GO:0005634 nucleus AnnotationPropagation C GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0000964 mitochondrial RNA 5'-end processing IBA GO:0015887 pantothenate transmembrane transport AnnotationPropagation P GO:0015233 pantothenate transmembrane transporter activity IBA GO:0032147 activation of protein kinase activity AnnotationPropagation P GO:0030295 protein kinase activator activity IBA GO:0006259 DNA metabolic process AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0019887 protein kinase regulator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0032543 mitochondrial translation IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000026 alpha-1,2-mannosyltransferase activity IBA GO:0000165 MAPK cascade AnnotationPropagation P GO:0004708 MAP kinase kinase activity IBA GO:0034414 tRNA 3'-trailer cleavage, endonucleolytic AnnotationPropagation P GO:0042781 3'-tRNA processing endoribonuclease activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0045039 protein insertion into mitochondrial inner membrane IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0043138 3'-5' DNA helicase activity IBA GO:0051170 import into nucleus AnnotationPropagation P GO:0061608 nuclear import signal receptor activity IBA GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation AnnotationPropagation P GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IBA GO:0006412 translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006413 translational initiation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0006412 translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006413 translational initiation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000009 alpha-1,6-mannosyltransferase activity IBA GO:0016571 histone methylation AnnotationPropagation P GO:0046975 histone methyltransferase activity (H3-K36 specific) IBA GO:0005829 cytosol AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0006096 glycolytic process AnnotationPropagation P GO:0004743 pyruvate kinase activity IBA GO:0006481 C-terminal protein methylation AnnotationPropagation P GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity IBA GO:1903830 magnesium ion transmembrane transport AnnotationPropagation P GO:0015095 magnesium ion transmembrane transporter activity IBA GO:0006412 translation AnnotationPropagation P GO:0016150 translation release factor activity, codon nonspecific IBA GO:0006415 translational termination AnnotationPropagation P GO:0016150 translation release factor activity, codon nonspecific IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0016150 translation release factor activity, codon nonspecific IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0035352 NAD transmembrane transport AnnotationPropagation P GO:0051724 NAD transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0009107 lipoate biosynthetic process AnnotationPropagation P GO:0016992 lipoate synthase activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0032543 mitochondrial translation IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003700 DNA-binding transcription factor activity IBA GO:0006355 regulation of DNA-templated transcription AnnotationPropagation P GO:0003700 DNA-binding transcription factor activity IBA GO:1990570 GDP-mannose transmembrane transport AnnotationPropagation P GO:0005458 GDP-mannose transmembrane transporter activity IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0008324 cation transmembrane transporter activity IBA GO:0035350 FAD transmembrane transport AnnotationPropagation P GO:0015230 FAD transmembrane transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0006264 mitochondrial DNA replication IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0005351 carbohydrate:proton symporter activity IBA GO:0034219 carbohydrate transmembrane transport AnnotationPropagation P GO:0005351 carbohydrate:proton symporter activity IBA GO:0002943 tRNA dihydrouridine synthesis AnnotationPropagation P GO:0017150 tRNA dihydrouridine synthase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015385 sodium:proton antiporter activity IBA GO:0035725 sodium ion transmembrane transport AnnotationPropagation P GO:0015385 sodium:proton antiporter activity IBA GO:0000165 MAPK cascade AnnotationPropagation P GO:0004708 MAP kinase kinase activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0008324 cation transmembrane transporter activity IBA GO:0010951 negative regulation of endopeptidase activity AnnotationPropagation P GO:0004866 endopeptidase inhibitor activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly IBA GO:0015918 sterol transport AnnotationPropagation P GO:0015248 sterol transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0006390 mitochondrial transcription IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0001510 RNA methylation AnnotationPropagation P GO:0008173 RNA methyltransferase activity IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0000175 3'-5'-exoribonuclease activity IBA GO:0015813 L-glutamate transmembrane transport AnnotationPropagation P GO:0005313 L-glutamate transmembrane transporter activity IBA GO:0006412 translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006413 translational initiation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0008175 tRNA methyltransferase activity IBA GO:0035434 copper ion transmembrane transport AnnotationPropagation P GO:0005375 copper ion transmembrane transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0034982 mitochondrial protein processing IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0009378 four-way junction helicase activity IBA GO:0006479 protein methylation AnnotationPropagation P GO:0016279 protein-lysine N-methyltransferase activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015295 solute:proton symporter activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0034204 lipid translocation AnnotationPropagation P GO:0140326 ATPase-coupled intramembrane lipid transporter activity IBA GO:0000165 MAPK cascade AnnotationPropagation P