goslim chembl.owl
type: Ontology
version IRI: goslim chembl.owl
version info: 2025-12-29

definition
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

has ontology root term
type: AnnotationProperty
database_cross_reference: IAO:0000700
has_obo_namespace: external
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term

term replaced by
type: AnnotationProperty

chebi ph7 3
type: AnnotationProperty
comment: Rhea list of ChEBI terms representing the major species at pH 7.3.
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck obsoletion candidate
type: AnnotationProperty
comment: Terms planned for obsoletion
sub property of: subset_property

goslim agr
type: AnnotationProperty
comment: AGR slim
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim chembl
type: AnnotationProperty
comment: ChEMBL protein targets summary
sub property of: subset_property

goslim drosophila
type: AnnotationProperty
comment: Drosophila GO slim
sub property of: subset_property

goslim euk cellular processes ribbon
type: AnnotationProperty
comment: GO ribbon for eukaroytic cellular processes
sub property of: subset_property

goslim flybase ribbon
type: AnnotationProperty
comment: Insecta GO ribbon slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim mouse
type: AnnotationProperty
comment: Mouse GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim plant ribbon
type: AnnotationProperty
comment: Plant GO ribbon
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim prokaryote
type: AnnotationProperty
comment: GO subset for prokaryotes
sub property of: subset_property

goslim prokaryote ribbon
type: AnnotationProperty
comment: Prokaryote GO ribbon slim
sub property of: subset_property

goslim synapse
type: AnnotationProperty
comment: synapse GO slim
sub property of: subset_property

goslim virus
type: AnnotationProperty
comment: GO subset for viruses
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

label approved by the SynGO project
type: AnnotationProperty
sub property of: synonym_type_property

Systematic synonym
type: AnnotationProperty
has_scope: has_exact_synonym
sub property of: synonym_type_property

subset_property
type: AnnotationProperty

synonym_type_property
type: AnnotationProperty

consider
type: AnnotationProperty

created by
type: AnnotationProperty

creation date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

id
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part of
type: ObjectProperty
inverse of: has part
type: TransitiveProperty
database_cross_reference: BFO:0000050
has_obo_namespace: external
id: part_of
shorthand: part_of

has part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
has_obo_namespace: external
id: has_part
shorthand: has_part

occurs in
type: ObjectProperty
property chain axiom: part of
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
shorthand: occurs_in

starts during
type: ObjectProperty
database_cross_reference: RO:0002091
has_obo_namespace: external
id: starts_during
shorthand: starts_during

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
database_cross_reference: RO:0002092
has_obo_namespace: external
id: happens_during
shorthand: happens_during

ends during
type: ObjectProperty
database_cross_reference: RO:0002093
has_obo_namespace: external
id: ends_during
shorthand: ends_during

regulates
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
shorthand: regulates

negatively regulates
type: ObjectProperty
sub property of: regulates
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: regulates
property chain axiom: negatively regulates
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
shorthand: positively_regulates

SNARE binding
type: Class
subclass of: protein binding
definition: Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
database_cross_reference: Reactome:R-HSA-210426
database_cross_reference: Reactome:R-HSA-210430
database_cross_reference: Reactome:R-HSA-265166
database_cross_reference: Reactome:R-HSA-372505
database_cross_reference: Reactome:R-HSA-372529
database_cross_reference: Reactome:R-HSA-374899
database_cross_reference: Reactome:R-HSA-374922
database_cross_reference: Reactome:R-HSA-376357
database_cross_reference: Reactome:R-HSA-376364
database_cross_reference: Reactome:R-HSA-376369
database_cross_reference: Reactome:R-HSA-380574
database_cross_reference: Reactome:R-HSA-380869
database_cross_reference: Reactome:R-HSA-380901
database_cross_reference: Reactome:R-HSA-380905
database_cross_reference: Reactome:R-HSA-888589
database_cross_reference: Reactome:R-HSA-9023173
database_cross_reference: Reactome:R-HSA-917744
has_exact_synonym: SNAP receptor binding
has_obo_namespace: molecular_function
id: GO:0000149
in_subset: goslim chembl

Release of acetylcholine at the synapse
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-372529

Release of noradrenaline at the synapse
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-374899

Noradrenalin synaptic vesicle docking and priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-374922

Vamp7 associated Lysosome to Plasma membrane transport
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376357

Vamp8 associated secretory vesicle to plasma membrane transport
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376364

Vamp2 associated secretory vesicle to plasma membrane transport
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376369

Dopamine synaptic vesicle docking and priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380574

Release of docked dopamine loaded synaptic vesicle
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380869

Release of docked serotonin loaded synaptic vesicle
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380901

Serotonin loaded synaptic vesicle docking and priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380905

Release of GABA at the synapse
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-888589

Insulin secretory granule docks at the plasma membrane
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023173

GABA loaded synaptic vesicle Docking and Priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-917744

Axiom
annotated source: SNARE binding
annotated property: definition
annotated target: Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
database_cross_reference: PMID:12642621

Glutamate synaptic vesicle docking and priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-210426

Release of L-Glutamate at the synapse
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-210430

Exocytosis of Insulin
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-265166

Acetylcholine synaptic vesicle docking and priming
type: Axiom
annotated source: SNARE binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-372505

nucleotide binding
type: Class
subclass of: molecular_function
definition: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
has_obo_namespace: molecular_function
id: GO:0000166
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: nucleotide binding
annotated property: definition
annotated target: Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198547684

tRNA 2'-phosphotransferase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0008665
has_broad_synonym: 2'-phosphotransferase activity
database_cross_reference: EC:2.7.1.160
database_cross_reference: MetaCyc:2.7.1.160-RXN
database_cross_reference: RHEA:23324
has_narrow_synonym: yeast 2'-phosphotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
has_related_synonym: 2'-phospho-tRNA:NAD+ phosphotransferase activity
has_related_synonym: Tpt1
has_related_synonym: Tpt1p
id: GO:0000215
in_subset: goslim chembl

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.
database_cross_reference: EC:2.7.1.160
database_cross_reference: PMID:9148937

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: has_narrow_synonym
annotated target: yeast 2'-phosphotransferase activity
database_cross_reference: EC:2.7.1.160

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: has_related_synonym
annotated target: 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity
database_cross_reference: EC:2.7.1.160

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: has_related_synonym
annotated target: 2'-phospho-tRNA:NAD+ phosphotransferase activity
database_cross_reference: EC:2.7.1.160

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: has_related_synonym
annotated target: Tpt1
database_cross_reference: EC:2.7.1.160

Axiom
annotated source: tRNA 2'-phosphotransferase activity
annotated property: has_related_synonym
annotated target: Tpt1p
database_cross_reference: EC:2.7.1.160

nuclear chromosome
type: Class
equivalent class: Class
  intersection of: chromosome
  intersection of: Restriction
    on property: part of
    some values from: nucleus
subclass of: chromosome
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
has_narrow_synonym: nuclear interphase chromosome
has_obo_namespace: cellular_component
id: GO:0000228
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: nuclear chromosome
annotated property: definition
annotated target: A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah

mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: cell cycle
  intersection of: Restriction
    on property: has part
    some values from: mitotic nuclear division
subclass of: cell cycle
subclass of: Restriction
  on property: has part
  some values from: mitotic nuclear division
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
has_alternative_id: GO:0007067
database_cross_reference: Reactome:R-HSA-69278
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
id: GO:0000278
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.

Axiom
annotated source: mitotic cell cycle
annotated property: definition
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Cell Cycle, Mitotic
type: Axiom
annotated source: mitotic cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-69278

cell morphogenesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The developmental process in which the size or shape of a cell is generated and organized.
has_alternative_id: GO:0007148
has_alternative_id: GO:0045790
has_alternative_id: GO:0045791
has_exact_synonym: cellular morphogenesis
has_obo_namespace: biological_process
id: GO:0000902
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: cell morphogenesis
annotated property: definition
annotated target: The developmental process in which the size or shape of a cell is generated and organized.
database_cross_reference: GOC:clt
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb

opioid peptide activity
type: Class
subclass of: receptor ligand activity
definition: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.
has_obo_namespace: molecular_function
id: GO:0001515
in_subset: goslim chembl

Axiom
annotated source: opioid peptide activity
annotated property: definition
annotated target: Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.
database_cross_reference: ISBN:0198506732

N-acetylglucosamine 6-O-sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
database_cross_reference: Reactome:R-HSA-2046222
database_cross_reference: Reactome:R-HSA-3656269
database_cross_reference: Reactome:R-HSA-6786012
has_exact_synonym: N-acetylglucosamine 6-O-sulphotransferase activity
has_obo_namespace: molecular_function
id: GO:0001517
in_subset: goslim chembl

Axiom
annotated source: N-acetylglucosamine 6-O-sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.
database_cross_reference: GOC:ai
database_cross_reference: GOC:hjd

CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain
type: Axiom
annotated source: N-acetylglucosamine 6-O-sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2046222

Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG
type: Axiom
annotated source: N-acetylglucosamine 6-O-sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3656269

CHST4 transfers SO4(2-) from PAPS to Core 2 mucins
type: Axiom
annotated source: N-acetylglucosamine 6-O-sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786012

amyloid-beta binding
type: Class
subclass of: peptide binding
definition: Binding to an amyloid-beta peptide/protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/20109
has_exact_synonym: beta-amyloid binding
has_obo_namespace: molecular_function
id: GO:0001540
in_subset: goslim chembl

Axiom
annotated source: amyloid-beta binding
annotated property: definition
annotated target: Binding to an amyloid-beta peptide/protein.
database_cross_reference: GOC:hjd

virus receptor activity
type: Class
subclass of: protein binding
subclass of: Restriction
  on property: part of
  some values from: biological process involved in symbiotic interaction
definition: Combining with a virus component and mediating entry of the virus into the cell.
database_cross_reference: Reactome:R-HSA-9922480
has_exact_synonym: viral receptor activity
has_obo_namespace: molecular_function
id: GO:0001618
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: virus receptor activity
annotated property: definition
annotated target: Combining with a virus component and mediating entry of the virus into the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:dph
database_cross_reference: PMID:7621403
database_cross_reference: UniProtKB-KW:KW-1183

Dengue virion gets internalized
type: Axiom
annotated source: virus receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9922480

fibronectin binding
type: Class
subclass of: protein binding
definition: Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
has_obo_namespace: molecular_function
id: GO:0001968
in_subset: goslim chembl

Axiom
annotated source: fibronectin binding
annotated property: definition
annotated target: Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
database_cross_reference: GOC:hjd

immune system process
type: Class
subclass of: biological_process
definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
database_cross_reference: Wikipedia:Immune_system
has_obo_namespace: biological_process
id: GO:0002376
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).

Axiom
annotated source: immune system process
annotated property: definition
annotated target: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000022

circulatory system process
type: Class
subclass of: biological_process
definition: An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
database_cross_reference: Wikipedia:Circulatory_system
has_obo_namespace: biological_process
id: GO:0003013
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: circulatory system process
annotated property: definition
annotated target: An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
database_cross_reference: GOC:mtg_cardio

molecular_function
type: Class
definition: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
has_alternative_id: GO:0005554
has_exact_synonym: molecular function
has_obo_namespace: molecular_function
id: GO:0003674
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.

Axiom
annotated source: molecular_function
annotated property: definition
annotated target: A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
database_cross_reference: GOC:pdt

nucleic acid binding
type: Class
subclass of: molecular_function
definition: Binding to a nucleic acid.
has_alternative_id: GO:0000496
has_narrow_synonym: base pairing
has_obo_namespace: molecular_function
id: GO:0003676
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant

Axiom
annotated source: nucleic acid binding
annotated property: definition
annotated target: Binding to a nucleic acid.
database_cross_reference: GOC:jl

DNA binding
type: Class
subclass of: nucleic acid binding
definition: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
has_alternative_id: GO:0043566
has_narrow_synonym: plasmid binding
has_obo_namespace: molecular_function
has_related_synonym: microtubule/chromatin interaction
has_related_synonym: structure specific DNA binding
has_related_synonym: structure-specific DNA binding
id: GO:0003677
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: DNA binding
annotated property: definition
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

chromatin binding
type: Class
subclass of: molecular_function
definition: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
has_narrow_synonym: lamin/chromatin binding
has_narrow_synonym: microtubule/chromatin interaction
has_narrow_synonym: nuclear membrane vesicle binding to chromatin
has_obo_namespace: molecular_function
id: GO:0003682
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: chromatin binding
annotated property: definition
annotated target: Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:20404130

DNA-binding transcription factor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: has part
  some values from: DNA binding
definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
term tracker item: https://github.com/geneontology/go-ontology/issues/15704
term tracker item: https://github.com/geneontology/go-ontology/issues/16534
term tracker item: https://github.com/geneontology/go-ontology/issues/20253
created by: krc
creation date: 2010-10-21T04:37:54Z
has_alternative_id: GO:0000130
has_alternative_id: GO:0001071
has_alternative_id: GO:0001130
has_alternative_id: GO:0001131
has_alternative_id: GO:0001151
has_alternative_id: GO:0001199
has_alternative_id: GO:0001204
has_broad_synonym: nucleic acid binding transcription factor activity
has_broad_synonym: transcription factor activity
database_cross_reference: Reactome:R-HSA-163666
has_exact_synonym: DNA binding transcription factor activity
has_exact_synonym: gene-specific transcription factor activity
has_exact_synonym: sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
has_narrow_synonym: bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
has_narrow_synonym: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: metal ion regulated sequence-specific DNA binding transcription factor activity
has_narrow_synonym: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
has_narrow_synonym: transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
has_narrow_synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding
has_obo_namespace: molecular_function
id: GO:0003700
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast
comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.

Axiom
annotated source: DNA-binding transcription factor activity
annotated property: definition
annotated target: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
database_cross_reference: GOC:txnOH-2018

Formation of ChREBP:MLX heterodimer
type: Axiom
annotated source: DNA-binding transcription factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163666

RNA binding
type: Class
subclass of: nucleic acid binding
definition: Binding to an RNA molecule or a portion thereof.
has_alternative_id: GO:0000498
has_alternative_id: GO:0044822
database_cross_reference: Reactome:R-HSA-203922
has_narrow_synonym: base pairing with RNA
has_obo_namespace: molecular_function
has_related_synonym: poly(A) RNA binding
has_related_synonym: poly(A)-RNA binding
has_related_synonym: poly-A RNA binding
id: GO:0003723
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: RNA binding
annotated property: definition
annotated target: Binding to an RNA molecule or a portion thereof.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Axiom
annotated source: RNA binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203922

mRNA binding
type: Class
subclass of: RNA binding
definition: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
has_alternative_id: GO:0000499
has_narrow_synonym: base pairing with mRNA
has_obo_namespace: molecular_function
id: GO:0003729
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: mRNA binding
annotated property: definition
annotated target: Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
database_cross_reference: GOC:kmv
database_cross_reference: GOC:pr
database_cross_reference: SO:0000234

structural constituent of ribosome
type: Class
equivalent class: Class
  intersection of: structural molecule activity
  intersection of: Restriction
    on property: occurs in
    some values from: ribosome
subclass of: structural molecule activity
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
subclass of: Restriction
  on property: occurs in
  some values from: ribosome
definition: The action of a molecule that contributes to the structural integrity of the ribosome.
has_alternative_id: GO:0003736
has_alternative_id: GO:0003737
has_alternative_id: GO:0003738
has_alternative_id: GO:0003739
has_alternative_id: GO:0003740
has_alternative_id: GO:0003741
has_alternative_id: GO:0003742
has_broad_synonym: ribosomal protein
has_obo_namespace: molecular_function
has_related_synonym: ribosomal RNA
id: GO:0003735
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.

Axiom
annotated source: structural constituent of ribosome
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of the ribosome.
database_cross_reference: GOC:mah

antigen binding
type: Class
subclass of: molecular_function
definition: Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/25644
has_narrow_synonym: B cell receptor activity
has_narrow_synonym: MHC activity
has_narrow_synonym: major histocompatibility complex activity
has_narrow_synonym: major histocompatibility complex antigen display activity
has_narrow_synonym: opsonin activity
has_obo_namespace: molecular_function
has_related_synonym: antibody activity
id: GO:0003823
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: antigen binding
annotated property: definition
annotated target: Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
database_cross_reference: ISBN:0721662544

catalytic activity
type: Class
subclass of: molecular_function
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
id: GO:0003824
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon

Axiom
annotated source: catalytic activity
annotated property: definition
annotated target: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198506732

Axiom
annotated source: catalytic activity
annotated property: has_exact_synonym
annotated target: enzyme activity
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

1-alkyl-2-acetylglycerophosphocholine esterase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.1.47
database_cross_reference: MetaCyc:3.1.1.47-RXN
database_cross_reference: RHEA:17777
database_cross_reference: Reactome:R-HSA-8869206
has_exact_synonym: 2-acetyl-1-alkylglycerophosphocholine esterase activity
has_obo_namespace: molecular_function
has_related_synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
has_related_synonym: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
has_related_synonym: LDL-PLA(2) activity
has_related_synonym: LDL-PLA2
has_related_synonym: LDL-associated phospholipase A(2) activity
has_related_synonym: LDL-associated phospholipase A2
has_related_synonym: PAF 2-acylhydrolase activity
has_related_synonym: PAF acetylhydrolase activity
has_related_synonym: alkylacetyl-GPC:acetylhydrolase activity
has_related_synonym: platelet-activating factor acetylhydrolase activity
id: GO:0003847
in_subset: goslim chembl

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: definition
annotated target: Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+.
database_cross_reference: RHEA:17777

PAFAH2 hydrolyses PAF to lyso-PAF and acetate
type: Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8869206

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: LDL-PLA(2) activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: LDL-PLA2
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: LDL-associated phospholipase A(2) activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: LDL-associated phospholipase A2
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: PAF 2-acylhydrolase activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: PAF acetylhydrolase activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: alkylacetyl-GPC:acetylhydrolase activity
database_cross_reference: EC:3.1.1.47

Axiom
annotated source: 1-alkyl-2-acetylglycerophosphocholine esterase activity
annotated property: has_related_synonym
annotated target: platelet-activating factor acetylhydrolase activity
database_cross_reference: EC:3.1.1.47

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.6.3
database_cross_reference: KEGG_REACTION:R03503
database_cross_reference: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
database_cross_reference: RHEA:11412
has_exact_synonym: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity
has_obo_namespace: molecular_function
has_related_synonym: 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
has_related_synonym: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
has_related_synonym: 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
has_related_synonym: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
has_related_synonym: 7,8-dihydroxymethylpterin-pyrophosphokinase activity
has_related_synonym: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
has_related_synonym: H2-pteridine-CH2OH pyrophosphokinase activity
has_related_synonym: HPPK
has_related_synonym: hydroxymethyldihydropteridine pyrophosphokinase activity
id: GO:0003848
in_subset: goslim chembl

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: definition
annotated target: Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+.
database_cross_reference: EC:2.7.6.3
database_cross_reference: RHEA:11412

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: 6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: 7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: 7,8-dihydroxymethylpterin-pyrophosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: H2-pteridine-CH2OH pyrophosphokinase activity
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: HPPK
database_cross_reference: EC:2.7.6.3

Axiom
annotated source: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
annotated property: has_related_synonym
annotated target: hydroxymethyldihydropteridine pyrophosphokinase activity
database_cross_reference: EC:2.7.6.3

GTPase activity
type: Class
subclass of: ribonucleoside triphosphate phosphatase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
term tracker item: https://github.com/geneontology/go-ontology/issues/26014
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
created by: dph
creation date: 2015-11-11T12:47:56Z
has_alternative_id: GO:0061745
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
database_cross_reference: MetaCyc:RXN0-5462
database_cross_reference: RHEA:19669
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9018814
database_cross_reference: Reactome:R-HSA-9018826
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
database_cross_reference: Reactome:R-HSA-9947842
database_cross_reference: Reactome:R-HSA-9954919
has_narrow_synonym: ARF small monomeric GTPase activity
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation

Axiom
annotated source: GTPase activity
annotated property: definition
annotated target: Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
database_cross_reference: PMID:26832457
database_cross_reference: PMID:27218782

RAB8A,10,13,14 hydrolyze GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1445143

RALA hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1458485

Hydrolysis of eEF1A:GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156923

G alpha (s) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-164381

Hydrolysis of Ran:GTP to Ran:GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-165055

G-protein alpha subunit is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167415

Adenylate cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170666

Adenylaye cyclase increases the GTPase activity of G alpha-olf
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170685

Adenylate cyclase increases the GTPase activity of Gi alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170686

Endocytosis (internalization) of clathrin-coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177501

Vesicle budding
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203973

Translocation of TGN-lysosome vesicle to lysosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130641

Internalization of MHC II:Ii clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2130725

GNAT1-GTP hydrolyses its bound GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2584246

RHEB in mTORC1:RHEB:GTP hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380979

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392133

G alpha (i) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392212

G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418574

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418582

trans-Golgi Network Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-421835

P2Y purinoceptor 1 activates MAP kinase p38 alpha
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428941

trans-Golgi Network Lysosomal Vesicle Scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-432707

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333615

39S subunit binds 28S subunit:mRNA:fMet-tRNA
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389839

TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5389842

Hydrolysis of GTP and dissociation of 28S and 39S subunits
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419273

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5419279

Formation of clathrin coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-555065

ASAP1 stimulates GTPase activity of ARF4
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623513

ARL3 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638006

RAS GAPs stimulate RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5658231

SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5665809

Rheb in the MTORC1 complex hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672017

Loss of SAR1B GTPase
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694527

ARFGAPs stimulate ARF GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807877

TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814833

RAB43 hydrolyses GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847534

CYTH proteins stimulate ARF1 GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847883

ARHGAP35 stimulates RHOA GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849082

TBC RabGAPs accelerate GTP hydrolysis by RAB35
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854173

TBC1D2A accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854255

TBC1D15 accelerates GTP hydrolysis by RAB7
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854329

TBC1D16 accelerates GTP hydrolysis by RAB4A
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854604

TBC1D25 accelerates GTP hydrolysis by RAB33B
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8854612

Dynamin-mediated GTP hydrolysis promotes vesicle scission
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868661

RASA1 stimulates RAS GTPase activity
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8981353

G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982020

G alpha (z) in G alpha (z):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982021

G alpha (q) in G (q):RGS complex is inactivated
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982025

RHOT1 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018814

RHOT2 hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018826

RRAGA,B hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640195

RRAGC,D hydrolyzes GTP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9645598

RAS intrinsic GTPase activity hydrolyzes GTP to GDP
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9649736

Disassembly of COPII coated vesicle
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-983422

GBP1 hydrolyzes GTP forming GBP1 oligomers
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9947842

ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released
type: Axiom
annotated source: GTPase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9954919

acetylcholinesterase activity
type: Class
subclass of: cholinesterase activity
definition: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.1.7
database_cross_reference: MetaCyc:ACETYLCHOLINESTERASE-RXN
database_cross_reference: RHEA:17561
database_cross_reference: Reactome:R-HSA-372519
has_obo_namespace: molecular_function
has_related_synonym: AcCholE
has_related_synonym: acetyl.beta-methylcholinesterase activity
has_related_synonym: acetylcholine acetylhydrolase activity
has_related_synonym: acetylcholine hydrolase activity
has_related_synonym: acetylthiocholinesterase activity
has_related_synonym: choline esterase I activity
has_related_synonym: true cholinesterase activity
id: GO:0003990
in_subset: goslim chembl

Axiom
annotated source: acetylcholinesterase activity
annotated property: definition
annotated target: Catalysis of the reaction: acetylcholine + H2O = choline + acetate.
database_cross_reference: EC:3.1.1.7

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Axiom
annotated source: acetylcholinesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-372519

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: AcCholE
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: acetyl.beta-methylcholinesterase activity
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: acetylcholine acetylhydrolase activity
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: acetylcholine hydrolase activity
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: acetylthiocholinesterase activity
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: choline esterase I activity
database_cross_reference: EC:3.1.1.7

Axiom
annotated source: acetylcholinesterase activity
annotated property: has_related_synonym
annotated target: true cholinesterase activity
database_cross_reference: EC:3.1.1.7

adenosylhomocysteinase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
term tracker item: https://github.com/geneontology/go-ontology/issues/24053
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: S-adenosylhomocysteine hydrolase activity
database_cross_reference: EC:3.13.2.1
database_cross_reference: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN
database_cross_reference: RHEA:21708
database_cross_reference: Reactome:R-HSA-174401
database_cross_reference: Reactome:R-HSA-5579084
has_obo_namespace: molecular_function
has_related_synonym: AdoHcyase activity
has_related_synonym: S-adenosyl-L-homocysteine hydrolase activity
has_related_synonym: S-adenosylhomocysteinase activity
has_related_synonym: S-adenosylhomocysteine synthase activity
has_related_synonym: SAHase activity
has_related_synonym: adenosylhomocysteine hydrolase activity
id: GO:0004013
in_subset: goslim chembl

Axiom
annotated source: adenosylhomocysteinase activity
annotated property: definition
annotated target: Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
database_cross_reference: RHEA:21708

AHCY:NAD+ tetramer hydrolyses AdoHcy
type: Axiom
annotated source: adenosylhomocysteinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-174401

Defective AHCY does not hydrolyse AdoHcy
type: Axiom
annotated source: adenosylhomocysteinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5579084

alcohol sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: estrogen sulfotransferase
has_broad_synonym: steroid alcohol sulfotransferase
database_cross_reference: EC:2.8.2.2
database_cross_reference: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:22552
database_cross_reference: Reactome:R-HSA-176494
database_cross_reference: Reactome:R-HSA-176609
has_exact_synonym: alcohol sulphotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
has_related_synonym: 3-hydroxysteroid sulfotransferase activity
has_related_synonym: 3beta-hydroxy steroid sulfotransferase activity
has_related_synonym: 3beta-hydroxysteroid sulfotransferase activity
has_related_synonym: 5alpha-androstenol sulfotransferase activity
has_related_synonym: HST
has_related_synonym: alcohol/hydroxysteroid sulfotransferase activity
has_related_synonym: dehydroepiandrosterone sulfotransferase activity
has_related_synonym: delta5-3beta-hydroxysteroid sulfokinase activity
has_related_synonym: estrogen sulfokinase activity
has_related_synonym: hydroxysteroid sulfotransferase activity
has_related_synonym: steroid sulfokinase activity
has_related_synonym: sterol sulfokinase activity
has_related_synonym: sterol sulfotransferase activity
id: GO:0004027
in_subset: goslim chembl

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_broad_synonym
annotated target: estrogen sulfotransferase
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_broad_synonym
annotated target: steroid alcohol sulfotransferase
database_cross_reference: EC:2.8.2.2

SULTs transfer (SO4)2- group to 27HCHOL
type: Axiom
annotated source: alcohol sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176494

cholesterol + PAPS => cholesterol sulfate + PAP
type: Axiom
annotated source: alcohol sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176609

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3-hydroxysteroid sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3beta-hydroxy steroid sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3beta-hydroxysteroid sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: 5alpha-androstenol sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: HST
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: alcohol/hydroxysteroid sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: dehydroepiandrosterone sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: delta5-3beta-hydroxysteroid sulfokinase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: estrogen sulfokinase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: hydroxysteroid sulfotransferase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: steroid sulfokinase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: sterol sulfokinase activity
database_cross_reference: EC:2.8.2.2

Axiom
annotated source: alcohol sulfotransferase activity
annotated property: has_related_synonym
annotated target: sterol sulfotransferase activity
database_cross_reference: EC:2.8.2.2

aryl sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: arylsulfotransferase
database_cross_reference: EC:2.8.2.1
database_cross_reference: MetaCyc:ARYL-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:12164
database_cross_reference: Reactome:R-HSA-158468
database_cross_reference: Reactome:R-HSA-158849
database_cross_reference: Reactome:R-HSA-158860
database_cross_reference: Reactome:R-HSA-159358
database_cross_reference: Reactome:R-HSA-176474
database_cross_reference: Reactome:R-HSA-176585
database_cross_reference: Reactome:R-HSA-176646
has_exact_synonym: aryl sulphotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 1-naphthol phenol sulfotransferase activity
has_related_synonym: 2-naphtholsulfotransferase activity
has_related_synonym: 3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
has_related_synonym: 4-nitrocatechol sulfokinase activity
has_related_synonym: PST
has_related_synonym: dopamine sulfotransferase activity
has_related_synonym: p-nitrophenol sulfotransferase activity
has_related_synonym: phenol sulfokinase activity
has_related_synonym: phenol sulfotransferase activity
has_related_synonym: ritodrine sulfotransferase activity
has_related_synonym: sulfokinase activity
id: GO:0004062
in_subset: goslim chembl

