BFO:0000051
has_part
has_part
U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.
RO:0002160
never_outside_taxon
specific_to
specific_to_taxon
only_in_taxon
only_in_taxon
RO:0002180
has_component
has_component
RO:0002215
capable_of
capable_of
RO:0002330
RO:0002353
output_of
output_of
A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer c if and only if P has_component multiple instances of c and each instance of c is covalently attached to another instance of c.
has_constituent_monomer
has_constituent_monomer
has_constituent_monomer
See document https://docs.google.com/document/d/15iVMtMyYbQSlvUDgn2XUaDzpwkB0USZI for full definition.
has_gene_template
has_gene_template
has_gene_template
An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
natural protein
native protein
protein
A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain.
TGF-beta superfamily
TGF-beta-like cystine-knot cytokine
A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions.
IFN-gamma
IFNG
immune interferon
interferon gamma
A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY.
MAPK
kinase-related transforming protein
mitogen-activated protein kinase
A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches.
small GTPase
A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229).
tumor necrosis factor, TNF-like
A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors.
bone morphogenetic protein
A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation.
transforming growth factor beta
TGF-beta
A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation.
NODAL
nodal protein
A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.
CD4
T-cell differentiation antigen L3T4
T-cell surface antigen T4/Leu-3
T-cell surface glycoprotein CD4
CD4 molecule
A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain.
interleukin-1
A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses.
IL17
fam:IL-17
interleukin-17
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
class 1 G-protein coupled receptor
class A G-protein coupled receptor
fam:rhodopsin
rhodopsin-like G-protein coupled receptor
A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding.
class 2 G-protein coupled receptor
class B G-protein coupled receptor
fam:secretin
subfamily B1 G-protein coupled receptor
secretin-like G-protein coupled receptor
A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582).
fam:TLR
Toll-like receptor
A complement peptide receptor whose active form binds C5a anaphylatoxin.
C5a anaphylatoxin chemotactic receptor
An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof.
IL-17E
IL-25
IL25
interleukin-17E
IL17E
UNQ3120/PRO10272
interleukin-25
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.
alpha-1 adrenergic receptor
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase.
alpha-2 adrenergic receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix.
opsin receptor
type II opsin
animal opsin
A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin.
APLNR
G-protein coupled receptor APJ
G-protein coupled receptor HG11
angiotensin receptor-like 1
AGTRL1
APJ
MSR
apelin receptor
An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase.
beta adrenergic receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B.
bombesin receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin.
bradykinin receptor
A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.
chemokine receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK).
fam:CCK_R
cholecystokinin receptor
A leukotriene receptor that in active form binds cysteinyl leukotriene.
cysteinyl leukotriene receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins.
endothelin receptor
A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence.
growth hormone secretagogue/motilin receptor
An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof.
IL-17D
IL-27
IL17D
interleukin-27
IL27
UNQ3096/PRO21175
interleukin-17D
A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone.
melanocortin receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides.
tachykinin receptor
A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof.
CD282
TLR2
Toll/interleukin-1 receptor-like protein 4
TIL4
Toll-like receptor 2
A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof.
Toll
CD284
TLR4
Lps
Toll-like receptor 4
A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
B1R
BDKRB1
BK-1 receptor
BRADYB1
Bdkrb
B1 bradykinin receptor
A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin.
B2R
BDKRB2
BK-2 receptor
BKR2
B2 bradykinin receptor
A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH.
ACTH receptor
ACTH-R
MC2-R
MC2R
adrenocorticotropin receptor
melanocortin receptor 2
ACTHR
adrenocorticotropic hormone receptor
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof.
ADRA1A
alpha-1A adrenoceptor
alpha-1A adrenoreceptor
alpha-1C adrenergic receptor
alpha-adrenergic receptor 1c
ADRA1C
alpha-1A adrenergic receptor
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof.
ADRA1B
alpha-1B adrenoceptor
alpha-1B adrenoreceptor
alpha-1B adrenergic receptor
An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof.
ADRA1D
alpha-1D adrenoceptor
alpha-1D adrenoreceptor
alpha-adrenergic receptor 1a
ADRA1A
Gpcr8
alpha-1A adrenergic receptor
alpha-1D adrenergic receptor
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof.
