{ "graphs" : [ { "id" : "http://purl.obolibrary.org/obo/go/subsets/gocheck_do_not_annotate.owl", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", "val" : "2026-04-20" } ], "version" : "http://purl.obolibrary.org/obo/go/releases/2026-04-20/subsets/gocheck_do_not_annotate.owl" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/GO_0000075", "lbl" : "cell cycle checkpoint signaling", "type" : "CLASS", "meta" : { "definition" : { "val" : "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell cycle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in G2/M transition checkpoint" }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in cell cycle checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "G1/S checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "G1/S transition checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "G2/M checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "G2/M transition checkpoint" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-69620", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Cell Cycle Checkpoints" } ] } }, { "val" : "Wikipedia:Cell_cycle_checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20935" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0031576" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071779" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072395" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072404" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072407" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000080", "lbl" : "mitotic G1 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "G1 phase of mitotic cell cycle" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-69236", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "G1 Phase" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000084", "lbl" : "mitotic S phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "S phase of mitotic cell cycle" }, { "pred" : "hasExactSynonym", "val" : "S-phase of mitotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000085", "lbl" : "mitotic G2 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "G2 phase of mitotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000087", "lbl" : "mitotic M phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "M phase of mitotic cell cycle" }, { "pred" : "hasExactSynonym", "val" : "M-phase of mitotic cell cycle" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-68886", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "M Phase" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000088", "lbl" : "mitotic prophase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000089", "lbl" : "mitotic metaphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000090", "lbl" : "mitotic anaphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000091", "lbl" : "mitotic anaphase A", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000092", "lbl" : "mitotic anaphase B", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000093", "lbl" : "mitotic telophase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000236", "lbl" : "mitotic prometaphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Reactome:R-HSA-68877", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Mitotic Prometaphase" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24374" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000237", "lbl" : "leptotene", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Leptotene" }, { "val" : "Wikipedia:Meiosis#Leptotene" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000238", "lbl" : "zygotene", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Meiosis#Zygotene" }, { "val" : "Wikipedia:Zygotene" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000239", "lbl" : "pachytene", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Meiosis#Pachytene" }, { "val" : "Wikipedia:Pachytene" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000240", "lbl" : "diplotene", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Diplotene" }, { "val" : "Wikipedia:Meiosis#Diplotene" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000241", "lbl" : "diakinesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Diakinesis" }, { "val" : "Wikipedia:Meiosis#Diakinesis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000279", "lbl" : "M phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "M-phase" } ], "xrefs" : [ { "val" : "Wikipedia:M_phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000910", "lbl" : "cytokinesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell cycle cytokinesis" }, { "pred" : "hasExactSynonym", "val" : "cytokinesis involved in cell cycle", "xrefs" : [ "GOC:dph", "GOC:tb" ] } ], "xrefs" : [ { "val" : "Wikipedia:Cytokinesis" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0007104" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0016288" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0033205" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001101", "lbl" : "response to acid chemical", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.", "xrefs" : [ "GOC:curators", "GOC:rn" ] }, "comments" : [ "This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "response to acid" }, { "pred" : "hasRelatedSynonym", "val" : "response to acid anion" }, { "pred" : "hasRelatedSynonym", "val" : "response to oxoanion" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001539", "lbl" : "cilium or flagellum-dependent cell motility", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.", "xrefs" : [ "GOC:cilia", "GOC:hjd", "GOC:krc" ] }, "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "ciliary/flagellar motility" }, { "pred" : "hasRelatedSynonym", "val" : "ciliary or bacterial-type flagellar motility" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001816", "lbl" : "cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cytokine biosynthetic process" }, { "pred" : "hasNarrowSynonym", "val" : "cytokine metabolic process" }, { "pred" : "hasNarrowSynonym", "val" : "cytokine secretion" }, { "pred" : "hasNarrowSynonym", "val" : "interferon production", "xrefs" : [ "GOC:add", "GOC:mah" ] }, { "pred" : "hasNarrowSynonym", "val" : "interferon secretion", "xrefs" : [ "GOC:add", "GOC:mah" ] }, { "pred" : "hasNarrowSynonym", "val" : "interleukin production", "xrefs" : [ "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ] }, { "pred" : "hasNarrowSynonym", "val" : "interleukin secretion", "xrefs" : [ "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/19116" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0042032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0042089" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0042107" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0050663" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002367", "lbl" : "cytokine production involved in immune response", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "cytokine biosynthetic process involved in immune response" }, { "pred" : "hasRelatedSynonym", "val" : "cytokine production during immune response", "xrefs" : [ "GOC:dph" ] }, { "pred" : "hasRelatedSynonym", "val" : "cytokine secretion during immune response", "xrefs" : [ "GOC:dph" ] }, { "pred" : "hasRelatedSynonym", "val" : "cytokine secretion involved in immune response" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0002374" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0002375" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002368", "lbl" : "B cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a B cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "B lymphocyte cytokine production" }, { "pred" : "hasExactSynonym", "val" : "B-cell cytokine production" }, { "pred" : "hasExactSynonym", "val" : "B-lymphocyte cytokine production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002369", "lbl" : "T cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a T cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "T lymphocyte cytokine production" }, { "pred" : "hasExactSynonym", "val" : "T-cell cytokine production" }, { "pred" : "hasExactSynonym", "val" : "T-lymphocyte cytokine production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002370", "lbl" : "natural killer cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a natural killer cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "NK cell cytokine production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002371", "lbl" : "dendritic cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a dendritic cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002372", "lbl" : "myeloid dendritic cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a myeloid dendritic cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002373", "lbl" : "plasmacytoid dendritic cell cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a plasmacytoid dendritic cell.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002377", "lbl" : "immunoglobulin production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "antibody production" }, { "pred" : "hasNarrowSynonym", "val" : "immunoglobulin biosynthetic process" }, { "pred" : "hasNarrowSynonym", "val" : "immunoglobulin secretion" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0002378" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0048305" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002381", "lbl" : "immunoglobulin production involved in immunoglobulin-mediated immune response", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:9185563" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "immunoglobulin production involved in immunoglobulin mediated immune response" }, { "pred" : "hasNarrowSynonym", "val" : "immunoglobulin biosynthetic process involved in immune response" }, { "pred" : "hasNarrowSynonym", "val" : "immunoglobulin secretion involved in immune response" }, { "pred" : "hasRelatedSynonym", "val" : "antibody production during immune response" }, { "pred" : "hasRelatedSynonym", "val" : "antibody secretion during immune response" }, { "pred" : "hasRelatedSynonym", "val" : "immunoglobulin production during immune response", "xrefs" : [ "GOC:dph" ] }, { "pred" : "hasRelatedSynonym", "val" : "immunoglobulin production involved in immune response", "xrefs" : [ "GOC:dph" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0002379" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0002380" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002426", "lbl" : "immunoglobulin production in mucosal tissue", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis and release of immunoglobulin in the mucosal tissue.", "xrefs" : [ "GOC:jal" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "antibody production in mucosal tissue" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002440", "lbl" : "production of molecular mediator of immune response", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "production of cellular mediator of immune response" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002534", "lbl" : "cytokine production involved in inflammatory response", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "cytokine production involved in acute inflammatory response" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002775", "lbl" : "antimicrobial peptide production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.", "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002778", "lbl" : "antibacterial peptide production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002781", "lbl" : "antifungal peptide production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002831", "lbl" : "regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002832", "lbl" : "negative regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "downregulation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of response to biotic stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002833", "lbl" : "positive regulation of response to biotic stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of response to biotic stimulus" }, { "pred" : "hasExactSynonym", "val" : "upregulation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "activation of response to biotic stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of response to biotic stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0004448", "lbl" : "isocitrate dehydrogenase [NAD(P)+] activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "isocitrate dehydrogenase activity" }, { "pred" : "hasExactSynonym", "val" : "isocitric acid dehydrogenase activity" }, { "pred" : "hasExactSynonym", "val" : "isocitric