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This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.", "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:pad", "PMID:10099709", "PMID:15217342" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neurotransmitter import into synaptic vesicle" }, { "pred" : "hasExactSynonym", "val" : "neurotransmitter uptake into synaptic vesicle", "xrefs" : [ "PMID:15217342" ] }, { "synonymType" : "http://purl.obolibrary.org/obo/go#syngo_official_label", "pred" : "hasExactSynonym", "val" : "synaptic vesicle neurotransmitter loading" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098793", "lbl" : "presynapse", "type" : "CLASS", "meta" : { "definition" : { "val" : "The part of a synapse that is part of the presynaptic cell.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "presynaptic terminal" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098794", "lbl" : "postsynapse", "type" : "CLASS", "meta" : { "definition" : { "val" : "The part of a synapse that is part of the post-synaptic cell.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098810", "lbl" : "neurotransmitter reuptake", "type" : "CLASS", "meta" : { "definition" : { "val" : "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098814", "lbl" : "spontaneous synaptic transmission", "type" : "CLASS", "meta" : { "definition" : { "val" : "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.", "xrefs" : [ "PMID:20200227" ] }, "comments" : [ "This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs)." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "basal synaptic transmission", "xrefs" : [ "PMID:16899074" ] } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098820", "lbl" : "trans-synaptic protein complex", "type" : "CLASS", "meta" : { "definition" : { "val" : "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.", "xrefs" : [ "PMID:20200227" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098830", "lbl" : "presynaptic endosome", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.", "xrefs" : [ "PMID:20200227", "PMID:25939282" ] }, "comments" : [ "As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098831", "lbl" : "presynaptic active zone cytoplasmic component", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cortex of presynaptic active zone" }, { "pred" : "hasExactSynonym", "val" : "presynaptic zone cortex" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098833", "lbl" : "presynaptic endocytic zone", "type" : "CLASS", "meta" : { "definition" : { "val" : "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. 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In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. 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This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098842", "lbl" : "postsynaptic early endosome", "type" : "CLASS", "meta" : { "definition" : { "val" : "An early endosome of the postsynapse. 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This region of membrane is associated with stable clathrin puncta.", "xrefs" : [ "PMID:17880892" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098845", "lbl" : "postsynaptic endosome", "type" : "CLASS", "meta" : { "definition" : { "val" : "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.", "xrefs" : [ "PMID:20820847" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098850", "lbl" : "extrinsic component of synaptic vesicle membrane", "type" : "CLASS", "meta" : { "definition" : { "val" : "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098871", "lbl" : "postsynaptic actin cytoskeleton", "type" : "CLASS", "meta" : { "definition" : { "val" : "The actin cytoskeleton that is part of a postsynapse.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098877", "lbl" : "neurotransmitter receptor transport to plasma membrane", "type" : "CLASS", "meta" : { "definition" : { "val" : "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098879", "lbl" : "structural constituent of postsynaptic specialization", "type" : "CLASS", "meta" : { "definition" : { "val" : "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098880", "lbl" : "maintenance of postsynaptic specialization structure", "type" : "CLASS", "meta" : { "definition" : { "val" : "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098882", "lbl" : "structural constituent of presynaptic active zone", "type" : "CLASS", "meta" : { "definition" : { "val" : "The action of a molecule that contributes to the structural integrity of a presynaptic active zone.", "xrefs" : [ "GOC:dos" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "synonyms" : [ { "synonymType" : "http://purl.obolibrary.org/obo/go#syngo_official_label", "pred" : "hasExactSynonym", "val" : "structural constituent of active zone" } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "molecular_function" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098883", "lbl" : "synapse pruning", "type" : "CLASS", "meta" : { "definition" : { "val" : "A cellular process that results in the controlled breakdown of synapse. 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"http://purl.obolibrary.org/obo/GO_0098890", "lbl" : "extrinsic component of postsynaptic membrane", "type" : "CLASS", "meta" : { "definition" : { "val" : "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", "xrefs" : [ "GOC:autophagy", "GOC:mf" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098891", "lbl" : "extrinsic component of presynaptic active zone membrane", "type" : "CLASS", "meta" : { "definition" : { "val" : "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.", "xrefs" : [ 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