated\"", "Reactome:R-HSA-9830882 \"Nascent G signal peptide is cleaved at ER membrane\"", "Reactome:R-HSA-9839367 \"TGFBR3_mem cleavage by MMPs\"", "Reactome:R-HSA-9911236 \"ELANE cleaves NOTCH2NLA\"", "Reactome:R-HSA-9911383 \"LepB cleaves prepro-STa\"", "Reactome:R-HSA-9912368 \"LepB cleaves pre-EltA\"", "Reactome:R-HSA-9912371 \"LepB cleaves pre-EltB\"", "Reactome:R-HSA-9913329 \"Autoproteolysis of DAG1 to alpha and beta chains\"", "Reactome:R-HSA-9918772 \"Dengue polyprotein cis-auto-cleaves\"", "Reactome:R-HSA-9918780 \"Unknown peptidase cleaves NS1-NS2A\"", "Reactome:R-HSA-9918787 \"NS2B3 cleaves C-prM-E-NS1-NS2A\"", "Reactome:R-HSA-9918795 \"Signalase cleaves prM-E-NS1-NS2A\"", "Reactome:R-HSA-9918813 \"NS2B3 cleaves NS4AB\"", "Reactome:R-HSA-9918817 \"NS2B3 cleaves polyprotein\"", "Reactome:R-HSA-9918823 \"NS345:NS2B cleaves NS345\"", "Reactome:R-HSA-9918871 \"Signalase cleaves prepro-NS4B\"", "Reactome:R-HSA-9918876 \"NS2B3 cleaves prepro-C at the C-prM junction\"", "Reactome:R-HSA-9919050 \"Furin cleaves prM:E\"", "Reactome:R-HSA-9921595 \"NS2B3 cleaves FAM134B\"", "Reactome:R-HSA-9921689 \"NS3 cleaves GrpEL1\"", "Reactome:R-HSA-9926936 \"EspC(54-1018) cleaves hemoglobin\"", "Reactome:R-HSA-9926963 \"Hbp cis-autocleaves\"", "Reactome:R-HSA-9927009 \"Hbp(53-1100) cleaves hemoglobin\"", "Reactome:R-HSA-9932162 \"Removal of CDH1 signal peptide\"", "Reactome:R-HSA-9947496 \"ACOT2 cleaves NS345\"" ] } } }, { "id": "GO:0004300", "name": "enoyl-CoA hydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.17", "Reactome:R-HSA-70830 \"tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA\"", "Reactome:R-HSA-70870 \"ECHS1 hydrates methacrylyl-CoA\"", "Reactome:R-HSA-77256 \"2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA\"", "Reactome:R-HSA-77277 \"trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoA\"", "Reactome:R-HSA-77301 \"trans-Hexadec-2-enoyl-CoA+H2O => (S)-3-Hydroxyhexadecanoyl-CoA\"", "Reactome:R-HSA-77314 \"Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA\"", "Reactome:R-HSA-77325 \"trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA\"", "Reactome:R-HSA-77333 \"trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA\"", "Reactome:R-HSA-77344 \"trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA\"", "Reactome:R-HSA-9916717 \"ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA\"", "RHEA:20724" ], "previous": [ "EC:4.2.1.17", "Reactome:R-HSA-70830 \"tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA\"", "Reactome:R-HSA-70870 \"ECHS1 hydrates methacrylyl-CoA\"", "Reactome:R-HSA-77256 \"2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA\"", "Reactome:R-HSA-77277 \"trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA\"", "Reactome:R-HSA-77301 \"trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA\"", "Reactome:R-HSA-77314 \"Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA\"", "Reactome:R-HSA-77325 \"trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA\"", "Reactome:R-HSA-77333 \"trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA\"", "Reactome:R-HSA-77344 \"trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA\"", "Reactome:R-HSA-9916717 \"ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA\"", "RHEA:20724" ] } } }, { "id": "GO:0004301", "name": "epoxide hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.3.2.10", "MetaCyc:3.3.2.10-RXN", "Reactome:R-HSA-2161961 \"5,6-EET is hydrolysed to 5,6-DHET by EPHX2\"", "Reactome:R-HSA-9018862 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1\"", "Reactome:R-HSA-9018877 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1\"", "Reactome:R-HSA-9020252 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2\"", "Reactome:R-HSA-9020253 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4\"", "Reactome:R-HSA-9020257 \"LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1\"", "Reactome:R-HSA-9020258 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2\"", "Reactome:R-HSA-9020270 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4\"", "Reactome:R-HSA-9024890 \"LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1\"", "Reactome:R-HSA-9024973 \"Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1\"", "Reactome:R-HSA-9024993 \"EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2\"", "Reactome:R-HSA-9025998 \"Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA\"", "Reactome:R-HSA-9026000 \"Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA\"", "Reactome:R-HSA-9026008 \"Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA\"", "Reactome:R-HSA-9915968 \"8,9-EET is hydrolysed to 8.9-DHET by EPHX2\"", "Reactome:R-HSA-9915986 \"11,12-EET is hydrolysed to 11,12-DHET by EPHX2\"", "Reactome:R-HSA-9915994 \"14,15-EET is hydrolysed to 14,15-DHET by EPHX2\"", "RHEA:19037", "RHEA:44032", "RHEA:44036", "RHEA:44040", "RHEA:44044", "RHEA:44048", "RHEA:45352", "RHEA:53972", "RHEA:53976", "RHEA:53980", "RHEA:53984", "RHEA:53992", "RHEA:53996", "RHEA:54000", "RHEA:54004", "RHEA:54008", "RHEA:54012", "RHEA:54016", "RHEA:56584", "RHEA:80591", "RHEA:80779", "RHEA:80783", "RHEA:80787", "RHEA:80791", "RHEA:80795", "RHEA:80799", "RHEA:81855" ], "previous": [ "EC:3.3.2.10", "MetaCyc:3.3.2.10-RXN", "Reactome:R-HSA-2161961 \"5,6-EET is hydrolysed to 5,6-DHET by EPHX2\"", "Reactome:R-HSA-9018862 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1\"", "Reactome:R-HSA-9018877 \"LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1\"", "Reactome:R-HSA-9020252 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2\"", "Reactome:R-HSA-9020253 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4\"", "Reactome:R-HSA-9020257 \"LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1\"", "Reactome:R-HSA-9020258 \"LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2\"", "Reactome:R-HSA-9020270 \"LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4\"", "Reactome:R-HSA-9024890 \"LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1\"", "Reactome:R-HSA-9024973 \"Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1\"", "Reactome:R-HSA-9024993 \"EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2\"", "Reactome:R-HSA-9025998 \"Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA\"", "Reactome:R-HSA-9026000 \"Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA\"", "Reactome:R-HSA-9026008 \"Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA\"", "Reactome:R-HSA-9915968 \"8,9-EET is hydrolysed to 8.9-DHET by EPHX2\"", "Reactome:R-HSA-9915986 \"11,12-EET is hydrolysed to 11,12-DHET by EPHX2\"", "Reactome:R-HSA-9915994 \"14,15-EET is hydrolysed to 14,15-DHET by EPHX2\"", "RHEA:19037", "RHEA:44032", "RHEA:44036", "RHEA:44040", "RHEA:44044", "RHEA:44048", "RHEA:45352", "RHEA:56584", "RHEA:80591", "RHEA:80779", "RHEA:80783", "RHEA:80787", "RHEA:80791", "RHEA:80795", "RHEA:80799", "RHEA:81855" ] } } }, { "id": "GO:0004368", "name": "glycerol-3-phosphate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.1.5.3", "MetaCyc:RXN-15745", "Reactome:R-HSA-188467 \"Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)\"", "RHEA:18977", "RHEA:28751", "RHEA:28755", "RHEA:29219", "RHEA:29223" ], "previous": [ "EC:1.1.5.3", "MetaCyc:RXN-15745", "Reactome:R-HSA-188467 \"Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)\"", "RHEA:18977", "RHEA:28755", "RHEA:29219" ] } } }, { "id": "GO:0004407", "name": "histone deacetylase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2545203 \"Deacetylation of cleaved cohesin\"", "Reactome:R-HSA-2545253 \"Deacetylation of cohesin\"", "Reactome:R-HSA-3769447 \"HDAC1:2-containing complex deacetylate histones\"", "Reactome:R-HSA-3777129 \"HDAC3 containing complexes deacetylate histone\"", "Reactome:R-HSA-3782637 \"HDAC8 deacetylates histones\"", "Reactome:R-HSA-3782655 \"HDAC10 deacetylates histone\"", "Reactome:R-HSA-427514 \"eNoSC deacetylates histone H3\"", "Reactome:R-HSA-433672 \"NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3\"", "Reactome:R-HSA-6805650 \"MTA2-NuRD complex deacetylates TP53\"", "Reactome:R-HSA-9941704 \"NuRD deacetylates telomeric nucleosomes\"", "Reactome:R-HSA-9944092 \"NuRD deacetylates nucleosomes\"" ], "previous": [ "Reactome:R-HSA-2545203 \"Deacetylation of cleaved cohesin\"", "Reactome:R-HSA-2545253 \"Deacetylation of cohesin\"", "Reactome:R-HSA-3769447 \"HDAC1:2-containing complex deacetylate histones\"", "Reactome:R-HSA-3777129 \"HDAC3 containing complexes deacetylate histone\"", "Reactome:R-HSA-3782637 \"HDAC8 deacetylates histones\"", "Reactome:R-HSA-3782655 \"HDAC10 deacetylates histone\"", "Reactome:R-HSA-427514 \"eNoSC deacetylates histone H3\"", "Reactome:R-HSA-433672 \"NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3\"", "Reactome:R-HSA-6805650 \"MTA2-NuRD complex deacetylates TP53\"" ] } } }, { "id": "GO:0004483", "name": "methyltransferase cap1 activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.57", "MetaCyc:2.1.1.57-RXN", "Reactome:R-HSA-9684030 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9684032 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684033 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9694499 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694521 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694721 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"", "Reactome:R-HSA-9834003 \"L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs\"", "Reactome:R-HSA-9923097 \"NS5 acts as a cap 2'-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA\"", "RHEA:19617", "RHEA:60860", "RHEA:60864", "RHEA:67020" ], "previous": [ "EC:2.1.1.57", "MetaCyc:2.1.1.57-RXN", "Reactome:R-HSA-9684030 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)\"", "Reactome:R-HSA-9684032 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)\"", "Reactome:R-HSA-9684033 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs\"", "Reactome:R-HSA-9694499 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs\"", "Reactome:R-HSA-9694521 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)\"", "Reactome:R-HSA-9694721 \"nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)\"", "Reactome:R-HSA-9834003 \"L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs\"", "Reactome:R-HSA-9923097 \"NS5 acts as a cap 2'-O-methyltransferase to methylate 5 m7GpppA of DENV genomic +ssRNA\"", "RHEA:67020" ] } } }, { "id": "GO:0004491", "name": "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "changes": { "xrefs": { "current": [ "EC:1.2.1.27", "MetaCyc:1.2.1.27-RXN", "Reactome:R-HSA-70893 \"methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+\"", "RHEA:20804", "RHEA:76615", "RHEA:76623", "RHEA:76627" ], "previous": [ "EC:1.2.1.27", "MetaCyc:1.2.1.27-RXN", "Reactome:R-HSA-70893 \"methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+\"", "RHEA:20804", "RHEA:76615" ] } } }, { "id": "GO:0004497", "name": "monooxygenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-143468 \"MEOS oxidizes ethanol to acetaldehyde\"", "Reactome:R-HSA-156526 \"CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-211882 \"CYP3A7 can 6beta-hydroxylate testosterone\"", "Reactome:R-HSA-211904 \"CYP4F12 18-hydroxylates ARA\"", "Reactome:R-HSA-211910 \"CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation\"", "Reactome:R-HSA-211919 \"CYP4F8 19-hydroxylates PGH2\"", "Reactome:R-HSA-211924 \"CYP4B1 12-hydroxylates ARA\"", "Reactome:R-HSA-211929 \"CYP2C19 5-hydroxylates omeprazole\"", "Reactome:R-HSA-211948 \"CYP3A4 can N-demethylate loperamide\"", "Reactome:R-HSA-211959 \"CYP3A43 6b-hydroxylates TEST\"", "Reactome:R-HSA-211960 \"CYP2U1 19-hydroxylates ARA\"", "Reactome:R-HSA-211962 \"CYP4F11 16-hydroxylates 3OH-PALM\"", "Reactome:R-HSA-211968 \"CYP2W1 oxidises INDOL\"", "Reactome:R-HSA-211988 \"CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation\"", "Reactome:R-HSA-211991 \"Cyclophosphamide is 4-hydroxylated by CYP2B6\"", "Reactome:R-HSA-212004 \"CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation\"", "Reactome:R-HSA-212005 \"CYP2F1 dehydrogenates 3-methylindole\"", "Reactome:R-HSA-213175 \"CYP3A4,5 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-215526 \"CYP4F3 20-hydroxylates LTB4\"", "Reactome:R-HSA-2161795 \"Arachidonate is hydroxylated to 16-HETE by CYP(1)\"", "Reactome:R-HSA-2161814 \"Arachidonate is hydroxylated to 19-HETE by CYP(2)\"", "Reactome:R-HSA-2161890 \"Arachidonate is epoxidated to 5,6-EET by CYP(4)\"", "Reactome:R-HSA-2161899 \"Arachidonate is epoxidated to 8,9-EET by CYP(5)\"", "Reactome:R-HSA-2161940 \"Arachidonate is hydroxylated to 20-HETE by CYP(3)\"", "Reactome:R-HSA-2162191 \"Unknown enzyme hydroxylates DMPhOH\"", "Reactome:R-HSA-217258 \"FMO2:FAD:Mg2+ S-oxidises MTZ\"", "Reactome:R-HSA-5423647 \"CYP2A13 oxidises AFM1 to AFM1E\"", "Reactome:R-HSA-5423664 \"CYP3A4,5 hydroxylates AFB1 to AFQ1\"", "Reactome:R-HSA-5423672 \"CYP1A2, 3A4 oxidise AFB1 to AFNBO\"", "Reactome:R-HSA-5423678 \"CYP1A2 hydroxylates AFB1 to AFM1\"", "Reactome:R-HSA-5602242 \"Defective CYP2U1 does not omega-hydroxylate ARA\"", "Reactome:R-HSA-5602272 \"Defective CYP4F22 does not 20-hydroxylate TrXA3\"", "Reactome:R-HSA-5602295 \"CYP4F22 20-hydroxylates TrXA3\"", "Reactome:R-HSA-5605147 \"Defective CYP1B1 does not 4-hydroxylate EST17b\"", "Reactome:R-HSA-76354 \"Vinyl chloride is oxidized to 2-Chloroethylene oxide\"", "Reactome:R-HSA-76373 \"N-hydroxylation of 4-aminobiphenyl\"", "Reactome:R-HSA-76386 \"CYP1A2 S-demethylates 6MMP\"", "Reactome:R-HSA-76397 \"Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)\"", "Reactome:R-HSA-76416 \"Benzene is hydroxylated to phenol\"", "Reactome:R-HSA-76426 \"N-atom dealkylation of caffeine\"", "Reactome:R-HSA-76434 \"Dehalogenation of carbon tetrachloride to form a free radical\"", "Reactome:R-HSA-76456 \"O-atom dealkylation of dextromethorphan\"", "Reactome:R-HSA-76466 \"CYP4A11 omega-hydroxylates DDCX\"", "Reactome:R-HSA-76472 \"Ethylene is oxidized to Ethylene oxide by CYP1A1\"", "Reactome:R-HSA-76475 \"Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide\"", "Reactome:R-HSA-8865107 \"MICAL1 produces NADP+, H2O2\"", "Reactome:R-HSA-9018874 \"CYP monooxygenates EPA to 18(S)-HpEPE\"", "Reactome:R-HSA-9027042 \"CPY4 -oxidises 14(S)-HDHA to MaR-L1\"", "Reactome:R-HSA-9027043 \"CYPs hydroxylate DHA to 14(R)-HDHA\"", "Reactome:R-HSA-9027044 \"CYP4 -oxidises 14(R)-HDHA to MaR-L2\"", "Reactome:R-HSA-9027302 \"CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA\"", "Reactome:R-HSA-9027321 \"CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA\"", "Reactome:R-HSA-9037761 \"CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1\"", "Reactome:R-HSA-9749986 \"CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA\"", "Reactome:R-HSA-9750016 \"CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA\"", "Reactome:R-HSA-9753285 \"CYP2E1 monooxygenates APAP to NAPQI\"", "Reactome:R-HSA-9756138 \"CYP3A4 monooxygenates ATVL to 2-OH-ATVL\"", "Reactome:R-HSA-9756162 \"CYP3A4 monooxygenates ATV to 4-OH-ATV\"", "Reactome:R-HSA-9756169 \"CYP3A4 monooxygenates ATV to 2-OH-ATV\"", "Reactome:R-HSA-9756180 \"CYP3A4 monooxygenates ATVL to 4-OH-ATVL\"", "Reactome:R-HSA-9915971 \"Arachidonate is epoxidated to 11,12-EET by CYP(5)\"", "Reactome:R-HSA-9915992 \"Arachidonate is hydroxylated to 17-HETE by CYP(1)\"", "Reactome:R-HSA-9915993 \"Arachidonate is hydroxylated to 18-HETE by CYP(1)\"", "Reactome:R-HSA-9915997 \"Arachidonate is epoxidated to 14,15-EET by CYP(5)\"", "Reactome:R-HSA-9971246 \"Unknown CYP 450 omega-hydroxylates C10 fatty acid\"" ], "previous": [ "Reactome:R-HSA-143468 \"MEOS oxidizes ethanol to acetaldehyde\"", "Reactome:R-HSA-156526 \"CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-211882 \"CYP3A7 can 6beta-hydroxylate testosterone\"", "Reactome:R-HSA-211904 \"CYP4F12 18-hydroxylates ARA\"", "Reactome:R-HSA-211910 \"CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation\"", "Reactome:R-HSA-211919 \"CYP4F8 19-hydroxylates PGH2\"", "Reactome:R-HSA-211924 \"CYP4B1 12-hydroxylates ARA\"", "Reactome:R-HSA-211929 \"CYP2C19 5-hydroxylates omeprazole\"", "Reactome:R-HSA-211948 \"CYP3A4 can N-demethylate loperamide\"", "Reactome:R-HSA-211959 \"CYP3A43 6b-hydroxylates TEST\"", "Reactome:R-HSA-211960 \"CYP2U1 19-hydroxylates ARA\"", "Reactome:R-HSA-211962 \"CYP4F11 16-hydroxylates 3OH-PALM\"", "Reactome:R-HSA-211968 \"CYP2W1 oxidises INDOL\"", "Reactome:R-HSA-211988 \"CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation\"", "Reactome:R-HSA-211991 \"Cyclophosphamide is 4-hydroxylated by CYP2B6\"", "Reactome:R-HSA-212004 \"CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation\"", "Reactome:R-HSA-212005 \"CYP2F1 dehydrogenates 3-methylindole\"", "Reactome:R-HSA-213175 \"CYP3A4,5 oxidise AFB1 to AFXBO\"", "Reactome:R-HSA-215526 \"CYP4F3 20-hydroxylates LTB4\"", "Reactome:R-HSA-2161795 \"Arachidonate is hydroxylated to 16-HETE by CYP(1)\"", "Reactome:R-HSA-2161814 \"Arachidonate is hydroxylated to 19-HETE by CYP(2)\"", "Reactome:R-HSA-2161890 \"Arachidonate is epoxidated to 5,6-EET by CYP(4)\"", "Reactome:R-HSA-2161899 \"Arachidonate is epoxidated to 8,9-EET by CYP(5)\"", "Reactome:R-HSA-2161940 \"Arachidonate is hydroxylated to 20-HETE by CYP(3)\"", "Reactome:R-HSA-2162191 \"Unknown enzyme hydroxylates DMPhOH\"", "Reactome:R-HSA-217258 \"FMO2:FAD:Mg2+ S-oxidises MTZ\"", "Reactome:R-HSA-5423647 \"CYP2A13 oxidises AFM1 to AFM1E\"", "Reactome:R-HSA-5423664 \"CYP3A4,5 hydroxylates AFB1 to AFQ1\"", "Reactome:R-HSA-5423672 \"CYP1A2, 3A4 oxidise AFB1 to AFNBO\"", "Reactome:R-HSA-5423678 \"CYP1A2 hydroxylates AFB1 to AFM1\"", "Reactome:R-HSA-5602242 \"Defective CYP2U1 does not omega-hydroxylate ARA\"", "Reactome:R-HSA-5602272 \"Defective CYP4F22 does not 20-hydroxylate TrXA3\"", "Reactome:R-HSA-5602295 \"CYP4F22 20-hydroxylates TrXA3\"", "Reactome:R-HSA-5605147 \"Defective CYP1B1 does not 4-hydroxylate EST17b\"", "Reactome:R-HSA-76354 \"Vinyl chloride is oxidized to 2-Chloroethylene oxide\"", "Reactome:R-HSA-76373 \"N-hydroxylation of 4-aminobiphenyl\"", "Reactome:R-HSA-76386 \"CYP1A2 S-demethylates 6MMP\"", "Reactome:R-HSA-76397 \"Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)\"", "Reactome:R-HSA-76416 \"Benzene is hydroxylated to phenol\"", "Reactome:R-HSA-76426 \"N-atom dealkylation of caffeine\"", "Reactome:R-HSA-76434 \"Dehalogenation of carbon tetrachloride to form a free radical\"", "Reactome:R-HSA-76456 \"O-atom dealkylation of dextromethorphan\"", "Reactome:R-HSA-76466 \"CYP4A11 omega-hydroxylates DDCX\"", "Reactome:R-HSA-76472 \"Ethylene is oxidized to Ethylene oxide by CYP1A1\"", "Reactome:R-HSA-76475 \"Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide\"", "Reactome:R-HSA-8865107 \"MICAL1 produces NADP+, H2O2\"", "Reactome:R-HSA-9018874 \"CYP monooxygenates EPA to 18(S)-HpEPE\"", "Reactome:R-HSA-9027042 \"CPY4 -oxidises 14(S)-HDHA to MaR-L1\"", "Reactome:R-HSA-9027043 \"CYPs hydroxylate DHA to 14(R)-HDHA\"", "Reactome:R-HSA-9027044 \"CYP4 -oxidises 14(R)-HDHA to MaR-L2\"", "Reactome:R-HSA-9027302 \"CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA\"", "Reactome:R-HSA-9027321 \"CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA\"", "Reactome:R-HSA-9037761 \"CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1\"", "Reactome:R-HSA-9749986 \"CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA\"", "Reactome:R-HSA-9750016 \"CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA\"", "Reactome:R-HSA-9753285 \"CYP2E1 monooxygenates APAP to NAPQI\"", "Reactome:R-HSA-9756138 \"CYP3A4 monooxygenates ATVL to 2-OH-ATVL\"", "Reactome:R-HSA-9756162 \"CYP3A4 monooxygenates ATV to 4-OH-ATV\"", "Reactome:R-HSA-9756169 \"CYP3A4 monooxygenates ATV to 2-OH-ATV\"", "Reactome:R-HSA-9756180 \"CYP3A4 monooxygenates ATVL to 4-OH-ATVL\"", "Reactome:R-HSA-9915971 \"Arachidonate is epoxidated to 11,12-EET by CYP(5)\"", "Reactome:R-HSA-9915992 \"Arachidonate is hydroxylated to 17-HETE by CYP(1)\"", "Reactome:R-HSA-9915993 \"Arachidonate is hydroxylated to 18-HETE by CYP(1)\"", "Reactome:R-HSA-9915997 \"Arachidonate is epoxidated to 14,15-EET by CYP(5)\"" ] } } }, { "id": "GO:0004519", "name": "endonuclease activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5358512 \"MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more\"", "Reactome:R-HSA-5358518 \"MLH1:PMS2 makes single strand incision near 1-2 base mismatch\"", "Reactome:R-HSA-5690990 \"5'- incision of DNA by ERCC1:ERCC4 in GG-NER\"", "Reactome:R-HSA-5693533 \"DCLRE1C (ARTEMIS) processes DNA DSB ends\"", "Reactome:R-HSA-9970193 \"CPSF3 cleaves pre-mRNA at distal 3'UTR PAS\"", "Reactome:R-HSA-9970282 \"U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS\"", "Reactome:R-HSA-9970294 \"CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS\"" ], "previous": [ "Reactome:R-HSA-5358512 \"MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more\"", "Reactome:R-HSA-5358518 \"MLH1:PMS2 makes single strand incision near 1-2 base mismatch\"", "Reactome:R-HSA-5690990 \"5'- incision of DNA by ERCC1:ERCC4 in GG-NER\"", "Reactome:R-HSA-5693533 \"DCLRE1C (ARTEMIS) processes DNA DSB ends\"", "Reactome:R-HSA-72180 \"Cleavage of mRNA at the 3'-end\"", "Reactome:R-HSA-9970193 \"CPSF3 cleaves pre-mRNA at distal 3'UTR PAS\"", "Reactome:R-HSA-9970282 \"U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS\"", "Reactome:R-HSA-9970294 \"CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS\"" ] } } }, { "id": "GO:0004550", "name": "nucleoside diphosphate kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.4.6", "MetaCyc:NUCLEOSIDE-DIP-KIN-RXN", "Reactome:R-HSA-2162096 \"carbovir diphosphate + ATP => carbovir triphosphate + ADP\"", "Reactome:R-HSA-482619 \"(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)\"", "Reactome:R-HSA-482621 \"(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)\"", "Reactome:R-HSA-482804 \"(d)NDP + ATP <=> (d)NTP + ADP (NME4)\"", "Reactome:R-HSA-482812 \"(d)NTP + ADP <=> (d)NDP + ATP (NME4)\"", "Reactome:R-HSA-6806877 \"NME1:NME3 heterohexamer phosphorylates NDPs to NTPs\"", "Reactome:R-HSA-9605496 \"NME6 phosphorylates (d)NDPs to (d)NTPs\"", "Reactome:R-HSA-9748969 \"NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP\"", "Reactome:R-HSA-9748999 \"NME1:2 hexamer phosphorylates 6TGDP to 6TGTP\"", "Reactome:R-HSA-9755013 \"NME1,2 hexamers phosphorylate RBV-DP\"" ], "previous": [ "EC:2.7.4.6", "MetaCyc:NUCLEOSIDE-DIP-KIN-RXN", "Reactome:R-HSA-2162096 \"carbovir diphosphate + ATP => carbovir triphosphate + ADP\"", "Reactome:R-HSA-482619 \"(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)\"", "Reactome:R-HSA-482621 \"(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)\"", "Reactome:R-HSA-482804 \"(d)NDP + ATP <=> (d)NTP + ADP (NME4)\"", "Reactome:R-HSA-482812 \"(d)NTP + ADP <=> (d)NDP + ATP (NME4)\"", "Reactome:R-HSA-6806877 \"NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs\"", "Reactome:R-HSA-9748969 \"NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP\"", "Reactome:R-HSA-9748999 \"NME1:2 hexamer phosphorylates 6TGDP to 6TGTP\"", "Reactome:R-HSA-9755013 \"NME1,2 hexamers phosphorylate RBV-DP\"" ] } } }, { "id": "GO:0004596", "name": "protein-N-terminal amino-acid acetyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.255", "Reactome:R-HSA-6814090 \"NatC acetylates ARFFRP1\"", "RHEA:21028", "RHEA:50508", "RHEA:50512", "RHEA:50516", "RHEA:57320", "RHEA:57324", "RHEA:57328", "RHEA:75243", "RHEA:75247" ], "previous": [ "EC:2.3.1.255", "Reactome:R-HSA-6814090 \"NatC acetylates ARFFRP1\"", "RHEA:21028", "RHEA:50508", "RHEA:50512", "RHEA:50516", "RHEA:57320", "RHEA:75243", "RHEA:75247" ] } } }, { "id": "GO:0004607", "name": "phosphatidylcholine-sterol O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.43", "MetaCyc:2.3.1.43-RXN", "Reactome:R-HSA-264695 \"cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)\"", "RHEA:21204", "RHEA:34087", "RHEA:53448", "RHEA:53452", "RHEA:53456", "RHEA:53460", "RHEA:53464", "RHEA:53468", "RHEA:53472", "RHEA:53476", "RHEA:53516", "RHEA:53520" ], "previous": [ "EC:2.3.1.43", "MetaCyc:2.3.1.43-RXN", "Reactome:R-HSA-264695 \"cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)\"", "RHEA:21204", "RHEA:34087" ] } } }, { "id": "GO:0004623", "name": "A2-type glycerophospholipase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.4", "MetaCyc:PHOSPHOLIPASE-A2-RXN", "MetaCyc:RXN-15065", "MetaCyc:RXN-15067", "Reactome:R-HSA-111881 \"Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase\"", "Reactome:R-HSA-111883 \"PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine\"", "Reactome:R-HSA-1482604 \"PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)\"", "Reactome:R-HSA-1482656 \"PA is hydrolysed to 1-acyl LPA by PLA2[1]\"", "Reactome:R-HSA-1482679 \"PA is hydrolysed to 1-acyl LPA by PLA2G2A\"", "Reactome:R-HSA-1482745 \"PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)\"", "Reactome:R-HSA-1482759 \"MLCL is hydrolyzed to DLCL by PLA2G4A (IM)\"", "Reactome:R-HSA-1482771 \"PS is hydrolyzed to 1-acyl LPS by PLA2[9]\"", "Reactome:R-HSA-1482776 \"PS is hydrolyzed to 1-acyl LPS by PLA2G2A\"", "Reactome:R-HSA-1482778 \"CL is hydrolyzed to MLCL by PLA2G6 (IM)\"", "Reactome:R-HSA-1482816 \"PC is hydrolyzed to 1-acyl LPC by PLA2[6]\"", "Reactome:R-HSA-1482825 \"PI is hydrolyzed to 1-acyl LPI by PLA2[11]\"", "Reactome:R-HSA-1482856 \"PC is hydrolyzed to 1-acyl LPC by PLA2[5]\"", "Reactome:R-HSA-1482868 \"PI is hydrolyzed to 1-acyl LPI by PLA2[12]\"", "Reactome:R-HSA-1482884 \"PE is hydrolyzed to 1-acyl LPE by PLA2[2]\"", "Reactome:R-HSA-1482887 \"PE is hydrolyzed to 1-acyl LPE by PLA2[3]\"", "Reactome:R-HSA-1482897 \"PS is hydrolyzed to 2-acyl LPS by PLA2[10]\"", "Reactome:R-HSA-1482900 \"PG is hydrolyzed to 1-acyl LPG by PLA2[1]\"", "Reactome:R-HSA-1482907 \"PG is hydrolyzed to 1-acyl LPG by PLA2G2A\"", "Reactome:R-HSA-1602368 \"PG is hydrolyzed to 1-acyl LPG by PLA2[16]\"", "Reactome:R-HSA-1602374 \"PS is hydrolyzed to 1-acyl LPS by PLA2[15]\"", "Reactome:R-HSA-1602377 \"PI is hydrolyzed to 1-acyl LPI by PLA2[15]\"", "Reactome:R-HSA-1602398 \"PE is hydrolyzed to 1-acyl LPE by PLA2[16]\"", "Reactome:R-HSA-1602399 \"PC is hydrolyzed to 1-acyl LPC by PLB1\"", "Reactome:R-HSA-1602417 \"PC is hydrolyzed to 1-acyl LPC by PLA2[16]\"", "Reactome:R-HSA-1602446 \"PA is hydrolyzed to 1-acyl LPA by PLA2[15]\"", "Reactome:R-HSA-8848484 \"PLA2s hydrolyze phospholipids at the Golgi membrane\"", "Reactome:R-HSA-8952251 \"PLA2G15 hydrolyses LPC to GPCho and LCFA(-)\"", "RHEA:15801", "RHEA:38779", "RHEA:38847", "RHEA:40427", "RHEA:40519", "RHEA:40643", "RHEA:40651", "RHEA:40811", "RHEA:41223", "RHEA:53500", "RHEA:56428", "RHEA:62036" ], "previous": [ "EC:3.1.1.4", "MetaCyc:PHOSPHOLIPASE-A2-RXN", "MetaCyc:RXN-15065", "MetaCyc:RXN-15067", "Reactome:R-HSA-1482604 \"PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)\"", "Reactome:R-HSA-1482656 \"PA is hydrolysed to 1-acyl LPA by PLA2[1]\"", "Reactome:R-HSA-1482679 \"PA is hydrolysed to 1-acyl LPA by PLA2G2A\"", "Reactome:R-HSA-1482745 \"PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)\"", "Reactome:R-HSA-1482759 \"MLCL is hydrolyzed to DLCL by PLA2G4A (IM)\"", "Reactome:R-HSA-1482771 \"PS is hydrolyzed to 1-acyl LPS by PLA2[9]\"", "Reactome:R-HSA-1482776 \"PS is hydrolyzed to 1-acyl LPS by PLA2G2A\"", "Reactome:R-HSA-1482778 \"CL is hydrolyzed to MLCL by PLA2G6 (IM)\"", "Reactome:R-HSA-1482816 \"PC is hydrolyzed to 1-acyl LPC by PLA2[6]\"", "Reactome:R-HSA-1482825 \"PI is hydrolyzed to 1-acyl LPI by PLA2[11]\"", "Reactome:R-HSA-1482856 \"PC is hydrolyzed to 1-acyl LPC by PLA2[5]\"", "Reactome:R-HSA-1482868 \"PI is hydrolyzed to 1-acyl LPI by PLA2[12]\"", "Reactome:R-HSA-1482884 \"PE is hydrolyzed to 1-acyl LPE by PLA2[2]\"", "Reactome:R-HSA-1482887 \"PE is hydrolyzed to 1-acyl LPE by PLA2[3]\"", "Reactome:R-HSA-1482897 \"PS is hydrolyzed to 2-acyl LPS by PLA2[10]\"", "Reactome:R-HSA-1482900 \"PG is hydrolyzed to 1-acyl LPG by PLA2[1]\"", "Reactome:R-HSA-1482907 \"PG is hydrolyzed to 1-acyl LPG by PLA2G2A\"", "Reactome:R-HSA-1602368 \"PG is hydrolyzed to 1-acyl LPG by PLA2[16]\"", "Reactome:R-HSA-1602374 \"PS is hydrolyzed to 1-acyl LPS by PLA2[15]\"", "Reactome:R-HSA-1602377 \"PI is hydrolyzed to 1-acyl LPI by PLA2[15]\"", "Reactome:R-HSA-1602398 \"PE is hydrolyzed to 1-acyl LPE by PLA2[16]\"", "Reactome:R-HSA-1602399 \"PC is hydrolyzed to 1-acyl LPC by PLB1\"", "Reactome:R-HSA-1602417 \"PC is hydrolyzed to 1-acyl LPC by PLA2[16]\"", "Reactome:R-HSA-1602446 \"PA is hydrolyzed to 1-acyl LPA by PLA2[15]\"", "Reactome:R-HSA-8848484 \"PLA2s hydrolyze phospholipids at the Golgi membrane\"", "RHEA:15801" ] } } }, { "id": "GO:0004630", "name": "D-type glycerophospholipase activity", "changes": { "xrefs": { "current": [ "EC:3.1.4.4", "MetaCyc:PHOSCHOL-RXN", "Reactome:R-HSA-1483142 \"PC is transphosphatidylated to PG by PLD1-4/6\"", "Reactome:R-HSA-1483182 \"PC is hydrolyzed to PA and choline by PLD1/2\"", "Reactome:R-HSA-2029471 \"Hydrolysis of PC to PA by PLD\"", "RHEA:14445", "RHEA:41412", "RHEA:41416" ], "previous": [ "EC:3.1.4.4", "MetaCyc:PHOSCHOL-RXN", "Reactome:R-HSA-1483142 \"PC is transphosphatidylated to PG by PLD1-4/6\"", "Reactome:R-HSA-1483182 \"PC is hydrolyzed to PA and choline by PLD1/2\"", "Reactome:R-HSA-2029471 \"Hydrolysis of PC to PA by PLD\"", "RHEA:14445" ] } } }, { "id": "GO:0004674", "name": "protein serine/threonine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.11.-", "EC:2.7.11.1", "EC:2.7.11.28", "EC:2.7.11.29", "EC:2.7.11.3", "EC:2.7.11.9", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by AKT (PKB)\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK phosphorylates CDK1 bound to CCNB1\"", "Reactome:R-HSA-170087 \"CAK phosphorylates CDK1 bound to CCNA\"", "Reactome:R-HSA-170116 \"PKMYT1 phosphorylates CCNA:CDK1\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193703 \"IKKbeta is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"mTORC2 phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5623667 \"PDPK1 phosphorylates PKN1,2,3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5625784 \"PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671749 \"p-T774-PKN1 phosphorylates CDC25C\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"mTORC2 phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of CDC25A by CHEK1\"", "Reactome:R-HSA-69608 \"Phosphorylation of CDC25A by CHEK2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9021357 \"PRKCI phosphorylates ELF3\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-927889 \"SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632858 \"PRKCZ autophosphorylates downstream of estrogen stimulation\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9765960 \"ERKs phosphorylate MCRIP1\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796053 \"PRKCI phosphorylates NFE2L2\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9857661 \"p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)\"", "Reactome:R-HSA-9857673 \"p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"", "Reactome:R-HSA-9909369 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-9912396 \"CDK5 phosphorylates CLOCK on serine-451 and serine-461\"", "Reactome:R-HSA-9912401 \"CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90\"", "Reactome:R-HSA-9920673 \"CDK5 phosphorylates PER2 on serine-396\"", "Reactome:R-HSA-9922273 \"CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene\"", "Reactome:R-HSA-9926483 \"MARK3 phosphorylates MITF-M on S173\"", "Reactome:R-HSA-9929360 \"GSK3B phosphorylates CD274\"", "Reactome:R-HSA-9931292 \"AMPK phosphorylates CD274\"", "Reactome:R-HSA-9931409 \"NEK2 phosphorylates CD274\"", "Reactome:R-HSA-9931418 \"CK2 phosphorylates CD274\"", "Reactome:R-HSA-9933380 \"Cytosolic tail of CDH1 is phosphorylated\"", "Reactome:R-HSA-9942578 \"Phosphorylation of CDC25A by p38 MAPK\"", "Reactome:R-HSA-9943662 \"CHEK1 phosphorylates NEK11\"", "Reactome:R-HSA-9943675 \"GSK3B phosphorylates CDC25A\"", "Reactome:R-HSA-9943676 \"NEK11 phosphorylates CDC25A\"", "Reactome:R-HSA-9943678 \"CHEK1 phosphorylates CHEK2-phosphorylated CDC25A\"", "Reactome:R-HSA-9943687 \"PLK3 phosphorylates CDC25A\"", "Reactome:R-HSA-9943736 \"Casein kinase I phosphorylates CDC25A\"", "Reactome:R-HSA-9954237 \"PIM1 phosphorylates GBP1\"", "Reactome:R-HSA-9975250 \"PGK1 phosphorylates AKT1S1\"" ], "previous": [ "EC:2.7.11.-", "EC:2.7.11.1", "EC:2.7.11.28", "EC:2.7.11.29", "EC:2.7.11.3", "EC:2.7.11.9", "MetaCyc:PROTEIN-KINASE-RXN", "Reactome:R-HSA-109702 \"PDPK1 phosphorylates AKT2\"", "Reactome:R-HSA-109822 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1\"", "Reactome:R-HSA-109823 \"MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2\"", "Reactome:R-HSA-109860 \"MAP2K1 phosphorylates MAPK3\"", "Reactome:R-HSA-109862 \"MAP2K2 phosphorylates MAPK1\"", "Reactome:R-HSA-111919 \"PKA phosphorylates CREB1\"", "Reactome:R-HSA-111970 \"PKC phosphorylates GRK2\"", "Reactome:R-HSA-112342 \"Inactivation of MAP2K1 by CDK1\"", "Reactome:R-HSA-112381 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-1168635 \"PRKCB (PKC-beta) phosphorylates CARMA1\"", "Reactome:R-HSA-1168638 \"Activated IKK phosphorylates I-kappaB\"", "Reactome:R-HSA-1168641 \"TAK1 associated with the CBM complex phosphorylates IKKbeta\"", "Reactome:R-HSA-1181149 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin\"", "Reactome:R-HSA-1181156 \"Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL\"", "Reactome:R-HSA-1181355 \"Phosphorylation of R-SMAD2/3 by NODAL receptor\"", "Reactome:R-HSA-1225894 \"Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL\"", "Reactome:R-HSA-1358791 \"Phosphorylation of USP8 by P-AKT\"", "Reactome:R-HSA-1362270 \"Phosphorylation of LIN52 component of MuvB by DYRK1A\"", "Reactome:R-HSA-139908 \"Phosphorylation of DLC2 by MAPK8\"", "Reactome:R-HSA-139918 \"Phosphorylation of BIM by JNK\"", "Reactome:R-HSA-1445144 \"p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)\"", "Reactome:R-HSA-1449597 \"p-AKT2 phosphorylates Myosin 5A\"", "Reactome:R-HSA-1454699 \"AMPK-alpha2 phosphorylates TBC1D1\"", "Reactome:R-HSA-1458463 \"p-AKT2 phosphorylates RGC2\"", "Reactome:R-HSA-1549526 \"Phosphorylation of SMAD2,3 by Activin:Activin Receptor\"", "Reactome:R-HSA-156673 \"Regulation of KIF23 (MKLP1) by phosphorylation\"", "Reactome:R-HSA-156678 \"Activation of Cdc25C\"", "Reactome:R-HSA-156682 \"PLK1 phosphorylates NUDC\"", "Reactome:R-HSA-156699 \"Inactivation of Wee1 kinase\"", "Reactome:R-HSA-156723 \"Regulation of KIF20A (MKL2) by phosphorylation\"", "Reactome:R-HSA-1592233 \"p38 MAPK phosphorylates PPARGC1A\"", "Reactome:R-HSA-162363 \"p-T309,S474-AKT2:PIP3 phosphorylates PDE3B\"", "Reactome:R-HSA-162657 \"Inactivation of Myt1 kinase\"", "Reactome:R-HSA-163010 \"Down Regulation of Emi1 through Phosphorylation of Emi1\"", "Reactome:R-HSA-1632857 \"ULK1 phosphorylates AMBRA1:BECN1 complex\"", "Reactome:R-HSA-163416 \"hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP\"", "Reactome:R-HSA-163418 \"perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP\"", "Reactome:R-HSA-1638803 \"Phosphorylation of cohesin by PLK1 at centromeres\"", "Reactome:R-HSA-164151 \"LKB1 phosphorylates the alpha subunit of AMPK heterotrimer\"", "Reactome:R-HSA-165162 \"Phosphorylation of TSC2 by PKB\"", "Reactome:R-HSA-165182 \"Phosphorylation of complexed TSC2 by PKB\"", "Reactome:R-HSA-165692 \"Phosphorylation of 4E-BP1 by activated mTORC1\"", "Reactome:R-HSA-165718 \"mTORC1 phosphorylation of RPS6KB1 (S6K)\"", "Reactome:R-HSA-165726 \"Phosphorylation of Ribosomal protein S6 by activated S6K1\"", "Reactome:R-HSA-165758 \"Phosphorylation and inactivation of eEF2K by activated S6K1\"", "Reactome:R-HSA-165766 \"Phosphorylation and activation of eIF4G by activated S6K1\"", "Reactome:R-HSA-165777 \"Phosphorylation and activation of eIF4B by activated S6K1\"", "Reactome:R-HSA-166119 \"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal\"", "Reactome:R-HSA-166245 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex\"", "Reactome:R-HSA-166284 \"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-166286 \"Multiple IRAK1 autophosphorylation steps\"", "Reactome:R-HSA-167084 \"Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex\"", "Reactome:R-HSA-167098 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-168053 \"Phosphorylated MAPKs phosphorylate ATF-2\"", "Reactome:R-HSA-168140 \"Active IKK Complex phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-168184 \"Activated TAK1 mediates phosphorylation of the IKK Complex\"", "Reactome:R-HSA-170055 \"Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes\"", "Reactome:R-HSA-170076 \"CAK phosphorylates CDK1 bound to CCNB1\"", "Reactome:R-HSA-170087 \"CAK phosphorylates CDK1 bound to CCNA\"", "Reactome:R-HSA-170116 \"PKMYT1 phosphorylates CCNA:CDK1\"", "Reactome:R-HSA-170126 \"Phosphorylation of Cyclin B1 in the CRS domain\"", "Reactome:R-HSA-170977 \"FRS2 is phosphorylated by active TrkA receptor\"", "Reactome:R-HSA-174119 \"Free APC/C phosphorylated by Plk1\"", "Reactome:R-HSA-174174 \"Phosphorylation of the Emi1 DSGxxS degron by Plk1\"", "Reactome:R-HSA-176116 \"Recruitment and activation of Chk1\"", "Reactome:R-HSA-176298 \"Activation of claspin\"", "Reactome:R-HSA-187688 \"p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3\"", "Reactome:R-HSA-187949 \"CAK-mediated phosphorylation of Cyclin A:Cdk2\"", "Reactome:R-HSA-188350 \"CAK-mediated phosphorylation of Cyclin E:Cdk2\"", "Reactome:R-HSA-193647 \"IRAK is activated\"", "Reactome:R-HSA-193703 \"IKKbeta is activated\"", "Reactome:R-HSA-193705 \"IKKbeta phosphorylates IkB causing NF-kB to dissociate\"", "Reactome:R-HSA-195275 \"Phosphorylation of APC component of the destruction complex\"", "Reactome:R-HSA-195283 \"Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3\"", "Reactome:R-HSA-195287 \"Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3\"", "Reactome:R-HSA-195300 \"Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3\"", "Reactome:R-HSA-195318 \"Phosphorylation of beta-catenin at Ser45 by CK1 alpha\"", "Reactome:R-HSA-198270 \"PDPK1 phosphorylates AKT at T308\"", "Reactome:R-HSA-198347 \"AKT phosphorylates BAD\"", "Reactome:R-HSA-198371 \"AKT phosphorylates GSK3\"", "Reactome:R-HSA-198599 \"AKT phosphorylates MDM2\"", "Reactome:R-HSA-198609 \"AKT phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-198611 \"AKT phosphorylates IKKalpha\"", "Reactome:R-HSA-198613 \"AKT phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-198621 \"AKT phosphorylates caspase-9\"", "Reactome:R-HSA-198640 \"TORC2 (mTOR) phosphorylates AKT at S473\"", "Reactome:R-HSA-198669 \"p38MAPK phosphorylates MSK1\"", "Reactome:R-HSA-198731 \"ERK1/2 activates ELK1\"", "Reactome:R-HSA-198746 \"ERK1/2/5 activate RSK1/2/3\"", "Reactome:R-HSA-198756 \"ERK1/2 phosphorylates MSK1\"", "Reactome:R-HSA-199298 \"AKT phosphorylates CREB1\"", "Reactome:R-HSA-199299 \"AKT phosphorylates FOXO transcription factors\"", "Reactome:R-HSA-199839 \"AKT can phosphorylate RSK\"", "Reactome:R-HSA-199863 \"AKT can phosphorylate NR4A1 (NUR77)\"", "Reactome:R-HSA-199895 \"RSK1/2/3 phosphorylates CREB at Serine 119\"", "Reactome:R-HSA-199910 \"MSK1 activates ATF1\"", "Reactome:R-HSA-199917 \"MAPKAPK2 phosphorylates CREB at Serine 133\"", "Reactome:R-HSA-199929 \"ERK5 activates the transcription factor MEF2\"", "Reactome:R-HSA-199935 \"MSK1 activates CREB\"", "Reactome:R-HSA-200143 \"AKT phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-200421 \"Activation of cytosolic AMPK by phosphorylation\"", "Reactome:R-HSA-201677 \"Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta\"", "Reactome:R-HSA-201691 \"Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI\"", "Reactome:R-HSA-201717 \"CSNK2-mediated phosphorylation of DVL\"", "Reactome:R-HSA-202111 \"AKT1 phosphorylates eNOS\"", "Reactome:R-HSA-202222 \"Phosphorylation of PKC theta\"", "Reactome:R-HSA-202437 \"Phosphorylation of CARMA1\"", "Reactome:R-HSA-202459 \"Phosphorylation of Bcl10\"", "Reactome:R-HSA-202500 \"Activation of IKK complex\"", "Reactome:R-HSA-202510 \"Activation of TAK1-TAB2 complex\"", "Reactome:R-HSA-202541 \"p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB\"", "Reactome:R-HSA-2028284 \"Phosphorylation of STK4 (MST1) and SAV1 by STK4\"", "Reactome:R-HSA-2028555 \"Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028583 \"Phosphorylation of YAP by LATS2\"", "Reactome:R-HSA-2028589 \"Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028591 \"Phosphorylation of STK3 (MST2) and SAV1 by STK3\"", "Reactome:R-HSA-2028598 \"Phosphorylation of YAP by LATS1\"", "Reactome:R-HSA-2028629 \"Phosphorylation of MOB1A and B by p-STK4 (p-MST1)\"", "Reactome:R-HSA-2028635 \"Phosphorylation of MOB1A and B by p-STK3 (p-MST2)\"", "Reactome:R-HSA-2028661 \"Phosphorylation of WWTR1 (TAZ) by LATS2\"", "Reactome:R-HSA-2028670 \"Phosphorylation of MOB1A and B by p-STK4(MST1)/N\"", "Reactome:R-HSA-2028673 \"Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N\"", "Reactome:R-HSA-2028675 \"Phosphorylation of MOB1A and B by p-STK3(MST2)/N\"", "Reactome:R-HSA-2028679 \"Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N\"", "Reactome:R-HSA-2029454 \"Autophosphorylation of PAK1\"", "Reactome:R-HSA-2029460 \"PAK1 phosphorylates LIMK1\"", "Reactome:R-HSA-2029469 \"p-ERK phosphorylates WAVEs and ABI\"", "Reactome:R-HSA-2060328 \"Phosphorylation of WWTR1 (TAZ) by LATS1\"", "Reactome:R-HSA-209087 \"IKBA is phosphorylated by Phospho IKKB kinase\"", "Reactome:R-HSA-211164 \"AKT phosphorylates FOXO1A\"", "Reactome:R-HSA-211583 \"Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197\"", "Reactome:R-HSA-211650 \"Autophosphorylation of PAK-2p34 in the activation loop\"", "Reactome:R-HSA-2168079 \"MASTL (GWL) phosphorylates ARPP19\"", "Reactome:R-HSA-2176475 \"Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9\"", "Reactome:R-HSA-2214351 \"PLK1 phosphorylates GORASP1\"", "Reactome:R-HSA-2243938 \"AKT1 E17K mutant is phosphorylated by TORC2 complex\"", "Reactome:R-HSA-2243942 \"PDPK1 phosphorylates AKT1 E17K mutant\"", "Reactome:R-HSA-2294580 \"PLK1 hyperphosphorylates Condensin II complex\"", "Reactome:R-HSA-2396007 \"IRF3 is phosphorylated by TBK1\"", "Reactome:R-HSA-2399941 \"AKT1 E17K mutant phosphorylates BAD\"", "Reactome:R-HSA-2399966 \"AKT1 E17K mutant phosphorylates GSK3\"", "Reactome:R-HSA-2399969 \"AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1\"", "Reactome:R-HSA-2399977 \"AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-2399981 \"AKT1 E17K mutant phosphorylates MDM2\"", "Reactome:R-HSA-2399982 \"AKT1 E17K mutant phosphorylates TSC2, inhibiting it\"", "Reactome:R-HSA-2399985 \"AKT1 E17K mutant phosphorylates caspase-9\"", "Reactome:R-HSA-2399988 \"AKT1 E17K mutant phosphorylates NR4A1 (NUR77)\"", "Reactome:R-HSA-2399992 \"AKT1 E17K mutant phosphorylates forkhead box transcription factors\"", "Reactome:R-HSA-2399996 \"AKT1 E17K mutant phosphorylates CREB1\"", "Reactome:R-HSA-2399999 \"AKT1 E17K mutant phosphorylates RSK\"", "Reactome:R-HSA-2400001 \"AKT1 E17K mutant phosphorylates CHUK (IKKalpha)\"", "Reactome:R-HSA-2422927 \"MAPK3-3 or MAPK1 phosphorylate GORASP2\"", "Reactome:R-HSA-2430535 \"MASTL phosphorylates ENSA\"", "Reactome:R-HSA-2466068 \"Phosphorylation of cohesin by PLK1 at chromosomal arms\"", "Reactome:R-HSA-2470508 \"ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin\"", "Reactome:R-HSA-2529020 \"CK2 phosphorylates condensin I subunits\"", "Reactome:R-HSA-2562526 \"PLK1 phosphorylates OPTN\"", "Reactome:R-HSA-2574840 \"AJUBA facilitates AURKA autophosphorylation\"", "Reactome:R-HSA-2730856 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-2730868 \"Phosphorylation of MEK7 by MEKK1\"", "Reactome:R-HSA-2730876 \"Phosphorylation of IKK-beta by TAK1\"", "Reactome:R-HSA-2730896 \"Phosphorylation of MEK4 by MEKK1\"", "Reactome:R-HSA-2730900 \"Activation of TAK1 complex bound to pUb-TRAF6\"", "Reactome:R-HSA-2984226 \"PLK1 phosphorylates NEK9\"", "Reactome:R-HSA-2984258 \"NEK9 phosphorylates NEK6/NEK7\"", "Reactome:R-HSA-2990880 \"NEK6/NEK7 phosphorylates NUP98\"", "Reactome:R-HSA-2993898 \"VRK1/VRK2 phosphorylate BANF1\"", "Reactome:R-HSA-3000310 \"AURKA phosphorylates PLK1\"", "Reactome:R-HSA-3000327 \"PLK1 phosphorylates BORA\"", "Reactome:R-HSA-3132737 \"MAPKs phosphorylate ETS1 and ETS2\"", "Reactome:R-HSA-3209160 \"Activated ERKs phosphorylate ERF\"", "Reactome:R-HSA-3222006 \"STK11 (LKB1) phosphorylates NUAK1\"", "Reactome:R-HSA-3222020 \"NUAK1 phosphorylates TP53\"", "Reactome:R-HSA-3228469 \"MAP3K5 phosphorylates MKK3 and MKK6\"", "Reactome:R-HSA-3229102 \"p-MAPKAPK3 phosphorylates BMI1\"", "Reactome:R-HSA-3229152 \"MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)\"", "Reactome:R-HSA-3239014 \"MAPKAPK5 phosphorylates TP53\"", "Reactome:R-HSA-3239019 \"Active p38 MAPK phosphorylates MAPKAPK5\"", "Reactome:R-HSA-3249371 \"TBK1 phosphorylates STAT6 at Ser407\"", "Reactome:R-HSA-3371435 \"Constitutive phosphorylation by GSK3\"", "Reactome:R-HSA-3371531 \"Constitutive phosphorylation by pERK1/2\"", "Reactome:R-HSA-3371567 \"DBC1 is phosphorylated by ATM/ART\"", "Reactome:R-HSA-349426 \"Phosphorylation of MDM4 by CHEK2\"", "Reactome:R-HSA-349444 \"Phosphorylation of COP1 at Ser-387 by ATM\"", "Reactome:R-HSA-349455 \"Phosphorylation of MDM4 by ATM\"", "Reactome:R-HSA-374696 \"Phosphorylation of L1 by p90rsk\"", "Reactome:R-HSA-3769394 \"AKT phosphorylates CBY1\"", "Reactome:R-HSA-377186 \"Activated Akt1 phosphorylates AKT1S1 (PRAS40)\"", "Reactome:R-HSA-3772435 \"WNT signaling stimulates CSNK1-dependent phosphorylation of DVL\"", "Reactome:R-HSA-380272 \"Plk1-mediated phosphorylation of Nlp\"", "Reactome:R-HSA-381091 \"IRE1 dimer autophosphorylates\"", "Reactome:R-HSA-381111 \"EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK\"", "Reactome:R-HSA-3857328 \"RPS6KA1/2/3 phosphorylates CEBPB on S321\"", "Reactome:R-HSA-3857329 \"MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB\"", "Reactome:R-HSA-3858480 \"WNT-dependent phosphorylation of DVL\"", "Reactome:R-HSA-389756 \"AKT interacts and phosphorylates Cot\"", "Reactome:R-HSA-392752 \"Phosphorylation of L1 by CK-II\"", "Reactome:R-HSA-3928577 \"ROCK phosphorylates LIMK1,2\"", "Reactome:R-HSA-3928608 \"LIMK phosphorylates CFL1, inactivating it\"", "Reactome:R-HSA-3928616 \"Activated ROCK phosphorylates MRLCs\"", "Reactome:R-HSA-3928620 \"PAK1 autophosphorylates\"", "Reactome:R-HSA-3928625 \"PAKs autophosphorylate\"", "Reactome:R-HSA-3928640 \"PAKs phosphorylate MLC\"", "Reactome:R-HSA-399939 \"Autophosphorylation of PAK\"", "Reactome:R-HSA-399944 \"Phosphorylation of CRMPs by Cdk5\"", "Reactome:R-HSA-399950 \"Phosphorylation of cofilin by LIMK-1\"", "Reactome:R-HSA-399951 \"Phosphorylation of CRMPs by GSK3beta\"", "Reactome:R-HSA-399952 \"Phosphorylation of LIMK-1 by PAK\"", "Reactome:R-HSA-399978 \"Protein kinase C, alpha type phosphorylates MARCKS\"", "Reactome:R-HSA-4088134 \"PLK1 phosphorylates FOXM1\"", "Reactome:R-HSA-419083 \"Myosin phosphatase inactivation by ROCK\"", "Reactome:R-HSA-419087 \"LIM kinase phosphorylation by ROCK\"", "Reactome:R-HSA-419197 \"Myosin regulatory light chain phosphorylation by ROCK\"", "Reactome:R-HSA-419644 \"Transphosphorylation of pLIMK1\"", "Reactome:R-HSA-428961 \"Phosphorylation of cPLA2 by MAPK p38 alpha\"", "Reactome:R-HSA-429016 \"ALOX5 is phosphorylated by MAPKAP2\"", "Reactome:R-HSA-429714 \"CSNK1G2 phosphorylates p-CERT1-2\"", "Reactome:R-HSA-432110 \"Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding\"", "Reactome:R-HSA-4332358 \"Dissociation of CaM and CAMK2 autophosphorylation\"", "Reactome:R-HSA-4332363 \"Autophosphorylation and activation of CAMK2\"", "Reactome:R-HSA-4332388 \"Activation of MAP3K7 in response to WNT\"", "Reactome:R-HSA-4411383 \"NLK phosphorylates TCF/LEF\"", "Reactome:R-HSA-4411402 \"Activation of NLK\"", "Reactome:R-HSA-442724 \"Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)\"", "Reactome:R-HSA-442739 \"PDPK1 phosphorylates RSKs\"", "Reactome:R-HSA-442832 \"PAK phosphorylates cortactin\"", "Reactome:R-HSA-445072 \"Interaction of PAK1 with Rac1-GTP\"", "Reactome:R-HSA-446694 \"IRAK4 phosphorylates IRAK1\"", "Reactome:R-HSA-446701 \"IRAK4-activated IRAK1 autophosphorylates\"", "Reactome:R-HSA-448948 \"Phosphorylation of E proteins by p38 MAPK\"", "Reactome:R-HSA-448955 \"Phosphorylation of MEF2 proteins by p38\"", "Reactome:R-HSA-450222 \"Active p38 MAPK phosphorylates MAPKAPK2 or 3\"", "Reactome:R-HSA-450325 \"c-FOS activation by phospho ERK1/2\"", "Reactome:R-HSA-450337 \"Activated TAK1 phosphorylates MKK4/MKK7\"", "Reactome:R-HSA-450346 \"activated human TAK1 phosphorylates MKK3/MKK6\"", "Reactome:R-HSA-450463 \"MK2 phosphorylates ZFP36 (Tristetraproline, TTP)\"", "Reactome:R-HSA-450474 \"MK2 phosphorylates BRF1\"", "Reactome:R-HSA-450490 \"Protein Kinase B/Akt phosphorylates BRF1\"", "Reactome:R-HSA-450499 \"Protein Kinase B (AKT) phosphorylates KSRP\"", "Reactome:R-HSA-450827 \"hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2\"", "Reactome:R-HSA-451152 \"MAP kinase p38 phosphorylates KSRP\"", "Reactome:R-HSA-4551570 \"VANGL2 is phosphorylated in response to WNT5A\"", "Reactome:R-HSA-4608825 \"DVL2 is phosphorylated after WNT5A binding to FZD\"", "Reactome:R-HSA-4793911 \"MAPKAPK2 phosphorylates HSF1\"", "Reactome:R-HSA-5082387 \"Phosphorylation of HSF1 at Ser230 induces transactivation\"", "Reactome:R-HSA-5082405 \"Phosphorylation of HSF1 at Ser326 induces transactivation\"", "Reactome:R-HSA-5213464 \"RIPK1 is phosphorylated\"", "Reactome:R-HSA-5213466 \"RIPK3 is phosphorylated\"", "Reactome:R-HSA-5218814 \"PAK2 autophorylates\"", "Reactome:R-HSA-5218821 \"PDK1 phosphorylates PKC\"", "Reactome:R-HSA-5218826 \"Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732\"", "Reactome:R-HSA-5218854 \"p-Y420-FYN is phosphorylated on S21\"", "Reactome:R-HSA-5218906 \"RIPK3 phosphorylates MLKL\"", "Reactome:R-HSA-5218916 \"p-MAPK2/3 phosphorylates HSP27\"", "Reactome:R-HSA-5228811 \"NFKBIA variant is not phosphorylated within IkBA:NF-kappaB\"", "Reactome:R-HSA-5229343 \"AXIN is phosphorylated in the destruction complex\"", "Reactome:R-HSA-5260201 \"p-AKT2 phosphorylates C2CD5\"", "Reactome:R-HSA-5357472 \"PAK1-3 autophosphorylates\"", "Reactome:R-HSA-5357477 \"PAK1-3 phosphorylates VE-cadherin\"", "Reactome:R-HSA-5357831 \"CHUK, IKBKB phosphorylate CYLD at S418\"", "Reactome:R-HSA-5578777 \"DMPK phosphorylates PLN\"", "Reactome:R-HSA-5607722 \"Active NIK phosphorylates IKKA dimer\"", "Reactome:R-HSA-5607726 \"Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB\"", "Reactome:R-HSA-5607732 \"K63polyUb-TAK1 autophosphorylates\"", "Reactome:R-HSA-5607742 \"K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta\"", "Reactome:R-HSA-5610718 \"CK1 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610722 \"CK1 phosphorylates p-GLI3\"", "Reactome:R-HSA-5610730 \"GSK3 phosphorylates p-GLI2\"", "Reactome:R-HSA-5610732 \"GSK3 phosphorylates p-GLI3\"", "Reactome:R-HSA-5623667 \"PDPK1 phosphorylates PKN1,2,3\"", "Reactome:R-HSA-5624473 \"Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit\"", "Reactome:R-HSA-5624492 \"PAK phosphorylates p21 RAF1 on S338\"", "Reactome:R-HSA-5625784 \"PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters\"", "Reactome:R-HSA-5627775 \"Autophosphorylation of PAK1,2,3\"", "Reactome:R-HSA-5632670 \"CSNK1A1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5632672 \"ADRBK1 phosphorylates SMO dimer\"", "Reactome:R-HSA-5635841 \"GLI proteins are phosphorylated\"", "Reactome:R-HSA-5635842 \"ULK3 phosphorylates GLI\"", "Reactome:R-HSA-5665868 \"AMPK (complex) phosphorylates ULK1 (complex)\"", "Reactome:R-HSA-5666160 \"AURKB phosphorylates DIAPH2-2 at kinetochores\"", "Reactome:R-HSA-5668545 \"NIK autophosphorylates on T559\"", "Reactome:R-HSA-5668932 \"PAK2 phosphorylates myosin regulatory light chain (MRLC)\"", "Reactome:R-HSA-5668947 \"PAK1 phosphorylates myosin phosphatase\"", "Reactome:R-HSA-5668984 \"PAK1 or PAK2 phosphorylates MYLK\"", "Reactome:R-HSA-5669250 \"PAK1 phosphorylates FLNA\"", "Reactome:R-HSA-5671749 \"p-T774-PKN1 phosphorylates CDC25C\"", "Reactome:R-HSA-5671763 \"p-T774-PKN1 phosphorylates PPP1R14A\"", "Reactome:R-HSA-5671919 \"Activated CIT phosphorylates MRLCs\"", "Reactome:R-HSA-5672008 \"Thr-180 of ULK1 is phosphorylated\"", "Reactome:R-HSA-5672010 \"Active MTORC1 phosphorylates ULK1\"", "Reactome:R-HSA-5672828 \"mTORC1 phosphorylates AKT1S1\"", "Reactome:R-HSA-5672948 \"MARK3 phosphorylates KSR1\"", "Reactome:R-HSA-5672973 \"MAP2Ks phosphorylate MAPKs\"", "Reactome:R-HSA-5672978 \"RAF phosphorylates MAP2K dimer\"", "Reactome:R-HSA-5674496 \"Activated MAPKs phosphorylate MAP2K1\"", "Reactome:R-HSA-5675194 \"Activated MAPK phosphorylates RAF1\"", "Reactome:R-HSA-5675198 \"Activated MAPKs phosphorylate BRAF\"", "Reactome:R-HSA-5675868 \"ULK1 phosphorylates ATG13 and RB1CC1\"", "Reactome:R-HSA-5679205 \"ULK1 phosphorylates Beclin-1\"", "Reactome:R-HSA-5682026 \"MRN bound to shortened telomeres activates ATM\"", "Reactome:R-HSA-5682101 \"PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer\"", "Reactome:R-HSA-5682598 \"ATM phosphorylates HERC2\"", "Reactome:R-HSA-5682983 \"ATM phosphorylates WHSC1\"", "Reactome:R-HSA-5683425 \"ATM phosphorylates TP53BP1 at DNA DSBs\"", "Reactome:R-HSA-5683792 \"p-T68-CHEK2 autophosphorylates\"", "Reactome:R-HSA-5683801 \"CHEK2 phosphorylates BRCA1\"", "Reactome:R-HSA-5683964 \"ATM phosphorylates EYA1-4\"", "Reactome:R-HSA-5684096 \"CDK2 phosphorylates RBBP8\"", "Reactome:R-HSA-5684140 \"ATM phosphorylates RBBP8\"", "Reactome:R-HSA-5684887 \"Activation of CHEK1 at resected DNA DSBs\"", "Reactome:R-HSA-5685156 \"ATR phosphorylates RPA2\"", "Reactome:R-HSA-5685230 \"CHEK1 phosphorylates RAD51\"", "Reactome:R-HSA-5685242 \"CHEK1 phosphorylates BRCA2\"", "Reactome:R-HSA-5686578 \"Activated ATM phosphorylates ABL1\"", "Reactome:R-HSA-5686704 \"Activated ATM phosphorylates DCLRE1C\"", "Reactome:R-HSA-5687086 \"PAK1,2,3 phosphorylates MAPK6,4\"", "Reactome:R-HSA-5687090 \"p-S MAPK6 phosphorylates NCOA3\"", "Reactome:R-HSA-5687094 \"p-S MAPK6,4 phosphorylate MAPKAPK5\"", "Reactome:R-HSA-5687101 \"p-T182 MAPKAPK5 phosphorylates FOXO3\"", "Reactome:R-HSA-5687121 \"p-S MAPKAPK5 phosphorylates HSPB1\"", "Reactome:R-HSA-5687183 \"PRKDC phosphorylates DCLRE1C at DNA DSBs\"", "Reactome:R-HSA-5690250 \"p-T182-MAPKAPK5 phoshphorylates DNAJB1\"", "Reactome:R-HSA-5692768 \"MAPKAPK5 phosphorylates KALRN\"", "Reactome:R-HSA-5692775 \"SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs\"", "Reactome:R-HSA-5692779 \"p-T182 MAPKAPK5 phosphorylates FOXO1\"", "Reactome:R-HSA-5693536 \"ATM phosphorylates MDC1\"", "Reactome:R-HSA-5693540 \"MRN activates ATM\"", "Reactome:R-HSA-5693549 \"ATM phosphorylates histone H2AFX on S139 at DNA DSBs\"", "Reactome:R-HSA-5693551 \"Phosphorylation of BRCA1-A complex at multiple sites by ATM\"", "Reactome:R-HSA-5693575 \"DNA-PKcs autophosphorylates\"", "Reactome:R-HSA-5693598 \"ATM phosphorylates NBN\"", "Reactome:R-HSA-5693609 \"ATM phosphorylates TP53 at S15\"", "Reactome:R-HSA-5694441 \"CSNK1D phosphorylates SEC23\"", "Reactome:R-HSA-6788392 \"ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA\"", "Reactome:R-HSA-6795290 \"TORC2 complex phosphorylates SGK1\"", "Reactome:R-HSA-6795460 \"SGK1 phosphorylates MDM2\"", "Reactome:R-HSA-6795473 \"PDPK1 phosphorylates SGK1\"", "Reactome:R-HSA-6798372 \"ATM phosphorylates DYRK2\"", "Reactome:R-HSA-6798374 \"DYRK2 phosphorylates TP53\"", "Reactome:R-HSA-6799097 \"ATM phosphorylates ZNF420\"", "Reactome:R-HSA-6799246 \"CHEK1 phosphorylates TP53\"", "Reactome:R-HSA-6799332 \"ATR phosphorylates TP53\"", "Reactome:R-HSA-6799409 \"HIPK2 phosphorylates TP53\"", "Reactome:R-HSA-6800490 \"ATM phosphorylates PIDD1\"", "Reactome:R-HSA-6801666 \"PLK2 phosphorylates CENPJ\"", "Reactome:R-HSA-6801675 \"PLK2 phosphorylates NPM1\"", "Reactome:R-HSA-6802911 \"High kinase activity BRAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802919 \"RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802926 \"Mutant RAS:p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802933 \"p-BRAF and RAF fusion dimers phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802935 \"MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers\"", "Reactome:R-HSA-6802943 \"RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks\"", "Reactome:R-HSA-6802973 \"PLK3 phosphorylates CDC25C\"", "Reactome:R-HSA-6804266 \"CHEK2 phosphorylates TTC5\"", "Reactome:R-HSA-6804276 \"ATM phosphorylates TTC5\"", "Reactome:R-HSA-6804955 \"ATM phosphorylates MDM2\"", "Reactome:R-HSA-6805059 \"CK2:FACT phosphorylates TP53\"", "Reactome:R-HSA-6805103 \"AURKA phosphorylates TP53\"", "Reactome:R-HSA-6805126 \"AURKB phosphorylates TP53\"", "Reactome:R-HSA-6805276 \"CDK5 phosphorylates TP53\"", "Reactome:R-HSA-6805285 \"PLK3 phosphorylates TP53\"", "Reactome:R-HSA-6805399 \"TAF1 phosphorylates TP53\"", "Reactome:R-HSA-6805479 \"TP53RK phosphorylates TP53\"", "Reactome:R-HSA-6805640 \"AKT phosphorylates KAT6A\"", "Reactome:R-HSA-6805785 \"AKT phosphorylates PHF20\"", "Reactome:R-HSA-6810233 \"CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter\"", "Reactome:R-HSA-6811454 \"MAPKs phosphorylate PP2A\"", "Reactome:R-HSA-6814409 \"CK2 phosphorylates PDCL\"", "Reactome:R-HSA-69604 \"Phosphorylation of CDC25A by CHEK1\"", "Reactome:R-HSA-69608 \"Phosphorylation of CDC25A by CHEK2\"", "Reactome:R-HSA-69685 \"CHEK2 phosphorylates TP53\"", "Reactome:R-HSA-69891 \"Phosphorylation and activation of CHEK2 by ATM\"", "Reactome:R-HSA-75010 \"Phosphorylation of Cdc25C at Ser 216 by Chk1\"", "Reactome:R-HSA-75028 \"Phosphorylation of Wee1 kinase by Chk1\"", "Reactome:R-HSA-75809 \"Phosphorylation of Cdc25C at Ser216 by CHEK2\"", "Reactome:R-HSA-75820 \"Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta\"", "Reactome:R-HSA-77071 \"Phosphorylation (Ser5) of RNA pol II CTD\"", "Reactome:R-HSA-8850945 \"Casein kinase II phosphorylates PTEN\"", "Reactome:R-HSA-8852306 \"Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends\"", "Reactome:R-HSA-8852317 \"PLK1 phosphorylates GTSE1\"", "Reactome:R-HSA-8853419 \"TPX2 promotes AURKA autophosphorylation\"", "Reactome:R-HSA-8853444 \"AURKA phosphorylates PHLDA1\"", "Reactome:R-HSA-8854908 \"PKA phosphorylates RET:GDNF:GFRA dimer\"", "Reactome:R-HSA-8856813 \"AAK1 phosphorylates AP-2 mu subunit at T156\"", "Reactome:R-HSA-8863007 \"p25-bound CDK5 phosphorylates CDC25B\"", "Reactome:R-HSA-8863011 \"p25-bound CDK5 phosphorylates CDC25C\"", "Reactome:R-HSA-8863014 \"p25-bound CDK5 phosphorylates CDC25A\"", "Reactome:R-HSA-8863895 \"IKKB phosphorylates SNAP23\"", "Reactome:R-HSA-8868118 \"MAPK12 phosphorylates PTPN3\"", "Reactome:R-HSA-8868260 \"CDK5:p25 phosphorylates GOLGA2\"", "Reactome:R-HSA-8868340 \"CDK5:p25 phosphorylates lamin B1\"", "Reactome:R-HSA-8868344 \"CDK5:p25 phosphorylates lamin A\"", "Reactome:R-HSA-8868567 \"CDK5:p25 phosphorylates PRDX1\"", "Reactome:R-HSA-8868573 \"CDK5:p25 phosphorylates PRDX2\"", "Reactome:R-HSA-8868666 \"CDK5:p25 phosphorylates JUN\"", "Reactome:R-HSA-8870558 \"CDK5:p25 phosphorylates FOXO3\"", "Reactome:R-HSA-8873929 \"Casein kinase II phosphorylates STARD10\"", "Reactome:R-HSA-8876446 \"p-ULK1 phosphorylates DENND3\"", "Reactome:R-HSA-8877691 \"MAP2K6 phosphorylates PIP4K2B\"", "Reactome:R-HSA-8878050 \"HIPK2 phosphorylates RUNX1 and EP300\"", "Reactome:R-HSA-8878054 \"HIPK2 phosphorylates RUNX1\"", "Reactome:R-HSA-8932322 \"CK2 phosphorylates NFE2L2\"", "Reactome:R-HSA-8933446 \"Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling\"", "Reactome:R-HSA-8939963 \"Activated AKT phosphorylates RUNX2\"", "Reactome:R-HSA-8940100 \"CDK1 phosphorylates VCPIP1\"", "Reactome:R-HSA-8942836 \"CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6\"", "Reactome:R-HSA-8944454 \"mTORC1 phosphorylates MAF1\"", "Reactome:R-HSA-8948039 \"FUNDC1 is phosphorylated by CK2\"", "Reactome:R-HSA-8948146 \"FUNDC1 is phosphorylated by ULK1 at Ser17\"", "Reactome:R-HSA-8948757 \"AKT phosphorylates MKRN1\"", "Reactome:R-HSA-8952289 \"FAM20C phosphorylates FAM20C substrates\"", "Reactome:R-HSA-9007539 \"CHEK1 phosphorylates E2F6\"", "Reactome:R-HSA-9008480 \"GSK3B phosphorylates RUNX2\"", "Reactome:R-HSA-9008822 \"PPM1D dephosphorylates RUNX2\"", "Reactome:R-HSA-9009208 \"Activated ERKs phosphorylate RUNX2\"", "Reactome:R-HSA-9012319 \"p-TEFb phosphorylates serine 2 in RNA polymerase II CTD\"", "Reactome:R-HSA-9013978 \"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex\"", "Reactome:R-HSA-9021357 \"PRKCI phosphorylates ELF3\"", "Reactome:R-HSA-9022314 \"HIPK2 phosphorylates MECP2\"", "Reactome:R-HSA-9023132 \"AURKB phosphorylates MECP2 at S423\"", "Reactome:R-HSA-9032751 \"Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3\"", "Reactome:R-HSA-9032863 \"CDK5 phosphorylates NTRK2\"", "Reactome:R-HSA-912470 \"ATR phosphorylates Histone H2A.X at unsynapsed regions\"", "Reactome:R-HSA-913996 \"PKA/PKG phosphorylate Rap1GAP2\"", "Reactome:R-HSA-918229 \"Phosphorylation and release of IRF3/IRF7\"", "Reactome:R-HSA-927889 \"SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)\"", "Reactome:R-HSA-933525 \"Phosphorylation and release of IRF7\"", "Reactome:R-HSA-934559 \"SPRY2 is phosphorylated by phosphorylated MNK1\"", "Reactome:R-HSA-936951 \"Activation of TAK1 complex bound to activated TLR4 complex\"", "Reactome:R-HSA-937022 \"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP\"", "Reactome:R-HSA-937059 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex\"", "Reactome:R-HSA-9604328 \"AKT1 phosphorylates NOTCH4\"", "Reactome:R-HSA-9610153 \"Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF\"", "Reactome:R-HSA-9610156 \"MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF\"", "Reactome:R-HSA-9610163 \"BRAF autophosphorylates downstream of RAP1 and NGF\"", "Reactome:R-HSA-9612501 \"SGK phosphorylates CREB1\"", "Reactome:R-HSA-9612509 \"SGK phosphorylates SRF\"", "Reactome:R-HSA-9612980 \"BRAF in Rap1-GTP complex:BRAF complex autophosphorylates\"", "Reactome:R-HSA-9613530 \"PRKAA2 phosphorylates PLINs\"", "Reactome:R-HSA-9619515 \"AMPK phosphorylates MAPT\"", "Reactome:R-HSA-9619843 \"ERKs phosphorylate RSKs\"", "Reactome:R-HSA-9620004 \"RSKs autophosphorylate\"", "Reactome:R-HSA-9624526 \"AKT phosphorylates FOXO3 downstream of ESR1 and EGFR\"", "Reactome:R-HSA-9626880 \"MAPK11 or MAPK14 phosphorylates NCF1 at Ser345\"", "Reactome:R-HSA-9627089 \"CASP9 is phosphorylated at T412\"", "Reactome:R-HSA-9632858 \"PRKCZ autophosphorylates downstream of estrogen stimulation\"", "Reactome:R-HSA-9632868 \"CDKN1B is phosphorylated in response to estrogen\"", "Reactome:R-HSA-9633008 \"p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1\"", "Reactome:R-HSA-9633742 \"EIF2AK4 (GCN2) dimer autophosphorylates\"", "Reactome:R-HSA-9634702 \"LINC01139 promotes phosphorylation of HIF1A by LRRK2\"", "Reactome:R-HSA-9645535 \"ALPK1 phosphorylates TIFA\"", "Reactome:R-HSA-9648089 \"NEK6 and NEK7 phosphorylate EML4\"", "Reactome:R-HSA-9648883 \"p-T-EIF2AK1:ferriheme dimer autophosphorylates\"", "Reactome:R-HSA-9648888 \"p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)\"", "Reactome:R-HSA-9652165 \"MAP2K mutants constitutively phosphorylate MAPKs\"", "Reactome:R-HSA-9653503 \"KRAS4B is phosphorylated on serine 181\"", "Reactome:R-HSA-9656214 \"MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants\"", "Reactome:R-HSA-9656215 \"RAF1 mutant complexes phosphorylate MAP2K dimer\"", "Reactome:R-HSA-9662823 \"PLK2, MAPK14 phosphorylate ADAM17\"", "Reactome:R-HSA-9673346 \"Unknown kinase phosphorylates p-DVL\"", "Reactome:R-HSA-9683664 \"GSK3 phosphorylates Nucleoprotein\"", "Reactome:R-HSA-9699579 \"AKT phosphorylates FOXO3 downstream of FLT3\"", "Reactome:R-HSA-9705320 \"TBK1, IKBKE are autophosphorylated at Ser172\"", "Reactome:R-HSA-9705323 \"Phosphorylation of TBK1/IKBKE\"", "Reactome:R-HSA-9725030 \"MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner\"", "Reactome:R-HSA-9729260 \"GSK3 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729300 \"Unknown kinase phosphorylates nucleoprotein\"", "Reactome:R-HSA-9729318 \"CSNK1A1 phosphorylates nucleoprotein\"", "Reactome:R-HSA-9731111 \"MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3\"", "Reactome:R-HSA-9734547 \"JAK2-activated MAPKs phosphorylate YBX1\"", "Reactome:R-HSA-975125 \"Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9\"", "Reactome:R-HSA-975134 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88", "Reactome:R-HSA-975160 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975170 \"IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-975180 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9\"", "Reactome:R-HSA-9758486 \"Unknown kinase phosphorylates 9b\"", "Reactome:R-HSA-975853 \"Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR\"", "Reactome:R-HSA-975861 \"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex\"", "Reactome:R-HSA-975865 \"IRAK4 autophosphorylation within the complex activated TLR:MyD88\"", "Reactome:R-HSA-975874 \"Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex\"", "Reactome:R-HSA-975878 \"First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR\"", "Reactome:R-HSA-9762094 \"GSK3B phosphorylates p-NFE2L2\"", "Reactome:R-HSA-9765960 \"ERKs phosphorylate MCRIP1\"", "Reactome:R-HSA-9766532 \"SQSTM1 oligomer is phosphorylated\"", "Reactome:R-HSA-9769115 \"MAPK1,(MAPK3) phosphorylates NPAS4\"", "Reactome:R-HSA-9773803 \"Active IKBKB phosphorylates NF-kappa-B inhibitor\"", "Reactome:R-HSA-9796053 \"PRKCI phosphorylates NFE2L2\"", "Reactome:R-HSA-9796067 \"PRKAA2 phosphorylates nuclear NFE2L2\"", "Reactome:R-HSA-9796081 \"EIF2AK3 phosphorylates NFE2L2\"", "Reactome:R-HSA-9815501 \"MAPKAPK2 phosphorylates RIPK1 at S320\"", "Reactome:R-HSA-9817397 \"TBK1, IKBKE phosphorylate RIPK1 at T189\"", "Reactome:R-HSA-9818789 \"CHUK, IKBKB phosphorylate RIPK1 at S25\"", "Reactome:R-HSA-9819106 \"ULK1 phosphorylates RIPK1 at S357\"", "Reactome:R-HSA-9824582 \"MAPK1 phosphorylates SOX10\"", "Reactome:R-HSA-9824897 \"p-S-TBK1 phosphorylates OPTN\"", "Reactome:R-HSA-9824977 \"MAPK1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824994 \"RPS6KA1-dependent phosphorylation of MITF-M\"", "Reactome:R-HSA-9824995 \"GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405\"", "Reactome:R-HSA-9824999 \"GSK3B phosphorylates p-S73 MITF-M at residue S69\"", "Reactome:R-HSA-9825704 \"AKT3 phosphorylates TBX3\"", "Reactome:R-HSA-9831514 \"CK2 phosphorylates nascent P\"", "Reactome:R-HSA-9831712 \"M dimer is phosphorylated\"", "Reactome:R-HSA-9832782 \"p-S232-S237-P is further phosphorylated\"", "Reactome:R-HSA-9834076 \"PINK1 is autophosphorylated\"", "Reactome:R-HSA-9834945 \"PINK1 phosphorylates Ub on MOM proteins\"", "Reactome:R-HSA-9835011 \"PINK1 phosphorylates PRKN at S65\"", "Reactome:R-HSA-9839363 \"TGFBR3 phosphorylation by TGFBR2 complex\"", "Reactome:R-HSA-9851972 \"PLK1 phosphorylates FIRRM at S43\"", "Reactome:R-HSA-9853369 \"PLK1 phosphorylates FIRMM at S744\"", "Reactome:R-HSA-9855910 \"USF1 is phosphorylated by p-MAPK14\"", "Reactome:R-HSA-9857661 \"p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43)\"", "Reactome:R-HSA-9857673 \"p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)\"", "Reactome:R-HSA-9860292 \"Activated IKBKB phosphorylates IRF5\"", "Reactome:R-HSA-9860785 \"PDPK1 (PDK1) phosphorylates PKN2 on threonine-816\"", "Reactome:R-HSA-9860800 \"mTORC2 phosphorylates AKT1 on serine-473\"", "Reactome:R-HSA-9861642 \"NEK1 phosphorylates ME1\"", "Reactome:R-HSA-9909369 \"CSNK1E,CSNK1D phosphorylate CRY and PER proteins\"", "Reactome:R-HSA-9912396 \"CDK5 phosphorylates CLOCK on serine-451 and serine-461\"", "Reactome:R-HSA-9912401 \"CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90\"", "Reactome:R-HSA-9920673 \"CDK5 phosphorylates PER2 on serine-396\"", "Reactome:R-HSA-9922273 \"CSNK1D,E phosphorylates CLOCK in p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL:p-2T,3S-CLOCK:target gene\"", "Reactome:R-HSA-9926483 \"MARK3 phosphorylates MITF-M on S173\"", "Reactome:R-HSA-9929360 \"GSK3B phosphorylates CD274\"", "Reactome:R-HSA-9931292 \"AMPK phosphorylates CD274\"", "Reactome:R-HSA-9931409 \"NEK2 phosphorylates CD274\"", "Reactome:R-HSA-9931418 \"CK2 phosphorylates CD274\"", "Reactome:R-HSA-9933380 \"Cytosolic tail of CDH1 is phosphorylated\"", "Reactome:R-HSA-9942578 \"Phosphorylation of CDC25A by p38 MAPK\"", "Reactome:R-HSA-9943662 \"CHEK1 phosphorylates NEK11\"", "Reactome:R-HSA-9943675 \"GSK3B phosphorylates CDC25A\"", "Reactome:R-HSA-9943676 \"NEK11 phosphorylates CDC25A\"", "Reactome:R-HSA-9943678 \"CHEK1 phosphorylates CHEK2-phosphorylated CDC25A\"", "Reactome:R-HSA-9943687 \"PLK3 phosphorylates CDC25A\"", "Reactome:R-HSA-9943736 \"Casein kinase I phosphorylates CDC25A\"", "Reactome:R-HSA-9954237 \"PIM1 phosphorylates GBP1\"" ] } } }, { "id": "GO:0004713", "name": "protein tyrosine kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.10.-", "MetaCyc:2.7.10.1-RXN", "Reactome:R-HSA-112333 \"SRC autophosphorylation is positively regulated by InlA-bound CDH1\"", "Reactome:R-HSA-114600 \"Fyn/Lyn-mediated phosphorylation of FcR1 gamma\"", "Reactome:R-HSA-1168394 \"STAT5 tyrosine phosphorylation\"", "Reactome:R-HSA-1169421 \"Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers\"", "Reactome:R-HSA-1225952 \"Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1225960 \"Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1247844 \"Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1248655 \"Trans-autophosphorylation of EGFRvIII mutant dimers\"", "Reactome:R-HSA-1248694 \"Trans-autophosphorylation of ERBB2 homodimer\"", "Reactome:R-HSA-1250195 \"SHC1 phosphorylation by ERBB2 heterodimers\"", "Reactome:R-HSA-1250315 \"Trans-autophosphorylation of ERBB4 homodimers\"", "Reactome:R-HSA-1250348 \"Phosphorylation of SHC1 by ERBB4 homodimers\"", "Reactome:R-HSA-1251922 \"PLCG1 phosphorylation by p-EGFR:p-ERBB2\"", "Reactome:R-HSA-1295540 \"IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5\"", "Reactome:R-HSA-1295609 \"SRC phosphorylates SPRY2 on Y55 and Y227\"", "Reactome:R-HSA-1307963 \"Autocatalytic phosphorylation of BetaKlotho-bound FGFR4\"", "Reactome:R-HSA-1433418 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-1433454 \"Phosphorylation of GAB2 by SFKs\"", "Reactome:R-HSA-1433488 \"Phosphorylation of SHP2 by SFKs\"", "Reactome:R-HSA-1433506 \"Phosphorylation of APS\"", "Reactome:R-HSA-1433542 \"Phosphorylation and activation of VAV1\"", "Reactome:R-HSA-1470009 \"Phosphorylation of STATs\"", "Reactome:R-HSA-1472121 \"Phosphorylation of p-KIT on Y900 by Src kinases\"", "Reactome:R-HSA-1524186 \"Phosphorylation of PLCgamma by PDGFR\"", "Reactome:R-HSA-1671691 \"PRLR-bound STAT5 is phosphorylated\"", "Reactome:R-HSA-170070 \"Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170156 \"WEE1 phosphorylates CCNA:CDK1\"", "Reactome:R-HSA-170991 \"SRC-1 autophosphorylates\"", "Reactome:R-HSA-171011 \"Binding and activation of MAP Kinase\"", "Reactome:R-HSA-174164 \"Phosphorylation of Cyclin A:Cdk2 at Tyr 15\"", "Reactome:R-HSA-177934 \"EGFR autophosphorylation\"", "Reactome:R-HSA-177937 \"Phosphorylation of EGFR by SRC kinase\"", "Reactome:R-HSA-182969 \"Phosphorylation of CBL (EGFR:CBL)\"", "Reactome:R-HSA-183058 \"Phosphorylation of CBL (EGFR:GRB2:CBL)\"", "Reactome:R-HSA-1839065 \"Phosphorylation of cytosolic FGFR1 fusion dimers\"", "Reactome:R-HSA-1839067 \"Phosphorylation of BCR moiety of BCR-FGFR1\"", "Reactome:R-HSA-1839098 \"Activated FGFR1 mutants and fusions phosphorylate PLCG1\"", "Reactome:R-HSA-1839110 \"p-BCR-p-FGFR1 phosphorylates GAB2\"", "Reactome:R-HSA-1839112 \"Phosphorylation of STAT5 by cytosolic FGFR1 fusions\"", "Reactome:R-HSA-186786 \"Autophosphorylation of PDGF beta receptors\"", "Reactome:R-HSA-1888198 \"FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3\"", "Reactome:R-HSA-190326 \"Autocatalytic phosphorylation of FGFR4\"", "Reactome:R-HSA-190385 \"Autocatalytic phosphorylation of FGFR3b\"", "Reactome:R-HSA-190388 \"Autocatalytic phosphorylation of FGFR3c\"", "Reactome:R-HSA-190408 \"Autocatalytic phosphorylation of FGFR2b\"", "Reactome:R-HSA-190413 \"Autocatalytic phosphorylation of FGFR2c\"", "Reactome:R-HSA-190427 \"Autocatalytic phosphorylation of FGFR1b\"", "Reactome:R-HSA-190429 \"Autocatalytic phosphorylation of FGFR1c\"", "Reactome:R-HSA-191062 \"Autocatalytic phosphorylation of Klotho-bound FGFR1c\"", "Reactome:R-HSA-191636 \"Phosphorylation of Cx43 by c-src\"", "Reactome:R-HSA-1963581 \"Trans-autophosphorylation of p-Y877-ERBB2 heterodimers\"", "Reactome:R-HSA-1963582 \"Trans-autophosphorylation of ERBB2 heterodimers\"", "Reactome:R-HSA-1963586 \"SRC family kinases phosphorylate ERBB2\"", "Reactome:R-HSA-1982066 \"Ligand-independent phosphorylation of overexpressed FGFR1\"", "Reactome:R-HSA-2012073 \"Autocatalytic phosphorylation of FGFR3c P250R mutant\"", "Reactome:R-HSA-2012082 \"Autocatalytic phosphorylation of FGFR3 cysteine mutants\"", "Reactome:R-HSA-2012087 \"Autocatalytic phosphorylation of FGFR4 Y367C mutant\"", "Reactome:R-HSA-201521 \"ALK autophosphorylation\"", "Reactome:R-HSA-202165 \"Phosphorylation of ITAM motifs in CD3 complexes\"", "Reactome:R-HSA-202168 \"Phosphorylation of ZAP-70 by Lck\"", "Reactome:R-HSA-202174 \"Activation of ZAP-70\"", "Reactome:R-HSA-202216 \"Phosphorylation of SLP-76\"", "Reactome:R-HSA-202233 \"Inactivation of Lck by Csk\"", "Reactome:R-HSA-202245 \"Phosphorylation of TBSMs in LAT\"", "Reactome:R-HSA-202248 \"Phosphorylation of PLC-gamma1\"", "Reactome:R-HSA-202291 \"Activation of Lck\"", "Reactome:R-HSA-202307 \"Change of PKC theta conformation\"", "Reactome:R-HSA-2023455 \"Autocatalytic phosphorylation of FGFR1c P252X mutant dimers\"", "Reactome:R-HSA-2023460 \"Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity\"", "Reactome:R-HSA-2029268 \"Phosphorylation and activation of PLCG\"", "Reactome:R-HSA-2029449 \"Phosphorylation of SYK by Src kinases\"", "Reactome:R-HSA-2029453 \"Phosphorylation of VAV\"", "Reactome:R-HSA-2029459 \"Sequestering and phosphorylation Fc gamma receptors in the lipid rafts\"", "Reactome:R-HSA-2029984 \"Autocatalytic phosphorylation of FGFR2 ligand-independent mutants\"", "Reactome:R-HSA-2029989 \"Autocatalytic phosphorylation of overexpressed FGFR2 variants\"", "Reactome:R-HSA-2033485 \"Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2033486 \"Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033488 \"Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033490 \"Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2038387 \"Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants\"", "Reactome:R-HSA-2038944 \"Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity\"", "Reactome:R-HSA-205289 \"Autophosphorylation of KIT\"", "Reactome:R-HSA-210291 \"Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src\"", "Reactome:R-HSA-210872 \"Trans-phosphorylation of Tie2\"", "Reactome:R-HSA-212710 \"EGFR activates PLC-gamma1 by phosphorylation\"", "Reactome:R-HSA-2130194 \"ABL phosphorylates WAVEs\"", "Reactome:R-HSA-2197698 \"Src phosphorylate WASP,N-WASP\"", "Reactome:R-HSA-2201322 \"TIRAP is phosphorylated by BTK\"", "Reactome:R-HSA-2395412 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2395439 \"Phosphorylation of DAP12\"", "Reactome:R-HSA-2395801 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2396594 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2404193 \"IGF1R phosphorylates SHC1\"", "Reactome:R-HSA-2404199 \"IGF1,2:IGF1R autophosphorylates\"", "Reactome:R-HSA-2424484 \"Phosphorylation of BTK by p-SYK\"", "Reactome:R-HSA-2424486 \"Phosphorylation and activation of VAV2/VAV3 by SYK\"", "Reactome:R-HSA-2424487 \"Phosphorylation of PLC-gamma by p-BTK/p-SYK\"", "Reactome:R-HSA-2428926 \"IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4\"", "Reactome:R-HSA-2454208 \"Phosphorylation of beta and gamma subunits by LYN\"", "Reactome:R-HSA-2454239 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2586553 \"JAK2 Phosphorylates LEPR\"", "Reactome:R-HSA-2586555 \"JAK2 Autophosphorylates in Response to Leptin\"", "Reactome:R-HSA-2671742 \"JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin\"", "Reactome:R-HSA-2671829 \"JAK2 Phosphorylates STAT5 in Response to Leptin\"", "Reactome:R-HSA-2671850 \"JAK2 Phosphoryates STAT3 in Response to Leptin\"", "Reactome:R-HSA-2730833 \"Phosphorylation of TEC kinases by p-SYK\"", "Reactome:R-HSA-2730843 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2730851 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2730858 \"Autophosphorylation of BTK/ITK\"", "Reactome:R-HSA-2730860 \"Phosphorylation of GAB2 by SYK/FYN\"", "Reactome:R-HSA-2730862 \"Autophosphorylation of LYN kinase\"", "Reactome:R-HSA-2730882 \"Phosphorylation of PKC-theta\"", "Reactome:R-HSA-2730884 \"Phosphorylation of NTAL by p-SYK/Lyn\"", "Reactome:R-HSA-2730886 \"Phosphorylation of SHC by SYK kinase\"", "Reactome:R-HSA-2730888 \"Phosphorylation of PLC-gamma\"", "Reactome:R-HSA-3215391 \"PRMT5 is tyrosine phosphorylated by JAK2 V617F\"", "Reactome:R-HSA-354073 \"Autophosphorylation of PTK2 at Y397\"", "Reactome:R-HSA-354124 \"Phosphorylation of pPTK2 by SRC\"", "Reactome:R-HSA-372693 \"Phosphorylation of BCAR1 by SRC-PTK2 complex\"", "Reactome:R-HSA-373747 \"Phosphorylation of nephrin by FYN\"", "Reactome:R-HSA-373750 \"SEMA4D interacts with Plexin-B1:ErbB2\"", "Reactome:R-HSA-374701 \"Phosphorylation of DCC by Fyn\"", "Reactome:R-HSA-377640 \"Autophosphorylation of SRC\"", "Reactome:R-HSA-380780 \"Activation of Src\"", "Reactome:R-HSA-388831 \"Phosphorylation of CD28\"", "Reactome:R-HSA-388833 \"Phosphorylation of CTLA-4\"", "Reactome:R-HSA-389083 \"Autophosphorylation of PDGF alpha receptors\"", "Reactome:R-HSA-389086 \"Autophosphorylation of PDGF alpha/beta receptors\"", "Reactome:R-HSA-389159 \"CSF1R trans-autophosphorylates on multiple tyrosine and serine residues\"", "Reactome:R-HSA-389354 \"Activation of Vav1\"", "Reactome:R-HSA-389762 \"Phosphorylation of PD-1\"", "Reactome:R-HSA-391156 \"Phosphorylation of ITIM motif in SIRP alpha\"", "Reactome:R-HSA-391865 \"Recruitment of FAK to NCAM1:Fyn in lipid rafts\"", "Reactome:R-HSA-391866 \"Phosphorylation of FAK by Src kinase\"", "Reactome:R-HSA-391871 \"Autophosphorylation of NCAM1 bound Fyn\"", "Reactome:R-HSA-3928578 \"EPH receptors autophosphorylate\"", "Reactome:R-HSA-3928580 \"SFKs phosphorylate EFNBs\"", "Reactome:R-HSA-3928583 \"FYN phosphorylates NMDAR2B\"", "Reactome:R-HSA-3928594 \"SFKs phosphorylate GIT1\"", "Reactome:R-HSA-3928604 \"SFKs phosphorylate VAV2,3\"", "Reactome:R-HSA-3928610 \"PTK2 autophosphorylates at Y397\"", "Reactome:R-HSA-3928627 \"EPHB phosphorylates TIAM1\"", "Reactome:R-HSA-3928648 \"SFKs phosphorylate NGEF\"", "Reactome:R-HSA-399934 \"Phosphorylation of Plexin-A\"", "Reactome:R-HSA-399946 \"Recruitment and activation of Cdk5\"", "Reactome:R-HSA-399947 \"Tyrosine phosphorylation of CRMPs by Fes\"", "Reactome:R-HSA-4093332 \"p-EPHB phosphorylates SDC2\"", "Reactome:R-HSA-418163 \"Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)\"", "Reactome:R-HSA-418859 \"Phosphorylation of Unc5C\"", "Reactome:R-HSA-418872 \"Phosphorylation of FADK1\"", "Reactome:R-HSA-419646 \"SEMA4D interacts with Plexin-B1:Met\"", "Reactome:R-HSA-428888 \"Phosphorylation of ROBO1 by ABL kinase\"", "Reactome:R-HSA-429441 \"SYK activation by SRC\"", "Reactome:R-HSA-429449 \"Syk activation leads to SLP-76 activation\"", "Reactome:R-HSA-432129 \"FGR binds and phosphorylates LRP8\"", "Reactome:R-HSA-434836 \"Syk/Lck phosphorylate LAT\"", "Reactome:R-HSA-4420117 \"VEGFR2 autophosphorylates\"", "Reactome:R-HSA-4420121 \"SFKs phosphorylate PLCG1\"", "Reactome:R-HSA-4420128 \"SRC-1 phosphorylates SHB\"", "Reactome:R-HSA-4420206 \"Phosphorylation of SRC-1\"", "Reactome:R-HSA-443817 \"Phosphorylation of L1 by EPHB2\"", "Reactome:R-HSA-445076 \"Phosphorylation of Y1229 in L1\"", "Reactome:R-HSA-445084 \"Phosphorylation of L1 by SRC\"", "Reactome:R-HSA-445085 \"Phosphorylation of VAV2\"", "Reactome:R-HSA-445091 \"Phosphorylation of Neurofascin\"", "Reactome:R-HSA-451942 \"Within the IL-2R complex JAK3 phosphorylates JAK1\"", "Reactome:R-HSA-452097 \"Recruited STAT5 is phosphorylated\"", "Reactome:R-HSA-452100 \"SHC1 bound to IL2 receptor is phosphorylated\"", "Reactome:R-HSA-452122 \"JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB\"", "Reactome:R-HSA-508282 \"SYK is a substrate for JAK1\"", "Reactome:R-HSA-5218640 \"SRC-1 phosphorylates p-Y397-PTK2\"", "Reactome:R-HSA-5218642 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-5218806 \"FYN autophosphorylates\"", "Reactome:R-HSA-5218809 \"PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118\"", "Reactome:R-HSA-5218812 \"FYN phosphorylates PAK2\"", "Reactome:R-HSA-5218820 \"Src kinases phosphorylate VAV\"", "Reactome:R-HSA-5218828 \"PTK2/SRC-1 phosphorylates BCAR1\"", "Reactome:R-HSA-5218830 \"SRC-1 phosphorylates PTK2-beta\"", "Reactome:R-HSA-5218851 \"p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407\"", "Reactome:R-HSA-5357429 \"AXL autophosphorylates on Y779 and Y821\"", "Reactome:R-HSA-5607745 \"1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG\"", "Reactome:R-HSA-5607750 \"SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan\"", "Reactome:R-HSA-5621355 \"LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG\"", "Reactome:R-HSA-5621363 \"SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2\"", "Reactome:R-HSA-5621370 \"SYK autophosphorylates\"", "Reactome:R-HSA-5624486 \"SFKs phosphorylates RAF1 on Y340,Y341\"", "Reactome:R-HSA-5637795 \"Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant\"", "Reactome:R-HSA-5637796 \"Phosphorylation of SHC1 by p-5Y-EGFRvIII\"", "Reactome:R-HSA-5654147 \"Activated FGFR2 phosphorylates PLCG1\"", "Reactome:R-HSA-5654149 \"Activated FGFR1 phosphorylates PLCG1\"", "Reactome:R-HSA-5654151 \"Activated FGFR4 phosphorylates PLCG1\"", "Reactome:R-HSA-5654222 \"Activated FGFR3 phosphorylates PLCG1\"", "Reactome:R-HSA-5654397 \"Activated FGFR2 phosphorylates FRS2\"", "Reactome:R-HSA-5654407 \"Activated FGFR2 phosphorylates SHC1\"", "Reactome:R-HSA-5654408 \"Activated FGFR3 phosphorylates FRS2\"", "Reactome:R-HSA-5654418 \"Activated FGFR4 phosphorylates FRS2\"", "Reactome:R-HSA-5654428 \"Activated FGFR4 phosphorylates SHC1\"", "Reactome:R-HSA-5654545 \"Ligand-independent phosphorylation of overexpressed FGFR1c\"", "Reactome:R-HSA-5654575 \"Activated FGFR1 phosphorylates FRS2\"", "Reactome:R-HSA-5654578 \"Activated FGFR1 phosphorylates FRS3\"", "Reactome:R-HSA-5654582 \"Activated FGFR1 phosphorylates SHC1\"", "Reactome:R-HSA-5654587 \"Activated FGFR1:p-FRS phosphorylates PPTN11\"", "Reactome:R-HSA-5654605 \"Activated FGFR2 phosphorylates FRS3\"", "Reactome:R-HSA-5654607 \"Activated FGFR2 phosphorylates PPTN11\"", "Reactome:R-HSA-5654628 \"Activated FGFR3 phosphorylates FRS3\"", "Reactome:R-HSA-5654631 \"Activated FGFR3 phosphorylates PPTN11\"", "Reactome:R-HSA-5654634 \"Activated FGFR3 phosphorylates SHC1\"", "Reactome:R-HSA-5654653 \"Activated FGFR4 phosphorylates FRS3\"", "Reactome:R-HSA-5654655 \"Activated FGFR4 phosphorylates PPTN11\"", "Reactome:R-HSA-5655243 \"Activated FGFR3 point and translocation mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655268 \"Activated FGFR2 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655270 \"Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655278 \"Activated FGFR1 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655284 \"Activated FGFR4 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655301 \"Activated FGFR2 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655341 \"Activated FGFR4 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5683930 \"WICH phosphorylates H2AFX on Y142\"", "Reactome:R-HSA-5686587 \"ABL1 phosphorylates RAD52\"", "Reactome:R-HSA-5690702 \"LYN phosphorylates CD22\"", "Reactome:R-HSA-6784006 \"STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2\"", "Reactome:R-HSA-6784319 \"JAK1,TYK2 phosphorylate JAK1,TYK2\"", "Reactome:R-HSA-6790087 \"HVEM induses BTLA phosphorylation\"", "Reactome:R-HSA-6806974 \"MET dimers autophosphorylate\"", "Reactome:R-HSA-68954 \"Mcm2-7 is phosphorylated by DDK\"", "Reactome:R-HSA-69195 \"Phosphorylation of Cyclin E:CDK2 complexes by WEE1\"", "Reactome:R-HSA-873918 \"Transphosphorylation of JAK1\"", "Reactome:R-HSA-873919 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-873922 \"Phosphorylation of STAT1 by JAK kinases\"", "Reactome:R-HSA-873924 \"Phosphorylation of IFNGR1 by JAK kinases\"", "Reactome:R-HSA-879907 \"Tyrosine kinases phosphorylate the receptor\"", "Reactome:R-HSA-879909 \"Activation of STAT5a/b by JAK2\"", "Reactome:R-HSA-879925 \"SHC1 bound to the common beta chain becomes tyrosine phosphorylated\"", "Reactome:R-HSA-8847977 \"FRK phosphorylates PTEN\"", "Reactome:R-HSA-8848005 \"ERBB2 promotes PTK6 autophosphorylation\"", "Reactome:R-HSA-8848077 \"PTK6 phosphorylates STAP2\"", "Reactome:R-HSA-8848124 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-8848436 \"PTK6 phosphorylates CDKN1B\"", "Reactome:R-HSA-8848606 \"PTK6 phosphorylates PXN\"", "Reactome:R-HSA-8848726 \"PTK6 phosphorylates BCAR1\"", "Reactome:R-HSA-8848758 \"PTK6 phosphorylates AKT1\"", "Reactome:R-HSA-8848776 \"PTK6 phosphorylates DOK1\"", "Reactome:R-HSA-8848818 \"PTK6 phosphorylates CBL\"", "Reactome:R-HSA-8848873 \"PTK6 phosphorylates ARAP1\"", "Reactome:R-HSA-8848975 \"PTK6 phosphorylates KHDRBS1\"", "Reactome:R-HSA-8849032 \"PTK6 phosphorylates KHDRBS2\"", "Reactome:R-HSA-8849042 \"PTK6 phosphorylates KHDRBS3\"", "Reactome:R-HSA-8849068 \"PTK6 phosphorylates ARHGAP35\"", "Reactome:R-HSA-8849102 \"SRMS phosphorylates PTK6\"", "Reactome:R-HSA-8849463 \"PTK6 phosphorylates SFPQ\"", "Reactome:R-HSA-8851890 \"MET phosphorylates SHC1-2\"", "Reactome:R-HSA-8851933 \"MET phosphorylates GAB1\"", "Reactome:R-HSA-8853309 \"Autocatalytic phosphorylation of FGFR3 fusions\"", "Reactome:R-HSA-8853313 \"FGFR2 fusions autophosphorylate\"", "Reactome:R-HSA-8853325 \"Plasma membrane FGFR1 fusions autophosphorylate\"", "Reactome:R-HSA-8855237 \"FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1\"", "Reactome:R-HSA-8857555 \"EGFR phosphorylates GPNMB\"", "Reactome:R-HSA-8857577 \"LINC01139 facilitates PTK6 autophosphorylation\"", "Reactome:R-HSA-8857583 \"LINC01139 promotes phosphorylation of HIF1A by PTK6\"", "Reactome:R-HSA-8857925 \"Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307\"", "Reactome:R-HSA-8867041 \"EGFR phosphorylates EPS15\"", "Reactome:R-HSA-8874078 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-8874080 \"SRC phosphorylates PTK2\"", "Reactome:R-HSA-8874082 \"MET phosphorylates PTK2\"", "Reactome:R-HSA-8875451 \"MET phosphorylates CBL\"", "Reactome:R-HSA-8875817 \"MET phosphorylates STAT3\"", "Reactome:R-HSA-8876230 \"InlB:MET dimer trans-autophophorylates\"", "Reactome:R-HSA-8876246 \"InlB-activated MET phosphorylates CBL\"", "Reactome:R-HSA-8876948 \"SRC phosphorylates InlA-bound CDH1 and CTNNB1\"", "Reactome:R-HSA-8937728 \"SRC phosphorylates RUNX1\"", "Reactome:R-HSA-8937807 \"SRC phosphorylates RUNX3\"", "Reactome:R-HSA-8937844 \"SRC,YES1 phosphorylate YAP1\"", "Reactome:R-HSA-8942607 \"Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes\"", "Reactome:R-HSA-8948143 \"p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18\"", "Reactome:R-HSA-8956659 \"ABL1 phosphorylates YAP1\"", "Reactome:R-HSA-8964242 \"G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8964252 \"G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8983872 \"JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4\"", "Reactome:R-HSA-9006323 \"Phospho-JAK2 phosphorylates EPOR\"", "Reactome:R-HSA-9006332 \"JAK2 transphosphorylates and is activated in response to Erythropoietin\"", "Reactome:R-HSA-9011241 \"SRC phosphorylates ROBO3.1 in response to NTN1\"", "Reactome:R-HSA-9012650 \"JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2\"", "Reactome:R-HSA-9018572 \"EGFR phosphorylates NOTCH3\"", "Reactome:R-HSA-9021609 \"ESR-associated SRC autophosphorylates\"", "Reactome:R-HSA-9024726 \"LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1\"", "Reactome:R-HSA-9026464 \"BDNF-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026502 \"NTF3-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026510 \"NTF4-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026579 \"NTRK2 phosphorylates PLCG1\"", "Reactome:R-HSA-9026890 \"NTRK2 phosphorylates SHC1\"", "Reactome:R-HSA-9027272 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2\"", "Reactome:R-HSA-9027273 \"JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1\"", "Reactome:R-HSA-9027425 \"LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2\"", "Reactome:R-HSA-9028728 \"NTRK2 phosphorylates FRS2\"", "Reactome:R-HSA-9029151 \"JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1\"", "Reactome:R-HSA-9029155 \"JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1\"", "Reactome:R-HSA-9032426 \"NTRK2 phosphorylates FRS3\"", "Reactome:R-HSA-9032532 \"NTRK2-bound FYN autophosphorylates\"", "Reactome:R-HSA-9032601 \"FYN-mediated phosphorylation of GRIN2B\"", "Reactome:R-HSA-9032854 \"NTRK2 phosphorylates CDK5\"", "Reactome:R-HSA-9033284 \"NTRK2 promotes TIAM1 phosphorylation\"", "Reactome:R-HSA-9034714 \"NTRK3 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9034814 \"NTRK3 phosphorylates PLCG1\"", "Reactome:R-HSA-9034875 \"NTRK3 phosphorylates SHC1\"", "Reactome:R-HSA-9037040 \"SRC,FYN phosphorylate NTRK2\"", "Reactome:R-HSA-909718 \"Formation of p-STAT1 homodimer\"", "Reactome:R-HSA-909726 \"Phosphorylation of STAT1\"", "Reactome:R-HSA-909729 \"Activation of JAK kinases\"", "Reactome:R-HSA-909730 \"Phosphorylation of INFAR1 by TYK2\"", "Reactome:R-HSA-909732 \"Phosphorylation of STAT2\"", "Reactome:R-HSA-912629 \"CBL is tyrosine phosphorylated\"", "Reactome:R-HSA-9603420 \"Activated NTRK3 promotes SRC autophosphorylation\"", "Reactome:R-HSA-9604767 \"FLT3LG dimer:FLT3 dimer autophosphorylates\"", "Reactome:R-HSA-9606159 \"BTK autophosphorylates\"", "Reactome:R-HSA-9606162 \"Phosphorylated BTK phosphorylates PLCG2\"", "Reactome:R-HSA-9606163 \"p-SYK and LYN phosphorylate BTK\"", "Reactome:R-HSA-9612085 \"SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs\"", "Reactome:R-HSA-9612996 \"NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9613023 \"NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9624014 \"SHC1 is phosphorylated downstream of estrogen stimulation of GPER1\"", "Reactome:R-HSA-9625487 \"PTK2 autophosphorylates downstream of EGFR\"", "Reactome:R-HSA-9634390 \"ERBB2 homodimer phosphorylates SHC1\"", "Reactome:R-HSA-9664261 \"Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK\"", "Reactome:R-HSA-9664275 \"Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers\"", "Reactome:R-HSA-9664278 \"Phosphorylation and activation of PLCG due to FCGR3A effect\"", "Reactome:R-HSA-9664588 \"ERBB2 KD mutants trans-autophosphorylate\"", "Reactome:R-HSA-9664976 \"Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665032 \"Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665389 \"Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate\"", "Reactome:R-HSA-9665411 \"Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665704 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665705 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665709 \"ERBB2 TMD/JMD heterodimers trans-autophosphorylate\"", "Reactome:R-HSA-9666425 \"p-6Y-SYK phosphorylates VAV1,2,3\"", "Reactome:R-HSA-9669890 \"Constitutive phosphorylation of kinase domain KIT mutants\"", "Reactome:R-HSA-9669911 \"Phosphorylation of juxtamembrane domain KIT mutants\"", "Reactome:R-HSA-9670412 \"Phosphorylation of STATs downstream of KIT mutants\"", "Reactome:R-HSA-9670418 \"Phosphorylation of JAK2 downstream of KIT mutants\"", "Reactome:R-HSA-9672173 \"Autophosphorylation of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672175 \"Autophosphorylation of PDGFR mutant dimers\"", "Reactome:R-HSA-9673756 \"Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins\"", "Reactome:R-HSA-9673761 \"Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB\"", "Reactome:R-HSA-9674558 \"p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1\"", "Reactome:R-HSA-9674567 \"p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2\"", "Reactome:R-HSA-9680248 \"Phosphorylation of extracellular domain KIT mutants\"", "Reactome:R-HSA-9695834 \"Constitutive phosphorylation of FLT3 mutants\"", "Reactome:R-HSA-9698003 \"FLT3 mutants phosphorylate GAB2\"", "Reactome:R-HSA-9698005 \"FLT3 ITD mutants phosphorylate STAT5\"", "Reactome:R-HSA-9699578 \"Active FLT3 phosphorylates CDKN1B\"", "Reactome:R-HSA-9700164 \"Active ALK phosphorylates FRS2\"", "Reactome:R-HSA-9700168 \"Active ALK phosphorylates IRS1\"", "Reactome:R-HSA-9700171 \"Active ALK phosphorylates PLCG1\"", "Reactome:R-HSA-9700175 \"Active ALK phosphorylates SHC1\"", "Reactome:R-HSA-9700181 \"Autophosphorylation of ALK fusions\"", "Reactome:R-HSA-9700186 \"Autophosphorylation of point mutants of ALK\"", "Reactome:R-HSA-9700193 \"ALK mutants phosphorylate SHC1\"", "Reactome:R-HSA-9700647 \"Active ALK phosphorylates SRC\"", "Reactome:R-HSA-9701488 \"Active ALK phosphorylates JAK3\"", "Reactome:R-HSA-9703437 \"FLT3 fusion dimers autophosphorylate\"", "Reactome:R-HSA-9703438 \"FLT3 fusions phosphorylate GAB2\"", "Reactome:R-HSA-9706344 \"FLT3 phosphorylates GRB10\"", "Reactome:R-HSA-9706350 \"FLT3 phosphorylates CBL\"", "Reactome:R-HSA-9709918 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-9712082 \"ALK fusions phosphorylate IRS1\"", "Reactome:R-HSA-9712085 \"ALK mutants phosphorylate STAT3\"", "Reactome:R-HSA-9712086 \"ALK fusions phosphorylate PLCG1\"", "Reactome:R-HSA-9712087 \"ALK fusions phosphorylate FRS\"", "Reactome:R-HSA-9726848 \"SRC phosphorylates RHOU\"", "Reactome:R-HSA-9732738 \"JAK1-mediated phosphorylation of RAF1\"", "Reactome:R-HSA-9733314 \"CSF1R trans-autophosphorylates on tyrosine-561\"", "Reactome:R-HSA-9733323 \"Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL\"", "Reactome:R-HSA-9762209 \"BACH1 is phosphorylated at tyrosine 483\"", "Reactome:R-HSA-982807 \"JAK2 phosphorylation of GHR\"", "Reactome:R-HSA-9831136 \"SH pentamer is phosphorylated\"", "Reactome:R-HSA-983703 \"p-6Y-SYK phosphorylates BLNK (SLP65)\"", "Reactome:R-HSA-983707 \"SYK autophosphorylates at the activated BCR\"", "Reactome:R-HSA-983709 \"LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)\"", "Reactome:R-HSA-9841924 \"ABL1 phosphorylates PPARG2\"", "Reactome:R-HSA-9842648 \"Autophosphorylation of LTK dimer:ALKAL1,2\"", "Reactome:R-HSA-9842651 \"Active LTK receptor phosphorylates SHC1\"", "Reactome:R-HSA-9842666 \"Active LTK phosphorylates IRS1\"", "Reactome:R-HSA-9842667 \"CLIP1-LTK fusion autophosphorylates\"", "Reactome:R-HSA-9860500 \"Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1\"", "Reactome:R-HSA-9860759 \"p-T816-PKN2 phosphorylates AKT1 on serine-308\"", "Reactome:R-HSA-9861469 \"p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)\"", "Reactome:R-HSA-9865196 \"p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1\"", "Reactome:R-HSA-9931290 \"IL6-activated JAK1 phosphorylates CD274\"", "Reactome:R-HSA-9934751 \"CDH1 is phosphorylated on tyrosine residues\"", "Reactome:R-HSA-9958871 \"Tyrosine phosphorylation of STAT3 by IL6 receptor\"", "Reactome:R-HSA-9958889 \"SRC phosphorylates CDH1\"", "Reactome:R-HSA-9958892 \"SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs\"", "RHEA:10596" ], "previous": [ "EC:2.7.10.-", "MetaCyc:2.7.10.1-RXN", "Reactome:R-HSA-112333 \"SRC autophosphorylation is positively regulated by InlA-bound CDH1\"", "Reactome:R-HSA-114600 \"Fyn/Lyn-mediated phosphorylation of FcR1 gamma\"", "Reactome:R-HSA-1168394 \"STAT5 tyrosine phosphorylation\"", "Reactome:R-HSA-1169421 \"Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers\"", "Reactome:R-HSA-1225952 \"Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1225960 \"Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1247844 \"Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants\"", "Reactome:R-HSA-1248655 \"Trans-autophosphorylation of EGFRvIII mutant dimers\"", "Reactome:R-HSA-1248694 \"Trans-autophosphorylation of ERBB2 homodimer\"", "Reactome:R-HSA-1250195 \"SHC1 phosphorylation by ERBB2 heterodimers\"", "Reactome:R-HSA-1250315 \"Trans-autophosphorylation of ERBB4 homodimers\"", "Reactome:R-HSA-1250348 \"Phosphorylation of SHC1 by ERBB4 homodimers\"", "Reactome:R-HSA-1251922 \"PLCG1 phosphorylation by p-EGFR:p-ERBB2\"", "Reactome:R-HSA-1295540 \"IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5\"", "Reactome:R-HSA-1295609 \"SRC phosphorylates SPRY2 on Y55 and Y227\"", "Reactome:R-HSA-1307963 \"Autocatalytic phosphorylation of BetaKlotho-bound FGFR4\"", "Reactome:R-HSA-1433418 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-1433454 \"Phosphorylation of GAB2 by SFKs\"", "Reactome:R-HSA-1433488 \"Phosphorylation of SHP2 by SFKs\"", "Reactome:R-HSA-1433506 \"Phosphorylation of APS\"", "Reactome:R-HSA-1433542 \"Phosphorylation and activation of VAV1\"", "Reactome:R-HSA-1470009 \"Phosphorylation of STATs\"", "Reactome:R-HSA-1472121 \"Phosphorylation of p-KIT on Y900 by Src kinases\"", "Reactome:R-HSA-1524186 \"Phosphorylation of PLCgamma by PDGFR\"", "Reactome:R-HSA-1671691 \"PRLR-bound STAT5 is phosphorylated\"", "Reactome:R-HSA-170070 \"Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes\"", "Reactome:R-HSA-170156 \"WEE1 phosphorylates CCNA:CDK1\"", "Reactome:R-HSA-170991 \"SRC-1 autophosphorylates\"", "Reactome:R-HSA-171011 \"Binding and activation of MAP Kinase\"", "Reactome:R-HSA-174164 \"Phosphorylation of Cyclin A:Cdk2 at Tyr 15\"", "Reactome:R-HSA-177934 \"EGFR autophosphorylation\"", "Reactome:R-HSA-177937 \"Phosphorylation of EGFR by SRC kinase\"", "Reactome:R-HSA-182969 \"Phosphorylation of CBL (EGFR:CBL)\"", "Reactome:R-HSA-183058 \"Phosphorylation of CBL (EGFR:GRB2:CBL)\"", "Reactome:R-HSA-1839065 \"Phosphorylation of cytosolic FGFR1 fusion dimers\"", "Reactome:R-HSA-1839067 \"Phosphorylation of BCR moiety of BCR-FGFR1\"", "Reactome:R-HSA-1839098 \"Activated FGFR1 mutants and fusions phosphorylate PLCG1\"", "Reactome:R-HSA-1839110 \"p-BCR-p-FGFR1 phosphorylates GAB2\"", "Reactome:R-HSA-1839112 \"Phosphorylation of STAT5 by cytosolic FGFR1 fusions\"", "Reactome:R-HSA-186786 \"Autophosphorylation of PDGF beta receptors\"", "Reactome:R-HSA-1888198 \"FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3\"", "Reactome:R-HSA-190326 \"Autocatalytic phosphorylation of FGFR4\"", "Reactome:R-HSA-190385 \"Autocatalytic phosphorylation of FGFR3b\"", "Reactome:R-HSA-190388 \"Autocatalytic phosphorylation of FGFR3c\"", "Reactome:R-HSA-190408 \"Autocatalytic phosphorylation of FGFR2b\"", "Reactome:R-HSA-190413 \"Autocatalytic phosphorylation of FGFR2c\"", "Reactome:R-HSA-190427 \"Autocatalytic phosphorylation of FGFR1b\"", "Reactome:R-HSA-190429 \"Autocatalytic phosphorylation of FGFR1c\"", "Reactome:R-HSA-191062 \"Autocatalytic phosphorylation of Klotho-bound FGFR1c\"", "Reactome:R-HSA-191636 \"Phosphorylation of Cx43 by c-src\"", "Reactome:R-HSA-1963581 \"Trans-autophosphorylation of p-Y877-ERBB2 heterodimers\"", "Reactome:R-HSA-1963582 \"Trans-autophosphorylation of ERBB2 heterodimers\"", "Reactome:R-HSA-1963586 \"SRC family kinases phosphorylate ERBB2\"", "Reactome:R-HSA-1982066 \"Ligand-independent phosphorylation of overexpressed FGFR1\"", "Reactome:R-HSA-2012073 \"Autocatalytic phosphorylation of FGFR3c P250R mutant\"", "Reactome:R-HSA-2012082 \"Autocatalytic phosphorylation of FGFR3 cysteine mutants\"", "Reactome:R-HSA-2012087 \"Autocatalytic phosphorylation of FGFR4 Y367C mutant\"", "Reactome:R-HSA-201521 \"ALK autophosphorylation\"", "Reactome:R-HSA-202165 \"Phosphorylation of ITAM motifs in CD3 complexes\"", "Reactome:R-HSA-202168 \"Phosphorylation of ZAP-70 by Lck\"", "Reactome:R-HSA-202174 \"Activation of ZAP-70\"", "Reactome:R-HSA-202216 \"Phosphorylation of SLP-76\"", "Reactome:R-HSA-202233 \"Inactivation of Lck by Csk\"", "Reactome:R-HSA-202245 \"Phosphorylation of TBSMs in LAT\"", "Reactome:R-HSA-202248 \"Phosphorylation of PLC-gamma1\"", "Reactome:R-HSA-202291 \"Activation of Lck\"", "Reactome:R-HSA-202307 \"Change of PKC theta conformation\"", "Reactome:R-HSA-2023455 \"Autocatalytic phosphorylation of FGFR1c P252X mutant dimers\"", "Reactome:R-HSA-2023460 \"Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity\"", "Reactome:R-HSA-2029268 \"Phosphorylation and activation of PLCG\"", "Reactome:R-HSA-2029449 \"Phosphorylation of SYK by Src kinases\"", "Reactome:R-HSA-2029453 \"Phosphorylation of VAV\"", "Reactome:R-HSA-2029459 \"Sequestering and phosphorylation Fc gamma receptors in the lipid rafts\"", "Reactome:R-HSA-2029984 \"Autocatalytic phosphorylation of FGFR2 ligand-independent mutants\"", "Reactome:R-HSA-2029989 \"Autocatalytic phosphorylation of overexpressed FGFR2 variants\"", "Reactome:R-HSA-2033485 \"Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2033486 \"Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033488 \"Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding\"", "Reactome:R-HSA-2033490 \"Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity\"", "Reactome:R-HSA-2038387 \"Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants\"", "Reactome:R-HSA-2038944 \"Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity\"", "Reactome:R-HSA-205289 \"Autophosphorylation of KIT\"", "Reactome:R-HSA-210291 \"Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src\"", "Reactome:R-HSA-210872 \"Trans-phosphorylation of Tie2\"", "Reactome:R-HSA-212710 \"EGFR activates PLC-gamma1 by phosphorylation\"", "Reactome:R-HSA-2130194 \"ABL phosphorylates WAVEs\"", "Reactome:R-HSA-2197698 \"Src phosphorylate WASP,N-WASP\"", "Reactome:R-HSA-2201322 \"TIRAP is phosphorylated by BTK\"", "Reactome:R-HSA-2395412 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2395439 \"Phosphorylation of DAP12\"", "Reactome:R-HSA-2395801 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2396594 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2404193 \"IGF1R phosphorylates SHC1\"", "Reactome:R-HSA-2404199 \"IGF1,2:IGF1R autophosphorylates\"", "Reactome:R-HSA-2424484 \"Phosphorylation of BTK by p-SYK\"", "Reactome:R-HSA-2424486 \"Phosphorylation and activation of VAV2/VAV3 by SYK\"", "Reactome:R-HSA-2424487 \"Phosphorylation of PLC-gamma by p-BTK/p-SYK\"", "Reactome:R-HSA-2428926 \"IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4\"", "Reactome:R-HSA-2454208 \"Phosphorylation of beta and gamma subunits by LYN\"", "Reactome:R-HSA-2454239 \"Phosphorylation of SYK\"", "Reactome:R-HSA-2586553 \"JAK2 Phosphorylates LEPR\"", "Reactome:R-HSA-2586555 \"JAK2 Autophosphorylates in Response to Leptin\"", "Reactome:R-HSA-2671742 \"JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin\"", "Reactome:R-HSA-2671829 \"JAK2 Phosphorylates STAT5 in Response to Leptin\"", "Reactome:R-HSA-2671850 \"JAK2 Phosphoryates STAT3 in Response to Leptin\"", "Reactome:R-HSA-2730833 \"Phosphorylation of TEC kinases by p-SYK\"", "Reactome:R-HSA-2730843 \"Phosphorylation of LAT by p-SYK\"", "Reactome:R-HSA-2730851 \"Phosphorylation of SLP-76 by p-SYK\"", "Reactome:R-HSA-2730858 \"Autophosphorylation of BTK/ITK\"", "Reactome:R-HSA-2730860 \"Phosphorylation of GAB2 by SYK/FYN\"", "Reactome:R-HSA-2730862 \"Autophosphorylation of LYN kinase\"", "Reactome:R-HSA-2730882 \"Phosphorylation of PKC-theta\"", "Reactome:R-HSA-2730884 \"Phosphorylation of NTAL by p-SYK/Lyn\"", "Reactome:R-HSA-2730886 \"Phosphorylation of SHC by SYK kinase\"", "Reactome:R-HSA-2730888 \"Phosphorylation of PLC-gamma\"", "Reactome:R-HSA-3215391 \"PRMT5 is tyrosine phosphorylated by JAK2 V617F\"", "Reactome:R-HSA-354073 \"Autophosphorylation of PTK2 at Y397\"", "Reactome:R-HSA-354124 \"Phosphorylation of pPTK2 by SRC\"", "Reactome:R-HSA-372693 \"Phosphorylation of BCAR1 by SRC-PTK2 complex\"", "Reactome:R-HSA-373747 \"Phosphorylation of nephrin by FYN\"", "Reactome:R-HSA-373750 \"SEMA4D interacts with Plexin-B1:ErbB2\"", "Reactome:R-HSA-374701 \"Phosphorylation of DCC by Fyn\"", "Reactome:R-HSA-377640 \"Autophosphorylation of SRC\"", "Reactome:R-HSA-380780 \"Activation of Src\"", "Reactome:R-HSA-388831 \"Phosphorylation of CD28\"", "Reactome:R-HSA-388833 \"Phosphorylation of CTLA-4\"", "Reactome:R-HSA-389083 \"Autophosphorylation of PDGF alpha receptors\"", "Reactome:R-HSA-389086 \"Autophosphorylation of PDGF alpha/beta receptors\"", "Reactome:R-HSA-389159 \"CSF1R trans-autophosphorylates on multiple tyrosine and serine residues\"", "Reactome:R-HSA-389354 \"Activation of Vav1\"", "Reactome:R-HSA-389762 \"Phosphorylation of PD-1\"", "Reactome:R-HSA-391156 \"Phosphorylation of ITIM motif in SIRP alpha\"", "Reactome:R-HSA-391865 \"Recruitment of FAK to NCAM1:Fyn in lipid rafts\"", "Reactome:R-HSA-391866 \"Phosphorylation of FAK by Src kinase\"", "Reactome:R-HSA-391871 \"Autophosphorylation of NCAM1 bound Fyn\"", "Reactome:R-HSA-3928578 \"EPH receptors autophosphorylate\"", "Reactome:R-HSA-3928580 \"SFKs phosphorylate EFNBs\"", "Reactome:R-HSA-3928583 \"FYN phosphorylates NMDAR2B\"", "Reactome:R-HSA-3928594 \"SFKs phosphorylate GIT1\"", "Reactome:R-HSA-3928604 \"SFKs phosphorylate VAV2,3\"", "Reactome:R-HSA-3928610 \"PTK2 autophosphorylates at Y397\"", "Reactome:R-HSA-3928627 \"EPHB phosphorylates TIAM1\"", "Reactome:R-HSA-3928648 \"SFKs phosphorylate NGEF\"", "Reactome:R-HSA-399934 \"Phosphorylation of Plexin-A\"", "Reactome:R-HSA-399946 \"Recruitment and activation of Cdk5\"", "Reactome:R-HSA-399947 \"Tyrosine phosphorylation of CRMPs by Fes\"", "Reactome:R-HSA-4093332 \"p-EPHB phosphorylates SDC2\"", "Reactome:R-HSA-418163 \"Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)\"", "Reactome:R-HSA-418859 \"Phosphorylation of Unc5C\"", "Reactome:R-HSA-418872 \"Phosphorylation of FADK1\"", "Reactome:R-HSA-419646 \"SEMA4D interacts with Plexin-B1:Met\"", "Reactome:R-HSA-428888 \"Phosphorylation of ROBO1 by ABL kinase\"", "Reactome:R-HSA-429441 \"SYK activation by SRC\"", "Reactome:R-HSA-429449 \"Syk activation leads to SLP-76 activation\"", "Reactome:R-HSA-432129 \"FGR binds and phosphorylates LRP8\"", "Reactome:R-HSA-434836 \"Syk/Lck phosphorylate LAT\"", "Reactome:R-HSA-4420117 \"VEGFR2 autophosphorylates\"", "Reactome:R-HSA-4420121 \"SFKs phosphorylate PLCG1\"", "Reactome:R-HSA-4420128 \"SRC-1 phosphorylates SHB\"", "Reactome:R-HSA-4420206 \"Phosphorylation of SRC-1\"", "Reactome:R-HSA-443817 \"Phosphorylation of L1 by EPHB2\"", "Reactome:R-HSA-445076 \"Phosphorylation of Y1229 in L1\"", "Reactome:R-HSA-445084 \"Phosphorylation of L1 by SRC\"", "Reactome:R-HSA-445085 \"Phosphorylation of VAV2\"", "Reactome:R-HSA-445091 \"Phosphorylation of Neurofascin\"", "Reactome:R-HSA-451942 \"Within the IL-2R complex JAK3 phosphorylates JAK1\"", "Reactome:R-HSA-452097 \"Recruited STAT5 is phosphorylated\"", "Reactome:R-HSA-452100 \"SHC1 bound to IL2 receptor is phosphorylated\"", "Reactome:R-HSA-452122 \"JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB\"", "Reactome:R-HSA-508282 \"SYK is a substrate for JAK1\"", "Reactome:R-HSA-5218640 \"SRC-1 phosphorylates p-Y397-PTK2\"", "Reactome:R-HSA-5218642 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-5218806 \"FYN autophosphorylates\"", "Reactome:R-HSA-5218809 \"PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118\"", "Reactome:R-HSA-5218812 \"FYN phosphorylates PAK2\"", "Reactome:R-HSA-5218820 \"Src kinases phosphorylate VAV\"", "Reactome:R-HSA-5218828 \"PTK2/SRC-1 phosphorylates BCAR1\"", "Reactome:R-HSA-5218830 \"SRC-1 phosphorylates PTK2-beta\"", "Reactome:R-HSA-5218851 \"p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407\"", "Reactome:R-HSA-5357429 \"AXL autophosphorylates on Y779 and Y821\"", "Reactome:R-HSA-5607745 \"1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG\"", "Reactome:R-HSA-5607750 \"SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan\"", "Reactome:R-HSA-5621355 \"LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG\"", "Reactome:R-HSA-5621363 \"SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2\"", "Reactome:R-HSA-5621370 \"SYK autophosphorylates\"", "Reactome:R-HSA-5624486 \"SFKs phosphorylates RAF1 on Y340,Y341\"", "Reactome:R-HSA-5637795 \"Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant\"", "Reactome:R-HSA-5637796 \"Phosphorylation of SHC1 by p-5Y-EGFRvIII\"", "Reactome:R-HSA-5654147 \"Activated FGFR2 phosphorylates PLCG1\"", "Reactome:R-HSA-5654149 \"Activated FGFR1 phosphorylates PLCG1\"", "Reactome:R-HSA-5654151 \"Activated FGFR4 phosphorylates PLCG1\"", "Reactome:R-HSA-5654222 \"Activated FGFR3 phosphorylates PLCG1\"", "Reactome:R-HSA-5654397 \"Activated FGFR2 phosphorylates FRS2\"", "Reactome:R-HSA-5654407 \"Activated FGFR2 phosphorylates SHC1\"", "Reactome:R-HSA-5654408 \"Activated FGFR3 phosphorylates FRS2\"", "Reactome:R-HSA-5654418 \"Activated FGFR4 phosphorylates FRS2\"", "Reactome:R-HSA-5654428 \"Activated FGFR4 phosphorylates SHC1\"", "Reactome:R-HSA-5654545 \"Ligand-independent phosphorylation of overexpressed FGFR1c\"", "Reactome:R-HSA-5654575 \"Activated FGFR1 phosphorylates FRS2\"", "Reactome:R-HSA-5654578 \"Activated FGFR1 phosphorylates FRS3\"", "Reactome:R-HSA-5654582 \"Activated FGFR1 phosphorylates SHC1\"", "Reactome:R-HSA-5654587 \"Activated FGFR1:p-FRS phosphorylates PPTN11\"", "Reactome:R-HSA-5654605 \"Activated FGFR2 phosphorylates FRS3\"", "Reactome:R-HSA-5654607 \"Activated FGFR2 phosphorylates PPTN11\"", "Reactome:R-HSA-5654628 \"Activated FGFR3 phosphorylates FRS3\"", "Reactome:R-HSA-5654631 \"Activated FGFR3 phosphorylates PPTN11\"", "Reactome:R-HSA-5654634 \"Activated FGFR3 phosphorylates SHC1\"", "Reactome:R-HSA-5654653 \"Activated FGFR4 phosphorylates FRS3\"", "Reactome:R-HSA-5654655 \"Activated FGFR4 phosphorylates PPTN11\"", "Reactome:R-HSA-5655243 \"Activated FGFR3 point and translocation mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655268 \"Activated FGFR2 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655270 \"Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655278 \"Activated FGFR1 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655284 \"Activated FGFR4 mutants phosphorylate FRS2\"", "Reactome:R-HSA-5655301 \"Activated FGFR2 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5655341 \"Activated FGFR4 mutants phosphorylate PLCG1\"", "Reactome:R-HSA-5683930 \"WICH phosphorylates H2AFX on Y142\"", "Reactome:R-HSA-5686587 \"ABL1 phosphorylates RAD52\"", "Reactome:R-HSA-5690702 \"LYN phosphorylates CD22\"", "Reactome:R-HSA-6784006 \"STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2\"", "Reactome:R-HSA-6784319 \"JAK1,TYK2 phosphorylate JAK1,TYK2\"", "Reactome:R-HSA-6790087 \"HVEM induses BTLA phosphorylation\"", "Reactome:R-HSA-6806974 \"MET dimers autophosphorylate\"", "Reactome:R-HSA-68954 \"Mcm2-7 is phosphorylated by DDK\"", "Reactome:R-HSA-69195 \"Phosphorylation of Cyclin E:CDK2 complexes by WEE1\"", "Reactome:R-HSA-873918 \"Transphosphorylation of JAK1\"", "Reactome:R-HSA-873919 \"Phosphorylation of JAK2\"", "Reactome:R-HSA-873922 \"Phosphorylation of STAT1 by JAK kinases\"", "Reactome:R-HSA-873924 \"Phosphorylation of IFNGR1 by JAK kinases\"", "Reactome:R-HSA-879907 \"Tyrosine kinases phosphorylate the receptor\"", "Reactome:R-HSA-879909 \"Activation of STAT5a/b by JAK2\"", "Reactome:R-HSA-879925 \"SHC1 bound to the common beta chain becomes tyrosine phosphorylated\"", "Reactome:R-HSA-8847977 \"FRK phosphorylates PTEN\"", "Reactome:R-HSA-8848005 \"ERBB2 promotes PTK6 autophosphorylation\"", "Reactome:R-HSA-8848077 \"PTK6 phosphorylates STAP2\"", "Reactome:R-HSA-8848124 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-8848436 \"PTK6 phosphorylates CDKN1B\"", "Reactome:R-HSA-8848606 \"PTK6 phosphorylates PXN\"", "Reactome:R-HSA-8848726 \"PTK6 phosphorylates BCAR1\"", "Reactome:R-HSA-8848758 \"PTK6 phosphorylates AKT1\"", "Reactome:R-HSA-8848776 \"PTK6 phosphorylates DOK1\"", "Reactome:R-HSA-8848818 \"PTK6 phosphorylates CBL\"", "Reactome:R-HSA-8848873 \"PTK6 phosphorylates ARAP1\"", "Reactome:R-HSA-8848975 \"PTK6 phosphorylates KHDRBS1\"", "Reactome:R-HSA-8849032 \"PTK6 phosphorylates KHDRBS2\"", "Reactome:R-HSA-8849042 \"PTK6 phosphorylates KHDRBS3\"", "Reactome:R-HSA-8849068 \"PTK6 phosphorylates ARHGAP35\"", "Reactome:R-HSA-8849102 \"SRMS phosphorylates PTK6\"", "Reactome:R-HSA-8849463 \"PTK6 phosphorylates SFPQ\"", "Reactome:R-HSA-8851890 \"MET phosphorylates SHC1-2\"", "Reactome:R-HSA-8851933 \"MET phosphorylates GAB1\"", "Reactome:R-HSA-8853309 \"Autocatalytic phosphorylation of FGFR3 fusions\"", "Reactome:R-HSA-8853313 \"FGFR2 fusions autophosphorylate\"", "Reactome:R-HSA-8853325 \"Plasma membrane FGFR1 fusions autophosphorylate\"", "Reactome:R-HSA-8855237 \"FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1\"", "Reactome:R-HSA-8857555 \"EGFR phosphorylates GPNMB\"", "Reactome:R-HSA-8857577 \"LINC01139 facilitates PTK6 autophosphorylation\"", "Reactome:R-HSA-8857583 \"LINC01139 promotes phosphorylation of HIF1A by PTK6\"", "Reactome:R-HSA-8857925 \"Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307\"", "Reactome:R-HSA-8867041 \"EGFR phosphorylates EPS15\"", "Reactome:R-HSA-8874078 \"PTK2 autophosphorylates\"", "Reactome:R-HSA-8874080 \"SRC phosphorylates PTK2\"", "Reactome:R-HSA-8874082 \"MET phosphorylates PTK2\"", "Reactome:R-HSA-8875451 \"MET phosphorylates CBL\"", "Reactome:R-HSA-8875817 \"MET phosphorylates STAT3\"", "Reactome:R-HSA-8876230 \"InlB:MET dimer trans-autophophorylates\"", "Reactome:R-HSA-8876246 \"InlB-activated MET phosphorylates CBL\"", "Reactome:R-HSA-8876948 \"SRC phosphorylates InlA-bound CDH1 and CTNNB1\"", "Reactome:R-HSA-8937728 \"SRC phosphorylates RUNX1\"", "Reactome:R-HSA-8937807 \"SRC phosphorylates RUNX3\"", "Reactome:R-HSA-8937844 \"SRC,YES1 phosphorylate YAP1\"", "Reactome:R-HSA-8942607 \"Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes\"", "Reactome:R-HSA-8948143 \"p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18\"", "Reactome:R-HSA-8956659 \"ABL1 phosphorylates YAP1\"", "Reactome:R-HSA-8964242 \"G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8964252 \"G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC\"", "Reactome:R-HSA-8983872 \"JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4\"", "Reactome:R-HSA-9006323 \"Phospho-JAK2 phosphorylates EPOR\"", "Reactome:R-HSA-9006332 \"JAK2 transphosphorylates and is activated in response to Erythropoietin\"", "Reactome:R-HSA-9011241 \"SRC phosphorylates ROBO3.1 in response to NTN1\"", "Reactome:R-HSA-9012650 \"JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2\"", "Reactome:R-HSA-9018572 \"EGFR phosphorylates NOTCH3\"", "Reactome:R-HSA-9021609 \"ESR-associated SRC autophosphorylates\"", "Reactome:R-HSA-9024726 \"LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1\"", "Reactome:R-HSA-9026464 \"BDNF-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026502 \"NTF3-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026510 \"NTF4-bound NTRK2 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9026579 \"NTRK2 phosphorylates PLCG1\"", "Reactome:R-HSA-9026890 \"NTRK2 phosphorylates SHC1\"", "Reactome:R-HSA-9027272 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2\"", "Reactome:R-HSA-9027273 \"JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1\"", "Reactome:R-HSA-9027425 \"LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2\"", "Reactome:R-HSA-9028728 \"NTRK2 phosphorylates FRS2\"", "Reactome:R-HSA-9029151 \"JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1\"", "Reactome:R-HSA-9029155 \"JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1\"", "Reactome:R-HSA-9032426 \"NTRK2 phosphorylates FRS3\"", "Reactome:R-HSA-9032532 \"NTRK2-bound FYN autophosphorylates\"", "Reactome:R-HSA-9032601 \"FYN-mediated phosphorylation of GRIN2B\"", "Reactome:R-HSA-9032854 \"NTRK2 phosphorylates CDK5\"", "Reactome:R-HSA-9033284 \"NTRK2 promotes TIAM1 phosphorylation\"", "Reactome:R-HSA-9034714 \"NTRK3 dimers trans-autophosphorylate\"", "Reactome:R-HSA-9034814 \"NTRK3 phosphorylates PLCG1\"", "Reactome:R-HSA-9034875 \"NTRK3 phosphorylates SHC1\"", "Reactome:R-HSA-9037040 \"SRC,FYN phosphorylate NTRK2\"", "Reactome:R-HSA-909718 \"Formation of p-STAT1 homodimer\"", "Reactome:R-HSA-909726 \"Phosphorylation of STAT1\"", "Reactome:R-HSA-909729 \"Activation of JAK kinases\"", "Reactome:R-HSA-909730 \"Phosphorylation of INFAR1 by TYK2\"", "Reactome:R-HSA-909732 \"Phosphorylation of STAT2\"", "Reactome:R-HSA-912629 \"CBL is tyrosine phosphorylated\"", "Reactome:R-HSA-9603420 \"Activated NTRK3 promotes SRC autophosphorylation\"", "Reactome:R-HSA-9604767 \"FLT3LG dimer:FLT3 dimer autophosphorylates\"", "Reactome:R-HSA-9606159 \"BTK autophosphorylates\"", "Reactome:R-HSA-9606162 \"Phosphorylated BTK phosphorylates PLCG2\"", "Reactome:R-HSA-9606163 \"p-SYK and LYN phosphorylate BTK\"", "Reactome:R-HSA-9612085 \"SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs\"", "Reactome:R-HSA-9612996 \"NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9613023 \"NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates\"", "Reactome:R-HSA-9624014 \"SHC1 is phosphorylated downstream of estrogen stimulation of GPER1\"", "Reactome:R-HSA-9625487 \"PTK2 autophosphorylates downstream of EGFR\"", "Reactome:R-HSA-9634390 \"ERBB2 homodimer phosphorylates SHC1\"", "Reactome:R-HSA-9664261 \"Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK\"", "Reactome:R-HSA-9664275 \"Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers\"", "Reactome:R-HSA-9664278 \"Phosphorylation and activation of PLCG due to FCGR3A effect\"", "Reactome:R-HSA-9664588 \"ERBB2 KD mutants trans-autophosphorylate\"", "Reactome:R-HSA-9664976 \"Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665032 \"Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665389 \"Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate\"", "Reactome:R-HSA-9665411 \"Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665704 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1\"", "Reactome:R-HSA-9665705 \"Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1\"", "Reactome:R-HSA-9665709 \"ERBB2 TMD/JMD heterodimers trans-autophosphorylate\"", "Reactome:R-HSA-9666425 \"p-6Y-SYK phosphorylates VAV1,2,3\"", "Reactome:R-HSA-9669890 \"Constitutive phosphorylation of kinase domain KIT mutants\"", "Reactome:R-HSA-9669911 \"Phosphorylation of juxtamembrane domain KIT mutants\"", "Reactome:R-HSA-9670412 \"Phosphorylation of STATs downstream of KIT mutants\"", "Reactome:R-HSA-9670418 \"Phosphorylation of JAK2 downstream of KIT mutants\"", "Reactome:R-HSA-9672173 \"Autophosphorylation of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672175 \"Autophosphorylation of PDGFR mutant dimers\"", "Reactome:R-HSA-9673756 \"Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins\"", "Reactome:R-HSA-9673761 \"Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB\"", "Reactome:R-HSA-9674558 \"p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1\"", "Reactome:R-HSA-9674567 \"p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2\"", "Reactome:R-HSA-9680248 \"Phosphorylation of extracellular domain KIT mutants\"", "Reactome:R-HSA-9695834 \"Constitutive phosphorylation of FLT3 mutants\"", "Reactome:R-HSA-9698003 \"FLT3 mutants phosphorylate GAB2\"", "Reactome:R-HSA-9698005 \"FLT3 ITD mutants phosphorylate STAT5\"", "Reactome:R-HSA-9699578 \"Active FLT3 phosphorylates CDKN1B\"", "Reactome:R-HSA-9700164 \"Active ALK phosphorylates FRS2\"", "Reactome:R-HSA-9700168 \"Active ALK phosphorylates IRS1\"", "Reactome:R-HSA-9700171 \"Active ALK phosphorylates PLCG1\"", "Reactome:R-HSA-9700175 \"Active ALK phosphorylates SHC1\"", "Reactome:R-HSA-9700181 \"Autophosphorylation of ALK fusions\"", "Reactome:R-HSA-9700186 \"Autophosphorylation of point mutants of ALK\"", "Reactome:R-HSA-9700193 \"ALK mutants phosphorylate SHC1\"", "Reactome:R-HSA-9700647 \"Active ALK phosphorylates SRC\"", "Reactome:R-HSA-9701488 \"Active ALK phosphorylates JAK3\"", "Reactome:R-HSA-9703437 \"FLT3 fusion dimers autophosphorylate\"", "Reactome:R-HSA-9703438 \"FLT3 fusions phosphorylate GAB2\"", "Reactome:R-HSA-9706344 \"FLT3 phosphorylates GRB10\"", "Reactome:R-HSA-9706350 \"FLT3 phosphorylates CBL\"", "Reactome:R-HSA-9709918 \"PTK6 phosphorylates STAT3\"", "Reactome:R-HSA-9712082 \"ALK fusions phosphorylate IRS1\"", "Reactome:R-HSA-9712085 \"ALK mutants phosphorylate STAT3\"", "Reactome:R-HSA-9712086 \"ALK fusions phosphorylate PLCG1\"", "Reactome:R-HSA-9712087 \"ALK fusions phosphorylate FRS\"", "Reactome:R-HSA-9726848 \"SRC phosphorylates RHOU\"", "Reactome:R-HSA-9732738 \"JAK1-mediated phosphorylation of RAF1\"", "Reactome:R-HSA-9733314 \"CSF1R trans-autophosphorylates on tyrosine-561\"", "Reactome:R-HSA-9733323 \"Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL\"", "Reactome:R-HSA-9762209 \"BACH1 is phosphorylated at tyrosine 483\"", "Reactome:R-HSA-982807 \"JAK2 phosphorylation of GHR\"", "Reactome:R-HSA-9831136 \"SH pentamer is phosphorylated\"", "Reactome:R-HSA-983703 \"p-6Y-SYK phosphorylates BLNK (SLP65)\"", "Reactome:R-HSA-983707 \"SYK autophosphorylates at the activated BCR\"", "Reactome:R-HSA-983709 \"LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)\"", "Reactome:R-HSA-9841924 \"ABL1 phosphorylates PPARG2\"", "Reactome:R-HSA-9842648 \"Autophosphorylation of LTK dimer:ALKAL1,2\"", "Reactome:R-HSA-9842651 \"Active LTK receptor phosphorylates SHC1\"", "Reactome:R-HSA-9842666 \"Active LTK phosphorylates IRS1\"", "Reactome:R-HSA-9842667 \"CLIP1-LTK fusion autophosphorylates\"", "Reactome:R-HSA-9860500 \"Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1\"", "Reactome:R-HSA-9860759 \"p-T816-PKN2 phosphorylates AKT1 on serine-308\"", "Reactome:R-HSA-9861469 \"p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)\"", "Reactome:R-HSA-9865196 \"p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1\"", "Reactome:R-HSA-9931290 \"IL6-activated JAK1 phosphorylates CD274\"", "Reactome:R-HSA-9934751 \"CDH1 is phosphorylated on tyrosine residues\"", "RHEA:10596" ] } } }, { "id": "GO:0004722", "name": "protein serine/threonine phosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.16", "MetaCyc:3.1.3.16-RXN", "Reactome:R-HSA-1295632 \"PPA2A dephosphorylates SPRY2\"", "Reactome:R-HSA-163568 \"phosphorylated perilipin + H2O -> perilipin + orthophosphate\"", "Reactome:R-HSA-163689 \"PP2A complex dephosphorylates pChREBP (MLXIPL)\"", "Reactome:R-HSA-163750 \"PP2A complex dephosphorylates pPFKFB1\"", "Reactome:R-HSA-1638821 \"PP2A-B56 dephosphorylates centromeric cohesin\"", "Reactome:R-HSA-199425 \"PHLPP dephosphorylates S473 in AKT\"", "Reactome:R-HSA-199959 \"ERKs are inactivated by protein phosphatase 2A\"", "Reactome:R-HSA-201787 \"PPP3 complex dephosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-201790 \"DARPP-32 is dephosphorylated on Thr75 by PP2A\"", "Reactome:R-HSA-209055 \"PPM1A dephosphorylates nuclear SMAD2/3\"", "Reactome:R-HSA-2187401 \"MTMR4 dephosphorylates SMAD2/3\"", "Reactome:R-HSA-2995388 \"PP2A dephosphorylates BANF1\"", "Reactome:R-HSA-3002811 \"Myosin phosphatase dephosphorylates PLK1\"", "Reactome:R-HSA-3601585 \"PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex\"", "Reactome:R-HSA-380949 \"AMPK is dephosphorylated\"", "Reactome:R-HSA-4088141 \"PP2A-PPP2R2A dephosphorylates FOXM1\"", "Reactome:R-HSA-429730 \"PPM1L dephosphorylates multiphospho-CERT1-2\"", "Reactome:R-HSA-4419948 \"CTDNEP1:CNEP1R1 dephosphorylates LPIN\"", "Reactome:R-HSA-5672957 \"PP2A dephosphorylates KSR1\"", "Reactome:R-HSA-5672961 \"PP2A dephosphorylates inactive RAFs\"", "Reactome:R-HSA-5675431 \"PP2A dephosphorylates RAF1\"", "Reactome:R-HSA-5675433 \"PP5 dephosphorylates RAF1 S338\"", "Reactome:R-HSA-5679206 \"MTMR14, MTMR3 dephosphorylate PI3P\"", "Reactome:R-HSA-5683405 \"PPP5C dephosphorylates TP53BP1\"", "Reactome:R-HSA-5687758 \"PPP4C:PPP4R2 dephosphorylates RPA2\"", "Reactome:R-HSA-5692754 \"CDC14A,B dephosphorylate p-3S,T MAPK6\"", "Reactome:R-HSA-5694421 \"PP6 dephosphorylates SEC24\"", "Reactome:R-HSA-6792863 \"PP2A-PP2R5C dephosphorylates MDM2\"", "Reactome:R-HSA-6811504 \"AKT1 dephosphorylation by