dehydrogenase activity" }, { "pred" : "hasExactSynonym", "val" : "oxalosuccinate carboxylase activity" }, { "pred" : "hasExactSynonym", "val" : "oxalosuccinate decarboxylase activity" }, { "pred" : "hasExactSynonym", "val" : "oxalosuccinic decarboxylase activity" }, { "pred" : "hasRelatedSynonym", "val" : "IDH activity" }, { "pred" : "hasRelatedSynonym", "val" : "IDP activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/23235" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005215", "lbl" : "transporter activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.", "xrefs" : [ "GOC:ai", "GOC:dgf" ] }, "comments" : [ "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "carrier" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27621" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0005478" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005368", "lbl" : "taurine transmembrane transporter activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005618", "lbl" : "cell wall", "type" : "CLASS", "meta" : { "definition" : { "val" : "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.", "xrefs" : [ "GOC:giardia", "ISBN:0198547684", "PMID:15134259", "Wikipedia:Microbial_cyst" ] }, "comments" : [ "Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "xrefs" : [ { "val" : "Wikipedia:Cell_wall" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21669" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005622", "lbl" : "intracellular anatomical structure", "type" : "CLASS", "meta" : { "definition" : { "val" : "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.", "xrefs" : [ "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "internal to cell" }, { "pred" : "hasExactSynonym", "val" : "intracellular" }, { "pred" : "hasExactSynonym", "val" : "protoplasm" }, { "pred" : "hasRelatedSynonym", "val" : "nucleocytoplasm", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "protoplast", "xrefs" : [ "GOC:mah" ] } ], "xrefs" : [ { "val" : "Wikipedia:Intracellular" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17776" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006066", "lbl" : "alcohol metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.", "xrefs" : [ "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "alcohol metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006090", "lbl" : "pyruvate metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "pyruvate metabolism" }, { "pred" : "hasRelatedSynonym", "val" : "pyruvate dehydrogenase bypass" } ], "xrefs" : [ { "val" : "Wikipedia:Pyruvic_acid" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29541" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31634" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0006087" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006113", "lbl" : "fermentation", "type" : "CLASS", "meta" : { "definition" : { "val" : "The metabolic process that uses oxidation-reduction reactions of organic compounds and substrate-level phosphorylation for the generation of adenosine triphosphate (ATP), without consuming oxygen and is independent of electron transport chains.", "xrefs" : [ "PMID:25617754", "PMID:38821505" ] }, "comments" : [ "PMID:38821505 mentions exceptions regarding organic compounds and electron transport chain. Fermentation sub-processes exclude glycolysis to prevent redundancy with the glycolytic pathway." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "xrefs" : [ { "val" : "MetaCyc:Fermentation" }, { "val" : "Wikipedia:Fermentation_(biochemistry)" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28523" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29511" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006139", "lbl" : "nucleobase-containing compound metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" }, { "pred" : "hasExactSynonym", "val" : "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" }, { "pred" : "hasExactSynonym", "val" : "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" }, { "pred" : "hasRelatedSynonym", "val" : "nucleobase, nucleoside and nucleotide metabolic process" }, { "pred" : "hasRelatedSynonym", "val" : "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "xrefs" : [ "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31498" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0055134" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006810", "lbl" : "transport", "type" : "CLASS", "meta" : { "definition" : { "val" : "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.", "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:jl", "GOC:mah" ] }, "comments" : [ "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "single-organism transport" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-382551", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Transport of small molecules" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20292" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-12-13T16:25:32Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0015457" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0015460" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044765" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006996", "lbl" : "organelle organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "organelle organisation" }, { "pred" : "hasExactSynonym", "val" : "single organism organelle organization", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "organelle organization and biogenesis", "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "single-organism organelle organization" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-1852241", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Organelle biogenesis and maintenance" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27189" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-19T15:25:51Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:1902589" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007049", "lbl" : "cell cycle", "type" : "CLASS", "meta" : { "definition" : { "val" : "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.", "xrefs" : [ "GOC:curators", "GOC:mtg_cell_cycle" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell-division cycle" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-1640170", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Cell Cycle" } ] } }, { "val" : "Wikipedia:Cell_cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007093", "lbl" : "mitotic cell cycle checkpoint signaling", "type" : "CLASS", "meta" : { "definition" : { "val" : "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "mitotic cell cycle checkpoint" }, { "pred" : "hasExactSynonym", "val" : "signal transduction involved in mitotic cell cycle checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "signal transduction involved in mitotic G2/M transition checkpoint" }, { "pred" : "hasNarrowSynonym", "val" : "signal transduction involved in mitotic cell cycle G1/S checkpoint" }, { "pred" : "hasRelatedSynonym", "val" : "mitotic checkpoint" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20935" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0031575" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071780" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072413" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072456" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0072474" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007128", "lbl" : "meiotic prophase I", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007132", "lbl" : "meiotic metaphase I", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25408" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007133", "lbl" : "meiotic anaphase I", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25408" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007134", "lbl" : "meiotic telophase I", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007136", "lbl" : "meiotic prophase II", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007137", "lbl" : "meiotic metaphase II", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25408" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007138", "lbl" : "meiotic anaphase II", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25408" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007139", "lbl" : "meiotic telophase II", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007275", "lbl" : "multicellular organism development", "type" : "CLASS", "meta" : { "definition" : { "val" : "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:isa_complete", "GOC:tb" ] }, "comments" : [ "Note that this term was 'developmental process'." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21234" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007549", "lbl" : "sex-chromosome dosage compensation", "type" : "CLASS", "meta" : { "definition" : { "val" : "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.", "xrefs" : [ "GOC:ems", "PMID:11498577", "PMID:30049999", "PMID:35306885" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "dosage compensation" }, { "pred" : "hasExactSynonym", "val" : "sex chromosome dosage compensation" } ], "xrefs" : [ { "val" : "Wikipedia:Sex-chromosome_dosage_compensation" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25961" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26961" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007588", "lbl" : "excretion", "type" : "CLASS", "meta" : { "definition" : { "val" : "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.", "xrefs" : [ "ISBN:0192801023" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "xrefs" : [ { "val" : "Wikipedia:Excretion" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/22368" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007610", "lbl" : "behavior", "type" : "CLASS", "meta" : { "definition" : { "val" : "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.", "xrefs" : [ "GOC:ems", "GOC:jl", "ISBN:0395448956", "PMID:20160973" ] }, "comments" : [ "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "behavioral response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "behaviour" }, { "pred" : "hasExactSynonym", "val" : "behavioural response to stimulus" }, { "pred" : "hasRelatedSynonym", "val" : "single-organism behavior" } ], "xrefs" : [ { "val" : "Wikipedia:Behavior" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-09-20T14:06:08Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0023032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044708" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044709" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008134", "lbl" : "transcription factor binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to a transcription factor, a protein required to initiate or regulate transcription.", "xrefs" : [ "ISBN:0198506732" ] }, "comments" : [ "Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "TF binding" }, { "pred" : "hasRelatedSynonym", "val" : "transcription regulator binding" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/19354" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008152", "lbl" : "metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.", "xrefs" : [ "GOC:curators", "ISBN:0198547684" ] }, "comments" : [ "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "metabolism" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-1430728", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Metabolism" } ] } }, { "val" : "Wikipedia:Metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28932" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-17T15:46:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044236" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044710" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008219", "lbl" : "cell death", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).", "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ] }, "comments" : [ "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "accidental cell death" }, { "pred" : "hasRelatedSynonym", "val" : "necrosis" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24680" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008452", "lbl" : "RNA ligase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another.", "xrefs" : [ "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27418" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008937", "lbl" : "ferredoxin-[NAD(P)H] reductase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "ferredoxin reductase activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21649" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29598" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009056", "lbl" : "catabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. 