ADRA2A
alpha-2 adrenergic receptor subtype C10
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR
ADRA2R
ADRAR
alpha-2A adrenergic receptor
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof.
ADRA2B
alpha-2 adrenergic receptor subtype C2
alpha-2B adrenoceptor
alpha-2B adrenoreceptor
alpha-2BAR
ADRA2L1
ADRA2RL1
alpha-2B adrenergic receptor
An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof.
ADRA2C
alpha-2 adrenergic receptor subtype C4
alpha-2C adrenoceptor
alpha-2C adrenoreceptor
alpha-2CAR
ADRA2L2
ADRA2RL2
alpha-2C adrenergic receptor
A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof.
ADRB1
beta-1 adrenoceptor
beta-1 adrenoreceptor
ADRB1R
B1AR
beta-1 adrenergic receptor
A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof.
ADRB2
beta(2)-adrenergic receptor
beta-2 adrenoceptor
beta-2 adrenoreceptor
ADRB2R
B2AR
beta-2 adrenergic receptor
A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof.
ADRB3
beta-3 adrenoceptor
beta-3 adrenoreceptor
ADRB3R
B3AR
B3bar
beta-3 adrenergic receptor
A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.
chemokine receptor CCR1/3/1L
A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13.
C-C CKR-2
CC-CKR-2
CCR-2
CCR2
CD192
JE/FIC receptor
MCP-1 receptor
MCP-1-R
chemokine receptor CCR2
monocyte chemoattractant protein 1 receptor
CMKBR2
C-C chemokine receptor type 2
A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20.
C-C CKR-6
CC-CKR-6
CCR-6
CCR6
CD196
CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
GPRCY4
KY411
LARC receptor
chemokine receptor CCR6
chemokine receptor-like 3
CKRL3
CMKBR6
GPR29
STRL22
C-C chemokine receptor type 6
A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.
BLR2
C-C CKR-7
CC-CKR-7
CCR-7
CCR7
CD197
CDw197
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
chemokine receptor CCR7
epstein-Barr virus-induced G-protein coupled receptor 1
CMKBR7
EBI1
EVI1
Ebi1h
C-C chemokine receptor type 7
A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1.
C-X3-C CKR-1
CMK-BRL-1
CMK-BRL1
CX3CR1
G-protein coupled receptor 13
V28
beta chemokine receptor-like 1
chemokine receptor CX3CR1
fractalkine receptor
CMKBRL1
GPR13
CX3C chemokine receptor 1
A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12.
CD184
CXC-R4
CXCR-4
CXCR4
FB22
HM89
LCR1
LESTR
NPYRL
PB-CKR
SDF-1 receptor
chemokine receptor CXCR4
fusin
leukocyte-derived seven transmembrane domain receptor
pre-B-cell-derived chemokine receptor
stromal cell-derived factor 1 receptor
Cmkar4
Sdf1r
C-X-C chemokine receptor type 4
A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2.
G-protein coupled receptor 5
SCM1 receptor
XC chemokine receptor 1
XCR1
chemokine receptor XCR1
lymphotactin receptor
CCXCR1
GPR5
chemokine XC receptor 1
An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3.
ET-A
EDNRA
ET-AR
ETA-R
endothelin A receptor
endothelin receptor A
endothelin receptor type A
ETA
ETRA
Gpcr10
endothelin-1 receptor
A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide.
GRP-R
GRP-preferring bombesin receptor
GRPR
gastrin-releasing peptide receptor
A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands.
GH-releasing peptide receptor
GHRP
GHS-R
GHSR
ghrelin receptor
growth hormone secretagogue receptor
A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle.
G-protein coupled receptor 38
MLNR
GPR38
MTLR
MTLR1
motilin receptor
An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof.
RHO
opsin-2
OPN2
rhodopsin
A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.
C-C CKR-3
CC-CKR-3
CCR-3
CCR3
CD193
CKR3
MIP-1 alpha RL2
chemokine receptor CCR3
eosinophil eotaxin receptor
macrophage inflammatory protein 1-alpha receptor-like 2
CMKBR3
Cmkbr1l2
C-C chemokine receptor type 3
A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts.
class F G-protein coupled receptor
fam:frizzled
frizzled-like G-protein coupled receptor
A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof.