PP2A-B56-beta,gamma\"", "Reactome:R-HSA-74948 \"PP2A dephosphorylates p-RHO to RHO\"", "Reactome:R-HSA-8948139 \"p-S13-FUNDC1 is dephosphorylated by PGAM5\"", "Reactome:R-HSA-9619430 \"PPM1E dephosphorylates CAMK4\"", "Reactome:R-HSA-9619449 \"PPM1F dephosphorylates p-T286-CaMKII\"", "Reactome:R-HSA-9619467 \"PPM1F dephosphorylates CAMK1\"", "Reactome:R-HSA-9658445 \"MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs\"", "Reactome:R-HSA-9660536 \"SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex\"", "Reactome:R-HSA-9660538 \"Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs\"", "Reactome:R-HSA-9686524 \"PP6-PPP6R3 dephosphorylates TERF2\"", "Reactome:R-HSA-9831948 \"P:PP1 dephosphorylates M2-1\"", "Reactome:R-HSA-9853385 \"PPP1CC dephosphorylates PLK1\"", "Reactome:R-HSA-9861725 \"PGAM5 dodecamer dephosphorylates p-S336-ME1\"", "Reactome:R-HSA-9865226 \"PP2A dephosphorylates serine-127 of YAP1\"", "Reactome:R-HSA-9865238 \"PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin\"", "Reactome:R-HSA-9912527 \"H139Hfs13* PPM1K does not dephosphorylate BCKDH\"", "Reactome:R-HSA-9970190 \"PP1 dephosphorylates RNA Pol II\"", "RHEA:12849", "RHEA:20629", "RHEA:47004", "RHEA:53988" ], "previous": [ "EC:3.1.3.16", "MetaCyc:3.1.3.16-RXN", "Reactome:R-HSA-1295632 \"PPA2A dephosphorylates SPRY2\"", "Reactome:R-HSA-163568 \"phosphorylated perilipin + H2O -> perilipin + orthophosphate\"", "Reactome:R-HSA-163689 \"PP2A complex dephosphorylates pChREBP (MLXIPL)\"", "Reactome:R-HSA-163750 \"PP2A complex dephosphorylates pPFKFB1\"", "Reactome:R-HSA-1638821 \"PP2A-B56 dephosphorylates centromeric cohesin\"", "Reactome:R-HSA-199425 \"PHLPP dephosphorylates S473 in AKT\"", "Reactome:R-HSA-199959 \"ERKs are inactivated by protein phosphatase 2A\"", "Reactome:R-HSA-201787 \"PPP3 complex dephosphorylates DARPP-32 on Thr34\"", "Reactome:R-HSA-201790 \"DARPP-32 is dephosphorylated on Thr75 by PP2A\"", "Reactome:R-HSA-209055 \"PPM1A dephosphorylates nuclear SMAD2/3\"", "Reactome:R-HSA-2187401 \"MTMR4 dephosphorylates SMAD2/3\"", "Reactome:R-HSA-2995388 \"PP2A dephosphorylates BANF1\"", "Reactome:R-HSA-3002811 \"Myosin phosphatase dephosphorylates PLK1\"", "Reactome:R-HSA-3601585 \"PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex\"", "Reactome:R-HSA-380949 \"AMPK is dephosphorylated\"", "Reactome:R-HSA-4088141 \"PP2A-PPP2R2A dephosphorylates FOXM1\"", "Reactome:R-HSA-429730 \"PPM1L dephosphorylates multiphospho-CERT1-2\"", "Reactome:R-HSA-4419948 \"CTDNEP1:CNEP1R1 dephosphorylates LPIN\"", "Reactome:R-HSA-5672957 \"PP2A dephosphorylates KSR1\"", "Reactome:R-HSA-5672961 \"PP2A dephosphorylates inactive RAFs\"", "Reactome:R-HSA-5675431 \"PP2A dephosphorylates RAF1\"", "Reactome:R-HSA-5675433 \"PP5 dephosphorylates RAF1 S338\"", "Reactome:R-HSA-5679206 \"MTMR14, MTMR3 dephosphorylate PI3P\"", "Reactome:R-HSA-5683405 \"PPP5C dephosphorylates TP53BP1\"", "Reactome:R-HSA-5687758 \"PPP4C:PPP4R2 dephosphorylates RPA2\"", "Reactome:R-HSA-5692754 \"CDC14A,B dephosphorylate p-3S,T MAPK6\"", "Reactome:R-HSA-5694421 \"PP6 dephosphorylates SEC24\"", "Reactome:R-HSA-6792863 \"PP2A-PP2R5C dephosphorylates MDM2\"", "Reactome:R-HSA-6811504 \"AKT1 dephosphorylation by PP2A-B56-beta,gamma\"", "Reactome:R-HSA-74948 \"PP2A dephosphorylates p-RHO to RHO\"", "Reactome:R-HSA-8948139 \"p-S13-FUNDC1 is dephosphorylated by PGAM5\"", "Reactome:R-HSA-9619430 \"PPM1E dephosphorylates CAMK4\"", "Reactome:R-HSA-9619449 \"PPM1F dephosphorylates p-T286-CaMKII\"", "Reactome:R-HSA-9619467 \"PPM1F dephosphorylates CAMK1\"", "Reactome:R-HSA-9658445 \"MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs\"", "Reactome:R-HSA-9660536 \"SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex\"", "Reactome:R-HSA-9660538 \"Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs\"", "Reactome:R-HSA-9686524 \"PP6-PPP6R3 dephosphorylates TERF2\"", "Reactome:R-HSA-9831948 \"P:PP1 dephosphorylates M2-1\"", "Reactome:R-HSA-9853385 \"PPP1CC dephosphorylates PLK1\"", "Reactome:R-HSA-9861725 \"PGAM5 dodecamer dephosphorylates p-S336-ME1\"", "Reactome:R-HSA-9865226 \"PP2A dephosphorylates serine-127 of YAP1\"", "Reactome:R-HSA-9865238 \"PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin\"", "Reactome:R-HSA-9912527 \"H139Hfs13* PPM1K does not dephosphorylate BCKDH\"", "Reactome:R-HSA-9970190 \"PP1 dephosphorylates RNA Pol II\"", "RHEA:20629", "RHEA:47004" ] } } }, { "id": "GO:0004731", "name": "purine-nucleoside phosphorylase activity", "changes": { "xrefs": { "current": [ "EC:2.4.2.1", "MetaCyc:PNP-RXN", "Reactome:R-HSA-112033 \"PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine\"", "Reactome:R-HSA-112034 \"PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine\"", "Reactome:R-HSA-74242 \"PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose\"", "Reactome:R-HSA-74249 \"PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose\"", "Reactome:R-HSA-9735775 \"Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose\"", "Reactome:R-HSA-9735789 \"Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose\"", "Reactome:R-HSA-9755044 \"PNP trimer transforms RBV to T-CONH2\"", "RHEA:19805", "RHEA:27638", "RHEA:27642", "RHEA:27646" ], "previous": [ "EC:2.4.2.1", "MetaCyc:PNP-RXN", "Reactome:R-HSA-112033 \"PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine\"", "Reactome:R-HSA-112034 \"PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine\"", "Reactome:R-HSA-74242 \"PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose\"", "Reactome:R-HSA-74249 \"PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose\"", "Reactome:R-HSA-9735775 \"Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose\"", "Reactome:R-HSA-9735789 \"Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose\"", "Reactome:R-HSA-9755044 \"PNP trimer transforms RBV to T-CONH2\"", "RHEA:19805", "RHEA:27638", "RHEA:27642", "RHEA:27646" ] } } }, { "id": "GO:0004767", "name": "sphingomyelin phosphodiesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.4.12", "KEGG_REACTION:R02541", "MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN", "Reactome:R-HSA-1605797 \"SMPD1 hydrolyzes SPHM\"", "Reactome:R-HSA-1606273 \"SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)\"", "Reactome:R-HSA-1606288 \"SMPD4 hydrolyzes sphingomyelin (ER membrane)\"", "Reactome:R-HSA-1640164 \"ENPP7 hydrolyzes sphingomyelin\"", "Reactome:R-HSA-193706 \"Production of ceramide which can activate JNK and other targets\"", "Reactome:R-HSA-9769742 \"SMPD1 converts sphingomyelin to ceramide\"", "RHEA:19253", "RHEA:45324", "RHEA:54284" ], "previous": [ "EC:3.1.4.12", "KEGG_REACTION:R02541", "MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN", "Reactome:R-HSA-1605797 \"SMPD1 hydrolyzes SPHM\"", "Reactome:R-HSA-1606273 \"SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)\"", "Reactome:R-HSA-1606288 \"SMPD4 hydrolyzes sphingomyelin (ER membrane)\"", "Reactome:R-HSA-1640164 \"ENPP7 hydrolyzes sphingomyelin\"", "Reactome:R-HSA-193706 \"Production of ceramide which can activate JNK and other targets\"", "RHEA:19253", "RHEA:45324", "RHEA:54284" ] } } }, { "id": "GO:0004771", "name": "sterol ester esterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.13", "MetaCyc:STEROL-ESTERASE-RXN", "Reactome:R-HSA-192417 \"Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-6813720 \"NCEH1 hydrolyzes cholesterol esters\"", "Reactome:R-HSA-8865667 \"LIPA hydrolyses sterol esters to sterols and fatty acids\"", "RHEA:10100", "RHEA:33543", "RHEA:33547", "RHEA:33875", "RHEA:36403" ], "previous": [ "EC:3.1.1.13", "MetaCyc:STEROL-ESTERASE-RXN", "Reactome:R-HSA-192417 \"Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-6813720 \"NCEH1 hydrolyzes cholesterol esters\"", "Reactome:R-HSA-8865667 \"LIPA hydrolyses sterol esters to sterols and fatty acids\"", "RHEA:10100", "RHEA:33543", "RHEA:33547", "RHEA:36403" ] } } }, { "id": "GO:0004791", "name": "thioredoxin-disulfide reductase (NADPH) activity", "changes": { "xrefs": { "current": [ "EC:1.8.1.9", "KEGG_REACTION:R02016", "MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN", "Reactome:R-HSA-1222485 \"TrxB reactivates TrxA\"", "Reactome:R-HSA-3323050 \"TXNRD2 catalyzes the reduction of TXN2 by NADPH\"", "Reactome:R-HSA-73646 \"Regeneration of active (reduced) Thioredoxin\"", "Reactome:R-HSA-9617735 \"TXN disrupts FOXO4 complex with EP300\"", "RHEA:20345" ], "previous": [ "EC:1.8.1.9", "KEGG_REACTION:R02016", "MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN", "Reactome:R-HSA-1222485 \"TrxB reactivates TrxA\"", "Reactome:R-HSA-3323050 \"TXNRD2 catalyzes the reduction of TXN2 by NADPH\"", "Reactome:R-HSA-73646 \"thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+\"", "Reactome:R-HSA-9617735 \"TXN disrupts FOXO4 complex with EP300\"", "RHEA:20345" ] } } }, { "id": "GO:0004799", "name": "thymidylate synthase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.45", "KEGG_REACTION:R02101", "MetaCyc:THYMIDYLATESYN-RXN", "Reactome:R-HSA-73605 \"conversion of dUMP to dTMP\"", "RHEA:12104" ], "previous": [ "EC:2.1.1.45", "KEGG_REACTION:R02101", "MetaCyc:THYMIDYLATESYN-RXN", "Reactome:R-HSA-73605 \"dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate\"", "RHEA:12104" ] } } }, { "id": "GO:0004806", "name": "triacylglycerol lipase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.3", "MetaCyc:RXN-19278", "Reactome:R-HSA-1482777 \"TAG is hydrolyzed to DAG by PNPLA2/3\"", "Reactome:R-HSA-163551 \"triacylglycerol + H2O -> diacylglycerol + fatty acid\"", "Reactome:R-HSA-5694109 \"LIPC dimer hydrolyses TAG to DAG and FA\"", "Reactome:R-HSA-8848338 \"PNPLA4 hydrolyzes TAG\"", "Reactome:R-HSA-8848339 \"PNPLA5 hydrolyzes TAG\"", "RHEA:12044", "RHEA:33271", "RHEA:35667", "RHEA:38379", "RHEA:38387", "RHEA:38391", "RHEA:38395", "RHEA:38399", "RHEA:38403", "RHEA:38407", "RHEA:38411", "RHEA:38415", "RHEA:38419", "RHEA:38423", "RHEA:38427", "RHEA:38431", "RHEA:38495", "RHEA:38499", "RHEA:38575", "RHEA:39931", "RHEA:40047", "RHEA:40055", "RHEA:40475", "RHEA:40627", "RHEA:43732", "RHEA:44864", "RHEA:47864", "RHEA:48024", "RHEA:48028", "RHEA:59020", "RHEA:59024", "RHEA:63432", "RHEA:63436" ], "previous": [ "EC:3.1.1.3", "MetaCyc:RXN-19278", "Reactome:R-HSA-1482777 \"TAG is hydrolyzed to DAG by PNPLA2/3\"", "Reactome:R-HSA-163551 \"triacylglycerol + H2O -> diacylglycerol + fatty acid\"", "Reactome:R-HSA-5694109 \"LIPC dimer hydrolyses TAG to DAG and FA\"", "Reactome:R-HSA-8848338 \"PNPLA4 hydrolyzes TAG\"", "Reactome:R-HSA-8848339 \"PNPLA5 hydrolyzes TAG\"", "RHEA:12044", "RHEA:35667", "RHEA:38495", "RHEA:38575", "RHEA:40475", "RHEA:47864", "RHEA:48024", "RHEA:48028", "RHEA:59020", "RHEA:59024" ] } } }, { "id": "GO:0004842", "name": "ubiquitin-protein transferase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R03876", "Reactome:R-HSA-1234163 \"Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha\"", "Reactome:R-HSA-1234172 \"Nuclear VBC complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-1253282 \"ERBB4 ubiquitination by WWP1/ITCH\"", "Reactome:R-HSA-1358789 \"Self-ubiquitination of RNF41\"", "Reactome:R-HSA-1358790 \"RNF41 ubiquitinates ERBB3\"", "Reactome:R-HSA-1358792 \"RNF41 ubiquitinates activated ERBB3\"", "Reactome:R-HSA-1363331 \"Ubiquitination of p130 (RBL2) by SCF (Skp2)\"", "Reactome:R-HSA-168915 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-173542 \"SMURF2 ubiquitinates SMAD2\"", "Reactome:R-HSA-173545 \"Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling\"", "Reactome:R-HSA-174057 \"Multiubiquitination of APC/C-associated Cdh1\"", "Reactome:R-HSA-174104 \"Ubiquitination of Cyclin A by APC/C:Cdc20 complex\"", "Reactome:R-HSA-174144 \"Ubiquitination of Securin by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-174159 \"Ubiquitination of Emi1 by SCF-beta-TrCP\"", "Reactome:R-HSA-174195 \"Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex\"", "Reactome:R-HSA-174227 \"Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-179417 \"Multiubiquitination of Nek2A\"", "Reactome:R-HSA-180540 \"Multi-ubiquitination of APOBEC3G\"", "Reactome:R-HSA-180597 \"Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex\"", "Reactome:R-HSA-182986 \"CBL-mediated ubiquitination of CIN85\"", "Reactome:R-HSA-182993 \"Ubiquitination of stimulated EGFR (CBL)\"", "Reactome:R-HSA-183051 \"CBL ubiquitinates Sprouty\"", "Reactome:R-HSA-183084 \"CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix\"", "Reactome:R-HSA-183089 \"CBL binds and ubiquitinates phosphorylated Sprouty\"", "Reactome:R-HSA-1852623 \"Ubiquitination of NICD1 by FBWX7\"", "Reactome:R-HSA-187575 \"Ubiquitination of phospho-p27/p21\"", "Reactome:R-HSA-1912357 \"ITCH ubiquitinates DTX\"", "Reactome:R-HSA-1912386 \"Ubiquitination of NOTCH1 by ITCH in the absence of ligand\"", "Reactome:R-HSA-1918092 \"CHIP (STUB1) mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1918095 \"CUL5 mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1977296 \"NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer\"", "Reactome:R-HSA-1980074 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1\"", "Reactome:R-HSA-1980118 \"ARRB mediates NOTCH1 ubiquitination\"", "Reactome:R-HSA-201425 \"Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling\"", "Reactome:R-HSA-202453 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-202534 \"Ubiquitination of NEMO by TRAF6\"", "Reactome:R-HSA-205118 \"TRAF6 polyubiquitinates NRIF\"", "Reactome:R-HSA-209063 \"Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex\"", "Reactome:R-HSA-211734 \"Ubiquitination of PAK-2p34\"", "Reactome:R-HSA-2169050 \"SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7\"", "Reactome:R-HSA-2172172 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH2\"", "Reactome:R-HSA-2179276 \"SMURF2 monoubiquitinates SMAD3\"", "Reactome:R-HSA-2186747 \"Ubiquitination of SKI/SKIL by RNF111/SMURF2\"", "Reactome:R-HSA-2186785 \"RNF111 ubiquitinates SMAD7\"", "Reactome:R-HSA-2187368 \"STUB1 (CHIP) ubiquitinates SMAD3\"", "Reactome:R-HSA-2213017 \"Auto-ubiquitination of TRAF3\"", "Reactome:R-HSA-264444 \"Autoubiquitination of phospho-COP1(Ser-387 )\"", "Reactome:R-HSA-2682349 \"RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels\"", "Reactome:R-HSA-2730904 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-2737728 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants\"", "Reactome:R-HSA-2769007 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants\"", "Reactome:R-HSA-2900765 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants\"", "Reactome:R-HSA-3000335 \"SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA\"", "Reactome:R-HSA-3134804 \"STING ubiquitination by TRIM32 or TRIM56\"", "Reactome:R-HSA-3134946 \"DDX41 ubiquitination by TRIM21\"", "Reactome:R-HSA-3249386 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1\"", "Reactome:R-HSA-3780995 \"NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2\"", "Reactome:R-HSA-3781009 \"NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1\"", "Reactome:R-HSA-3788724 \"Cdh1:APC/C ubiquitinates EHMT1 and EHMT2\"", "Reactome:R-HSA-3797226 \"Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)\"", "Reactome:R-HSA-4332236 \"CBL neddylates TGFBR2\"", "Reactome:R-HSA-446877 \"TRAF6 is K63 poly-ubiquitinated\"", "Reactome:R-HSA-450358 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation\"", "Reactome:R-HSA-451418 \"Pellino ubiquitinates IRAK1\"", "Reactome:R-HSA-5357757 \"BIRC(cIAP1/2) ubiquitinates RIPK1\"", "Reactome:R-HSA-5362412 \"SYVN1 ubiquitinates Hh C-terminal fragments\"", "Reactome:R-HSA-5483238 \"Hh processing variants are ubiquitinated\"", "Reactome:R-HSA-5607725 \"SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP\"", "Reactome:R-HSA-5607728 \"beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex\"", "Reactome:R-HSA-5607756 \"TRAF6 oligomer autoubiquitinates\"", "Reactome:R-HSA-5607757 \"K63polyUb-TRAF6 ubiquitinates TAK1\"", "Reactome:R-HSA-5610742 \"SCF(beta-TrCP) ubiquitinates p-GLI1\"", "Reactome:R-HSA-5610745 \"SCF(beta-TrCP) ubiquitinates p-GLI2\"", "Reactome:R-HSA-5610746 \"SCF(beta-TrCP) ubiquitinates p-GLI3\"", "Reactome:R-HSA-5652009 \"RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA\"", "Reactome:R-HSA-5655170 \"RCHY1 monoubiquitinates POLH\"", "Reactome:R-HSA-5660753 \"SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA\"", "Reactome:R-HSA-5667107 \"SIAH1, SIAH2 ubiquitinate SNCAIP\"", "Reactome:R-HSA-5667111 \"PARK2 K63-Ubiquitinates SNCAIP\"", "Reactome:R-HSA-5668454 \"K63polyUb-cIAP1,2 ubiquitinates TRAF3\"", "Reactome:R-HSA-5668534 \"cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK\"", "Reactome:R-HSA-5675470 \"BIRC2/3 (cIAP1/2) is autoubiquitinated\"", "Reactome:R-HSA-5684250 \"SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2\"", "Reactome:R-HSA-5691108 \"SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2\"", "Reactome:R-HSA-5693108 \"TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains\"", "Reactome:R-HSA-68712 \"The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1\"", "Reactome:R-HSA-69598 \"Ubiquitination of phosphorylated CDC25A\"", "Reactome:R-HSA-741386 \"RIP2 induces K63-linked ubiquitination of NEMO\"", "Reactome:R-HSA-75824 \"Ubiquitination of Cyclin D1\"", "Reactome:R-HSA-870449 \"TRIM33 monoubiquitinates SMAD4\"", "Reactome:R-HSA-8948709 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3\"", "Reactome:R-HSA-8956106 \"VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-9013069 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH3\"", "Reactome:R-HSA-9013974 \"Auto-ubiquitination of TRAF3 within activated TLR3 complex\"", "Reactome:R-HSA-9014342 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-918224 \"DDX58 is K63 polyubiquitinated\"", "Reactome:R-HSA-936412 \"RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS\"", "Reactome:R-HSA-936942 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2\"", "Reactome:R-HSA-936986 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains\"", "Reactome:R-HSA-9628444 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation\"", "Reactome:R-HSA-9645394 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation\"", "Reactome:R-HSA-9645414 \"Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer\"", "Reactome:R-HSA-9688831 \"STUB1 ubiquitinates RIPK3 at K55, K363\"", "Reactome:R-HSA-9701000 \"BRCA1:BARD1 heterodimer autoubiquitinates\"", "Reactome:R-HSA-9750946 \"TRAF2,6 ubiquitinates NLRC5\"", "Reactome:R-HSA-975118 \"TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex\"", "Reactome:R-HSA-975147 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane\"", "Reactome:R-HSA-9758604 \"Ubiquitination of IKBKG by TRAF6\"", "Reactome:R-HSA-9766227 \"MDM2 mediates CDH1 ubiquitination\"", "Reactome:R-HSA-9793444 \"ITCH polyubiquitinates MLKL at K50\"", "Reactome:R-HSA-9793485 \"PRKN polyubiquitinates RIPK3\"", "Reactome:R-HSA-9793679 \"LUBAC ubiquitinates RIPK1 at K627\"", "Reactome:R-HSA-9796346 \"MIB2 ubiquitinates RIPK1 at K377, K604, K634\"", "Reactome:R-HSA-9796387 \"STUB1 ubiquitinates RIPK1 at K571, K604, K627\"", "Reactome:R-HSA-9796626 \"MIB2 ubiquitinates CFLAR\"", "Reactome:R-HSA-9815507 \"MIB2 ubiquitinates CYLD at K338, K530\"", "Reactome:R-HSA-9817362 \"SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex\"", "Reactome:R-HSA-983140 \"Transfer of Ub from E2 to substrate and release of E2\"", "Reactome:R-HSA-983153 \"E1 mediated ubiquitin activation\"", "Reactome:R-HSA-983156 \"Polyubiquitination of substrate\"", "Reactome:R-HSA-9833155 \"Ubiquitination of STAT2\"", "Reactome:R-HSA-9834070 \"PRKN ubiquitinates MOM substrates\"", "Reactome:R-HSA-9861563 \"CTLH E3 ligase ubiquitinates LDHA\"", "Reactome:R-HSA-9861640 \"CTLH E3 ligase ubiquitinates PKM-1\"", "Reactome:R-HSA-9929350 \"Ubiquitination of CD274 by BTRC-SCF E3-ligase complex\"", "Reactome:R-HSA-9934753 \"CBLL1 ubiquitinates CDH1\"", "Reactome:R-HSA-9948301 \"ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit\"", "Reactome:R-HSA-9954721 \"NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide\"", "Reactome:R-HSA-9955146 \"S.flexneri ipaH9.8 ubiquitinates GBPs\"", "Reactome:R-HSA-9958873 \"Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination\"", "Reactome:R-HSA-9970191 \"RBBP6 activates CPSF complex\"" ], "previous": [ "KEGG_REACTION:R03876", "Reactome:R-HSA-1234163 \"Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha\"", "Reactome:R-HSA-1234172 \"Nuclear VBC complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-1253282 \"ERBB4 ubiquitination by WWP1/ITCH\"", "Reactome:R-HSA-1358789 \"Self-ubiquitination of RNF41\"", "Reactome:R-HSA-1358790 \"RNF41 ubiquitinates ERBB3\"", "Reactome:R-HSA-1358792 \"RNF41 ubiquitinates activated ERBB3\"", "Reactome:R-HSA-1363331 \"Ubiquitination of p130 (RBL2) by SCF (Skp2)\"", "Reactome:R-HSA-168915 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-173542 \"SMURF2 ubiquitinates SMAD2\"", "Reactome:R-HSA-173545 \"Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling\"", "Reactome:R-HSA-174057 \"Multiubiquitination of APC/C-associated Cdh1\"", "Reactome:R-HSA-174104 \"Ubiquitination of Cyclin A by APC/C:Cdc20 complex\"", "Reactome:R-HSA-174144 \"Ubiquitination of Securin by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-174159 \"Ubiquitination of Emi1 by SCF-beta-TrCP\"", "Reactome:R-HSA-174195 \"Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex\"", "Reactome:R-HSA-174227 \"Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex\"", "Reactome:R-HSA-179417 \"Multiubiquitination of Nek2A\"", "Reactome:R-HSA-180540 \"Multi-ubiquitination of APOBEC3G\"", "Reactome:R-HSA-180597 \"Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex\"", "Reactome:R-HSA-182986 \"CBL-mediated ubiquitination of CIN85\"", "Reactome:R-HSA-182993 \"Ubiquitination of stimulated EGFR (CBL)\"", "Reactome:R-HSA-183051 \"CBL ubiquitinates Sprouty\"", "Reactome:R-HSA-183084 \"CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix\"", "Reactome:R-HSA-183089 \"CBL binds and ubiquitinates phosphorylated Sprouty\"", "Reactome:R-HSA-1852623 \"Ubiquitination of NICD1 by FBWX7\"", "Reactome:R-HSA-187575 \"Ubiquitination of phospho-p27/p21\"", "Reactome:R-HSA-1912357 \"ITCH ubiquitinates DTX\"", "Reactome:R-HSA-1912386 \"Ubiquitination of NOTCH1 by ITCH in the absence of ligand\"", "Reactome:R-HSA-1918092 \"CHIP (STUB1) mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1918095 \"CUL5 mediates ubiquitination of ERBB2\"", "Reactome:R-HSA-1977296 \"NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer\"", "Reactome:R-HSA-1980074 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1\"", "Reactome:R-HSA-1980118 \"ARRB mediates NOTCH1 ubiquitination\"", "Reactome:R-HSA-201425 \"Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling\"", "Reactome:R-HSA-202453 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-202534 \"Ubiquitination of NEMO by TRAF6\"", "Reactome:R-HSA-205118 \"TRAF6 polyubiquitinates NRIF\"", "Reactome:R-HSA-209063 \"Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex\"", "Reactome:R-HSA-211734 \"Ubiquitination of PAK-2p34\"", "Reactome:R-HSA-2169050 \"SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7\"", "Reactome:R-HSA-2172172 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH2\"", "Reactome:R-HSA-2179276 \"SMURF2 monoubiquitinates SMAD3\"", "Reactome:R-HSA-2186747 \"Ubiquitination of SKI/SKIL by RNF111/SMURF2\"", "Reactome:R-HSA-2186785 \"RNF111 ubiquitinates SMAD7\"", "Reactome:R-HSA-2187368 \"STUB1 (CHIP) ubiquitinates SMAD3\"", "Reactome:R-HSA-2213017 \"Auto-ubiquitination of TRAF3\"", "Reactome:R-HSA-264444 \"Autoubiquitination of phospho-COP1(Ser-387 )\"", "Reactome:R-HSA-2682349 \"RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels\"", "Reactome:R-HSA-2730904 \"Auto-ubiquitination of TRAF6\"", "Reactome:R-HSA-2737728 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants\"", "Reactome:R-HSA-2769007 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants\"", "Reactome:R-HSA-2900765 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants\"", "Reactome:R-HSA-3000335 \"SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA\"", "Reactome:R-HSA-3134804 \"STING ubiquitination by TRIM32 or TRIM56\"", "Reactome:R-HSA-3134946 \"DDX41 ubiquitination by TRIM21\"", "Reactome:R-HSA-3249386 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1\"", "Reactome:R-HSA-3780995 \"NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2\"", "Reactome:R-HSA-3781009 \"NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1\"", "Reactome:R-HSA-3788724 \"Cdh1:APC/C ubiquitinates EHMT1 and EHMT2\"", "Reactome:R-HSA-3797226 \"Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)\"", "Reactome:R-HSA-4332236 \"CBL neddylates TGFBR2\"", "Reactome:R-HSA-446877 \"TRAF6 is K63 poly-ubiquitinated\"", "Reactome:R-HSA-450358 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation\"", "Reactome:R-HSA-451418 \"Pellino ubiquitinates IRAK1\"", "Reactome:R-HSA-5357757 \"BIRC(cIAP1/2) ubiquitinates RIPK1\"", "Reactome:R-HSA-5362412 \"SYVN1 ubiquitinates Hh C-terminal fragments\"", "Reactome:R-HSA-5483238 \"Hh processing variants are ubiquitinated\"", "Reactome:R-HSA-5607725 \"SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP\"", "Reactome:R-HSA-5607728 \"beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex\"", "Reactome:R-HSA-5607756 \"TRAF6 oligomer autoubiquitinates\"", "Reactome:R-HSA-5607757 \"K63polyUb-TRAF6 ubiquitinates TAK1\"", "Reactome:R-HSA-5610742 \"SCF(beta-TrCP) ubiquitinates p-GLI1\"", "Reactome:R-HSA-5610745 \"SCF(beta-TrCP) ubiquitinates p-GLI2\"", "Reactome:R-HSA-5610746 \"SCF(beta-TrCP) ubiquitinates p-GLI3\"", "Reactome:R-HSA-5652009 \"RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA\"", "Reactome:R-HSA-5655170 \"RCHY1 monoubiquitinates POLH\"", "Reactome:R-HSA-5660753 \"SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA\"", "Reactome:R-HSA-5667107 \"SIAH1, SIAH2 ubiquitinate SNCAIP\"", "Reactome:R-HSA-5667111 \"PARK2 K63-Ubiquitinates SNCAIP\"", "Reactome:R-HSA-5668454 \"K63polyUb-cIAP1,2 ubiquitinates TRAF3\"", "Reactome:R-HSA-5668534 \"cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK\"", "Reactome:R-HSA-5675470 \"BIRC2/3 (cIAP1/2) is autoubiquitinated\"", "Reactome:R-HSA-5684250 \"SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2\"", "Reactome:R-HSA-5691108 \"SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2\"", "Reactome:R-HSA-5693108 \"TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains\"", "Reactome:R-HSA-68712 \"The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1\"", "Reactome:R-HSA-69598 \"Ubiquitination of phosphorylated CDC25A\"", "Reactome:R-HSA-741386 \"RIP2 induces K63-linked ubiquitination of NEMO\"", "Reactome:R-HSA-75824 \"Ubiquitination of Cyclin D1\"", "Reactome:R-HSA-870449 \"TRIM33 monoubiquitinates SMAD4\"", "Reactome:R-HSA-8948709 \"DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3\"", "Reactome:R-HSA-8956106 \"VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha\"", "Reactome:R-HSA-9013069 \"Ubiquitination of DLL/JAG ligands upon binding to NOTCH3\"", "Reactome:R-HSA-9013974 \"Auto-ubiquitination of TRAF3 within activated TLR3 complex\"", "Reactome:R-HSA-9014342 \"K63-linked ubiquitination of RIP1 bound to the activated TLR complex\"", "Reactome:R-HSA-918224 \"DDX58 is K63 polyubiquitinated\"", "Reactome:R-HSA-936412 \"RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS\"", "Reactome:R-HSA-936942 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2\"", "Reactome:R-HSA-936986 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains\"", "Reactome:R-HSA-9628444 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation\"", "Reactome:R-HSA-9645394 \"Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation\"", "Reactome:R-HSA-9645414 \"Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer\"", "Reactome:R-HSA-9688831 \"STUB1 ubiquitinates RIPK3 at K55, K363\"", "Reactome:R-HSA-9701000 \"BRCA1:BARD1 heterodimer autoubiquitinates\"", "Reactome:R-HSA-9750946 \"TRAF2,6 ubiquitinates NLRC5\"", "Reactome:R-HSA-975118 \"TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex\"", "Reactome:R-HSA-975147 \"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane\"", "Reactome:R-HSA-9758604 \"Ubiquitination of IKBKG by TRAF6\"", "Reactome:R-HSA-9766227 \"MDM2 mediates CDH1 ubiquitination\"", "Reactome:R-HSA-9793444 \"ITCH polyubiquitinates MLKL at K50\"", "Reactome:R-HSA-9793485 \"PRKN polyubiquitinates RIPK3\"", "Reactome:R-HSA-9793679 \"LUBAC ubiquitinates RIPK1 at K627\"", "Reactome:R-HSA-9796346 \"MIB2 ubiquitinates RIPK1 at K377, K604, K634\"", "Reactome:R-HSA-9796387 \"STUB1 ubiquitinates RIPK1 at K571, K604, K627\"", "Reactome:R-HSA-9796626 \"MIB2 ubiquitinates CFLAR\"", "Reactome:R-HSA-9815507 \"MIB2 ubiquitinates CYLD at K338, K530\"", "Reactome:R-HSA-9817362 \"SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex\"", "Reactome:R-HSA-983140 \"Transfer of Ub from E2 to substrate and release of E2\"", "Reactome:R-HSA-983153 \"E1 mediated ubiquitin activation\"", "Reactome:R-HSA-983156 \"Polyubiquitination of substrate\"", "Reactome:R-HSA-9833155 \"Ubiquitination of STAT2\"", "Reactome:R-HSA-9834070 \"PRKN ubiquitinates MOM substrates\"", "Reactome:R-HSA-9861563 \"CTLH E3 ligase ubiquitinates LDHA\"", "Reactome:R-HSA-9861640 \"CTLH E3 ligase ubiquitinates PKM-1\"", "Reactome:R-HSA-9929350 \"Ubiquitination of CD274 by BTRC-SCF E3-ligase complex\"", "Reactome:R-HSA-9934753 \"CBLL1 ubiquitinates CDH1\"", "Reactome:R-HSA-9948301 \"ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit\"", "Reactome:R-HSA-9954721 \"NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide\"", "Reactome:R-HSA-9955146 \"S.flexneri ipaH9.8 ubiquitinates GBPs\"", "Reactome:R-HSA-9970191 \"RBBP6 activates CPSF complex\"" ] } } }, { "id": "GO:0004855", "name": "xanthine oxidase activity", "changes": { "xrefs": { "current": [ "MetaCyc:XANTHINE-OXIDASE-RXN", "Reactome:R-HSA-74258 \"XDH oxidizes xanthine to form urate\"", "Reactome:R-HSA-9748991 \"XDH oxidises 6MP to 6TU\"", "RHEA:21132" ], "previous": [ "EC:1.17.3.2", "MetaCyc:XANTHINE-OXIDASE-RXN", "Reactome:R-HSA-74258 \"XDH oxidizes xanthine to form urate\"", "Reactome:R-HSA-9748991 \"XDH oxidises 6MP to 6TU\"", "RHEA:21132" ] } } }, { "id": "GO:0004867", "name": "serine-type endopeptidase inhibitor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-158795 \"fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1\"", "Reactome:R-HSA-158800 \"fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1\"", "Reactome:R-HSA-158893 \"alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin\"", "Reactome:R-HSA-159001 \"urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-159005 \"urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-9823284 \"FXa binds SERPINC1:HS\"" ], "previous": [ "Reactome:R-HSA-158795 \"fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1\"", "Reactome:R-HSA-158800 \"fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1\"", "Reactome:R-HSA-158893 \"alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin\"", "Reactome:R-HSA-159001 \"urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR\"", "Reactome:R-HSA-159005 \"urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR\"" ] } } }, { "id": "GO:0005085", "name": "guanyl-nucleotide exchange factor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-109807 \"GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-109817 \"GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-114544 \"p115-RhoGEF activation of RHOA\"", "Reactome:R-HSA-1168636 \"p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP\"", "Reactome:R-HSA-1225951 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)\"", "Reactome:R-HSA-1225957 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)\"", "Reactome:R-HSA-1250383 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4\"", "Reactome:R-HSA-1250463 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers\"", "Reactome:R-HSA-1250498 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers\"", "Reactome:R-HSA-1306972 \"RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers\"", "Reactome:R-HSA-1433415 \"Activation of RAC1\"", "Reactome:R-HSA-1433471 \"Activation of RAS by p-KIT bound SOS1\"", "Reactome:R-HSA-156913 \"Regeneration of eEF1A:GTP by eEF1B activity\"", "Reactome:R-HSA-169904 \"C3G stimulates nucleotide exchange on Rap1\"", "Reactome:R-HSA-170979 \"(Frs2)C3G stimulates nucleotide exchange on Rap1\"", "Reactome:R-HSA-171026 \"Guanine nucleotide exchange on RAL\"", "Reactome:R-HSA-177938 \"SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)\"", "Reactome:R-HSA-177945 \"SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)\"", "Reactome:R-HSA-180687 \"Conversion of Ran-GDP to Ran-GTP\"", "Reactome:R-HSA-186834 \"SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)\"", "Reactome:R-HSA-187746 \"RIT/RIN are activated\"", "Reactome:R-HSA-194518 \"RhoA is activated by nucleotide exchange and inhibits axonal growth\"", "Reactome:R-HSA-2029445 \"An unknown GEF exchanges GTP for GDP on CDC42:GDP\"", "Reactome:R-HSA-2029451 \"Activation of RAC1 by VAV\"", "Reactome:R-HSA-2029467 \"Activation of RAC1 by CRKII:DOCK180:ELMO\"", "Reactome:R-HSA-203977 \"SAR1 Activation And Membrane Binding\"", "Reactome:R-HSA-205039 \"p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor\"", "Reactome:R-HSA-210977 \"Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)\"", "Reactome:R-HSA-2179407 \"SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)\"", "Reactome:R-HSA-2424476 \"Activation of RAC1 by VAV2/3\"", "Reactome:R-HSA-2424477 \"SOS mediated nucleotide exchange of RAS (SHC)\"", "Reactome:R-HSA-2485180 \"MII catalyses GDP/GTP exchange on Gt\"", "Reactome:R-HSA-2730840 \"Activation of RAC1 by VAV\"", "Reactome:R-HSA-350769 \"trans-Golgi Network Coat Activation\"", "Reactome:R-HSA-354173 \"Activation of Rap1 by cytosolic GEFs\"", "Reactome:R-HSA-379044 \"Liganded Gs-activating GPCR acts as a GEF for Gs\"", "Reactome:R-HSA-379048 \"Liganded Gq/11-activating GPCRs act as GEFs for Gq/11\"", "Reactome:R-HSA-380073 \"Liganded Gi-activating GPCR acts as a GEF for Gi\"", "Reactome:R-HSA-381727 \"RAP1A exchanges GDP for GTP\"", "Reactome:R-HSA-389348 \"Activation of Rac1 by pVav1\"", "Reactome:R-HSA-389350 \"Activation of Cdc42 by pVav1\"", "Reactome:R-HSA-392054 \"NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras\"", "Reactome:R-HSA-392195 \"Gi activation by P2Y purinoceptor 12\"", "Reactome:R-HSA-3928592 \"p190RhoGEF exchanges GTP for GDP on RHOA, activating it\"", "Reactome:R-HSA-3928612 \"KALRN exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928628 \"VAV exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928632 \"ITSN1 exchanges GTP for GDP on CDC42, activating it\"", "Reactome:R-HSA-3928633 \"bPIX exchanges GTP for GDP on RAC, activating it\"", "Reactome:R-HSA-3928642 \"TIAM1 exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928651 \"NGEF exchanges GTP for GDP on RHOA\"", "Reactome:R-HSA-392870 \"Gs activation by prostacyclin receptor\"", "Reactome:R-HSA-3965444 \"WNT:FZD complex promotes G-protein nucleotide exchange\"", "Reactome:R-HSA-399938 \"Activation of Rac1 by FARP2\"", "Reactome:R-HSA-399995 \"Muscarinic Acetylcholine Receptor M3 activates Gq\"", "Reactome:R-HSA-400037 \"Gi,Go Heterotrimeric G-protein complex dissociates\"", "Reactome:R-HSA-400092 \"Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins\"", "Reactome:R-HSA-4093336 \"p-TIAM1 exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-416530 \"FFAR1:FFAR1 ligands activate Gq\"", "Reactome:R-HSA-416588 \"Activation of Rho by LARG and PDZ-RhoGEF\"", "Reactome:R-HSA-418579 \"Gq activation by P2Y purinoceptor 1\"", "Reactome:R-HSA-418850 \"Activation of Cdc42\"", "Reactome:R-HSA-418856 \"Activation of Rac1\"", "Reactome:R-HSA-419166 \"GEFs activate RhoA,B,C\"", "Reactome:R-HSA-420883 \"Opsins act as GEFs for G alpha-t\"", "Reactome:R-HSA-428535 \"Activation of RAC1 by SOS\"", "Reactome:R-HSA-428750 \"Gq activation by TP receptor\"", "Reactome:R-HSA-428917 \"G13 activation by TP receptor\"", "Reactome:R-HSA-442273 \"VAV1 is a GEF for Rho/Rac family GTPases\"", "Reactome:R-HSA-442291 \"VAV2 is a GEF for Rho/Rac family kinases\"", "Reactome:R-HSA-442314 \"VAV3 is a GEF for Rho/Rac family kinases\"", "Reactome:R-HSA-442732 \"NMDA-activated RASGRF1 activates RAS\"", "Reactome:R-HSA-445064 \"Activation of Rac1 by VAV2\"", "Reactome:R-HSA-5218829 \"VEGF induces CDC42 activation by unknown mechanism\"", "Reactome:R-HSA-5218839 \"DOCK180:ELMO exchanges GTP for GDP, activating RAC1\"", "Reactome:R-HSA-5218850 \"VAV exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-5617816 \"RAB3IP stimulates nucleotide exchange on RAB8A\"", "Reactome:R-HSA-5623508 \"GBF1 stimulates nucleotide exchange on ARF4\"", "Reactome:R-HSA-5623521 \"RAB3IP stimulates nucleotide exchange on RAB8A\"", "Reactome:R-HSA-5637806 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)\"", "Reactome:R-HSA-5637808 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)\"", "Reactome:R-HSA-5654392 \"Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654402 \"Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654413 \"Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654426 \"Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654600 \"Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654618 \"Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654647 \"Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654663 \"Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655241 \"Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655277 \"Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655326 \"Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655347 \"Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5672965 \"RAS GEFs promote RAS nucleotide exchange\"", "Reactome:R-HSA-5686071 \"GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-5686318 \"GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-5694409 \"Nucleotide exchange on RAB1\"", "Reactome:R-HSA-6807868 \"GBF1 stimulates ARF nucleotide exchange\"", "Reactome:R-HSA-6811414 \"GBF1 stimulates nucleotide exchange on ARF\"", "Reactome:R-HSA-6811418 \"ARFGAPs stimulate ARF GTPase activity at the Golgi membrane\"", "Reactome:R-HSA-6811429 \"RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange\"", "Reactome:R-HSA-749453 \"Liganded Gz-activating GPCR acts as a GEF for Gz\"", "Reactome:R-HSA-751029 \"Liganded G12/13-activating GPCR acts as a GEF for G12/13\"", "Reactome:R-HSA-825631 \"Glucagon:GCGR mediates GTP-GDP exchange\"", "Reactome:R-HSA-8848618 \"Activation of RAC1 by the PXN:CRK complex\"", "Reactome:R-HSA-8850041 \"RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18\"", "Reactome:R-HSA-8851827 \"RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1\"", "Reactome:R-HSA-8851877 \"RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET\"", "Reactome:R-HSA-8851899 \"RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET\"", "Reactome:R-HSA-8875318 \"RAB3 GEFs exchange GTP for GDP on RAB3A\"", "Reactome:R-HSA-8875320 \"RAB5 GEFs exchange GTP for GDP on RAB5\"", "Reactome:R-HSA-8875568 \"RAPGEF1 activates RAP1\"", "Reactome:R-HSA-8875591 \"DOCK7 activates RAC1\"", "Reactome:R-HSA-8876188 \"DENND4s exchange GTP for GDP on RAB10\"", "Reactome:R-HSA-8876190 \"RAB8 GEFs exchange GTP for GDP on RAB8\"", "Reactome:R-HSA-8876191 \"RAB9 GEFs exchange GTP for GDP on RAB9\"", "Reactome:R-HSA-8876193 \"RIC1-RGP1 exchanges GTP for GDP on RAB6\"", "Reactome:R-HSA-8876454 \"DENND3 exchanges GTP for GDP on RAB12\"", "Reactome:R-HSA-8876615 \"RAB13 GEFs exchange GTP for GDP on RAB13\"", "Reactome:R-HSA-8876616 \"DENND6A,B exchange GTP for GDP on RAB14\"", "Reactome:R-HSA-8876837 \"RAB21 GEFs exchange GTP for GDP on RAB21\"", "Reactome:R-HSA-8877308 \"MADD exchanges GTP for GDP on RAB27\"", "Reactome:R-HSA-8877311 \"RAB31 GEFs exchange GTP for GDP on RAB31\"", "Reactome:R-HSA-8877451 \"MON1:CCZ1 exchanges GTP for GDP on RAB7\"", "Reactome:R-HSA-8877475 \"TRAPPC complexes exchange GTP for GDP on RAB1\"", "Reactome:R-HSA-8877612 \"DENND1s exchange GTP for GDP on RAB35\"", "Reactome:R-HSA-8877760 \"HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38\"", "Reactome:R-HSA-8877813 \"DENND5A,B exchange GTP for GDP on RAB39\"", "Reactome:R-HSA-8877998 \"RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18\"", "Reactome:R-HSA-8964604 \"CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated\"", "Reactome:R-HSA-8980691 \"RHOA GEFs activate RHOA\"", "Reactome:R-HSA-8982637 \"Opsins binds G alpha-t\"", "Reactome:R-HSA-8982640 \"G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)\"", "Reactome:R-HSA-9013023 \"RHOB GEFs activate RHOB\"", "Reactome:R-HSA-9013109 \"RHOC GEFs activate RHOC\"", "Reactome:R-HSA-9013143 \"RAC1 GEFs activate RAC1\"", "Reactome:R-HSA-9013159 \"CDC42 GEFs activate CDC42\"", "Reactome:R-HSA-9013435 \"RHOD auto-activates\"", "Reactome:R-HSA-9014296 \"RAC2 GEFs activate RAC2\"", "Reactome:R-HSA-9014433 \"RHOG GEFs activate RHOG\"", "Reactome:R-HSA-9017491 \"RHOJ GEFs activate RHOJ\"", "Reactome:R-HSA-9018747 \"RHOQ GEFs activate RHOQ\"", "Reactome:R-HSA-9018768 \"RHOU auto-activates\"", "Reactome:R-HSA-9018804 \"RAC3 GEFs activate RAC3\"", "Reactome:R-HSA-9018817 \"RHOT1 GEFs activate RHOT1\"", "Reactome:R-HSA-9018825 \"RHOT2 GEFs activate RHOT2\"", "Reactome:R-HSA-9026891 \"NTRK2 activates RAS signaling through SHC1\"", "Reactome:R-HSA-9029158 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS\"", "Reactome:R-HSA-9032067 \"NTRK2 activates RAS signaling through FRS2\"", "Reactome:R-HSA-9032798 \"DOCK3 activates RAC1\"", "Reactome:R-HSA-9033292 \"NTRK2 and CDK5 promote activation of RAC1 by TIAM1\"", "Reactome:R-HSA-9036301 \"ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s\"", "Reactome:R-HSA-939265 \"Activation of Rap1 by membrane-associated GEFs\"", "Reactome:R-HSA-9607304 \"SOS1-mediated nucleotide exchange of RAS downstream of FLT3\"", "Reactome:R-HSA-9619803 \"p-S516-ARHGEF7 activates RAC1\"", "Reactome:R-HSA-9624845 \"RCC1 stimulates GDP to GTP exchange on RAN\"", "Reactome:R-HSA-9634418 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1\"", "Reactome:R-HSA-9639286 \"RRAGC,D exchanges GTP for GDP\"", "Reactome:R-HSA-9640167 \"RRAGA,B exchanges GDP for GTP\"", "Reactome:R-HSA-9660824 \"ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs\"", "Reactome:R-HSA-9664991 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants\"", "Reactome:R-HSA-9665009 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR\"", "Reactome:R-HSA-9665404 \"RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1\"", "Reactome:R-HSA-9665408 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2\"", "Reactome:R-HSA-9665700 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants\"", "Reactome:R-HSA-9665707 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR\"", "Reactome:R-HSA-9666428 \"DOCK180 exchanges GTP for GDP on RAC1:GDP\"", "Reactome:R-HSA-9666430 \"p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP\"", "Reactome:R-HSA-9670436 \"p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS\"", "Reactome:R-HSA-9672163 \"SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672170 \"SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors\"", "Reactome:R-HSA-9680385 \"CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS\"", "Reactome:R-HSA-9693111 \"RHOF auto-activates\"", "Reactome:R-HSA-9695853 \"FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS\"", "Reactome:R-HSA-9703441 \"SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants\"", "Reactome:R-HSA-9751201 \"p-VAV1,2,3 exchange 6TGTP for GDP on RAC1\"", "Reactome:R-HSA-9970163 \"SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)\"" ], "previous": [ "Reactome:R-HSA-109807 \"GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-109817 \"GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-114544 \"p115-RhoGEF activation of RHOA\"", "Reactome:R-HSA-1168636 \"p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP\"", "Reactome:R-HSA-1225951 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)\"", "Reactome:R-HSA-1225957 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)\"", "Reactome:R-HSA-1250383 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4\"", "Reactome:R-HSA-1250463 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers\"", "Reactome:R-HSA-1250498 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers\"", "Reactome:R-HSA-1306972 \"RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers\"", "Reactome:R-HSA-1433415 \"Activation of RAC1\"", "Reactome:R-HSA-1433471 \"Activation of RAS by p-KIT bound SOS1\"", "Reactome:R-HSA-156913 \"Regeneration of eEF1A:GTP by eEF1B activity\"", "Reactome:R-HSA-169904 \"C3G stimulates nucleotide exchange on Rap1\"", "Reactome:R-HSA-170979 \"(Frs2)C3G stimulates nucleotide exchange on Rap1\"", "Reactome:R-HSA-171026 \"Guanine nucleotide exchange on RAL\"", "Reactome:R-HSA-177938 \"SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)\"", "Reactome:R-HSA-177945 \"SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)\"", "Reactome:R-HSA-180687 \"Conversion of Ran-GDP to Ran-GTP\"", "Reactome:R-HSA-186834 \"SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)\"", "Reactome:R-HSA-187746 \"RIT/RIN are activated\"", "Reactome:R-HSA-194518 \"RhoA is activated by nucleotide exchange and inhibits axonal growth\"", "Reactome:R-HSA-2029445 \"An unknown GEF exchanges GTP for GDP on CDC42:GDP\"", "Reactome:R-HSA-2029451 \"Activation of RAC1 by VAV\"", "Reactome:R-HSA-2029467 \"Activation of RAC1 by CRKII:DOCK180:ELMO\"", "Reactome:R-HSA-203977 \"SAR1 Activation And Membrane Binding\"", "Reactome:R-HSA-205039 \"p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor\"", "Reactome:R-HSA-210977 \"Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)\"", "Reactome:R-HSA-2179407 \"SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)\"", "Reactome:R-HSA-2424476 \"Activation of RAC1 by VAV2/3\"", "Reactome:R-HSA-2424477 \"SOS mediated nucleotide exchange of RAS (SHC)\"", "Reactome:R-HSA-2485180 \"MII catalyses GDP/GTP exchange on Gt\"", "Reactome:R-HSA-2730840 \"Activation of RAC1 by VAV\"", "Reactome:R-HSA-350769 \"trans-Golgi Network Coat Activation\"", "Reactome:R-HSA-354173 \"Activation of Rap1 by cytosolic GEFs\"", "Reactome:R-HSA-379044 \"Liganded Gs-activating GPCR acts as a GEF for Gs\"", "Reactome:R-HSA-379048 \"Liganded Gq/11-activating GPCRs act as GEFs for Gq/11\"", "Reactome:R-HSA-380073 \"Liganded Gi-activating GPCR acts as a GEF for Gi\"", "Reactome:R-HSA-381727 \"RAP1A exchanges GDP for GTP\"", "Reactome:R-HSA-389348 \"Activation of Rac1 by pVav1\"", "Reactome:R-HSA-389350 \"Activation of Cdc42 by pVav1\"", "Reactome:R-HSA-392054 \"NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras\"", "Reactome:R-HSA-392195 \"Gi activation by P2Y purinoceptor 12\"", "Reactome:R-HSA-3928592 \"p190RhoGEF exchanges GTP for GDP on RHOA, activating it\"", "Reactome:R-HSA-3928612 \"KALRN exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928628 \"VAV exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928632 \"ITSN1 exchanges GTP for GDP on CDC42, activating it\"", "Reactome:R-HSA-3928633 \"bPIX exchanges GTP for GDP on RAC, activating it\"", "Reactome:R-HSA-3928642 \"TIAM1 exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-3928651 \"NGEF exchanges GTP for GDP on RHOA\"", "Reactome:R-HSA-392870 \"Gs activation by prostacyclin receptor\"", "Reactome:R-HSA-3965444 \"WNT:FZD complex promotes G-protein nucleotide exchange\"", "Reactome:R-HSA-399938 \"Activation of Rac1 by FARP2\"", "Reactome:R-HSA-399995 \"Muscarinic Acetylcholine Receptor M3 activates Gq\"", "Reactome:R-HSA-400037 \"Gi,Go Heterotrimeric G-protein complex dissociates\"", "Reactome:R-HSA-400092 \"Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins\"", "Reactome:R-HSA-4093336 \"p-TIAM1 exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-416530 \"FFAR1:FFAR1 ligands activate Gq\"", "Reactome:R-HSA-416588 \"Activation of Rho by LARG and PDZ-RhoGEF\"", "Reactome:R-HSA-418579 \"Gq activation by P2Y purinoceptor 1\"", "Reactome:R-HSA-418850 \"Activation of Cdc42\"", "Reactome:R-HSA-418856 \"Activation of Rac1\"", "Reactome:R-HSA-419166 \"GEFs activate RhoA,B,C\"", "Reactome:R-HSA-420883 \"Opsins act as GEFs for G alpha-t\"", "Reactome:R-HSA-428535 \"Activation of RAC1 by SOS\"", "Reactome:R-HSA-428750 \"Gq activation by TP receptor\"", "Reactome:R-HSA-428917 \"G13 activation by TP receptor\"", "Reactome:R-HSA-442273 \"VAV1 is a GEF for Rho/Rac family GTPases\"", "Reactome:R-HSA-442291 \"VAV2 is a GEF for Rho/Rac family kinases\"", "Reactome:R-HSA-442314 \"VAV3 is a GEF for Rho/Rac family kinases\"", "Reactome:R-HSA-442732 \"NMDA-activated RASGRF1 activates RAS\"", "Reactome:R-HSA-445064 \"Activation of Rac1 by VAV2\"", "Reactome:R-HSA-5218829 \"VEGF induces CDC42 activation by unknown mechanism\"", "Reactome:R-HSA-5218839 \"DOCK180:ELMO exchanges GTP for GDP, activating RAC1\"", "Reactome:R-HSA-5218850 \"VAV exchanges GTP for GDP on RAC1, activating it\"", "Reactome:R-HSA-5617816 \"RAB3IP stimulates nucleotide exchange on RAB8A\"", "Reactome:R-HSA-5623508 \"GBF1 stimulates nucleotide exchange on ARF4\"", "Reactome:R-HSA-5623521 \"RAB3IP stimulates nucleotide exchange on RAB8A\"", "Reactome:R-HSA-5637806 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)\"", "Reactome:R-HSA-5637808 \"SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)\"", "Reactome:R-HSA-5654392 \"Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654402 \"Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654413 \"Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654426 \"Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654600 \"Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654618 \"Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654647 \"Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5654663 \"Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655241 \"Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655277 \"Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655326 \"Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5655347 \"Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange\"", "Reactome:R-HSA-5672965 \"RAS GEFs promote RAS nucleotide exchange\"", "Reactome:R-HSA-5686071 \"GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-5686318 \"GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS\"", "Reactome:R-HSA-5694409 \"Nucleotide exchange on RAB1\"", "Reactome:R-HSA-6807868 \"GBF1 stimulates ARF nucleotide exchange\"", "Reactome:R-HSA-6811414 \"GBF1 stimulates nucleotide exchange on ARF\"", "Reactome:R-HSA-6811418 \"ARFGAPs stimulate ARF GTPase activity at the Golgi membrane\"", "Reactome:R-HSA-6811429 \"RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange\"", "Reactome:R-HSA-749453 \"Liganded Gz-activating GPCR acts as a GEF for Gz\"", "Reactome:R-HSA-751029 \"Liganded G12/13-activating GPCR acts as a GEF for G12/13\"", "Reactome:R-HSA-825631 \"Glucagon:GCGR mediates GTP-GDP exchange\"", "Reactome:R-HSA-8848618 \"Activation of RAC1 by the PXN:CRK complex\"", "Reactome:R-HSA-8850041 \"RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18\"", "Reactome:R-HSA-8851827 \"RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1\"", "Reactome:R-HSA-8851877 \"RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET\"", "Reactome:R-HSA-8851899 \"RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET\"", "Reactome:R-HSA-8875318 \"RAB3 GEFs exchange GTP for GDP on RAB3A\"", "Reactome:R-HSA-8875320 \"RAB5 GEFs exchange GTP for GDP on RAB5\"", "Reactome:R-HSA-8875568 \"RAPGEF1 activates RAP1\"", "Reactome:R-HSA-8875591 \"DOCK7 activates RAC1\"", "Reactome:R-HSA-8876188 \"DENND4s exchange GTP for GDP on RAB10\"", "Reactome:R-HSA-8876190 \"RAB8 GEFs exchange GTP for GDP on RAB8\"", "Reactome:R-HSA-8876191 \"RAB9 GEFs exchange GTP for GDP on RAB9\"", "Reactome:R-HSA-8876193 \"RIC1-RGP1 exchanges GTP for GDP on RAB6\"", "Reactome:R-HSA-8876454 \"DENND3 exchanges GTP for GDP on RAB12\"", "Reactome:R-HSA-8876615 \"RAB13 GEFs exchange GTP for GDP on RAB13\"", "Reactome:R-HSA-8876616 \"DENND6A,B exchange GTP for GDP on RAB14\"", "Reactome:R-HSA-8876837 \"RAB21 GEFs exchange GTP for GDP on RAB21\"", "Reactome:R-HSA-8877308 \"MADD exchanges GTP for GDP on RAB27\"", "Reactome:R-HSA-8877311 \"RAB31 GEFs exchange GTP for GDP on RAB31\"", "Reactome:R-HSA-8877451 \"MON1:CCZ1 exchanges GTP for GDP on RAB7\"", "Reactome:R-HSA-8877475 \"TRAPPC complexes exchange GTP for GDP on RAB1\"", "Reactome:R-HSA-8877612 \"DENND1s exchange GTP for GDP on RAB35\"", "Reactome:R-HSA-8877760 \"HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38\"", "Reactome:R-HSA-8877813 \"DENND5A,B exchange GTP for GDP on RAB39\"", "Reactome:R-HSA-8877998 \"RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18\"", "Reactome:R-HSA-8964604 \"CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated\"", "Reactome:R-HSA-8980691 \"RHOA GEFs activate RHOA\"", "Reactome:R-HSA-8982637 \"Opsins binds G alpha-t\"", "Reactome:R-HSA-8982640 \"G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)\"", "Reactome:R-HSA-9013023 \"RHOB GEFs activate RHOB\"", "Reactome:R-HSA-9013109 \"RHOC GEFs activate RHOC\"", "Reactome:R-HSA-9013143 \"RAC1 GEFs activate RAC1\"", "Reactome:R-HSA-9013159 \"CDC42 GEFs activate CDC42\"", "Reactome:R-HSA-9013435 \"RHOD auto-activates\"", "Reactome:R-HSA-9014296 \"RAC2 GEFs activate RAC2\"", "Reactome:R-HSA-9014433 \"RHOG GEFs activate RHOG\"", "Reactome:R-HSA-9017491 \"RHOJ GEFs activate RHOJ\"", "Reactome:R-HSA-9018747 \"RHOQ GEFs activate RHOQ\"", "Reactome:R-HSA-9018768 \"RHOU auto-activates\"", "Reactome:R-HSA-9018804 \"RAC3 GEFs activate RAC3\"", "Reactome:R-HSA-9018817 \"RHOT1 GEFs activate RHOT1\"", "Reactome:R-HSA-9018825 \"RHOT2 GEFs activate RHOT2\"", "Reactome:R-HSA-9026891 \"NTRK2 activates RAS signaling through SHC1\"", "Reactome:R-HSA-9029158 \"EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS\"", "Reactome:R-HSA-9032067 \"NTRK2 activates RAS signaling through FRS2\"", "Reactome:R-HSA-9032798 \"DOCK3 activates RAC1\"", "Reactome:R-HSA-9033292 \"NTRK2 and CDK5 promote activation of RAC1 by TIAM1\"", "Reactome:R-HSA-9036301 \"ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s\"", "Reactome:R-HSA-939265 \"Activation of Rap1 by membrane-associated GEFs\"", "Reactome:R-HSA-9607304 \"SOS1-mediated nucleotide exchange of RAS downstream of FLT3\"", "Reactome:R-HSA-9619803 \"p-S516-ARHGEF7 activates RAC1\"", "Reactome:R-HSA-9624845 \"RCC1 stimulates GDP to GTP exchange on RAN\"", "Reactome:R-HSA-9634418 \"RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1\"", "Reactome:R-HSA-9639286 \"RRAGC,D exchanges GTP for GDP\"", "Reactome:R-HSA-9640167 \"RRAGA,B exchanges GDP for GTP\"", "Reactome:R-HSA-9660824 \"ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs\"", "Reactome:R-HSA-9664991 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants\"", "Reactome:R-HSA-9665009 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR\"", "Reactome:R-HSA-9665404 \"RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1\"", "Reactome:R-HSA-9665408 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2\"", "Reactome:R-HSA-9665700 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants\"", "Reactome:R-HSA-9665707 \"RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR\"", "Reactome:R-HSA-9666428 \"DOCK180 exchanges GTP for GDP on RAC1:GDP\"", "Reactome:R-HSA-9666430 \"p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP\"", "Reactome:R-HSA-9670436 \"p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS\"", "Reactome:R-HSA-9672163 \"SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers\"", "Reactome:R-HSA-9672170 \"SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors\"", "Reactome:R-HSA-9680385 \"CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS\"", "Reactome:R-HSA-9693111 \"RHOF auto-activates\"", "Reactome:R-HSA-9695853 \"FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS\"", "Reactome:R-HSA-9703441 \"SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants\"", "Reactome:R-HSA-9751201 \"p-VAV1,2,3 exchange 6TGTP for GDP on RAC1\"" ] } } }, { "id": "GO:0005457", "name": "GDP-fucose transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5653596 \"Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen\"", "Reactome:R-HSA-742345 \"SLC35C1 transports GDP-Fuc from cytosol to Golgi lumen\"" ], "previous": [ "Reactome:R-HSA-5653596 \"Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen\"", "Reactome:R-HSA-742345 \"SLC35C1 transport GDP-Fuc from cytosol to Golgi lumen\"" ] } } }, { "id": "GO:0005476", "name": "carnitine:O-acyl-L-carnitine antiporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-200424 \"Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane\"", "Reactome:R-HSA-9971094 \"SLC25A20 exports excess acyl-CAR\"" ], "previous": [ "Reactome:R-HSA-200424 \"Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane\"" ] } } }, { "id": "GO:0008080", "name": "N-acetyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2468039 \"Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2\"", "Reactome:R-HSA-2473152 \"Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2\"", "Reactome:R-HSA-6790987 \"NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842\"", "Reactome:R-HSA-9636560 \"Eis acetylates DUSP16\"", "Reactome:R-HSA-9913373 \"AAC(6)-Ib acetylates ciprofloxacin\"", "Reactome:R-HSA-9971629 \"Unknown NAT N-acetylates kynurenine\"" ], "previous": [ "Reactome:R-HSA-2468039 \"Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2\"", "Reactome:R-HSA-2473152 \"Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2\"", "Reactome:R-HSA-6790987 \"NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842\"", "Reactome:R-HSA-9636560 \"Eis acetylates DUSP16\"", "Reactome:R-HSA-9913373 \"AAC(6)-Ib acetylates ciprofloxacin\"" ] } } }, { "id": "GO:0008106", "name": "alcohol dehydrogenase (NADP+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.2", "MetaCyc:ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN", "Reactome:R-HSA-192033 \"4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one\"", "Reactome:R-HSA-192036 \"5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol\"", "Reactome:R-HSA-192067 \"4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one\"", "Reactome:R-HSA-192160 \"5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol\"", "Reactome:R-HSA-193746 \"4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one\"", "Reactome:R-HSA-193755 \"4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one\"", "Reactome:R-HSA-193758 \"5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol\"", "Reactome:R-HSA-193781 \"5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol\"", "Reactome:R-HSA-193800 \"5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol\"", "Reactome:R-HSA-193821 \"4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one\"", "Reactome:R-HSA-193824 \"4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one\"", "Reactome:R-HSA-193841 \"5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol\"", "Reactome:R-HSA-198845 \"CYB5A:heme reduces Asc.- to AscH-\"", "Reactome:R-HSA-2855252 \"AKRs reduce RBP2:atRAL to RBP2:atROL\"", "Reactome:R-HSA-5423637 \"AKR dimers reduce AFBDHO to AFBDOH\"", "Reactome:R-HSA-5692232 \"AKR1A1 oxidises BaPtDHD to BaP-7,8-dione\"", "Reactome:R-HSA-9027531 \"Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA\"", "Reactome:R-HSA-9027562 \"Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA\"", "Reactome:R-HSA-9027598 \"Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3\"", "Reactome:R-HSA-9027600 \"Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3\"", "Reactome:R-HSA-9937340 \"DHRSX reduces dolichal to dolichol\"", "RHEA:15937", "RHEA:20193", "RHEA:38111", "RHEA:54916", "RHEA:54920", "RHEA:58328", "RHEA:58332", "RHEA:58336", "RHEA:58364", "RHEA:58368", "RHEA:58372", "RHEA:58376", "RHEA:58380", "RHEA:58384", "RHEA:58400", "RHEA:58404", "RHEA:58408", "RHEA:58416", "RHEA:58420", "RHEA:58424", "RHEA:58428", "RHEA:58432", "RHEA:58436", "RHEA:58668", "RHEA:59448", "RHEA:59452", "RHEA:59456", "RHEA:59460", "RHEA:59464", "RHEA:59928", "RHEA:63496", "RHEA:64708", "RHEA:64712", "RHEA:66448", "RHEA:76611", "RHEA:80723", "RHEA:84055", "RHEA:84059", "RHEA:84063" ], "previous": [ "EC:1.1.1.2", "MetaCyc:ALCOHOL-DEHYDROGENASE-NADPORNOP+-RXN", "Reactome:R-HSA-192033 \"4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one\"", "Reactome:R-HSA-192036 \"5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol\"", "Reactome:R-HSA-192067 \"4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one\"", "Reactome:R-HSA-192160 \"5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol\"", "Reactome:R-HSA-193746 \"4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one\"", "Reactome:R-HSA-193755 \"4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one\"", "Reactome:R-HSA-193758 \"5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol\"", "Reactome:R-HSA-193781 \"5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol\"", "Reactome:R-HSA-193800 \"5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol\"", "Reactome:R-HSA-193821 \"4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one\"", "Reactome:R-HSA-193824 \"4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one\"", "Reactome:R-HSA-193841 \"5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol\"", "Reactome:R-HSA-198845 \"CYB5A:heme reduces Asc.- to AscH-\"", "Reactome:R-HSA-2855252 \"AKRs reduce RBP2:atRAL to RBP2:atROL\"", "Reactome:R-HSA-5423637 \"AKR dimers reduce AFBDHO to AFBDOH\"", "Reactome:R-HSA-5692232 \"AKR1A1 oxidises BaPtDHD to BaP-7,8-dione\"", "Reactome:R-HSA-9027531 \"Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA\"", "Reactome:R-HSA-9027562 \"Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA\"", "Reactome:R-HSA-9027598 \"Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3\"", "Reactome:R-HSA-9027600 \"Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3\"", "Reactome:R-HSA-9937340 \"DHRSX reduces dolichal to dolichol\"", "RHEA:15937" ] } } }, { "id": "GO:0008107", "name": "galactoside 2-alpha-L-fucosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.69", "MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN", "Reactome:R-HSA-9036987 \"FUT2 transfers Fuc to Type 1 chains to form H antigen-sec\"", "Reactome:R-HSA-9603982 \"FUT2 transfers Fuc to LeA to form LeB\"", "Reactome:R-HSA-9603983 \"FUT2 transfers Fuc to LeX to form LeY\"", "RHEA:32175", "RHEA:48792", "RHEA:50664" ], "previous": [ "EC:2.4.1.69", "MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN", "Reactome:R-HSA-9036987 \"FUT2 transfers Fuc to Type 1 chains to form H antigen-sec\"", "Reactome:R-HSA-9603982 \"FUT2 transfers Fuc to LeA to form LeB\"", "Reactome:R-HSA-9603983 \"FUT2 transfers Fuc to LeX to form LeY\"", "RHEA:48792", "RHEA:50664" ] } } }, { "id": "GO:0008118", "name": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.6", "MetaCyc:2.4.99.6-RXN", "RHEA:18913", "RHEA:52316", "RHEA:56264", "RHEA:65432", "RHEA:80751", "RHEA:80755" ], "previous": [ "EC:2.4.3.6", "MetaCyc:2.4.99.6-RXN", "RHEA:52316", "RHEA:56264", "RHEA:65432", "RHEA:80755" ] } } }, { "id": "GO:0008177", "name": "succinate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.3.5.1", "KEGG_REACTION:R02164", "MetaCyc:RXN-14971", "Reactome:R-HSA-163213 \"Transfer of electrons through the succinate dehydrogenase complex\"", "Reactome:R-HSA-70994 \"SDH complex dehydrogenates succinate\"", "RHEA:13713", "RHEA:27834", "RHEA:29215", "RHEA:33863", "RHEA:40523", "RHEA:75711" ], "previous": [ "EC:1.3.5.1", "KEGG_REACTION:R02164", "MetaCyc:RXN-14971", "Reactome:R-HSA-163213 \"Transfer of electrons through the succinate dehydrogenase complex\"", "Reactome:R-HSA-70994 \"SDH complex dehydrogenates succinate\"", "RHEA:13713", "RHEA:27834", "RHEA:40523", "RHEA:75711" ] } } }, { "id": "GO:0008233", "name": "peptidase activity", "changes": { "xrefs": { "current": [ "EC:3.4.-.-", "Reactome:R-HSA-205112 \"gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6\"", "Reactome:R-HSA-3000243 \"Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl\"", "Reactome:R-HSA-3000263 \"TCN2:RCbl is degraded to release RCbl\"", "Reactome:R-HSA-3065958 \"An unknown protease degrades ACACA\"", "Reactome:R-HSA-3065959 \"An unknown protease degrades hCBXs\"", "Reactome:R-HSA-3139027 \"Maturation of HIV Virion\"", "Reactome:R-HSA-376149 \"Proteolytic processing of SLIT\"", "Reactome:R-HSA-4167501 \"An unknown protease degrades ACACB\"", "Reactome:R-HSA-448678 \"CTSG cleaves CASP1(1-404)\"", "Reactome:R-HSA-5655483 \"USP1 autocleavage\"", "Reactome:R-HSA-5684864 \"NAPSA, CTSH, PGA3-5 cleave pro-SFTPB\"", "Reactome:R-HSA-5685902 \"NAPSA, CTSH, PGA3-5 cleave pro-SFTPC\"", "Reactome:R-HSA-6803060 \"DCD(63-110) is processed to DCD(63-109)\"", "Reactome:R-HSA-9935547 \"Lysosomal degradation of ubiquitinated CDH1\"" ], "previous": [ "EC:3.4.-.-", "Reactome:R-HSA-205112 \"gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6\"", "Reactome:R-HSA-3000243 \"Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl\"", "Reactome:R-HSA-3000263 \"TCN2:RCbl is degraded to release RCbl\"", "Reactome:R-HSA-3065958 \"An unknown protease degrades ACACA\"", "Reactome:R-HSA-3065959 \"An unknown protease degrades hCBXs\"", "Reactome:R-HSA-3139027 \"Maturation of HIV Virion\"", "Reactome:R-HSA-376149 \"Proteolytic processing of SLIT\"", "Reactome:R-HSA-4167501 \"An unknown protease degrades ACACB\"", "Reactome:R-HSA-448678 \"CTSG cleaves CASP1(1-404)\"", "Reactome:R-HSA-5655483 \"USP1 autocleavage\"", "Reactome:R-HSA-5684864 \"NAPSA, CTSH, PGA3-5 cleave pro-SFTPB\"", "Reactome:R-HSA-5685902 \"NAPSA, CTSH, PGA3-5 cleave pro-SFTPC\"", "Reactome:R-HSA-6803060 \"DCD(63-110) is processed to DCD(63-109)\"", "Reactome:R-HSA-9935547 \"Lysosomal degradation of ubiqutinated CDH1\"" ] } } }, { "id": "GO:0008252", "name": "nucleotidase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "RHEA:22140" ] } } }, { "id": "GO:0008253", "name": "5'-nucleotidase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.5", "MetaCyc:5-NUCLEOTID-RXN", "Reactome:R-HSA-109278 \"NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP\"", "Reactome:R-HSA-109291 \"CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]\"", "Reactome:R-HSA-109380 \"(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)\"", "Reactome:R-HSA-109387 \"(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]\"", "Reactome:R-HSA-109415 \"AMP + H2O => adenosine + orthophosphate [NT5C1B]\"", "Reactome:R-HSA-109449 \"(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)\"", "Reactome:R-HSA-109470 \"(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)\"", "Reactome:R-HSA-109480 \"TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]\"", "Reactome:R-HSA-109514 \"TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]\"", "Reactome:R-HSA-5694126 \"NT5C3B hydrolyses 7MGP to 7MG\"", "Reactome:R-HSA-74248 \"(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)\"", "Reactome:R-HSA-8940070 \"NT5E:Zn2+ hydrolyses NAD+\"", "Reactome:R-HSA-8940074 \"NT5E:Zn2+ hydrolyses NMN\"", "Reactome:R-HSA-9755078 \"NT5C2 tetramer dephosphorylates RBV-MP\"", "RHEA:12484", "RHEA:22140", "RHEA:27714", "RHEA:27718", "RHEA:29359", "RHEA:29375", "RHEA:30815" ], "previous": [ "EC:3.1.3.5", "MetaCyc:5-NUCLEOTID-RXN", "Reactome:R-HSA-109278 \"NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP\"", "Reactome:R-HSA-109291 \"CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]\"", "Reactome:R-HSA-109380 \"(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)\"", "Reactome:R-HSA-109387 \"(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)\"", "Reactome:R-HSA-109415 \"AMP + H2O => adenosine + orthophosphate [NT5C1B]\"", "Reactome:R-HSA-109449 \"(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)\"", "Reactome:R-HSA-109470 \"(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)\"", "Reactome:R-HSA-109480 \"TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]\"", "Reactome:R-HSA-109514 \"TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]\"", "Reactome:R-HSA-5694126 \"NT5C3B hydrolyses 7MGP to 7MG\"", "Reactome:R-HSA-74248 \"(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)\"", "Reactome:R-HSA-8940070 \"NT5E:Zn2+ hydrolyses NAD+\"", "Reactome:R-HSA-8940074 \"NT5E:Zn2+ hydrolyses NMN\"", "Reactome:R-HSA-9755078 \"NT5C2 tetramer dephosphorylates RBV-MP\"", "RHEA:12484", "RHEA:27714", "RHEA:27718", "RHEA:29359", "RHEA:29375", "RHEA:30815" ] } } }, { "id": "GO:0008483", "name": "transaminase activity", "changes": { "xrefs": { "current": [ "EC:2.6.1.-", "Reactome:R-HSA-1237102 \"Transamination of MOB to methionine\"", "Reactome:R-HSA-9972889 \"AADAT transaminates 3HKYN to xanthurenate\"" ], "previous": [ "EC:2.6.1.-", "Reactome:R-HSA-1237102 \"Transamination of MOB to methionine\"" ] } } }, { "id": "GO:0008650", "name": "rRNA (uridine-2'-O-ribose)-methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6793127 \"MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine\"", "RHEA:42720", "RHEA:42728", "RHEA:43092", "RHEA:47760", "RHEA:47764", "RHEA:54152" ], "previous": [ "Reactome:R-HSA-6793127 \"MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine\"", "RHEA:42720", "RHEA:43092", "RHEA:47760", "RHEA:47764", "RHEA:54152" ] } } }, { "id": "GO:0008670", "name": "2,4-dienoyl-CoA reductase (NADPH) activity", "changes": { "xrefs": { "current": [ "EC:1.3.1.34", "MetaCyc:RXN-20994", "MetaCyc:RXN-20995", "RHEA:12136", "RHEA:45232", "RHEA:53296", "RHEA:53708" ], "previous": [ "EC:1.3.1.34", "MetaCyc:RXN-20994", "MetaCyc:RXN-20995", "RHEA:12136", "RHEA:45232" ] } } }, { "id": "GO:0008718", "name": "D-amino-acid dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.4.5.1", "MetaCyc:RXN-11193", "RHEA:18125", "RHEA:30091", "RHEA:37219", "RHEA:37255", "RHEA:43572", "RHEA:45996", "RHEA:55948" ], "previous": [ "EC:1.4.5.1", "MetaCyc:RXN-11193", "RHEA:18125", "RHEA:37219", "RHEA:37255", "RHEA:43572", "RHEA:45996", "RHEA:55948" ] } } }, { "id": "GO:0008735", "name": "L-carnitine CoA-transferase activity", "changes": { "xrefs": { "current": [ "EC:2.8.3.21", "RHEA:28526" ], "previous": [ "EC:2.8.3.21", "RHEA:28338", "RHEA:28526" ] } } }, { "id": "GO:0008753", "name": "NADPH dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.6.5.10", "KEGG_REACTION:R07359", "MetaCyc:RXN0-271", "MetaCyc:RXN0-7385", "RHEA:46164", "RHEA:61980", "RHEA:63492", "RHEA:83239", "RHEA:83247" ], "previous": [ "EC:1.6.5.10", "KEGG_REACTION:R07359", "MetaCyc:RXN0-271", "MetaCyc:RXN0-7385", "RHEA:46164", "RHEA:61980", "RHEA:63492", "RHEA:83239" ] } } }, { "id": "GO:0008761", "name": "UDP-N-acetylglucosamine 2-epimerase activity", "changes": { "xrefs": { "current": [ "EC:5.1.3.14", "MetaCyc:UDPGLCNACEPIM-RXN", "Reactome:R-HSA-4085021 \"GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP\"", "Reactome:R-HSA-4088338 \"Defective GNE does not hydrolyse UDP-GlcNAc\"", "RHEA:17213" ], "previous": [ "EC:5.1.3.14", "MetaCyc:UDPGLCNACEPIM-RXN", "Reactome:R-HSA-4085021 \"GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP\"", "Reactome:R-HSA-4088338 \"Defective GNE does not hydrolyse UDP-GlcNAc\"", "RHEA:17213" ] } } }, { "id": "GO:0008874", "name": "gluconate 5-dehydrogenase [NAD(P)+] activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.69", "MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN", "RHEA:23936", "RHEA:23940" ], "previous": [ "EC:1.1.1.69", "MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN" ] } } }, { "id": "GO:0008922", "name": "long-chain fatty acid [acyl-carrier-protein] ligase activity", "changes": { "xrefs": { "current": [ "EC:6.2.1.20", "KEGG_REACTION:R07325", "MetaCyc:ACYLACPSYNTH-RXN", "RHEA:10696", "RHEA:45588", "RHEA:59164", "RHEA:63628", "RHEA:64888" ], "previous": [ "EC:6.2.1.20", "KEGG_REACTION:R07325", "MetaCyc:ACYLACPSYNTH-RXN", "RHEA:10696", "RHEA:45588", "RHEA:63628", "RHEA:64888" ] } } }, { "id": "GO:0008924", "name": "L-malate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.1.5.4", "MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN", "MetaCyc:RXNI-3", "RHEA:29083", "RHEA:29087", "RHEA:30095", "RHEA:46012" ], "previous": [ "EC:1.1.5.4", "MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN", "MetaCyc:RXNI-3", "RHEA:29083", "RHEA:30095", "RHEA:46012" ] } } }, { "id": "GO:0008962", "name": "phosphatidylglycerophosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.1.3.27", "MetaCyc:PGPPHOSPHA-RXN", "Reactome:R-HSA-1483197 \"PTPMT1 dephosphorylates PGP to PG\"", "RHEA:16725", "RHEA:33752", "RHEA:42305" ], "previous": [ "EC:3.1.3.27", "MetaCyc:PGPPHOSPHA-RXN", "Reactome:R-HSA-1483197 \"PTPMT1 dephosphorylates PGP to PG\"", "RHEA:16725", "RHEA:33752" ] } } }, { "id": "GO:0008970", "name": "glycerophospholipid phospholipase A1 activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.32", "MetaCyc:PHOSPHOLIPASE-A1-RXN", "Reactome:R-HSA-1482827 \"PC is hydrolyzed to 2-acyl LPC by PLA2G4C\"", "Reactome:R-HSA-1482828 \"PE is hydrolyzed to 2-acyl LPE by PLA2[4]\"", "Reactome:R-HSA-1482847 \"PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)\"", "Reactome:R-HSA-1482862 \"PC is hydrolysed to 2-acyl LPC by PLA2[7]\"", "Reactome:R-HSA-1482892 \"PE is hydrolyzed to 2-acyl LPE by PLA2G4C\"", "Reactome:R-HSA-1482920 \"PG is hydrolyzed to 2-acyl LPG by PLA2[14]\"", "Reactome:R-HSA-1482932 \"PI is hydrolyzed to 2-acyl LPI by PLA2[13]\"", "Reactome:R-HSA-5694485 \"ABHD3 hydrolyses LPC(14:0) to 1AGPC\"", "Reactome:R-HSA-8869425 \"PLA1A hydrolyses PS to 2-acyl LPS\"", "RHEA:18689", "RHEA:35263", "RHEA:38783", "RHEA:38787", "RHEA:40487", "RHEA:41167", "RHEA:41171", "RHEA:41207", "RHEA:42212", "RHEA:43968", "RHEA:44408", "RHEA:44648", "RHEA:53496", "RHEA:56448", "RHEA:62032", "RHEA:62044", "RHEA:62464", "RHEA:62480", "RHEA:62484", "RHEA:62488", "RHEA:66708", "RHEA:67424", "RHEA:67428", "RHEA:73967", "RHEA:73971", "RHEA:73975", "RHEA:74103", "RHEA:74159", "RHEA:74163", "RHEA:74247", "RHEA:74251", "RHEA:76971", "RHEA:76975", "RHEA:76979", "RHEA:76983" ], "previous": [ "EC:3.1.1.32", "MetaCyc:PHOSPHOLIPASE-A1-RXN", "Reactome:R-HSA-1482827 \"PC is hydrolyzed to 2-acyl LPC by PLA2G4C\"", "Reactome:R-HSA-1482828 \"PE is hydrolyzed to 2-acyl LPE by PLA2[4]\"", "Reactome:R-HSA-1482847 \"PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)\"", "Reactome:R-HSA-1482862 \"PC is hydrolysed to 2-acyl LPC by PLA2[7]\"", "Reactome:R-HSA-1482892 \"PE is hydrolyzed to 2-acyl LPE by PLA2G4C\"", "Reactome:R-HSA-1482920 \"PG is hydrolyzed to 2-acyl LPG by PLA2[14]\"", "Reactome:R-HSA-1482932 \"PI is hydrolyzed to 2-acyl LPI by PLA2[13]\"", "Reactome:R-HSA-5694485 \"ABHD3 hydrolyses LPC(14:0) to 1AGPC\"", "Reactome:R-HSA-8869425 \"PLA1A hydrolyses PS to 2-acyl LPS\"", "RHEA:18689", "RHEA:35263", "RHEA:42212", "RHEA:44408", "RHEA:44648", "RHEA:62032", "RHEA:67424", "RHEA:67428" ] } } }, { "id": "GO:0010326", "name": "L-methionine:oxo-acid transaminase activity", "changes": { "xrefs": { "current": [ "EC:2.6.1.88", "MetaCyc:R15-RXN", "RHEA:31763", "RHEA:47084", "RHEA:47800" ], "previous": [ "EC:2.6.1.88", "MetaCyc:R15-RXN", "RHEA:31763", "RHEA:47800" ] } } }, { "id": "GO:0010945", "name": "coenzyme A diphosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.77", "MetaCyc:RXN-10811", "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"", "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"", "Reactome:R-HSA-9837354 \"NUDT8 hydrolyzes CoA-SH to PPANT\"", "RHEA:49976", "RHEA:49980", "RHEA:50016", "RHEA:50020", "RHEA:50024", "RHEA:50028", "RHEA:50032", "RHEA:50036", "RHEA:50040", "RHEA:50044", "RHEA:64988", "RHEA:64992", "RHEA:65564", "RHEA:65568", "RHEA:67464", "RHEA:67468", "RHEA:67472", "RHEA:67524", "RHEA:67528", "RHEA:67532", "RHEA:67536", "RHEA:67540", "RHEA:67544" ], "previous": [ "EC:3.6.1.77", "MetaCyc:RXN-10811", "Reactome:R-HSA-6809354 \"NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT\"", "Reactome:R-HSA-6810474 \"NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT\"", "Reactome:R-HSA-9837354 \"NUDT8 hydrolyzes CoA-SH to PPANT\"", "RHEA:50044", "RHEA:64988" ] } } }, { "id": "GO:0015020", "name": "glucuronosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.17", "MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN", "Reactome:R-HSA-158546 \"UGTs glucuronate APAP to APAP-GlcA\"", "Reactome:R-HSA-159179 \"UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG\"", "Reactome:R-HSA-159194 \"UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG\"", "Reactome:R-HSA-174916 \"Formation of N-glucuronides\"", "Reactome:R-HSA-174931 \"UGTs transfer GlcA from UDP-GlcA to O-centre substrates\"", "Reactome:R-HSA-2162099 \"abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP\"", "Reactome:R-HSA-5604954 \"Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL\"", "Reactome:R-HSA-5604975 \"Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL\"", "Reactome:R-HSA-5617143 \"B4GAT1:LARGE transfers initial GlcA to matriglycan chain\"", "Reactome:R-HSA-8941701 \"UGT1A10 transfers GlcA from UDP-GlcA to GCTN\"", "Reactome:R-HSA-9036102 \"Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG\"", "Reactome:R-HSA-9036104 \"Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG\"", "Reactome:R-HSA-9632038 \"UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG\"", "Reactome:R-HSA-9632039 \"UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG\"", "Reactome:R-HSA-9638097 \"LARGE1,2 elongates matriglycan chain with GlcA\"", "Reactome:R-HSA-9749977 \"UGT1A6 glucuronates ST\"", "Reactome:R-HSA-9756134 \"UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL\"", "Reactome:R-HSA-9756156 \"UGT1A3 lactonizes ATV to ATVL\"", "Reactome:R-HSA-9756183 \"UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL\"", "Reactome:R-HSA-9758661 \"UGT2B7,2B17,1A3 glucuronidates PRED metabolites\"", "RHEA:21032", "RHEA:30631", "RHEA:31483", "RHEA:52448", "RHEA:52452", "RHEA:52456", "RHEA:52460", "RHEA:52464", "RHEA:52468", "RHEA:52472", "RHEA:52476", "RHEA:52880", "RHEA:52916", "RHEA:52920", "RHEA:52924", "RHEA:52940", "RHEA:52944", "RHEA:52948", "RHEA:52952", "RHEA:52956", "RHEA:52960", "RHEA:52964", "RHEA:52968", "RHEA:53000", "RHEA:53004", "RHEA:53028", "RHEA:53032", "RHEA:53036", "RHEA:53040", "RHEA:53048", "RHEA:53052", "RHEA:53060", "RHEA:53064", "RHEA:53068", "RHEA:53072", "RHEA:53080", "RHEA:53388", "RHEA:55768", "RHEA:55776", "RHEA:55780", "RHEA:55784", "RHEA:55836", "RHEA:55840", "RHEA:55844", "RHEA:56160", "RHEA:56508", "RHEA:63588", "RHEA:63612", "RHEA:63616", "RHEA:63692", "RHEA:63696", "RHEA:63700", "RHEA:63704", "RHEA:63716", "RHEA:63720", "RHEA:63724", "RHEA:63728", "RHEA:63732", "RHEA:63744", "RHEA:63748", "RHEA:74563", "RHEA:75099", "RHEA:79067", "RHEA:79071", "RHEA:79075" ], "previous": [ "EC:2.4.1.17", "MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN", "Reactome:R-HSA-158546 \"UGTs glucuronate APAP to APAP-GlcA\"", "Reactome:R-HSA-159179 \"UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG\"", "Reactome:R-HSA-159194 \"UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG\"", "Reactome:R-HSA-174916 \"Formation of N-glucuronides\"", "Reactome:R-HSA-174931 \"UGTs transfer GlcA from UDP-GlcA to O-centre substrates\"", "Reactome:R-HSA-2162099 \"abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP\"", "Reactome:R-HSA-5604954 \"Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL\"", "Reactome:R-HSA-5604975 \"Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL\"", "Reactome:R-HSA-5617143 \"B4GAT1:LARGE transfers initial GlcA to matriglycan chain\"", "Reactome:R-HSA-8941701 \"UGT1A10 transfers GlcA from UDP-GlcA to GCTN\"", "Reactome:R-HSA-9036102 \"Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG\"", "Reactome:R-HSA-9036104 \"Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG\"", "Reactome:R-HSA-9632038 \"UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG\"", "Reactome:R-HSA-9632039 \"UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG\"", "Reactome:R-HSA-9638097 \"LARGE1,2 elongates matriglycan chain with GlcA\"", "Reactome:R-HSA-9749977 \"UGT1A6 glucuronates ST\"", "Reactome:R-HSA-9756134 \"UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL\"", "Reactome:R-HSA-9756156 \"UGT1A3 lactonizes ATV to ATVL\"", "Reactome:R-HSA-9756183 \"UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL\"", "Reactome:R-HSA-9758661 \"UGT2B7,2B17,1A3 glucuronidates PRED metabolites\"", "RHEA:21032", "RHEA:63616", "RHEA:63692", "RHEA:63716", "RHEA:63720", "RHEA:63728", "RHEA:63744", "RHEA:63748", "RHEA:75099", "RHEA:79067", "RHEA:79071", "RHEA:79075" ] } } }, { "id": "GO:0015035", "name": "protein-disulfide reductase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1307802 \"MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds\"", "Reactome:R-HSA-264997 \"P4HB mediates disulfide bond formation in Proinsulin\"", "Reactome:R-HSA-9817575 \"ERO1B oxidizes P4HB\"" ], "previous": [ "Reactome:R-HSA-1307802 \"MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds\"", "Reactome:R-HSA-264997 \"P4HB mediates disulfide bond formation in Proinsulin\"", "Reactome:R-HSA-3299753 \"CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1\"", "Reactome:R-HSA-9817575 \"ERO1B oxidizes P4HB\"" ] } } }, { "id": "GO:0015199", "name": "amino-acid betaine transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-6797957 \"SLC22A4 transports BET from mitochondrial matrix to cytosol\"" ], "previous": "N/A" } } }, { "id": "GO:0015220", "name": "choline transmembrane transporter activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-429594 \"SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-444433 \"Cho transports from the extracellular space to the cytosol\"", "Reactome:R-HSA-5658483 \"Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-6797956 \"SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix\"" ], "previous": [ "Reactome:R-HSA-429594 \"SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-444433 \"Cho transports from the extracellular space to the cytosol\"", "Reactome:R-HSA-5658483 \"Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol\"", "Reactome:R-HSA-6797956 \"SLC44A1 transports Cho from cytosol to mitochondrial matrix\"" ] } } }, { "id": "GO:0015450", "name": "protein-transporting ATPase activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-1222523 \"SodB gets secreted\"" ] } } }, { "id": "GO:0016279", "name": "protein-lysine N-methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-212263 \"PRC2 trimethylates histone H3 at lysine-27\"", "Reactome:R-HSA-8865237 \"SETD6 methylates RELA in the NFkB complex\"", "Reactome:R-HSA-8931858 \"ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB\"", "Reactome:R-HSA-8931974 \"N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A\"", "Reactome:R-HSA-8932221 \"METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8\"", "Reactome:R-HSA-8932243 \"EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2\"", "Reactome:R-HSA-8932275 \"METTL22 transfers 3xCH3 from 3xAdoMet to KIN\"", "Reactome:R-HSA-8932276 \"VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP\"", "Reactome:R-HSA-8932413 \"METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1\"", "Reactome:R-HSA-9844111 \"EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP\"", "Reactome:R-HSA-9854315 \"CSKMT methylates Citrate Synthase\"", "RHEA:51000", "RHEA:51736", "RHEA:54192", "RHEA:55544", "RHEA:67108" ], "previous": [ "Reactome:R-HSA-212263 \"PRC2 trimethylates histone H3 at lysine-27\"", "Reactome:R-HSA-8865237 \"SETD6 methylates RELA in the NFkB complex\"", "Reactome:R-HSA-8931858 \"ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB\"", "Reactome:R-HSA-8931974 \"N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A\"", "Reactome:R-HSA-8932221 \"METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8\"", "Reactome:R-HSA-8932243 \"EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2\"", "Reactome:R-HSA-8932275 \"METTL22 transfers 3xCH3 from 3xAdoMet to KIN\"", "Reactome:R-HSA-8932276 \"VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP\"", "Reactome:R-HSA-8932413 \"METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1\"", "Reactome:R-HSA-9844111 \"EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP\"", "Reactome:R-HSA-9854315 \"CSKMT methylates Citrate Synthase\"", "RHEA:51736", "RHEA:54192" ] } } }, { "id": "GO:0016289", "name": "acyl-CoA hydrolase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-193385 \"Hydrolysis of choloyl-CoA to cholate and CoASH\"", "RHEA:19741", "RHEA:28542", "RHEA:31511", "RHEA:38291", "RHEA:40219", "RHEA:40575", "RHEA:40583", "RHEA:40587", "RHEA:40591", "RHEA:40595", "RHEA:45716", "RHEA:46224", "RHEA:49444", "RHEA:59936", "RHEA:66704", "RHEA:70331", "RHEA:70411", "RHEA:70415", "RHEA:70419", "RHEA:70423", "RHEA:70427", "RHEA:78267" ], "previous": [ "Reactome:R-HSA-193385 \"Hydrolysis of choloyl-CoA to cholate and CoASH\"", "RHEA:19741", "RHEA:28542", "RHEA:31511", "RHEA:40219", "RHEA:45716", "RHEA:46224", "RHEA:49444", "RHEA:59936", "RHEA:66704", "RHEA:70331", "RHEA:70411", "RHEA:70415", "RHEA:70419", "RHEA:70423", "RHEA:70427", "RHEA:78267" ] } } }, { "id": "GO:0016406", "name": "carnitine O-acyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-200410 \"CPT2 converts acylcarnitine to acyl-CoA\"", "Reactome:R-HSA-9971123 \"CRAT transfers ISB to CAR\"" ], "previous": [ "Reactome:R-HSA-200410 \"CPT2 converts acylcarnitine to acyl-CoA\"" ] } } }, { "id": "GO:0016428", "name": "tRNA (cytidine-N5)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.202", "Reactome:R-HSA-6782388 \"NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)\"", "Reactome:R-HSA-6782419 \"TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)\"", "Reactome:R-HSA-6785409 \"NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)\"", "Reactome:R-HSA-6785438 \"NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)\"", "Reactome:R-HSA-8932765 \"NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)\"", "RHEA:21124", "RHEA:42940", "RHEA:42944", "RHEA:42948", "RHEA:42952", "RHEA:42956", "RHEA:51160", "RHEA:51164", "RHEA:51172", "RHEA:51176", "RHEA:51180", "RHEA:53076", "RHEA:54136", "RHEA:54140", "RHEA:61468", "RHEA:61488", "RHEA:61584", "RHEA:61988" ], "previous": [ "EC:2.1.1.202", "Reactome:R-HSA-6782388 \"NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)\"", "Reactome:R-HSA-6782419 \"TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)\"", "Reactome:R-HSA-6785409 \"NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)\"", "Reactome:R-HSA-6785438 \"NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)\"", "Reactome:R-HSA-8932765 \"NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)\"", "RHEA:42940", "RHEA:42944", "RHEA:42948", "RHEA:42952", "RHEA:42956", "RHEA:51160", "RHEA:51164", "RHEA:51172", "RHEA:51180", "RHEA:53076", "RHEA:54136", "RHEA:54140", "RHEA:61468", "RHEA:61488", "RHEA:61988" ] } } }, { "id": "GO:0016532", "name": "superoxide dismutase copper chaperone activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-3299753 \"CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1\"" ], "previous": "N/A" } } }, { "id": "GO:0016712", "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "changes": { "xrefs": { "current": [ "EC:1.14.14.