Axiom
annotated source: aryl sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_broad_synonym
annotated target: arylsulfotransferase
database_cross_reference: EC:2.8.2.1

SULT1A1 dimer sulfonates PARA to PARA-SO4
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158468

Phenol can form a sulfate conjugate
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158849

SULT1A1 dimer sulfonates NHABP
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158860

SULT1A3,4 dimers sulfate DA to DAOS
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159358

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176474

3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176585

p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
type: Axiom
annotated source: aryl sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176646

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: 1-naphthol phenol sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: 2-naphtholsulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: 4-nitrocatechol sulfokinase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: PST
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: dopamine sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: p-nitrophenol sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: phenol sulfokinase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: phenol sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: ritodrine sulfotransferase activity
database_cross_reference: EC:2.8.2.1

Axiom
annotated source: aryl sulfotransferase activity
annotated property: has_related_synonym
annotated target: sulfokinase activity
database_cross_reference: EC:2.8.2.1

cholinesterase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.1.8
database_cross_reference: MetaCyc:CHOLINESTERASE-RXN
database_cross_reference: RHEA:21964
has_obo_namespace: molecular_function
has_related_synonym: BtChoEase activity
has_related_synonym: acylcholine acylhydrolase activity
has_related_synonym: anticholineesterase activity
has_related_synonym: benzoylcholinesterase activity
has_related_synonym: butyrylcholine esterase activity
has_related_synonym: butyrylcholinesterase activity
has_related_synonym: choline esterase II (unspecific) activity
has_related_synonym: choline esterase activity
has_related_synonym: non-specific cholinesterase activity
has_related_synonym: propionylcholinesterase activity
has_related_synonym: pseudocholinesterase activity
id: GO:0004104
in_subset: goslim chembl

Axiom
annotated source: cholinesterase activity
annotated property: definition
annotated target: Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: BtChoEase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: acylcholine acylhydrolase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: anticholineesterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: benzoylcholinesterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: butyrylcholine esterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: butyrylcholinesterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: choline esterase II (unspecific) activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: choline esterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: non-specific cholinesterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: propionylcholinesterase activity
database_cross_reference: EC:3.1.1.8

Axiom
annotated source: cholinesterase activity
annotated property: has_related_synonym
annotated target: pseudocholinesterase activity
database_cross_reference: EC:3.1.1.8

dUTP diphosphatase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.6.1.23
database_cross_reference: KEGG_REACTION:R02100
database_cross_reference: MetaCyc:DUTP-PYROP-RXN
database_cross_reference: RHEA:10248
database_cross_reference: Reactome:R-HSA-73666
has_exact_synonym: dUTP pyrophosphatase activity
has_obo_namespace: molecular_function
has_related_synonym: dUTP nucleotidohydrolase activity
has_related_synonym: dUTPase activity
has_related_synonym: deoxyuridine-triphosphatase activity
has_related_synonym: desoxyuridine 5'-triphosphatase activity
has_related_synonym: desoxyuridine 5'-triphosphate nucleotidohydrolase activity
id: GO:0004170
in_subset: goslim chembl

Axiom
annotated source: dUTP diphosphatase activity
annotated property: definition
annotated target: Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate.
database_cross_reference: RHEA:10248

dUTP + H2O => dUMP + pyrophosphate
type: Axiom
annotated source: dUTP diphosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-73666

Axiom
annotated source: dUTP diphosphatase activity
annotated property: has_related_synonym
annotated target: dUTP nucleotidohydrolase activity
database_cross_reference: EC:3.6.1.23

Axiom
annotated source: dUTP diphosphatase activity
annotated property: has_related_synonym
annotated target: dUTPase activity
database_cross_reference: EC:3.6.1.23

Axiom
annotated source: dUTP diphosphatase activity
annotated property: has_related_synonym
annotated target: deoxyuridine-triphosphatase activity
database_cross_reference: EC:3.6.1.23

Axiom
annotated source: dUTP diphosphatase activity
annotated property: has_related_synonym
annotated target: desoxyuridine 5'-triphosphatase activity
database_cross_reference: EC:3.6.1.23

Axiom
annotated source: dUTP diphosphatase activity
annotated property: has_related_synonym
annotated target: desoxyuridine 5'-triphosphate nucleotidohydrolase activity
database_cross_reference: EC:3.6.1.23

serine-type endopeptidase activity
type: Class
subclass of: peptidase activity
definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
term tracker item: https://github.com/geneontology/go-ontology/issues/20581
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.4.21.-
database_cross_reference: EC:3.4.21.1
database_cross_reference: EC:3.4.21.10
database_cross_reference: EC:3.4.21.102
database_cross_reference: EC:3.4.21.20
database_cross_reference: EC:3.4.21.21
database_cross_reference: EC:3.4.21.22
database_cross_reference: EC:3.4.21.26
database_cross_reference: EC:3.4.21.27
database_cross_reference: EC:3.4.21.34
database_cross_reference: EC:3.4.21.35
database_cross_reference: EC:3.4.21.36
database_cross_reference: EC:3.4.21.38
database_cross_reference: EC:3.4.21.39
database_cross_reference: EC:3.4.21.4
database_cross_reference: EC:3.4.21.41
database_cross_reference: EC:3.4.21.42
database_cross_reference: EC:3.4.21.43
database_cross_reference: EC:3.4.21.45
database_cross_reference: EC:3.4.21.46
database_cross_reference: EC:3.4.21.47
database_cross_reference: EC:3.4.21.48
database_cross_reference: EC:3.4.21.5
database_cross_reference: EC:3.4.21.53
database_cross_reference: EC:3.4.21.54
database_cross_reference: EC:3.4.21.59
database_cross_reference: EC:3.4.21.6
database_cross_reference: EC:3.4.21.61
database_cross_reference: EC:3.4.21.62
database_cross_reference: EC:3.4.21.68
database_cross_reference: EC:3.4.21.69
database_cross_reference: EC:3.4.21.7
database_cross_reference: EC:3.4.21.71
database_cross_reference: EC:3.4.21.73
database_cross_reference: EC:3.4.21.75
database_cross_reference: EC:3.4.21.78
database_cross_reference: EC:3.4.21.79
database_cross_reference: EC:3.4.21.83
database_cross_reference: EC:3.4.21.88
database_cross_reference: EC:3.4.21.9
database_cross_reference: EC:3.4.21.92
database_cross_reference: EC:3.4.21.93
database_cross_reference: EC:3.4.21.94
database_cross_reference: Reactome:R-HSA-114697
database_cross_reference: Reactome:R-HSA-1181152
database_cross_reference: Reactome:R-HSA-139893
database_cross_reference: Reactome:R-HSA-140599
database_cross_reference: Reactome:R-HSA-140664
database_cross_reference: Reactome:R-HSA-140696
database_cross_reference: Reactome:R-HSA-140700
database_cross_reference: Reactome:R-HSA-140736
database_cross_reference: Reactome:R-HSA-140769
database_cross_reference: Reactome:R-HSA-140777
database_cross_reference: Reactome:R-HSA-140823
database_cross_reference: Reactome:R-HSA-140840
database_cross_reference: Reactome:R-HSA-140870
database_cross_reference: Reactome:R-HSA-141026
database_cross_reference: Reactome:R-HSA-141040
database_cross_reference: Reactome:R-HSA-1454843
database_cross_reference: Reactome:R-HSA-1474197
database_cross_reference: Reactome:R-HSA-1566962
database_cross_reference: Reactome:R-HSA-1566979
database_cross_reference: Reactome:R-HSA-1566981
database_cross_reference: Reactome:R-HSA-158137
database_cross_reference: Reactome:R-HSA-158164
database_cross_reference: Reactome:R-HSA-158300
database_cross_reference: Reactome:R-HSA-158311
database_cross_reference: Reactome:R-HSA-158313
database_cross_reference: Reactome:R-HSA-158333
database_cross_reference: Reactome:R-HSA-158419
database_cross_reference: Reactome:R-HSA-158744
database_cross_reference: Reactome:R-HSA-158747
database_cross_reference: Reactome:R-HSA-158750
database_cross_reference: Reactome:R-HSA-158766
database_cross_reference: Reactome:R-HSA-158925

Axiom
annotated source: serine-type endopeptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
database_cross_reference: GOC:mah
database_cross_reference: https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE

Activated thrombin (factor IIa) cleaves PAR3,4, activating them
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114697

Cleavage of NODAL proprotein
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1181152

Granzyme-B activates BID by cleavage
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-139893

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140599

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140664

factor V -> factor Va + factor V activation peptide (thrombin catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140696

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140700

factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140736

factor VII -> factor VIIa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140769

factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140777

factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140823

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140840

thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-140870

Activated protein C cleaves factor Va to factor Vi intermediate form
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-141026

Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-141040

E-cadherin degradation by MMP3, MMP7 and plasmin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1454843

Collagen type II degradation by MMP1,3,8,13,PRSS2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1474197

Elastin degradation by elastin-degrading extracellular proteinases
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1566962

Laminin-332 degradation by laminin-322 degrading extracellular proteinases
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1566979

Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1566981

factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158137

factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158164

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158300

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158311

factor XII -> factor XIIa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158313

factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158333

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158419

crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158744

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158747

crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158750

fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158766

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158925

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158942

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-158982

NID1 degradation by MMP1, 9, 12, ELANE
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592270

Autocatalytic activation of proMMP2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592278

Full activation of MMP1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592297

HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592314

Initial activation of proMMP1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592316

Activation of proMMP7 by MMP3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592362

Initial activation of proMMP3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592371

Activation of proMMP8
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592398

Initial activation of proMMP9 by MMPs
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592436

Furin cleaves pro-prothrombin to prothrombin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159728

Furin cleaves pro-factor X to factor X
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159733

Furin cleaves pro-protein C to protein C
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159771

Furin cleaves pro-protein S to protein S
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159773

Furin cleaves pro-factor IX to factor IX
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159796

Furin cleaves pro-factor VII to factor VII
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159868

Activation of proMMP10
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602458

Activation of MT-MMPs by FURIN
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602466

Autocatalytic activation of MMP1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602473

Activation of proMMP11 by FURIN
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602484

Initial activation of proMMP13 by plasmin and trypsin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602488

Initial activation of proMMP2 by MMP1, 7
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604359

Initial activation of proMMP2 by MMP14
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604360

Autocatalytic activation of bound proMMP2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604368

Activation of MMP9 intermediate form by MMPs
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604690

Initial activation of proMMP7 by trypsin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604712

Activation of proMMP9 by proteases
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604722

Autocatalytic activation of MMP3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604731

Autocatalytic activation of proMMP13
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604732

Initial activation of proMMP13 by MMP14 (MT1-MMP)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604741

Initial activation of proMMP13 by MMP3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604752

Autocatalytic activation of MMP7
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1604763

Furin cleaves pro-protein Z to protein Z
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163798

Furin cleaves pro-GAS6 to GAS6
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163843

S1P hydrolyzes SREBP1A,1C,2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1655842

Conversion of C4 into C4a and C4b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-166753

Conversion of C2 into C2a and C2b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-166792

Cleavage of C3 by C3 convertases
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-166817

Latent TGF-beta-1 is cleaved by FURIN
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170844

Cleavage of the viral Env gp160 precursor polyprotein
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-171288

Activation of C1r
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-173626

Activation of C1s
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-173631

Activation of C5
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-173680

Factor D cleaves C3(H2O)-bound Factor B
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-173745

Formation of alternative pathway C5 convertase
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-174551

Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1799329

Factor D cleaves C3b-bound Factor B
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-183122

C3(H2O):Factor Bb cleaves C3 to C3b and C3a
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-183130

PDGF-AA clevage by Furin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-186785

Part of pro-beta-NGF is processed to mature beta-NGF
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-187020

NOTCH precursor cleaved to form mature NOTCH
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1912369

Fringe-modified Pre-NOTCH is cleaved by FURIN
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1912372

Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2022411

Fibrillin C-terminal processing
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2129357

Collagen type XVIII endostatin release
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2168923

Collagen type XVII ectodomain shedding
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2168960

Collagen type XXIII ectodomain shedding
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2172405

Cleavage of collagen VII NC2 region by BMP1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2214330

Endostatin degradation by cathepsins
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2471621

Collagen type XXV ectomain shedding
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2471842

Collagen type VIII degradation by ELANE
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2482180

Fibrillin-1 degradation by MMP3, CTSK, CTSL2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2514772

Fibrillin-1 degradation by ELANE
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2514823

HSPG2 (perlecan) degradation by MMP13, CTSS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2534160

E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2534206

E-cadherin degradation by caspase-3 and calpain-1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2534260

Corticotropin cleavage from POMC
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-265301

DENV protease NS2B3 cleaves STING
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3244626

Factor I cleaves iC3b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3266557

Fibronectin degradation by CTSG
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3785684

Fibronectin degradation by ADAM8
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3788061

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381135

Thrombin proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381446

Plasmin proteolyzes IGF:IGFBP-3:ALS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381461

Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381466

HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3814820

Cathepsin G proteolyzes IGF:IGFBP3:ALS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381500

PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381798

Extracellular processing of novel PDGFs
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382061

MMP2,9 cleave EPHB
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928657

Signal peptidase hydrolyzes preproGLP-1 to proGLP-1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400459

PCSK1 hydrolyzes proGIP to GIP
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400492

Signal peptidase hydrolyzes preproGIP to proGIP
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400496

PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-422021

Cleavage of the signal peptide of Preproghrelin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-422051

Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5210912

Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5210935

CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5578783

Activated protein C cleaves Factor Va intermediate form for Factor Va
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5591040

Activated protein C cleaves factor VIIIa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5607002

APEH hydrolyses NAc-Ser-protein
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5691512

HPN heterodimer cleaves pro-MST1 to form MST1 dimer
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800198

HPN heterodimer cleaves pro-HGF to form HGF dimer
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800200

HGFAC cleaves pro-HGF to form HGF dimer
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800299

PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6801687

Furin cleaves pro-BGLAP to BGLAP
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807224

ST14 hydrolyzes and activates KLK5
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849826

KLK5 cleaves and activates CELA2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8849857

KLK5 cleaves and activates KLK8
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8850831

Thrombin, ELANE cleave C5
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8852716

HTRA1 hydrolyzes ACAN (Aggrecan)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8855825

PDGF-BB clevage by Furin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8865275

PDGF-AB clevage by Furin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8865276

MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874145

MBTPS1 (S1P) cleaves CREB3L4
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874186

MBTPS1 (S1P) cleaves CREB3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874204

MBTPS1 (S1P) cleaves CREB3L2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874205

MBTPS1 (S1P) cleaves CREB3L3
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874206

MBTPS1 (S1P) cleaves CREB3L1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8874212

PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023178

PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023196

DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023626

DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023627

DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023632

DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023633

TYSND1 cleaves PHYH
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033490

TYSND1 cleaves AGPS
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033506

TYSND1 cleaves ACOX1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033515

TYSND1 cleaves TYSND1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033520

TYSND1 cleaves SCP2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033524

TYSND1 cleaves ACAA1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033529

TYSND1 cleaves HSD17B4
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033530

Cleavage of factor XII variant by activated thrombin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9653249

Cleavage of FXII variant by KLKB1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9655046

FURIN cleaves ADAM17
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9662786

F8 variant is not cleaved by thrombin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666383

Hyperactivation of factor X by FVIIIa:FIXa R384L
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9668253

FVIIIa variant:FIXa does not convert FX to the active FXa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9668365

FIXa variant:FVIIIa does not convert FX to the active FXa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9670874

FIX(29-461) variant is not activated (factor XIa catalyst)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9673223

Cleavage of S protein into S1:S2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9686710

TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9686731

Cleavage of S protein into S1:S2
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9694287

TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9694661

Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9698988

FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9699007

Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9708859

ELANE cleaves GSDMD
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9710106

GZMB cleaves GSDME
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9710263

Factor I inactivates plasma Factor H-bound C3b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-976743

FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9769949

S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9770187

Factor I inactivates Factor H-boundC3b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-977371

Factor I inactivates MCP/CR1-bound C4b/C3b
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-977615

CDH1 is proteolytically cleaved in Golgi
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9816275

Nascent F signal peptide is cleaved at ER membrane
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9829030

F0 is cleaved, releasing F1, F2, F(110-136)
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9829200

Nascent sG localizes to ER lumen, gets glycosylated
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9830805

Nascent G signal peptide is cleaved at ER membrane
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9830882

TGFBR3_mem cleavage by MMPs
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9839367

ELANE cleaves NOTCH2NLA
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9911236

LepB cleaves prepro-STa
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9911383

LepB cleaves pre-EltA
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9912368

LepB cleaves pre-EltB
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9912371

Autoproteolysis of DAG1 to alpha and beta chains
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9913329

Dengue polyprotein cis-auto-cleaves
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918772

Unknown peptidase cleaves NS1-NS2A
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918780

NS2B3 cleaves C-prM-E-NS1-NS2A
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918787

Signalase cleaves prM-E-NS1-NS2A
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918795

NS2B3 cleaves NS4AB
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918813

NS2B3 cleaves polyprotein
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918817

NS345:NS2B cleaves NS345
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918823

Signalase cleaves prepro-NS4B
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918871

NS2B3 cleaves prepro-C at the C-prM junction
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9918876

Furin cleaves prM:E
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9919050

NS2B3 cleaves FAM134B
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9921595

NS3 cleaves GrpEL1
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9921689

EspC(54-1018) cleaves hemoglobin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9926936

Hbp cis-autocleaves
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9926963

Hbp(53-1100) cleaves hemoglobin
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9927009

Removal of CDH1 signal peptide
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9932162

ACOT2 cleaves NS345
type: Axiom
annotated source: serine-type endopeptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9947496

Axiom
annotated source: serine-type endopeptidase activity
annotated property: has_related_synonym
annotated target: serine elastase activity
database_cross_reference: GOC:krc

epoxide hydrolase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: an epoxide + H2O = an ethanediol.
term tracker item: https://github.com/geneontology/go-ontology/issues/27074
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: arene-oxide hydratase activity
has_broad_synonym: aryl epoxide hydrase activity
has_broad_synonym: epoxide hydrase activity
has_broad_synonym: epoxide hydratase activity
database_cross_reference: EC:3.3.2.10
database_cross_reference: MetaCyc:3.3.2.10-RXN
database_cross_reference: RHEA:19037
database_cross_reference: Reactome:R-HSA-2161961
database_cross_reference: Reactome:R-HSA-9018862
database_cross_reference: Reactome:R-HSA-9018877
database_cross_reference: Reactome:R-HSA-9020252
database_cross_reference: Reactome:R-HSA-9020253
database_cross_reference: Reactome:R-HSA-9020257
database_cross_reference: Reactome:R-HSA-9020258
database_cross_reference: Reactome:R-HSA-9020270
database_cross_reference: Reactome:R-HSA-9024890
database_cross_reference: Reactome:R-HSA-9024973
database_cross_reference: Reactome:R-HSA-9024993
database_cross_reference: Reactome:R-HSA-9025998
database_cross_reference: Reactome:R-HSA-9026000
database_cross_reference: Reactome:R-HSA-9026008
database_cross_reference: Reactome:R-HSA-9915968
database_cross_reference: Reactome:R-HSA-9915986
database_cross_reference: Reactome:R-HSA-9915994
has_narrow_synonym: soluble epoxide hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: cytosolic epoxide hydrolase activity
has_related_synonym: sEH
has_related_synonym: trans-stilbene oxide hydrolase activity
id: GO:0004301
in_subset: goslim chembl

Axiom
annotated source: epoxide hydrolase activity
annotated property: definition
annotated target: Catalysis of the reaction: an epoxide + H2O = an ethanediol.
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_broad_synonym
annotated target: arene-oxide hydratase activity
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_broad_synonym
annotated target: aryl epoxide hydrase activity
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_broad_synonym
annotated target: epoxide hydrase activity
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_broad_synonym
annotated target: epoxide hydratase activity
database_cross_reference: EC:3.3.2.10

5,6-EET is hydrolysed to 5,6-DHET by EPHX2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161961

LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018862

LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018877

LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020252

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020253

LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020257

LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020258

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020270

LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024890

Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024973

EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024993

Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025998

Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026000

Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026008

8,9-EET is hydrolysed to 8.9-DHET by EPHX2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9915968

11,12-EET is hydrolysed to 11,12-DHET by EPHX2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9915986

14,15-EET is hydrolysed to 14,15-DHET by EPHX2
type: Axiom
annotated source: epoxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9915994

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: soluble epoxide hydrolase activity
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_related_synonym
annotated target: cytosolic epoxide hydrolase activity
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_related_synonym
annotated target: sEH
database_cross_reference: EC:3.3.2.10

Axiom
annotated source: epoxide hydrolase activity
annotated property: has_related_synonym
annotated target: trans-stilbene oxide hydrolase activity
database_cross_reference: EC:3.3.2.10

helicase activity
type: Class
subclass of: isomerase activity
subclass of: ATP-dependent activity
definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
term tracker item: https://github.com/geneontology/go-ontology/issues/21393
term tracker item: https://github.com/geneontology/go-ontology/issues/29690
has_alternative_id: GO:0008026
database_cross_reference: Reactome:R-HSA-169461
database_cross_reference: Reactome:R-HSA-169468
database_cross_reference: Reactome:R-HSA-5686410
database_cross_reference: Reactome:R-HSA-5690996
database_cross_reference: Reactome:R-HSA-9922957
database_cross_reference: Reactome:R-HSA-9923073
has_exact_synonym: ATP-dependent helicase activity
has_obo_namespace: molecular_function
id: GO:0004386
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast
comment: Note that most helicases catalyze processive duplex unwinding.

Axiom
annotated source: helicase activity
annotated property: definition
annotated target: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
database_cross_reference: GOC:jl

MCM8 mediated fork unwinding
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169461

MCM2-7 mediated fork unwinding
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169468

BLM mediates dissolution of double Holliday junction
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686410

ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690996

NS3 melts (+)-RNA secondary structures
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9922957

NS3 unwinds dsRNA secondary structures
type: Axiom
annotated source: helicase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9923073

juvenile-hormone esterase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.1.59
database_cross_reference: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN
database_cross_reference: RHEA:16393
has_obo_namespace: molecular_function
has_related_synonym: JH esterase activity
has_related_synonym: JH-esterase activity
has_related_synonym: juvenile hormone analog esterase activity
has_related_synonym: juvenile hormone carboxyesterase activity
has_related_synonym: methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity
id: GO:0004453
in_subset: goslim chembl

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: definition
annotated target: Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.
database_cross_reference: PMID:11267890
database_cross_reference: RHEA:16393

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: has_related_synonym
annotated target: JH esterase activity
database_cross_reference: EC:3.1.1.59

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: has_related_synonym
annotated target: JH-esterase activity
database_cross_reference: EC:3.1.1.59

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: has_related_synonym
annotated target: juvenile hormone analog esterase activity
database_cross_reference: EC:3.1.1.59

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: has_related_synonym
annotated target: juvenile hormone carboxyesterase activity
database_cross_reference: EC:3.1.1.59

Axiom
annotated source: juvenile-hormone esterase activity
annotated property: has_related_synonym
annotated target: methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity
database_cross_reference: EC:3.1.1.59

nuclease activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the cleavage of ester linkages within nucleic acids.
term tracker item: https://github.com/geneontology/go-ontology/issues/24408
has_obo_namespace: molecular_function
id: GO:0004518
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim plant
in_subset: goslim yeast
comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases.

Axiom
annotated source: nuclease activity
annotated property: definition
annotated target: Catalysis of the cleavage of ester linkages within nucleic acids.
database_cross_reference: ISBN:0198547684

glycerophospholipase activity
type: Class
subclass of: lipase activity
definition: Catalysis of the hydrolysis of a glycerophospholipid.
term tracker item: https://github.com/geneontology/go-ontology/issues/21843
term tracker item: https://github.com/geneontology/go-ontology/issues/30258
term tracker item: https://github.com/geneontology/go-ontology/issues/31030
database_cross_reference: Reactome:R-HSA-6786650
database_cross_reference: Reactome:R-HSA-6792445
has_exact_synonym: glycerophospholipid hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: phospholipase activity
id: GO:0004620
in_subset: goslim chembl

Axiom
annotated source: glycerophospholipase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a glycerophospholipid.
database_cross_reference: PMID:30109646

DDHD1,2 hydrolyse PA
type: Axiom
annotated source: glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786650

LIPH, I hydrolyse PA to 2-acyl LPA
type: Axiom
annotated source: glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6792445

phosphatidylcholine lysophospholipase A1 activity
type: Class
subclass of: glycerophospholipase activity
definition: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.
term tracker item: https://github.com/geneontology/go-ontology/issues/27557
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
term tracker item: https://github.com/geneontology/go-ontology/issues/30258
has_alternative_id: GO:0045126
has_broad_synonym: lysophospholipase activity
database_cross_reference: EC:3.1.1.5
database_cross_reference: MetaCyc:LYSOPHOSPHOLIPASE-RXN
database_cross_reference: RHEA:15177
database_cross_reference: Reactome:R-HSA-1482545
database_cross_reference: Reactome:R-HSA-1482571
database_cross_reference: Reactome:R-HSA-1482612
database_cross_reference: Reactome:R-HSA-1482629
database_cross_reference: Reactome:R-HSA-1482685
database_cross_reference: Reactome:R-HSA-1482696
database_cross_reference: Reactome:R-HSA-6814254
database_cross_reference: Reactome:R-HSA-6814766
database_cross_reference: Reactome:R-HSA-6814778
database_cross_reference: Reactome:R-HSA-8847912
has_exact_synonym: phosphatidylcholine lysophospholipase A1-type activity
has_obo_namespace: molecular_function
has_related_synonym: 2-lysophosphatidylcholine acylhydrolase activity
has_related_synonym: lecithinase B activity
has_related_synonym: lecitholipase activity
has_related_synonym: lysolecithinase activity
has_related_synonym: lysophopholipase L2
has_related_synonym: lysophosphatidase activity
has_related_synonym: lysophosphatidylcholine hydrolase activity
has_related_synonym: lysophospholipase A1
has_related_synonym: phosphatidase B
has_related_synonym: phospholipase B activity
id: GO:0004622
in_subset: goslim chembl

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: definition
annotated target: Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.
database_cross_reference: RHEA:15177

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_broad_synonym
annotated target: lysophospholipase activity
database_cross_reference: EC:3.1.1.5

2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482545

1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482571

2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482612

2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482629

1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482685

1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482696

PNPLA6 hydrolyzes LysoPtdCho
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814254

GDPD1 hydrolyzes LysoPtdCho
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814766

GDPD3 hydrolyzes LysoPtdCho
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6814778

PNPLA7 hydrolyzes LysoPtdCho
type: Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8847912

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: 2-lysophosphatidylcholine acylhydrolase activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lecithinase B activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lecitholipase activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lysolecithinase activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lysophopholipase L2
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lysophosphatidase activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lysophosphatidylcholine hydrolase activity
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: lysophospholipase A1
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: phosphatidase B
database_cross_reference: EC:3.1.1.5

Axiom
annotated source: phosphatidylcholine lysophospholipase A1 activity
annotated property: has_related_synonym
annotated target: phospholipase B activity
database_cross_reference: EC:3.1.1.5