IL-7
IL7
interleukin-7
A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
cadherin
A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain.
class 2 cytokine, IL-10 type
A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens.
erythrocyte membrane protein Rh
A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution.
fibroblast growth factor receptor
A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains.
CD114
CSF3R
G-CSF receptor
G-CSF-R
Csfgr
GCSFR
granulocyte colony-stimulating factor receptor
A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam.
ICAM
intercellular adhesion molecule 1/3
A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof.
AGIF
IL-11
IL11
adipogenesis inhibitory factor
oprelvekin
interleukin-11
A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35.
CLMF p35
IL-12 subunit p35
IL-12A
IL12A
NK cell stimulatory factor chain 1
cytotoxic lymphocyte maturation factor 35 kDa subunit
NKSF1
interleukin-12 subunit alpha
A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23.
CLMF p40
IL-12 subunit p40
IL-12B
IL12B
NK cell stimulatory factor chain 2
cytotoxic lymphocyte maturation factor 40 kDa subunit
NKSF2
interleukin-12 subunit beta
A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related.
IL-13
IL13
T-cell activation protein P600
NC30
interleukin-13
A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof.
IL-15
IL15
interleukin-15
A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof.
IL16
interleukin-16
A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof.
IFN-gamma-inducing factor
IL-1 gamma
IL-18
IL18
iboctadekin
interferon gamma-inducing factor
interleukin-1 gamma
IGIF
IL1F4
interleukin-18
A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity.
IL-2
IL2
T-cell growth factor
TCGF
aldesleukin
interleukin-2
A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof.
IL-21
IL21
Za11
interleukin-21
A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof.
IL-10-related T-cell-derived-inducible factor
IL-22
IL-22a
IL-TIF
IL-TIF alpha
IL22
cytokine Zcyto18
interleukin-22a
ILTIF
Il22a
Iltifa
UNQ3099/PRO10096
ZCYTO18
interleukin-22
A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof.
IL-3
IL3
MCGF
P-cell-stimulating factor
hematopoietic growth factor
multipotential colony-stimulating factor
Csfmu
mast cell growth factor
interleukin-3
A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof.
IL-1F11
IL-33
IL33
NF-HEV
interleukin-1 family member 11
nuclear factor from high endothelial venules
C9orf26
IL1F11
NFHEV
interleukin-33
A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof.
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
BSF-1
IGG1 induction factor
IL-4
IL4
binetrakin
lymphocyte stimulatory factor 1
pitrakinra
interleukin-4
A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof.
B-cell differentiation factor I
B-cell growth factor II
BCGF-II
IL-5
IL5
T-cell replacing factor
TRF
cytotoxic T-lymphocyte inducer
eosinophil differentiation factor
interleukin-5
A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof.
B-cell hybridoma growth factor
B-cell stimulatory factor 2
BSF-2
CDF
CTL differentiation factor
IFN-beta-2
IL-6
IL6
hybridoma growth factor
interferon beta-2
interleukin HP-1
IFNB2
interleukin-6
A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof.
C-X-C motif chemokine 8
CXCL8
IL-8
MDNCF
MONAP
NAP-1
T-cell chemotactic factor
emoctakin
granulocyte chemotactic protein 1
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
neutrophil-activating protein 1
protein 3-10C
GCP-1
IL8
interleukin-8
A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof.
IL-9
IL9
T-cell growth factor P40
cytokine P40
interleukin-9
A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof.
CD129
IL-9 receptor
IL-9R
IL9R
interleukin-9 receptor
A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof.
H1 histamine receptor
H1R
HH1R
HRH1
Bphs
histamine H1 receptor
A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects.
H2 histamine receptor
H2R
HH2R
HRH2
gastric receptor I
histamine H2 receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein.
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
KISS1R
KiSS-1R
OT7T175
hypogonadotropin-1
kisspeptins receptor
metastin receptor
AXOR12
GPR54
KiSS-1 receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides.
formylpeptide receptor
N-formyl peptide receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine.
adenosine receptor protein
An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof.
CD240D
RHD
RHXIII
Rh polypeptide 2
RhPII
blood group RhD polypeptide
rhesus D antigen
blood group Rh(D) polypeptide
A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof.
