# GORULE violations assigned by ARUK-UCL

## SUMMARY

This report generated on 2026-05-21

## Contents

[gorule-0000008](#gorule-0000008)[No annotations should be made to uninformative high level terms]{}

[gorule-0000020](#gorule-0000020)[Automatic repair of annotations to merged or obsoleted terms]{}

[gorule-0000046](#gorule-0000046)[The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.]{}

[gorule-0000065](#gorule-0000065)[Annotations to term that are candidates for obsoletion should be produce a warning]{}

## MESSAGES

###gorule-0000008

No annotations should be made to uninformative high level terms

* total: 20
#### Messages
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:101924	Slc12a2	located_in	GO:0042995	PMID:11940530	IDA		C	solute carrier family 12, member 2	Nkcc1|mBSC2|sodium/potassium/chloride cotransporters|sy-ns	protein	NCBITaxon:10090	20200120	ARUK-UCL	part_of(CL:0002605),part_of(UBERON:0000956)	MGI:MGI:101924
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:2146030	Slc2a13	located_in	GO:0031090	PMID:14749729	IDA		C	solute carrier family 2 (facilitated glucose transporter), member 13	A630029G22Rik	protein	NCBITaxon:10090	20200226	ARUK-UCL	part_of(UBERON:0000955)	MGI:MGI:2146030
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:88106	Atp1a2	located_in	GO:0042995	PMID:12458206	IDA		C	ATPase, Na+/K+ transporting, alpha 2 polypeptide	Atpa-3	protein	NCBITaxon:10090	20190917	ARUK-UCL	part_of(UBERON:0000955)	MGI:MGI:88106
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`MGI	MGI:88106	Atp1a2	located_in	GO:0042995	PMID:12805306	IDA		C	ATPase, Na+/K+ transporting, alpha 2 polypeptide	Atpa-3	protein	NCBITaxon:10090	20190917	ARUK-UCL	part_of(UBERON:0001876),part_of(UBERON:0002606)|part_of(UBERON:0004725),part_of(UBERON:0002606)	MGI:MGI:88106
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`RGD	2927	Itgb1	involved_in	GO:0030030	PMID:20091784	IMP		P	integrin subunit beta 1		protein	NCBITaxon:10116	20180521	ARUK-UCL	part_of(GO:0071318),occurs_in(CL:0000129)|part_of(GO:0071415),occurs_in(CL:0000129)	RGD:2927
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`RGD	620458	Cx3cl1	located_in	GO:0042995	PMID:11870871	IDA		C	C-X3-C motif chemokine ligand 1		protein	NCBITaxon:10116	20180605	ARUK-UCL	part_of(CL:0000127)	RGD:620458
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`RGD	621814	Slc2a13	located_in	GO:0042995	PMID:19607714	IDA		C	solute carrier family 2 member 13		protein	NCBITaxon:10116	20200225	ARUK-UCL	part_of(UBERON:0000955),part_of(UBERON:0000956)	RGD:621814
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P05023	ATP1A1	located_in	GO:0031090	PMID:19751721	IGI	UniProtKB:P05026	C	Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	protein	taxon:9606	20190917	ARUK-UCL	part_of(CL:0000746)	UniProtKB:P05023
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P05026	ATP1B1	located_in	GO:0031090	PMID:19751721	IGI	UniProtKB:P05023|UniProtKB:P13637|UniProtKB:P50993	C	Sodium/potassium-transporting ATPase subunit beta-1	ATP1B1|ATP1B	protein	taxon:9606	20190917	ARUK-UCL	part_of(CL:0000746)	UniProtKB:P05026
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P05556	ITGB1	involved_in	GO:0030030	GO_REF:0000024	ISS	UniProtKB:P49134	P	Integrin beta-1	ITGB1|FNRB|MDF2|MSK12	protein	taxon:9606	20180522	ARUK-UCL	part_of(GO:0071318),occurs_in(CL:0000129)|part_of(GO:0071415),occurs_in(CL:0000129)	UniProtKB:P05556
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P13637	ATP1A3	located_in	GO:0031090	PMID:19751721	IGI	UniProtKB:P05026	C	Sodium/potassium-transporting ATPase subunit alpha-3	ATP1A3	protein	taxon:9606	20190917	ARUK-UCL	part_of(CL:0000746)	UniProtKB:P13637
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P50993	ATP1A2	located_in	GO:0031090	PMID:19751721	IGI	UniProtKB:P05026	C	Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2|KIAA0778	protein	taxon:9606	20190917	ARUK-UCL	part_of(CL:0000746)	UniProtKB:P50993
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P50993	ATP1A2	located_in	GO:0042995	GO_REF:0000024	ISS	UniProtKB:Q6PIE5	C	Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2|KIAA0778	protein	taxon:9606	20190917	ARUK-UCL	part_of(UBERON:0000955)	UniProtKB:P50993
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P50993	ATP1A2	located_in	GO:0042995	GO_REF:0000024	ISS	UniProtKB:Q6PIE5	C	Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2|KIAA0778	protein	taxon:9606	20190917	ARUK-UCL	part_of(UBERON:0001876),part_of(UBERON:0002606)|part_of(UBERON:0004725),part_of(UBERON:0002606)	UniProtKB:P50993
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P55011	SLC12A2	located_in	GO:0042995	GO_REF:0000024	ISS	UniProtKB:P55012	C	Solute carrier family 12 member 2	SLC12A2|NKCC1	protein	taxon:9606	20200120	ARUK-UCL	part_of(CL:0002605),part_of(UBERON:0000956)	UniProtKB:P55011
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	P78423	CX3CL1	located_in	GO:0042995	GO_REF:0000024	ISS	UniProtKB:O55145	C	Fractalkine	CX3CL1|FKN|NTT|SCYD1|A-152E5.2	protein	taxon:9606	20180605	ARUK-UCL	part_of(CL:0000127)	UniProtKB:P78423
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	Q93084	ATP2A3	located_in	GO:0031090	PMID:15028735	IDA		C	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	ATP2A3	protein	taxon:9606	20191001	ARUK-UCL		UniProtKB:Q93084
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	Q96QE2	SLC2A13	located_in	GO:0031090	GO_REF:0000024	ISS	UniProtKB:Q3UHK1	C	Proton myo-inositol cotransporter	SLC2A13	protein	taxon:9606	20200226	ARUK-UCL	part_of(UBERON:0000955)	UniProtKB:Q96QE2
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	Q96QE2	SLC2A13	located_in	GO:0042995	PMID:19607714	IDA		C	Proton myo-inositol cotransporter	SLC2A13	protein	taxon:9606	20200225	ARUK-UCL	part_of(UBERON:0000955),part_of(UBERON:0002421)|part_of(UBERON:0000955),part_of(UBERON:0010225)|part_of(UBERON:0000955),part_of(UBERON:0000956)	UniProtKB:Q96QE2
`
* WARNING - Violates GO Rule:GORULE:0000008: No annotations should be made to uninformatively high level terms--`UniProtKB	Q9H244	P2RY12	involved_in	GO:0030030	GO_REF:0000024	ISS	UniProtKB:Q9EPX4	P	P2Y purinoceptor 12	P2RY12|HORK3	protein	taxon:9606	20180522	ARUK-UCL	part_of(GO:0071318),occurs_in(CL:0000129)|part_of(GO:0071415),occurs_in(CL:0000129)	UniProtKB:Q9H244
`