A2-type glycerophospholipase activity
type: Class
subclass of: glycerophospholipase activity
definition: A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
term tracker item: https://github.com/geneontology/go-ontology/issues/21259
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
term tracker item: https://github.com/geneontology/go-ontology/issues/30258
term tracker item: https://github.com/geneontology/go-ontology/issues/31049
term tracker item: https://github.com/geneontology/go-ontology/issues/31198
has_alternative_id: GO:0102567
has_alternative_id: GO:0102568
database_cross_reference: EC:3.1.1.4
database_cross_reference: MetaCyc:PHOSPHOLIPASE-A2-RXN
database_cross_reference: MetaCyc:RXN-15065
database_cross_reference: MetaCyc:RXN-15067
database_cross_reference: RHEA:15801
database_cross_reference: Reactome:R-HSA-1482604
database_cross_reference: Reactome:R-HSA-1482656
database_cross_reference: Reactome:R-HSA-1482679
database_cross_reference: Reactome:R-HSA-1482745
database_cross_reference: Reactome:R-HSA-1482759
database_cross_reference: Reactome:R-HSA-1482771
database_cross_reference: Reactome:R-HSA-1482776
database_cross_reference: Reactome:R-HSA-1482778
database_cross_reference: Reactome:R-HSA-1482816
database_cross_reference: Reactome:R-HSA-1482825
database_cross_reference: Reactome:R-HSA-1482856
database_cross_reference: Reactome:R-HSA-1482868
database_cross_reference: Reactome:R-HSA-1482884
database_cross_reference: Reactome:R-HSA-1482887
database_cross_reference: Reactome:R-HSA-1482897
database_cross_reference: Reactome:R-HSA-1482900
database_cross_reference: Reactome:R-HSA-1482907
database_cross_reference: Reactome:R-HSA-1602368
database_cross_reference: Reactome:R-HSA-1602374
database_cross_reference: Reactome:R-HSA-1602377
database_cross_reference: Reactome:R-HSA-1602398
database_cross_reference: Reactome:R-HSA-1602399
database_cross_reference: Reactome:R-HSA-1602417
database_cross_reference: Reactome:R-HSA-1602446
database_cross_reference: Reactome:R-HSA-8848484
has_exact_synonym: phospholipase A2 activity
has_narrow_synonym: cytosolic phospholipase A2 activity
has_narrow_synonym: phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
has_narrow_synonym: phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
has_narrow_synonym: secreted phospholipase A2 activity
has_obo_namespace: molecular_function
has_related_synonym: lecithinase A activity
has_related_synonym: phosphatidase activity
has_related_synonym: phosphatidolipase activity
has_related_synonym: phosphatidylcholine 2-acylhydrolase activity
id: GO:0004623
in_subset: goslim chembl
narrow match: RXN-15065
narrow match: http://rdf.rhea-db.org/15801

Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: definition
annotated target: A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
database_cross_reference: PMID:30109646

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482604

PA is hydrolysed to 1-acyl LPA by PLA2[1]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482656

PA is hydrolysed to 1-acyl LPA by PLA2G2A
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482679

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482745

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482759

PS is hydrolyzed to 1-acyl LPS by PLA2[9]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482771

PS is hydrolyzed to 1-acyl LPS by PLA2G2A
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482776

CL is hydrolyzed to MLCL by PLA2G6 (IM)
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482778

PC is hydrolyzed to 1-acyl LPC by PLA2[6]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482816

PI is hydrolyzed to 1-acyl LPI by PLA2[11]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482825

PC is hydrolyzed to 1-acyl LPC by PLA2[5]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482856

PI is hydrolyzed to 1-acyl LPI by PLA2[12]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482868

PE is hydrolyzed to 1-acyl LPE by PLA2[2]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482884

PE is hydrolyzed to 1-acyl LPE by PLA2[3]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482887

PS is hydrolyzed to 2-acyl LPS by PLA2[10]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482897

PG is hydrolyzed to 1-acyl LPG by PLA2[1]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482900

PG is hydrolyzed to 1-acyl LPG by PLA2G2A
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482907

PG is hydrolyzed to 1-acyl LPG by PLA2[16]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602368

PS is hydrolyzed to 1-acyl LPS by PLA2[15]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602374

PI is hydrolyzed to 1-acyl LPI by PLA2[15]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602377

PE is hydrolyzed to 1-acyl LPE by PLA2[16]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602398

PC is hydrolyzed to 1-acyl LPC by PLB1
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602399

PC is hydrolyzed to 1-acyl LPC by PLA2[16]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602417

PA is hydrolyzed to 1-acyl LPA by PLA2[15]
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1602446

PLA2s hydrolyze phospholipids at the Golgi membrane
type: Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848484

Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: lecithinase A activity
database_cross_reference: EC:3.1.1.4

Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: phosphatidase activity
database_cross_reference: EC:3.1.1.4

Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: phosphatidolipase activity
database_cross_reference: EC:3.1.1.4

Axiom
annotated source: A2-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: phosphatidylcholine 2-acylhydrolase activity
database_cross_reference: EC:3.1.1.4

D-type glycerophospholipase activity
type: Class
subclass of: glycerophospholipase activity
subclass of: phosphoric diester hydrolase activity
definition: A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
term tracker item: https://github.com/geneontology/go-ontology/issues/31049
database_cross_reference: EC:3.1.4.4
database_cross_reference: MetaCyc:PHOSCHOL-RXN
database_cross_reference: RHEA:14445
database_cross_reference: Reactome:R-HSA-1483142
database_cross_reference: Reactome:R-HSA-1483182
database_cross_reference: Reactome:R-HSA-2029471
has_exact_synonym: D-type phospholipase activity
has_exact_synonym: phospholipase D activity
has_obo_namespace: molecular_function
has_related_synonym: choline phosphatase activity
has_related_synonym: lecithinase D activity
has_related_synonym: lipophosphodiesterase II activity
has_related_synonym: phosphatidylcholine phosphatidohydrolase activity
id: GO:0004630
in_subset: goslim chembl
narrow match: http://rdf.rhea-db.org/14445

Axiom
annotated source: D-type glycerophospholipase activity
annotated property: definition
annotated target: A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid.
database_cross_reference: PMID:30109646

PC is transphosphatidylated to PG by PLD1-4/6
type: Axiom
annotated source: D-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483142

PC is hydrolyzed to PA and choline by PLD1/2
type: Axiom
annotated source: D-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483182

Hydrolysis of PC to PA by PLD
type: Axiom
annotated source: D-type glycerophospholipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029471

Axiom
annotated source: D-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: choline phosphatase activity
database_cross_reference: EC:3.1.4.4

Axiom
annotated source: D-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: lecithinase D activity
database_cross_reference: EC:3.1.4.4

Axiom
annotated source: D-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: lipophosphodiesterase II activity
database_cross_reference: EC:3.1.4.4

Axiom
annotated source: D-type glycerophospholipase activity
annotated property: has_related_synonym
annotated target: phosphatidylcholine phosphatidohydrolase activity
database_cross_reference: EC:3.1.4.4

sphingomyelin phosphodiesterase activity
type: Class
subclass of: phosphoric diester hydrolase activity
subclass of: lipase activity
definition: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
term tracker item: https://github.com/geneontology/go-ontology/issues/31030
has_alternative_id: GO:0030230
has_alternative_id: GO:0030231
database_cross_reference: EC:3.1.4.12
database_cross_reference: KEGG_REACTION:R02541
database_cross_reference: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
database_cross_reference: RHEA:19253
database_cross_reference: Reactome:R-HSA-1605797
database_cross_reference: Reactome:R-HSA-1606273
database_cross_reference: Reactome:R-HSA-1606288
database_cross_reference: Reactome:R-HSA-1640164
database_cross_reference: Reactome:R-HSA-193706
has_exact_synonym: sphingomyelinase activity
has_obo_namespace: molecular_function
has_related_synonym: sphingomyelin cholinephosphohydrolase activity
id: GO:0004767
in_subset: goslim chembl

Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: definition
annotated target: Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+.
database_cross_reference: EC:3.1.4.12
database_cross_reference: RHEA:19253

SMPD1 hydrolyzes SPHM
type: Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1605797

SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)
type: Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1606273

SMPD4 hydrolyzes sphingomyelin (ER membrane)
type: Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1606288

ENPP7 hydrolyzes sphingomyelin
type: Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1640164

Production of ceramide which can activate JNK and other targets
type: Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-193706

Axiom
annotated source: sphingomyelin phosphodiesterase activity
annotated property: has_related_synonym
annotated target: sphingomyelin cholinephosphohydrolase activity
database_cross_reference: EC:3.1.4.12

sterol ester esterase activity
type: Class
subclass of: lipase activity
definition: Catalysis of the reaction: a sterol ester + H2O = a fatty acid + a sterol + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
database_cross_reference: EC:3.1.1.13
database_cross_reference: MetaCyc:STEROL-ESTERASE-RXN
database_cross_reference: RHEA:10100
database_cross_reference: Reactome:R-HSA-192417
database_cross_reference: Reactome:R-HSA-6813720
database_cross_reference: Reactome:R-HSA-8865667
has_exact_synonym: sterol esterase activity
has_narrow_synonym: cholesterol ester synthase activity
has_narrow_synonym: cholesterol esterase activity
has_obo_namespace: molecular_function
has_related_synonym: acylcholesterol lipase activity
has_related_synonym: cholesterase activity
has_related_synonym: cholesterol ester hydrolase activity
has_related_synonym: cholesteryl ester hydrolase activity
has_related_synonym: cholesteryl ester synthase activity
has_related_synonym: cholesteryl esterase activity
has_related_synonym: sterol ester hydrolase activity
has_related_synonym: steryl-ester acylhydrolase activity
has_related_synonym: triterpenol esterase activity
id: GO:0004771
in_subset: goslim chembl

Axiom
annotated source: sterol ester esterase activity
annotated property: definition
annotated target: Catalysis of the reaction: a sterol ester + H2O = a fatty acid + a sterol + H+.
database_cross_reference: RHEA:10100

Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
type: Axiom
annotated source: sterol ester esterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192417

NCEH1 hydrolyzes cholesterol esters
type: Axiom
annotated source: sterol ester esterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6813720

LIPA hydrolyses sterol esters to sterols and fatty acids
type: Axiom
annotated source: sterol ester esterase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8865667

Axiom
annotated source: sterol ester esterase activity
annotated property: has_narrow_synonym
annotated target: cholesterol ester synthase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_narrow_synonym
annotated target: cholesterol esterase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: acylcholesterol lipase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: cholesterase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: cholesterol ester hydrolase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: cholesteryl ester hydrolase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: cholesteryl ester synthase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: cholesteryl esterase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: sterol ester hydrolase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: steryl-ester acylhydrolase activity
database_cross_reference: EC:3.1.1.13

Axiom
annotated source: sterol ester esterase activity
annotated property: has_related_synonym
annotated target: triterpenol esterase activity
database_cross_reference: EC:3.1.1.13

triacylglycerol lipase activity
type: Class
subclass of: lipase activity
definition: Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/28176
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
database_cross_reference: EC:3.1.1.3
database_cross_reference: MetaCyc:RXN-19278
database_cross_reference: RHEA:12044
database_cross_reference: Reactome:R-HSA-1482777
database_cross_reference: Reactome:R-HSA-163551
database_cross_reference: Reactome:R-HSA-5694109
database_cross_reference: Reactome:R-HSA-8848338
database_cross_reference: Reactome:R-HSA-8848339
has_exact_synonym: TAG activity
has_exact_synonym: triglyceride lipase activity
has_narrow_synonym: heparin releasable hepatic lipase
has_narrow_synonym: hepatic lipase
has_narrow_synonym: hepatic monoacylglycerol acyltransferase
has_narrow_synonym: liver lipase
has_narrow_synonym: post-heparin plasma protamine-resistant lipase
has_narrow_synonym: salt-resistant post-heparin lipase
has_obo_namespace: molecular_function
has_related_synonym: GA 56
has_related_synonym: GEH
has_related_synonym: PPL
has_related_synonym: amano AP
has_related_synonym: amano B
has_related_synonym: amano CE
has_related_synonym: amano CES
has_related_synonym: amano P
has_related_synonym: amno N-AP
has_related_synonym: butyrinase activity
has_related_synonym: cacordase activity
has_related_synonym: capalase L
has_related_synonym: glycerol ester hydrolase activity
has_related_synonym: glycerol-ester hydrolase activity
has_related_synonym: lipazin
has_related_synonym: meito MY 30
has_related_synonym: meito sangyo OF lipase
has_related_synonym: steapsin
has_related_synonym: takedo 1969-4-9
has_related_synonym: triacetinase activity
has_related_synonym: triacylglycerol acylhydrolase activity
has_related_synonym: triacylglycerol ester hydrolase activity
has_related_synonym: tributyrase activity
has_related_synonym: tributyrin esterase activity
has_related_synonym: tributyrinase activity
has_related_synonym: triglyceridase activity
has_related_synonym: triglyceride hydrolase activity
has_related_synonym: triolein hydrolase activity
has_related_synonym: tween hydrolase activity
has_related_synonym: tween-hydrolyzing esterase activity
has_related_synonym: tweenase activity
has_related_synonym: tweenesterase activity
id: GO:0004806
in_subset: goslim chembl
broad match: http://purl.uniprot.org/enzyme/3.1.1.79

Axiom
annotated source: triacylglycerol lipase activity
annotated property: definition
annotated target: Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+.
database_cross_reference: RHEA:12044

TAG is hydrolyzed to DAG by PNPLA2/3
type: Axiom
annotated source: triacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482777

triacylglycerol + H2O -> diacylglycerol + fatty acid
type: Axiom
annotated source: triacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163551

LIPC dimer hydrolyses TAG to DAG and FA
type: Axiom
annotated source: triacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694109

PNPLA4 hydrolyzes TAG
type: Axiom
annotated source: triacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848338

PNPLA5 hydrolyzes TAG
type: Axiom
annotated source: triacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848339

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_exact_synonym
annotated target: TAG activity
database_cross_reference: PMID:16054079

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: heparin releasable hepatic lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: hepatic lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: hepatic monoacylglycerol acyltransferase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: liver lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: post-heparin plasma protamine-resistant lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_narrow_synonym
annotated target: salt-resistant post-heparin lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: GA 56
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: GEH
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: PPL
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amano AP
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amano B
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amano CE
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amano CES
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amano P
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: amno N-AP
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: butyrinase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: cacordase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: capalase L
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: glycerol ester hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: glycerol-ester hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: lipazin
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: meito MY 30
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: meito sangyo OF lipase
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: steapsin
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: takedo 1969-4-9
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triacetinase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triacylglycerol acylhydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triacylglycerol ester hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tributyrase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tributyrin esterase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tributyrinase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triglyceridase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triglyceride hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: triolein hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tween hydrolase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tween-hydrolyzing esterase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tweenase activity
database_cross_reference: EC:3.1.1.3

Axiom
annotated source: triacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: tweenesterase activity
database_cross_reference: EC:3.1.1.3

asialoglycoprotein receptor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
subclass of: Restriction
  on property: has part
  some values from: molecular_function
definition: Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.
has_obo_namespace: molecular_function
id: GO:0004873
in_subset: goslim chembl

Axiom
annotated source: asialoglycoprotein receptor activity
annotated property: definition
annotated target: Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.
database_cross_reference: GOC:bf
database_cross_reference: PMID:11278827
database_cross_reference: PMID:7624395
database_cross_reference: Wikipedia:Asialoglycoprotein

G protein-coupled receptor activity
type: Class
subclass of: signaling receptor activity
subclass of: Restriction
  on property: part of
  some values from: signal transduction
definition: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
has_alternative_id: GO:0001622
has_alternative_id: GO:0001623
has_alternative_id: GO:0001624
has_alternative_id: GO:0001625
has_alternative_id: GO:0016526
database_cross_reference: Reactome:R-HSA-114552
database_cross_reference: Reactome:R-HSA-114558
database_cross_reference: Reactome:R-HSA-167408
database_cross_reference: Reactome:R-HSA-381706
database_cross_reference: Wikipedia:GPCR
has_exact_synonym: G protein coupled receptor activity
has_exact_synonym: G protein linked receptor activity
has_exact_synonym: G-protein coupled receptor activity
has_exact_synonym: G-protein linked receptor activity
has_exact_synonym: GPCR activity
has_exact_synonym: ligand-dependent GPCR activity
has_exact_synonym: receptor activity, G-protein coupled
has_narrow_synonym: EBV-induced receptor
has_narrow_synonym: Epstein-Barr Virus-induced receptor activity
has_narrow_synonym: G-protein coupled receptor activity, unknown ligand
has_narrow_synonym: Mas proto-oncogene receptor activity
has_narrow_synonym: RDC1 receptor activity
has_narrow_synonym: SREB receptor
has_narrow_synonym: orphan G protein coupled receptor activity
has_narrow_synonym: orphan G-protein coupled receptor activity
has_narrow_synonym: orphan GPCR activity
has_narrow_synonym: super conserved receptor expressed in brain receptor activity
has_obo_namespace: molecular_function
id: GO:0004930
in_subset: goslim chembl

Axiom
annotated source: G protein-coupled receptor activity
annotated property: definition
annotated target: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
database_cross_reference: GOC:bf
database_cross_reference: Wikipedia:GPCR

Thrombin-activated PARs activate G12/13
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114552

Thrombin-activated PARs activate Gq
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114558

The high affinity receptor complex binds to G-protein
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-167408

GLP1R:GLP1 activates G(s)
type: Axiom
annotated source: G protein-coupled receptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381706

Axiom
annotated source: G protein-coupled receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity, G-protein coupled
database_cross_reference: GOC:bf

scavenger receptor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: vesicle-mediated transport
subclass of: Restriction
  on property: has part
  some values from: molecular_function
definition: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
has_narrow_synonym: macrophage receptor activity
has_obo_namespace: molecular_function
id: GO:0005044
in_subset: goslim chembl
comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.

Axiom
annotated source: scavenger receptor activity
annotated property: definition
annotated target: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
database_cross_reference: GOC:bf
database_cross_reference: PMID:11790542
database_cross_reference: PMID:12379907
database_cross_reference: PMID:12621157
database_cross_reference: PMID:20981357

guanyl-nucleotide exchange factor activity
type: Class
subclass of: enzyme regulator activity
definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
term tracker item: https://github.com/geneontology/go-ontology/issues/18749
term tracker item: https://github.com/geneontology/go-ontology/issues/18750
term tracker item: https://github.com/geneontology/go-ontology/issues/27684
has_alternative_id: GO:0005086
has_alternative_id: GO:0005087
has_alternative_id: GO:0005088
has_alternative_id: GO:0005089
has_alternative_id: GO:0005090
has_alternative_id: GO:0008321
has_alternative_id: GO:0008433
has_alternative_id: GO:0016219
has_alternative_id: GO:0016220
has_alternative_id: GO:0017034
has_alternative_id: GO:0017112
has_alternative_id: GO:0017132
has_alternative_id: GO:0019839
has_alternative_id: GO:0030676
database_cross_reference: Reactome:R-HSA-109807
database_cross_reference: Reactome:R-HSA-109817
database_cross_reference: Reactome:R-HSA-114544
database_cross_reference: Reactome:R-HSA-1168636
database_cross_reference: Reactome:R-HSA-1225951
database_cross_reference: Reactome:R-HSA-1225957
database_cross_reference: Reactome:R-HSA-1250383
database_cross_reference: Reactome:R-HSA-1250463
database_cross_reference: Reactome:R-HSA-1250498
database_cross_reference: Reactome:R-HSA-1306972
database_cross_reference: Reactome:R-HSA-1433415
database_cross_reference: Reactome:R-HSA-1433471
database_cross_reference: Reactome:R-HSA-156913
database_cross_reference: Reactome:R-HSA-169904
database_cross_reference: Reactome:R-HSA-170979
database_cross_reference: Reactome:R-HSA-171026
database_cross_reference: Reactome:R-HSA-177938
database_cross_reference: Reactome:R-HSA-177945
database_cross_reference: Reactome:R-HSA-180687
database_cross_reference: Reactome:R-HSA-186834
database_cross_reference: Reactome:R-HSA-187746
database_cross_reference: Reactome:R-HSA-194518
database_cross_reference: Reactome:R-HSA-2029445
database_cross_reference: Reactome:R-HSA-2029451
database_cross_reference: Reactome:R-HSA-2029467
database_cross_reference: Reactome:R-HSA-203977
database_cross_reference: Reactome:R-HSA-205039
database_cross_reference: Reactome:R-HSA-210977
database_cross_reference: Reactome:R-HSA-2179407
database_cross_reference: Reactome:R-HSA-2424476
database_cross_reference: Reactome:R-HSA-2424477
database_cross_reference: Reactome:R-HSA-2485180
database_cross_reference: Reactome:R-HSA-2730840
database_cross_reference: Reactome:R-HSA-350769
database_cross_reference: Reactome:R-HSA-354173
database_cross_reference: Reactome:R-HSA-379044
database_cross_reference: Reactome:R-HSA-379048
database_cross_reference: Reactome:R-HSA-380073
database_cross_reference: Reactome:R-HSA-381727
database_cross_reference: Reactome:R-HSA-389348
database_cross_reference: Reactome:R-HSA-389350
database_cross_reference: Reactome:R-HSA-392054
database_cross_reference: Reactome:R-HSA-392195
database_cross_reference: Reactome:R-HSA-3928592
database_cross_reference: Reactome:R-HSA-3928612
database_cross_reference: Reactome:R-HSA-3928628
database_cross_reference: Reactome:R-HSA-3928632
database_cross_reference: Reactome:R-HSA-3928633
database_cross_reference: Reactome:R-HSA-3928642
database_cross_reference: Reactome:R-HSA-3928651
database_cross_reference: Reactome:R-HSA-392870
database_cross_reference: Reactome:R-HSA-3965444
database_cross_reference: Reactome:R-HSA-399938
database_cross_reference: Reactome:R-HSA-399995
database_cross_reference: Reactome:R-HSA-400037
database_cross_reference: Reactome:R-HSA-400092
database_cross_reference: Reactome:R-HSA-4093336
database_cross_reference: Reactome:R-HSA-416530
database_cross_reference: Reactome:R-HSA-416588
database_cross_reference: Reactome:R-HSA-418579

Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: definition
annotated target: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
database_cross_reference: GOC:kd
database_cross_reference: GOC:mah
database_cross_reference: PMID:23303910
database_cross_reference: PMID:27218782

GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109807

GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-109817

p115-RhoGEF activation of RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-114544

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1168636

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225951

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1225957

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250383

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250463

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1250498

RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1306972

Activation of RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433415

Activation of RAS by p-KIT bound SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1433471

Regeneration of eEF1A:GTP by eEF1B activity
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156913

C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-169904

(Frs2)C3G stimulates nucleotide exchange on Rap1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-170979

Guanine nucleotide exchange on RAL
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-171026

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177938

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-177945

Conversion of Ran-GDP to Ran-GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-180687

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-186834

RIT/RIN are activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-187746

RhoA is activated by nucleotide exchange and inhibits axonal growth
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-194518

An unknown GEF exchanges GTP for GDP on CDC42:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029445

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029451

Activation of RAC1 by CRKII:DOCK180:ELMO
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029467

SAR1 Activation And Membrane Binding
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203977

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205039

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-210977

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2179407

Activation of RAC1 by VAV2/3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424476

SOS mediated nucleotide exchange of RAS (SHC)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2424477

MII catalyses GDP/GTP exchange on Gt
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2485180

Activation of RAC1 by VAV
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2730840

trans-Golgi Network Coat Activation
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-350769

Activation of Rap1 by cytosolic GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-354173

Liganded Gs-activating GPCR acts as a GEF for Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379044

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379048

Liganded Gi-activating GPCR acts as a GEF for Gi
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-380073

RAP1A exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381727

Activation of Rac1 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389348

Activation of Cdc42 by pVav1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389350

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392054

Gi activation by P2Y purinoceptor 12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392195

p190RhoGEF exchanges GTP for GDP on RHOA, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928592

KALRN exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928612

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928628

ITSN1 exchanges GTP for GDP on CDC42, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928632

bPIX exchanges GTP for GDP on RAC, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928633

TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928642

NGEF exchanges GTP for GDP on RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3928651

Gs activation by prostacyclin receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-392870

WNT:FZD complex promotes G-protein nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3965444

Activation of Rac1 by FARP2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399938

Muscarinic Acetylcholine Receptor M3 activates Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-399995

Gi,Go Heterotrimeric G-protein complex dissociates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400037

Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-400092

p-TIAM1 exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4093336

FFAR1:FFAR1 ligands activate Gq
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416530

Activation of Rho by LARG and PDZ-RhoGEF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-416588

Gq activation by P2Y purinoceptor 1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418579

Activation of Cdc42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418850

Activation of Rac1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-418856

GEFs activate RhoA,B,C
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-419166

Opsins act as GEFs for G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-420883

Activation of RAC1 by SOS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428535

Gq activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428750

G13 activation by TP receptor
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-428917

VAV1 is a GEF for Rho/Rac family GTPases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442273

VAV2 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442291

VAV3 is a GEF for Rho/Rac family kinases
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442314

NMDA-activated RASGRF1 activates RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-442732

Activation of Rac1 by VAV2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-445064

VEGF induces CDC42 activation by unknown mechanism
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218829

DOCK180:ELMO exchanges GTP for GDP, activating RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218839

VAV exchanges GTP for GDP on RAC1, activating it
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5218850

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5617816

GBF1 stimulates nucleotide exchange on ARF4
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623508

RAB3IP stimulates nucleotide exchange on RAB8A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5623521

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637806

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5637808

Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654392

Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654402

Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654413

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654426

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654600

Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654618

Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654647

Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5654663

Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655241

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655277

Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655326

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655347

RAS GEFs promote RAS nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5672965

GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686071

GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5686318

Nucleotide exchange on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694409

GBF1 stimulates ARF nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6807868

GBF1 stimulates nucleotide exchange on ARF
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811414

ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811418

RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6811429

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-749453

Liganded G12/13-activating GPCR acts as a GEF for G12/13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-751029

Glucagon:GCGR mediates GTP-GDP exchange
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-825631

Activation of RAC1 by the PXN:CRK complex
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848618

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8850041

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851827

RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851877

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851899

RAB3 GEFs exchange GTP for GDP on RAB3A
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875318

RAB5 GEFs exchange GTP for GDP on RAB5
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875320

RAPGEF1 activates RAP1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875568

DOCK7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8875591

DENND4s exchange GTP for GDP on RAB10
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876188

RAB8 GEFs exchange GTP for GDP on RAB8
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876190

RAB9 GEFs exchange GTP for GDP on RAB9
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876191

RIC1-RGP1 exchanges GTP for GDP on RAB6
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876193

DENND3 exchanges GTP for GDP on RAB12
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876454

RAB13 GEFs exchange GTP for GDP on RAB13
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876615

DENND6A,B exchange GTP for GDP on RAB14
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876616

RAB21 GEFs exchange GTP for GDP on RAB21
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8876837

MADD exchanges GTP for GDP on RAB27
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877308

RAB31 GEFs exchange GTP for GDP on RAB31
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877311

MON1:CCZ1 exchanges GTP for GDP on RAB7
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877451

TRAPPC complexes exchange GTP for GDP on RAB1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877475

DENND1s exchange GTP for GDP on RAB35
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877612

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877760

DENND5A,B exchange GTP for GDP on RAB39
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877813

RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8877998

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8964604

RHOA GEFs activate RHOA
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8980691

Opsins binds G alpha-t
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982637

G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8982640

RHOB GEFs activate RHOB
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013023

RHOC GEFs activate RHOC
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013109

RAC1 GEFs activate RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013143

CDC42 GEFs activate CDC42
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013159

RHOD auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9013435

RAC2 GEFs activate RAC2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014296

RHOG GEFs activate RHOG
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9014433

RHOJ GEFs activate RHOJ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9017491

RHOQ GEFs activate RHOQ
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018747

RHOU auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018768

RAC3 GEFs activate RAC3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018804

RHOT1 GEFs activate RHOT1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018817

RHOT2 GEFs activate RHOT2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018825

NTRK2 activates RAS signaling through SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026891

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9029158

NTRK2 activates RAS signaling through FRS2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032067

DOCK3 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9032798

NTRK2 and CDK5 promote activation of RAC1 by TIAM1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033292

ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9036301

Activation of Rap1 by membrane-associated GEFs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-939265

SOS1-mediated nucleotide exchange of RAS downstream of FLT3
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9607304

p-S516-ARHGEF7 activates RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9619803

RCC1 stimulates GDP to GTP exchange on RAN
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9624845

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9634418

RRAGC,D exchanges GTP for GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9639286

RRAGA,B exchanges GDP for GTP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9640167

ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9660824

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9664991

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665009

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665404

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665408

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665700

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9665707

DOCK180 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666428

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9666430

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9670436

SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672163

SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9672170

CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9680385

RHOF auto-activates
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693111

FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9695853

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9703441

p-VAV1,2,3 exchange 6TGTP for GDP on RAC1
type: Axiom
annotated source: guanyl-nucleotide exchange factor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9751201

signaling receptor binding
type: Class
subclass of: protein binding
definition: Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
has_broad_synonym: receptor binding
database_cross_reference: Wikipedia:Ligand_(biochemistry)
has_narrow_synonym: receptor ligand
has_obo_namespace: molecular_function
has_related_synonym: receptor-associated protein activity
id: GO:0005102
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim plant
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.