CD332
FGFR-2
FGFR2
K-sam
keratinocyte growth factor receptor
BEK
Ect1
KGFR
KSAM
fibroblast growth factor receptor 2
A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin.
galanin receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin).
glycoprotein hormone receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II.
gonadotropin-releasing hormone receptor
An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof.
CD50
CDw50
ICAM-3
ICAM-R
ICAM3
intercellular adhesion molecule 3
A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof. Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds.
CSIF
IL-10
IL10
cytokine synthesis inhibitory factor
interleukin-10
A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof.
IL-19
IL19
NG.1
melanoma differentiation-associated protein-like protein
ZMDA1
interleukin-19
A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof.
IL-20
IL20
cytokine Zcyto10
UNQ852/PRO1801
ZCYTO10
interleukin-20
A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof.
IL-24
IL-4-induced secreted protein
IL24
MDA-7
Th2-specific cytokine FISP
melanoma differentiation-associated gene 7 protein
suppression of tumorigenicity 16 protein
MDA7
ST16
interleukin-24
A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof.
IL-26
IL26
protein AK155
AK155
interleukin-26
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
muscarinic acetylcholine receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
fam:NMU_R
neuromedin U receptor
neuromedin-U receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
opioid receptor protein
A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof.
AQ27
G-protein coupled receptor 103
QRFPR
SP9155
orexigenic neuropeptide QRFP receptor
GPR103
pyroglutamylated RF-amide peptide receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
hypocretin receptor
orexin receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof.
G-protein coupled receptor 10
PRLHR
PrRP receptor
PrRPR
GPR10
GR3
Gm339
prolactin-releasing peptide receptor
A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors.
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
PTGER4
prostaglandin E2 receptor EP4
prostanoid EP4 receptor
PTGER2
Ptgerep4
prostaglandin E2 receptor EP4 subtype
A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes).
prostanoid receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
fam:PAR
proteinase-activated receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin.
somatostatin receptor
A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone.
TRH-R
TRH-R1
TRHR
thyroliberin receptor
thyrotropin-releasing hormone receptor type 1
A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides.
name: vasopressin and oxytocin receptor
vasopressin/oxytocin receptor
A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects.
H3 histamine receptor
H3R
HH3R
HRH3
G-protein coupled receptor 97
GPCR97
histamine H3 receptor
A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
AXOR35
GPRv53
H4R
HH4R
HRH4
Pfi-013
SP9144
G-protein coupled receptor 105
GPCR105
H4 histamine receptor
An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins.
D-OR-1
DOR-1
K56
OPRD1
delta-opioid receptor
MSL-2
OPRD
delta-type opioid receptor
An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin.
K-OR-1
KOR-1
OPRK1
kappa-opioid receptor
MSL-1
OPRK
kappa-type opioid receptor
A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone).
LH/CG-R
LHCGR
LHR
LSH-R
luteinizing hormone receptor
lutropin/choriogonadotropin receptor
LCGR
LGR2
LHRHR
lutropin-choriogonadotropic hormone receptor
An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins.
M-OR-1
MOP
MOR-1
OPRM1
mu opiate receptor
mu opioid receptor
mu-opioid receptor
MOR1
Mor
Oprm
mu-type opioid receptor
An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin.
K3 opiate receptor
KOR-3
OPRL1
ORGC
kappa-type 3 opioid receptor
orphanin FQ receptor
OOR
ORL1
Oprl
nociceptin receptor
A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin.
OT-R
OXTR
oxytocin receptor
A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells.
PGI receptor
PGI2 receptor
PTGIR
prostaglandin I2 receptor
prostanoid IP receptor
PRIPR
prostacyclin receptor
A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types.
PGD receptor
PGD2 receptor
PTGDR
prostanoid DP receptor
prostaglandin D2 receptor
A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals.
PGE receptor EP1 subtype
PGE2 receptor EP1 subtype
PTGER1
prostaglandin E2 receptor EP1
prostanoid EP1 receptor
Ptgerep1
prostaglandin E2 receptor EP1 subtype
A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves.
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
PTGER2
prostaglandin E2 receptor EP2
prostanoid EP2 receptor
Ptgerep2
prostaglandin E2 receptor EP2 subtype
A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney.