GO:0004707 MAP kinase activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0008409 5'-3' exonuclease activity IBA GO:0006366 transcription by RNA polymerase II AnnotationPropagation P GO:0016251 RNA polymerase II general transcription initiation factor activity IBA GO:0005829 cytosol AnnotationPropagation C GO:0006895 Golgi to endosome transport IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0030695 GTPase regulator activity IBA GO:0015914 phospholipid transport AnnotationPropagation P GO:0008526 phosphatidylinositol transfer activity IBA GO:0120009 intermembrane lipid transfer AnnotationPropagation P GO:0008526 phosphatidylinositol transfer activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0016428 tRNA (cytosine-5-)-methyltransferase activity IBA GO:1901800 positive regulation of proteasomal protein catabolic process AnnotationPropagation P GO:0036402 proteasome-activating activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0008175 tRNA methyltransferase activity IBA GO:0003333 amino acid transmembrane transport AnnotationPropagation P GO:0015171 amino acid transmembrane transporter activity IBA GO:0001188 RNA polymerase I preinitiation complex assembly AnnotationPropagation P GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0045040 protein insertion into mitochondrial outer membrane IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0042776 proton motive force-driven mitochondrial ATP synthesis IBA GO:1990822 basic amino acid transmembrane transport AnnotationPropagation P GO:0015174 basic amino acid transmembrane transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly IBA GO:0071577 zinc ion transmembrane transport AnnotationPropagation P GO:0005385 zinc ion transmembrane transporter activity IBA GO:0006259 DNA metabolic process AnnotationPropagation P GO:0008296 3'-5'-exodeoxyribonuclease activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0008296 3'-5'-exodeoxyribonuclease activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0005829 cytosol AnnotationPropagation C GO:0006895 Golgi to endosome transport IBA GO:0098869 cellular oxidant detoxification AnnotationPropagation P GO:0032542 sulfiredoxin activity IBA GO:0032147 activation of protein kinase activity AnnotationPropagation P GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity AnnotationPropagation P GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity IBA GO:0044322 endoplasmic reticulum quality control compartment AnnotationPropagation C GO:1904380 endoplasmic reticulum mannose trimming IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0002943 tRNA dihydrouridine synthesis AnnotationPropagation P GO:0017150 tRNA dihydrouridine synthase activity IBA GO:0051170 import into nucleus AnnotationPropagation P GO:0061608 nuclear import signal receptor activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0004527 exonuclease activity IBA GO:0005829 cytosol AnnotationPropagation C GO:0006895 Golgi to endosome transport IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015295 solute:proton symporter activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0015205 nucleobase transmembrane transporter activity IBA GO:0015851 nucleobase transport AnnotationPropagation P GO:0015205 nucleobase transmembrane transporter activity IBA GO:0005829 cytosol AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi IBA GO:0071897 DNA biosynthetic process AnnotationPropagation P GO:0003887 DNA-directed DNA polymerase activity IBA GO:0046835 carbohydrate phosphorylation AnnotationPropagation P GO:0004856 xylulokinase activity IBA GO:0071934 thiamine transmembrane transport AnnotationPropagation P GO:0015234 thiamine transmembrane transporter activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015295 solute:proton symporter activity IBA GO:0035672 oligopeptide transmembrane transport AnnotationPropagation P GO:0035673 oligopeptide transmembrane transporter activity IBA GO:0006278 RNA-templated DNA biosynthetic process AnnotationPropagation P GO:0003721 telomerase RNA reverse transcriptase activity IBA GO:0003333 amino acid transmembrane transport AnnotationPropagation P GO:0015171 amino acid transmembrane transporter activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0046961 proton-transporting ATPase activity, rotational mechanism IBA GO:0061727 methylglyoxal catabolic process to lactate AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0019249 lactate biosynthetic process AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0006479 protein methylation AnnotationPropagation P GO:0035243 protein-arginine omega-N symmetric methyltransferase activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0009019 tRNA (guanine-N1-)-methyltransferase activity IBA GO:0006412 translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006413 translational initiation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006412 translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006413 translational initiation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003743 translation initiation factor activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0032543 mitochondrial translation IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000026 alpha-1,2-mannosyltransferase activity IBA GO:0046835 carbohydrate phosphorylation AnnotationPropagation P GO:0003873 6-phosphofructo-2-kinase activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0045893 positive regulation of DNA-templated transcription AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005093 Rab GDP-dissociation inhibitor activity IBA GO:0032147 activation of protein kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0071902 positive regulation of protein serine/threonine kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0000175 3'-5'-exoribonuclease activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0032543 mitochondrial translation IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0061727 methylglyoxal catabolic process to lactate AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0019249 lactate biosynthetic process AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0030001 metal ion transport AnnotationPropagation P GO:0046873 metal ion transmembrane transporter activity IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0046873 metal ion transmembrane transporter activity IBA GO:0071918 urea transmembrane transport AnnotationPropagation P GO:0015204 urea transmembrane transporter activity IBA GO:0006259 DNA metabolic process AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0046961 proton-transporting ATPase activity, rotational mechanism IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0005227 calcium activated cation channel activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0005794 Golgi apparatus AnnotationPropagation C GO:0032468 Golgi calcium ion homeostasis IBA GO:0034755 iron ion transmembrane transport AnnotationPropagation P GO:0005381 iron ion transmembrane transporter activity IBA GO:0000165 MAPK cascade AnnotationPropagation P GO:0004707 MAP kinase activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0052735 tRNA (cytosine-3-)-methyltransferase activity IBA GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic AnnotationPropagation P GO:0004521 endoribonuclease activity IBA GO:1901679 nucleotide transmembrane transport AnnotationPropagation P GO:0005347 ATP transmembrane transporter activity IBA GO:0015867 ATP transport AnnotationPropagation P GO:0005347 ATP transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0005347 ATP transmembrane transporter activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0045893 positive regulation of DNA-templated transcription AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0003333 amino acid transmembrane transport AnnotationPropagation P GO:0015171 amino acid transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA GO:0098869 cellular oxidant detoxification AnnotationPropagation P GO:0004601 peroxidase activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0070042 rRNA (uridine-N3-)-methyltransferase activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0046961 proton-transporting ATPase activity, rotational mechanism IBA GO:0005829 cytosol AnnotationPropagation C GO:0006895 Golgi to endosome transport IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0045040 protein insertion into mitochondrial outer membrane IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0042626 ATPase-coupled transmembrane transporter activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0071897 DNA biosynthetic process AnnotationPropagation P GO:0003887 DNA-directed DNA polymerase activity IBA GO:1903790 guanine nucleotide transmembrane transport AnnotationPropagation P GO:0001409 guanine nucleotide transmembrane transporter activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0030696 tRNA (m5U54) methyltransferase activity IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0043138 3'-5' DNA helicase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process AnnotationPropagation P GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IBA GO:0061727 methylglyoxal catabolic process to lactate AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0019249 lactate biosynthetic process AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0005634 nucleus AnnotationPropagation C GO:1902969 mitotic DNA replication IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0004519 endonuclease activity IBA GO:0002943 tRNA dihydrouridine synthesis AnnotationPropagation P GO:0017150 tRNA dihydrouridine synthase activity IBA GO:0005634 nucleus AnnotationPropagation C GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0007007 inner mitochondrial membrane organization IBA GO:0032147 activation of protein kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0071902 positive regulation of protein serine/threonine kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000030 mannosyltransferase activity IBA GO:0099116 tRNA 5'-end processing AnnotationPropagation P GO:0008193 tRNA guanylyltransferase activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000030 mannosyltransferase activity IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0005227 calcium activated cation channel activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0032147 activation of protein kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0071902 positive regulation of protein serine/threonine kinase activity AnnotationPropagation P GO:0043539 protein serine/threonine kinase activator activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0016428 tRNA (cytosine-5-)-methyltransferase activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0004527 exonuclease activity IBA GO:0046940 nucleoside monophosphate phosphorylation AnnotationPropagation P GO:0004017 adenylate kinase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0090150 establishment of protein localization to membrane AnnotationPropagation P GO:0032977 membrane insertase activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0008175 tRNA methyltransferase activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0042626 ATPase-coupled transmembrane transporter activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0006479 protein methylation AnnotationPropagation P GO:0008276 protein methyltransferase activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0042823 pyridoxal phosphate biosynthetic process AnnotationPropagation P GO:0004733 pyridoxamine-phosphate oxidase activity IBA GO:0030488 tRNA methylation AnnotationPropagation P GO:0008175 tRNA methyltransferase activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0030970 retrograde protein transport, ER to cytosol IBA GO:0016192 vesicle-mediated transport AnnotationPropagation P GO:0035615 clathrin adaptor activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005094 Rho GDP-dissociation inhibitor activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0000175 3'-5'-exoribonuclease activity IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005085 guanyl-nucleotide exchange factor activity IBA GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic AnnotationPropagation P GO:0004521 endoribonuclease activity IBA GO:0007010 cytoskeleton organization AnnotationPropagation P GO:0005200 structural constituent of cytoskeleton IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0061025 membrane fusion AnnotationPropagation P GO:0005484 SNAP receptor activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0008409 5'-3' exonuclease activity IBA GO:0006412 translation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0006414 translational elongation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015385 sodium:proton antiporter activity IBA GO:0035725 sodium ion transmembrane transport AnnotationPropagation P GO:0015385 sodium:proton antiporter activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015299 solute:proton antiporter activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0071577 zinc ion transmembrane transport AnnotationPropagation P GO:0005385 zinc ion transmembrane transporter activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000026 alpha-1,2-mannosyltransferase activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0070124 mitochondrial translational initiation IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0045893 positive regulation of DNA-templated transcription AnnotationPropagation P GO:0003713 transcription coactivator activity IBA GO:0006357 regulation of transcription by RNA polymerase II AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA GO:0006412 translation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0006414 translational elongation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0006417 regulation of translation AnnotationPropagation P GO:0003746 translation elongation factor activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0015297 antiporter activity IBA GO:0001510 RNA methylation AnnotationPropagation P GO:0008173 RNA methyltransferase activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003700 DNA-binding transcription factor activity IBA GO:0006355 regulation of DNA-templated transcription AnnotationPropagation P GO:0003700 DNA-binding transcription factor activity IBA GO:0051170 import into nucleus AnnotationPropagation P GO:0061608 nuclear import signal receptor activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0034551 mitochondrial respiratory chain complex III assembly IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0003678 DNA helicase activity IBA GO:0071806 protein transmembrane transport AnnotationPropagation P GO:0008320 protein transmembrane transporter activity IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0000175 3'-5'-exoribonuclease activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0005634 nucleus AnnotationPropagation C GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity IBA GO:0006457 protein folding AnnotationPropagation P GO:0044183 protein folding chaperone IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005085 guanyl-nucleotide exchange factor activity IBA GO:0005773 vacuole AnnotationPropagation C GO:0006624 vacuolar protein processing IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0016433 rRNA (adenine) methyltransferase activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005085 guanyl-nucleotide exchange factor activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0034551 mitochondrial respiratory chain complex III assembly IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0042626 ATPase-coupled transmembrane transporter activity IBA GO:0000160 phosphorelay signal transduction system AnnotationPropagation P GO:0000156 phosphorelay response regulator activity IBA GO:0016571 histone methylation AnnotationPropagation P GO:0042054 histone methyltransferase activity IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0043138 3'-5' DNA helicase activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0006693 prostaglandin metabolic process AnnotationPropagation P GO:0036132 13-prostaglandin reductase activity IBA GO:0015807 L-amino acid transport AnnotationPropagation P GO:0015187 glycine transmembrane transporter activity IBA GO:0015816 glycine transport AnnotationPropagation P GO:0015187 glycine transmembrane transporter activity IBA GO:0098655 cation transmembrane transport AnnotationPropagation P GO:0015187 glycine transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0015187 glycine transmembrane transporter activity IBA GO:1902475 L-alpha-amino acid transmembrane transport AnnotationPropagation P GO:0015187 glycine transmembrane transporter activity IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0070037 rRNA (pseudouridine) methyltransferase activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000030 mannosyltransferase activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0061727 methylglyoxal catabolic process to lactate AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0019249 lactate biosynthetic process AnnotationPropagation P GO:0019172 glyoxalase III activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0061025 membrane fusion AnnotationPropagation P GO:0005484 SNAP receptor activity IBA GO:0016571 histone methylation AnnotationPropagation P GO:0018024 histone-lysine N-methyltransferase activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0003333 amino acid transmembrane transport AnnotationPropagation P GO:0015171 amino acid transmembrane transporter activity IBA GO:0005773 vacuole AnnotationPropagation C GO:0007039 protein catabolic process in the vacuole IBA GO:0035442 dipeptide transmembrane transport AnnotationPropagation P GO:0071916 dipeptide transmembrane transporter activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005085 guanyl-nucleotide exchange factor activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0042407 cristae formation IBA GO:0019430 removal of superoxide radicals AnnotationPropagation P GO:0004784 superoxide