Axiom
annotated source: signaling receptor binding
annotated property: definition
annotated target: Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ceb
database_cross_reference: ISBN:0198506732

frizzled binding
type: Class
subclass of: signaling receptor binding
definition: Binding to a frizzled (fz) receptor.
has_alternative_id: GO:0005110
has_exact_synonym: fz binding
has_narrow_synonym: frizzled ligand
has_narrow_synonym: frizzled-2 binding
has_narrow_synonym: frizzled-2 ligand
has_narrow_synonym: fz ligand
has_narrow_synonym: fz2 binding
has_narrow_synonym: fz2 ligand
has_obo_namespace: molecular_function
id: GO:0005109
in_subset: goslim chembl

Axiom
annotated source: frizzled binding
annotated property: definition
annotated target: Binding to a frizzled (fz) receptor.
database_cross_reference: GOC:ceb

death receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
has_narrow_synonym: APO binding
has_narrow_synonym: DR binding
has_narrow_synonym: EDAR binding
has_narrow_synonym: FAS binding
has_narrow_synonym: KILLER binding
has_narrow_synonym: NGFR binding
has_narrow_synonym: TNFR1 binding
has_narrow_synonym: TRAIL binding
has_narrow_synonym: death receptor ligand
has_obo_namespace: molecular_function
has_related_synonym: death receptor adaptor protein activity
has_related_synonym: death receptor interacting protein activity
has_related_synonym: death receptor-associated factor activity
id: GO:0005123
in_subset: goslim chembl

Axiom
annotated source: death receptor binding
annotated property: definition
annotated target: Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
database_cross_reference: GOC:ceb
database_cross_reference: GOC:rl
database_cross_reference: PMID:15654015

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: APO binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: DR binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: EDAR binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: FAS binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: KILLER binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: NGFR binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: TNFR1 binding
database_cross_reference: GOC:rl

Axiom
annotated source: death receptor binding
annotated property: has_narrow_synonym
annotated target: TRAIL binding
database_cross_reference: GOC:rl

cytokine activity
type: Class
subclass of: receptor ligand activity
definition: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
term tracker item: https://github.com/geneontology/go-ontology/issues/19116
term tracker item: https://github.com/geneontology/go-ontology/issues/29424
has_narrow_synonym: phytocytokine activity
has_obo_namespace: molecular_function
has_related_synonym: autocrine activity
has_related_synonym: paracrine activity
id: GO:0005125
in_subset: goslim chembl

Axiom
annotated source: cytokine activity
annotated property: definition
annotated target: The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.
database_cross_reference: ISBN:0198599471
database_cross_reference: PMID:11530802

Axiom
annotated source: cytokine activity
annotated property: has_narrow_synonym
annotated target: phytocytokine activity
database_cross_reference: PMID:23072994

Axiom
annotated source: cytokine activity
annotated property: has_related_synonym
annotated target: autocrine activity
database_cross_reference: GOC:rl

Axiom
annotated source: cytokine activity
annotated property: has_related_synonym
annotated target: paracrine activity
database_cross_reference: GOC:rl

interleukin-5 receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to an interleukin-5 receptor.
has_narrow_synonym: IL-5
has_narrow_synonym: interleukin-5 receptor ligand
has_obo_namespace: molecular_function
id: GO:0005137
in_subset: goslim chembl

Axiom
annotated source: interleukin-5 receptor binding
annotated property: definition
annotated target: Binding to an interleukin-5 receptor.
database_cross_reference: GOC:ai

interleukin-6 receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to an interleukin-6 receptor.
has_narrow_synonym: IL-6
has_narrow_synonym: interleukin-6 receptor ligand
has_obo_namespace: molecular_function
id: GO:0005138
in_subset: goslim chembl

Axiom
annotated source: interleukin-6 receptor binding
annotated property: definition
annotated target: Binding to an interleukin-6 receptor.
database_cross_reference: GOC:ai

interleukin-8 receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to an interleukin-8 receptor.
has_narrow_synonym: IL-8
has_narrow_synonym: interleukin-8 receptor ligand
has_obo_namespace: molecular_function
id: GO:0005153
in_subset: goslim chembl

Axiom
annotated source: interleukin-8 receptor binding
annotated property: definition
annotated target: Binding to an interleukin-8 receptor.
database_cross_reference: GOC:go_curators

epidermal growth factor receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to an epidermal growth factor receptor.
has_alternative_id: GO:0008185
has_exact_synonym: EGF receptor binding
has_exact_synonym: EGFR binding
has_exact_synonym: TGF-alpha receptor binding
has_exact_synonym: TGFalpha receptor binding
has_exact_synonym: transforming growth factor alpha receptor binding
has_narrow_synonym: EGF
has_narrow_synonym: EGF receptor ligand
has_narrow_synonym: epidermal growth factor
has_narrow_synonym: epidermal growth factor receptor ligand
has_narrow_synonym: transforming growth factor alpha
has_narrow_synonym: transforming growth factor alpha receptor ligand
has_obo_namespace: molecular_function
id: GO:0005154
in_subset: goslim chembl

Axiom
annotated source: epidermal growth factor receptor binding
annotated property: definition
annotated target: Binding to an epidermal growth factor receptor.
database_cross_reference: GOC:ai

tumor necrosis factor receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to a tumor necrosis factor receptor.
has_exact_synonym: TNF receptor binding
has_narrow_synonym: tumor necrosis factor
has_narrow_synonym: tumor necrosis factor receptor ligand
has_obo_namespace: molecular_function
id: GO:0005164
in_subset: goslim chembl

Axiom
annotated source: tumor necrosis factor receptor binding
annotated property: definition
annotated target: Binding to a tumor necrosis factor receptor.
database_cross_reference: GOC:ai

integrin binding
type: Class
subclass of: signaling receptor binding
subclass of: protein-containing complex binding
definition: Binding to an integrin.
has_narrow_synonym: integrin ligand
has_obo_namespace: molecular_function
id: GO:0005178
in_subset: goslim chembl

Axiom
annotated source: integrin binding
annotated property: definition
annotated target: Binding to an integrin.
database_cross_reference: GOC:ceb

hormone activity
type: Class
subclass of: receptor ligand activity
definition: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
has_narrow_synonym: cAMP generating peptide activity
has_narrow_synonym: glycopeptide hormone
has_narrow_synonym: lipopeptide hormone
has_narrow_synonym: peptide hormone
has_obo_namespace: molecular_function
id: GO:0005179
in_subset: goslim chembl
comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.

Axiom
annotated source: hormone activity
annotated property: definition
annotated target: The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

neuropeptide hormone activity
type: Class
subclass of: hormone activity
subclass of: Restriction
  on property: has part
  some values from: signaling receptor binding
definition: The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
database_cross_reference: Wikipedia:Neurohormone
has_exact_synonym: neurohormone
has_obo_namespace: molecular_function
id: GO:0005184
in_subset: goslim chembl

Axiom
annotated source: neuropeptide hormone activity
annotated property: definition
annotated target: The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
database_cross_reference: GOC:mah

structural molecule activity
type: Class
subclass of: molecular_function
definition: The action of a molecule that contributes to the structural integrity of a complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/24130
has_obo_namespace: molecular_function
id: GO:0005198
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: structural molecule activity
annotated property: definition
annotated target: The action of a molecule that contributes to the structural integrity of a complex.
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

transporter activity
type: Class
subclass of: molecular_function
definition: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
term tracker item: https://github.com/geneontology/go-ontology/issues/27621
has_alternative_id: GO:0005478
has_obo_namespace: molecular_function
has_related_synonym: carrier
id: GO:0005215
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.

Axiom
annotated source: transporter activity
annotated property: definition
annotated target: Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dgf

SNAP receptor activity
type: Class
subclass of: protein-macromolecule adaptor activity
subclass of: Restriction
  on property: part of
  some values from: membrane organization
definition: Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
has_alternative_id: GO:0005485
has_alternative_id: GO:0005486
has_exact_synonym: SNARE
has_narrow_synonym: Q-SNARE activity
has_narrow_synonym: R-SNARE activity
has_narrow_synonym: SNAP-25
has_narrow_synonym: t-SNARE activity
has_narrow_synonym: v-SNARE activity
has_obo_namespace: molecular_function
id: GO:0005484
in_subset: goslim chembl

Axiom
annotated source: SNAP receptor activity
annotated property: definition
annotated target: Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
database_cross_reference: GOC:mah
database_cross_reference: PMID:14570579

protein binding
type: Class
subclass of: molecular_function
definition: Binding to a protein.
has_alternative_id: GO:0001948
has_alternative_id: GO:0045308
database_cross_reference: Reactome:R-HSA-9866132
has_exact_synonym: protein amino acid binding
has_narrow_synonym: glycoprotein binding
has_obo_namespace: molecular_function
id: GO:0005515
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon

Axiom
annotated source: protein binding
annotated property: definition
annotated target: Binding to a protein.
database_cross_reference: GOC:go_curators

Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
type: Axiom
annotated source: protein binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9866132

calmodulin binding
type: Class
subclass of: protein binding
definition: Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
database_cross_reference: Reactome:R-HSA-202110
has_obo_namespace: molecular_function
id: GO:0005516
in_subset: goslim chembl

Axiom
annotated source: calmodulin binding
annotated property: definition
annotated target: Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
database_cross_reference: GOC:krc

eNOS:Caveolin-1 complex binds to CaM
type: Axiom
annotated source: calmodulin binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-202110

insulin-like growth factor binding
type: Class
subclass of: growth factor binding
definition: Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
has_exact_synonym: IGF binding
has_obo_namespace: molecular_function
id: GO:0005520
in_subset: goslim chembl

Axiom
annotated source: insulin-like growth factor binding
annotated property: definition
annotated target: Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
database_cross_reference: ISBN:0198506732

D-mannose binding
type: Class
subclass of: carbohydrate binding
definition: Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
has_broad_synonym: mannose binding
database_cross_reference: Reactome:R-HSA-947991
has_obo_namespace: molecular_function
has_related_synonym: mannose binding lectin
id: GO:0005537
in_subset: goslim chembl

Axiom
annotated source: D-mannose binding
annotated property: definition
annotated target: Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0192800981

Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi
type: Axiom
annotated source: D-mannose binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-947991

glycosaminoglycan binding
type: Class
subclass of: molecular_function
definition: Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
has_obo_namespace: molecular_function
id: GO:0005539
in_subset: goslim chembl

Axiom
annotated source: glycosaminoglycan binding
annotated property: definition
annotated target: Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

cellular_component
type: Class
definition: A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
term tracker item: https://github.com/geneontology/go-ontology/issues/17729
has_alternative_id: GO:0008372
database_cross_reference: NIF_Subcellular:sao1337158144
has_exact_synonym: cell or subcellular entity
has_exact_synonym: cellular component
has_obo_namespace: cellular_component
has_related_synonym: subcellular entity
id: GO:0005575
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: cellular_component
annotated property: definition
annotated target: A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
database_cross_reference: GOC:pdt

Axiom
annotated source: cellular_component
annotated property: has_related_synonym
annotated target: subcellular entity
database_cross_reference: NIF_Subcellular:nlx_subcell_100315

extracellular region
type: Class
subclass of: cellular_component
definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: Wikipedia:Extracellular
has_exact_synonym: extracellular
has_obo_namespace: cellular_component
id: GO:0005576
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.

Axiom
annotated source: extracellular region
annotated property: definition
annotated target: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
database_cross_reference: GOC:go_curators

extracellular space
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: extracellular region
definition: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: NIF_Subcellular:sao1425028079
has_obo_namespace: cellular_component
has_related_synonym: intercellular space
id: GO:0005615
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

Axiom
annotated source: extracellular space
annotated property: definition
annotated target: That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
database_cross_reference: ISBN:0198547684

cell wall
type: Class
subclass of: external encapsulating structure
definition: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/21669
database_cross_reference: Wikipedia:Cell_wall
has_obo_namespace: cellular_component
id: GO:0005618
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995).

Axiom
annotated source: cell wall
annotated property: definition
annotated target: The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:15134259
database_cross_reference: Wikipedia:Microbial_cyst

intracellular anatomical structure
type: Class
subclass of: cellular_component
definition: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
term tracker item: https://github.com/geneontology/go-ontology/issues/17776
database_cross_reference: Wikipedia:Intracellular
has_exact_synonym: internal to cell
has_exact_synonym: intracellular
has_exact_synonym: protoplasm
has_obo_namespace: cellular_component
has_related_synonym: nucleocytoplasm
has_related_synonym: protoplast
id: GO:0005622
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim plant

Axiom
annotated source: intracellular anatomical structure
annotated property: definition
annotated target: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: intracellular anatomical structure
annotated property: has_related_synonym
annotated target: nucleocytoplasm
database_cross_reference: GOC:mah

Axiom
annotated source: intracellular anatomical structure
annotated property: has_related_synonym
annotated target: protoplast
database_cross_reference: GOC:mah

nucleus
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: nucleus
annotated property: definition
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:go_curators

Axiom
annotated source: nucleus
annotated property: has_narrow_synonym
annotated target: horsetail nucleus
database_cross_reference: GOC:al
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:15030757

nuclear envelope
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport.
term tracker item: https://github.com/geneontology/go-ontology/issues/29832
has_alternative_id: GO:0005636
database_cross_reference: Wikipedia:Nuclear_envelope
has_obo_namespace: cellular_component
id: GO:0005635
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: nuclear envelope
annotated property: definition
annotated target: The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport.
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16164970

nucleoplasm
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: That part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: NIF_Subcellular:sao661522542
database_cross_reference: Wikipedia:Nucleoplasm
has_obo_namespace: cellular_component
id: GO:0005654
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: nucleoplasm
annotated property: definition
annotated target: That part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: GOC:ma
database_cross_reference: ISBN:0124325653

chromosome
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: Wikipedia:Chromosome
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
id: GO:0005694
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.

Axiom
annotated source: chromosome
annotated property: definition
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684

nucleolus
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: nucleus
definition: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
id: GO:0005730
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: nucleolus
annotated property: definition
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732

cytoplasm
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
term tracker item: https://github.com/geneontology/go-ontology/issues/23023
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
id: GO:0005737
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cytoplasm
annotated property: definition
annotated target: The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684

mitochondrion
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_exact_synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

Axiom
annotated source: mitochondrion
annotated property: definition
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:giardia
database_cross_reference: ISBN:0198506732

lysosome
type: Class
subclass of: vacuole
definition: A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: NIF_Subcellular:sao585356902
database_cross_reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
id: GO:0005764
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant

Axiom
annotated source: lysosome
annotated property: definition
annotated target: A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

endosome
type: Class
subclass of: cytoplasmic vesicle
definition: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: NIF_Subcellular:sao1720343330
database_cross_reference: Wikipedia:Endosome
has_obo_namespace: cellular_component
id: GO:0005768
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: endosome
annotated property: definition
annotated target: A vacuole to which materials ingested by endocytosis are delivered.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:19696797

vacuole
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: vacuole
annotated property: definition
annotated target: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

peroxisome
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
has_alternative_id: GO:0019818
has_broad_synonym: peroxisome vesicle
database_cross_reference: NIF_Subcellular:sao499555322
database_cross_reference: Wikipedia:Peroxisome
has_obo_namespace: cellular_component
has_related_synonym: peroxisomal
id: GO:0005777
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: peroxisome
annotated property: definition
annotated target: A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
database_cross_reference: GOC:pm
database_cross_reference: PMID:9302272
database_cross_reference: UniProtKB-KW:KW-0576

endoplasmic reticulum
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: NIF_Subcellular:sao1036339110
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_exact_synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast

Axiom
annotated source: endoplasmic reticulum
annotated property: definition
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: ISBN:0198506732

Golgi apparatus
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
term tracker item: https://github.com/geneontology/go-ontology/issues/14798
has_broad_synonym: Golgi
database_cross_reference: NIF_Subcellular:sao451912436
database_cross_reference: Wikipedia:Golgi_apparatus
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

Axiom
annotated source: Golgi apparatus
annotated property: definition
annotated target: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:9695800

lipid droplet
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
has_exact_synonym: adiposome
has_exact_synonym: lipid body
has_exact_synonym: lipid particle
has_obo_namespace: cellular_component
id: GO:0005811
in_subset: goslim chembl
in_subset: goslim generic
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.

Axiom
annotated source: lipid droplet
annotated property: definition
annotated target: An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

microtubule organizing center
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoskeleton
definition: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: Wikipedia:Microtubule_organizing_center
has_exact_synonym: MTOC
has_exact_synonym: microtubule organising centre
has_obo_namespace: cellular_component
id: GO:0005815
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim yeast

Axiom
annotated source: microtubule organizing center
annotated property: definition
annotated target: An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:17072892
database_cross_reference: PMID:17245416
database_cross_reference: Wikipedia:Microtubule_organizing_center

cytosol
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: NIF_Subcellular:sao101633890
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
id: GO:0005829
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant

Axiom
annotated source: cytosol
annotated property: definition
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:jl

ribosome
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/17777
has_alternative_id: GO:0033279
database_cross_reference: NIF_Subcellular:sao1429207766
database_cross_reference: Wikipedia:Ribosome
has_narrow_synonym: free ribosome
has_narrow_synonym: membrane bound ribosome
has_obo_namespace: cellular_component
has_related_synonym: ribosomal RNA
id: GO:0005840
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: ribosome
annotated property: definition
annotated target: An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
database_cross_reference: ISBN:0198506732

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: free ribosome
database_cross_reference: NIF_Subcellular:sao1139385046

Axiom
annotated source: ribosome
annotated property: has_narrow_synonym
annotated target: membrane bound ribosome
database_cross_reference: NIF_Subcellular:sao1291545653

cytoskeleton
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
id: GO:0005856
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton
annotated property: definition
annotated target: A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16959967
database_cross_reference: PMID:27419875

plasma membrane
type: Class
subclass of: membrane
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
has_alternative_id: GO:0005887
has_alternative_id: GO:0005904
has_broad_synonym: juxtamembrane
database_cross_reference: NIF_Subcellular:sao1663586795
database_cross_reference: Wikipedia:Cell_membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_exact_synonym: cytoplasmic membrane
has_exact_synonym: plasmalemma
has_narrow_synonym: bacterial inner membrane
has_narrow_synonym: inner endospore membrane
has_narrow_synonym: integral component of plasma membrane
has_narrow_synonym: integral to plasma membrane
has_narrow_synonym: plasma membrane lipid bilayer
has_obo_namespace: cellular_component
id: GO:0005886
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: plasma membrane
annotated property: definition
annotated target: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: ISBN:0716731363

Axiom
annotated source: plasma membrane
annotated property: has_exact_synonym
annotated target: cellular membrane
database_cross_reference: NIF_Subcellular:sao6433132645

Axiom
annotated source: plasma membrane
annotated property: has_narrow_synonym
annotated target: plasma membrane lipid bilayer
database_cross_reference: GOC:mah

cilium
type: Class
subclass of: organelle
subclass of: Restriction
  on property: has part
  some values from: membrane
subclass of: Restriction
  on property: has part
  some values from: protein-containing complex
definition: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
has_alternative_id: GO:0072372
database_cross_reference: FMA:67181
database_cross_reference: NIF_Subcellular:sao787716553
database_cross_reference: Wikipedia:Cilium
has_exact_synonym: eukaryotic flagellum
has_exact_synonym: microtubule-based flagellum
has_narrow_synonym: primary cilium
has_obo_namespace: cellular_component
has_related_synonym: flagellum
id: GO:0005929
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.

Axiom
annotated source: cilium
annotated property: definition
annotated target: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
database_cross_reference: GOC:cilia
database_cross_reference: GOC:curators
database_cross_reference: GOC:kmv
database_cross_reference: GOC:vw
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16824949
database_cross_reference: PMID:17009929
database_cross_reference: PMID:20144998

carbohydrate metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
term tracker item: https://github.com/geneontology/go-ontology/issues/22880
created by: jl
creation date: 2012-10-23T15:40:34Z
has_alternative_id: GO:0044261
has_alternative_id: GO:0044723
database_cross_reference: Reactome:R-HSA-71387
database_cross_reference: Wikipedia:Carbohydrate_metabolism
has_exact_synonym: carbohydrate metabolism
has_obo_namespace: biological_process
id: GO:0005975
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: carbohydrate metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

Metabolism of carbohydrates
type: Axiom
annotated source: carbohydrate metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-71387

generation of precursor metabolites and energy
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
has_broad_synonym: energy pathways
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
has_related_synonym: metabolic energy generation
id: GO:0006091
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
database_cross_reference: GOC:jl

Axiom
annotated source: generation of precursor metabolites and energy
annotated property: has_related_synonym
annotated target: intermediary metabolism
database_cross_reference: GOC:mah

DNA metabolic process
type: Class
subclass of: metabolic process
definition: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
has_alternative_id: GO:0055132
has_exact_synonym: DNA metabolism
has_exact_synonym: cellular DNA metabolism
has_obo_namespace: biological_process
id: GO:0006259
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote ribbon

Axiom
annotated source: DNA metabolic process
annotated property: definition
annotated target: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
database_cross_reference: ISBN:0198506732

mRNA processing
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: part of
  some values from: biosynthetic process
definition: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
has_obo_namespace: biological_process
has_related_synonym: mRNA maturation
id: GO:0006397
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: mRNA processing
annotated property: definition
annotated target: Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
database_cross_reference: GOC:mah

tRNA metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
has_exact_synonym: tRNA metabolism
has_obo_namespace: biological_process
id: GO:0006399
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe

Axiom
annotated source: tRNA metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
database_cross_reference: ISBN:0198506732

translation
type: Class
subclass of: biosynthetic process
subclass of: Restriction
  on property: part of
  some values from: biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: biosynthetic process
subclass of: Restriction
  on property: has part
  some values from: acyltransferase activity
subclass of: Restriction
  on property: has part
  some values from: protein-RNA complex assembly
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
database_cross_reference: Reactome:R-HSA-72766
database_cross_reference: Wikipedia:Translation_(genetics)
has_exact_synonym: protein translation
has_obo_namespace: biological_process
id: GO:0006412
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: translation
annotated property: definition
annotated target: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: GOC:go_curators

Translation
type: Axiom
annotated source: translation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-72766

protein folding
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: protein maturation
definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
term tracker item: https://github.com/geneontology/go-ontology/issues/25673
has_alternative_id: GO:0007022
has_alternative_id: GO:0007024
has_alternative_id: GO:0007025
database_cross_reference: Reactome:R-HSA-389960
database_cross_reference: Reactome:R-HSA-390466
database_cross_reference: Reactome:R-HSA-532668
database_cross_reference: Wikipedia:Protein_folding
has_narrow_synonym: alpha-tubulin folding
has_narrow_synonym: beta-tubulin folding
has_narrow_synonym: chaperonin-mediated tubulin folding
has_obo_namespace: biological_process
has_related_synonym: chaperone activity
has_related_synonym: chaperonin ATPase activity
has_related_synonym: co-chaperone activity
has_related_synonym: co-chaperonin activity
has_related_synonym: glycoprotein-specific chaperone activity
has_related_synonym: non-chaperonin molecular chaperone ATPase activity
has_related_synonym: protein complex assembly, multichaperone pathway
id: GO:0006457
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: protein folding
annotated property: definition
annotated target: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:rb

Formation of tubulin folding intermediates by CCT/TriC
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-389960

Chaperonin-mediated protein folding
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390466

N-glycan trimming in the ER and Calnexin/Calreticulin cycle
type: Axiom
annotated source: protein folding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-532668

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: alpha-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: beta-tubulin folding
database_cross_reference: GOC:mah

Axiom
annotated source: protein folding
annotated property: has_narrow_synonym
annotated target: chaperonin-mediated tubulin folding
database_cross_reference: GOC:mah

proteolysis
type: Class
subclass of: metabolic process
definition: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
database_cross_reference: Wikipedia:Proteolysis
has_exact_synonym: peptidolysis
has_narrow_synonym: ATP-dependent proteolysis
has_obo_namespace: biological_process
id: GO:0006508
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.

Axiom
annotated source: proteolysis
annotated property: definition
annotated target: The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah

Axiom
annotated source: proteolysis
annotated property: has_narrow_synonym
annotated target: ATP-dependent proteolysis
database_cross_reference: GOC:mah

amino acid metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
term tracker item: https://github.com/geneontology/go-ontology/issues/17904
has_alternative_id: GO:0006519
has_exact_synonym: cellular amino acid metabolic process
has_exact_synonym: cellular amino acid metabolism
has_obo_namespace: biological_process
has_related_synonym: amino acid and derivative metabolism
has_related_synonym: cellular amino acid and derivative metabolic process
id: GO:0006520
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: amino acid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
database_cross_reference: ISBN:0198506732

protein targeting
type: Class
subclass of: biological_process
definition: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
term tracker item: https://github.com/geneontology/go-ontology/issues/26248
database_cross_reference: Wikipedia:Protein_targeting
has_narrow_synonym: protein sorting along secretory pathway
has_obo_namespace: biological_process
has_related_synonym: nascent polypeptide association
id: GO:0006605
in_subset: goslim chembl
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: protein targeting
annotated property: definition
annotated target: The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
database_cross_reference: GOC:ma

lipid metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: Reactome:R-HSA-556833
database_cross_reference: Wikipedia:Lipid_metabolism
has_exact_synonym: lipid metabolism
has_obo_namespace: biological_process
id: GO:0006629
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
database_cross_reference: GOC:ma

Metabolism of lipids
type: Axiom
annotated source: lipid metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-556833

sulfur compound metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: Wikipedia:Sulfur_metabolism
has_exact_synonym: sulfur metabolism
has_exact_synonym: sulphur metabolic process
has_exact_synonym: sulphur metabolism
has_obo_namespace: biological_process
id: GO:0006790
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: sulfur compound metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
database_cross_reference: GOC:ai

xenobiotic metabolic process
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: part of
  some values from: cellular response to xenobiotic stimulus
definition: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
term tracker item: https://github.com/geneontology/go-ontology/issues/19460
has_alternative_id: GO:0017144
database_cross_reference: Reactome:R-HSA-211859
database_cross_reference: Reactome:R-HSA-211981
database_cross_reference: Reactome:R-HSA-2161541
database_cross_reference: Reactome:R-HSA-9748784
database_cross_reference: Wikipedia:Drug_metabolism
database_cross_reference: Wikipedia:Xenobiotic_metabolism
has_exact_synonym: xenobiotic metabolism
has_obo_namespace: biological_process
has_related_synonym: drug metabolic process
has_related_synonym: drug metabolism
id: GO:0006805
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: xenobiotic metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
database_cross_reference: GOC:cab2
database_cross_reference: GOC:krc

Biological oxidations
type: Axiom
annotated source: xenobiotic metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-211859

Xenobiotics
type: Axiom
annotated source: xenobiotic metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-211981

Abacavir metabolism
type: Axiom
annotated source: xenobiotic metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161541

Drug ADME
type: Axiom
annotated source: xenobiotic metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9748784

transport
type: Class
subclass of: biological_process
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/20292
created by: jl
creation date: 2012-12-13T16:25:32Z
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
has_alternative_id: GO:0044765
database_cross_reference: Reactome:R-HSA-382551
has_obo_namespace: biological_process
has_related_synonym: single-organism transport
id: GO:0006810
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.

Axiom
annotated source: transport
annotated property: definition
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
database_cross_reference: GOC:dos
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Transport of small molecules
type: Axiom
annotated source: transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382551

nucleocytoplasmic transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
definition: The directed movement of molecules between the nucleus and the cytoplasm.
has_alternative_id: GO:0000063
has_narrow_synonym: nucleocytoplasmic shuttling
has_obo_namespace: biological_process
id: GO:0006913
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pombe
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.