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
PGE2-R
PTGER3
prostaglandin E2 receptor EP3
prostanoid EP3 receptor
Ptgerep3
prostaglandin E2 receptor EP3 subtype
A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also.
PGF receptor
PGF2-alpha receptor
PTGFR
prostanoid FP receptor
prostaglandin F2-alpha receptor
A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity.
F2R
PAR-1
coagulation factor II receptor
thrombin receptor
CF2R
PAR1
TR
proteinase-activated receptor 1
A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle.
TBXA2R
TXA2-R
prostanoid TP receptor
thromboxane A2 receptor
A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.
transcription factor NF-kappa-B
transcription factor NF-kappa-B subunit
A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain.
fam:C/C-C chemokine
C/C-C motif small inducible chemokine
A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.
CSF-1/PDGF receptor-type tyrosine-protein kinase
A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757).
EGF receptor type tyrosine-protein kinase
A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714).
HGF/MSP receptor type tyrosine-protein kinase
A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof.
CD118
D-factor/LIF receptor
LIF receptor
LIF-R
LIFR
leukemia inhibitory factor receptor
A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof.
CD228
MELTF
MTf
melanoma-associated antigen p97
membrane-bound transferrin-like protein p97
MAP97
MFI2
melanotransferrin
A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof.
RAR-related orphan receptor C
RORC
TOR
nuclear receptor RZR-gamma
nuclear receptor subfamily 1 group F member 3
retinoid-related orphan receptor-gamma
thymus orphan receptor
NR1F3
RORG
RZRG
Thor
nuclear receptor ROR-gamma
A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679).
semaphorin
A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229).
tumor necrosis factor ligand superfamily member 10/11
A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
vascular endothelial growth factor receptor
A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof.
CCL19
CK beta-11
EBI1 ligand chemokine
MIP-3-beta
beta chemokine exodus-3
epstein-Barr virus-induced molecule 1 ligand chemokine
macrophage inflammatory protein 3 beta
small-inducible cytokine A19
ELC
MIP3B
SCYA19
C-C motif chemokine 19
A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof.
6Ckine
TCA4
small-inducible cytokine A21a
small-inducible cytokine A21b
small-inducible cytokine A21c
thymus-derived chemotactic agent 4
CCL21
SLC
beta chemokine exodus-2
secondary lymphoid-tissue chemokine
small-inducible cytokine A21
Ccl21b
Ccl21c
SCYA21
Scya21b
Scya21c
UNQ784/PRO1600
C-C motif chemokine 21
A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin.
eotaxin-like cytokine
A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.
CD117
KIT
proto-oncogene c-Kit
tyrosine-protein kinase Kit
SCFR
Sl
mast/stem cell growth factor receptor
A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof.
CCL5
EoCP
RANTES
SIS-delta
T cell-specific protein P228
T-cell-specific protein RANTES
TCP228
small inducible cytokine A5
small-inducible cytokine A5
D17S136E
SCYA5
eosinophil chemotactic cytokine
C-C motif chemokine 5
A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof.
CD253
TNF-related apoptosis-inducing ligand
TNFSF10
apo-2 ligand
apo-2L
protein TRAIL
APO2L
TRAIL
tumor necrosis factor ligand superfamily member 10
A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof.
CD254
ODF
TNF-related activation-induced cytokine
TNFSF11
osteoclast differentiation factor
osteoprotegerin ligand
receptor activator of nuclear factor kappa-B ligand
OPGL
RANKL
TRANCE
tumor necrosis factor ligand superfamily member 11
A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
CD309
FLK-1
KDR
VEGFR-2
fetal liver kinase 1
kinase NYK
kinase insert domain receptor
protein-tyrosine kinase receptor flk-1
FLK1
VEGFR2
vascular endothelial growth factor receptor 2
An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof.
MCP-1
CCL2
HC11
MCAF
monocyte chemoattractant protein 1
monocyte chemotactic and activating factor
monocyte chemotactic protein 1
monocyte secretory protein JE
platelet-derived growth factor-inducible protein JE
small-inducible cytokine A2
Je
MCP1
SCYA2
C-C motif chemokine 2
An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof.