dismutase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0000316 sulfite transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0070125 mitochondrial translational elongation IBA GO:0046854 phosphatidylinositol phosphate biosynthetic process AnnotationPropagation P GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0032543 mitochondrial translation IBA GO:1902358 sulfate transmembrane transport AnnotationPropagation P GO:0015116 sulfate transmembrane transporter activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0034450 ubiquitin-ubiquitin ligase activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0005351 carbohydrate:proton symporter activity IBA GO:0034219 carbohydrate transmembrane transport AnnotationPropagation P GO:0005351 carbohydrate:proton symporter activity IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0071806 protein transmembrane transport AnnotationPropagation P GO:0008320 protein transmembrane transporter activity IBA GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic AnnotationPropagation P GO:0000213 tRNA-intron endonuclease activity IBA GO:0022900 electron transport chain AnnotationPropagation P GO:0009055 electron transfer activity IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0004534 5'-3' exoribonuclease activity IBA GO:0016571 histone methylation AnnotationPropagation P GO:0008469 histone-arginine N-methyltransferase activity IBA GO:0006354 DNA-templated transcription elongation AnnotationPropagation P GO:0003712 transcription coregulator activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0006913 nucleocytoplasmic transport AnnotationPropagation P GO:0017056 structural constituent of nuclear pore IBA GO:0007186 G protein-coupled receptor signaling pathway AnnotationPropagation P GO:0004930 G protein-coupled receptor activity IBA GO:0070588 calcium ion transmembrane transport AnnotationPropagation P GO:0015369 calcium:proton antiporter activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P GO:0015369 calcium:proton antiporter activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0004527 exonuclease activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0006457 protein folding AnnotationPropagation P GO:0044183 protein folding chaperone IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005085 guanyl-nucleotide exchange factor activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000030 mannosyltransferase activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0033617 mitochondrial cytochrome c oxidase assembly IBA GO:0031167 rRNA methylation AnnotationPropagation P GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA GO:0015807 L-amino acid transport AnnotationPropagation P GO:0015179 L-amino acid transmembrane transporter activity IBA GO:1902475 L-alpha-amino acid transmembrane transport AnnotationPropagation P GO:0015179 L-amino acid transmembrane transporter activity IBA GO:1901800 positive regulation of proteasomal protein catabolic process AnnotationPropagation P GO:0036402 proteasome-activating activity IBA GO:0016567 protein ubiquitination AnnotationPropagation P GO:0061630 ubiquitin protein ligase activity IBA GO:0032508 DNA duplex unwinding AnnotationPropagation P GO:0043139 5'-3' DNA helicase activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0008409 5'-3' exonuclease activity IBA GO:0072488 ammonium transmembrane transport AnnotationPropagation P GO:0008519 ammonium transmembrane transporter activity IBA GO:0034204 lipid translocation AnnotationPropagation P GO:0140326 ATPase-coupled intramembrane lipid transporter activity IBA GO:0006259 DNA metabolic process AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:0090305 nucleic acid phosphodiester bond hydrolysis AnnotationPropagation P GO:0017108 5'-flap endonuclease activity IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0034551 mitochondrial respiratory chain complex III assembly IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0004535 poly(A)-specific ribonuclease activity IBA GO:0007010 cytoskeleton organization AnnotationPropagation P GO:0005200 structural constituent of cytoskeleton IBA GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic AnnotationPropagation P GO:0000175 3'-5'-exoribonuclease activity IBA GO:1901962 S-adenosyl-L-methionine transmembrane transport AnnotationPropagation P GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity IBA GO:0016192 vesicle-mediated transport AnnotationPropagation P GO:0035615 clathrin adaptor activity IBA GO:0015746 citrate transport AnnotationPropagation P GO:0071913 citrate secondary active transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0071913 citrate secondary active transmembrane transporter activity IBA GO:0035674 tricarboxylic acid transmembrane transport AnnotationPropagation P GO:0071913 citrate secondary active transmembrane transporter activity IBA GO:0055085 transmembrane transport AnnotationPropagation P GO:0022857 transmembrane transporter activity IBA GO:0005737 cytoplasm AnnotationPropagation C GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport IBA GO:0000316 sulfite transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0000316 sulfite transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0098656 anion transmembrane transport AnnotationPropagation P GO:0000319 sulfite transmembrane transporter activity IBA GO:0050790 regulation of catalytic activity AnnotationPropagation P GO:0005096 GTPase activator activity IBA GO:0097502 mannosylation AnnotationPropagation P GO:0000030 mannosyltransferase activity IBA GO:0005829 cytosol AnnotationPropagation C GO:0042147 retrograde transport, endosome to Golgi IBA GO:0005739 mitochondrion AnnotationPropagation C GO:0034553 mitochondrial respiratory chain complex II assembly IBA GO:0071805 potassium ion transmembrane transport AnnotationPropagation P GO:0140107 high-affinity potassium ion transmembrane transporter activity IBA GO:0035672 oligopeptide transmembrane transport AnnotationPropagation P GO:0035673 oligopeptide transmembrane transporter activity IBA