Axiom
annotated source: nucleocytoplasmic transport
annotated property: definition
annotated target: The directed movement of molecules between the nucleus and the cytoplasm.
database_cross_reference: GOC:go_curators

autophagy
type: Class
subclass of: catabolic process
subclass of: Restriction
  on property: has part
  some values from: transmembrane transport
definition: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
term tracker item: https://github.com/geneontology/go-ontology/issues/25541
has_alternative_id: GO:0016238
database_cross_reference: Reactome:R-HSA-9612973
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
id: GO:0006914
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: autophagy
annotated property: definition
annotated target: The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.
database_cross_reference: GOC:autophagy
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:11099404
database_cross_reference: PMID:29455577
database_cross_reference: PMID:9412464

Autophagy
type: Axiom
annotated source: autophagy
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9612973

response to stress
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
term tracker item: https://github.com/geneontology/go-ontology/issues/26810
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
id: GO:0006950
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: response to stress
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
database_cross_reference: GOC:mah

mitochondrion organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: Reactome:R-HSA-1592230
has_exact_synonym: mitochondria organization
has_exact_synonym: mitochondrial biogenesis
has_exact_synonym: mitochondrial organization
has_exact_synonym: mitochondrion biogenesis
has_exact_synonym: mitochondrion organisation
has_obo_namespace: biological_process
has_related_synonym: mitochondrion morphogenesis
has_related_synonym: mitochondrion organization and biogenesis
id: GO:0007005
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
annotated source: mitochondrion organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:sgd_curators
database_cross_reference: PMID:9786946

Mitochondrial biogenesis
type: Axiom
annotated source: mitochondrion organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1592230

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondria organization
database_cross_reference: GOC:mah

Axiom
annotated source: mitochondrion organization
annotated property: has_exact_synonym
annotated target: mitochondrion organisation
database_cross_reference: GOC:mah

plasma membrane organization
type: Class
subclass of: membrane organization
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
has_exact_synonym: plasma membrane organisation
has_obo_namespace: biological_process
has_related_synonym: plasma membrane organization and biogenesis
id: GO:0007009
in_subset: goslim chembl

Axiom
annotated source: plasma membrane organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: plasma membrane organization
annotated property: has_related_synonym
annotated target: plasma membrane organization and biogenesis
database_cross_reference: GOC:mah

cytoskeleton organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
has_exact_synonym: cytoskeleton organisation
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_related_synonym: cytoskeleton organization and biogenesis
id: GO:0007010
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeleton organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeletal organization and biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cytoskeleton organization
annotated property: has_related_synonym
annotated target: cytoskeleton organization and biogenesis
database_cross_reference: GOC:mah

microtubule-based process
type: Class
subclass of: biological_process
definition: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
has_obo_namespace: biological_process
id: GO:0007017
in_subset: goslim chembl

Axiom
annotated source: microtubule-based process
annotated property: definition
annotated target: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
database_cross_reference: GOC:mah

vacuolar transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
definition: The directed movement of substances into, out of or within a vacuole.
has_obo_namespace: biological_process
id: GO:0007034
in_subset: goslim chembl

Axiom
annotated source: vacuolar transport
annotated property: definition
annotated target: The directed movement of substances into, out of or within a vacuole.
database_cross_reference: GOC:ai

cell cycle
type: Class
subclass of: biological_process
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Reactome:R-HSA-1640170
database_cross_reference: Wikipedia:Cell_cycle
has_exact_synonym: cell-division cycle
has_obo_namespace: biological_process
id: GO:0007049
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cell cycle
annotated property: definition
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle

Cell Cycle
type: Axiom
annotated source: cell cycle
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1640170

chromosome segregation
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: cell cycle
definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_exact_synonym: chromosome division
has_obo_namespace: biological_process
has_related_synonym: chromosome transmission
id: GO:0007059
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: chromosome segregation
annotated property: definition
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: GOC:vw

cell adhesion
type: Class
subclass of: biological_process
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
created by: dos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: cell adhesion
annotated property: definition
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf

signal transduction
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
has_alternative_id: GO:0023014
has_alternative_id: GO:0023015
has_alternative_id: GO:0023016
has_alternative_id: GO:0023033
has_alternative_id: GO:0023045
database_cross_reference: Reactome:R-HSA-212718
database_cross_reference: Wikipedia:Signal_transduction
has_narrow_synonym: signaling cascade
has_narrow_synonym: signalling cascade
has_obo_namespace: biological_process
has_related_synonym: signaling pathway
has_related_synonym: signalling pathway
id: GO:0007165
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.

Axiom
annotated source: signal transduction
annotated property: definition
annotated target: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_signaling_feb11

EGFR interacts with phospholipase C-gamma
type: Axiom
annotated source: signal transduction
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-212718

cell-cell signaling
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
has_exact_synonym: cell-cell signalling
has_obo_namespace: biological_process
id: GO:0007267
in_subset: goslim chembl
in_subset: goslim plant

Axiom
annotated source: cell-cell signaling
annotated property: definition
annotated target: Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

multicellular organism development
type: Class
subclass of: anatomical structure development
definition: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
term tracker item: https://github.com/geneontology/go-ontology/issues/21234
has_obo_namespace: biological_process
id: GO:0007275
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim plant
comment: Note that this term was 'developmental process'.

Axiom
annotated source: multicellular organism development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
database_cross_reference: GOC:dph
database_cross_reference: GOC:ems
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:tb

female pregnancy
type: Class
subclass of: reproductive process
definition: The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
database_cross_reference: Wikipedia:Gestation
has_exact_synonym: gestation
has_obo_namespace: biological_process
has_related_synonym: carrying of young
id: GO:0007565
in_subset: goslim chembl

Axiom
annotated source: female pregnancy
annotated property: definition
annotated target: The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
database_cross_reference: ISBN:0192800825

respiratory gaseous exchange by respiratory system
type: Class
subclass of: biological_process
definition: The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
has_broad_synonym: breathing
has_broad_synonym: respiration
has_obo_namespace: biological_process
id: GO:0007585
in_subset: goslim chembl

Axiom
annotated source: respiratory gaseous exchange by respiratory system
annotated property: definition
annotated target: The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
database_cross_reference: ISBN:0198506732

digestion
type: Class
subclass of: biological_process
definition: The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
database_cross_reference: Reactome:R-HSA-8935690
database_cross_reference: Wikipedia:Digestion
has_obo_namespace: biological_process
id: GO:0007586
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: digestion
annotated property: definition
annotated target: The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
database_cross_reference: GOC:isa_complete
database_cross_reference: ISBN:0198506732

Digestion
type: Axiom
annotated source: digestion
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8935690

chemokine activity
type: Class
subclass of: cytokine activity
subclass of: Restriction
  on property: part of
  some values from: locomotion
subclass of: Restriction
  on property: part of
  some values from: cell motility
definition: The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
has_obo_namespace: molecular_function
id: GO:0008009
in_subset: goslim chembl

Axiom
annotated source: chemokine activity
annotated property: definition
annotated target: The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:rl
database_cross_reference: PMID:12183377
database_cross_reference: Wikipedia:Chemokine

phosphoric diester hydrolase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0004434
has_alternative_id: GO:0016792
database_cross_reference: EC:3.1.4.-
database_cross_reference: Reactome:R-HSA-5693578
has_narrow_synonym: phosphodiesterase
has_obo_namespace: molecular_function
id: GO:0008081
in_subset: goslim chembl

Axiom
annotated source: phosphoric diester hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
database_cross_reference: EC:3.1.4.-

TDP1 and TDP2 process unligatable DSB ends
type: Axiom
annotated source: phosphoric diester hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5693578

growth factor activity
type: Class
subclass of: receptor ligand activity
definition: The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
has_obo_namespace: molecular_function
id: GO:0008083
in_subset: goslim chembl
comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'.

Axiom
annotated source: growth factor activity
annotated property: definition
annotated target: The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
database_cross_reference: ISBN:0815316194

cytoskeletal protein binding
type: Class
subclass of: protein binding
definition: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
has_obo_namespace: molecular_function
id: GO:0008092
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: cytoskeletal protein binding
annotated property: definition
annotated target: Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
database_cross_reference: GOC:mah

transcription factor binding
type: Class
subclass of: protein binding
definition: Binding to a transcription factor, a protein required to initiate or regulate transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/19354
has_exact_synonym: TF binding
has_obo_namespace: molecular_function
has_related_synonym: transcription regulator binding
id: GO:0008134
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.

Axiom
annotated source: transcription factor binding
annotated property: definition
annotated target: Binding to a transcription factor, a protein required to initiate or regulate transcription.
database_cross_reference: ISBN:0198506732

translation factor activity, RNA binding
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: translation
subclass of: Restriction
  on property: has part
  some values from: RNA binding
definition: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
has_broad_synonym: translation factor activity, nucleic acid binding
has_obo_namespace: molecular_function
id: GO:0008135
in_subset: goslim chembl
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: translation factor activity, RNA binding
annotated property: definition
annotated target: Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
database_cross_reference: GOC:ai
database_cross_reference: GOC:vw

Axiom
annotated source: translation factor activity, RNA binding
annotated property: has_broad_synonym
annotated target: translation factor activity, nucleic acid binding
database_cross_reference: GOC:mah

sulfotransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
database_cross_reference: EC:2.8.2.-
database_cross_reference: Reactome:R-HSA-176588
database_cross_reference: Reactome:R-HSA-176604
database_cross_reference: Reactome:R-HSA-176669
database_cross_reference: Reactome:R-HSA-2022061
database_cross_reference: Reactome:R-HSA-9753277
has_exact_synonym: sulphotransferase activity
has_obo_namespace: molecular_function
id: GO:0008146
in_subset: goslim chembl

Axiom
annotated source: sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
database_cross_reference: EC:2.8.2.-

lithocholate + PAPS => lithocholate sulfate + PAP
type: Axiom
annotated source: sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176588

taurolithocholate + PAPS => taurolithocholate sulfate + PAP
type: Axiom
annotated source: sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176604

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
type: Axiom
annotated source: sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176669

Dermatan sulfate can be further sulfated on position 2 of iduronate
type: Axiom
annotated source: sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2022061

SULT dimers sulfate APAP to APAP-SO3
type: Axiom
annotated source: sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9753277

biological_process
type: Class
definition: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
term tracker item: https://github.com/geneontology/go-ontology/issues/24968
created by: jl
creation date: 2012-09-19T15:05:24Z
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_exact_synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

Axiom
annotated source: biological_process
annotated property: definition
annotated target: A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
database_cross_reference: GOC:pdt

metabolic process
type: Class
subclass of: biological_process
definition: A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
created by: jl
creation date: 2012-10-17T15:46:40Z
has_alternative_id: GO:0044236
has_alternative_id: GO:0044710
database_cross_reference: Reactome:R-HSA-1430728
database_cross_reference: Wikipedia:Metabolism
has_exact_synonym: metabolism
has_obo_namespace: biological_process
id: GO:0008152
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote ribbon
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

Axiom
annotated source: metabolic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198547684

Metabolism
type: Axiom
annotated source: metabolic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1430728

methyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a methyl group to an acceptor molecule.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0004480
has_broad_synonym: methylase
database_cross_reference: EC:2.1.1.-
database_cross_reference: Reactome:R-HSA-212269
database_cross_reference: Reactome:R-HSA-379387
database_cross_reference: Reactome:R-HSA-379464
database_cross_reference: Reactome:R-HSA-5333608
database_cross_reference: Reactome:R-HSA-6800149
database_cross_reference: Reactome:R-HSA-71286
database_cross_reference: Reactome:R-HSA-9710490
has_obo_namespace: molecular_function
id: GO:0008168
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: methyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a methyl group to an acceptor molecule.
database_cross_reference: ISBN:0198506732

DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-212269

COMT transfers Met to DA to form 3MT
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379387

COMT transfers Met to DOPAC to form HVA
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-379464

GSSebGalNac is reduced and methylated to MeSebGalNac
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333608

N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6800149

guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-71286

The GSDME gene promoter is hypermethylated
type: Axiom
annotated source: methyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9710490

bioluminescence
type: Class
subclass of: metabolic process
definition: The production of light by certain enzyme-catalyzed reactions in cells.
database_cross_reference: Wikipedia:Bioluminescence
has_obo_namespace: biological_process
id: GO:0008218
in_subset: goslim chembl
in_subset: goslim metagenomics

Axiom
annotated source: bioluminescence
annotated property: definition
annotated target: The production of light by certain enzyme-catalyzed reactions in cells.
database_cross_reference: ISBN:0198506732

peptidase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0070010
has_alternative_id: GO:0070011
database_cross_reference: EC:3.4.-.-
database_cross_reference: Reactome:R-HSA-205112
database_cross_reference: Reactome:R-HSA-3000243
database_cross_reference: Reactome:R-HSA-3000263
database_cross_reference: Reactome:R-HSA-3065958
database_cross_reference: Reactome:R-HSA-3065959
database_cross_reference: Reactome:R-HSA-3139027
database_cross_reference: Reactome:R-HSA-376149
database_cross_reference: Reactome:R-HSA-4167501
database_cross_reference: Reactome:R-HSA-448678
database_cross_reference: Reactome:R-HSA-5655483
database_cross_reference: Reactome:R-HSA-5684864
database_cross_reference: Reactome:R-HSA-5685902
database_cross_reference: Reactome:R-HSA-6803060
database_cross_reference: Reactome:R-HSA-9935547
has_exact_synonym: hydrolase, acting on peptide bonds
has_exact_synonym: peptide hydrolase activity
has_exact_synonym: protease activity
has_narrow_synonym: peptidase activity, acting on D-amino acid peptides
has_narrow_synonym: peptidase activity, acting on L-amino acid peptides
has_narrow_synonym: proteinase activity
has_obo_namespace: molecular_function
id: GO:0008233
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: peptidase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
database_cross_reference: EC:3.4.-.-
database_cross_reference: GOC:jl

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205112

Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000243

TCN2:RCbl is degraded to release RCbl
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3000263

An unknown protease degrades ACACA
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065958

An unknown protease degrades hCBXs
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3065959

Maturation of HIV Virion
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3139027

Proteolytic processing of SLIT
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-376149

An unknown protease degrades ACACB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4167501

CTSG cleaves CASP1(1-404)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-448678

USP1 autocleavage
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5655483

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5684864

NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5685902

DCD(63-110) is processed to DCD(63-109)
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6803060

Lysosomal degradation of ubiqutinated CDH1
type: Axiom
annotated source: peptidase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9935547

cell population proliferation
type: Class
subclass of: biological_process
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
has_obo_namespace: biological_process
has_related_synonym: cell proliferation
id: GO:0008283
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.

Axiom
annotated source: cell population proliferation
annotated property: definition
annotated target: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mb

lipid binding
type: Class
subclass of: molecular_function
definition: Binding to a lipid.
has_obo_namespace: molecular_function
id: GO:0008289
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: lipid binding
annotated property: definition
annotated target: Binding to a lipid.
database_cross_reference: GOC:ai

palmitoyl-(protein) hydrolase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
subclass of: Restriction
  on property: part of
  some values from: metabolic process
definition: Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: palmitoyl-[protein] hydrolase
database_cross_reference: EC:3.1.2.22
database_cross_reference: MetaCyc:3.1.2.22-RXN
database_cross_reference: RHEA:19233
database_cross_reference: Reactome:R-HSA-203613
database_cross_reference: Reactome:R-HSA-5690517
database_cross_reference: Reactome:R-HSA-8933328
database_cross_reference: Reactome:R-HSA-9647994
has_exact_synonym: palmitoyl-protein hydrolase activity
has_exact_synonym: palmitoyl-protein thioesterase activity
has_exact_synonym: palmitoyl-protein thiolesterase activity
has_obo_namespace: molecular_function
id: GO:0008474
in_subset: goslim chembl

Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: definition
annotated target: Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
database_cross_reference: EC:3.1.2.22

Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: has_broad_synonym
annotated target: palmitoyl-[protein] hydrolase
database_cross_reference: EC:3.1.2.22

Depalmitoylation of eNOS
type: Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-203613

PPT1 hydrolyses palmitoylated proteins
type: Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690517

LYPLA2 hydrolyses PALM-C3,4-GAP43
type: Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8933328

RAS proteins are depalmitoylated
type: Axiom
annotated source: palmitoyl-(protein) hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9647994

protein-tyrosine sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.8.2.20
database_cross_reference: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:16801
database_cross_reference: Reactome:R-HSA-8954262
database_cross_reference: Reactome:R-HSA-9668023
database_cross_reference: Reactome:R-HSA-9668148
has_exact_synonym: protein-tyrosine sulphotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity
has_related_synonym: tyrosylprotein sulfotransferase activity
id: GO:0008476
in_subset: goslim chembl

Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
database_cross_reference: EC:2.8.2.20

TPST1,2 transfer SO4(2-) from PAPS to PODXL2
type: Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8954262

TPST1,2 transfer SO4(2-) from PAPS to FVIII
type: Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9668023

F8 variant is not sulfonated at Y1699
type: Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9668148

Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity
database_cross_reference: EC:2.8.2.20

Axiom
annotated source: protein-tyrosine sulfotransferase activity
annotated property: has_related_synonym
annotated target: tyrosylprotein sulfotransferase activity
database_cross_reference: EC:2.8.2.20

phospho-N-acetylmuramoyl-pentapeptide-transferase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP.
term tracker item: https://github.com/geneontology/go-ontology/issues/28070
database_cross_reference: MetaCyc:RXN-8975
database_cross_reference: RHEA:21920
has_narrow_synonym: MraY transferase activity
has_obo_namespace: molecular_function
has_related_synonym: UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity
has_related_synonym: UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
has_related_synonym: UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
has_related_synonym: UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity
has_related_synonym: UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity
has_related_synonym: UDP-MurNAc-pentapeptide phosphotransferase activity
has_related_synonym: phospho-MurNAc-pentapeptide transferase activity
has_related_synonym: phospho-N-acetylmuramoyl pentapeptide translocase activity
has_related_synonym: phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity
has_related_synonym: phosphoacetylmuramoylpentapeptide translocase activity
has_related_synonym: phosphoacetylmuramoylpentapeptidetransferase activity
id: GO:0008963
in_subset: goslim chembl
comment: Note that EC classifies all three 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under EC:2.7.8.13.
broad match: http://purl.uniprot.org/enzyme/2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: definition
annotated target: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP.
database_cross_reference: RHEA:21920

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_narrow_synonym
annotated target: MraY transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: UDP-MurNAc-pentapeptide phosphotransferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: phospho-MurNAc-pentapeptide transferase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: phospho-N-acetylmuramoyl pentapeptide translocase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: phosphoacetylmuramoylpentapeptide translocase activity
database_cross_reference: EC:2.7.8.13

Axiom
annotated source: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
annotated property: has_related_synonym
annotated target: phosphoacetylmuramoylpentapeptidetransferase activity
database_cross_reference: EC:2.7.8.13

glycerophospholipid phospholipase A1 activity
type: Class
subclass of: glycerophospholipase activity
definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H+. Note that the substrate has a diacyl group attached to the glycerol group.
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
has_broad_synonym: diacylphospholipase A1 activity
database_cross_reference: EC:3.1.1.32
database_cross_reference: MetaCyc:PHOSPHOLIPASE-A1-RXN
database_cross_reference: RHEA:67424
database_cross_reference: Reactome:R-HSA-1482827
database_cross_reference: Reactome:R-HSA-1482828
database_cross_reference: Reactome:R-HSA-1482847
database_cross_reference: Reactome:R-HSA-1482862
database_cross_reference: Reactome:R-HSA-1482892
database_cross_reference: Reactome:R-HSA-1482920
database_cross_reference: Reactome:R-HSA-1482932
database_cross_reference: Reactome:R-HSA-5694485
database_cross_reference: Reactome:R-HSA-8869425
has_narrow_synonym: phosphatidylcholine 1-acylhydrolase activity
has_narrow_synonym: phosphatidylserine 1-acylhydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: phospholipase A1 activity
id: GO:0008970
in_subset: goslim chembl

Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: definition
annotated target: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H+. Note that the substrate has a diacyl group attached to the glycerol group.
database_cross_reference: RHEA:67424

PC is hydrolyzed to 2-acyl LPC by PLA2G4C
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482827

PE is hydrolyzed to 2-acyl LPE by PLA2[4]
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482828

PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482847

PC is hydrolysed to 2-acyl LPC by PLA2[7]
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482862

PE is hydrolyzed to 2-acyl LPE by PLA2G4C
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482892

PG is hydrolyzed to 2-acyl LPG by PLA2[14]
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482920

PI is hydrolyzed to 2-acyl LPI by PLA2[13]
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482932

ABHD3 hydrolyses LPC(14:0) to 1AGPC
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694485

PLA1A hydrolyses PS to 2-acyl LPS
type: Axiom
annotated source: glycerophospholipid phospholipase A1 activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8869425

catabolic process
type: Class
subclass of: metabolic process
definition: A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
term tracker item: https://github.com/geneontology/go-ontology/issues/28921
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
term tracker item: https://github.com/geneontology/go-ontology/issues/29627
created by: jl
creation date: 2012-10-17T15:52:35Z
has_alternative_id: GO:0044243
has_alternative_id: GO:0044712
database_cross_reference: Wikipedia:Catabolism
has_exact_synonym: breakdown of chemical
has_exact_synonym: breakdown of molecule
has_exact_synonym: breakdown of substance
has_exact_synonym: catabolism
has_exact_synonym: cellular breakdown
has_exact_synonym: cellular catabolism
has_exact_synonym: cellular degradation
has_exact_synonym: degradation
has_obo_namespace: biological_process
id: GO:0009056
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: catabolic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: ISBN:0198547684

biosynthetic process
type: Class
subclass of: metabolic process
definition: A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
term tracker item: https://github.com/geneontology/go-ontology/issues/28932
created by: jl
creation date: 2012-10-17T15:52:18Z
has_alternative_id: GO:0044274
has_alternative_id: GO:0044711
has_broad_synonym: formation
database_cross_reference: Wikipedia:Anabolism
has_exact_synonym: anabolism
has_exact_synonym: biosynthesis
has_exact_synonym: synthesis
has_narrow_synonym: multicellular organismal biosynthetic process
has_obo_namespace: biological_process
has_related_synonym: single-organism biosynthetic process
id: GO:0009058
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: biosynthetic process
annotated property: definition
annotated target: A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198547684

amine metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
created by: jl
creation date: 2009-07-15T11:55:44Z
has_alternative_id: GO:0044106
has_exact_synonym: amine metabolism
has_exact_synonym: cellular amine metabolic process
has_obo_namespace: biological_process
id: GO:0009308
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: amine metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

plastid
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
database_cross_reference: Wikipedia:Plastid
has_obo_namespace: cellular_component
id: GO:0009536
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: plastid
annotated property: definition
annotated target: Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198547684

thylakoid
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: intracellular anatomical structure
definition: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
term tracker item: https://github.com/geneontology/go-ontology/issues/13958
database_cross_reference: Wikipedia:Thylakoid
has_obo_namespace: cellular_component
has_related_synonym: photosynthetic membrane
id: GO:0009579
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.

Axiom
annotated source: thylakoid
annotated property: definition
annotated target: A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
database_cross_reference: GOC:ds
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

response to toxic substance
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
has_narrow_synonym: detoxification response
has_obo_namespace: biological_process
has_related_synonym: toxin resistance
has_related_synonym: toxin susceptibility/resistance
id: GO:0009636
in_subset: goslim chembl

Axiom
annotated source: response to toxic substance
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
database_cross_reference: GOC:lr

cytokinin metabolic process
type: Class
subclass of: amine metabolic process
definition: The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.
has_exact_synonym: cytokinin metabolism
has_obo_namespace: biological_process
id: GO:0009690
in_subset: goslim chembl

Axiom
annotated source: cytokinin metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.
database_cross_reference: ISBN:0387969845

embryo development
type: Class
subclass of: multicellular organism development
definition: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
has_alternative_id: GO:0009795
has_broad_synonym: embryogenesis and morphogenesis
database_cross_reference: Reactome:R-HSA-5619507
database_cross_reference: Wikipedia:Embryogenesis
has_exact_synonym: embryogenesis
has_exact_synonym: embryonal development
has_obo_namespace: biological_process
id: GO:0009790
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim plant

Axiom
annotated source: embryo development
annotated property: definition
annotated target: The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_sensu

Activation of HOX genes during differentiation
type: Axiom
annotated source: embryo development
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5619507

alkaloid metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).
has_exact_synonym: alkaloid metabolism
has_obo_namespace: biological_process
id: GO:0009820
in_subset: goslim chembl

Axiom
annotated source: alkaloid metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).
database_cross_reference: GOC:lr
database_cross_reference: ISBN:0122146743

negative regulation of endopeptidase activity
type: Class
subclass of: regulation of catalytic activity
subclass of: Restriction
  on property: regulates
  some values from: proteolysis
subclass of: Restriction
  on property: regulates
  some values from: peptidase activity
subclass of: Restriction
  on property: negatively regulates
  some values from: proteolysis
subclass of: Restriction
  on property: negatively regulates
  some values from: peptidase activity
definition: Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
created by: tb
creation date: 2009-04-27T11:47:01Z
has_obo_namespace: biological_process
id: GO:0010951
in_subset: gocheck obsoletion candidate
in_subset: goslim chembl

Axiom
annotated source: negative regulation of endopeptidase activity
annotated property: definition
annotated target: Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

programmed cell death
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: has part
  some values from: signal transduction
definition: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/24835
has_alternative_id: GO:0016244
has_broad_synonym: regulated cell death
database_cross_reference: Reactome:R-HSA-5357801
database_cross_reference: Wikipedia:Programmed_cell_death
has_narrow_synonym: caspase-independent cell death
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: PCD
has_related_synonym: RCD
has_related_synonym: caspase-independent apoptosis
id: GO:0012501
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Axiom
annotated source: programmed cell death
annotated property: definition
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis

Programmed Cell Death
type: Axiom
annotated source: programmed cell death
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5357801

protein transport
type: Class
subclass of: transport
definition: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_alternative_id: GO:0015831
has_narrow_synonym: enzyme transport
has_obo_namespace: biological_process
id: GO:0015031
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: protein transport
annotated property: definition
annotated target: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai

carbon utilization
type: Class
subclass of: biological_process
definition: A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
has_alternative_id: GO:0015978
database_cross_reference: Wikipedia:Heterotroph
has_exact_synonym: carbon utilization by utilization of organic compounds
has_exact_synonym: heterotrophy
has_obo_namespace: biological_process
id: GO:0015976
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: carbon utilization
annotated property: definition
annotated target: A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mlg

Axiom
annotated source: carbon utilization
annotated property: has_exact_synonym
annotated target: carbon utilization by utilization of organic compounds
database_cross_reference: GOC:mah

photosynthesis
type: Class
subclass of: metabolic process
definition: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
database_cross_reference: Wikipedia:Photosynthesis
has_obo_namespace: biological_process
id: GO:0015979
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: photosynthesis
annotated property: definition
annotated target: The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds.
database_cross_reference: ISBN:0198547684

membrane
type: Class
subclass of: cellular_component
definition: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
creation date: 2014-03-06T11:37:54Z
has_alternative_id: GO:0016021
has_alternative_id: GO:0098589
has_alternative_id: GO:0098805
database_cross_reference: Wikipedia:Biological_membrane
database_cross_reference: Wikipedia:Transmembrane_protein
has_narrow_synonym: integral component of membrane
has_narrow_synonym: integral to membrane
has_narrow_synonym: membrane region
has_narrow_synonym: region of membrane
has_narrow_synonym: whole membrane
has_obo_namespace: cellular_component
has_related_synonym: transmembrane
id: GO:0016020
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated source: membrane
annotated property: definition
annotated target: A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194

Axiom
annotated source: membrane
annotated property: has_related_synonym
annotated target: transmembrane
database_cross_reference: GOC:mah

vesicle-mediated transport
type: Class
subclass of: transport
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
term tracker item: https://github.com/geneontology/go-ontology/issues/25421
has_alternative_id: GO:0006899
has_exact_synonym: vesicle transport
has_exact_synonym: vesicular transport
has_narrow_synonym: nonselective vesicle transport
has_obo_namespace: biological_process
has_related_synonym: protein sorting along secretory pathway
has_related_synonym: vesicle trafficking
id: GO:0016192
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe

Axiom
annotated source: vesicle-mediated transport
annotated property: definition
annotated target: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: ISBN:08789310662000

Axiom
annotated source: vesicle-mediated transport
annotated property: has_exact_synonym
annotated target: vesicular transport
database_cross_reference: GOC:mah

lipase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the hydrolysis of a lipid.
term tracker item: https://github.com/geneontology/go-ontology/issues/21843
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
database_cross_reference: Reactome:R-HSA-163402
database_cross_reference: Reactome:R-HSA-163432
has_obo_namespace: molecular_function
id: GO:0016298
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: lipase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a lipid.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732

diacylglycerol + H2O -> 2-acylglycerol + fatty acid
type: Axiom
annotated source: lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163402

cholesterol ester + H2O -> cholesterol + fatty acid
type: Axiom
annotated source: lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163432

kinase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_exact_synonym: phosphokinase activity
has_obo_namespace: molecular_function
id: GO:0016301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.