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It should be possible to make a more specific annotation to one of the children of this term." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell physiology" }, { "pred" : "hasExactSynonym", "val" : "cellular physiological process" }, { "pred" : "hasNarrowSynonym", "val" : "cell growth and/or maintenance" }, { "pred" : "hasRelatedSynonym", "val" : "single-organism cellular process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-12-11T16:56:55Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0008151" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044763" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0050875" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010556", "lbl" : "regulation of macromolecule biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31483" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010557", "lbl" : "positive regulation of macromolecule biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31483" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010558", "lbl" : "negative regulation of macromolecule biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/30771" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010604", "lbl" : "positive regulation of macromolecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010605", "lbl" : "negative regulation of macromolecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010638", "lbl" : "positive regulation of organelle organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "positive regulation of organelle organisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "positive regulation of organelle organization and biogenesis", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010639", "lbl" : "negative regulation of organelle organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "negative regulation of organelle organisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "negative regulation of organelle organization and biogenesis", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010835", "lbl" : "regulation of protein ADP-ribosylation", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "regulation of protein amino acid ADP-ribosylation", "xrefs" : [ "GOC:bf" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010836", "lbl" : "negative regulation of protein ADP-ribosylation", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.", "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "negative regulation of protein amino acid ADP-ribosylation", "xrefs" : [ "GOC:bf" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010934", "lbl" : "macrophage cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:rl", "GOC:tb" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014076", "lbl" : "response to fluoxetine", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor.", "xrefs" : [ "GOC:ef", "GOC:pr" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to SSRI" }, { "pred" : "hasRelatedSynonym", "val" : "response to selective serotonin reuptake inhibitor" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016043", "lbl" : "cellular component organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.", "xrefs" : [ "GOC:ai", "GOC:jl", "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cell organisation" }, { "pred" : "hasExactSynonym", "val" : "cellular component organisation at cellular level", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "cellular component organisation in other organism", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "cellular component organization at cellular level" }, { "pred" : "hasExactSynonym", "val" : "cellular component organization in other organism" }, { "pred" : "hasRelatedSynonym", "val" : "cell organization and biogenesis", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044235" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071842" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016049", "lbl" : "cell growth", "type" : "CLASS", "meta" : { "definition" : { "val" : "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular growth" }, { "pred" : "hasExactSynonym", "val" : "growth of cell" }, { "pred" : "hasRelatedSynonym", "val" : "cell expansion" }, { "pred" : "hasRelatedSynonym", "val" : "metabolic process resulting in cell growth" }, { "pred" : "hasRelatedSynonym", "val" : "metabolism resulting in cell growth" }, { "pred" : "hasRelatedSynonym", "val" : "non-developmental cell growth", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "non-developmental growth of a unicellular organism", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0048591" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016631", "lbl" : "enoyl-[acyl-carrier-protein] reductase [NAD(P)H] activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+.", "xrefs" : [ "GOC:rb" ] }, "comments" : [ "This term should not be used for direct annotation; please use of the children that specifies the cofactor of the reaction (NAD+ or NADP+): enoyl-[acyl-carrier-protein] reductase (NADH) activity ; GO:0004318 or enoyl-[acyl-carrier-protein] reductase (NADPH) activity ; GO:0141148." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "enoyl-[acyl-carrier-protein] reductase activity" }, { "pred" : "hasExactSynonym", "val" : "enoyl-ACP reductase activity" }, { "pred" : "hasExactSynonym", "val" : "enoyl-[acyl-carrier protein] reductase activity" }, { "pred" : "hasExactSynonym", "val" : "enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H)" }, { "pred" : "hasExactSynonym", "val" : "enoyl-acyl carrier protein reductase" } ], "xrefs" : [ { "val" : "Wikipedia:Enoyl-acyl_carrier_protein_reductase" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25307" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28526" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017186", "lbl" : "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase.", "xrefs" : [ "RESID:AA0031" ] }, "comments" : [ "See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; 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Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "host chloroplast component" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033655", "lbl" : "host cell cytoplasm part", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. 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Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "cytoplasm component" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034212", "lbl" : "protein N-acetyltransferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.", "xrefs" : [ "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "peptide N-acetyltransferase activity" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-3371554", "meta" : { "basicPropertyValues" : [ { "pred" : 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Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-03-17T02:39:11Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035944", "lbl" : "perforin production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-07-27T11:44:21Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036211", "lbl" : "protein modification process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).", "xrefs" : [ "GOC:bf", "GOC:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular protein modification process" }, { "pred" : "hasExactSynonym", "val" : "process resulting in protein modification" }, { "pred" : "hasExactSynonym", "val" : "protein modification", "xrefs" : [ "GOC:bf" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/23112" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-04-26T01:47:12Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0006464" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036262", "lbl" : "granulysin production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-06-18T02:11:15Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036270", "lbl" : "response to diuretic", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:26:24Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036271", "lbl" : "response to methylphenidate", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.", "xrefs" : [ "GOC:hp", "Wikipedia:Methylphenidate" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to MPD", "xrefs" : [ "CHEBI:6887" ] }, { "pred" : "hasExactSynonym", "val" : "response to MPH", "xrefs" : [ "CHEBI:6887" ] }, { "pred" : "hasExactSynonym", "val" : "response to ritalin", "xrefs" : [ "CHEBI:6887" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:30:57Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036272", "lbl" : "response to gemcitabine", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.", "xrefs" : [ "GOC:hp", "Wikipedia:Gemcitabine" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to 2',2'-difluorodeoxycytidine", "xrefs" : [ "CHEBI:175901" ] }, { "pred" : "hasExactSynonym", "val" : "response to 2'-deoxy-2',2'-difluorocytidine", "xrefs" : [ "CHEBI:175901" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:36:03Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036273", "lbl" : "response to statin", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "response to HMG-CoA reductase inhibitor", "xrefs" : [ "CHEBI:35664" ] }, { "pred" : "hasRelatedSynonym", "val" : "response to hydroxymethylglutaryl-CoA reductase inhibitor", "xrefs" : [ "CHEBI:35664" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T01:54:01Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036274", "lbl" : "response to lapatinib", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:02:26Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036275", "lbl" : "response to 5-fluorouracil", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to 5-fluoropyrimidine-2,4(1H,3H)-dione", "xrefs" : [ "CHEBI:46345" ] }, { "pred" : "hasExactSynonym", "val" : "response to fluorouracil", "xrefs" : [ "GOC:hp" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:08:23Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036276", "lbl" : "response to antidepressant", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:12:44Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036277", "lbl" : "response to anticonvulsant", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-09T02:40:12Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036287", "lbl" : "response to iloperidone", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-16T05:01:29Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036288", "lbl" : "response to ximelagatran", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-07-16T05:03:56Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036301", "lbl" : "macrophage colony-stimulating factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:BHF", "GOC:vk" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "M-CSF production", "xrefs" : [ "GOC:vk" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-08-07T14:07:13Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036392", "lbl" : "chemokine (C-C motif) ligand 20 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:jc" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "C-C motif chemokine 20 production" }, { "pred" : "hasExactSynonym", "val" : "CCL-20 production" }, { "pred" : "hasExactSynonym", "val" : "CCL20 production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-06-17T14:42:07Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0038183", "lbl" : "bile acid signaling pathway", "type" : "CLASS", "meta" : { "definition" : { "val" : "The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.", "xrefs" : [ "GOC:signaling", "PMID:12016314", "PMID:36409000" ] }, "comments" : [ "This term is not for direct annotation. Please use a more specific child: 'cell surface bile acid receptor signaling pathway' for GPCRs and 'intracellular bile acid receptor signaling pathway' for nuclear receptors." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26958" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bf" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-05-16T10:35:10Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040007", "lbl" : "growth", "type" : "CLASS", "meta" : { "definition" : { "val" : "The increase in size or mass of an entire organism, a part of an organism or a cell.", "xrefs" : [ "GOC:bf", "GOC:ma" ] }, "comments" : [ "See also the biological process term 'cell growth ; GO:0016049'." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "growth pattern" }, { "pred" : "hasRelatedSynonym", "val" : "non-developmental growth", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0048590" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042221", "lbl" : "response to chemical", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to chemical stimulus", "xrefs" : [ "GOC:dos" ] }, { "pred" : "hasExactSynonym", "val" : "response to chemical substance" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042637", "lbl" : "catagen", "type" : "CLASS", "meta" : { "definition" : { "val" : "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.", "xrefs" : [ "PMID:12535193" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "hair regression" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042638", "lbl" : "exogen", "type" : "CLASS", "meta" : { "definition" : { "val" : "The shedding phase of the hair cycle.", "xrefs" : [ "PMID:12230507" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "hair shedding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042639", "lbl" : "telogen", "type" : "CLASS", "meta" : { "definition" : { "val" : "The resting phase of hair cycle.", "xrefs" : [ "PMID:12230507" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "hair resting phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042640", "lbl" : "anagen", "type" : "CLASS", "meta" : { "definition" : { "val" : "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.", "xrefs" : [ "PMID:12230507" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "hair growth" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042696", "lbl" : "menarche", "type" : "CLASS", "meta" : { "definition" : { "val" : "The beginning of the menstrual cycle; the first menstrual cycle in an individual.", "xrefs" : [ "GOC:curators", "PMID:16311040" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Menarche" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042697", "lbl" : "menopause", "type" : "CLASS", "meta" : { "definition" : { "val" : "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50.", "xrefs" : [ "GOC:curators", "PMID:18495681" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Menopause" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042703", "lbl" : "menstruation", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.", "xrefs" : [ "GOC:curators", "PMID:8693059" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Menstruation" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042710", "lbl" : "biofilm formation", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.", "xrefs" : [ "GOC:di", "PMID:11932229" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "xrefs" : [ { "val" : "Reactome:R-HSA-9931953", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Biofilm formation" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17727" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042995", "lbl" : "cell projection", "type" : "CLASS", "meta" : { "definition" : { "val" : "A prolongation or process extending from a cell, e.g. a flagellum or axon.", "xrefs" : [ "GOC:jl", "PMID:16318917" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "cell process" }, { "pred" : "hasBroadSynonym", "val" : "cellular process" }, { "pred" : "hasExactSynonym", "val" : "cellular projection" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/23013" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043087", "lbl" : "regulation of GTPase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the rate of GTP hydrolysis by a GTPase.", "xrefs" : [ "GOC:jl", "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "regulation of ARF GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Cdc42 GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Rab GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Rac GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Ral GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Ran GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Rap GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Ras GTPase activity" }, { "pred" : "hasNarrowSynonym", "val" : "regulation of Rho GTPase activity" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032312" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032313" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032314" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032315" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032316" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032317" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032318" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0032319" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043088" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043167", "lbl" : "ion binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to an ion, a charged atoms or groups of atoms.", "xrefs" : [ "GOC:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "atom binding" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043170", "lbl" : "macromolecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "biopolymer metabolic process", "xrefs" : [ "GOC:mtg_chebi_dec09" ] }, { "pred" : "hasExactSynonym", "val" : "macromolecule metabolism" }, { "pred" : "hasExactSynonym", "val" : "organismal macromolecule metabolism" }, { "pred" : "hasNarrowSynonym", "val" : "multicellular organismal macromolecule metabolic process" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0034960" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043283" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0044259" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043227", "lbl" : "membrane-bounded organelle", "type" : "CLASS", "meta" : { "definition" : { "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "membrane-enclosed organelle" } ], "xrefs" : [ { "val" : "NIF_Subcellular:sao414196390" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28153" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043228", "lbl" : "membraneless organelle", "type" : "CLASS", "meta" : { "definition" : { "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_mouse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "membrane-less organelle" }, { "pred" : "hasExactSynonym", "val" : "non-membrane-bounded organelle" }, { "pred" : "hasExactSynonym", "val" : "non-membrane-enclosed organelle" }, { "pred" : "hasRelatedSynonym", "val" : "biological condensate" } ], "xrefs" : [ { "val" : "NIF_Subcellular:sao1456184038" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21881" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28153" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29106" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043229", "lbl" : "intracellular organelle", "type" : "CLASS", "meta" : { "definition" : { "val" : "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28153" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043231", "lbl" : "intracellular membrane-bounded organelle", "type" : "CLASS", "meta" : { "definition" : { "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "intracellular membrane-enclosed organelle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043232", "lbl" : "intracellular membraneless organelle", "type" : "CLASS", "meta" : { "definition" : { "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "intracellular non-membrane-bounded organelle" }, { "pred" : "hasExactSynonym", "val" : "intracellular non-membrane-enclosed organelle" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29106" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043388", "lbl" : "positive regulation of DNA binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).", "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of DNA binding" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of DNA binding" }, { "pred" : "hasExactSynonym", "val" : "upregulation of DNA binding" }, { "pred" : "hasNarrowSynonym", "val" : "activation of DNA binding" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of DNA binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043392", "lbl" : "negative regulation of DNA binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).", "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of DNA binding" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of DNA binding" }, { "pred" : "hasExactSynonym", "val" : "downregulation of DNA binding" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of DNA binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043393", "lbl" : "regulation of protein binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of protein binding.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043711", "lbl" : "pilus organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "pilus organisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "pilus organization and biogenesis", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043954", "lbl" : "cellular component maintenance", "type" : "CLASS", "meta" : { "definition" : { "val" : "The organization process that preserves a cellular component in a stable functional or structural state.", "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular component maintenance at cellular level" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071956" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044085", "lbl" : "cellular component biogenesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.", "xrefs" : [ "GOC:jl", "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular component biogenesis at cellular level" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27194" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071843" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044087", "lbl" : "regulation of cellular component biogenesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.", "xrefs" : [ "GOC:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044092", "lbl" : "negative regulation of molecular function", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", "xrefs" : [ "GO:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-04-21T04:07:27Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044094", "lbl" : "host cell nuclear part", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction.", "xrefs" : [ "GOC:ecd" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-04-22T01:59:14Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044217", "lbl" : "other organism part", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any constituent part of a secondary organism with which the first organism is interacting.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-11-12T01:18:21Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044238", "lbl" : "primary metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "primary metabolism" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-71291", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Metabolism of amino acids and derivatives" } ] } }, { "val" : "Wikipedia:Primary_metabolite" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044281", "lbl" : "small molecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.", "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] }, "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "small molecule metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : 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"https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-26T12:06:10Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044283", "lbl" : "small molecule biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.", "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] }, "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "small molecule biosynthesis" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-26T12:06:49Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044419", "lbl" : "biological process involved in interspecies interaction between organisms", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process evolved to enable an interaction with an organism of a different species.", "xrefs" : [ "GOC:cc" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "interaction with another species" }, { "pred" : "hasExactSynonym", "val" : "interspecies interaction" }, { "pred" : "hasExactSynonym", "val" : "interspecies interaction between organisms" }, { "pred" : "hasExactSynonym", "val" : "interspecies interaction with other organisms" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-9824443", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Parasitic Infection