-", "EC:1.14.14.1", "MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN", "Reactome:R-HSA-194678 \"CYP51A1 demethylates LAN\"", "Reactome:R-HSA-211966 \"CYP2D6 4-hydroxylates debrisoquine\"", "RHEA:17149", "RHEA:51984", "RHEA:68160", "RHEA:75847", "RHEA:75863", "RHEA:76419" ], "previous": [ "EC:1.14.14.-", "EC:1.14.14.1", "MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN", "Reactome:R-HSA-194678 \"CYP51A1 demethylates LAN\"", "Reactome:R-HSA-211966 \"CYP2D6 4-hydroxylates debrisoquine\"", "RHEA:17149" ] } } }, { "id": "GO:0016887", "name": "ATP hydrolysis activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-159101 \"NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)\"", "Reactome:R-HSA-3371422 \"ATP hydrolysis by HSP70\"", "Reactome:R-HSA-416985 \"Trafficking of GluR2-containing AMPA receptors to synapse\"", "Reactome:R-HSA-5618093 \"ATP hydrolysis by HSP90\"", "Reactome:R-HSA-5654989 \"SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA\"", "Reactome:R-HSA-5694425 \"NSF ATPase activity dissociates cis-SNARE\"", "Reactome:R-HSA-6809015 \"NSF ATPase activity dissociates cis-SNARE at cis-Golgi\"", "Reactome:R-HSA-6811422 \"NSF ATPase activity dissociates cis-SNARE at the ER\"", "Reactome:R-HSA-6814670 \"ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation\"", "Reactome:R-HSA-6814678 \"ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN\"", "Reactome:R-HSA-6814683 \"NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN\"", "Reactome:R-HSA-8847638 \"ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane\"", "Reactome:R-HSA-8868658 \"HSPA8-mediated ATP hydrolysis promotes vesicle uncoating\"", "Reactome:R-HSA-8939203 \"HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex\"", "Reactome:R-HSA-9038161 \"Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG\"", "Reactome:R-HSA-917693 \"ESCRT Disassembly\"", "Reactome:R-HSA-9609860 \"Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP\"", "Reactome:R-HSA-9668415 \"VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope\"", "Reactome:R-HSA-9706399 \"RHOBTB3 hydrolyzes ATP\"", "Reactome:R-HSA-9749350 \"ATP-dependent release of CDT1 from the OCCM complex\"", "Reactome:R-HSA-9943614 \"CHD2-dependent H3.3 deposition at MYOG gene\"", "Reactome:R-HSA-9944087 \"CHD6-9-dependent ATP hydrolysis\"", "Reactome:R-HSA-9944091 \"NuRD hydrolyzes ATP to affect nucleosome organization\"", "Reactome:R-HSA-9948300 \"RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide\"", "Reactome:R-HSA-9949632 \"VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide\"", "Reactome:R-HSA-9955731 \"ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide\"", "RHEA:13065" ], "previous": [ "Reactome:R-HSA-159101 \"NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)\"", "Reactome:R-HSA-3371422 \"ATP hydrolysis by HSP70\"", "Reactome:R-HSA-416985 \"Trafficking of GluR2-containing AMPA receptors to synapse\"", "Reactome:R-HSA-5618093 \"ATP hydrolysis by HSP90\"", "Reactome:R-HSA-5654989 \"SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA\"", "Reactome:R-HSA-5694425 \"NSF ATPase activity dissociates cis-SNARE\"", "Reactome:R-HSA-6809015 \"NSF ATPase activity dissociates cis-SNARE at cis-Golgi\"", "Reactome:R-HSA-6811422 \"NSF ATPase activity dissociates cis-SNARE at the ER\"", "Reactome:R-HSA-6814670 \"ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation\"", "Reactome:R-HSA-6814678 \"ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN\"", "Reactome:R-HSA-6814683 \"NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN\"", "Reactome:R-HSA-8847638 \"ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane\"", "Reactome:R-HSA-8868658 \"HSPA8-mediated ATP hydrolysis promotes vesicle uncoating\"", "Reactome:R-HSA-8939203 \"HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex\"", "Reactome:R-HSA-9038161 \"Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG\"", "Reactome:R-HSA-917693 \"ESCRT Disassembly\"", "Reactome:R-HSA-9609860 \"Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP\"", "Reactome:R-HSA-9668415 \"VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope\"", "Reactome:R-HSA-9706399 \"RHOBTB3 hydrolyzes ATP\"", "Reactome:R-HSA-9749350 \"ATP-dependent release of CDT1 from the OCCM complex\"", "Reactome:R-HSA-9948300 \"RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide\"", "Reactome:R-HSA-9949632 \"VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide\"", "Reactome:R-HSA-9955731 \"ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide\"", "RHEA:13065" ] } } }, { "id": "GO:0017060", "name": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.1.65", "MetaCyc:2.4.1.65-RXN", "Reactome:R-HSA-5693925 \"FUT3 transfers L-fucose to Gal1,3GlcNAc\"", "Reactome:R-HSA-9603986 \"FUT3 transfers Fuc to Type 1 chains to form LeA\"", "RHEA:23628", "RHEA:48328", "RHEA:48824", "RHEA:62844", "RHEA:62848" ], "previous": [ "EC:2.4.1.65", "MetaCyc:2.4.1.65-RXN", "Reactome:R-HSA-5693925 \"FUT3 transfers L-fucose to Gal1,3GlcNAc\"", "Reactome:R-HSA-9603986 \"FUT3 transfers Fuc to Type 1 chains to form LeA\"", "RHEA:23628", "RHEA:48824", "RHEA:62844", "RHEA:62848" ] } } }, { "id": "GO:0017113", "name": "dihydropyrimidine dehydrogenase (NADP+) activity", "changes": { "xrefs": { "current": [ "EC:1.3.1.2", "MetaCyc:1.3.1.2-RXN", "Reactome:R-HSA-73585 \"reduction of uracil to form dihydrouracil\"", "Reactome:R-HSA-73616 \"reduction of thymine to form 5,6-Dihydrothymine\"", "RHEA:18093" ], "previous": [ "EC:1.3.1.2", "MetaCyc:1.3.1.2-RXN", "Reactome:R-HSA-73585 \"uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+\"", "Reactome:R-HSA-73616 \"thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+\"", "RHEA:18093" ] } } }, { "id": "GO:0017128", "name": "phospholipid scramblase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9853809 \"ANO6 exposes PS, PE on the platelet membrane\"", "Reactome:R-HSA-9853849 \"Defective ANO6 does not expose PS, PE on the platelet membrane\"", "Reactome:R-HSA-9854657 \"ANO5, ANO6 expose PS, PE on endothelial cells\"" ], "previous": "N/A" } } }, { "id": "GO:0017150", "name": "tRNA dihydrouridine synthase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN0-1281", "Reactome:R-HSA-6782296 \"DUS2:EPRS reduces uridine to dihydrouridine in tRNAs\"", "RHEA:23624", "RHEA:53336", "RHEA:53340", "RHEA:53360", "RHEA:53364", "RHEA:54452" ], "previous": [ "MetaCyc:RXN0-1281", "Reactome:R-HSA-6782296 \"DUS2:EPRS reduces uridine to dihydrouridine in tRNAs\"", "RHEA:23624", "RHEA:54452" ] } } }, { "id": "GO:0018618", "name": "anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity", "changes": { "xrefs": { "current": [ "EC:1.14.12.1", "MetaCyc:1.14.12.1-RXN", "RHEA:11072", "RHEA:11076", "UM-BBD_reactionID:r0577" ], "previous": [ "EC:1.14.12.1", "MetaCyc:1.14.12.1-RXN", "UM-BBD_reactionID:r0577" ] } } }, { "id": "GO:0018812", "name": "3-hydroxyacyl-CoA dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.150", "EC:4.2.1.74", "MetaCyc:ENOYL-COA-HYDRAT-RXN", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:16105", "RHEA:30547", "RHEA:31075", "RHEA:31163", "RHEA:31171", "RHEA:31191", "RHEA:31199", "RHEA:33767", "RHEA:35347", "RHEA:35355", "RHEA:35359", "RHEA:39123", "RHEA:39139", "RHEA:40187", "RHEA:40207", "RHEA:45992", "RHEA:46348", "RHEA:46352", "RHEA:47424", "RHEA:47436", "RHEA:47452", "RHEA:52664", "RHEA:71647", "RHEA:72579", "RHEA:76647", "RHEA:78559", "RHEA:78575", "RHEA:78591", "RHEA:78603", "RHEA:78911", "RHEA:78915", "RHEA:82923", "RHEA:82959", "RHEA:82995", "RHEA:83027", "RHEA:83063", "RHEA:83067", "RHEA:83147", "RHEA:83211", "RHEA:83323", "RHEA:83359", "RHEA:83375", "RHEA:83391", "RHEA:84395", "RHEA:84399", "RHEA:84403", "RHEA:84407", "RHEA:84627", "RHEA:84631", "RHEA:84659", "RHEA:84663", "RHEA:84667", "RHEA:85127" ], "previous": [ "EC:4.2.1.150", "EC:4.2.1.74", "MetaCyc:ENOYL-COA-HYDRAT-RXN", "Reactome:R-HSA-2066778 \"Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-2066780 \"Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA\"", "Reactome:R-HSA-389986 \"trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA\"", "Reactome:R-HSA-390252 \"HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-5676637 \"PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA\"", "Reactome:R-HSA-6809263 \"EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA\"", "Reactome:R-HSA-8957389 \"RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA\"", "RHEA:16105", "RHEA:33767", "RHEA:35347", "RHEA:35355", "RHEA:35359", "RHEA:46348", "RHEA:46352", "RHEA:52664", "RHEA:71647" ] } } }, { "id": "GO:0019206", "name": "nucleoside kinase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-109671 \"deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)\"", "Reactome:R-HSA-109759 \"deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]\"", "Reactome:R-HSA-109903 \"cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]\"", "Reactome:R-HSA-110137 \"(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP\"", "Reactome:R-HSA-110138 \"AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs\"", "Reactome:R-HSA-73598 \"(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)\"", "Reactome:R-HSA-73599 \"cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]\"", "Reactome:R-HSA-73632 \"phosphorylation of 2'-Deoxythymidine to dTMP\"" ], "previous": [ "Reactome:R-HSA-109671 \"deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)\"", "Reactome:R-HSA-109759 \"deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]\"", "Reactome:R-HSA-109903 \"cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]\"", "Reactome:R-HSA-110137 \"(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP\"", "Reactome:R-HSA-110138 \"AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs\"", "Reactome:R-HSA-73598 \"(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)\"", "Reactome:R-HSA-73599 \"cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]\"", "Reactome:R-HSA-73632 \"thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]\"" ] } } }, { "id": "GO:0019789", "name": "SUMO transferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2993769 \"Transfer of SUMO3 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2993780 \"Transfer of SUMO1 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2993790 \"Transfer of SUMO2 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2997616 \"PIAS1,4 SUMOylates BRCA1 with SUMO2,3\"", "Reactome:R-HSA-2997706 \"MDM2 SUMOylates TP53 with SUMO2,3\"", "Reactome:R-HSA-2997709 \"PIAS1,4 SUMOylates BRCA1 with SUMO1\"", "Reactome:R-HSA-2997723 \"PIAS4 SUMOylates TP53BP1 with SUMO1\"", "Reactome:R-HSA-3000348 \"RANBP2 SUMOylates SP100 with SUMO2\"", "Reactome:R-HSA-3000383 \"UBE2I, HDAC7 SUMOylate PML with SUMO1\"", "Reactome:R-HSA-3000399 \"RANBP2 SUMOylates SP100 with SUMO1\"", "Reactome:R-HSA-3000411 \"RANBP2 SUMOylates PML with SUMO2\"", "Reactome:R-HSA-3000433 \"SUMOylation of PML with SUMO3\"", "Reactome:R-HSA-3000434 \"PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1\"", "Reactome:R-HSA-3000449 \"UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2\"", "Reactome:R-HSA-3108203 \"PRC1 SUMOylates CTBP1 with SUMO2,3\"", "Reactome:R-HSA-3108209 \"PRC1 SUMOylates CTBP1 with SUMO1\"", "Reactome:R-HSA-3108212 \"SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1\"", "Reactome:R-HSA-3232162 \"PIAS3 SUMOylates MITF with SUMO1\"", "Reactome:R-HSA-3234081 \"SUMOylation of TFAP2A with SUMO1\"", "Reactome:R-HSA-3234084 \"SUMOylation of TFAP2B with SUMO1\"", "Reactome:R-HSA-3234094 \"SUMOylation of TFAP2C with SUMO1\"", "Reactome:R-HSA-3247493 \"PIAS1 SUMOylates SP3 with SUMO1\"", "Reactome:R-HSA-3296126 \"CBX4, UHRF2 SUMOylate ZNF131 with SUMO1\"", "Reactome:R-HSA-3465545 \"PIAS1,3,4 SUMOylate MTA1 with SUMO2,3\"", "Reactome:R-HSA-3782535 \"TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1\"", "Reactome:R-HSA-3899291 \"SUMOylation of EP300 with SUMO1\"", "Reactome:R-HSA-3900047 \"SUMOylation of DDX17 with SUMO1\"", "Reactome:R-HSA-3900070 \"SUMOylation of MKL1 with SUMO1\"", "Reactome:R-HSA-3900177 \"SUMOylation of DDX5 with SUMO1\"", "Reactome:R-HSA-3900194 \"PIAS1 SUMOylates DDX5 with SUMO2\"", "Reactome:R-HSA-3903017 \"SUMOylation of PPARGC1A with SUMO1\"", "Reactome:R-HSA-3927824 \"PRC1 SUMOylates CASP8AP2 with SUMO1\"", "Reactome:R-HSA-3927886 \"SUMOylation of NCOR2 with SUMO1\"", "Reactome:R-HSA-3927959 \"SUMOylation of CREBBP with SUMO1\"", "Reactome:R-HSA-3968362 \"SUMOylation of PIAS4 with SUMO1\"", "Reactome:R-HSA-3968414 \"UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1\"", "Reactome:R-HSA-4085296 \"SUMOylation of NCOA1 with SUMO1\"", "Reactome:R-HSA-4085318 \"SUMOylation of NCOA2 with SUMO1\"", "Reactome:R-HSA-4085331 \"PIAS2-1 SUMOylates PARK7 with SUMO1\"", "Reactome:R-HSA-4085347 \"PIAS1 SUMOylates SAFB with SUMO1\"", "Reactome:R-HSA-4085350 \"SUMOylation of UBE2I with SUMO1\"", "Reactome:R-HSA-4085372 \"PIAS1 SUMOylates SAFB with SUMO2,3\"", "Reactome:R-HSA-4085992 \"SUMOylation of DAXX with SUMO1\"", "Reactome:R-HSA-4085994 \"TOPORS SUMOylates SIN3A with SUMO1\"", "Reactome:R-HSA-4086036 \"PIAS1,3 SUMOylate NRIP1 with SUMO1\"", "Reactome:R-HSA-4086059 \"SUMOylation of NPM1 with SUMO2,3\"", "Reactome:R-HSA-4086083 \"SUMOylation of ING2 with SUMO1\"", "Reactome:R-HSA-4086088 \"SUMOylation of NPM1 with SUMO1\"", "Reactome:R-HSA-4090281 \"PIAS1,2-1 SUMOylate HIC1 with SUMO1\"", "Reactome:R-HSA-4090284 \"SUMOylation of HIPK2 with SUMO1\"", "Reactome:R-HSA-4090288 \"PIAS1,3 SUMOylate MBD1 with SUMO1\"", "Reactome:R-HSA-4090390 \"PIAS1,2-1 SUMOylates AR with SUMO1\"", "Reactome:R-HSA-4090408 \"PIAS1,3 SUMOylate ESR1 with SUMO1\"", "Reactome:R-HSA-4341016 \"PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1\"", "Reactome:R-HSA-4341025 \"SUMOylation of NR3C1 (GR) with SUMO1\"", "Reactome:R-HSA-4341048 \"SUMOylation of RXRA with SUMO1\"", "Reactome:R-HSA-4341070 \"PIAS4 SUMOylates PPARA with SUMO1\"", "Reactome:R-HSA-4341072 \"SUMOylation of RARA with SUMO2\"", "Reactome:R-HSA-4341073 \"PIAS3 SUMOylates PGR with SUMO1\"", "Reactome:R-HSA-4546385 \"PIAS1,3 SUMOylates NR5A1 with SUMO2\"", "Reactome:R-HSA-4546386 \"PIAS1,3 SUMOylates NR5A1 with SUMO1\"", "Reactome:R-HSA-4546387 \"PIAS4 SUMOylates VDR with SUMO2\"", "Reactome:R-HSA-4551604 \"PIAS4 SUMOylates PARP1 with SUMO1\"", "Reactome:R-HSA-4551616 \"SUMOylation of RPA1 (RPA70) with SUMO2,3\"", "Reactome:R-HSA-4551648 \"SUMOylation of TDG with SUMO1\"", "Reactome:R-HSA-4551649 \"RANBP2 SUMOylates RANBP2 with SUMO1\"", "Reactome:R-HSA-4551655 \"CBX4 SUMOylates BMI1 in PRC1 with SUMO1\"", "Reactome:R-HSA-4551661 \"PIAS4 SUMOylates RNF168 with SUMO1\"", "Reactome:R-HSA-4551679 \"RANBP2 SUMOylates RANBP2 with SUMO2\"", "Reactome:R-HSA-4551683 \"SUMOylation of TOPORS with SUMO1\"", "Reactome:R-HSA-4551721 \"PIAS4 SUMOylates VHL with SUMO1\"", "Reactome:R-HSA-4551724 \"PIAS4 SUMOylates HERC2 with SUMO1\"", "Reactome:R-HSA-4551727 \"CBX4 SUMOylates CBX4 in PRC1 with SUMO1\"", "Reactome:R-HSA-4551738 \"SUMOylation of TDG with SUMO2,3\"", "Reactome:R-HSA-4551768 \"PIAS4 SUMOylates PARP1 with SUMO2,3\"", "Reactome:R-HSA-4568846 \"CDKN2A (p14-ARF) SUMOylates WRN with SUMO1\"", "Reactome:R-HSA-4568848 \"PIAS1,2-1 SUMOylates XRCC4 with SUMO1\"", "Reactome:R-HSA-4568863 \"SUMOylation of RAD52 with SUMO1\"", "Reactome:R-HSA-4568914 \"SUMOylation of BLM with SUMO2,3\"", "Reactome:R-HSA-4570463 \"CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3\"", "Reactome:R-HSA-4570467 \"SUMOylation of NOP58 with SUMO1\"", "Reactome:R-HSA-4570485 \"SUMOylation of Histone H4 with SUMO3\"", "Reactome:R-HSA-4570489 \"SUMOylation of NOP58 with SUMO2\"", "Reactome:R-HSA-4570493 \"RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1\"", "Reactome:R-HSA-4570496 \"SUMOylation of Histone H4 with SUMO1\"", "Reactome:R-HSA-4570499 \"CBX4 (Pc2) SUMOylates HNRNPK with SUMO2\"", "Reactome:R-HSA-4570528 \"SUMOylation of XPC with SUMO1\"", "Reactome:R-HSA-4570553 \"SUMOylation of MDC1 with SUMO2,3\"", "Reactome:R-HSA-4570554 \"SUMOylation of MDC1 with SUMO1\"", "Reactome:R-HSA-4615839 \"PIAS1 SUMOylates SATB1 with SUMO2,3\"", "Reactome:R-HSA-4615872 \"RANBP2 SUMOylates HDAC4 with SUMO1\"", "Reactome:R-HSA-4615873 \"PIAS2-2 SUMOylates SUZ12 with SUMO1\"", "Reactome:R-HSA-4615889 \"SUMOylation of HDAC1 with SUMO1\"", "Reactome:R-HSA-4615900 \"PIAS1 SUMOylates SATB2 with SUMO3\"", "Reactome:R-HSA-4615905 \"PIAS1 SUMOylates SATB1 with SUMO1\"", "Reactome:R-HSA-4615910 \"SUMOylation of PCNA with SUMO1\"", "Reactome:R-HSA-4615933 \"SUMOylation of CBX5 with SUMO1\"", "Reactome:R-HSA-4615987 \"RANBP2 SUMOylates HDAC4 with SUMO2,3\"", "Reactome:R-HSA-4616015 \"SUMOylation of HDAC2 with SUMO1\"", "Reactome:R-HSA-4641342 \"SUMOylation of TOP2A with SUMO1\"", "Reactome:R-HSA-4641345 \"SUMOylation of TOP2B with SUMO1\"", "Reactome:R-HSA-4641350 \"PIAS4 SUMOylates TOP2A with SUMO2,3\"", "Reactome:R-HSA-4641362 \"SUMOylation of TOP1 with SUMO1\"", "Reactome:R-HSA-4655355 \"RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)\"", "Reactome:R-HSA-4655374 \"SUMOylation of DNMT3B with SUMO1\"", "Reactome:R-HSA-4655431 \"SUMOyation of DNMT1 with SUMO1\"", "Reactome:R-HSA-4655440 \"CBX4 (Pc2) SUMOylates DNMT3A with SUMO1\"", "Reactome:R-HSA-4656914 \"SUMOylation of NFKBIA with SUMO1\"", "Reactome:R-HSA-4717461 \"PIAS1,2-2 SUMOylate PPARG with SUMO1\"", "Reactome:R-HSA-4717521 \"PIAS1 SUMOylates NR2C1 (TR2)\"", "Reactome:R-HSA-4719413 \"PIAS2,3,4 SUMOylate RORA with SUMO2\"", "Reactome:R-HSA-4719423 \"PIAS2-2 SUMOylates THRA with SUMO3\"", "Reactome:R-HSA-4719424 \"PIAS1 SUMOylates THRB with SUMO1\"", "Reactome:R-HSA-4719436 \"PIAS2,3,4 SUMOylate RORA with SUMO1\"", "Reactome:R-HSA-4719447 \"PIAS2-2 SUMOylates THRA with SUMO1\"", "Reactome:R-HSA-4719448 \"PIAS1 SUMOylates THRB with SUMO3\"", "Reactome:R-HSA-4720432 \"HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3\"", "Reactome:R-HSA-4720446 \"HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3\"", "Reactome:R-HSA-4755411 \"PIAS4 SUMOylates IKBKG with SUMO1\"", "Reactome:R-HSA-4755478 \"TOPORS SUMOylates IKBKE with SUMO1\"", "Reactome:R-HSA-4755479 \"SUMOylation of NFKB2 with SUMO1\"", "Reactome:R-HSA-4755494 \"PIAS1,2-1 SUMOylate NR5A2 with SUMO1\"", "Reactome:R-HSA-4755526 \"PIAS4 SUMOylates NR4A2 with SUMO2,3\"", "Reactome:R-HSA-4755536 \"PIAS3 SUMOylates RELA with SUMO3\"", "Reactome:R-HSA-5228508 \"RANBP2 SUMOylates PML with SUMO1\"", "Reactome:R-HSA-5228521 \"PIAS1,4 SUMOylate CASP8AP2 with SUMO1\"", "Reactome:R-HSA-5228523 \"RANBP2 SUMOylates MDM2 with SUMO1\"", "Reactome:R-HSA-5228525 \"RANBP2 SUMOylates TOP2A with SUMO1\"", "Reactome:R-HSA-5682607 \"PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs\"", "Reactome:R-HSA-5684052 \"PIAS4 SUMOylates MDC1\"", "Reactome:R-HSA-6790454 \"SUMOylation of XPC\"", "Reactome:R-HSA-6804468 \"PIAS1 SUMOylates SP3 with SUMO2\"", "Reactome:R-HSA-6804485 \"PIAS1 SUMOylates L3MBTL2 with SUMO2\"", "Reactome:R-HSA-8956365 \"ZBED1 (DREF) SUMOylates CHD3 with SUMO1\"", "Reactome:R-HSA-9920126 \"UBC9 SUMOylates NS5\"", "Reactome:R-HSA-9926476 \"UBE2I sumoylates MITF-M\"", "Reactome:R-HSA-9940458 \"GATAD2B is SUMOylated\"", "Reactome:R-HSA-9940470 \"GATAD2A is SUMOylated\"" ], "previous": [ "Reactome:R-HSA-2993769 \"Transfer of SUMO3 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2993780 \"Transfer of SUMO1 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2993790 \"Transfer of SUMO2 from E1 to UBE2I (UBC9)\"", "Reactome:R-HSA-2997616 \"PIAS1,4 SUMOylates BRCA1 with SUMO2,3\"", "Reactome:R-HSA-2997706 \"MDM2 SUMOylates TP53 with SUMO2,3\"", "Reactome:R-HSA-2997709 \"PIAS1,4 SUMOylates BRCA1 with SUMO1\"", "Reactome:R-HSA-2997723 \"PIAS4 SUMOylates TP53BP1 with SUMO1\"", "Reactome:R-HSA-3000348 \"RANBP2 SUMOylates SP100 with SUMO2\"", "Reactome:R-HSA-3000383 \"UBE2I, HDAC7 SUMOylate PML with SUMO1\"", "Reactome:R-HSA-3000399 \"RANBP2 SUMOylates SP100 with SUMO1\"", "Reactome:R-HSA-3000411 \"RANBP2 SUMOylates PML with SUMO2\"", "Reactome:R-HSA-3000433 \"SUMOylation of PML with SUMO3\"", "Reactome:R-HSA-3000434 \"PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1\"", "Reactome:R-HSA-3000449 \"UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2\"", "Reactome:R-HSA-3108203 \"PRC1 SUMOylates CTBP1 with SUMO2,3\"", "Reactome:R-HSA-3108209 \"PRC1 SUMOylates CTBP1 with SUMO1\"", "Reactome:R-HSA-3108212 \"SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1\"", "Reactome:R-HSA-3232162 \"PIAS3 SUMOylates MITF with SUMO1\"", "Reactome:R-HSA-3234081 \"SUMOylation of TFAP2A with SUMO1\"", "Reactome:R-HSA-3234084 \"SUMOylation of TFAP2B with SUMO1\"", "Reactome:R-HSA-3234094 \"SUMOylation of TFAP2C with SUMO1\"", "Reactome:R-HSA-3247493 \"PIAS1 SUMOylates SP3 with SUMO1\"", "Reactome:R-HSA-3296126 \"CBX4, UHRF2 SUMOylate ZNF131 with SUMO1\"", "Reactome:R-HSA-3465545 \"PIAS1,3,4 SUMOylate MTA1 with SUMO2,3\"", "Reactome:R-HSA-3782535 \"TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1\"", "Reactome:R-HSA-3899291 \"SUMOylation of EP300 with SUMO1\"", "Reactome:R-HSA-3900047 \"SUMOylation of DDX17 with SUMO1\"", "Reactome:R-HSA-3900070 \"SUMOylation of MKL1 with SUMO1\"", "Reactome:R-HSA-3900177 \"SUMOylation of DDX5 with SUMO1\"", "Reactome:R-HSA-3900194 \"PIAS1 SUMOylates DDX5 with SUMO2\"", "Reactome:R-HSA-3903017 \"SUMOylation of PPARGC1A with SUMO1\"", "Reactome:R-HSA-3927824 \"PRC1 SUMOylates CASP8AP2 with SUMO1\"", "Reactome:R-HSA-3927886 \"SUMOylation of NCOR2 with SUMO1\"", "Reactome:R-HSA-3927959 \"SUMOylation of CREBBP with SUMO1\"", "Reactome:R-HSA-3968362 \"SUMOylation of PIAS4 with SUMO1\"", "Reactome:R-HSA-3968414 \"UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1\"", "Reactome:R-HSA-4085296 \"SUMOylation of NCOA1 with SUMO1\"", "Reactome:R-HSA-4085318 \"SUMOylation of NCOA2 with SUMO1\"", "Reactome:R-HSA-4085331 \"PIAS2-1 SUMOylates PARK7 with SUMO1\"", "Reactome:R-HSA-4085347 \"PIAS1 SUMOylates SAFB with SUMO1\"", "Reactome:R-HSA-4085350 \"SUMOylation of UBE2I with SUMO1\"", "Reactome:R-HSA-4085372 \"PIAS1 SUMOylates SAFB with SUMO2,3\"", "Reactome:R-HSA-4085992 \"SUMOylation of DAXX with SUMO1\"", "Reactome:R-HSA-4085994 \"TOPORS SUMOylates SIN3A with SUMO1\"", "Reactome:R-HSA-4086036 \"PIAS1,3 SUMOylate NRIP1 with SUMO1\"", "Reactome:R-HSA-4086059 \"SUMOylation of NPM1 with SUMO2,3\"", "Reactome:R-HSA-4086083 \"SUMOylation of ING2 with SUMO1\"", "Reactome:R-HSA-4086088 \"SUMOylation of NPM1 with SUMO1\"", "Reactome:R-HSA-4090281 \"PIAS1,2-1 SUMOylate HIC1 with SUMO1\"", "Reactome:R-HSA-4090284 \"SUMOylation of HIPK2 with SUMO1\"", "Reactome:R-HSA-4090288 \"PIAS1,3 SUMOylate MBD1 with SUMO1\"", "Reactome:R-HSA-4090390 \"PIAS1,2-1 SUMOylates AR with SUMO1\"", "Reactome:R-HSA-4090408 \"PIAS1,3 SUMOylate ESR1 with SUMO1\"", "Reactome:R-HSA-4341016 \"PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1\"", "Reactome:R-HSA-4341025 \"SUMOylation of NR3C1 (GR) with SUMO1\"", "Reactome:R-HSA-4341048 \"SUMOylation of RXRA with SUMO1\"", "Reactome:R-HSA-4341070 \"PIAS4 SUMOylates PPARA with SUMO1\"", "Reactome:R-HSA-4341072 \"SUMOylation of RARA with SUMO2\"", "Reactome:R-HSA-4341073 \"PIAS3 SUMOylates PGR with SUMO1\"", "Reactome:R-HSA-4546385 \"PIAS1,3 SUMOylates NR5A1 with SUMO2\"", "Reactome:R-HSA-4546386 \"PIAS1,3 SUMOylates NR5A1 with SUMO1\"", "Reactome:R-HSA-4546387 \"PIAS4 SUMOylates VDR with SUMO2\"", "Reactome:R-HSA-4551604 \"PIAS4 SUMOylates PARP1 with SUMO1\"", "Reactome:R-HSA-4551616 \"SUMOylation of RPA1 (RPA70) with SUMO2,3\"", "Reactome:R-HSA-4551648 \"SUMOylation of TDG with SUMO1\"", "Reactome:R-HSA-4551649 \"RANBP2 SUMOylates RANBP2 with SUMO1\"", "Reactome:R-HSA-4551655 \"CBX4 SUMOylates BMI1 in PRC1 with SUMO1\"", "Reactome:R-HSA-4551661 \"PIAS4 SUMOylates RNF168 with SUMO1\"", "Reactome:R-HSA-4551679 \"RANBP2 SUMOylates RANBP2 with SUMO2\"", "Reactome:R-HSA-4551683 \"SUMOylation of TOPORS with SUMO1\"", "Reactome:R-HSA-4551721 \"PIAS4 SUMOylates VHL with SUMO1\"", "Reactome:R-HSA-4551724 \"PIAS4 SUMOylates HERC2 with SUMO1\"", "Reactome:R-HSA-4551727 \"CBX4 SUMOylates CBX4 in PRC1 with SUMO1\"", "Reactome:R-HSA-4551738 \"SUMOylation of TDG with SUMO2,3\"", "Reactome:R-HSA-4551768 \"PIAS4 SUMOylates PARP1 with SUMO2,3\"", "Reactome:R-HSA-4568846 \"CDKN2A (p14-ARF) SUMOylates WRN with SUMO1\"", "Reactome:R-HSA-4568848 \"PIAS1,2-1 SUMOylates XRCC4 with SUMO1\"", "Reactome:R-HSA-4568863 \"SUMOylation of RAD52 with SUMO1\"", "Reactome:R-HSA-4568914 \"SUMOylation of BLM with SUMO2,3\"", "Reactome:R-HSA-4570463 \"CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3\"", "Reactome:R-HSA-4570467 \"SUMOylation of NOP58 with SUMO1\"", "Reactome:R-HSA-4570485 \"SUMOylation of Histone H4 with SUMO3\"", "Reactome:R-HSA-4570489 \"SUMOylation of NOP58 with SUMO2\"", "Reactome:R-HSA-4570493 \"RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1\"", "Reactome:R-HSA-4570496 \"SUMOylation of Histone H4 with SUMO1\"", "Reactome:R-HSA-4570499 \"CBX4 (Pc2) SUMOylates HNRNPK with SUMO2\"", "Reactome:R-HSA-4570528 \"SUMOylation of XPC with SUMO1\"", "Reactome:R-HSA-4570553 \"SUMOylation of MDC1 with SUMO2,3\"", "Reactome:R-HSA-4570554 \"SUMOylation of MDC1 with SUMO1\"", "Reactome:R-HSA-4615839 \"PIAS1 SUMOylates SATB1 with SUMO2,3\"", "Reactome:R-HSA-4615872 \"RANBP2 SUMOylates HDAC4 with SUMO1\"", "Reactome:R-HSA-4615873 \"PIAS2-2 SUMOylates SUZ12 with SUMO1\"", "Reactome:R-HSA-4615889 \"SUMOylation of HDAC1 with SUMO1\"", "Reactome:R-HSA-4615900 \"PIAS1 SUMOylates SATB2 with SUMO3\"", "Reactome:R-HSA-4615905 \"PIAS1 SUMOylates SATB1 with SUMO1\"", "Reactome:R-HSA-4615910 \"SUMOylation of PCNA with SUMO1\"", "Reactome:R-HSA-4615933 \"SUMOylation of CBX5 with SUMO1\"", "Reactome:R-HSA-4615987 \"RANBP2 SUMOylates HDAC4 with SUMO2,3\"", "Reactome:R-HSA-4616015 \"SUMOylation of HDAC2 with SUMO1\"", "Reactome:R-HSA-4641342 \"SUMOylation of TOP2A with SUMO1\"", "Reactome:R-HSA-4641345 \"SUMOylation of TOP2B with SUMO1\"", "Reactome:R-HSA-4641350 \"PIAS4 SUMOylates TOP2A with SUMO2,3\"", "Reactome:R-HSA-4641362 \"SUMOylation of TOP1 with SUMO1\"", "Reactome:R-HSA-4655355 \"RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)\"", "Reactome:R-HSA-4655374 \"SUMOylation of DNMT3B with SUMO1\"", "Reactome:R-HSA-4655431 \"SUMOyation of DNMT1 with SUMO1\"", "Reactome:R-HSA-4655440 \"CBX4 (Pc2) SUMOylates DNMT3A with SUMO1\"", "Reactome:R-HSA-4656914 \"SUMOylation of NFKBIA with SUMO1\"", "Reactome:R-HSA-4717461 \"PIAS1,2-2 SUMOylate PPARG with SUMO1\"", "Reactome:R-HSA-4717521 \"PIAS1 SUMOylates NR2C1 (TR2)\"", "Reactome:R-HSA-4719413 \"PIAS2,3,4 SUMOylate RORA with SUMO2\"", "Reactome:R-HSA-4719423 \"PIAS2-2 SUMOylates THRA with SUMO3\"", "Reactome:R-HSA-4719424 \"PIAS1 SUMOylates THRB with SUMO1\"", "Reactome:R-HSA-4719436 \"PIAS2,3,4 SUMOylate RORA with SUMO1\"", "Reactome:R-HSA-4719447 \"PIAS2-2 SUMOylates THRA with SUMO1\"", "Reactome:R-HSA-4719448 \"PIAS1 SUMOylates THRB with SUMO3\"", "Reactome:R-HSA-4720432 \"HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3\"", "Reactome:R-HSA-4720446 \"HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3\"", "Reactome:R-HSA-4755411 \"PIAS4 SUMOylates IKBKG with SUMO1\"", "Reactome:R-HSA-4755478 \"TOPORS SUMOylates IKBKE with SUMO1\"", "Reactome:R-HSA-4755479 \"SUMOylation of NFKB2 with SUMO1\"", "Reactome:R-HSA-4755494 \"PIAS1,2-1 SUMOylate NR5A2 with SUMO1\"", "Reactome:R-HSA-4755526 \"PIAS4 SUMOylates NR4A2 with SUMO2,3\"", "Reactome:R-HSA-4755536 \"PIAS3 SUMOylates RELA with SUMO3\"", "Reactome:R-HSA-5228508 \"RANBP2 SUMOylates PML with SUMO1\"", "Reactome:R-HSA-5228521 \"PIAS1,4 SUMOylate CASP8AP2 with SUMO1\"", "Reactome:R-HSA-5228523 \"RANBP2 SUMOylates MDM2 with SUMO1\"", "Reactome:R-HSA-5228525 \"RANBP2 SUMOylates TOP2A with SUMO1\"", "Reactome:R-HSA-5682607 \"PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs\"", "Reactome:R-HSA-5684052 \"PIAS4 SUMOylates MDC1\"", "Reactome:R-HSA-6790454 \"SUMOylation of XPC\"", "Reactome:R-HSA-6804468 \"PIAS1 SUMOylates SP3 with SUMO2\"", "Reactome:R-HSA-6804485 \"PIAS1 SUMOylates L3MBTL2 with SUMO2\"", "Reactome:R-HSA-8956365 \"ZBED1 (DREF) SUMOylates CHD3 with SUMO1\"", "Reactome:R-HSA-9920126 \"UBC9 SUMOylates NS5\"", "Reactome:R-HSA-9926476 \"UBE2I sumoylates MITF-M\"" ] } } }, { "id": "GO:0022842", "name": "narrow pore channel activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-1855161 \"I(1,3,4,5,6)P5 transports from the nucleus to the cytosol\"", "Reactome:R-HSA-1855168 \"I(1,3,4,5)P4 transports from the cytosol to the nucleus\"", "Reactome:R-HSA-1855173 \"5-PP-IP4 transports from the nucleus to the cytosol\"", "Reactome:R-HSA-1855188 \"IP6 transports from the cytosol to the nucleus\"", "Reactome:R-HSA-1855190 \"I(1,4,5)P3 transports from the cytosol to the nucleus\"", "Reactome:R-HSA-1855201 \"I(1,3,4,6)P4 transports from the cytosol to the nucleus\"", "Reactome:R-HSA-1855203 \"5-PP-IP5 transports from the nucleus to the cytosol\"", "Reactome:R-HSA-1855212 \"1/3-PP-IP5 transports from the cytosol to the nucleus\"", "Reactome:R-HSA-1855220 \"(PP)2-IP4 transports from the nucleus to the cytosol\"" ], "previous": "N/A" } } }, { "id": "GO:0030343", "name": "vitamin D 25-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.14.24", "MetaCyc:RXN-9829", "Reactome:R-HSA-209845 \"CYP2R1 25-hydroxylates VD3 to 25(OH)D\"", "Reactome:R-HSA-5602147 \"Defective CYP2R1 does not 25-hydroxylate vitamin D\"", "RHEA:32903" ], "previous": [ "MetaCyc:RXN-9829", "Reactome:R-HSA-209845 \"CYP2R1 25-hydroxylates VD3 to 25(OH)D\"", "Reactome:R-HSA-5602147 \"Defective CYP2R1 does not 25-hydroxylate vitamin D\"", "RHEA:32903" ] } } }, { "id": "GO:0033721", "name": "aldehyde dehydrogenase (NADP+) activity", "changes": { "xrefs": { "current": [ "EC:1.2.1.4", "MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN", "RHEA:11888", "RHEA:27918", "RHEA:28410", "RHEA:30803", "RHEA:34215", "RHEA:47928", "RHEA:59428", "RHEA:59904", "RHEA:59908", "RHEA:59912", "RHEA:59916", "RHEA:60680", "RHEA:60684", "RHEA:60692", "RHEA:60716", "RHEA:60720", "RHEA:60724", "RHEA:60728", "RHEA:60732", "RHEA:60736", "RHEA:60740", "RHEA:62248", "RHEA:68412", "RHEA:72535", "RHEA:72539", "RHEA:76651", "RHEA:76659", "RHEA:76663", "RHEA:76671", "RHEA:76967", "RHEA:80815", "RHEA:80819", "RHEA:80823", "RHEA:81423" ], "previous": [ "EC:1.2.1.4", "MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN", "RHEA:11888", "RHEA:28410", "RHEA:30803", "RHEA:34215", "RHEA:47928", "RHEA:60680", "RHEA:60684", "RHEA:60716", "RHEA:60728", "RHEA:60732", "RHEA:60736", "RHEA:60740", "RHEA:62248", "RHEA:68412", "RHEA:72535", "RHEA:72539", "RHEA:76671", "RHEA:80823", "RHEA:81423" ] } } }, { "id": "GO:0033797", "name": "selenate reductase activity", "changes": { "xrefs": { "current": [ "EC:1.97.1.9", "KEGG_REACTION:R07229", "MetaCyc:RXN0-2101", "RHEA:14029", "RHEA:34939", "RHEA:51636", "RHEA:80603", "UM-BBD_reactionID:r0828" ], "previous": [ "EC:1.97.1.9", "KEGG_REACTION:R07229", "MetaCyc:RXN0-2101", "RHEA:14029", "RHEA:51636", "RHEA:80603", "UM-BBD_reactionID:r0828" ] } } }, { "id": "GO:0036397", "name": "formate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.17.5.3", "KEGG_REACTION:R09494", "MetaCyc:FORMATEDEHYDROG-RXN", "RHEA:29063", "RHEA:29067", "RHEA:29071", "RHEA:48592" ], "previous": [ "EC:1.17.5.3", "KEGG_REACTION:R09494", "MetaCyc:FORMATEDEHYDROG-RXN", "RHEA:29063", "RHEA:29071", "RHEA:48592" ] } } }, { "id": "GO:0036441", "name": "2-dehydropantolactone reductase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.358", "KEGG_REACTION:R03155", "RHEA:18981" ], "previous": [ "KEGG_REACTION:R03155", "RHEA:18981" ] } } }, { "id": "GO:0038024", "name": "cargo receptor activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-203716 \"eNOS:Caveolin-1 complex binds to Nostrin\"", "Reactome:R-HSA-2160915 \"Receptor-mediated uptake of HA\"", "Reactome:R-HSA-2248891 \"M6PR transports activated ARSA to the lysosome\"", "Reactome:R-HSA-3000103 \"CUBN:AMN binds CBLIF:RCbl\"", "Reactome:R-HSA-3000112 \"CD320-mediated TCN2:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-3000122 \"CD320 binds extracellular TCN2:RCbl\"", "Reactome:R-HSA-3000137 \"CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-350168 \"LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D\"", "Reactome:R-HSA-350186 \"CUBN binds GC:25(OH)D\"", "Reactome:R-HSA-9662747 \"iRHOM2 transports ADAM17 from ER to the Golgi-network\"", "Reactome:R-HSA-9662818 \"iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane\"", "Reactome:R-HSA-9759202 \"LRP2-mediated TCN2:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-9759209 \"LRP2 binds extracellular TCN2:RCbl\"" ], "previous": [ "Reactome:R-HSA-203716 \"eNOS:Caveolin-1 complex binds to Nostrin\"", "Reactome:R-HSA-2160915 \"Receptor-mediated uptake of HA\"", "Reactome:R-HSA-3000103 \"CUBN:AMN binds CBLIF:RCbl\"", "Reactome:R-HSA-3000112 \"CD320-mediated TCN2:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-3000122 \"CD320 binds extracellular TCN2:RCbl\"", "Reactome:R-HSA-3000137 \"CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-350168 \"LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D\"", "Reactome:R-HSA-350186 \"CUBN binds GC:25(OH)D\"", "Reactome:R-HSA-9759202 \"LRP2-mediated TCN2:RCbl uptake and delivery to lysosome\"", "Reactome:R-HSA-9759209 \"LRP2 binds extracellular TCN2:RCbl\"" ] } } }, { "id": "GO:0042054", "name": "histone methyltransferase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-5205861 \"COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)\"", "Reactome:R-HSA-5216234 \"PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)\"", "Reactome:R-HSA-9822583 \"METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)\"", "RHEA:10024", "RHEA:60312", "RHEA:67112", "RHEA:67808" ], "previous": [ "Reactome:R-HSA-5205861 \"COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)\"", "Reactome:R-HSA-5216234 \"PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)\"", "Reactome:R-HSA-9822583 \"METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)\"", "RHEA:10024" ] } } }, { "id": "GO:0042626", "name": "ATPase-coupled transmembrane transporter activity", "changes": { "xrefs": { "current": [ "EC:7.2.2.-", "Reactome:R-HSA-1222523 \"SodB gets secreted\"", "Reactome:R-HSA-1454916 \"The ABCC family mediates organic anion transport\"", "Reactome:R-HSA-1467457 \"ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region\"", "Reactome:R-HSA-2161506 \"abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate\"", "Reactome:R-HSA-2161538 \"abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate\"", "Reactome:R-HSA-390393 \"Peroxisomal uptake of very long-chain fatty acyl CoA\"", "Reactome:R-HSA-5690340 \"Defective ABCC6 does not transport organic anion from cytosol to extracellular region\"", "Reactome:R-HSA-9033499 \"PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol\"", "Reactome:R-HSA-9033505 \"PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12\"", "Reactome:R-HSA-9659680 \"ABCB1 transports xenobiotics out of the cell\"", "Reactome:R-HSA-9750546 \"ABCC4 transports TPMP substrates from cytosol to extracellular region\"", "Reactome:R-HSA-9750617 \"ABCC5 transports TPMP substrates from cytosol to extracellular region\"", "Reactome:R-HSA-9753278 \"ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3\"", "Reactome:R-HSA-9753283 \"ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3\"", "Reactome:R-HSA-9753284 \"ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region\"", "Reactome:R-HSA-9759454 \"ABCB1 transports PREDN,PREDL out of kidney cells\"", "Reactome:R-HSA-9759461 \"ABCB1 transports PREDN,PREDL out of hepatic cells\"", "Reactome:R-HSA-9794120 \"ABCG2 transports Cipro from intestinal cell to extracellular space\"", "Reactome:R-HSA-9794572 \"ABCG2 transports Cipro from hepatic cell to extracellular space\"" ], "previous": [ "EC:7.2.2.