Axiom
annotated source: kinase activity
annotated property: definition
annotated target: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
database_cross_reference: ISBN:0198506732

FN3KRP phosphorylates PsiAm, RibAm
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788855

FN3K phosphorylates ketosamines
type: Axiom
annotated source: kinase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788867

phosphorylation
type: Class
subclass of: metabolic process
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
database_cross_reference: Wikipedia:Phosphorylation
has_obo_namespace: biological_process
id: GO:0016310
in_subset: gocheck obsoletion candidate
in_subset: goslim chembl
in_subset: goslim metagenomics

Axiom
annotated source: phosphorylation
annotated property: definition
annotated target: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: ISBN:0198506732

protein processing
type: Class
subclass of: proteolysis
subclass of: protein maturation
definition: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
has_alternative_id: GO:0051605
database_cross_reference: Reactome:R-HSA-9033500
has_exact_synonym: protein maturation by peptide bond cleavage
has_exact_synonym: protein maturation by peptide bond hydrolysis
has_obo_namespace: biological_process
has_related_synonym: peptidolysis during protein maturation
has_related_synonym: protein maturation by proteolysis
id: GO:0016485
in_subset: goslim chembl

Axiom
annotated source: protein processing
annotated property: definition
annotated target: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:curators
database_cross_reference: GOC:jl
database_cross_reference: GOC:jsg

TYSND1 cleaves peroxisomal proteins
type: Axiom
annotated source: protein processing
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9033500

Axiom
annotated source: protein processing
annotated property: has_exact_synonym
annotated target: protein maturation by peptide bond cleavage
database_cross_reference: GOC:bf

Axiom
annotated source: protein processing
annotated property: has_exact_synonym
annotated target: protein maturation by peptide bond hydrolysis
database_cross_reference: GOC:mah

Axiom
annotated source: protein processing
annotated property: has_related_synonym
annotated target: peptidolysis during protein maturation
database_cross_reference: GOC:mah

Axiom
annotated source: protein processing
annotated property: has_related_synonym
annotated target: protein maturation by proteolysis
database_cross_reference: GOC:mah

oxidoreductase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:1.-.-.-
database_cross_reference: Reactome:R-HSA-1614362
database_cross_reference: Reactome:R-HSA-2161612
database_cross_reference: Reactome:R-HSA-265296
database_cross_reference: Reactome:R-HSA-266051
database_cross_reference: Reactome:R-HSA-390425
database_cross_reference: Reactome:R-HSA-390438
database_cross_reference: Reactome:R-HSA-8936442
database_cross_reference: Reactome:R-HSA-9020249
database_cross_reference: Reactome:R-HSA-9020260
database_cross_reference: Reactome:R-HSA-9024624
database_cross_reference: Reactome:R-HSA-9024630
database_cross_reference: Reactome:R-HSA-9025007
database_cross_reference: Reactome:R-HSA-9026001
database_cross_reference: Reactome:R-HSA-9026917
database_cross_reference: Reactome:R-HSA-9027033
database_cross_reference: Reactome:R-HSA-9693722
database_cross_reference: Reactome:R-HSA-9759549
has_exact_synonym: redox activity
has_narrow_synonym: oxidoreductase activity, acting on other substrates
has_obo_namespace: molecular_function
id: GO:0016491
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: oxidoreductase activity
annotated property: definition
annotated target: Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
database_cross_reference: EC:1.-.-.-

SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1614362

PGH2 is reduced to PGF2a by FAM213B
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161612

Arachidonate is oxidised to 5S-HpETE by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-265296

5S-HpETE is dehydrated to LTA4 by ALOX5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-266051

FAR1 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390425

FAR2 reduces PalmCoA to HXOL
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-390438

MARC1,MARC2 reduce N-hydroxylated compounds
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8936442

Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020249

Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9020260

Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024624

Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9024630

Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9025007

Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026001

Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9026917

Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9027033

Unknown sepiapterin synthase transforms PTHP to sepiapterin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9693722

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
type: Axiom
annotated source: oxidoreductase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9759549

protein autoprocessing
type: Class
subclass of: protein processing
definition: Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
has_obo_namespace: biological_process
id: GO:0016540
in_subset: goslim chembl

Axiom
annotated source: protein autoprocessing
annotated property: definition
annotated target: Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.
database_cross_reference: GOC:ai
database_cross_reference: PMID:9335337

transferase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.-.-.-
database_cross_reference: Reactome:R-HSA-1483089
database_cross_reference: Reactome:R-HSA-1483186
database_cross_reference: Reactome:R-HSA-5333607
database_cross_reference: Reactome:R-HSA-5668414
database_cross_reference: Reactome:R-HSA-8868783
has_obo_namespace: molecular_function
id: GO:0016740
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: transferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2.-.-.-

PE is converted to PS by PTDSS2
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483089

PC is converted to PS by PTDSS1
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1483186

GSSeH combines with bGalNAc derivative to form GSSebGalNac
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333607

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5668414

TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248
type: Axiom
annotated source: transferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8868783

acyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/20486
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0008415
database_cross_reference: EC:2.3.-.-
database_cross_reference: Reactome:R-HSA-159431
database_cross_reference: Reactome:R-HSA-192312
database_cross_reference: Reactome:R-HSA-193491
database_cross_reference: Reactome:R-HSA-8858298
has_exact_synonym: transferase activity, transferring acyl groups
has_obo_namespace: molecular_function
id: GO:0016746
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: acyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.3.-.-

Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-159431

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192312

Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-193491

HRASLS transfer acyl group from PC to PE to form NAPE
type: Axiom
annotated source: acyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8858298

glycosyltransferase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0016932
database_cross_reference: EC:2.4.-.-
database_cross_reference: Reactome:R-HSA-5173005
database_cross_reference: Reactome:R-HSA-6785565
has_exact_synonym: transferase activity, transferring glycosyl groups
has_exact_synonym: transglycosidase activity
has_exact_synonym: transglycosylase activity
has_narrow_synonym: transferase activity, transferring other glycosyl groups
has_obo_namespace: molecular_function
id: GO:0016757
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: glycosyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

B3GALTL transfers glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5173005

Defective B3GALTL does not transfer glucose to O-fucosyl-proteins
type: Axiom
annotated source: glycosyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6785565

transferase activity, transferring alkyl or aryl (other than methyl) groups
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0016766
database_cross_reference: EC:2.5.1.-
database_cross_reference: Reactome:R-HSA-3095889
database_cross_reference: Reactome:R-HSA-4419978
database_cross_reference: Reactome:R-HSA-4755545
database_cross_reference: Reactome:R-HSA-6782893
has_exact_synonym: transferase activity, transferring alkyl or aryl groups, other than methyl groups
has_obo_namespace: molecular_function
id: GO:0016765
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: definition
annotated target: Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.5.1.-

MMACHC dealkylates RCbl
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3095889

DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4419978

Defective DHDDS does not elongate E,E-FPP
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4755545

TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: transferase activity, transferring alkyl or aryl (other than methyl) groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782893

transferase activity, transferring phosphorus-containing groups
type: Class
subclass of: transferase activity
definition: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.-.-
database_cross_reference: Reactome:R-HSA-9932322
has_obo_namespace: molecular_function
id: GO:0016772
in_subset: goslim chembl
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.

Axiom
annotated source: transferase activity, transferring phosphorus-containing groups
annotated property: definition
annotated target: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7.-.-

BcsG transfers pEtN from PE onto cellulose
type: Axiom
annotated source: transferase activity, transferring phosphorus-containing groups
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9932322

nucleotidyltransferase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.7.7.-
database_cross_reference: Reactome:R-HSA-6782434
has_obo_namespace: molecular_function
id: GO:0016779
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: nucleotidyltransferase activity
annotated property: definition
annotated target: Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7.7.-

THG1L transfers GMP to 5' end of tRNA(His)
type: Axiom
annotated source: nucleotidyltransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782434

hydrolase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.-.-.-
database_cross_reference: Reactome:R-HSA-1236938
database_cross_reference: Reactome:R-HSA-2029475
database_cross_reference: Reactome:R-HSA-5694583
database_cross_reference: Reactome:R-HSA-5695964
database_cross_reference: Reactome:R-HSA-6786190
database_cross_reference: Reactome:R-HSA-6788295
database_cross_reference: Reactome:R-HSA-8938314
database_cross_reference: Reactome:R-HSA-8952137
database_cross_reference: Reactome:R-HSA-9942295
has_obo_namespace: molecular_function
id: GO:0016787
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
database_cross_reference: ISBN:0198506732

Partial proteolysis of antigen in phagolysosomes
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236938

Production of AA by iPLA2 upon FCGR activation
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2029475

ABHD4 hydrolyses NAPE
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694583

ABHD14B hydrolyses PNPB
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5695964

CMBL hydrolyses OM to OLMS
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6786190

HDHD1:Mg2+ dephosphorylates PURIDP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6788295

ENPPs hydrolyse CoA-SH to PPANT, PAP
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8938314

Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8952137

QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate
type: Axiom
annotated source: hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9942295

hydrolase activity, acting on ester bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any ester bond.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.-.-
database_cross_reference: Reactome:R-HSA-162729
database_cross_reference: Reactome:R-HSA-9023617
database_cross_reference: Reactome:R-HSA-9023619
database_cross_reference: Reactome:R-HSA-9749609
has_exact_synonym: esterase activity
has_obo_namespace: molecular_function
id: GO:0016788
in_subset: goslim chembl

Axiom
annotated source: hydrolase activity, acting on ester bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any ester bond.
database_cross_reference: GOC:jl

uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
type: Axiom
annotated source: hydrolase activity, acting on ester bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-162729

Butyrylcholinesterase hydrolyzes acyl Ghrelin
type: Axiom
annotated source: hydrolase activity, acting on ester bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023617

Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin
type: Axiom
annotated source: hydrolase activity, acting on ester bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9023619

BCHE hydrolyzes ASA-
type: Axiom
annotated source: hydrolase activity, acting on ester bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9749609

phosphatase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/25755
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0003869
has_alternative_id: GO:0016302
database_cross_reference: EC:3.1.3.-
database_cross_reference: Reactome:R-HSA-4419986
database_cross_reference: Reactome:R-HSA-9636457
database_cross_reference: Reactome:R-HSA-9837419
database_cross_reference: Reactome:R-HSA-9940993
has_exact_synonym: phosphoric monoester hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: phosphatase
id: GO:0016791
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
annotated source: phosphatase activity
annotated property: definition
annotated target: Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pg

Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-4419986

SapM dephosphorylates PI3P
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9636457

PANK4 hydrolyzes PPANT to pantetheine
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9837419

PXYLP1 dephosphorylates Xyl moiety
type: Axiom
annotated source: phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9940993

hydrolase activity, acting on glycosyl bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any glycosyl bond.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.2.-.-
database_cross_reference: Reactome:R-HSA-1793176
database_cross_reference: Reactome:R-HSA-2065233
database_cross_reference: Reactome:R-HSA-5333609
has_exact_synonym: glycosidase activity
has_narrow_synonym: N-glycosylase
has_narrow_synonym: glycosylase
has_obo_namespace: molecular_function
id: GO:0016798
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any glycosyl bond.
database_cross_reference: GOC:jl

DS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1793176

CS is cleaved from its proteoglycan
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2065233

MeSebGalNac is hydrolysed to MeSeH and bGalNac
type: Axiom
annotated source: hydrolase activity, acting on glycosyl bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5333609

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
type: Class
subclass of: hydrolase activity
definition: Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.5.-.-
database_cross_reference: Reactome:R-HSA-6803753
has_narrow_synonym: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
has_obo_namespace: molecular_function
id: GO:0016810
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
annotated property: definition
annotated target: Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
database_cross_reference: EC:3.5.-.-

NAAA hydrolyses NAEs to FAs and ethanolamine
type: Axiom
annotated source: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6803753

lyase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:4.-.-.-
database_cross_reference: Reactome:R-HSA-5696408
database_cross_reference: Reactome:R-HSA-6782895
has_obo_namespace: molecular_function
id: GO:0016829
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: lyase activity
annotated property: definition
annotated target: Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
database_cross_reference: EC:4.-.-.-

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5696408

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)
type: Axiom
annotated source: lyase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6782895

isomerase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:5.-.-.-
database_cross_reference: Reactome:R-HSA-2161666
database_cross_reference: Reactome:R-HSA-2161735
database_cross_reference: Reactome:R-HSA-6787623
has_narrow_synonym: other isomerase activity
has_obo_namespace: molecular_function
id: GO:0016853
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: isomerase activity
annotated property: definition
annotated target: Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
database_cross_reference: ISBN:0198506732

PGA2 is isomerised to PGC2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161666

PGC2 is isomerised to PGB2
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161735

GFUS dimer epimerises GDP-DHDMan to GDP-KDGal
type: Axiom
annotated source: isomerase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6787623

ligase activity
type: Class
subclass of: catalytic activity
definition: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/19380
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:6.-.-.-
has_exact_synonym: synthetase activity
has_obo_namespace: molecular_function
id: GO:0016874
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: ligase activity
annotated property: definition
annotated target: Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
database_cross_reference: EC:6.-.-.-

Axiom
annotated source: ligase activity
annotated property: has_exact_synonym
annotated target: synthetase activity
database_cross_reference: GOC:jh2

galactoside binding
type: Class
subclass of: molecular_function
definition: Binding to a glycoside in which the sugar group is galactose.
has_obo_namespace: molecular_function
id: GO:0016936
in_subset: goslim chembl

Axiom
annotated source: galactoside binding
annotated property: definition
annotated target: Binding to a glycoside in which the sugar group is galactose.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732

ribonucleoside triphosphate phosphatase activity
type: Class
subclass of: hydrolase activity
definition: Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
term tracker item: https://github.com/geneontology/go-ontology/issues/21232
term tracker item: https://github.com/geneontology/go-ontology/issues/23401
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: apyrase activity
has_broad_synonym: nucleoside 5-triphosphatase activity
has_broad_synonym: nucleoside triphosphatase activity
has_broad_synonym: nucleoside triphosphate hydrolase activity
has_broad_synonym: nucleoside triphosphate phosphatase activity
has_broad_synonym: nucleoside-triphosphatase activity
database_cross_reference: EC:3.6.1.15
database_cross_reference: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN
database_cross_reference: RHEA:23680
database_cross_reference: Reactome:R-HSA-8850846
database_cross_reference: Reactome:R-HSA-8851089
database_cross_reference: Reactome:R-HSA-8851110
database_cross_reference: Reactome:R-HSA-8851234
database_cross_reference: Reactome:R-HSA-8851494
database_cross_reference: Reactome:R-HSA-8851538
has_exact_synonym: NTPase activity
has_obo_namespace: molecular_function
has_related_synonym: nucleoside triphosphate phosphohydrolase activity
has_related_synonym: nucleoside-5-triphosphate phosphohydrolase activity
id: GO:0017111
in_subset: goslim chembl
in_subset: goslim metagenomics

Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: definition
annotated target: Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
database_cross_reference: RHEA:23680

Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: has_broad_synonym
annotated target: nucleoside 5-triphosphatase activity
database_cross_reference: EC:3.6.1.15

NTPDase1 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8850846

NTPDase2 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851089

NTPDase3 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851110

NTPDase4 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851234

NTPDase7 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851494

NTPDase8 hydrolyzes nucleoside triphosphates
type: Axiom
annotated source: ribonucleoside triphosphate phosphatase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8851538

Wnt-protein binding
type: Class
subclass of: protein binding
definition: Binding to a Wnt-protein, a secreted growth factor involved in signaling.
has_obo_namespace: molecular_function
id: GO:0017147
in_subset: goslim chembl

Axiom
annotated source: Wnt-protein binding
annotated property: definition
annotated target: Binding to a Wnt-protein, a secreted growth factor involved in signaling.
database_cross_reference: GOC:jl

S-formylglutathione hydrolase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.2.12
database_cross_reference: KEGG_REACTION:R00527
database_cross_reference: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN
database_cross_reference: RHEA:14961
database_cross_reference: Reactome:R-HSA-5693724
database_cross_reference: UM-BBD_reactionID:r0241
has_obo_namespace: molecular_function
id: GO:0018738
in_subset: goslim chembl

Axiom
annotated source: S-formylglutathione hydrolase activity
annotated property: definition
annotated target: Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+.
database_cross_reference: EC:3.1.2.12
database_cross_reference: RHEA:14961

ESD dimer hydrolyses S-FGSH to GSH
type: Axiom
annotated source: S-formylglutathione hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5693724

viral nucleocapsid
type: Class
subclass of: virion component
subclass of: Restriction
  on property: part of
  some values from: viral capsid
definition: The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.
has_alternative_id: GO:0019014
has_broad_synonym: core
has_exact_synonym: nucleocapsid
has_obo_namespace: cellular_component
id: GO:0019013
in_subset: goslim chembl

Axiom
annotated source: viral nucleocapsid
annotated property: definition
annotated target: The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.
database_cross_reference: ISBN:0781702534

viral capsid
type: Class
subclass of: virion component
definition: The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.
has_alternative_id: GO:0046728
database_cross_reference: Wikipedia:Capsid
has_obo_namespace: cellular_component
id: GO:0019028
in_subset: goslim chembl
in_subset: goslim virus

Axiom
annotated source: viral capsid
annotated property: definition
annotated target: The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.
database_cross_reference: GOC:mtg_sensu
database_cross_reference: ISBN:0198506732

viral envelope
type: Class
subclass of: virion component
definition: The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.
database_cross_reference: Wikipedia:Viral_envelope
has_exact_synonym: viral outside membrane
has_obo_namespace: cellular_component
has_related_synonym: viral glycoprotein
id: GO:0019031
in_subset: goslim chembl

Axiom
annotated source: viral envelope
annotated property: definition
annotated target: The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.
database_cross_reference: GOC:bf
database_cross_reference: GOC:bm
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0781718325
database_cross_reference: Wikipedia:Viral_envelope

secondary metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
database_cross_reference: Wikipedia:Secondary_metabolism
has_exact_synonym: secondary metabolism
has_exact_synonym: secondary metabolite metabolic process
has_exact_synonym: secondary metabolite metabolism
has_obo_namespace: biological_process
id: GO:0019748
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim pombe

Axiom
annotated source: secondary metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
database_cross_reference: GOC:go_curators

cytolysis
type: Class
subclass of: biological_process
definition: The rupture of cell membranes and the loss of cytoplasm.
has_broad_synonym: lysis
database_cross_reference: Wikipedia:Cytolysis
has_obo_namespace: biological_process
has_related_synonym: autolysin activity
has_related_synonym: bacteriocin activity
has_related_synonym: bacteriolytic toxin activity
has_related_synonym: holin
has_related_synonym: lysin activity
has_related_synonym: necrosis
id: GO:0019835
in_subset: goslim chembl

Axiom
annotated source: cytolysis
annotated property: definition
annotated target: The rupture of cell membranes and the loss of cytoplasm.
database_cross_reference: UniProtKB-KW:KW-0204

growth factor binding
type: Class
subclass of: protein binding
definition: Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
has_obo_namespace: molecular_function
has_related_synonym: neurotrophin TRK receptor activity
id: GO:0019838
in_subset: goslim chembl

Axiom
annotated source: growth factor binding
annotated property: definition
annotated target: Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
database_cross_reference: GOC:curators

rRNA binding
type: Class
subclass of: RNA binding
definition: Binding to a ribosomal RNA.
has_alternative_id: GO:0000944
has_narrow_synonym: base pairing with rRNA
has_obo_namespace: molecular_function
id: GO:0019843
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: rRNA binding
annotated property: definition
annotated target: Binding to a ribosomal RNA.
database_cross_reference: GOC:jl

IgG binding
type: Class
subclass of: protein-containing complex binding
definition: Binding to an immunoglobulin of an IgG isotype.
has_obo_namespace: molecular_function
id: GO:0019864
in_subset: goslim chembl

Axiom
annotated source: IgG binding
annotated property: definition
annotated target: Binding to an immunoglobulin of an IgG isotype.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149

enzyme binding
type: Class
subclass of: protein binding
definition: Binding to an enzyme, a protein with catalytic activity.
has_obo_namespace: molecular_function
id: GO:0019899
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: enzyme binding
annotated property: definition
annotated target: Binding to an enzyme, a protein with catalytic activity.
database_cross_reference: GOC:jl

protein domain specific binding
type: Class
subclass of: protein binding
definition: Binding to a specific domain of a protein.
has_exact_synonym: protein domain-specific binding
has_obo_namespace: molecular_function
id: GO:0019904
in_subset: goslim chembl

Axiom
annotated source: protein domain specific binding
annotated property: definition
annotated target: Binding to a specific domain of a protein.
database_cross_reference: GOC:go_curators

developmental maturation
type: Class
subclass of: biological_process
definition: A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
has_obo_namespace: biological_process
id: GO:0021700
in_subset: goslim chembl

Axiom
annotated source: developmental maturation
annotated property: definition
annotated target: A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
database_cross_reference: GOC:cls
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GO_REF:0000021

reproductive process
type: Class
subclass of: biological_process
definition: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
term tracker item: https://github.com/geneontology/go-ontology/issues/27054
created by: jl
creation date: 2012-09-19T15:56:06Z
has_alternative_id: GO:0019952
has_alternative_id: GO:0044702
has_alternative_id: GO:0050876
database_cross_reference: Wikipedia:Reproduction
has_obo_namespace: biological_process
has_related_synonym: single organism reproductive process
id: GO:0022414
in_subset: gocheck do not annotate
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: reproductive process
annotated property: definition
annotated target: A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete

cellular component assembly
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: biological_process
definition: The aggregation, arrangement and bonding together of a cellular component.
has_alternative_id: GO:0071844
has_exact_synonym: cell structure assembly
has_exact_synonym: cellular component assembly at cellular level
has_obo_namespace: biological_process
id: GO:0022607
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim pir

Axiom
annotated source: cellular component assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a cellular component.
database_cross_reference: GOC:isa_complete

protein-RNA complex assembly
type: Class
subclass of: protein-containing complex assembly
definition: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.
has_exact_synonym: RNA-protein complex assembly
has_exact_synonym: RNP complex assembly
has_exact_synonym: ribonucleoprotein complex assembly
has_obo_namespace: biological_process
id: GO:0022618
in_subset: goslim chembl

Axiom
annotated source: protein-RNA complex assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.
database_cross_reference: GOC:jl

transmembrane transporter activity
type: Class
subclass of: transporter activity
subclass of: Restriction
  on property: part of
  some values from: transmembrane transport
definition: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
has_alternative_id: GO:0005386
has_alternative_id: GO:0015563
has_alternative_id: GO:0015646
has_alternative_id: GO:0022891
has_alternative_id: GO:0022892
database_cross_reference: Reactome:R-HSA-1236947
database_cross_reference: Reactome:R-HSA-2142859
database_cross_reference: Reactome:R-HSA-2161500
database_cross_reference: Reactome:R-HSA-429036
database_cross_reference: Reactome:R-HSA-434650
database_cross_reference: Reactome:R-HSA-549129
database_cross_reference: Reactome:R-HSA-549279
database_cross_reference: Reactome:R-HSA-549304
database_cross_reference: Reactome:R-HSA-549322
database_cross_reference: Reactome:R-HSA-561041
database_cross_reference: Reactome:R-HSA-561054
database_cross_reference: Reactome:R-HSA-561072
database_cross_reference: Reactome:R-HSA-5638209
database_cross_reference: Reactome:R-HSA-5671707
database_cross_reference: Reactome:R-HSA-6784434
database_cross_reference: Reactome:R-HSA-6784436
database_cross_reference: Reactome:R-HSA-8954513
database_cross_reference: Reactome:R-HSA-9794270
database_cross_reference: Reactome:R-HSA-9794523
database_cross_reference: Reactome:R-HSA-9794830
database_cross_reference: Reactome:R-HSA-9795207
has_obo_namespace: molecular_function
has_related_synonym: substrate-specific transmembrane transporter activity
has_related_synonym: substrate-specific transporter activity
has_related_synonym: uptake permease activity
has_related_synonym: uptake transmembrane transporter activity
id: GO:0022857
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: transmembrane transporter activity
annotated property: definition
annotated target: Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
database_cross_reference: GOC:jid
database_cross_reference: GOC:mtg_transport
database_cross_reference: ISBN:0815340729

Egress of internalized antigen to the cytosol via sec61
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1236947

Growing HA is extruded from the cell by ABCC5
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2142859

abacavir [extracellular] => abacavir [cytosol]
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2161500

SLC2A9 transports Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-429036

MATEs mediate extrusion of xenobiotics
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-434650

OCT1 transports organic cations into hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549129

OCT2 mediates tubular uptake of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549279

OCT3 mediates renal clearance of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549304

OCT1 transports organic cations out of hepatic cells
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-549322

OAT1,2,3 transport organic anions with antiport of dicarboxylic acids
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561041

OCT2 mediates tubular secretion of organic cations in the kidney
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561054

OCT3 mediates renal uptake of organic cations
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-561072

Defective SLC2A9 does not transport Fru, Glc, urate
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5638209

Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5671707

An unknown carrier transports cytosolic glyoxylate to the peroxisome
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784434

An unknown carrier transports mitochondrial glyoxylate to the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-6784436

NAASP translocates from mitochondrial matrix to cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8954513

SLCO1A2 transports Cipro(1+) into the cytosol
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794270

SLC22A1 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794523

SLC22A8 transports Cipro into renal cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9794830

SLC22A1 transports Cipro into hepatic cell
type: Axiom
annotated source: transmembrane transporter activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9795207

cell differentiation
type: Class
subclass of: biological_process
definition: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
term tracker item: https://github.com/geneontology/go-ontology/issues/24390
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
id: GO:0030154
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: cell differentiation
annotated property: definition
annotated target: The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: ISBN:0198506732

low-density lipoprotein particle binding
type: Class
subclass of: protein-containing complex binding
definition: Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
has_exact_synonym: LDL binding
has_obo_namespace: molecular_function
id: GO:0030169
in_subset: goslim chembl

Axiom
annotated source: low-density lipoprotein particle binding
annotated property: definition
annotated target: Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
database_cross_reference: GOC:mah

extracellular matrix organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: Reactome:R-HSA-1474244
has_exact_synonym: extracellular matrix organisation
has_obo_namespace: biological_process
has_related_synonym: extracellular matrix organization and biogenesis
id: GO:0030198
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: extracellular matrix organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
database_cross_reference: GOC:mah

Extracellular matrix organization
type: Axiom
annotated source: extracellular matrix organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1474244

Axiom
annotated source: extracellular matrix organization
annotated property: has_related_synonym
annotated target: extracellular matrix organization and biogenesis
database_cross_reference: GOC:mah

enzyme regulator activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: protein binding
subclass of: Restriction
  on property: regulates
  some values from: catalytic activity
definition: A molecular function regulator that modulates a catalytic activity.
has_alternative_id: GO:0010576
has_exact_synonym: catalytic regulator activity
has_exact_synonym: enzyme modulator
has_narrow_synonym: metalloenzyme regulator activity
has_obo_namespace: molecular_function
id: GO:0030234
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon
in_subset: goslim yeast
comment: This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification.

Axiom
annotated source: enzyme regulator activity
annotated property: definition
annotated target: A molecular function regulator that modulates a catalytic activity.
database_cross_reference: GOC:pdt

Axiom
annotated source: enzyme regulator activity
annotated property: has_exact_synonym
annotated target: catalytic regulator activity
database_cross_reference: GOC:dph

carbohydrate binding
type: Class
subclass of: molecular_function
definition: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
has_alternative_id: GO:0005529
has_exact_synonym: sugar binding
has_obo_namespace: molecular_function
has_related_synonym: selectin
id: GO:0030246
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: carbohydrate binding
annotated property: definition
annotated target: Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
database_cross_reference: GOC:mah

external encapsulating structure
type: Class
subclass of: cellular_component
subclass of: Restriction
  on property: part of
  some values from: cellular_component
definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
has_obo_namespace: cellular_component
id: GO:0030312
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.

Axiom
annotated source: external encapsulating structure
annotated property: definition
annotated target: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
database_cross_reference: GOC:go_curators

triplet codon-amino acid adaptor activity
type: Class
subclass of: mRNA binding
subclass of: Restriction
  on property: part of
  some values from: translation
subclass of: Restriction
  on property: has part
  some values from: molecular_function
definition: The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.
has_obo_namespace: molecular_function
has_related_synonym: tRNA
has_related_synonym: transfer RNA
id: GO:0030533
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim yeast
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.