Pathways" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20191" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044467", "lbl" : "glial cell-derived neurotrophic factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons.", "xrefs" : [ "GOC:yaf", "PMID:17505307" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "GDNF production" }, { "pred" : "hasNarrowSynonym", "val" : "glial cell-derived neurotrophic factor secretion" }, { "pred" : "hasRelatedSynonym", "val" : "glial cell line-derived neurotrophic factor production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-01-17T04:26:05Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044703", "lbl" : "multi-organism reproductive process", "type" : "CLASS", "meta" : { "definition" : { "val" : "A biological process that directly contributes to the process of producing new individuals, involving another organism.", "xrefs" : [ "GOC:jl" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-09-19T15:56:30Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044807", "lbl" : "macrophage migration inhibitory factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "MIF production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-09-11T12:04:09Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044808", "lbl" : "oncostatin M production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "OSM production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-09-11T12:18:00Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044809", "lbl" : "chemokine (C-C motif) ligand 17 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CCL17 production" }, { "pred" : "hasExactSynonym", "val" : "TARC production" }, { "pred" : "hasExactSynonym", "val" : "thymus and activation regulated chemokine production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-09-11T12:21:31Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044838", "lbl" : "cell quiescence", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized resting state that cells enter in response to cues from the cell's environment. 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To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "quiescence", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "cellular quiescence", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "G0 phase", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "cell cycle quiescence", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-02-26T16:15:51Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044844", "lbl" : "meiotic interphase II", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge.", "xrefs" : [ "GOC:jl", "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-03-26T16:52:27Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044848", "lbl" : "biological phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A distinct period or stage in a biological process or cycle.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-07-16T13:12:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044851", "lbl" : "hair cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.", "xrefs" : [ "GOC:jl" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-07-16T14:22:09Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045239", "lbl" : "tricarboxylic acid cycle heteromeric enzyme complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any of the heteromeric enzymes that act in the TCA cycle.", "xrefs" : [ "GOC:mah" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "TCA cycle enzyme complex" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045934", "lbl" : "negative regulation of nucleobase-containing compound metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" }, { "pred" : "hasExactSynonym", "val" : "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" }, { "pred" : "hasExactSynonym", "val" : "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" }, { "pred" : "hasRelatedSynonym", "val" : "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process", "xrefs" : [ "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31498" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046164", "lbl" : "alcohol catabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "alcohol breakdown" }, { "pred" : "hasExactSynonym", "val" : "alcohol catabolism" }, { "pred" : "hasExactSynonym", "val" : "alcohol degradation" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046165", "lbl" : "alcohol biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "alcohol anabolism" }, { "pred" : "hasExactSynonym", "val" : "alcohol biosynthesis" }, { "pred" : "hasExactSynonym", "val" : "alcohol formation" }, { "pred" : "hasExactSynonym", "val" : "alcohol synthesis" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046624", "lbl" : "sphingolipid intramembrane carrier activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).", "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "sphingolipid intramembrane transporter activity" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-9695890", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "SPNS2,MFSD2B transport S1P from cytosol to extracellular region" } ] } }, { "val" : "Reactome:R-HSA-9843721", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "ABCC1,ABCG2 transport C18-S1P to extracellular region" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31121" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31454" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046907", "lbl" : "intracellular transport", "type" : "CLASS", "meta" : { "definition" : { "val" : "The directed movement of substances within a cell.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "single organism intracellular transport", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "single-organism intracellular transport" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-18T14:04:50Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:1902582" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048518", "lbl" : "positive regulation of biological process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", "xrefs" : [ "GOC:jid" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "positive regulation of physiological process" }, { "pred" : "hasExactSynonym", "val" : "up regulation of biological process" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of biological process" }, { "pred" : "hasExactSynonym", "val" : "upregulation of biological process" }, { "pred" : "hasNarrowSynonym", "val" : "activation of biological process" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of biological process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043119" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048519", "lbl" : "negative regulation of biological process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", "xrefs" : [ "GOC:jid" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of biological process" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of biological process" }, { "pred" : "hasExactSynonym", "val" : "downregulation of biological process" }, { "pred" : "hasExactSynonym", "val" : "negative regulation of physiological process" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of biological process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043118" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048522", "lbl" : "positive regulation of cellular process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", "xrefs" : [ "GOC:jid" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "positive regulation of cellular physiological process" }, { "pred" : "hasExactSynonym", "val" : "up regulation of cellular process" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of cellular process" }, { "pred" : "hasExactSynonym", "val" : "upregulation of cellular process" }, { "pred" : "hasNarrowSynonym", "val" : "activation of cellular process" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of cellular process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0051242" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048523", "lbl" : "negative regulation of cellular process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. 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Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", "xrefs" : [ "GOC:jid" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048584", "lbl" : "positive regulation of response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates, maintains or increases the rate of a response to a stimulus. 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Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "upregulation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "activation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048585", "lbl" : "negative regulation of response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. 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Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of response to stimulus" }, { "pred" : "hasExactSynonym", "val" : "downregulation of response to stimulus" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048588", "lbl" : "developmental cell growth", "type" : "CLASS", "meta" : { "definition" : { "val" : "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.", "xrefs" : [ "GOC:curators", "GOC:isa_complete" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "developmental growth of a unicellular organism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048609", "lbl" : "multicellular organismal reproductive process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. 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For example, cell communication occurs among more than one cell, but occurs at the cellular level.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "regulation of cellular physiological process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0051244" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050896", "lbl" : "response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.", "xrefs" : [ "GOC:ai", "GOC:bf" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "physiological response to stimulus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0051869" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051098", "lbl" : "regulation of binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051099", "lbl" : "positive regulation of binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "up regulation of binding" }, { "pred" : "hasExactSynonym", "val" : "up-regulation of binding" }, { "pred" : "hasExactSynonym", "val" : "upregulation of binding" }, { "pred" : "hasNarrowSynonym", "val" : "activation of binding" }, { "pred" : "hasNarrowSynonym", "val" : "stimulation of binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051100", "lbl" : "negative regulation of binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of binding" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of binding" }, { "pred" : "hasExactSynonym", "val" : "downregulation of binding" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of binding" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051101", "lbl" : "regulation of DNA binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).", "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051128", "lbl" : "regulation of cellular component organization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "regulation of cellular component organisation" }, { "pred" : "hasRelatedSynonym", "val" : "regulation of cell organisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "regulation of cell organization", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasRelatedSynonym", "val" : "regulation of cellular component organization and biogenesis", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051179", "lbl" : "localization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.", "xrefs" : [ "GOC:ai", "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "establishment and maintenance of localization" }, { "pred" : "hasExactSynonym", "val" : "establishment and maintenance of position" }, { "pred" : "hasExactSynonym", "val" : "localisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasNarrowSynonym", "val" : "establishment and maintenance of cellular component location" }, { "pred" : "hasNarrowSynonym", "val" : "establishment and maintenance of substance location" }, { "pred" : "hasNarrowSynonym", "val" : "establishment and maintenance of substrate location" }, { "pred" : "hasRelatedSynonym", "val" : "single organism localization", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "single-organism localization" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27052" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-18T13:51:04Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:1902578" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051234", "lbl" : "establishment of localization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.", "xrefs" : [ "GOC:ai", "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "establishment of localisation", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24200" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051253", "lbl" : "negative regulation of RNA metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of RNA metabolic process" }, { "pred" : "hasExactSynonym", "val" : "down-regulation of RNA metabolic process" }, { "pred" : "hasExactSynonym", "val" : "downregulation of RNA metabolic process" }, { "pred" : "hasExactSynonym", "val" : "negative regulation of RNA metabolism" }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of RNA metabolic process" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/30771" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051318", "lbl" : "G1 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:G1_phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051319", "lbl" : "G2 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:G2_phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051320", "lbl" : "S phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following G1, during which DNA synthesis takes place.