###gorule-0000020

Automatic repair of annotations to merged or obsoleted terms

* total: 4
#### Messages
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`MGI	MGI:1333817	Slc22a3	enables	GO:0005326	PMID:18513366	IMP		F	solute carrier family 22 (organic cation transporter), member 3	EMT|Oct3|Orct3	protein	NCBITaxon:10090	20200604	ARUK-UCL	occurs_in(UBERON:0000988),has_input(CHEBI:28790),part_of(GO:0006837)|occurs_in(UBERON:0002264),has_input(CHEBI:18243),part_of(GO:0015872)|occurs_in(UBERON:0001851),occurs_in(UBERON:0000955),has_input(CHEBI:18243),part_of(GO:0015872)|occurs_in(UBERON:0002435),has_input(CHEBI:18243),part_of(GO:0015872)|occurs_in(UBERON:0000988),has_input(CHEBI:18243),part_of(GO:0015872)|occurs_in(UBERON:0001851),occurs_in(UBERON:0000955),has_input(CHEBI:18295),part_of(GO:0051608)	MGI:MGI:1333817
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	O75751	SLC22A3	involved_in	GO:0051615	PMID:23505051	IMP		P	Solute carrier family 22 member 3	SLC22A3|EMTH|OCT3	protein	taxon:9606	20200430	ARUK-UCL	occurs_in(CL:0000127),part_of(GO:0015844),part_of(GO:0006836)	UniProtKB:O75751
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	Q7RTT9	SLC29A4	involved_in	GO:0051615	PMID:23505051	IMP		P	Equilibrative nucleoside transporter 4	SLC29A4|ENT4|PMAT|PSEC0113	protein	taxon:9606	20200430	ARUK-UCL	occurs_in(CL:0000127),part_of(GO:0015844),part_of(GO:0006836)	UniProtKB:Q7RTT9
`
* ERROR - Obsolete class with no replacement:Violates GORULE:0000020--`UniProtKB	P60709	ACTB	involved_in	GO:1903076	PMID:18331289	IMP		P	Actin, cytoplasmic 1	ACTB	protein	taxon:9606	20180515	ARUK-UCL	has_input(UniProtKB:P23975),regulates(GO:0015874)	UniProtKB:P60709
`

###gorule-0000046

The ‘with’ field (GAF column 8) must be the same as the gene product (GAF column 2) when annotating to ‘self-binding’ terms.