Axiom
annotated source: triplet codon-amino acid adaptor activity
annotated property: definition
annotated target: The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.
database_cross_reference: GOC:hjd
database_cross_reference: GOC:mtg_MIT_16mar07
database_cross_reference: ISBN:0198506732

adenyl nucleotide binding
type: Class
subclass of: nucleotide binding
definition: Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate.
has_obo_namespace: molecular_function
id: GO:0030554
in_subset: goslim chembl

Axiom
annotated source: adenyl nucleotide binding
annotated property: definition
annotated target: Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate.
database_cross_reference: ISBN:0198506732

protein-macromolecule adaptor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: protein binding
definition: An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/18655
term tracker item: https://github.com/geneontology/go-ontology/issues/19409
term tracker item: https://github.com/geneontology/go-ontology/issues/22925
has_broad_synonym: protein complex scaffold activity
has_broad_synonym: protein-containing complex scaffold activity
database_cross_reference: Reactome:R-HSA-3780997
database_cross_reference: Reactome:R-HSA-3781001
database_cross_reference: Reactome:R-HSA-3781021
database_cross_reference: Reactome:R-HSA-3781023
database_cross_reference: Reactome:R-HSA-8871366
database_cross_reference: Reactome:R-HSA-8871376
has_exact_synonym: protein binding, bridging
has_narrow_synonym: protein-protein adaptor
has_obo_namespace: molecular_function
has_related_synonym: protein recruiting activity
id: GO:0030674
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: definition
annotated target: An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw

PPP1R3C binds to glycogen:GYG2:GYS2
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3780997

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781001

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781021

PPP1R3C binds to glycogen:GYG1:GYS1
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-3781023

p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8871366

p-Y389,400-RUFY1 binds PI3P
type: Axiom
annotated source: protein-macromolecule adaptor activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8871376

cytoskeleton-dependent intracellular transport
type: Class
subclass of: transport
subclass of: Restriction
  on property: part of
  some values from: biological_process
subclass of: Restriction
  on property: occurs in
  some values from: intracellular anatomical structure
definition: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
has_obo_namespace: biological_process
id: GO:0030705
in_subset: goslim chembl
in_subset: goslim drosophila

Axiom
annotated source: cytoskeleton-dependent intracellular transport
annotated property: definition
annotated target: The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
database_cross_reference: GOC:mah

beta-2-microglobulin binding
type: Class
subclass of: protein binding
definition: Binding to beta-2-microglobulin.
has_obo_namespace: molecular_function
id: GO:0030881
in_subset: goslim chembl

Axiom
annotated source: beta-2-microglobulin binding
annotated property: definition
annotated target: Binding to beta-2-microglobulin.
database_cross_reference: GOC:mah

extracellular matrix
type: Class
subclass of: external encapsulating structure
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
has_alternative_id: GO:0005578
database_cross_reference: NIF_Subcellular:nlx_subcell_20090513
database_cross_reference: Wikipedia:Extracellular_matrix
has_exact_synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote

Axiom
annotated source: extracellular matrix
annotated property: definition
annotated target: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rph
database_cross_reference: PMID:21123617
database_cross_reference: PMID:28089324
database_cross_reference: PMID:33605520

cytoplasmic vesicle
type: Class
subclass of: organelle
subclass of: Restriction
  on property: part of
  some values from: cytoplasm
subclass of: Restriction
  on property: has part
  some values from: membrane
definition: A vesicle found in the cytoplasm of a cell.
has_alternative_id: GO:0016023
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic membrane bounded vesicle
has_related_synonym: cytoplasmic membrane-enclosed vesicle
has_related_synonym: cytoplasmic, membrane-bounded vesicle
id: GO:0031410
in_subset: goslim agr
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim yeast

Axiom
annotated source: cytoplasmic vesicle
annotated property: definition
annotated target: A vesicle found in the cytoplasm of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
database_cross_reference: GOC:vesicles

zymogen activation
type: Class
subclass of: protein processing
definition: The proteolytic processing of an inactive enzyme to an active form.
has_exact_synonym: zymogen activation by proteolytic cleavage
has_obo_namespace: biological_process
id: GO:0031638
in_subset: goslim chembl

Axiom
annotated source: zymogen activation
annotated property: definition
annotated target: The proteolytic processing of an inactive enzyme to an active form.
database_cross_reference: GOC:hjd

plasminogen activation
type: Class
subclass of: zymogen activation
definition: The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
has_exact_synonym: cleavage of plasminogen to plasmin
has_obo_namespace: biological_process
id: GO:0031639
in_subset: goslim chembl

Axiom
annotated source: plasminogen activation
annotated property: definition
annotated target: The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
database_cross_reference: PMID:9548733

insulin-like growth factor I binding
type: Class
subclass of: insulin-like growth factor binding
definition: Binding to insulin-like growth factor I.
has_exact_synonym: IGF-I binding
has_obo_namespace: molecular_function
id: GO:0031994
in_subset: goslim chembl

Axiom
annotated source: insulin-like growth factor I binding
annotated property: definition
annotated target: Binding to insulin-like growth factor I.
database_cross_reference: GOC:mah

insulin-like growth factor II binding
type: Class
subclass of: insulin-like growth factor binding
definition: Binding to insulin-like growth factor II.
has_exact_synonym: IGF-II binding
has_obo_namespace: molecular_function
id: GO:0031995
in_subset: goslim chembl

Axiom
annotated source: insulin-like growth factor II binding
annotated property: definition
annotated target: Binding to insulin-like growth factor II.
database_cross_reference: GOC:mah

ubiquitin-like protein binding
type: Class
subclass of: protein binding
definition: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.
has_exact_synonym: small conjugating protein binding
has_obo_namespace: molecular_function
id: GO:0032182
in_subset: goslim chembl
in_subset: goslim yeast

Axiom
annotated source: ubiquitin-like protein binding
annotated property: definition
annotated target: Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein.
database_cross_reference: GOC:mah

Axiom
annotated source: ubiquitin-like protein binding
annotated property: has_exact_synonym
annotated target: small conjugating protein binding
database_cross_reference: GOC:dph

transposition
type: Class
subclass of: biological_process
definition: Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.
database_cross_reference: Wikipedia:Transposon
has_obo_namespace: biological_process
id: GO:0032196
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: transposition
annotated property: definition
annotated target: Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.
database_cross_reference: ISBN:1555812090
database_cross_reference: PMID:14682279
database_cross_reference: PMID:25893143

methylation
type: Class
subclass of: metabolic process
definition: The process in which a methyl group is covalently attached to a molecule.
database_cross_reference: Reactome:R-HSA-156581
database_cross_reference: Wikipedia:Methylation
has_obo_namespace: biological_process
id: GO:0032259
in_subset: goslim chembl

Axiom
annotated source: methylation
annotated property: definition
annotated target: The process in which a methyl group is covalently attached to a molecule.
database_cross_reference: GOC:mah

Methylation
type: Axiom
annotated source: methylation
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-156581

regulation of protein localization
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: biological_process
definition: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
term tracker item: https://github.com/geneontology/go-ontology/issues/22021
created by: jl
creation date: 2015-01-20T14:32:14Z
has_alternative_id: GO:1903827
has_exact_synonym: regulation of cellular protein localisation
has_exact_synonym: regulation of cellular protein localization
has_exact_synonym: regulation of protein localisation
has_obo_namespace: biological_process
id: GO:0032880
in_subset: goslim chembl

Axiom
annotated source: regulation of protein localization
annotated property: definition
annotated target: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb

Axiom
annotated source: regulation of protein localization
annotated property: has_exact_synonym
annotated target: regulation of cellular protein localisation
database_cross_reference: GOC:TermGenie

Axiom
annotated source: regulation of protein localization
annotated property: has_exact_synonym
annotated target: regulation of protein localisation
database_cross_reference: GOC:mah

protein-containing complex
type: Class
subclass of: cellular_component
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
has_alternative_id: GO:0043234
has_exact_synonym: macromolecular complex
has_exact_synonym: macromolecule complex
has_exact_synonym: protein containing complex
has_narrow_synonym: protein complex
has_narrow_synonym: protein-protein complex
has_obo_namespace: cellular_component
id: GO:0032991
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pir
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.

Axiom
annotated source: protein-containing complex
annotated property: definition
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah

cis-stilbene-oxide hydrolase activity
type: Class
subclass of: epoxide hydrolase activity
definition: Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
term tracker item: https://github.com/geneontology/go-ontology/issues/27074
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: arene-oxide hydratase activity
has_broad_synonym: aryl epoxide hydrase activity
has_broad_synonym: epoxide hydrase activity
has_broad_synonym: epoxide hydratase activity
database_cross_reference: EC:3.3.2.9
database_cross_reference: MetaCyc:3.3.2.9-RXN
database_cross_reference: RHEA:23900
database_cross_reference: Reactome:R-HSA-5694077
has_narrow_synonym: benzo(a)pyrene-4,5-epoxide hydratase activity
has_narrow_synonym: benzo[a]pyrene-4,5-oxide hydratase activity
has_narrow_synonym: microsomal epoxide hydrase activity
has_narrow_synonym: microsomal epoxide hydratase activity
has_narrow_synonym: microsomal epoxide hydrolase activity
has_obo_namespace: molecular_function
has_related_synonym: cis-epoxide hydrolase activity
has_related_synonym: mEH
id: GO:0033961
in_subset: goslim chembl

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: definition
annotated target: Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_broad_synonym
annotated target: arene-oxide hydratase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_broad_synonym
annotated target: aryl epoxide hydrase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_broad_synonym
annotated target: epoxide hydrase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_broad_synonym
annotated target: epoxide hydratase activity
database_cross_reference: EC:3.3.2.9

EPHX1 hydrates BaP4,5O to BaP4,5-DHD
type: Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694077

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: benzo(a)pyrene-4,5-epoxide hydratase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: benzo[a]pyrene-4,5-oxide hydratase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: microsomal epoxide hydrase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: microsomal epoxide hydratase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_narrow_synonym
annotated target: microsomal epoxide hydrolase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_related_synonym
annotated target: cis-epoxide hydrolase activity
database_cross_reference: EC:3.3.2.9

Axiom
annotated source: cis-stilbene-oxide hydrolase activity
annotated property: has_related_synonym
annotated target: mEH
database_cross_reference: EC:3.3.2.9

cell junction organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.
has_exact_synonym: cell junction assembly and maintenance
has_exact_synonym: cell junction organisation
has_obo_namespace: biological_process
has_related_synonym: cell junction biogenesis
id: GO:0034330
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: cell junction organization
annotated property: definition
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: cell junction organization
annotated property: has_exact_synonym
annotated target: cell junction organisation
database_cross_reference: GOC:mah

nucleobase-containing compound catabolic process
type: Class
subclass of: catabolic process
definition: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid breakdown
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid degradation
has_obo_namespace: biological_process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
id: GO:0034655
in_subset: goslim chembl

Axiom
annotated source: nucleobase-containing compound catabolic process
annotated property: definition
annotated target: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:mah

Axiom
annotated source: nucleobase-containing compound catabolic process
annotated property: has_related_synonym
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

glutamate receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to a glutamate receptor.
has_obo_namespace: molecular_function
id: GO:0035254
in_subset: goslim chembl

Axiom
annotated source: glutamate receptor binding
annotated property: definition
annotated target: Binding to a glutamate receptor.
database_cross_reference: GOC:bf

response to stilbenoid
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
created by: bf
creation date: 2011-01-12T10:37:33Z
has_obo_namespace: biological_process
id: GO:0035634
in_subset: goslim chembl

Axiom
annotated source: response to stilbenoid
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.
database_cross_reference: GOC:yaf
database_cross_reference: Wikipedia:Stilbenoid

protein modification process
type: Class
subclass of: metabolic process
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
term tracker item: https://github.com/geneontology/go-ontology/issues/23112
created by: bf
creation date: 2012-04-26T01:47:12Z
has_alternative_id: GO:0006464
has_exact_synonym: cellular protein modification process
has_exact_synonym: process resulting in protein modification
has_exact_synonym: protein modification
has_obo_namespace: biological_process
id: GO:0036211
in_subset: gocheck do not annotate
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim prokaryote

Axiom
annotated source: protein modification process
annotated property: definition
annotated target: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl

Axiom
annotated source: protein modification process
annotated property: has_exact_synonym
annotated target: protein modification
database_cross_reference: GOC:bf

signaling receptor activity
type: Class
subclass of: molecular_function
definition: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
created by: bf
creation date: 2011-08-01T02:45:27Z
has_alternative_id: GO:0004872
has_alternative_id: GO:0019041
has_broad_synonym: receptor activity
has_exact_synonym: receptor activity involved in signal transduction
has_exact_synonym: signalling receptor activity
has_obo_namespace: molecular_function
id: GO:0038023
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: signaling receptor activity
annotated property: definition
annotated target: Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
database_cross_reference: GOC:bf
database_cross_reference: GOC:signaling

Axiom
annotated source: signaling receptor activity
annotated property: has_exact_synonym
annotated target: receptor activity involved in signal transduction
database_cross_reference: GOC:bf

growth
type: Class
subclass of: biological_process
definition: The increase in size or mass of an entire organism, a part of an organism or a cell.
has_alternative_id: GO:0048590
has_obo_namespace: biological_process
has_related_synonym: growth pattern
has_related_synonym: non-developmental growth
id: GO:0040007
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim pir
in_subset: goslim plant
comment: See also the biological process term 'cell growth ; GO:0016049'.

Axiom
annotated source: growth
annotated property: definition
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:ma

Axiom
annotated source: growth
annotated property: has_related_synonym
annotated target: non-developmental growth
database_cross_reference: GOC:mah

locomotion
type: Class
subclass of: biological_process
definition: Self-propelled movement of a cell or organism from one location to another.
has_obo_namespace: biological_process
id: GO:0040011
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: locomotion
annotated property: definition
annotated target: Self-propelled movement of a cell or organism from one location to another.
database_cross_reference: GOC:dgh

chemoattractant activity
type: Class
subclass of: receptor ligand activity
subclass of: Restriction
  on property: part of
  some values from: locomotion
definition: Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
has_broad_synonym: attractant
has_obo_namespace: molecular_function
id: GO:0042056
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: chemoattractant activity
annotated property: definition
annotated target: Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732

ribosome biogenesis
type: Class
subclass of: biological_process
definition: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
has_alternative_id: GO:0007046
has_exact_synonym: ribosome biogenesis and assembly
has_obo_namespace: biological_process
id: GO:0042254
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: ribosome biogenesis
annotated property: definition
annotated target: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
database_cross_reference: GOC:ma
database_cross_reference: PMID:26404467
database_cross_reference: Wikipedia:Ribosome_biogenesis

peptide binding
type: Class
subclass of: molecular_function
definition: Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
has_obo_namespace: molecular_function
id: GO:0042277
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: peptide binding
annotated property: definition
annotated target: Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
database_cross_reference: GOC:jl

histone binding
type: Class
subclass of: protein binding
definition: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
term tracker item: https://github.com/geneontology/go-ontology/issues/23106
has_obo_namespace: molecular_function
has_related_synonym: histone-specific chaperone activity
id: GO:0042393
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: histone binding
annotated property: definition
annotated target: Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
database_cross_reference: GOC:jl
database_cross_reference: PMID:16209651
database_cross_reference: PMID:30212449
database_cross_reference: PMID:9305837

hormone binding
type: Class
subclass of: molecular_function
definition: Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.
has_obo_namespace: molecular_function
id: GO:0042562
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: hormone binding
annotated property: definition
annotated target: Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.
database_cross_reference: GOC:jl

homeostatic process
type: Class
subclass of: biological_process
definition: Any biological process involved in the maintenance of an internal steady state. Homeostasis allows cells and organisms to maintain stable internal conditions despite varying external conditions.
term tracker item: https://github.com/geneontology/go-ontology/issues/31175
has_alternative_id: GO:0032844
has_alternative_id: GO:0032845
has_alternative_id: GO:0032846
has_exact_synonym: homeostasis
has_narrow_synonym: activation of homeostatic process
has_narrow_synonym: inhibition of homeostatic process
has_obo_namespace: biological_process
has_related_synonym: negative regulation of homeostatic process
has_related_synonym: positive regulation of homeostatic process
has_related_synonym: regulation of homeostatic process
id: GO:0042592
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim mouse

Axiom
annotated source: homeostatic process
annotated property: definition
annotated target: Any biological process involved in the maintenance of an internal steady state. Homeostasis allows cells and organisms to maintain stable internal conditions despite varying external conditions.
database_cross_reference: PMID:26265027

peptide antigen binding
type: Class
subclass of: antigen binding
subclass of: peptide binding
definition: Binding to an antigen peptide.
has_alternative_id: GO:0042606
has_alternative_id: GO:0042607
has_narrow_synonym: endogenous peptide antigen binding
has_narrow_synonym: exogenous peptide antigen binding
has_obo_namespace: molecular_function
id: GO:0042605
in_subset: goslim chembl
comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule.

Axiom
annotated source: peptide antigen binding
annotated property: definition
annotated target: Binding to an antigen peptide.
database_cross_reference: GOC:add
database_cross_reference: GOC:jl
database_cross_reference: GOC:rv

identical protein binding
type: Class
subclass of: protein binding
definition: Binding to an identical protein or proteins.
has_exact_synonym: isoform-specific homophilic binding
has_obo_namespace: molecular_function
has_related_synonym: protein homopolymerization
id: GO:0042802
in_subset: goslim chembl

Axiom
annotated source: identical protein binding
annotated property: definition
annotated target: Binding to an identical protein or proteins.
database_cross_reference: GOC:jl

Axiom
annotated source: identical protein binding
annotated property: has_exact_synonym
annotated target: isoform-specific homophilic binding
database_cross_reference: PMID:17889655

protein homodimerization activity
type: Class
subclass of: identical protein binding
definition: Binding to an identical protein to form a homodimer.
has_broad_synonym: dimerization activity
has_obo_namespace: molecular_function
id: GO:0042803
in_subset: goslim chembl

Axiom
annotated source: protein homodimerization activity
annotated property: definition
annotated target: Binding to an identical protein to form a homodimer.
database_cross_reference: GOC:jl

Wnt receptor activity
type: Class
subclass of: signaling receptor activity
subclass of: Restriction
  on property: part of
  some values from: signal transduction
subclass of: Restriction
  on property: has part
  some values from: Wnt-protein binding
definition: Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
term tracker item: https://github.com/geneontology/go-ontology/issues/23056
has_exact_synonym: Wnt-activated receptor activity
has_obo_namespace: molecular_function
has_related_synonym: frizzled receptor activity
has_related_synonym: frizzled-2 receptor activity
id: GO:0042813
in_subset: goslim chembl

Axiom
annotated source: Wnt receptor activity
annotated property: definition
annotated target: Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
database_cross_reference: GOC:go_curators

ATP-dependent protein binding
type: Class
subclass of: protein binding
definition: Binding to a protein or protein complex using energy from ATP hydrolysis.
has_obo_namespace: molecular_function
id: GO:0043008
in_subset: goslim chembl

Axiom
annotated source: ATP-dependent protein binding
annotated property: definition
annotated target: Binding to a protein or protein complex using energy from ATP hydrolysis.
database_cross_reference: GOC:jl

positive regulation of apoptotic process
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: programmed cell death
subclass of: Restriction
  on property: positively regulates
  some values from: programmed cell death
definition: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
database_cross_reference: Reactome:R-HSA-193648
database_cross_reference: Reactome:R-HSA-205043
has_exact_synonym: up regulation of apoptosis
has_exact_synonym: up-regulation of apoptosis
has_exact_synonym: upregulation of apoptosis
has_narrow_synonym: activation of apoptosis
has_narrow_synonym: positive regulation of apoptosis
has_narrow_synonym: stimulation of apoptosis
has_obo_namespace: biological_process
has_related_synonym: pro-apoptosis
id: GO:0043065
in_subset: goslim chembl
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.

Axiom
annotated source: positive regulation of apoptotic process
annotated property: definition
annotated target: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mtg_apoptosis

NRAGE signals death through JNK
type: Axiom
annotated source: positive regulation of apoptotic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-193648

NRIF signals cell death from the nucleus
type: Axiom
annotated source: positive regulation of apoptotic process
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-205043

positive regulation of catalytic activity
type: Class
subclass of: regulation of catalytic activity
subclass of: Restriction
  on property: positively regulates
  some values from: catalytic activity
definition: Any process that activates or increases the activity of an enzyme.
has_alternative_id: GO:0048554
has_exact_synonym: positive regulation of enzyme activity
has_exact_synonym: up regulation of enzyme activity
has_exact_synonym: up-regulation of enzyme activity
has_exact_synonym: upregulation of enzyme activity
has_narrow_synonym: activation of enzyme activity
has_narrow_synonym: activation of metalloenzyme activity
has_narrow_synonym: positive regulation of metalloenzyme activity
has_narrow_synonym: stimulation of enzyme activity
has_narrow_synonym: stimulation of metalloenzyme activity
has_narrow_synonym: up regulation of metalloenzyme activity
has_narrow_synonym: up-regulation of metalloenzyme activity
has_narrow_synonym: upregulation of metalloenzyme activity
has_obo_namespace: biological_process
id: GO:0043085
in_subset: gocheck obsoletion candidate
in_subset: goslim chembl

Axiom
annotated source: positive regulation of catalytic activity
annotated property: definition
annotated target: Any process that activates or increases the activity of an enzyme.
database_cross_reference: GOC:ebc
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw

Axiom
annotated source: positive regulation of catalytic activity
annotated property: has_exact_synonym
annotated target: positive regulation of enzyme activity
database_cross_reference: GOC:tb

ion binding
type: Class
subclass of: molecular_function
definition: Binding to an ion, a charged atoms or groups of atoms.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_obo_namespace: molecular_function
has_related_synonym: atom binding
id: GO:0043167
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast

Axiom
annotated source: ion binding
annotated property: definition
annotated target: Binding to an ion, a charged atoms or groups of atoms.
database_cross_reference: GOC:jl

organelle
type: Class
subclass of: cellular_component
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: NIF_Subcellular:sao1539965131
database_cross_reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
id: GO:0043226
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon

Axiom
annotated source: organelle
annotated property: definition
annotated target: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: GOC:go_curators

pigmentation
type: Class
subclass of: biological_process
definition: The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
has_obo_namespace: biological_process
id: GO:0043473
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: pigmentation
annotated property: definition
annotated target: The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
database_cross_reference: GOC:jl

hemolysis in another organism
type: Class
subclass of: cytolysis
definition: The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another.
created by: jl
creation date: 2009-09-04T03:36:00Z
has_alternative_id: GO:1990142
has_exact_synonym: hemolysis in other organism
has_exact_synonym: hemolysis of RBCs in other organism
has_exact_synonym: hemolysis of cells in other organism
has_exact_synonym: hemolysis of erythrocytes in other organism
has_exact_synonym: hemolysis of red blood cells in other organism
has_narrow_synonym: envenomation resulting in hemolysis in another organism
has_narrow_synonym: envenomation resulting in hemolysis in other organism
has_obo_namespace: biological_process
id: GO:0044179
in_subset: goslim chembl

Axiom
annotated source: hemolysis in another organism
annotated property: definition
annotated target: The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another.
database_cross_reference: GOC:jl
database_cross_reference: PMID:21590705

Axiom
annotated source: hemolysis in another organism
annotated property: has_exact_synonym
annotated target: hemolysis of cells in other organism
database_cross_reference: GOC:bf

protein folding chaperone
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: protein folding
subclass of: Restriction
  on property: has part
  some values from: unfolded protein binding
definition: Binding to a protein or a protein-containing complex to assist the protein folding process.
created by: jl
creation date: 2009-09-25T11:33:48Z
has_broad_synonym: chaperone activity
database_cross_reference: Reactome:R-HSA-9018785
database_cross_reference: Reactome:R-HSA-9855212
database_cross_reference: Reactome:R-HSA-9865893
database_cross_reference: Reactome:R-HSA-9866253
has_exact_synonym: protein binding involved in protein folding
has_obo_namespace: molecular_function
id: GO:0044183
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: protein folding chaperone
annotated property: definition
annotated target: Binding to a protein or a protein-containing complex to assist the protein folding process.
database_cross_reference: GOC:mtg_cambridge_2009

RHOBTB2 binds GTP
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9018785

SDHA binds to SDHB
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9855212

MT-CYB is translated
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9865893

apo-UQCRFS1 binds LYRM7
type: Axiom
annotated source: protein folding chaperone
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9866253

small molecule metabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
created by: jl
creation date: 2010-01-26T12:05:20Z
has_exact_synonym: small molecule metabolism
has_obo_namespace: biological_process
id: GO:0044281
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.

Axiom
annotated source: small molecule metabolic process
annotated property: definition
annotated target: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
database_cross_reference: GOC:curators
database_cross_reference: GOC:pde
database_cross_reference: GOC:vw

transmembrane transporter binding
type: Class
subclass of: protein binding
definition: Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
term tracker item: https://github.com/geneontology/go-ontology/issues/21331
created by: jl
creation date: 2010-08-04T12:52:59Z
has_narrow_synonym: ion channel binding
has_obo_namespace: molecular_function
id: GO:0044325
in_subset: goslim chembl

Axiom
annotated source: transmembrane transporter binding
annotated property: definition
annotated target: Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:jl
database_cross_reference: PMID:33199372

biological process involved in symbiotic interaction
type: Class
subclass of: biological_process
definition: A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
term tracker item: https://github.com/geneontology/go-ontology/issues/14807
term tracker item: https://github.com/geneontology/go-ontology/issues/20191
has_alternative_id: GO:0043298
has_alternative_id: GO:0044404
has_alternative_id: GO:0072519
has_alternative_id: GO:0085031
has_narrow_synonym: commensalism
has_narrow_synonym: host-pathogen interaction
has_narrow_synonym: parasitism
has_obo_namespace: biological_process
has_related_synonym: symbiosis
has_related_synonym: symbiosis, encompassing mutualism through parasitism
has_related_synonym: symbiotic interaction
has_related_synonym: symbiotic interaction between host and organism
has_related_synonym: symbiotic interaction between organisms
has_related_synonym: symbiotic interaction between species
has_related_synonym: symbiotic process
id: GO:0044403
in_subset: goslim chembl

Axiom
annotated source: biological process involved in symbiotic interaction
annotated property: definition
annotated target: A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
database_cross_reference: GOC:cc
database_cross_reference: PMID:31257129

virion component
type: Class
subclass of: cellular_component
definition: Any constituent part of a virion, a complete fully infectious extracellular virus particle.
has_alternative_id: GO:0019012
database_cross_reference: Wikipedia:Virus
has_exact_synonym: virion part
has_obo_namespace: cellular_component
has_related_synonym: complete virus particle
has_related_synonym: virion
id: GO:0044423
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir

Axiom
annotated source: virion component
annotated property: definition
annotated target: Any constituent part of a virion, a complete fully infectious extracellular virus particle.
database_cross_reference: GOC:jl

protein-containing complex binding
type: Class
subclass of: molecular_function
definition: Binding to a macromolecular complex.
created by: jl
creation date: 2014-12-16T11:38:58Z
has_alternative_id: GO:0032403
has_exact_synonym: protein complex binding
has_obo_namespace: molecular_function
has_related_synonym: macromolecular complex binding
id: GO:0044877
in_subset: goslim chembl

Axiom
annotated source: protein-containing complex binding
annotated property: definition
annotated target: Binding to a macromolecular complex.
database_cross_reference: GOC:jl

TRAIL binding
type: Class
subclass of: protein binding
definition: Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.
has_exact_synonym: Apo-2L binding
has_obo_namespace: molecular_function
id: GO:0045569
in_subset: goslim chembl

Axiom
annotated source: TRAIL binding
annotated property: definition
annotated target: Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.
database_cross_reference: GOC:go_curators
database_cross_reference: PMID:9082980

response to antibiotic
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
database_cross_reference: Reactome:R-HSA-9639775
has_obo_namespace: biological_process
has_related_synonym: antibiotic susceptibility/resistance
id: GO:0046677
in_subset: goslim chembl

Axiom
annotated source: response to antibiotic
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
database_cross_reference: GOC:ai
database_cross_reference: GOC:ef

Antimicrobial action and antimicrobial resistance in Mtb
type: Axiom
annotated source: response to antibiotic
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9639775

host cell surface receptor binding
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part of
  some values from: biological process involved in symbiotic interaction
definition: Binding to a receptor on the host cell surface.
has_obo_namespace: molecular_function
has_related_synonym: cell surface antigen activity, host-interacting
has_related_synonym: cell surface receptor ligand
id: GO:0046789
in_subset: goslim chembl

Axiom
annotated source: host cell surface receptor binding
annotated property: definition
annotated target: Binding to a receptor on the host cell surface.
database_cross_reference: GOC:ai
database_cross_reference: PMID:11511370

protein heterodimerization activity
type: Class
subclass of: protein binding
definition: Binding to a nonidentical protein to form a heterodimer.
has_obo_namespace: molecular_function
id: GO:0046982
in_subset: goslim chembl