-", "Reactome:R-HSA-1454916 \"The ABCC family mediates organic anion transport\"", "Reactome:R-HSA-1467457 \"ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region\"", "Reactome:R-HSA-2161506 \"abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate\"", "Reactome:R-HSA-2161538 \"abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate\"", "Reactome:R-HSA-390393 \"Peroxisomal uptake of very long-chain fatty acyl CoA\"", "Reactome:R-HSA-5690340 \"Defective ABCC6 does not transport organic anion from cytosol to extracellular region\"", "Reactome:R-HSA-9033499 \"PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol\"", "Reactome:R-HSA-9033505 \"PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12\"", "Reactome:R-HSA-9659680 \"ABCB1 transports xenobiotics out of the cell\"", "Reactome:R-HSA-9750546 \"ABCC4 transports TPMP substrates from cytosol to extracellular region\"", "Reactome:R-HSA-9750617 \"ABCC5 transports TPMP substrates from cytosol to extracellular region\"", "Reactome:R-HSA-9753278 \"ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3\"", "Reactome:R-HSA-9753283 \"ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3\"", "Reactome:R-HSA-9753284 \"ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region\"", "Reactome:R-HSA-9759454 \"ABCB1 transports PREDN,PREDL out of kidney cells\"", "Reactome:R-HSA-9759461 \"ABCB1 transports PREDN,PREDL out of hepatic cells\"", "Reactome:R-HSA-9794120 \"ABCG2 transports Cipro from intestinal cell to extracellular space\"", "Reactome:R-HSA-9794572 \"ABCG2 transports Cipro from hepatic cell to extracellular space\"" ] } } }, { "id": "GO:0043712", "name": "(R)-2-hydroxy-4-methylpentanoate CoA-transferase activity", "changes": { "xrefs": { "current": [ "EC:2.8.3.24", "RHEA:49440" ], "previous": "N/A" } } }, { "id": "GO:0043770", "name": "demethylmenaquinone methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.163", "MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN", "MetaCyc:RXN-11046", "MetaCyc:RXN-9191", "RHEA:26466", "RHEA:30063", "RHEA:33255", "RHEA:42640", "RHEA:44776", "RHEA:44780", "RHEA:44784", "RHEA:44788", "RHEA:44792", "RHEA:44796" ], "previous": [ "EC:2.1.1.163", "MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN", "MetaCyc:RXN-11046", "MetaCyc:RXN-9191", "RHEA:26466", "RHEA:42640" ] } } }, { "id": "GO:0044104", "name": "2,5-dioxovalerate dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-8775", "RHEA:47152" ], "previous": "N/A" } } }, { "id": "GO:0044183", "name": "protein folding chaperone", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-9018785 \"RHOBTB2 binds GTP\"", "Reactome:R-HSA-9683772 \"Trimmed spike protein binds to calnexin\"", "Reactome:R-HSA-9694337 \"Trimmed spike protein binds to calnexin\"", "Reactome:R-HSA-9855212 \"SDHA binds to SDHB\"", "Reactome:R-HSA-9865893 \"MT-CYB is translated\"", "Reactome:R-HSA-9866253 \"apo-UQCRFS1 binds LYRM7\"" ], "previous": [ "Reactome:R-HSA-9018785 \"RHOBTB2 binds GTP\"", "Reactome:R-HSA-9855212 \"SDHA binds to SDHB\"", "Reactome:R-HSA-9865893 \"MT-CYB is translated\"", "Reactome:R-HSA-9866253 \"apo-UQCRFS1 binds LYRM7\"" ] } } }, { "id": "GO:0044688", "name": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.4.56", "MetaCyc:RXN-12356", "MetaCyc:RXN-12357 {xref=\"skos:narrowMatch\"}", "RHEA:35799", "RHEA:35803" ], "previous": "N/A" } } }, { "id": "GO:0047081", "name": "3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity", "changes": { "xrefs": { "current": [ "EC:1.14.13.242", "MetaCyc:1.14.12.4-RXN", "RHEA:10860", "RHEA:10864" ], "previous": [ "EC:1.14.13.242", "MetaCyc:1.14.12.4-RXN", "RHEA:10864" ] } } }, { "id": "GO:0047184", "name": "1-acylglycerophosphocholine O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.23", "MetaCyc:2.3.1.23-RXN", "Reactome:R-HSA-1482794 \"CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)\"", "RHEA:12937", "RHEA:33359", "RHEA:35983", "RHEA:35987", "RHEA:35991", "RHEA:35995", "RHEA:35999", "RHEA:37383", "RHEA:37387", "RHEA:37391", "RHEA:37395", "RHEA:37475", "RHEA:37479", "RHEA:37483", "RHEA:37487", "RHEA:37511", "RHEA:37515", "RHEA:37519", "RHEA:37527", "RHEA:37559", "RHEA:37563", "RHEA:37655", "RHEA:37703", "RHEA:37707", "RHEA:37803", "RHEA:37843", "RHEA:37855", "RHEA:37859", "RHEA:37863", "RHEA:37867" ], "previous": [ "EC:2.3.1.23", "MetaCyc:2.3.1.23-RXN", "Reactome:R-HSA-1482794 \"CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)\"", "RHEA:12937", "RHEA:33359", "RHEA:35987", "RHEA:37475", "RHEA:37515", "RHEA:37559", "RHEA:37563", "RHEA:37703", "RHEA:37707", "RHEA:37803", "RHEA:37855", "RHEA:37859", "RHEA:37863", "RHEA:37867" ] } } }, { "id": "GO:0047191", "name": "1-alkylglycerophosphocholine O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.63", "MetaCyc:2.3.1.63-RXN", "RHEA:23992", "RHEA:37715", "RHEA:37747", "RHEA:37783", "RHEA:37787", "RHEA:37811", "RHEA:37839" ], "previous": [ "EC:2.3.1.63", "MetaCyc:2.3.1.63-RXN", "RHEA:23992", "RHEA:37715", "RHEA:37783", "RHEA:37811", "RHEA:37839" ] } } }, { "id": "GO:0047290", "name": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.4.3.7", "KEGG_REACTION:R04635", "MetaCyc:2.4.99.7-RXN", "Reactome:R-HSA-981809 \"ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen\"", "RHEA:41968", "RHEA:48316", "RHEA:53896", "RHEA:56088", "RHEA:65280", "RHEA:65284", "RHEA:65288", "RHEA:77679" ], "previous": [ "EC:2.4.3.7", "KEGG_REACTION:R04635", "MetaCyc:2.4.99.7-RXN", "Reactome:R-HSA-981809 \"ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen\"", "RHEA:48316", "RHEA:53896", "RHEA:56088", "RHEA:65280", "RHEA:65284", "RHEA:65288" ] } } }, { "id": "GO:0047305", "name": "(R)-3-amino-2-methylpropionate:pyruvate transaminase activity", "changes": { "xrefs": { "current": [ "EC:2.6.1.40", "KEGG_REACTION:R02050", "MetaCyc:2.6.1.40-RXN", "Reactome:R-HSA-909780 \"(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine\"", "RHEA:18393" ], "previous": [ "EC:2.6.1.40", "KEGG_REACTION:R02050", "MetaCyc:2.6.1.40-RXN", "Reactome:R-HSA-909780 \"(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine\"", "RHEA:18393" ] } } }, { "id": "GO:0047372", "name": "monoacylglycerol lipase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.23", "MetaCyc:RXN-19280", "Reactome:R-HSA-1482543 \"2-MAG is hydrolyzed to fatty acid and glycerol by MGLL\"", "Reactome:R-HSA-163595 \"2-acylglycerol + H2O -> glycerol + fatty acid\"", "Reactome:R-HSA-192422 \"Digestion of triacylglycerols by extracellular PTL:colipase\"", "Reactome:R-HSA-192425 \"Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-192430 \"Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-192434 \"Digestion of diacylglycerols by extracellular PTL:colipase\"", "Reactome:R-HSA-192475 \"Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2\"", "Reactome:R-HSA-426032 \"DAG is metabolized by DAGL to 2-AG\"", "Reactome:R-HSA-426043 \"2-AG hydrolysis to arachidonate by MAGL\"", "Reactome:R-HSA-5694462 \"ABHD6,12 hydrolyse 3AG\"", "RHEA:15245", "RHEA:32875", "RHEA:34019", "RHEA:38363", "RHEA:38487", "RHEA:38491", "RHEA:39959", "RHEA:40607", "RHEA:44312", "RHEA:44316", "RHEA:44320", "RHEA:44688", "RHEA:44728", "RHEA:47072", "RHEA:58040", "RHEA:58076", "RHEA:58080", "RHEA:58084", "RHEA:58088", "RHEA:58092", "RHEA:58096", "RHEA:58100", "RHEA:78151" ], "previous": [ "EC:3.1.1.23", "MetaCyc:RXN-19280", "Reactome:R-HSA-1482543 \"2-MAG is hydrolyzed to fatty acid and glycerol by MGLL\"", "Reactome:R-HSA-163595 \"2-acylglycerol + H2O -> glycerol + fatty acid\"", "Reactome:R-HSA-192422 \"Digestion of triacylglycerols by extracellular PTL:colipase\"", "Reactome:R-HSA-192425 \"Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-192430 \"Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)\"", "Reactome:R-HSA-192434 \"Digestion of diacylglycerols by extracellular PTL:colipase\"", "Reactome:R-HSA-192475 \"Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2\"", "Reactome:R-HSA-426032 \"DAG is metabolized by DAGL to 2-AG\"", "Reactome:R-HSA-426043 \"2-AG hydrolysis to arachidonate by MAGL\"", "Reactome:R-HSA-5694462 \"ABHD6,12 hydrolyse 3AG\"", "RHEA:15245", "RHEA:34019", "RHEA:44688" ] } } }, { "id": "GO:0047429", "name": "nucleoside triphosphate diphosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.9", "MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN", "Reactome:R-HSA-9755030 \"ITPA dimer dephosphorylates RBV-TP to RBV-MP\"", "RHEA:23996", "RHEA:27762", "RHEA:44644", "RHEA:58732", "RHEA:58736", "RHEA:58740", "RHEA:58744" ], "previous": [ "EC:3.6.1.9", "MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN", "Reactome:R-HSA-9755030 \"ITPA dimer dephosphorylates RBV-TP to RBV-MP\"", "RHEA:23996", "RHEA:44644" ] } } }, { "id": "GO:0047620", "name": "acylglycerol kinase activity", "changes": { "xrefs": { "current": [ "EC:2.7.1.94", "MetaCyc:ACYLGLYCEROL-KINASE-RXN", "Reactome:R-HSA-5696074 \"AGK:Mg2+ phosphorylates MAG, DAG\"", "RHEA:19293", "RHEA:33747", "RHEA:39847", "RHEA:41079", "RHEA:43308", "RHEA:43316", "RHEA:43328", "RHEA:63328" ], "previous": [ "EC:2.7.1.94", "MetaCyc:ACYLGLYCEROL-KINASE-RXN", "Reactome:R-HSA-5696074 \"AGK:Mg2+ phosphorylates MAG, DAG\"", "RHEA:19293", "RHEA:33747", "RHEA:39847" ] } } }, { "id": "GO:0047645", "name": "alkan-1-ol dehydrogenase (acceptor) activity", "changes": { "xrefs": { "current": [ "EC:1.1.99.20", "MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN", "RHEA:14685", "RHEA:17085", "RHEA:27538", "RHEA:27542", "RHEA:33567", "RHEA:33571", "RHEA:48076", "RHEA:51148", "RHEA:76451", "RHEA:76455", "RHEA:76459", "RHEA:76463" ], "previous": [ "EC:1.1.99.20", "MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN", "RHEA:14685", "RHEA:17085", "RHEA:33567", "RHEA:33571", "RHEA:48076", "RHEA:51148", "RHEA:76451", "RHEA:76455", "RHEA:76459", "RHEA:76463" ] } } }, { "id": "GO:0047804", "name": "cysteine-S-conjugate beta-lyase activity", "changes": { "xrefs": { "current": [ "EC:4.4.1.13", "MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN", "MetaCyc:RXN-6763", "RHEA:13965", "RHEA:18121", "RHEA:22424", "RHEA:64740", "RHEA:64744", "RHEA:64748", "RHEA:64752", "RHEA:64756", "RHEA:64760" ], "previous": [ "EC:4.4.1.13", "MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN", "MetaCyc:RXN-6763", "RHEA:13965", "RHEA:18121", "RHEA:22424", "RHEA:64740", "RHEA:64744", "RHEA:64748", "RHEA:64752", "RHEA:64756" ] } } }, { "id": "GO:0047876", "name": "endoglycosylceramidase activity", "changes": { "xrefs": { "current": [ "EC:3.2.1.123", "MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN", "RHEA:22288", "RHEA:65540", "RHEA:65544", "RHEA:65548", "RHEA:65552", "RHEA:65556", "RHEA:77675" ], "previous": [ "EC:3.2.1.123", "MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN", "RHEA:22288", "RHEA:65540", "RHEA:65544", "RHEA:65548", "RHEA:65552", "RHEA:65556" ] } } }, { "id": "GO:0047961", "name": "glycine N-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.13", "MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-2534040 \"Unknown NAT N-acylates Gly in GNAT1\"", "Reactome:R-HSA-9971621 \"GLYAT transfers ISB to glycine\"", "RHEA:19869", "RHEA:49772", "RHEA:49780", "RHEA:49788", "RHEA:49792", "RHEA:51272", "RHEA:51364", "RHEA:51368", "RHEA:51372", "RHEA:58536", "RHEA:64240", "RHEA:64244", "RHEA:64248", "RHEA:64252", "RHEA:64256", "RHEA:64260" ], "previous": [ "EC:2.3.1.13", "MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-2534040 \"Unknown NAT N-acylates Gly in GNAT1\"", "RHEA:19869", "RHEA:49788", "RHEA:64244" ] } } }, { "id": "GO:0047962", "name": "glycine N-benzoyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.71", "KEGG_REACTION:R02452", "MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN", "Reactome:R-HSA-159566 \"benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A\"", "Reactome:R-HSA-159574 \"GLYAT-like proteins transfer glycine to ST-CoA to form SUA\"", "Reactome:R-HSA-9750001 \"GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid\"", "Reactome:R-HSA-9971063 \"GLYAT-like proteins transfer glycine to phenylacetyl-CoA\"", "Reactome:R-HSA-9972916 \"GLYAT-like proteins transfer glycine to aminobenzoyl-CoA\"", "RHEA:18493" ], "previous": [ "EC:2.3.1.71", "KEGG_REACTION:R02452", "MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN", "Reactome:R-HSA-159566 \"benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A\"", "Reactome:R-HSA-159574 \"GLYAT-like proteins transfer glycine to ST-CoA to form SUA\"", "Reactome:R-HSA-9750001 \"GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid\"", "RHEA:18493" ] } } }, { "id": "GO:0050018", "name": "amino-acid dehydrogenase [NAD(P)+] activity", "changes": { "xrefs": { "current": [ "EC:1.4.1.5", "MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN", "RHEA:10396", "RHEA:32959", "RHEA:37035", "RHEA:37259", "RHEA:47632", "RHEA:65196" ], "previous": [ "EC:1.4.1.5", "MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN", "RHEA:10396" ] } } }, { "id": "GO:0050136", "name": "NADH dehydrogenase (quinone) (non-electrogenic) activity", "changes": { "xrefs": { "current": [ "EC:1.6.5.9", "MetaCyc:1.6.99.5-RXN", "RHEA:46160", "RHEA:60660", "RHEA:61984", "RHEA:69695", "RHEA:74075", "RHEA:74079", "RHEA:83235", "RHEA:83243" ], "previous": [ "EC:1.6.5.9", "MetaCyc:1.6.99.5-RXN", "RHEA:46160", "RHEA:60660", "RHEA:61984", "RHEA:69695", "RHEA:74075", "RHEA:74079", "RHEA:83235" ] } } }, { "id": "GO:0050153", "name": "omega-hydroxydecanoate dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.66", "KEGG_REACTION:R03886", "MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN", "Reactome:R-HSA-9971258 \"ADH7 dehydrogenates 10-OH-DECA\"", "RHEA:20880" ], "previous": [ "EC:1.1.1.66", "KEGG_REACTION:R03886", "MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN", "RHEA:20880" ] } } }, { "id": "GO:0050207", "name": "plasmanylethanolamine desaturase activity", "changes": { "xrefs": { "current": [ "EC:1.14.19.77", "MetaCyc:RXN-17732", "RHEA:22956", "RHEA:61956", "RHEA:61960", "RHEA:61964", "RHEA:61968", "RHEA:61972" ], "previous": [ "EC:1.14.19.77", "MetaCyc:RXN-17732", "RHEA:22956", "RHEA:61960", "RHEA:61964", "RHEA:61968", "RHEA:61972" ] } } }, { "id": "GO:0050253", "name": "retinyl-palmitate esterase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN", "Reactome:R-HSA-2404133 \"A REH hydrolyses atREs to atROL and FAs\"", "Reactome:R-HSA-8848355 \"PNPLA4 hydrolyzes retinyl palmitate\"", "Reactome:R-HSA-975593 \"PNLIP:CLPS hydrolyses RPALM to atROL and PALM\"", "Reactome:R-HSA-975594 \"PLB1 hydrolyses RPALM to atROL\"", "RHEA:21508" ], "previous": [ "MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN", "Reactome:R-HSA-2404133 \"A REH hydrolses atREs to atROL and FAs\"", "Reactome:R-HSA-8848355 \"PNPLA4 hydrolyzes retinyl palmitate\"", "Reactome:R-HSA-975593 \"PNLIP:CLPS hydrolyses RPALM to atROL and PALM\"", "Reactome:R-HSA-975594 \"PLB1 hydrolyses RPALM to atROL\"", "RHEA:21508" ] } } }, { "id": "GO:0050291", "name": "sphingosine N-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.24", "MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-428185 \"Ceramide synthases transfer acyl-CoA onto sphingoid\"", "RHEA:23768", "RHEA:36687", "RHEA:36691", "RHEA:37111", "RHEA:37115", "RHEA:37123", "RHEA:45284", "RHEA:64044" ], "previous": [ "EC:2.3.1.24", "MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN", "Reactome:R-HSA-428185 \"Ceramide synthases transfer acyl-CoA onto sphingoid\"", "RHEA:23768", "RHEA:36687", "RHEA:36691", "RHEA:37115", "RHEA:37123", "RHEA:45284", "RHEA:64044" ] } } }, { "id": "GO:0052598", "name": "histamine oxidase activity", "changes": { "xrefs": { "current": [ "KEGG_REACTION:R02150", "MetaCyc:RXN-9600", "Reactome:R-HSA-5696131 \"AOC1 deaminates Hist\"", "Reactome:R-HSA-9970023 \"AOC1 dimer oxidizes MeHist\"", "RHEA:25625" ], "previous": [ "KEGG_REACTION:R02150", "MetaCyc:RXN-9600", "Reactome:R-HSA-5696131 \"AOC1 deaminates Hist\"", "RHEA:25625" ] } } }, { "id": "GO:0052664", "name": "nitroalkane oxidase activity", "changes": { "xrefs": { "current": [ "EC:1.7.3.1", "KEGG_REACTION:R00799", "KEGG_REACTION:R10389", "MetaCyc:NITROETHANE-OXIDASE-RXN", "MetaCyc:RXN-11045", "RHEA:20976", "RHEA:26490", "RHEA:50772" ], "previous": [ "EC:1.7.3.1", "KEGG_REACTION:R00799", "KEGG_REACTION:R10389", "MetaCyc:NITROETHANE-OXIDASE-RXN", "MetaCyc:RXN-11045", "RHEA:20976", "RHEA:26490" ] } } }, { "id": "GO:0052797", "name": "4-O-methyl-glucuronoyl methylesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.117", "RHEA:67452" ], "previous": "N/A" } } }, { "id": "GO:0052891", "name": "aliphatic (S)-hydroxynitrile lyase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-11731", "RHEA:56588", "RHEA:56592", "RHEA:77395", "RHEA:77399", "RHEA:77403", "RHEA:77407", "RHEA:77411", "RHEA:77415", "RHEA:77419", "RHEA:77423", "RHEA:77471", "RHEA:77479", "RHEA:77483", "RHEA:77487", "RHEA:77491", "RHEA:77523", "RHEA:77527", "RHEA:77531" ], "previous": [ "MetaCyc:RXN-11731", "RHEA:56588", "RHEA:56592" ] } } }, { "id": "GO:0062101", "name": "peptidyl-aspartic acid 3-dioxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RHEA:11508", "RHEA:54276", "RHEA:54280" ], "previous": [ "EC:1.14.11.16", "MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN", "Reactome:R-HSA-9631355 \"ASPH:Fe2+ hydroxylates an aspartate residue of F9\"", "RHEA:11508", "RHEA:54276" ] } } }, { "id": "GO:0062105", "name": "RNA 2'-O-methyltransferase activity", "changes": { "xrefs": { "current": [ "RHEA:24140", "RHEA:42724", "RHEA:42788", "RHEA:42924", "RHEA:43200", "RHEA:43204", "RHEA:47756", "RHEA:47768", "RHEA:47772", "RHEA:47776", "RHEA:48628", "RHEA:56884", "RHEA:58956", "RHEA:65380", "RHEA:73759" ], "previous": [ "RHEA:42724", "RHEA:48628", "RHEA:56884", "RHEA:58956", "RHEA:65380" ] } } }, { "id": "GO:0062154", "name": "N6-methyl-AMP deaminase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2161187 \"MAPDA hydrolyzes N6-methyl-AMP to IMP and methylamine\"", "Reactome:R-HSA-2161195 \"abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine\"", "Reactome:R-HSA-9731661 \"MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamine\"", "RHEA:16001" ], "previous": [ "Reactome:R-HSA-2161187 \"ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine\"", "Reactome:R-HSA-2161195 \"abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine\"", "Reactome:R-HSA-9731661 \"ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine\"", "RHEA:16001" ] } } }, { "id": "GO:0070290", "name": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "changes": { "xrefs": { "current": [ "EC:3.1.4.54", "MetaCyc:RXN-12116", "Reactome:R-HSA-2466831 \"A2PE hydrolyses to A2E\"", "RHEA:33159", "RHEA:45528", "RHEA:45532", "RHEA:45536", "RHEA:45540", "RHEA:45552", "RHEA:45556", "RHEA:45596", "RHEA:45608", "RHEA:45612", "RHEA:45616", "RHEA:45620", "RHEA:56544", "RHEA:56548" ], "previous": [ "EC:3.1.4.54", "MetaCyc:RXN-12116", "Reactome:R-HSA-2466831 \"A2PE hydrolyses to A2E\"", "RHEA:33159", "RHEA:45532", "RHEA:45536", "RHEA:45552", "RHEA:45556", "RHEA:45608", "RHEA:45612", "RHEA:45616", "RHEA:45620", "RHEA:56544", "RHEA:56548" ] } } }, { "id": "GO:0070675", "name": "hypoxanthine oxidase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-74247 \"XDH oxidizes hypoxanthine to form xanthine\"", "RHEA:68012" ], "previous": [ "Reactome:R-HSA-74247 \"XDH oxidizes hypoxanthine to form xanthine\"" ] } } }, { "id": "GO:0070818", "name": "protoporphyrinogen oxidase activity", "changes": { "xrefs": { "current": [ "RHEA:62000" ], "previous": "N/A" } } }, { "id": "GO:0070819", "name": "protoporphyrinogen oxidase activity, quinone as acceptor", "changes": { "xrefs": { "current": [ "EC:1.3.5.3", "RHEA:27409", "RHEA:63936", "RHEA:65032" ], "previous": "N/A" } } }, { "id": "GO:0080023", "name": "(2E)-enoyl-CoA hydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.119", "MetaCyc:RXN-7699", "RHEA:26526", "RHEA:39155", "RHEA:39159", "RHEA:39175", "RHEA:39187", "RHEA:39247", "RHEA:39259", "RHEA:39303", "RHEA:39315", "RHEA:39327", "RHEA:39343", "RHEA:39351", "RHEA:39363", "RHEA:39375", "RHEA:39387", "RHEA:39399", "RHEA:39411", "RHEA:39423", "RHEA:39439", "RHEA:39451", "RHEA:39463", "RHEA:39475", "RHEA:39487", "RHEA:39499", "RHEA:39511", "RHEA:39523", "RHEA:39535", "RHEA:39547", "RHEA:39559", "RHEA:39579", "RHEA:39591", "RHEA:39603", "RHEA:39615", "RHEA:39627", "RHEA:39639", "RHEA:39687", "RHEA:39699", "RHEA:44024", "RHEA:46720", "RHEA:67216", "RHEA:67228", "RHEA:72575", "RHEA:78643", "RHEA:78863", "RHEA:78867", "RHEA:78931" ], "previous": [ "EC:4.2.1.119", "MetaCyc:RXN-7699", "RHEA:26526", "RHEA:39303", "RHEA:39343", "RHEA:39351", "RHEA:39363", "RHEA:39375", "RHEA:39387", "RHEA:39399", "RHEA:39411", "RHEA:39423", "RHEA:39439", "RHEA:39475", "RHEA:39487", "RHEA:39499", "RHEA:39511", "RHEA:39523", "RHEA:39535", "RHEA:39547", "RHEA:39559", "RHEA:39579", "RHEA:39591", "RHEA:39603", "RHEA:39615", "RHEA:39627", "RHEA:39639", "RHEA:39687", "RHEA:39699", "RHEA:46720", "RHEA:67216", "RHEA:67228", "RHEA:72575", "RHEA:78863", "RHEA:78867", "RHEA:78931" ] } } }, { "id": "GO:0097265", "name": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-2161776 \"5S-HETE is oxidised to 5-oxoETE by 5-HEDH\"", "RHEA:48656" ], "previous": [ "Reactome:R-HSA-2161776 \"5S-HETE is oxidised to 5-oxoETE by 5-HEDH\"" ] } } }, { "id": "GO:0097621", "name": "monoamine oxidase activity", "changes": { "xrefs": { "current": [ "EC:1.4.3.4", "RHEA:26414", "RHEA:51168" ], "previous": [ "EC:1.4.3.4", "RHEA:26414" ] } } }, { "id": "GO:0102157", "name": "sulfopropanediol 3-dehydrogenase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.308", "MetaCyc:RXN-11727", "RHEA:28074 {status=\"skos:exactMatch\"}" ], "previous": [ "MetaCyc:RXN-11729" ] } } }, { "id": "GO:0102175", "name": "3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.418", "MetaCyc:RXN-11928", "RHEA:20669", "RHEA:34775", "RHEA:59016", "RHEA:60084", "RHEA:60092" ], "previous": [ "EC:1.1.1.418", "MetaCyc:RXN-11928", "RHEA:20669", "RHEA:34775", "RHEA:59016", "RHEA:60084" ] } } }, { "id": "GO:0102177", "name": "4alpha-monomethylsterol monooxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.18.11", "MetaCyc:RXN-19724", "RHEA:58868" ], "previous": [ "EC:1.14.18.11", "MetaCyc:RXN-11930", "RHEA:58872" ] } } }, { "id": "GO:0102232", "name": "acrolein reductase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-12281", "RHEA:64716" ], "previous": [ "MetaCyc:RXN-12281" ] } } }, { "id": "GO:0102394", "name": "L-isoleucine 4-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.11.45", "MetaCyc:RXN-13637", "RHEA:41448" ], "previous": [ "MetaCyc:RXN-13637" ] } } }, { "id": "GO:0102443", "name": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.337", "MetaCyc:RXN-13927", "Reactome:R-HSA-9971565 \"Unknown enzyme hydrogenates HPP\"", "RHEA:10176", "RHEA:15533", "RHEA:34555", "RHEA:36371" ], "previous": [ "EC:1.1.1.337", "MetaCyc:RXN-13927", "RHEA:10176", "RHEA:15533", "RHEA:34555", "RHEA:36371" ] } } }, { "id": "GO:0102673", "name": "fatty aldehyde dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-4142", "RHEA:44008", "RHEA:44016", "RHEA:49832", "RHEA:69092", "RHEA:69771" ], "previous": [ "MetaCyc:RXN-4142", "RHEA:44008", "RHEA:49832", "RHEA:69771" ] } } }, { "id": "GO:0102772", "name": "sphingolipid C4-monooxygenase activity", "changes": { "xrefs": { "current": [ "EC:1.14.18.5", "MetaCyc:RXN-14250", "Reactome:R-HSA-428260 \"DEGS2 oxygenates dihydroceramide\"", "RHEA:33599", "RHEA:33679", "RHEA:43116", "RHEA:46364", "RHEA:55476", "RHEA:55808", "RHEA:81475" ], "previous": [ "EC:1.14.18.5", "MetaCyc:RXN-14250", "Reactome:R-HSA-428260 \"DEGS2 oxygenates dihydroceramide\"", "RHEA:46364", "RHEA:55476", "RHEA:55808", "RHEA:81475" ] } } }, { "id": "GO:0102993", "name": "sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity", "changes": { "xrefs": { "current": [ "EC:1.14.19.35", "MetaCyc:RXN-1727", "MetaCyc:RXN-8295", "MetaCyc:RXN-8297", "MetaCyc:RXN-8299", "MetaCyc:RXN-8301", "MetaCyc:RXN-8303", "MetaCyc:RXN-8309", "MetaCyc:RXN-8310", "MetaCyc:RXN-8314", "MetaCyc:RXN-8365", "MetaCyc:RXN-8366", "MetaCyc:RXN-9667", "RHEA:46408", "RHEA:46412", "RHEA:66512", "RHEA:66516", "RHEA:66520" ], "previous": [ "EC:1.14.19.35", "MetaCyc:RXN-1727", "MetaCyc:RXN-8295", "MetaCyc:RXN-8297", "MetaCyc:RXN-8299", "MetaCyc:RXN-8301", "MetaCyc:RXN-8303", "MetaCyc:RXN-8309", "MetaCyc:RXN-8310", "MetaCyc:RXN-8314", "MetaCyc:RXN-8365", "MetaCyc:RXN-8366", "MetaCyc:RXN-9667", "RHEA:46408", "RHEA:46412" ] } } }, { "id": "GO:0106235", "name": "ceramide-1-phosphate phosphatase activity", "changes": { "xrefs": { "current": [ "RHEA:33743", "RHEA:50888", "RHEA:62040" ], "previous": [ "RHEA:33743", "RHEA:50888" ] } } }, { "id": "GO:0106262", "name": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.n7", "RHEA:32995", "RHEA:36015", "RHEA:36019", "RHEA:36023", "RHEA:37419", "RHEA:37495", "RHEA:37499", "RHEA:37503", "RHEA:37523", "RHEA:37575", "RHEA:37579", "RHEA:37727", "RHEA:37731", "RHEA:37767", "RHEA:37771", "RHEA:37775", "RHEA:64204", "RHEA:64228" ], "previous": [ "EC:2.3.1.n7", "RHEA:32995", "RHEA:36015", "RHEA:36019", "RHEA:36023", "RHEA:37495", "RHEA:37499", "RHEA:37503", "RHEA:37523", "RHEA:37575", "RHEA:37579", "RHEA:37727", "RHEA:37731", "RHEA:37767", "RHEA:37771", "RHEA:37775" ] } } }, { "id": "GO:0106263", "name": "1-acylglycerophosphoserine O-acyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.n6", "RHEA:33191", "RHEA:37375", "RHEA:37379", "RHEA:37399", "RHEA:37403", "RHEA:37407", "RHEA:37415", "RHEA:37531", "RHEA:37535", "RHEA:37539", "RHEA:37567", "RHEA:37571", "RHEA:37735", "RHEA:37739" ], "previous": [ "EC:2.3.1.n6", "RHEA:33191", "RHEA:37399", "RHEA:37403", "RHEA:37415", "RHEA:37531", "RHEA:37539", "RHEA:37567", "RHEA:37571", "RHEA:37735", "RHEA:37739" ] } } }, { "id": "GO:0106339", "name": "tRNA (cytidine(32)-2'-O-ribose)-methyltransferase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-11866", "Reactome:R-HSA-9024159 \"FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)\"", "RHEA:42932" ], "previous": [ "MetaCyc:RXN-11866", "RHEA:42932" ] } } }, { "id": "GO:0106341", "name": "omega-hydroxyceramide transacylase activity", "changes": { "xrefs": { "current": [ "EC:2.3.1.296", "MetaCyc:RXN-20362", "RHEA:55264", "RHEA:61528", "RHEA:65648", "RHEA:65652", "RHEA:65668", "RHEA:65672", "RHEA:65676", "RHEA:65680", "RHEA:65684", "RHEA:65688", "RHEA:65692", "RHEA:65696", "RHEA:78007", "RHEA:78011", "RHEA:78115", "RHEA:78119" ], "previous": [ "EC:2.3.1.296", "MetaCyc:RXN-20362", "RHEA:61528", "RHEA:65692", "RHEA:78115", "RHEA:78119" ] } } }, { "id": "GO:0106359", "name": "2-hydroxyacyl-CoA lyase activity", "changes": { "xrefs": { "current": [ "EC:4.1.2.63", "RHEA:25375", "RHEA:25379", "RHEA:67444", "RHEA:67448" ], "previous": [ "EC:4.1.2.63", "RHEA:25375", "RHEA:25379", "RHEA:67444" ] } } }, { "id": "GO:0106386", "name": "(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.n12", "MetaCyc:RXN66-485", "RHEA:32711", "RHEA:40191", "RHEA:40243", "RHEA:45832", "RHEA:67220", "RHEA:67232", "RHEA:78563", "RHEA:78579", "RHEA:78595", "RHEA:78607", "RHEA:78635", "RHEA:78667", "RHEA:78671", "RHEA:78871", "RHEA:78875", "RHEA:78879", "RHEA:78935", "RHEA:79191" ], "previous": [ "EC:1.1.1.n12", "MetaCyc:RXN66-485", "RHEA:32711", "RHEA:67220", "RHEA:67232", "RHEA:78871", "RHEA:78875", "RHEA:78879", "RHEA:78935" ] } } }, { "id": "GO:0106388", "name": "rRNA small subunit aminocarboxypropyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.5.1.157", "RHEA:31479", "RHEA:63292", "RHEA:63296", "RHEA:63300" ], "previous": [ "EC:2.5.1.157", "RHEA:63292", "RHEA:63296", "RHEA:63300" ] } } }, { "id": "GO:0106430", "name": "dihydroorotate dehydrogenase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.3.5.2", "RHEA:28687", "RHEA:28691", "RHEA:29195", "RHEA:29199", "RHEA:30187" ], "previous": [ "EC:1.3.5.2", "RHEA:28691", "RHEA:29195", "RHEA:30187" ] } } }, { "id": "GO:0106435", "name": "carboxylesterase activity", "changes": { "xrefs": { "current": [ "EC:3.1.1.1", "MetaCyc:CARBOXYLESTERASE-RXN", "Reactome:R-HSA-9619024 \"CES1 trimer hydrolyses ACEI pro-drugs to ACEIs\"", "Reactome:R-HSA-9727567 \"CES1 hydrolyses sacubitril to sacubitrilat\"", "Reactome:R-HSA-9749647 \"CES2 hydrolyzes ASA-\"", "RHEA:21164", "RHEA:31779", "RHEA:38555", "RHEA:47348", "RHEA:47352", "RHEA:47356", "RHEA:47360", "RHEA:47364", "RHEA:47388", "RHEA:47392", "RHEA:50136", "RHEA:50144", "RHEA:50148", "RHEA:59388", "RHEA:63052" ], "previous": [ "EC:3.1.1.1", "MetaCyc:CARBOXYLESTERASE-RXN", "Reactome:R-HSA-9619024 \"CES1 trimer hydrolyses ACEI pro-drugs to ACEIs\"", "Reactome:R-HSA-9727567 \"CES1 hydrolyses sacubitril to sacubitrilat\"", "Reactome:R-HSA-9749647 \"CES2 hydrolyzes ASA-\"", "RHEA:21164", "RHEA:31779", "RHEA:38555", "RHEA:50148", "RHEA:59388", "RHEA:63052" ] } } }, { "id": "GO:0106437", "name": "protein-glutamic acid ligase activity, initiating", "changes": { "xrefs": { "current": [ "RHEA:60144", "RHEA:69192", "RHEA:69196" ], "previous": [ "RHEA:60144", "RHEA:69192" ] } } }, { "id": "GO:0106438", "name": "protein-glutamic acid ligase activity, elongating", "changes": { "xrefs": { "current": [ "RHEA:60148", "RHEA:69208", "RHEA:69212" ], "previous": [ "RHEA:60148", "RHEA:69208" ] } } }, { "id": "GO:0120014", "name": "phospholipid transfer activity", "changes": { "xrefs": { "current": [ "Reactome:R-HSA-216757 \"4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane\"", "Reactome:R-HSA-382553 \"ABCA7:Apo1A-mediated phospholipid efflux\"", "Reactome:R-HSA-5678706 \"ABCB4 transports PC from plasma membrane to extracellular region\"", "Reactome:R-HSA-5678749 \"Defective ABCB4 does not transport PC from plasma membrane to extracellular region\"", "Reactome:R-HSA-8857662 \"ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane\"", "Reactome:R-HSA-8865637 \"MFSD2A transports LPC from extracellular region to plasma membrane\"", "Reactome:R-HSA-8867876 \"OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane\"" ], "previous": "N/A" } } }, { "id": "GO:0120502", "name": "fatty acid omega-1 hydroxylase activity", "changes": { "xrefs": { "current": [ "RHEA:39751", "RHEA:39759", "RHEA:41724", "RHEA:44548" ], "previous": [ "RHEA:39751", "RHEA:39759", "RHEA:44548" ] } } }, { "id": "GO:0120515", "name": "fatty acid-CoA ligase activity", "changes": { "xrefs": { "current": [ "MetaCyc:BUTYRATE--COA-LIGASE-RXN", "RHEA:38883", "RHEA:44004", "RHEA:44196" ], "previous": [ "MetaCyc:BUTYRATE--COA-LIGASE-RXN", "RHEA:38883", "RHEA:44004" ] } } }, { "id": "GO:0120516", "name": "diacylglycerol lipase activity", "changes": { "xrefs": { "current": [ "MetaCyc:RXN-19279", "RHEA:18761", "RHEA:32731", "RHEA:33275", "RHEA:35663", "RHEA:38383", "RHEA:38455", "RHEA:38483", "RHEA:38507", "RHEA:38511", "RHEA:38515", "RHEA:38519", "RHEA:38523", "RHEA:38595", "RHEA:38651", "RHEA:38659", "RHEA:39935", "RHEA:39939", "RHEA:40967", "RHEA:41219", "RHEA:42604", "RHEA:44176", "RHEA:44444", "RHEA:44712", "RHEA:44876", "RHEA:47868", "RHEA:48596", "RHEA:78019", "RHEA:78147" ], "previous": [ "MetaCyc:RXN-19279", "RHEA:32731", "RHEA:44444", "RHEA:47868", "RHEA:78019" ] } } }, { "id": "GO:0120521", "name": "4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.18.6", "MetaCyc:RXN3O-4042", "RHEA:46520", "RHEA:64532" ], "previous": [ "MetaCyc:RXN3O-4042", "RHEA:46520", "RHEA:64532" ] } } }, { "id": "GO:0120528", "name": "2-(omega-methylthio)alkylmalate dehydratase activity", "changes": { "xrefs": { "current": [ "EC:4.2.1.170", "RHEA:50632", "RHEA:50636", "RHEA:50648", "RHEA:50652", "RHEA:50656", "RHEA:50660" ], "previous": [ "EC:4.2.1.170", "RHEA:50632", "RHEA:50636" ] } } }, { "id": "GO:0120550", "name": "methyltransferase cap2 activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.296", "MetaCyc:RXN-14928", "RHEA:53044", "RHEA:67024" ], "previous": [ "EC:2.1.1.296", "MetaCyc:RXN-14928", "RHEA:67024" ] } } }, { "id": "GO:0140085", "name": "L-amino-acid N-acetyltransferase activity", "changes": { "xrefs": { "current": [ "RHEA:47656", "RHEA:47660", "RHEA:52680", "RHEA:83863" ], "previous": [ "RHEA:83863" ] } } }, { "id": "GO:0140169", "name": "3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity", "changes": { "xrefs": { "current": [ "EC:1.1.1.213", "EC:1.1.1.357", "EC:1.1.1.50", "RHEA:34779", "RHEA:34783", "RHEA:42116", "RHEA:69016", "RHEA:69028", "RHEA:84155", "RHEA:84199", "RHEA:85551", "RHEA:85559" ], "previous": [ "EC:1.1.1.213", "EC:1.1.1.357", "EC:1.1.1.50", "RHEA:34779", "RHEA:34783" ] } } }, { "id": "GO:0140293", "name": "ADP-ribosylglutamate-[protein] hydrolase activity", "changes": { "xrefs": { "current": [ "RHEA:58248" ], "previous": "N/A" } } }, { "id": "GO:0140318", "name": "protein transporter activity", "changes": { "xrefs": { "current": "N/A", "previous": [ "Reactome:R-HSA-2248891 \"M6PR transports activated ARSA to the lysosome\"", "Reactome:R-HSA-9662747 \"iRHOM2 transports ADAM17 from ER to the Golgi-network\"", "Reactome:R-HSA-9662818 \"iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane\"" ] } } }, { "id": "GO:0140324", "name": "lysophospholipase C activity", "changes": { "xrefs": { "current": [ "RHEA:86371", "RHEA:86375", "RHEA:86379", "RHEA:86383" ], "previous": [ "RHEA:86375", "RHEA:86379" ] } } }, { "id": "GO:0140386", "name": "tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.225", "Reactome:R-HSA-6788668 \"TRMT13 2'-O-methylates adenosine-4 in tRNA\"", "Reactome:R-HSA-6788684 \"TRMT13 2'-O-methylates cytidine-4 in tRNA\"", "RHEA:32767", "RHEA:43192", "RHEA:43196" ], "previous": [ "EC:2.1.1.225", "RHEA:32767", "RHEA:43192", "RHEA:43196" ] } } }, { "id": "GO:0140818", "name": "mRNA 5'-triphosphate monophosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.74", "MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN", "RHEA:11008", "RHEA:60828", "RHEA:60832", "RHEA:67004" ], "previous": [ "EC:3.6.1.74", "MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN", "RHEA:11008", "RHEA:67004" ] } } }, { "id": "GO:0140932", "name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.59", "RHEA:37099", "RHEA:37103", "RHEA:65384", "RHEA:65388" ], "previous": [ "EC:3.6.1.59", "RHEA:65384", "RHEA:65388" ] } } }, { "id": "GO:0140933", "name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "changes": { "xrefs": { "current": [ "EC:3.6.1.62", "RHEA:37371", "RHEA:60868", "RHEA:60872", "RHEA:67484" ], "previous": [ "EC:3.6.1.62", "RHEA:37371", "RHEA:67484" ] } } }, { "id": "GO:0160182", "name": "nitrate reductase (quinone) activity", "changes": { "xrefs": { "current": [ "EC:1.7.5.1", "RHEA:29119", "RHEA:29123", "RHEA:29127", "RHEA:29131", "RHEA:56144" ], "previous": [ "EC:1.7.5.1", "RHEA:29119", "RHEA:29127", "RHEA:56144" ] } } }, { "id": "GO:0160191", "name": "steroid 22S-hydroxylase activity", "changes": { "xrefs": { "current": [ "EC:1.14.14.178", "MetaCyc:RXN-22825", "MetaCyc:RXN-22826", "MetaCyc:RXN-22827", "RHEA:69831", "RHEA:69835", "RHEA:69839", "RHEA:69871", "RHEA:70003", "RHEA:70059", "RHEA:70063", "RHEA:70067", "RHEA:70071" ], "previous": [ "EC:1.14.14.178", "MetaCyc:RXN-22825", "MetaCyc:RXN-22826", "MetaCyc:RXN-22827", "RHEA:70059", "RHEA:70063", "RHEA:70067" ] } } }, { "id": "GO:0160302", "name": "6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity", "changes": { "xrefs": { "current": [ "EC:2.1.1.400", "KEGG_REACTION:R13499", "RHEA:85483" ], "previous": [ "KEGG_REACTION:R13499", "RHEA:85483" ] } } } ] }, "relations": { "biological_process": [ { "id": "GO:0000162", "name": "L-tryptophan biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009073", "GO:0046219", "GO:1902223" ], "previous": [ "GO:0006568", "GO:0009073", "GO:0046219", "GO:1902223" ] } } }, { "id": "GO:0001407", "name": "glycerophosphodiester transmembrane transport", "changes": { "is_a": { "current": [ "GO:0015748", "GO:0055085" ], "previous": [ "GO:0015711", "GO:0015748", "GO:0055085" ] } } }, { "id": "GO:0001820", "name": "serotonin secretion", "changes": { "is_a": { "current": [ "GO:0015850", "GO:0023061", "GO:0071705" ], "previous": [ "GO:0006837", "GO:0023061" ] } } }, { "id": "GO:0001927", "name": "exocyst assembly", "changes": { "is_a": { "current": [ "GO:0065003" ], "previous": [ "GO:0065003", "GO:0140029" ] }, "relationship": { "current": "N/A", "previous": [ "part_of GO:0006904" ] } } }, { "id": "GO:0001928", "name": "regulation of exocyst assembly", "changes": { "is_a": { "current": [ "GO:0043254" ], "previous": [ "GO:0043254", "GO:0106020" ] } } }, { "id": "GO:0006002", "name": "fructose 6-phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:1901135" ], "previous": [ "GO:0006796", "GO:0019637", "GO:1901135" ] } } }, { "id": "GO:0006003", "name": "fructose 2,6-bisphosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:1901135" ], "previous": [ "GO:0006796", "GO:0019637", "GO:1901135" ] } } }, { "id": "GO:0006173", "name": "dADP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009153", "GO:0009183", "GO:0009189", "GO:0046056" ], "previous": [ "GO:0009153", "GO:0009183", "GO:0046056" ] } } }, { "id": "GO:0006175", "name": "dATP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009153", "GO:0009202", "GO:0009216", "GO:0046060" ], "previous": [ "GO:0009153", "GO:0009216", "GO:0046060" ] } } }, { "id": "GO:0006185", "name": "dGDP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009153", "GO:0009183", "GO:0009189", "GO:0046066" ], "previous": [ "GO:0009153", "GO:0009183", "GO:0046066" ] } } }, { "id": "GO:0006203", "name": "dGTP catabolic process", "changes": { "is_a": { "current": [ "GO:0009155", "GO:0009204", "GO:0009217", "GO:0046070" ], "previous": [ "GO:0009155", "GO:0009217", "GO:0046070" ] } } }, { "id": "GO:0006227", "name": "dUDP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009189", "GO:0009197", "GO:0009221", "GO:0046077" ], "previous": [ "GO:0009197", "GO:0009221", "GO:0046077" ] } } }, { "id": "GO:0006229", "name": "dUTP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009202", "GO:0009212", "GO:0009221", "GO:0046080" ], "previous": [ "GO:0009212", "GO:0009221", "GO:0046080" ] } } }, { "id": "GO:0006235", "name": "dTTP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009202", "GO:0009212", "GO:0009221", "GO:0046075" ], "previous": [ "GO:0009212", "GO:0009221", "GO:0046075" ] } } }, { "id": "GO:0006240", "name": "dCDP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009189", "GO:0009197", "GO:0009221", "GO:0046062" ], "previous": [ "GO:0009197", "GO:0009221", "GO:0046062" ] } } }, { "id": "GO:0006242", "name": "dCTP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009202", "GO:0009212", "GO:0009221", "GO:0046065" ], "previous": [ "GO:0009212", "GO:0009221", "GO:0046065" ] } } }, { "id": "GO:0006251", "name": "dCDP catabolic process", "changes": { "is_a": { "current": [ "GO:0009192", "GO:0009198", "GO:0009223", "GO:0046062" ], "previous": [ "GO:0009198", "GO:0009223", "GO:0046062" ] } } }, { "id": "GO:0006253", "name": "dCTP catabolic process", "changes": { "is_a": { "current": [ "GO:0009204", "GO:0009213", "GO:0009223", "GO:0046065" ], "previous": [ "GO:0009213", "GO:0009223", "GO:0046065" ] } } }, { "id": "GO:0006257", "name": "dUDP catabolic process", "changes": { "is_a": { "current": [ "GO:0009192", "GO:0009198", "GO:0009223", "GO:0046077" ], "previous": [ "GO:0009198", "GO:0009223", "GO:0046077" ] } } }, { "id": "GO:0006523", "name": "alanine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008652", "GO:0046394" ], "previous": [ "GO:1901607" ] } } }, { "id": "GO:0006525", "name": "arginine metabolic process", "changes": { "is_a": { "current": [ "GO:0006520", "GO:0019752" ], "previous": [ "GO:1901605" ] } } }, { "id": "GO:0006530", "name": "L-asparagine catabolic process", "changes": { "is_a": { "current": [ "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006528", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006531", "name": "aspartate metabolic process", "changes": { "is_a": { "current": [ "GO:0006520", "GO:0043648" ], "previous": [ "GO:0043648", "GO:1901605" ] } } }, { "id": "GO:0006536", "name": "glutamate metabolic process", "changes": { "is_a": { "current": [ "GO:0006520", "GO:0043648" ], "previous": [ "GO:0043648", "GO:1901605" ] } } }, { "id": "GO:0006544", "name": "glycine metabolic process", "changes": { "is_a": { "current": [ "GO:0170039" ], "previous": [ "GO:0170039", "GO:1901605" ] } } }, { "id": "GO:0006546", "name": "glycine catabolic process", "changes": { "is_a": { "current": [ "GO:0006544", "GO:0009063", "GO:0170040" ], "previous": [ "GO:0006544", "GO:0170040", "GO:1901606" ] } } }, { "id": "GO:0006550", "name": "L-isoleucine catabolic process", "changes": { "is_a": { "current": [ "GO:0009083", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006549", "GO:0009083", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006559", "name": "L-phenylalanine catabolic process", "changes": { "is_a": { "current": [ "GO:0009074", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006558", "GO:0009074", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006566", "name": "L-threonine metabolic process", "changes": { "is_a": { "current": [ "GO:0170033", "GO:0170039" ], "previous": [ "GO:0019752" ] } } }, { "id": "GO:0006569", "name": "L-tryptophan catabolic process", "changes": { "is_a": { "current": [ "GO:0009074", "GO:0042436", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006568", "GO:0009074", "GO:0042436", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006571", "name": "L-tyrosine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009073", "GO:1902223" ], "previous": [ "GO:0006570", "GO:0009073", "GO:1902223" ] } } }, { "id": "GO:0006572", "name": "L-tyrosine catabolic process", "changes": { "is_a": { "current": [ "GO:0009074", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006570", "GO:0009074", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006574", "name": "L-valine catabolic process", "changes": { "is_a": { "current": [ "GO:0009083", "GO:0170035", "GO:0170040" ], "previous": [ "GO:0006573", "GO:0009083", "GO:0170035", "GO:0170040" ] } } }, { "id": "GO:0006583", "name": "melanin biosynthetic process from tyrosine", "changes": { "is_a": { "current": [ "GO:0042438" ], "previous": [ "GO:0006570", "GO:0042438" ] } } }, { "id": "GO:0006585", "name": "dopamine biosynthetic process from tyrosine", "changes": { "is_a": { "current": [ "GO:0042416" ], "previous": [ "GO:0006570", "GO:0042416" ] } } }, { "id": "GO:0006591", "name": "ornithine metabolic process", "changes": { "is_a": { "current": [ "GO:0170041" ], "previous": [ "GO:0170041", "GO:1901605" ] } } }, { "id": "GO:0006592", "name": "L-ornithine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0006591", "GO:0008652", "GO:0170043" ], "previous": [ "GO:0006591", "GO:0170043", "GO:1901607" ] } } }, { "id": "GO:0006603", "name": "phosphocreatine metabolic process", "changes": { "is_a": { "current": [ "GO:0006575", "GO:0019637" ], "previous": [ "GO:0006575", "GO:0006796", "GO:0019637" ] } } }, { "id": "GO:0006644", "name": "phospholipid metabolic process", "changes": { "is_a": { "current": [ "GO:0006629", "GO:0019637" ], "previous": [ "GO:0006629", "GO:0006796", "GO:0019637" ] } } }, { "id": "GO:0006753", "name": "nucleoside phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:0055086" ], "previous": [ "GO:0006796", "GO:0019637", "GO:0055086" ] } } }, { "id": "GO:0006796", "name": "phosphate-containing compound metabolic process", "changes": { "is_a": { "current": [ "GO:0008152" ], "previous": [ "GO:0006793" ] } } }, { "id": "GO:0006868", "name": "L-glutamine transport", "changes": { "is_a": { "current": [ "GO:0015804", "GO:0015807" ], "previous": [ "GO:0015695", "GO:0015804", "GO:0015807" ] } } }, { "id": "GO:0007023", "name": "post-chaperonin tubulin folding pathway", "changes": { "is_a": { "current": [ "GO:0007021" ], "previous": [ "GO:0006457" ] } } }, { "id": "GO:0008153", "name": "4-aminobenzoate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008652", "GO:0009073", "GO:0042537", "GO:0072330" ], "previous": [ "GO:0008652", "GO:0009073", "GO:0046482", "GO:0072330" ] } } }, { "id": "GO:0008612", "name": "peptidyl-hypusine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009058", "GO:0051604" ], "previous": [ "GO:0018205", "GO:0051604", "GO:1901607" ] } } }, { "id": "GO:0009070", "name": "serine family amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008652", "GO:0046394" ], "previous": [ "GO:1901607" ] } } }, { "id": "GO:0009090", "name": "L-homoserine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009092", "GO:0170034", "GO:0170043" ], "previous": [ "GO:0009070", "GO:0009092", "GO:0170034", "GO:0170043" ] } } }, { "id": "GO:0009094", "name": "L-phenylalanine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009073", "GO:1902223" ], "previous": [ "GO:0006558", "GO:0009073", "GO:1902223" ] } } 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"GO:1901136" ] } } }, { "id": "GO:0034194", "name": "D-galactonate catabolic process", "changes": { "is_a": { "current": [ "GO:0016052", "GO:0046176" ], "previous": [ "GO:0016052", "GO:0019584" ] } } }, { "id": "GO:0034195", "name": "L-galactonate catabolic process", "changes": { "is_a": { "current": [ "GO:0016052", "GO:0046176" ], "previous": [ "GO:0016052", "GO:0019584" ] } } }, { "id": "GO:0034229", "name": "ethanolamine transport", "changes": { "is_a": { "current": [ "GO:0015837", "GO:0015850" ], "previous": [ "GO:0015695", "GO:0015837", "GO:0015850" ] } } }, { "id": "GO:0034254", "name": "regulation of urea catabolic process", "changes": { "is_a": { "current": [ "GO:0009894", "GO:0062012" ], "previous": [ "GO:0009894", "GO:0062012", "GO:1903314" ] } } }, { "id": "GO:0034354", "name": "'de novo' NAD+ biosynthetic process from L-tryptophan", "changes": { "is_a": { "current": [ "GO:0009072", "GO:0009435", "GO:0042430", "GO:0170033", "GO:0170039" ], "previous": [ "GO:0006568", 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[ "GO:0009058", "GO:0042618" ], "previous": [ "GO:0042618", "GO:1901441" ] } } }, { "id": "GO:0042816", "name": "vitamin B6 metabolic process", "changes": { "is_a": { "current": [ "GO:0006766", "GO:0072524" ], "previous": [ "GO:0072524" ] } } }, { "id": "GO:0042822", "name": "pyridoxal 5'-phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0006081", "GO:0019637", "GO:0042816" ], "previous": [ "GO:0006081", "GO:0006796", "GO:0019637", "GO:0042816" ] } } }, { "id": "GO:0042836", "name": "D-glucarate metabolic process", "changes": { "is_a": { "current": [ "GO:0005975", "GO:0019752" ], "previous": [ "GO:0005975", "GO:0043648" ] } } }, { "id": "GO:0042837", "name": "D-glucarate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0016051", "GO:0019578", "GO:0042836" ], "previous": [ "GO:0016051", "GO:0019393", "GO:0042836" ] } } }, { "id": "GO:0042869", "name": "aldarate transmembrane transport", "changes": { "is_a": { "current": [ "GO:1905039" ], "previous": [ "GO:0006835", "GO:1905039" ] } } }, { "id": "GO:0042883", "name": "L-cysteine transport", "changes": { "is_a": { "current": [ "GO:0000101", "GO:0015804", "GO:0015807" ], "previous": [ "GO:0000101", "GO:0015695", "GO:0015804" ] } } }, { "id": "GO:0042918", "name": "alkanesulfonate transmembrane transport", "changes": { "is_a": { "current": [ "GO:0015849", "GO:0055085", "GO:0072348" ], "previous": [ "GO:0015711", "GO:0015849", "GO:0055085", "GO:0072348" ] } } }, { "id": "GO:0042930", "name": "enterobactin transport", "changes": { "is_a": { "current": [ "GO:0015850", "GO:0015891" ], "previous": [ "GO:0015711", "GO:0015850", "GO:0015891" ] } } }, { "id": "GO:0043215", "name": "daunorubicin transport", "changes": { "is_a": { "current": [ "GO:0071705", "GO:1901656" ], "previous": [ "GO:0015695", "GO:0071705", "GO:1901656" ] } } }, { "id": "GO:0043251", "name": "sodium-dependent organic anion transport", "changes": { "is_a": { "current": [ "GO:0055085" ], "previous": [ "GO:0015711" ] } } }, { "id": "GO:0043252", "name": "sodium-independent organic anion transport", "changes": { "is_a": { "current": [ "GO:0055085" ], "previous": [ "GO:0015711" ] } } }, { "id": "GO:0043436", "name": "oxoacid metabolic process", "changes": { "is_a": { "current": [ "GO:0044281" ], "previous": [ "GO:0006082" ] } } }, { "id": "GO:0043545", "name": "molybdopterin cofactor metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:0051189" ], "previous": [ "GO:0006796", "GO:0019637", "GO:0051189" ] } } }, { "id": "GO:0043647", "name": "inositol phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:0019751" ], "previous": [ "GO:0006796", "GO:0019637", "GO:0019751" ] } } }, { "id": "GO:0045039", "name": "protein insertion into mitochondrial inner membrane", "changes": { "is_a": { "current": [ "GO:0007007", "GO:7770058" ], "previous": [ "GO:0007007", "GO:0051204" ] } } }, { "id": "GO:0045041", "name": "protein import into mitochondrial intermembrane space", "changes": { "is_a": { "current": [ "GO:7770058" ], "previous": [ "GO:0010496", "GO:0070585", "GO:0071806", "GO:0072594" ] } } }, { "id": "GO:0045337", "name": "trans, trans-farnesyl diphosphate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008654", "GO:0016114", "GO:0045338", "GO:0050993" ], "previous": [ "GO:0008654", "GO:0016114", "GO:0045338" ] } } }, { "id": "GO:0045443", "name": "juvenile hormone secretion", "changes": { "is_a": { "current": [ "GO:0046865", "GO:0046879", "GO:0140353" ], "previous": [ "GO:0046865", "GO:0060986", "GO:0140353" ] } } }, { "id": "GO:0045936", "name": "negative regulation of phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0009892" ], "previous": [ "GO:0010563" ] } } }, { "id": "GO:0045937", "name": "positive regulation of phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0009893" ], "previous": [ "GO:0010562" ] } } }, { "id": "GO:0045980", "name": "negative regulation of nucleotide metabolic process", "changes": { "is_a": { "current": [ "GO:0006140", "GO:0010563", "GO:0045934", "GO:0062014" ], "previous": [ "GO:0006140", "GO:0045934", "GO:0045936", "GO:0062014" ] } } }, { "id": "GO:0045981", "name": "positive regulation of nucleotide metabolic process", "changes": { "is_a": { "current": [ "GO:0006140", "GO:0010562", "GO:0062013" ], "previous": [ "GO:0006140", "GO:0045937", "GO:0062013" ] } } }, { "id": "GO:0046057", "name": "dADP catabolic process", "changes": { "is_a": { "current": [ "GO:0009155", "GO:0009184", "GO:0009192", "GO:0046056" ], "previous": [ "GO:0009155", "GO:0009184", "GO:0046056" ] } } }, { "id": "GO:0046060", "name": "dATP metabolic process", "changes": { "is_a": { "current": [ "GO:0009151", "GO:0009200", "GO:0009215" ], "previous": [ "GO:0009151", "GO:0009215" ] } } }, { "id": "GO:0046061", "name": "dATP catabolic process", "changes": { "is_a": { "current": [ "GO:0009155", "GO:0009204", "GO:0009217", "GO:0046060" ], "previous": [ "GO:0009155", "GO:0009217", "GO:0046060" ] } } }, { "id": "GO:0046065", "name": "dCTP metabolic process", "changes": { "is_a": { "current": [ "GO:0009200", "GO:0009211", "GO:0009219" ], "previous": [ "GO:0009211", "GO:0009219" ] } } }, { "id": "GO:0046067", "name": "dGDP catabolic process", "changes": { "is_a": { "current": [ "GO:0009155", "GO:0009184", "GO:0009192", "GO:0046066" ], "previous": [ "GO:0009155", "GO:0009184", "GO:0046066" ] } } }, { "id": "GO:0046070", "name": "dGTP metabolic process", "changes": { "is_a": { "current": [ "GO:0009151", "GO:0009200", "GO:0009215" ], "previous": [ "GO:0009151", "GO:0009215" ] } } }, { "id": "GO:0046071", "name": "dGTP biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009153", "GO:0009202", "GO:0009216", "GO:0046070" ], "previous": [ "GO:0009153", "GO:0009216", "GO:0046070" ] } } }, { "id": "GO:0046075", "name": "dTTP metabolic process", "changes": { "is_a": { "current": [ "GO:0009200", "GO:0009211", "GO:0009219" ], "previous": [ "GO:0009211", "GO:0009219" ] } } }, { "id": "GO:0046076", "name": "dTTP catabolic process", "changes": { "is_a": { "current": [ "GO:0009204", "GO:0009213", "GO:0009223", "GO:0046075" ], "previous": [ "GO:0009213", "GO:0009223", "GO:0046075" ] } } }, { "id": "GO:0046080", "name": "dUTP metabolic process", "changes": { "is_a": { "current": [ "GO:0009200", "GO:0009211", "GO:0009219" ], "previous": [ "GO:0009211", "GO:0009219" ] } } }, { "id": "GO:0046081", "name": "dUTP catabolic process", "changes": { "is_a": { "current": [ "GO:0009204", "GO:0009213", "GO:0009223", "GO:0046080" ], "previous": [ "GO:0009213", "GO:0009223", "GO:0046080" ] } } }, { "id": "GO:0046179", "name": "keto-D-gluconate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0046175" ], "previous": [ "GO:0046180" ] } } }, { "id": "GO:0046230", "name": "2-aminobenzenesulfonate catabolic process", "changes": { "is_a": { "current": [ "GO:0009310", "GO:0042178", "GO:0042537", "GO:0044273" ], "previous": [ "GO:0009310", "GO:0016054", "GO:0042178", "GO:0042537", "GO:0044273" ] } } }, { "id": "GO:0046239", "name": "phthalate catabolic process", "changes": { "is_a": { "current": [ "GO:0018963", "GO:0042178", "GO:0043649" ], "previous": [ "GO:0018963", "GO:0042178", "GO:0046395" ] } } }, { "id": "GO:0046269", "name": "toluene-4-sulfonate catabolic process", "changes": { "is_a": { "current": [ "GO:0044273", "GO:0044282", "GO:0072491" ], "previous": [ "GO:0016054", "GO:0044273", "GO:0072491" ] } } }, { "id": "GO:0046305", "name": "alkanesulfonate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0019694", "GO:0044272" ], "previous": [ "GO:0016053", "GO:0019694", "GO:0044272" ] } } }, { "id": "GO:0046306", "name": "alkanesulfonate catabolic process", "changes": { "is_a": { "current": [ "GO:0019694", "GO:0044273" ], "previous": [ "GO:0016054", "GO:0019694", "GO:0044273" ] } } }, { "id": "GO:0046357", "name": "D-galactarate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0016051", "GO:0019578", "GO:0019580", "GO:0043650" ], "previous": [ "GO:0016051", "GO:0019578", "GO:0019580" ] } } }, { "id": "GO:0046385", "name": "deoxyribose phosphate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0090407", "GO:1901137" ], "previous": [ "GO:0006796", "GO:0090407", "GO:1901137" ] } } }, { "id": "GO:0046386", "name": "deoxyribose phosphate catabolic process", "changes": { "is_a": { "current": [ "GO:0046434", "GO:1901136" ], "previous": [ "GO:0006796", "GO:0046434", "GO:1901136" ] } } }, { "id": "GO:0046392", "name": "D-galactarate catabolic process", "changes": { "is_a": { "current": [ "GO:0016052", "GO:0019579", "GO:0019580", "GO:0043649" ], "previous": [ "GO:0016052", "GO:0019579", "GO:0019580" ] } } }, { "id": "GO:0046394", "name": "carboxylic acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0019752", "GO:0044283" ], "previous": [ "GO:0016053", "GO:0019752" ] } } }, { "id": "GO:0046395", "name": "carboxylic acid catabolic process", "changes": { "is_a": { "current": [ "GO:0019752", "GO:0044282" ], "previous": [ "GO:0016054", "GO:0019752" ] } } }, { "id": "GO:0046416", "name": "D-amino acid metabolic process", "changes": { "is_a": { "current": [ "GO:0170041" ], "previous": [ "GO:0170041", "GO:1901605" ] } } }, { "id": "GO:0046437", "name": "D-amino acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0008652", "GO:0046416", "GO:0170043" ], "previous": [ "GO:0046416", "GO:0170043", "GO:1901607" ] } } }, { "id": "GO:0046942", "name": "carboxylic acid transport", "changes": { "is_a": { "current": [ "GO:0015849" ], "previous": [ "GO:0015711", "GO:0015849" ] } } }, { "id": "GO:0046951", "name": "ketone body biosynthetic process", "changes": { "is_a": { "current": [ "GO:0044283", "GO:1901570" ], "previous": [ "GO:0044283", "GO:1901570", "GO:1902224" ] } } }, { "id": "GO:0046952", "name": "ketone body catabolic process", "changes": { "is_a": { "current": [ "GO:0044282", "GO:1901569" ], "previous": [ "GO:0044282", "GO:1901569", "GO:1902224" ] } } }, { "id": "GO:0046963", "name": "3'-phosphoadenosine 5'-phosphosulfate transport", "changes": { "is_a": { "current": [ "GO:0015868", "GO:0051503", "GO:0072348" ], "previous": [ "GO:0015711", "GO:0015868", "GO:0051503", "GO:0072348" ] } } }, { "id": "GO:0048200", "name": "Golgi transport vesicle coating", "changes": { "relationship": { "current": [ "part_of GO:0048194" ], "previous": [ "part_of GO:0048194", "part_of GO:0048199" ] } } }, { "id": "GO:0048208", "name": "COPII vesicle coat assembly", "changes": { "relationship": { "current": [ "part_of GO:0090114" ], "previous": [ "part_of GO:0048207", "part_of GO:0090114" ] } } }, { "id": "GO:0048242", "name": "epinephrine secretion", "changes": { "is_a": { "current": [ "GO:0050432" ], "previous": [ "GO:0048241", "GO:0050432" ] } } }, { "id": "GO:0048243", "name": "norepinephrine secretion", "changes": { "is_a": { "current": [ "GO:0023061", "GO:0050432" ], "previous": [ "GO:0015874", "GO:0023061", "GO:0050432" ] } } }, { "id": "GO:0050432", "name": "catecholamine secretion", "changes": { "is_a": { "current": [ "GO:0015850", "GO:0032940", "GO:0071705" ], "previous": [ "GO:0032940", "GO:0051937" ] } } }, { "id": "GO:0050667", "name": "homocysteine metabolic process", "changes": { "is_a": { "current": [ "GO:0000096", "GO:0170041" ], "previous": [ "GO:0000096", "GO:0170041", "GO:1901605" ] } } }, { "id": "GO:0050845", "name": "teichuronic acid biosynthetic process", "changes": { "is_a": { "current": [ "GO:0044038", "GO:0044283" ], "previous": [ "GO:0016053", "GO:0044038" ] } } }, { "id": "GO:0051156", "name": "glucose 6-phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:1901135" ], "previous": [ "GO:0006796", "GO:0019637", "GO:1901135" ] } } }, { "id": "GO:0051167", "name": "D-xylulose 5-phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:1901135" ], "previous": [ "GO:0006796", "GO:0019637", "GO:1901135" ] } } }, { "id": "GO:0051458", "name": "corticotropin secretion", "changes": { "is_a": { "current": [ "GO:0030072" ], "previous": [ "GO:0030072", "GO:0060986" ] } } }, { "id": "GO:0051610", "name": "serotonin uptake", "changes": { "is_a": { "current": [ "GO:0015850", "GO:0071705", "GO:0098810" ], "previous": [ "GO:0006837", "GO:0098810" ] } } }, { "id": "GO:0051620", "name": "norepinephrine uptake", "changes": { "is_a": { "current": [ "GO:0090493" ], "previous": [ "GO:0015874", "GO:0090493" ] } } }, { "id": "GO:0052646", "name": "alditol phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637", "GO:1901135" ], "previous": [ "GO:0006796", "GO:0019637", "GO:1901135" ] } } }, { "id": "GO:0052699", "name": "ergothioneine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0000097", "GO:0006578", "GO:0052703" ], "previous": [ "GO:0000097", "GO:0006578", "GO:0052698", "GO:0052703" ] } } }, { "id": "GO:0052700", "name": "ergothioneine catabolic process", 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GO:0061720" ] } } }, { "id": "GO:0062089", "name": "regulation of taurine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009889", "GO:0042762" ], "previous": [ "GO:0009889", "GO:0042762", "GO:0062012" ] } } }, { "id": "GO:0062090", "name": "positive regulation of taurine biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009891", "GO:0062089" ], "previous": [ "GO:0009891", "GO:0062013", "GO:0062089" ] } } }, { "id": "GO:0070162", "name": "adiponectin secretion", "changes": { "is_a": { "current": [ "GO:0009306", "GO:0046879" ], "previous": [ "GO:0009306", "GO:0060986" ] } } }, { "id": "GO:0070408", "name": "carbamoyl phosphate metabolic process", "changes": { "is_a": { "current": [ "GO:0019637" ], "previous": [ "GO:0006796", "GO:0019637" ] } } }, { "id": "GO:0070617", "name": "negative regulation of thiamine diphosphate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009890", "GO:0010563", "GO:0046137", "GO:0070616" ], "previous": [ 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{ "id": "GO:1901128", "name": "gentamycin metabolic process", "changes": { "is_a": { "current": [ "GO:0008152" ], "previous": [ "GO:0016137", "GO:0019751" ] } } }, { "id": "GO:1901129", "name": "gentamycin catabolic process", "changes": { "is_a": { "current": [ "GO:0009056", "GO:1901128" ], "previous": [ "GO:0030649", "GO:0046174", "GO:1901128" ] } } }, { "id": "GO:1901130", "name": "gentamycin biosynthetic process", "changes": { "is_a": { "current": [ "GO:0009058", "GO:1901128" ], "previous": [ "GO:0030648", "GO:0046173", "GO:1901128" ] } } }, { "id": "GO:1901276", "name": "tartrate catabolic process", "changes": { "is_a": { "current": [ "GO:0016052", "GO:0019579", "GO:0043649", "GO:1901275" ], "previous": [ "GO:0016052", "GO:0019579", "GO:1901275" ] } } }, { "id": "GO:1901277", "name": "tartrate biosynthetic process", "changes": { "is_a": { "current": [ "GO:0016051", "GO:0019578", "GO:0043650", "GO:1901275" ], "previous": [ "GO:0016051", "GO:0019578", "GO:1901275" ] } } }, { "id": 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"name": "serine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0016413", "name": "O-acetyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016407" ], "previous": [ "GO:0008374", "GO:0016407" ] } } }, { "id": "GO:0016414", "name": "diglucosylglycerate octanoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0016416", "name": "O-palmitoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016409" ], "previous": [ "GO:0008374", "GO:0016409" ] } } }, { "id": "GO:0016418", "name": "S-acetyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016407" ], "previous": [ "GO:0016407", "GO:0016417" ] } } }, { "id": "GO:0016419", "name": "S-malonyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016420" ], "previous": [ "GO:0016417", "GO:0016420" ] } } }, { "id": "GO:0016453", "name": "C-acetyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016407" ], "previous": [ "GO:0016407", "GO:0016408" ] } } }, { "id": "GO:0016454", "name": "C-palmitoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016409" ], "previous": [ "GO:0016408", "GO:0016409" ] } } }, { "id": "GO:0016710", "name": "trans-cinnamate 4-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0016711", "name": "flavonoid 3'-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0016749", "name": "N-succinyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016748" ], "previous": [ "GO:0016410", "GO:0016748" ] } } }, { "id": "GO:0016750", "name": "O-succinyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016748" ], "previous": [ "GO:0008374", "GO:0016748" ] } } }, { "id": "GO:0016751", "name": "S-succinyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016748" ], "previous": [ "GO:0016417", "GO:0016748" ] } } }, { "id": "GO:0016753", "name": "O-sinapoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016752" ], "previous": [ "GO:0008374", "GO:0016752" ] } } }, { "id": "GO:0018031", "name": "peptidyl-lysine N6-palmitoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747", "GO:0140096" ], "previous": [ "GO:0016410", "GO:0140096" ] } } }, { "id": "GO:0018525", "name": "4-hydroxybenzoyl-CoA reductase activity", "changes": { "is_a": { "current": [ "GO:0016614" ], "previous": [ "GO:0016636" ] } } }, { "id": "GO:0018554", "name": "1,2-dihydroxynaphthalene dioxygenase activity", "changes": { "is_a": { "current": [ "GO:0016702" ], "previous": [ "GO:0016701", "GO:0051213" ] } } }, { "id": "GO:0018570", "name": "p-cumate 2,3-dioxygenase activity", "changes": { "is_a": { "current": [ "GO:0016708" ], "previous": [ "GO:0016702" ] } } }, { "id": "GO:0018664", "name": "benzoate 4-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0019707", "name": "protein-cysteine S-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747", "GO:0140096" ], "previous": [ "GO:0016417", "GO:0140096" ] } } }, { "id": "GO:0030270", "name": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0032216", "name": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0032441", "name": "pheophorbide a oxygenase activity", "changes": { "is_a": { "current": [ "GO:0016713" ], "previous": [ "GO:0016730" ] } } }, { "id": "GO:0032576", "name": "O-linoleoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0033229", "name": "L-cysteine transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0000099", "GO:0015175", "GO:0015179" ], "previous": [ "GO:0000099", "GO:0015175" ] } } }, { "id": "GO:0033717", "name": "gluconate 2-dehydrogenase (acceptor) activity", "changes": { "is_a": { "current": [ "GO:0016614" ], "previous": [ "GO:0008875" ] } } }, { "id": "GO:0033759", "name": "flavone synthase activity", "changes": { "is_a": { "current": [ "GO:0050498" ], "previous": [ "GO:0016706" ] } } }, { "id": "GO:0033772", "name": "flavonoid 3',5'-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0033775", "name": "deoxysarpagine hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0033777", "name": "lithocholate 6beta-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0033781", "name": "cholesterol 24-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0033813", "name": "deacetylcephalosporin-C acetyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016408" ] } } }, { "id": "GO:0033814", "name": "propanoyl-CoA C-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016408" ] } } }, { "id": "GO:0034318", "name": "alcohol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0034353", "name": "mRNA 5'-diphosphatase activity", "changes": { "is_a": { "current": [ "GO:0004651", "GO:0016462", "GO:0140098" ], "previous": [ "GO:0016462", "GO:0140098" ] } } }, { "id": "GO:0034590", "name": "L-hydroxyproline transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015179", "GO:0072349" ], "previous": [ "GO:0008028", "GO:0015179", "GO:0072349" ] } } }, { "id": "GO:0035599", "name": "aspartic acid methylthiotransferase activity", "changes": { "relationship": { "current": "N/A", "previous": [ "part_of GO:0018339" ] } } }, { "id": "GO:0036189", "name": "abieta-7,13-diene hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0036199", "name": "cholest-4-en-3-one 26-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016713" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0036201", "name": "ent-isokaurene C2-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0036202", "name": "ent-cassa-12,15-diene 11-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0036204", "name": "abieta-7,13-dien-18-ol hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0036209", "name": "9beta-pimara-7,15-diene oxidase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0042878", "name": "D-glucarate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015144", "GO:0042876" ], "previous": [ "GO:0005310", "GO:0015144", "GO:0042876" ] } } }, { "id": "GO:0042879", "name": "aldonate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028" ], "previous": [ "GO:0046943" ] } } }, { "id": "GO:0042925", "name": "benzoate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0008028", "GO:0042910" ], "previous": [ "GO:0042910", "GO:0046943" ] } } }, { "id": "GO:0042933", "name": "chrysobactin transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015343", "GO:0015665", "GO:0046943", "GO:0071916" ], "previous": [ "GO:0008028", "GO:0015343", "GO:0015665", "GO:0071916" ] } } }, { "id": "GO:0043808", "name": "lyso-ornithine lipid acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0043810", "name": "ornithine-acyl [acyl carrier protein] N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0044104", "name": "2,5-dioxovalerate dehydrogenase (NAD+) activity", "changes": { "is_a": { "current": [ "GO:0004029" ], "previous": [ "GO:0016620" ] } } }, { "id": "GO:0044183", "name": "protein folding chaperone", "changes": { "relationship": { "current": [ "part_of GO:0006457" ], "previous": [ "has_part GO:0051082", "part_of GO:0006457" ] } } }, { "id": "GO:0044684", "name": "dihydromethanopterin reductase activity", "changes": { "is_a": { "current": [ "GO:0016645" ], "previous": [ "GO:0016646" ] } } }, { "id": "GO:0044875", "name": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "changes": { "relationship": { "current": [ "part_of GO:0052699" ], "previous": [ "part_of GO:0052704" ] } } }, { "id": "GO:0045431", "name": "flavonol synthase activity", "changes": { "is_a": { "current": [ "GO:0050498" ], "previous": [ "GO:0016706" ] } } }, { "id": "GO:0047081", "name": "3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase [NAD(P)H] activity", "changes": { "is_a": { "current": [ "GO:0016709" ], "previous": [ "GO:0016708" ] } } }, { "id": "GO:0047082", "name": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047083", "name": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047084", "name": "methyltetrahydroprotoberberine 14-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047087", "name": "protopine 6-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047088", "name": "dihydrosanguinarine 10-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047089", "name": "dihydrochelirubine 12-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0047091", "name": "L-lysine 6-monooxygenase (NADPH) activity", "changes": { "is_a": { "current": [ "GO:0016709" ], "previous": [ "GO:0016703", "GO:0016709" ] } } }, { "id": "GO:0047111", "name": "formate dehydrogenase (cytochrome-c-553) activity", "changes": { "is_a": { "current": [ "GO:0016725" ], "previous": [ "GO:0016622" ] } } }, { "id": "GO:0047144", "name": "2-acylglycerol-3-phosphate O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0042171" ], "previous": [ "GO:0008374", "GO:0042171" ] } } }, { "id": "GO:0047159", "name": "plasmalogen synthase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047166", "name": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047167", "name": "1-alkyl-2-acetylglycerol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047173", "name": "phosphatidylcholine-retinol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047174", "name": "putrescine N-hydroxycinnamoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0050734" ], "previous": [ "GO:0016410", "GO:0050734" ] } } }, { "id": "GO:0047175", "name": "galactosylacylglycerol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047184", "name": "1-acylglycerophosphocholine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047190", "name": "2-acylglycerophosphocholine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047191", "name": "1-alkylglycerophosphocholine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047194", "name": "indoleacetylglucose-inositol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047195", "name": "diacylglycerol-sterol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047196", "name": "long-chain-alcohol O-fatty-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047197", "name": "triglyceride-sterol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047199", "name": "phosphatidylcholine-dolichol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047594", "name": "6-beta-hydroxyhyoscyamine epoxidase activity", "changes": { "is_a": { "current": [ "GO:0050498" ], "previous": [ "GO:0016706" ] } } }, { "id": "GO:0047872", "name": "dolichol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047899", "name": "formate dehydrogenase (NADP+) activity", "changes": { "is_a": { "current": [ "GO:0016726" ], "previous": [ "GO:0016620" ] } } }, { "id": "GO:0047909", "name": "galactolipid O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0047957", "name": "4'-methoxyisoflavone 2'-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0048000", "name": "isoflavone 3'-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050252", "name": "retinol O-fatty-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0050291", "name": "sphingosine N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0050588", "name": "apo-beta-carotenoid-14',13'-dioxygenase activity", "changes": { "is_a": { "current": [ "GO:0016702" ], "previous": [ "GO:0016703" ] } } }, { "id": "GO:0050589", "name": "leucocyanidin oxygenase activity", "changes": { "is_a": { "current": [ "GO:0050498" ], "previous": [ "GO:0016706" ] } } }, { "id": "GO:0050591", "name": "quinine 3-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050592", "name": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050593", "name": "N-methylcoclaurine 3'-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050594", "name": "tabersonine 16-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050596", "name": "vinorine hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050597", "name": "taxane 10-beta-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050598", "name": "taxane 13-alpha-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0050607", "name": "S-(hydroxymethyl)mycothiol dehydrogenase activity", "changes": { "is_a": { "current": [ "GO:0016616" ], "previous": [ "GO:0016620" ] } } }, { "id": "GO:0050616", "name": "secologanin synthase activity", "changes": { "is_a": { "current": [ "GO:0016717" ], "previous": [ "GO:0016634" ] } } }, { "id": "GO:0050633", "name": "acetyl-CoA C-myristoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0019107" ], "previous": [ "GO:0016408", "GO:0019107" ] } } }, { "id": "GO:0050640", "name": "isopenicillin-N N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0050735", "name": "N-malonyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016420" ], "previous": [ "GO:0016410", "GO:0016420" ] } } }, { "id": "GO:0050736", "name": "O-malonyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016420" ], "previous": [ "GO:0008374", "GO:0016420" ] } } }, { "id": "GO:0050737", "name": "O-hydroxycinnamoyltransferase activity", "changes": { "is_a": { "current": [ "GO:0050734" ], "previous": [ "GO:0008374", "GO:0050734" ] } } }, { "id": "GO:0052851", "name": "ferric-chelate reductase (NADPH) activity", "changes": { "is_a": { "current": [ "GO:0000293" ], "previous": [ "GO:0000293", "GO:0016723" ] } } }, { "id": "GO:0061579", "name": "N-acyl homoserine lactone synthase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0061686", "name": "hercynylcysteine sulfoxide synthase activity", "changes": { "relationship": { "current": [ "part_of GO:0052699" ], "previous": [ "part_of GO:0140479" ] } } }, { "id": "GO:0061920", "name": "protein propionyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0070007", "name": "glutamic-type endopeptidase activity", "changes": { "is_a": { "current": [ "GO:0004175", "GO:0070002" ], "previous": "N/A" } } }, { "id": "GO:0070906", "name": "aspartate:alanine antiporter activity", "changes": { "is_a": { "current": [ "GO:0015297", "GO:0015556", "GO:0022858" ], "previous": [ "GO:0005310", "GO:0015297", "GO:0015556", "GO:0022858" ] } } }, { "id": "GO:0070909", "name": "glutamate:gamma-aminobutyric acid antiporter activity", "changes": { "is_a": { "current": [ "GO:0005310", "GO:0015185", "GO:0015297", "GO:0015355" ], "previous": [ "GO:0015185", "GO:0015297", "GO:0015355" ] } } }, { "id": "GO:0080072", "name": "spermidine:sinapoyl CoA N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0080073", "name": "spermidine:coumaroyl CoA N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0080074", "name": "spermidine:caffeoyl CoA N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0080075", "name": "spermidine:feruloyl CoA N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0080089", "name": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0080095", "name": "phosphatidylethanolamine-sterol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0080096", "name": "phosphatidate-sterol O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0090447", "name": "glycerol-3-phosphate 2-O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0102001", "name": "isoleucine N-monooxygenase (oxime forming) activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102002", "name": "valine N-monooxygenase (oxime forming) activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102068", "name": "alpha-humulene 10-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102170", "name": "5-epi-aristolochene-1,3-dihydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102177", "name": "4alpha-monomethylsterol monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016716" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102289", "name": "beta-amyrin 11-oxidase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102320", "name": "1,8-cineole 2-exo-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102375", "name": "11-oxo-beta-amyrin 30-oxidase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102394", "name": "L-isoleucine 4-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016706" ], "previous": [ "GO:0016616" ] } } }, { "id": "GO:0102556", "name": "dammarenediol 12-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102557", "name": "protopanaxadiol 6-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102596", "name": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102597", "name": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102598", "name": "3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102684", "name": "L-phenylalanine N-monooxygenase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102717", "name": "DIBOA-glucoside oxygenase activity", "changes": { "is_a": { "current": [ "GO:0016706" ], "previous": [ "GO:0050498" ] } } }, { "id": "GO:0102811", "name": "geraniol 10-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102876", "name": "psoralen synthase (NADPH) activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102915", "name": "piperitol synthase activity", "changes": { "is_a": { "current": [ "GO:0016717" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102934", "name": "costunolide synthase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0102995", "name": "angelicin synthase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0106075", "name": "peptide N-succinyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0106144", "name": "fraxetin 5-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0106145", "name": "scopoletin 8-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016706" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0106149", "name": "indole-3-carbonyl nitrile 4-hydroxylase activity", "changes": { "is_a": { "current": [ "GO:0016712" ], "previous": [ "GO:0016709" ] } } }, { "id": "GO:0106226", "name": "peptide 2-hydroxyisobutyryltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0106228", "name": "peptide glutaryltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0106262", "name": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0106263", "name": "1-acylglycerophosphoserine O-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0008374" ] } } }, { "id": "GO:0120294", "name": "peptide serotonyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0120296", "name": "peptide dopaminyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0120298", "name": "peptide noradrenalinyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0120299", "name": "peptide histaminyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0120300", "name": "peptide lactyltransferase (CoA-dependent) activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0120571", "name": "dihydrolipoyllysine-residue glutaryltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016417" ] } } }, { "id": "GO:0140010", "name": "D-aspartate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015556", "GO:0042943" ], "previous": [ "GO:0005310", "GO:0015556", "GO:0042943" ] } } }, { "id": "GO:0140064", "name": "peptide crotonyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0140065", "name": "peptide butyryltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747" ], "previous": [ "GO:0016410" ] } } }, { "id": "GO:0140161", "name": "monocarboxylate:sodium symporter activity", "changes": { "is_a": { "current": [ "GO:0005343", "GO:0008028" ], "previous": [ "GO:0005343", "GO:0015355" ] } } }, { "id": "GO:0140186", "name": "protein N-acyltransferase activity", "changes": { "is_a": { "current": [ "GO:0016747", "GO:0140096" ], "previous": [ "GO:0016410", "GO:0140096" ] } } }, { "id": "GO:0140443", "name": "mitochondrion-plasma membrane adaptor activity", "changes": { "is_a": { "current": [ "GO:0140177" ], "previous": [ "GO:0043495" ] } } }, { "id": "GO:0140618", "name": "ferric-chelate reductase (NADH) activity", "changes": { "is_a": { "current": [ "GO:0000293" ], "previous": [ "GO:0000293", "GO:0016723" ] } } }, { "id": "GO:0140812", "name": "orotate:monoatomic anion antiporter activity", "changes": { "is_a": { "current": [ "GO:0008028", "GO:0008509", "GO:0015297", "GO:0015355" ], "previous": [ "GO:0008509", "GO:0015297", "GO:0015355" ] } } }, { "id": "GO:0140818", "name": "mRNA 5'-triphosphate monophosphatase activity", "changes": { "is_a": { "current": [ "GO:0004651", "GO:0016462", "GO:0140098" ], "previous": [ "GO:0016462", "GO:0140098" ] } } }, { "id": "GO:0160183", "name": "autophagosome-membrane adaptor activity", "changes": { "is_a": { "current": [ "GO:0140177", "GO:0160247" ], "previous": [ "GO:0043495", "GO:0160247" ] } } }, { "id": "GO:0160190", "name": "peroxisome-mitochondrion membrane tether activity", "changes": { "is_a": { "current": [ "GO:0140177" ], "previous": [ "GO:0043495" ] } } }, { "id": "GO:0160204", "name": "mitochondrion-mitochondrion outer membrane tether activity", "changes": { "is_a": { "current": [ "GO:0140177" ], "previous": [ "GO:0043495" ] } } }, { "id": "GO:0160214", "name": "endoplasmic reticulum-plasma membrane adaptor activity", "changes": { "is_a": { "current": [ "GO:0140177" ], "previous": [ "GO:0043495" ] } } }, { "id": "GO:0170008", "name": "mRNA phosphatase activator activity", "changes": { "is_a": { "current": [ "GO:0019211" ], "previous": [ "GO:0008047" ] } } }, { "id": "GO:0170009", "name": "endoplasmic reticulum-organelle membrane tether activity", "changes": { "is_a": { "current": [ "GO:0140177" ], "previous": [ "GO:0043495" ] } } }, { "id": "GO:1901974", "name": "glycerate transmembrane transporter activity", "changes": { "is_a": { "current": [ "GO:0015144", "GO:0042879" ], "previous": [ "GO:0008028", "GO:0015144", "GO:0042879" ] } } } ], "cellular_component": [ { "id": "GO:0002102", "name": "podosome", "changes": { "is_a": { "current": [ "GO:0098858" ], "previous": [ "GO:0043232" ] }, "relationship": { "current": "N/A", "previous": [ "part_of GO:0015629" ] } } }, { "id": "GO:0032420", "name": "stereocilium", "changes": { "relationship": { "current": [ "part_of GO:0032421" ], "previous": [ "part_of GO:0032421", "part_of GO:0043226" ] } } }, { "id": "GO:0045275", "name": "respiratory chain complex III", "changes": { "is_a": { "current": [ "GO:0070069", "GO:0098803", "GO:1902495", "GO:1990204" ], "previous": [ "GO:0070069", "GO:0098803", "GO:1902495" ] } } }, { "id": "GO:0045277", "name": "respiratory chain complex IV", "changes": { "is_a": { "current": [ "GO:0070069", "GO:0098803", "GO:1902495", "GO:1990204" ], "previous": [ "GO:0070069", "GO:0098803", "GO:1902495" ] } } }, { "id": "GO:0060171", "name": "stereocilium membrane", "changes": { "relationship": { "current": [ "part_of GO:0032420" ], "previous": [ "part_of GO:0005622", "part_of GO:0032420" ] } } }, { "id": "GO:0061852", "name": "retrograde cargo receptor complex, Golgi to ER", "changes": { "is_a": { "current": [ "GO:0062137" ], "previous": [ "GO:1990351" ] } } }, { "id": "GO:0070867", "name": "mating projection tip membrane", "changes": { "relationship": { "current": [ "part_of GO:0043332", "part_of GO:0070250" ], "previous": [ "part_of GO:0043332" ] } } }, { "id": "GO:0098858", "name": "actin-based cell projection", "changes": { "relationship": { "current": [ "part_of GO:0015629" ], "previous": [ "has_part GO:0005884" ] } } }, { "id": "GO:0110103", "name": "RNA polymerase II termination complex", "changes": { "is_a": { "current": [ "GO:0140513", "GO:1903293", "GO:1905354" ], "previous": [ "GO:0140513", "GO:1905354" ] } } } ] } } }