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "S-phase" } ], "xrefs" : [ { "val" : "Wikipedia:S_phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051322", "lbl" : "anaphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Anaphase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051323", "lbl" : "metaphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Metaphase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051324", "lbl" : "prophase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Prophase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051325", "lbl" : "interphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "resting phase" }, { "pred" : "hasExactSynonym", "val" : "karyostasis" } ], "xrefs" : [ { "val" : "Wikipedia:Interphase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051326", "lbl" : "telophase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Wikipedia:Telophase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051327", "lbl" : "meiotic M phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "M phase of meiotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051328", "lbl" : "meiotic interphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "interphase of meiotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051329", "lbl" : "mitotic interphase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "interphase of mitotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051330", "lbl" : "meiotic G1 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "G1 phase of meiotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051331", "lbl" : "meiotic G2 phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "G2 phase of meiotic cell cycle" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051332", "lbl" : "meiotic S phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.", "xrefs" : [ "GOC:mtg_cell_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "S phase of meiotic cell cycle" }, { "pred" : "hasExactSynonym", "val" : "S-phase of meiotic cell cycle" }, { "pred" : "hasExactSynonym", "val" : "premeiotic S-phase" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051640", "lbl" : "organelle localization", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process in which an organelle is transported to, and/or maintained in, a specific location.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "establishment and maintenance of organelle localization" }, { "pred" : "hasExactSynonym", "val" : "organelle localisation", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/19809" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051641", "lbl" : "cellular localization", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.", "xrefs" : [ "GOC:tb", "GOC:vw" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular localisation", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "establishment and maintenance of cellular localization" }, { "pred" : "hasExactSynonym", "val" : "establishment and maintenance of localization in cell or cell membrane" }, { "pred" : "hasExactSynonym", "val" : "single organism cellular localization", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasNarrowSynonym", "val" : "intracellular localization" }, { "pred" : "hasNarrowSynonym", "val" : "localization within cell" }, { "pred" : "hasRelatedSynonym", "val" : "single-organism cellular localization" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27189" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "jl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2013-12-18T14:04:32Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:1902580" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051703", "lbl" : "biological process involved in intraspecies interaction between organisms", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process in which an organism has an effect on an organism of the same species.", "xrefs" : [ "GOC:ai" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "intraspecies interaction between organisms" }, { "pred" : "hasExactSynonym", "val" : "intraspecies interaction with other organisms" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20191" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051716", "lbl" : "cellular response to stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.", "xrefs" : [ "GOC:bf", "GOC:jl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Reactome:R-HSA-8953897", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Cellular responses to stimuli" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060089", "lbl" : "molecular transducer activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A compound molecular function in which an effector function is controlled by one or more regulatory components.", "xrefs" : [ "GOC:dos", "GOC:pdt" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060206", "lbl" : "estrous cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur.", "xrefs" : [ "GOC:dph" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060207", "lbl" : "diestrus", "type" : "CLASS", "meta" : { "definition" : { "val" : "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum.", "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060208", "lbl" : "proestrus", "type" : "CLASS", "meta" : { "definition" : { "val" : "The estrous cycle phase in which there is heightened follicular activity.", "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060209", "lbl" : "estrus", "type" : "CLASS", "meta" : { "definition" : { "val" : "The estrous cycle phase in which a female is sexually receptive.", "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "oestrus" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060210", "lbl" : "metestrus", "type" : "CLASS", "meta" : { "definition" : { "val" : "The estrous cycle phase in which there is subsiding follicular function.", "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060255", "lbl" : "regulation of macromolecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31032" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061082", "lbl" : "myeloid leukocyte cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that contributes to cytokine production by a myeloid cell.", "xrefs" : [ "GOC:dph" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-13T11:29:42Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061919", "lbl" : "process utilizing autophagic mechanism", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway.", "xrefs" : [ "PMID:21997368", "PMID:22966490", "PMID:28596378" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2017-07-13T19:42:14Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062012", "lbl" : "regulation of small molecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the rate, frequency or extent of a small molecule metabolic process.", "xrefs" : [ "GOC:vw" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "regulation of small molecule metabolism" } ], "xrefs" : [ { "val" : "Reactome:R-HSA-9861718", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Regulation of pyruvate metabolism" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2018-03-19T14:11:54Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062013", "lbl" : "positive regulation of small molecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.", "xrefs" : [ "GOC:vw" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "positive regulation of small molecule metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2018-03-19T14:25:10Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062014", "lbl" : "negative regulation of small molecule metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.", "xrefs" : [ "GOC:vw" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "negative regulation of small molecule metabolism" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31485" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2018-03-19T14:27:23Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062039", "lbl" : "biofilm matrix", "type" : "CLASS", "meta" : { "definition" : { "val" : "A type of extracellular matrix that surrounds the cells within a microbial biofilm. 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Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "xrefs" : [ { "val" : "Reactome:R-HSA-9860931", "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2000/01/rdf-schema#label", "val" : "Response of endothelial cells to shear stress" } ] } } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-18T02:25:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071496", "lbl" : "cellular response to external stimulus", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-12-18T02:36:52Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071605", "lbl" : "monocyte chemotactic protein-1 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CCL2 production", "xrefs" : [ "GOC:add", "GOC:rv" ] }, { "pred" : "hasExactSynonym", "val" : "MCP-1 production", "xrefs" : [ "GOC:add", "GOC:rv" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T04:09:53Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071606", "lbl" : "chemokine (C-C motif) ligand 4 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "macrophage inflammatory protein production", "xrefs" : [ "GOC:add", "GOC:rv" ] }, { "pred" : "hasExactSynonym", "val" : "CCL4 production", "xrefs" : [ "GOC:add", "GOC:rv" ] }, { "pred" : "hasExactSynonym", "val" : "MIP-1b production", "xrefs" : [ "GOC:add", "GOC:rv" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T04:16:42Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071607", "lbl" : "macrophage inflammatory protein-1 gamma production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", 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"biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071609", "lbl" : "chemokine (C-C motif) ligand 5 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CCL5 production", "xrefs" : [ "GOC:add", "GOC:rv" ] }, { "pred" : "hasExactSynonym", "val" : "RANTES production", "xrefs" : [ "GOC:bf" ] }, { "pred" : "hasExactSynonym", "val" : "Regulated upon Activation, Normal T-cell Expressed, and Secreted production", "xrefs" : [ "GOC:add", "GOC:rv" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : 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"basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T04:35:00Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071611", "lbl" : "granulocyte colony-stimulating factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CSF3 production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasExactSynonym", "val" : "G-CSF production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasExactSynonym", "val" : "colony stimulating factor 3 (granulocyte) production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasExactSynonym", "val" : "filgrastim production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasExactSynonym", "val" : "granulocyte colony stimulating factor production" }, { "pred" : "hasExactSynonym", "val" : "lenograstim