* total: 13
#### Messages
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:1196458	Scarb2	enables	GO:0042803	PMID:29199275	IPI	UniProtKB:O35114	F	scavenger receptor class B, member 2	9330185J12Rik|Cd36l2|LGP85|LIMP II|LIMP-2	protein	NCBITaxon:10090	20181031	ARUK-UCL		MGI:MGI:1196458
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:894311	Pirb	enables	GO:0042803	PMID:24052308	IPI	UniProtKB:P97484	F	paired Ig-like receptor B	Gp91|Lilrb3	protein	NCBITaxon:10090	20230314	ARUK-UCL	causally_upstream_of(GO:0001540)	MGI:MGI:894311
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`MGI	MGI:97275	Myod1	enables	GO:0042803	PMID:10652346	IPI	UniProtKB:P10085	F	myogenic differentiation 1	MYF3|MyoD|Myod-1|bHLHc1	protein	NCBITaxon:10090	20230314	ARUK-UCL		MGI:MGI:97275
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	enables	GO:0042803	PMID:15447668	IPI	UniProtKB:P05067-PRO_0000000092	F	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000092
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	enables	GO:0042803	PMID:15447668	IPI	UniProtKB:P05067-PRO_0000000093	F	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000093
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	enables	GO:0042803	PMID:18568035	IPI	UniProtKB:P05067-PRO_0000000092	F	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20170213	ARUK-UCL		UniProtKB:P05067-PRO_0000000092
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	enables	GO:0042803	PMID:22179788	IPI	UniProtKB:P05067-PRO_0000000093	F	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000093
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	enables	GO:0042803	PMID:23386614	IPI	UniProtKB:P05067-PRO_0000000092	F	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000092
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	involved_in	GO:0051260	PMID:15447668	IPI	UniProtKB:P05067-PRO_0000000092	P	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000092
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	involved_in	GO:0051260	PMID:15447668	IPI	UniProtKB:P05067-PRO_0000000093	P	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL	has_input(UniProtKB:P05067-PRO_0000000093)	UniProtKB:P05067-PRO_0000000093
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	involved_in	GO:0051260	PMID:18602473	IPI	UniProtKB:P05067-PRO_0000000093	P	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL		UniProtKB:P05067-PRO_0000000093
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P05067	APP	involved_in	GO:0051260	PMID:23386614	IPI	UniProtKB:P05067-PRO_0000000092	P	Amyloid-beta precursor protein	APP|A4|AD1	protein	taxon:9606	20230314	ARUK-UCL	has_input(UniProtKB:P05067)	UniProtKB:P05067-PRO_0000000092
`
* WARNING - Violates GO Rule:GORULE:0000046: The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms--`UniProtKB	P10636	MAPT	involved_in	GO:0051260	PMID:26704708	IPI	UniProtKB:P10636-8	P	Microtubule-associated protein tau	MAPT|MAPTL|MTBT1|TAU	protein	taxon:9606	20230314	ARUK-UCL	happens_during(UBERON:0000112),happens_during(GO:0018105),occurs_in(UBERON:0002421),regulates(GO:0007611)|happens_during(UBERON:0018241),happens_during(GO:0018105),occurs_in(UBERON:0002421),regulates(GO:0007611)	UniProtKB:P10636-8
`

###gorule-0000065

Annotations to term that are candidates for obsoletion should be produce a warning

* total: 1
#### Messages
* WARNING - Violates GO Rule:GORULE:0000065: Annotations to term that are candidates for obsoletion should be removed--`UniProtKB	Q7Z5W3	BCDIN3D	involved_in	GO:0001510	PMID:33664453	IDA		P	RNA 5'-monophosphate methyltransferase	BCDIN3D	protein	taxon:9606	20220322	ARUK-UCL	has_output(RNAcentral:URS00002F8148_9606),has_output(RNAcentral:URS00003B7674_9606),part_of(GO:0031054)	UniProtKB:Q7Z5W3
`