Axiom
annotated source: protein heterodimerization activity
annotated property: definition
annotated target: Binding to a nonidentical protein to form a heterodimer.
database_cross_reference: GOC:ai

monoacylglycerol lipase activity
type: Class
subclass of: lipase activity
definition: Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/28339
has_broad_synonym: acylglycerol lipase activity
database_cross_reference: EC:3.1.1.23
database_cross_reference: MetaCyc:RXN-19280
database_cross_reference: RHEA:15245
database_cross_reference: Reactome:R-HSA-1482543
database_cross_reference: Reactome:R-HSA-163595
database_cross_reference: Reactome:R-HSA-192422
database_cross_reference: Reactome:R-HSA-192425
database_cross_reference: Reactome:R-HSA-192430
database_cross_reference: Reactome:R-HSA-192434
database_cross_reference: Reactome:R-HSA-192475
database_cross_reference: Reactome:R-HSA-426032
database_cross_reference: Reactome:R-HSA-426043
database_cross_reference: Reactome:R-HSA-5694462
has_obo_namespace: molecular_function
has_related_synonym: fatty acyl monoester lipase activity
has_related_synonym: glycerol-ester acylhydrolase activity
has_related_synonym: monoacylglycerol hydrolase activity
has_related_synonym: monoacylglycerolipase activity
has_related_synonym: monoglyceridase activity
has_related_synonym: monoglyceride hydrolase activity
has_related_synonym: monoglyceride lipase activity
has_related_synonym: monoglyceridyllipase activity
id: GO:0047372
in_subset: goslim chembl
broad match: http://purl.uniprot.org/enzyme/3.1.1.79

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: definition
annotated target: Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
database_cross_reference: RHEA:15245

2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-1482543

2-acylglycerol + H2O -> glycerol + fatty acid
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-163595

Digestion of triacylglycerols by extracellular PTL:colipase
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192422

Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192425

Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192430

Digestion of diacylglycerols by extracellular PTL:colipase
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192434

Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-192475

DAG is metabolized by DAGL to 2-AG
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-426032

2-AG hydrolysis to arachidonate by MAGL
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-426043

ABHD6,12 hydrolyse 3AG
type: Axiom
annotated source: monoacylglycerol lipase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5694462

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: fatty acyl monoester lipase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: glycerol-ester acylhydrolase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoacylglycerol hydrolase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoacylglycerolipase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoglyceridase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoglyceride hydrolase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoglyceride lipase activity
database_cross_reference: EC:3.1.1.23

Axiom
annotated source: monoacylglycerol lipase activity
annotated property: has_related_synonym
annotated target: monoglyceridyllipase activity
database_cross_reference: EC:3.1.1.23

fatty acyl-CoA hydrolase activity
type: Class
subclass of: hydrolase activity, acting on ester bonds
definition: Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/26441
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_alternative_id: GO:0008778
has_alternative_id: GO:0016291
has_alternative_id: GO:0016292
has_broad_synonym: acyl-CoA hydrolase activity
database_cross_reference: EC:3.1.2.20
database_cross_reference: MetaCyc:ACYL-COA-HYDROLASE-RXN
database_cross_reference: RHEA:16781
database_cross_reference: Reactome:R-HSA-5690042
database_cross_reference: Reactome:R-HSA-5690043
database_cross_reference: Reactome:R-HSA-5690066
has_exact_synonym: acyl-CoA thioesterase activity
has_exact_synonym: acyl-CoA thiolesterase activity
has_narrow_synonym: acyl-CoA thioesterase I activity
has_narrow_synonym: acyl-CoA thioesterase II activity
has_obo_namespace: molecular_function
has_related_synonym: acyl coenzyme A hydrolase activity
has_related_synonym: acyl coenzyme A thioesterase activity
has_related_synonym: thioesterase B
has_related_synonym: thioesterase II
id: GO:0047617
in_subset: goslim chembl

Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: definition
annotated target: Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
database_cross_reference: RHEA:16781

Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA
type: Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690042

Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA
type: Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690043

ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA
type: Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5690066

Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: has_related_synonym
annotated target: acyl coenzyme A hydrolase activity
database_cross_reference: EC:3.1.2.20

Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: has_related_synonym
annotated target: acyl coenzyme A thioesterase activity
database_cross_reference: EC:3.1.2.20

Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: has_related_synonym
annotated target: thioesterase B
database_cross_reference: EC:3.1.2.20

Axiom
annotated source: fatty acyl-CoA hydrolase activity
annotated property: has_related_synonym
annotated target: thioesterase II
database_cross_reference: EC:3.1.2.20

bile-salt sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.8.2.14
database_cross_reference: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:14013
has_exact_synonym: bile-salt sulphotransferase activity
has_narrow_synonym: BAST I activity
has_narrow_synonym: bile acid sulfotransferase I activity
has_narrow_synonym: glycolithocholate sulfotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity
has_related_synonym: bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity
has_related_synonym: bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity
id: GO:0047704
in_subset: goslim chembl

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
database_cross_reference: EC:2.8.2.14
database_cross_reference: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_narrow_synonym
annotated target: BAST I activity
database_cross_reference: EC:2.8.2.14

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_narrow_synonym
annotated target: bile acid sulfotransferase I activity
database_cross_reference: EC:2.8.2.14

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_narrow_synonym
annotated target: glycolithocholate sulfotransferase activity
database_cross_reference: EC:2.8.2.14

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity
database_cross_reference: EC:2.8.2.14

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_related_synonym
annotated target: bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity
database_cross_reference: EC:2.8.2.14

Axiom
annotated source: bile-salt sulfotransferase activity
annotated property: has_related_synonym
annotated target: bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity
database_cross_reference: EC:2.8.2.14

flavonol 3-sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:2.8.2.25
database_cross_reference: KEGG_REACTION:R02159
database_cross_reference: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:13453
has_exact_synonym: 3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity
has_exact_synonym: flavonol 3-sulphotransferase activity
has_obo_namespace: molecular_function
id: GO:0047894
in_subset: goslim chembl

Axiom
annotated source: flavonol 3-sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate.
database_cross_reference: EC:2.8.2.25
database_cross_reference: RHEA:13453

Axiom
annotated source: flavonol 3-sulfotransferase activity
annotated property: has_exact_synonym
annotated target: 3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity
database_cross_reference: EC:2.8.2.25
has_synonym_type: Systematic synonym

receptor ligand activity
type: Class
subclass of: signaling receptor binding
subclass of: Restriction
  on property: part of
  some values from: signal transduction
subclass of: Restriction
  on property: has part
  some values from: protein binding
subclass of: Restriction
  on property: regulates
  some values from: signaling receptor activity
subclass of: Restriction
  on property: positively regulates
  some values from: signaling receptor activity
definition: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
term tracker item: https://github.com/geneontology/go-ontology/issues/14220
term tracker item: https://github.com/geneontology/go-ontology/issues/27076
created by: mah
creation date: 2010-09-13T04:51:59Z
has_alternative_id: GO:0071884
has_broad_synonym: agonist
has_broad_synonym: signaling molecule
database_cross_reference: Reactome:R-HSA-381612
database_cross_reference: Reactome:R-HSA-8848663
has_exact_synonym: signaling receptor ligand activity
has_obo_namespace: molecular_function
has_related_synonym: receptor agonist activity
id: GO:0048018
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic

Axiom
annotated source: receptor ligand activity
annotated property: definition
annotated target: The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins).
database_cross_reference: GOC:kv
database_cross_reference: GOC:molecular_function_refactoring
database_cross_reference: GOC:pdt

GLP1R binds GLP1
type: Axiom
annotated source: receptor ligand activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-381612

ADIPOQ trimer binds ADIPOR dimers
type: Axiom
annotated source: receptor ligand activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-8848663

Axiom
annotated source: receptor ligand activity
annotated property: has_related_synonym
annotated target: receptor agonist activity
database_cross_reference: GOC:molecular_function_refactoring

anatomical structure formation involved in morphogenesis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: anatomical structure development
definition: The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
has_exact_synonym: formation of an anatomical structure involved in morphogenesis
has_obo_namespace: biological_process
id: GO:0048646
in_subset: goslim chembl
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.

Axiom
annotated source: anatomical structure formation involved in morphogenesis
annotated property: definition
annotated target: The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid
database_cross_reference: GOC:tb

Axiom
annotated source: anatomical structure formation involved in morphogenesis
annotated property: has_exact_synonym
annotated target: formation of an anatomical structure involved in morphogenesis
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

anatomical structure development
type: Class
subclass of: biological_process
definition: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/26424
has_exact_synonym: development of an anatomical structure
has_obo_namespace: biological_process
id: GO:0048856
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim plant ribbon

Axiom
annotated source: anatomical structure development
annotated property: definition
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
database_cross_reference: GO_REF:0000021

cell motility
type: Class
subclass of: biological_process
definition: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
term tracker item: https://github.com/geneontology/go-ontology/issues/19809
has_exact_synonym: cell locomotion
has_exact_synonym: movement of a cell
has_obo_namespace: biological_process
has_related_synonym: cell movement
id: GO:0048870
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim prokaryote

Axiom
annotated source: cell motility
annotated property: definition
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg

steroid sulfotransferase activity
type: Class
subclass of: sulfotransferase activity
definition: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
term tracker item: https://github.com/geneontology/go-ontology/issues/21412
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
has_broad_synonym: steroid alcohol sulfotransferase
database_cross_reference: EC:2.8.2.15
database_cross_reference: MetaCyc:STEROID-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:68460
database_cross_reference: Reactome:R-HSA-176517
database_cross_reference: Reactome:R-HSA-176521
database_cross_reference: Reactome:R-HSA-176631
has_exact_synonym: steroid sulphotransferase activity
has_obo_namespace: molecular_function
has_related_synonym: 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity
id: GO:0050294
in_subset: goslim chembl

Axiom
annotated source: steroid sulfotransferase activity
annotated property: definition
annotated target: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
database_cross_reference: MetaCyc:STEROID-SULFOTRANSFERASE-RXN
database_cross_reference: RHEA:68460

Axiom
annotated source: steroid sulfotransferase activity
annotated property: has_broad_synonym
annotated target: steroid alcohol sulfotransferase
database_cross_reference: EC:2.8.2.15

SULTs transfer (SO4)2- group to PREG
type: Axiom
annotated source: steroid sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176517

beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
type: Axiom
annotated source: steroid sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176521

dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
type: Axiom
annotated source: steroid sulfotransferase activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-176631

Axiom
annotated source: steroid sulfotransferase activity
annotated property: has_related_synonym
annotated target: 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity
database_cross_reference: EC:2.8.2.15

regulation of catalytic activity
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: regulates
  some values from: catalytic activity
definition: Any process that modulates the activity of an enzyme.
has_alternative_id: GO:0048552
has_exact_synonym: regulation of enzyme activity
has_narrow_synonym: regulation of metalloenzyme activity
has_obo_namespace: biological_process
id: GO:0050790
in_subset: gocheck obsoletion candidate
in_subset: goslim chembl

Axiom
annotated source: regulation of catalytic activity
annotated property: definition
annotated target: Any process that modulates the activity of an enzyme.
database_cross_reference: GOC:ai
database_cross_reference: GOC:ebc
database_cross_reference: GOC:vw

protein stabilization
type: Class
subclass of: biological_process
definition: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
has_exact_synonym: positive regulation of protein stability
has_exact_synonym: protein stabilisation
has_narrow_synonym: lysosomal protein stabilization
has_obo_namespace: biological_process
has_related_synonym: protein sequestering
has_related_synonym: protein stabilization activity
id: GO:0050821
in_subset: goslim chembl

Axiom
annotated source: protein stabilization
annotated property: definition
annotated target: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
database_cross_reference: GOC:ai

Axiom
annotated source: protein stabilization
annotated property: has_exact_synonym
annotated target: protein stabilisation
database_cross_reference: GOC:ah

extracellular matrix binding
type: Class
subclass of: molecular_function
definition: Binding to a component of the extracellular matrix.
has_exact_synonym: extracellular matrix constituent binding
has_obo_namespace: molecular_function
has_related_synonym: adhesive extracellular matrix constituent
id: GO:0050840
in_subset: goslim chembl
in_subset: goslim pir

Axiom
annotated source: extracellular matrix binding
annotated property: definition
annotated target: Binding to a component of the extracellular matrix.
database_cross_reference: GOC:ai

nervous system process
type: Class
subclass of: biological_process
definition: An organ system process carried out by any of the organs or tissues of the neurological system.
term tracker item: https://github.com/geneontology/go-ontology/issues/13824
has_exact_synonym: neurological system process
has_exact_synonym: neurophysiological process
has_obo_namespace: biological_process
has_related_synonym: pan-neural process
id: GO:0050877
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated source: nervous system process
annotated property: definition
annotated target: An organ system process carried out by any of the organs or tissues of the neurological system.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mtg_cardio

unfolded protein binding
type: Class
subclass of: protein binding
definition: Binding to an unfolded protein.
term tracker item: https://github.com/geneontology/go-ontology/issues/21436
has_broad_synonym: chaperone activity
database_cross_reference: Reactome:R-HSA-9683772
database_cross_reference: Reactome:R-HSA-9694337
has_obo_namespace: molecular_function
id: GO:0051082
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim yeast

Axiom
annotated source: unfolded protein binding
annotated property: definition
annotated target: Binding to an unfolded protein.
database_cross_reference: GOC:ai

Trimmed spike protein binds to calnexin
type: Axiom
annotated source: unfolded protein binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9683772

Trimmed spike protein binds to calnexin
type: Axiom
annotated source: unfolded protein binding
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-9694337

phosphoprotein binding
type: Class
subclass of: protein binding
definition: Binding to a phosphorylated protein.
has_exact_synonym: phosphorylated protein binding
has_obo_namespace: molecular_function
id: GO:0051219
in_subset: goslim chembl

Axiom
annotated source: phosphoprotein binding
annotated property: definition
annotated target: Binding to a phosphorylated protein.
database_cross_reference: GOC:ai

chromosome organization
type: Class
subclass of: biological_process
definition: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
term tracker item: https://github.com/geneontology/go-ontology/issues/22811
term tracker item: https://github.com/geneontology/go-ontology/issues/4585
has_alternative_id: GO:0006323
has_alternative_id: GO:0007001
has_alternative_id: GO:0051277
has_exact_synonym: DNA condensation
has_exact_synonym: chromosome organisation
has_narrow_synonym: DNA packaging
has_obo_namespace: biological_process
has_related_synonym: chromosome organization and biogenesis
has_related_synonym: maintenance of genome integrity
has_related_synonym: nuclear genome maintenance
id: GO:0051276
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir

Axiom
annotated source: chromosome organization
annotated property: definition
annotated target: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah

Axiom
annotated source: chromosome organization
annotated property: has_related_synonym
annotated target: chromosome organization and biogenesis
database_cross_reference: GOC:mah

NAD binding
type: Class
subclass of: adenyl nucleotide binding
definition: Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
has_alternative_id: GO:0051288
has_exact_synonym: nicotinamide adenine dinucleotide binding
has_obo_namespace: molecular_function
has_related_synonym: NAD or NADH binding
has_related_synonym: NAD+ or NADH binding
id: GO:0051287
in_subset: goslim chembl

Axiom
annotated source: NAD binding
annotated property: definition
annotated target: Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
database_cross_reference: GOC:ai

Axiom
annotated source: NAD binding
annotated property: has_related_synonym
annotated target: NAD or NADH binding
database_cross_reference: GOC:mah

cell division
type: Class
subclass of: biological_process
definition: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
database_cross_reference: Wikipedia:Cell_division
has_obo_namespace: biological_process
id: GO:0051301
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim pir
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.

Axiom
annotated source: cell division
annotated property: definition
annotated target: The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
database_cross_reference: GOC:di
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:pr

BH domain binding
type: Class
subclass of: protein domain specific binding
definition: Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.
has_exact_synonym: Bcl-2 homology domain binding
has_obo_namespace: molecular_function
id: GO:0051400
in_subset: goslim chembl

Axiom
annotated source: BH domain binding
annotated property: definition
annotated target: Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains.
database_cross_reference: PMID:11048732
database_cross_reference: PMID:12133724
database_cross_reference: PMID:9020082
database_cross_reference: PMID:9704409

peptide hormone receptor binding
type: Class
subclass of: signaling receptor binding
definition: Binding to a receptor for a peptide hormone.
has_exact_synonym: polypeptide hormone receptor binding
has_obo_namespace: molecular_function
id: GO:0051428
in_subset: goslim chembl

Axiom
annotated source: peptide hormone receptor binding
annotated property: definition
annotated target: Binding to a receptor for a peptide hormone.
database_cross_reference: GOC:ai

BH3 domain binding
type: Class
subclass of: BH domain binding
definition: Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
has_obo_namespace: molecular_function
id: GO:0051434
in_subset: goslim chembl

Axiom
annotated source: BH3 domain binding
annotated property: definition
annotated target: Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
database_cross_reference: PMID:11048732
database_cross_reference: PMID:12133724
database_cross_reference: PMID:9020082
database_cross_reference: PMID:9704409
database_cross_reference: Prosite:PS01259

protein maturation
type: Class
subclass of: metabolic process
subclass of: Restriction
  on property: part of
  some values from: biosynthetic process
definition: Any process leading to the attainment of the full functional capacity of a protein.
has_obo_namespace: biological_process
id: GO:0051604
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim yeast

Axiom
annotated source: protein maturation
annotated property: definition
annotated target: Any process leading to the attainment of the full functional capacity of a protein.
database_cross_reference: GOC:ai

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
definition: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP.
term tracker item: https://github.com/geneontology/go-ontology/issues/28070
created by: ai
creation date: 2010-07-06T12:10:01Z
database_cross_reference: MetaCyc:PHOSNACMURPENTATRANS-RXN
database_cross_reference: RHEA:28386
has_obo_namespace: molecular_function
id: GO:0051992
in_subset: goslim chembl
comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13.
broad match: http://purl.uniprot.org/enzyme/2.7.8.13

Axiom
annotated source: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
annotated property: definition
annotated target: Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP.
database_cross_reference: RHEA:28386

L-leucine-2-oxoglutarate transaminase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/28070
term tracker item: https://github.com/geneontology/go-ontology/issues/28176
database_cross_reference: KEGG_REACTION:R01090
database_cross_reference: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN
database_cross_reference: RHEA:18321
has_exact_synonym: L-leucine aminotransferase activity
has_obo_namespace: molecular_function
id: GO:0052654
in_subset: goslim chembl

Axiom
annotated source: L-leucine-2-oxoglutarate transaminase activity
annotated property: definition
annotated target: Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
database_cross_reference: RHEA:18321

L-valine-2-oxoglutarate transaminase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/28070
database_cross_reference: KEGG_REACTION:R01214
database_cross_reference: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN
database_cross_reference: RHEA:24813
has_exact_synonym: L-valine aminotransferase activity
has_obo_namespace: molecular_function
id: GO:0052655
in_subset: goslim chembl

Axiom
annotated source: L-valine-2-oxoglutarate transaminase activity
annotated property: definition
annotated target: Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.
database_cross_reference: RHEA:24813

L-isoleucine-2-oxoglutarate transaminase activity
type: Class
subclass of: transferase activity
definition: Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
term tracker item: https://github.com/geneontology/go-ontology/issues/28070
database_cross_reference: KEGG_REACTION:R02199
database_cross_reference: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN
database_cross_reference: RHEA:24801
has_exact_synonym: L-isoleucine aminotransferase activity
has_obo_namespace: molecular_function
id: GO:0052656
in_subset: goslim chembl

Axiom
annotated source: L-isoleucine-2-oxoglutarate transaminase activity
annotated property: definition
annotated target: Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.
database_cross_reference: RHEA:24801

virion membrane
type: Class
subclass of: virion component
definition: The lipid bilayer surrounding a virion.
has_obo_namespace: cellular_component
id: GO:0055036
in_subset: goslim chembl

Axiom
annotated source: virion membrane
annotated property: definition
annotated target: The lipid bilayer surrounding a virion.
database_cross_reference: GOC:jid
database_cross_reference: GOC:rph
database_cross_reference: PMID:213106

transmembrane transport
type: Class
subclass of: transport
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
created by: tb
creation date: 2015-10-21T13:22:47Z
has_alternative_id: GO:0090662
database_cross_reference: Reactome:R-HSA-382556
database_cross_reference: Reactome:R-HSA-425407
database_cross_reference: Reactome:R-HSA-5223345
has_exact_synonym: membrane transport
has_narrow_synonym: ATP hydrolysis coupled transmembrane transport
has_obo_namespace: biological_process
id: GO:0055085
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

Axiom
annotated source: transmembrane transport
annotated property: definition
annotated target: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jid

ABC-family proteins mediated transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-382556

SLC-mediated transmembrane transport
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-425407

Miscellaneous transport and binding events
type: Axiom
annotated source: transmembrane transport
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-5223345

membrane organization
type: Class
subclass of: biological_process
definition: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
created by: jl
creation date: 2010-02-08T02:43:11Z
has_alternative_id: GO:0016044
has_alternative_id: GO:0044802
database_cross_reference: Reactome:R-HSA-199991
has_exact_synonym: cellular membrane organisation
has_exact_synonym: cellular membrane organization
has_exact_synonym: membrane organisation
has_obo_namespace: biological_process
has_related_synonym: membrane organization and biogenesis
has_related_synonym: single-organism membrane organization
id: GO:0061024
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: membrane organization
annotated property: definition
annotated target: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb

Membrane Trafficking
type: Axiom
annotated source: membrane organization
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-199991

Axiom
annotated source: membrane organization
annotated property: has_exact_synonym
annotated target: membrane organisation
database_cross_reference: GOC:mah

Axiom
annotated source: membrane organization
annotated property: has_related_synonym
annotated target: membrane organization and biogenesis
database_cross_reference: GOC:mah

protein-containing complex assembly
type: Class
subclass of: cellular component assembly
definition: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
term tracker item: https://github.com/geneontology/go-ontology/issues/22580
has_alternative_id: GO:0006461
has_alternative_id: GO:0034622
has_alternative_id: GO:0043623
has_exact_synonym: cellular protein complex assembly
has_obo_namespace: biological_process
has_related_synonym: cellular macromolecule complex assembly
has_related_synonym: cellular protein-containing complex assembly
has_related_synonym: chaperone activity
has_related_synonym: macromolecular complex assembly
has_related_synonym: macromolecule complex assembly
has_related_synonym: protein complex assembly
has_related_synonym: protein complex formation
id: GO:0065003
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: protein-containing complex assembly
annotated property: definition
annotated target: The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
database_cross_reference: GOC:jl

N-acylphosphatidylethanolamine-specific phospholipase D activity
type: Class
subclass of: D-type glycerophospholipase activity
definition: Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
term tracker item: https://github.com/geneontology/go-ontology/issues/27559
term tracker item: https://github.com/geneontology/go-ontology/issues/30193
database_cross_reference: EC:3.1.4.54
database_cross_reference: MetaCyc:RXN-12116
database_cross_reference: RHEA:33159
database_cross_reference: Reactome:R-HSA-2466831
has_exact_synonym: N-acyl-phosphatidylethanolamine-specific phospholipase D activity
has_exact_synonym: NAPE-specific phospholipase D activity
has_obo_namespace: molecular_function
id: GO:0070290
in_subset: goslim chembl

Axiom
annotated source: N-acylphosphatidylethanolamine-specific phospholipase D activity
annotated property: definition
annotated target: Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
database_cross_reference: PMID:14634025
database_cross_reference: PMID:15878693
database_cross_reference: RHEA:33159

A2PE hydrolyses to A2E
type: Axiom
annotated source: N-acylphosphatidylethanolamine-specific phospholipase D activity
annotated property: database_cross_reference
annotated target: Reactome:R-HSA-2466831

thyroid hormone binding
type: Class
subclass of: hormone binding
definition: Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
has_narrow_synonym: thyroxine binding
has_narrow_synonym: triiodothyronine binding
has_obo_namespace: molecular_function
id: GO:0070324
in_subset: goslim chembl

Axiom
annotated source: thyroid hormone binding
annotated property: definition
annotated target: Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
database_cross_reference: GOC:rph

Axiom
annotated source: thyroid hormone binding
annotated property: has_narrow_synonym
annotated target: thyroxine binding
database_cross_reference: GOC:mah

Axiom
annotated source: thyroid hormone binding
annotated property: has_narrow_synonym
annotated target: triiodothyronine binding
database_cross_reference: GOC:mah

proteasome binding
type: Class
subclass of: protein-containing complex binding
definition: Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
created by: mah
creation date: 2009-05-01T04:38:58Z
has_obo_namespace: molecular_function
id: GO:0070628
in_subset: goslim chembl

Axiom
annotated source: proteasome binding
annotated property: definition
annotated target: Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
database_cross_reference: GOC:mah

TIR domain binding
type: Class
subclass of: protein domain specific binding
definition: Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.
created by: mah
creation date: 2009-10-02T01:17:29Z
has_exact_synonym: Toll-Interleukin receptor domain binding
has_obo_namespace: molecular_function
id: GO:0070976
in_subset: goslim chembl

Axiom
annotated source: TIR domain binding
annotated property: definition
annotated target: Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components.
database_cross_reference: GOC:mah
database_cross_reference: InterPro:IPR000157

Axiom
annotated source: TIR domain binding
annotated property: has_exact_synonym
annotated target: Toll-Interleukin receptor domain binding
database_cross_reference: InterPro:IPR000157

oxidative demethylation
type: Class
subclass of: metabolic process
definition: The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
created by: mah
creation date: 2009-10-29T03:33:25Z
has_obo_namespace: biological_process
id: GO:0070989
in_subset: goslim chembl

Axiom
annotated source: oxidative demethylation
annotated property: definition
annotated target: The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
database_cross_reference: GOC:rl

cellular response to xenobiotic stimulus
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
term tracker item: https://github.com/geneontology/go-ontology/issues/19460
created by: mah
creation date: 2009-12-18T11:38:48Z
has_alternative_id: GO:0035690
has_obo_namespace: biological_process
has_related_synonym: cellular response to drug
id: GO:0071466
in_subset: goslim chembl

Axiom
annotated source: cellular response to xenobiotic stimulus
annotated property: definition
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
database_cross_reference: GOC:krc
database_cross_reference: GOC:mah

cell wall organization or biogenesis
type: Class
subclass of: biological_process
definition: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
created by: mah
creation date: 2010-01-13T03:19:38Z
has_alternative_id: GO:0070882
has_exact_synonym: cell wall organisation or biogenesis
has_exact_synonym: cell wall organization or biogenesis at cellular level
has_exact_synonym: cellular cell wall organisation or biogenesis
has_exact_synonym: cellular cell wall organization or biogenesis
has_obo_namespace: biological_process
id: GO:0071554
in_subset: goslim chembl
in_subset: goslim euk cellular processes ribbon
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote
in_subset: goslim prokaryote ribbon
in_subset: goslim yeast

Axiom
annotated source: cell wall organization or biogenesis
annotated property: definition
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall.
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organisation or biogenesis
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cell wall organization or biogenesis at cellular level
database_cross_reference: GOC:mah

Axiom
annotated source: cell wall organization or biogenesis
annotated property: has_exact_synonym
annotated target: cellular cell wall organisation or biogenesis
database_cross_reference: GOC:mah

nitrogen cycle metabolic process
type: Class
subclass of: metabolic process
definition: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
created by: mah
creation date: 2010-09-30T05:21:03Z
database_cross_reference: Wikipedia:Nitrogen_cycle
has_obo_namespace: biological_process
id: GO:0071941
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim prokaryote

Axiom
annotated source: nitrogen cycle metabolic process
annotated property: definition
annotated target: A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization.
database_cross_reference: GOC:mah
database_cross_reference: PMID:16675690
database_cross_reference: Wikipedia:Nitrogen_cycle

mitotic nuclear division
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part of
  some values from: mitotic cell cycle
definition: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
term tracker item: https://github.com/geneontology/go-ontology/issues/19910
created by: pg
creation date: 2017-03-23T14:44:23Z
has_exact_synonym: mitosis
has_obo_namespace: biological_process
id: GO:0140014
in_subset: goslim chembl
in_subset: goslim generic

Axiom
annotated source: mitotic nuclear division
annotated property: definition
annotated target: A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
database_cross_reference: ISBN:0198547684

ATP-dependent activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: has part
  some values from: ribonucleoside triphosphate phosphatase activity
definition: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
term tracker item: https://github.com/geneontology/go-ontology/issues/21612
term tracker item: https://github.com/geneontology/go-ontology/issues/22371
created by: pg
creation date: 2021-06-15T07:35:06Z
has_exact_synonym: ATP hydrolysis-dependent activity
has_exact_synonym: ATPase activity
has_exact_synonym: ATPase activity, coupled
has_exact_synonym: ATPase-dependent activity
has_obo_namespace: molecular_function
id: GO:0140657
in_subset: gocheck do not annotate
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim prokaryote
in_subset: goslim yeast
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.

Axiom
annotated source: ATP-dependent activity
annotated property: definition
annotated target: A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.
database_cross_reference: PMID:24878343
database_cross_reference: PMID:25750732
database_cross_reference: PMID:32933017
database_cross_reference: PMID:33818025
database_cross_reference: PMID:33873056
database_cross_reference: PMID:33988324