production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasExactSynonym", "val" : "pluripoietin production", "xrefs" : [ "GOC:add" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T04:38:11Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071612", "lbl" : "IP-10 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of IP-10 due to biosynthesis 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secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add", "GOC:rv" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T04:47:15Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071706", "lbl" : "tumor necrosis factor superfamily cytokine production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:add" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "TNFSF cytokine production", "xrefs" : [ "GOC:add" ] }, { "pred" : "hasRelatedSynonym", "val" : "TNF superfamily production", "xrefs" : [ "GOC:rv" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-03-09T02:40:35Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071840", "lbl" : "cellular component organization or biogenesis", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.", "xrefs" : [ "GOC:mah" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular component organisation or biogenesis", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "cellular component organisation or biogenesis at cellular level", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "cellular component organization or biogenesis at cellular level" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27189" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-10T01:39:16Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0071841" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071924", "lbl" : "chemokine (C-C motif) ligand 22 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:mah", "PMID:18832724" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "C-C motif chemokine 22 production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "CCL-22 production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "CCL22 production", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-28T11:33:13Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071925", "lbl" : "thymic stromal lymphopoietin production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:mah", "PMID:17129180" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "TSLP production", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-09-28T11:38:55Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071954", "lbl" : "chemokine (C-C motif) ligand 11 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:mah", "PMID:9600955" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "eotaxin production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "C-C motif chemokine 11 production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "CCL-11 production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "CCL11 production", "xrefs" : [ "GOC:mah" ] }, { "pred" : "hasExactSynonym", "val" : "eotaxin-1 production", "xrefs" : [ "GOC:mah" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-10-08T12:10:34Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072001", "lbl" : "renal system development", "type" : "CLASS", "meta" : { "definition" : { "val" : "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. 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If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "vegetative growth of a single-celled organism" }, { "pred" : "hasNarrowSynonym", "val" : "stationary phase" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/18275" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-08-19T12:05:19Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0062178" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080090", "lbl" : "regulation of primary metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", "xrefs" : [ "PMID:19211694" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31498" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dhl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-04-22T04:30:52Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080134", "lbl" : "regulation of response to stress", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:dhl" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dhl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2009-05-06T04:51:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090231", "lbl" : "regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090232", "lbl" : "positive regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "spindle checkpoint activation", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090233", "lbl" : "negative regulation of spindle checkpoint", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "spindle checkpoint silencing", "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-01-20T10:29:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090269", "lbl" : "fibroblast growth factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:BHF" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-02-05T02:33:33Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090304", "lbl" : "nucleic acid metabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any cellular metabolic process involving nucleic acids.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26133" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27052" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-04-07T10:18:47Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090360", "lbl" : "platelet-derived growth factor production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:BHF" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "tb" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2010-07-12T10:32:27Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097087", "lbl" : "interleukin-17A production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv", "PMID:27901018" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "IL-17A production" }, { "pred" : "hasNarrowSynonym", "val" : "interleukin-17A biosynthetic process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bc" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-06-23T11:31:10Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0150154" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097088", "lbl" : "interleukin-17F production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv", "Wikipedia:Interleukin_17" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "IL-17F production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2011-06-23T11:32:59Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097366", "lbl" : "response to bronchodilator", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.", "xrefs" : [ "GOC:hp" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "response to bronchodilator agent" }, { "pred" : "hasRelatedSynonym", "val" : "response to broncholytic agent" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-08-01T16:13:31Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097388", "lbl" : "chemokine (C-C motif) ligand 19 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CCL19 production" }, { "pred" : "hasExactSynonym", "val" : "EBI1 ligand chemokine production" }, { "pred" : "hasExactSynonym", "val" : "ELC production" }, { "pred" : "hasExactSynonym", "val" : "MIP-3-beta production" }, { "pred" : "hasExactSynonym", "val" : "macrophage inflammatory protein-3-beta production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-23T07:54:10Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097389", "lbl" : "chemokine (C-C motif) ligand 21 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CCL21 production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-23T07:56:26Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097390", "lbl" : "chemokine (C-X-C motif) ligand 12 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CXCL12 production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-23T07:57:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097391", "lbl" : "chemokine (C-X-C motif) ligand 13 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CXCL13 production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-23T07:58:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097392", "lbl" : "chemokine (C-X-C motif) ligand 16 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:rv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "CXCL16 production" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-10-23T07:59:43Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097722", "lbl" : "sperm motility", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process involved in the controlled movement of a sperm cell.", "xrefs" : [ "GOC:cilia", "GOC:krc" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "sperm movement" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2016-09-01T12:00:45Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098590", "lbl" : "plasma membrane region", "type" : "CLASS", "meta" : { "definition" : { "val" : "A membrane that is a (regional) part of the plasma membrane.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "region of plasma membrane" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dos" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2014-03-06T11:55:32Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098751", "lbl" : "bone cell development", "type" : "CLASS", "meta" : { "definition" : { "val" : "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098762", "lbl" : "meiotic cell cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098763", "lbl" : "mitotic cell cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098764", "lbl" : "meiosis I cell cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098765", "lbl" : "meiosis II cell cycle phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division).", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098768", "lbl" : "meiotic prometaphase I", "type" : "CLASS", "meta" : { "definition" : { "val" : "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate.", "xrefs" : [ "PMID:16012859" ] }, "comments" : [ "This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24374" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098772", "lbl" : "molecular function regulator activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.", "xrefs" : [ "GOC:dos", "GOC:pt" ] }, "comments" : [ "This term should only be used in cases when the regulator directly interacts with the enzyme, but does not result in a covalent modification." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "molecular function regulator" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20854" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/20862" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/25165" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098791", "lbl" : "Golgi apparatus subcompartment", "type" : "CLASS", "meta" : { "definition" : { "val" : "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "Golgi subcompartment" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/30705" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098798", "lbl" : "mitochondrial protein-containing complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A protein complex that is part of a mitochondrion.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "mitochondrial protein complex" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098802", "lbl" : "plasma membrane signaling receptor complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.", "xrefs" : [ "GOC:dos" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099080", "lbl" : "supramolecular complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099134", "lbl" : "chimeric sorocarp development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development of a sorocarp formed by aggregation of cells with different genotypes.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099135", "lbl" : "chimeric colonial development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099136", "lbl" : "chimeric non-reproductive fruiting body development", "type" : "CLASS", "meta" : { "definition" : { "val" : "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.", "xrefs" : [ "PMID:18272966" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099522", "lbl" : "cytosolic region", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "region of cytosol" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31276" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099568", "lbl" : "cytoplasmic region", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31276" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099738", "lbl" : "cell cortex region", "type" : "CLASS", "meta" : { "definition" : { "val" : "The complete extent of cell cortex that underlies some some region of the plasma membrane.