{ "graphs" : [ { "id" : "http://purl.obolibrary.org/obo/go/subsets/goslim_chembl.owl", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", "val" : "2026-04-06" } ], "version" : "http://purl.obolibrary.org/obo/go/releases/2026-04-06/subsets/goslim_chembl.owl" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/GO_0000149", "lbl" : "SNARE binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.", "xrefs" : [ "PMID:12642621" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "SNAP receptor binding" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-210426" }, { "val" : "Reactome:R-HSA-210430" }, { "val" : "Reactome:R-HSA-265166" }, { "val" : "Reactome:R-HSA-372505" }, { "val" : "Reactome:R-HSA-372529" }, { "val" : "Reactome:R-HSA-374899" }, { "val" : "Reactome:R-HSA-374922" }, { "val" : "Reactome:R-HSA-376357" }, { "val" : "Reactome:R-HSA-376364" }, { "val" : "Reactome:R-HSA-376369" }, { "val" : "Reactome:R-HSA-380574" }, { "val" : "Reactome:R-HSA-380869" }, { "val" : "Reactome:R-HSA-380901" }, { "val" : "Reactome:R-HSA-380905" }, { "val" : "Reactome:R-HSA-888589" }, { "val" : "Reactome:R-HSA-9023173" }, { "val" : "Reactome:R-HSA-917744" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000166", "lbl" : "nucleotide binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.", "xrefs" : [ "GOC:mah", "ISBN:0198547684" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000215", "lbl" : "tRNA 2'-phosphotransferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. 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In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.", "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] }, "comments" : [ "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "mitosis" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-69278" }, { "val" : "Wikipedia:Mitosis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0007067" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000902", "lbl" : "cell morphogenesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "The developmental process in which the size or shape of a cell is generated and organized.", "xrefs" : [ "GOC:clt", "GOC:curators", "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular morphogenesis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0007148" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0045790" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0045791" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001515", "lbl" : "opioid peptide activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.", "xrefs" : [ "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001517", "lbl" : "N-acetylglucosamine 6-O-sulfotransferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.", "xrefs" : [ "GOC:ai", "GOC:hjd" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "N-acetylglucosamine 6-O-sulphotransferase activity" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-2046222" }, { "val" : "Reactome:R-HSA-3656269" }, { "val" : "Reactome:R-HSA-6786012" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001540", "lbl" : "amyloid-beta binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an amyloid-beta peptide/protein.", "xrefs" : [ "GOC:hjd" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "beta-amyloid binding" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20109" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001618", "lbl" : "virus receptor activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Combining with a virus component and mediating entry of the virus into the cell.", "xrefs" : [ "GOC:bf", "GOC:dph", "PMID:7621403", "UniProtKB-KW:KW-1183" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "viral receptor activity" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-9922480" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001968", "lbl" : "fibronectin binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.", "xrefs" : [ "GOC:hjd" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002376", "lbl" : "immune system process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.", "xrefs" : [ "GOC:add", "GO_REF:0000022" ] }, "comments" : [ "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "xrefs" : [ { "val" : "Wikipedia:Immune_system" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003013", "lbl" : "circulatory system process", "type" : "CLASS", "meta" : { "definition" : { "val" : "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.", "xrefs" : [ "GOC:mtg_cardio" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic" ], "xrefs" : [ { "val" : "Wikipedia:Circulatory_system" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003674", "lbl" : "molecular_function", "type" : "CLASS", "meta" : { "definition" : { "val" : "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", "xrefs" : [ "GOC:pdt" ] }, "comments" : [ "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "molecular function" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0005554" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003676", "lbl" : "nucleic acid binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a nucleic acid.", "xrefs" : [ "GOC:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "base pairing" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0000496" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003677", "lbl" : "DNA binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).", "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:tb", "GOC:vw" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "plasmid binding" }, { "pred" : "hasRelatedSynonym", "val" : "microtubule/chromatin interaction" }, { "pred" : "hasRelatedSynonym", "val" : "structure specific DNA binding" }, { "pred" : "hasRelatedSynonym", "val" : "structure-specific DNA binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043566" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003682", "lbl" : "chromatin binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.", "xrefs" : [ "GOC:jl", "ISBN:0198506732", "PMID:20404130" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "lamin/chromatin binding" }, { "pred" : "hasNarrowSynonym", "val" : "microtubule/chromatin interaction" }, { "pred" : "hasNarrowSynonym", "val" : "nuclear membrane vesicle binding to chromatin" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003700", "lbl" : "DNA-binding transcription factor activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.", "xrefs" : [ "GOC:txnOH-2018" ] }, "comments" : [ "Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "nucleic acid binding transcription factor activity" }, { "pred" : "hasBroadSynonym", "val" : "transcription factor activity" }, { "pred" : "hasExactSynonym", "val" : "DNA binding transcription factor activity" }, { "pred" : "hasExactSynonym", "val" : "gene-specific transcription factor activity" }, { "pred" : "hasExactSynonym", "val" : "sequence-specific DNA binding transcription factor activity" }, { "pred" : "hasNarrowSynonym", "val" : "bacterial-type DNA binding transcription factor activity" }, { "pred" : "hasNarrowSynonym", "val" : "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" }, { "pred" : "hasNarrowSynonym", "val" : "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" }, { "pred" : "hasNarrowSynonym", "val" : "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" }, { "pred" : "hasNarrowSynonym", "val" : "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" }, { "pred" : "hasNarrowSynonym", "val" : "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" }, { "pred" : 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receptor ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005138", "lbl" : "interleukin-6 receptor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an interleukin-6 receptor.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "IL-6" }, { "pred" : "hasNarrowSynonym", "val" : "interleukin-6 receptor ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005153", "lbl" : "interleukin-8 receptor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an interleukin-8 receptor.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "IL-8" }, { "pred" : "hasNarrowSynonym", "val" : "interleukin-8 receptor ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005154", "lbl" : "epidermal growth factor receptor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an epidermal growth factor receptor.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "EGF receptor binding" }, { "pred" : "hasExactSynonym", "val" : "EGFR binding" }, { "pred" : "hasExactSynonym", "val" : "TGF-alpha receptor binding" }, { "pred" : "hasExactSynonym", "val" : "TGFalpha receptor binding" }, { "pred" : "hasExactSynonym", "val" : "transforming growth factor alpha receptor binding" }, { "pred" : "hasNarrowSynonym", "val" : "EGF" }, { "pred" : "hasNarrowSynonym", "val" : "EGF receptor ligand" }, { "pred" : "hasNarrowSynonym", "val" : "epidermal growth factor" }, { "pred" : "hasNarrowSynonym", "val" : "epidermal growth factor receptor ligand" }, { "pred" : "hasNarrowSynonym", "val" : "transforming growth factor alpha" }, { "pred" : "hasNarrowSynonym", "val" : "transforming growth factor alpha receptor ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0008185" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005164", "lbl" : "tumor necrosis factor receptor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a tumor necrosis factor receptor.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "TNF receptor binding" }, { "pred" : "hasNarrowSynonym", "val" : "tumor necrosis factor" }, { "pred" : "hasNarrowSynonym", "val" : "tumor necrosis factor receptor ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005178", "lbl" : "integrin binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an integrin.", "xrefs" : [ "GOC:ceb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "integrin ligand" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005179", "lbl" : "hormone activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.", "xrefs" : [ "GOC:dph", "GOC:mah", "ISBN:0198506732" ] }, "comments" : [ "Also consider annotating to 'receptor agonist activity ; GO:0048018'." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cAMP generating peptide activity" }, { "pred" : "hasNarrowSynonym", "val" : "glycopeptide hormone" }, { "pred" : "hasNarrowSynonym", "val" : "lipopeptide hormone" }, { "pred" : "hasNarrowSynonym", "val" : "peptide hormone" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005184", "lbl" : "neuropeptide hormone activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.", "xrefs" : [ "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neurohormone" } ], "xrefs" : [ { "val" : "Wikipedia:Neurohormone" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005198", "lbl" : "structural molecule activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "The action of a molecule that contributes to the structural integrity of a complex.", "xrefs" : [ "GOC:mah", "GOC:vw" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24130" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005215", "lbl" : "transporter activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.", "xrefs" : [ "GOC:ai", "GOC:dgf" ] }, "comments" : [ "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "carrier" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27621" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0005478" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005484", "lbl" : "SNAP receptor activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.", "xrefs" : [ "GOC:mah", "PMID:14570579" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "SNARE" }, { "pred" : "hasNarrowSynonym", "val" : "Q-SNARE activity" }, { "pred" : "hasNarrowSynonym", "val" : "R-SNARE activity" }, { "pred" : "hasNarrowSynonym", "val" : "SNAP-25" }, { "pred" : "hasNarrowSynonym", "val" : "t-SNARE activity" }, { "pred" : "hasNarrowSynonym", "val" : "v-SNARE activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31564" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0005485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0005486" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005515", "lbl" : "protein binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a protein.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "protein amino acid binding" }, { "pred" : "hasNarrowSynonym", "val" : "glycoprotein binding" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-9866132" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0001948" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0045308" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005516", "lbl" : "calmodulin binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.", "xrefs" : [ "GOC:krc" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "xrefs" : [ { "val" : "Reactome:R-HSA-202110" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005520", "lbl" : "insulin-like growth factor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.", "xrefs" : [ "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "IGF binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005537", "lbl" : "D-mannose binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.", "xrefs" : [ "GOC:jl", "ISBN:0192800981" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "mannose binding" }, { "pred" : "hasRelatedSynonym", "val" : "mannose binding lectin" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-947991" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005539", "lbl" : "glycosaminoglycan binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.", "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005575", "lbl" : "cellular_component", "type" : "CLASS", "meta" : { "definition" : { "val" : "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).", "xrefs" : [ "GOC:pdt" ] }, "comments" : [ "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell or subcellular entity" }, { "pred" : "hasExactSynonym", "val" : "cellular component" }, { "pred" : "hasRelatedSynonym", "val" : "subcellular entity", "xrefs" : [ "NIF_Subcellular:nlx_subcell_100315" ] } ], "xrefs" : [ { "val" : "NIF_Subcellular:sao1337158144" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17729" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0008372" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005576", "lbl" : "extracellular region", "type" : "CLASS", "meta" : { "definition" : { "val" : "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.", "xrefs" : [ "GOC:curators" ] }, "comments" : [ "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "extracellular" } ], "xrefs" : [ { "val" : "Wikipedia:Extracellular" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005618", "lbl" : "cell wall", "type" : "CLASS", "meta" : { "definition" : { "val" : "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.", "xrefs" : [ "GOC:giardia", "ISBN:0198547684", "PMID:15134259", "Wikipedia:Microbial_cyst" ] }, "comments" : [ "Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "xrefs" : [ { "val" : "Wikipedia:Cell_wall" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21669" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005622", "lbl" : "intracellular anatomical structure", "type" : "CLASS", "meta" : { "definition" : { "val" : "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.", "xrefs" : [ "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "internal to cell" }, { "pred" : "hasExactSynonym", "val" : "intracellular" }, { "pred" : "hasExactSynonym", "val" : "protoplasm" }, { "pred" : "hasRelatedSynonym", "val" : "nucleocytoplasm", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "protoplast", "xrefs" : [ "GOC:mah" ] } ], "xrefs" : [ { "val" : "Wikipedia:Intracellular" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17776" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005634", "lbl" : "nucleus", "type" : "CLASS", "meta" : { "definition" : { "val" : "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. 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