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "perimembrane region" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31276" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110100", "lbl" : "spindle pole body separation", "type" : "CLASS", "meta" : { "definition" : { "val" : "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble.", "xrefs" : [ "GOC:vw" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "kmv" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2018-03-06T15:09:28Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110165", "lbl" : "cellular anatomical structure", "type" : "CLASS", "meta" : { "definition" : { "val" : "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.", "xrefs" : [ "GOC:kmv" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular anatomical entity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/24200" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/26424" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/28978" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "kmv" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2019-08-12T18:01:37Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120562", "lbl" : "GlcNAc(2)-PP-Dol mannosyltransferase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the transfer of a mannosyl residue to GlcNAc(2)-PP-Dol bearing 0-8 mannoses during synthesis of the N-glycan precursor.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/30326" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "sjm" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2025-05-28T07:19:38Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140029", "lbl" : "exocytic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cellular processes that contribute to exocytosis.", "xrefs" : [ "Wikipedia:Exocytosis" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2017-05-15T13:20:45Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140110", "lbl" : "transcription regulator activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.", "xrefs" : [ "GOC:pg", "GOC:txnOH-2018", "Wikipedia:Transcription_factor" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/13588" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/23609" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2017-10-18T07:05:44Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140142", "lbl" : "nucleocytoplasmic carrier activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein.", "xrefs" : [ "GOC:pg" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "nucleocytoplasmic importin/exportin activity" }, { "pred" : "hasNarrowSynonym", "val" : "miRNA transporter activity" }, { "pred" : "hasNarrowSynonym", "val" : "pre-miRNA transporter activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/14336" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/17399" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2017-12-06T13:40:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0061717" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0090631" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140392", "lbl" : "extracellular protein-containing complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "extracellular protein complex" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/31673" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2020-09-09T05:12:38Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140513", "lbl" : "nuclear protein-containing complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.", "xrefs" : [ "GOC:pg" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "nuclear complex" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2020-09-09T05:12:38Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140657", "lbl" : "ATP-dependent activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient.", "xrefs" : [ "PMID:24878343", "PMID:25750732", "PMID:32933017", "PMID:33818025", "PMID:33873056", "PMID:33988324" ] }, "comments" : [ "Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "ATP hydrolysis-dependent activity" }, { "pred" : "hasExactSynonym", "val" : "ATPase activity" }, { "pred" : "hasExactSynonym", "val" : "ATPase activity, coupled" }, { "pred" : "hasExactSynonym", "val" : "ATPase-dependent activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21612" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/22371" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2021-06-15T07:35:06Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140699", "lbl" : "cyclic GMP-AMP synthase activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.", "xrefs" : [ "PMID:23258413" ] }, "comments" : [ "Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that describes the position of the phosphate group on the cGAMP molecule." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cyclic-GMP-AMP synthase activity" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21980" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2021-08-27T05:05:37Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140702", "lbl" : "cyclic GMP-AMP binding", "type" : "CLASS", "meta" : { "definition" : { "val" : "Binding to cyclic GMP-AMP (cGAMP) nucleotide.", "xrefs" : [ "PMID:23258412" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21980" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2021-08-27T05:39:31Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140730", "lbl" : "amphiregulin production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.", "xrefs" : [ "PMID:24463227" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "AREG production" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/21878" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2021-11-24T07:09:44Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140779", "lbl" : "XCL1 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of XCL1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "PMID:7973732" ] }, "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "lymphotactin production" } ], "xrefs" : [ { "val" : "Wikipedia:XCL1" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/23071" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2022-03-24T07:11:34Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0141187", "lbl" : "nucleic acid biosynthetic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The biosynthetic process resulting in the formation of a nucleic acid.", "xrefs" : [ "GOC:dph", "GOC:tb" ] }, "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27408" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27633" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2024-03-25T07:33:40Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0141188", "lbl" : "nucleic acid catabolic process", "type" : "CLASS", "meta" : { "definition" : { "val" : "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid.", "xrefs" : [ "GOC:curators" ] }, "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27408" }, { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27633" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pg" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2024-03-25T07:35:06Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150137", "lbl" : "interleukin-37 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:aruk", "PMID:30362558" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasNarrowSynonym", "val" : "interleukin-37 biosynthetic process" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bc" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2019-12-08T08:43:09Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150155", "lbl" : "interleukin-34 production", "type" : "CLASS", "meta" : { "definition" : { "val" : "The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", "xrefs" : [ "GOC:aruk", "PMID:26754294" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "bc" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2020-01-06T16:25:25Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0160266", "lbl" : "anestrus phase", "type" : "CLASS", "meta" : { "definition" : { "val" : "A biological phase of reproductive dormancy characterized by the temporary cessation of reproductive cyclicity, marked by the absence of ovarian follicular development, estrous behavior, and ovulation. This phase represents a period of sexual quiescence between estrous cycles or breeding seasons.", "xrefs" : [ "PMID:34635709", "WIKIPEDIA:Estrous_cycle" ] }, "comments" : [ "Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/30248" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "rynl" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2025-05-14T00:20:22Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0170055", "lbl" : "lipid transmembrane transporter activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "Enables the transfer of a lipid from one side of a membrane to the other.", "xrefs" : [ "GOC:curators" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/27252" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "ew" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2024-03-15T18:47:58Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0180051", "lbl" : "translation factor activity", "type" : "CLASS", "meta" : { "definition" : { "val" : "A molecular function required for translation of a mRNA into a protein functioning as part of initiation, elongation or termination of translation.", "xrefs" : [ "GOC:pg" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/29089" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "vw" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2025-01-20T11:51:48Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900068", "lbl" : "negative regulation of cellular response to alkaline pH", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity.", "xrefs" : [ "GOC:TermGenie", "GOC:dgf", "PMID:12509465", "PMID:17023428" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasBroadSynonym", "val" : "negative regulation of cellular response to alkalinity" }, { "pred" : "hasExactSynonym", "val" : "down regulation of cellular response to alkaline pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "down regulation of cellular response to basic pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "down-regulation of cellular response to alkaline pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "down-regulation of cellular response to basic pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "downregulation of cellular response to alkaline pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "downregulation of cellular response to basic pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "negative regulation of cellular response to basic pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of cellular response to alkaline pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of cellular response to alkalinity", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasNarrowSynonym", "val" : "inhibition of cellular response to basic pH", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "down regulation of cellular response to alkalinity", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "down-regulation of cellular response to alkalinity", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasRelatedSynonym", "val" : "downregulation of cellular response to alkalinity", "xrefs" : [ "GOC:TermGenie" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "pr" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", "val" : "2012-01-26T02:35:03Z" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900070", "lbl" : "negative regulation of cellular hyperosmotic salinity response", "type" : "CLASS", "meta" : { "definition" : { "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response.", "xrefs" : [ "GOC:TermGenie", "GOC:dgf", "PMID:16278455" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "down regulation of cellular response to hyperosmotic salt stress", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "down-regulation of cellular response to hyperosmotic salt stress", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "downregulation of cellular response to hyperosmotic salt stress", "xrefs" : [ "GOC:TermGenie" ] }, { "pred" : "hasExactSynonym", "val" : "negative regulation of cellular response to 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