CCL7
MCP-3
NC28
intercrine/chemokine MARC
monocyte chemoattractant protein 3
monocyte chemotactic protein 3
protein FIC
small-inducible cytokine A7
Fic
MCP3
SCYA6
SCYA7
C-C motif chemokine 7
An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof.
PKB
AKT1
AKT1 kinase
PKB alpha
RAC-PK-alpha
protein kinase B
protein kinase B alpha
proto-oncogene c-Akt
thymoma viral proto-oncogene
Akt
RAC
RAC-alpha serine/threonine-protein kinase
A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof.
CTNNB1
beta-catenin
CTNNB
Catnb
OK/SW-cl.35
PRO2286
catenin beta-1
A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221).
dynein light chain
A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof.
LT-alpha
LTA
TNF-beta
tumor necrosis factor B
tumor necrosis factor ligand superfamily member 1
TNFB
TNFSF1
lymphotoxin-alpha
A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof.
TP53
antigen NY-CO-13
phosphoprotein p53
tumor suppressor p53
P53
Trp53
cellular tumor antigen p53
A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).
NFAT protein
An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof.
NF-ATc
NF-ATc1
NFAT transcription complex cytosolic component
NFATC1
NFATc
NFATc1
NFAT2
NFATC
nuclear factor of activated T-cells, cytoplasmic 1
A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain.
fam:14-3-3
14-3-3 protein
A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain.
Hsp70 family chaperone
A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof.
ACR
ACRS
acrosin
A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof.
ADCYAP1
PACAP
pituitary adenylate cyclase-activating polypeptide
A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.
30 kDa adipocyte complement-related protein
ADIPOQ
adipocyte complement-related 30 kDa protein
adipocyte, C1q and collagen domain-containing protein
adipocyte-specific protein AdipoQ
adipose most abundant gene transcript 1 protein
apM-1
gelatin-binding protein
ACDC
ACRP30
APM1
GBP28
adiponectin
A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof.
AHR
Ah receptor
AhR
bHLHe76
class E basic helix-loop-helix protein 76
BHLHE76
aryl hydrocarbon receptor
A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof.
APJ endogenous ligand
APLN
APEL
apelin
A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof.
APOA1
ApoA-I
apo-AI
apolipoprotein A1
apolipoprotein A-I
A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof.
ABPP
AG
APP
APPI
CVAP
PN-II
PreA4
alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta A4 protein
amyloid precursor protein
amyloid-beta (A4) precursor protein
amyloid-beta A4 protein
amyloidogenic glycoprotein
cerebral vascular amyloid peptide
protease nexin-II
A4
AD1
amyloid-beta precursor protein
A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof.
AR
dihydrotestosterone receptor
nuclear receptor subfamily 3 group C member 4
DHTR
NR3C4
androgen receptor
A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof.
B2M
CDABP0092
HDCMA22P
beta-2-microglobulin
A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof.
BDNF
abrineurin
brain-derived neurotrophic factor
A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof.
CALCR
CT-R
calcitonin receptor
A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
CALM
CaM
CAM3
CALML2
CAMC
CAMIII
calmodulin
A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof.
CCK
cholecystokinin
A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof.
CG-alpha
CGA
FSH-alpha
LSH-alpha
TSH-alpha
anterior pituitary glycoprotein hormones common subunit alpha
choriogonadotropin alpha chain
chorionic gonadotrophin subunit alpha
follicle-stimulating hormone alpha chain
follitropin alpha chain
luteinizing hormone alpha chain
lutropin alpha chain
thyroid-stimulating hormone alpha chain
thyrotropin alpha chain
glycoprotein hormones alpha chain
A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof.
CNTF
ciliary neurotrophic factor
A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof.
CRF-R-1
CRF-R1
CRFR-1
CRH-R-1
CRH-R1
CRHR1
corticotropin-releasing hormone receptor 1
CRFR
CRFR1
CRHR
corticotropin-releasing factor receptor 1
A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof.
CRF-R-2
CRF-R2
CRF-RB
CRFR-2
CRH-R-2
CRH-R2
CRHR2
corticotropin-releasing hormone receptor 2
CRF2R
CRH2R
corticotropin-releasing factor receptor 2
A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof.
CSF
CSF2
GM-CSF
colony-stimulating factor
molgramostin
sargramostim
Csfgm
GMCSF
granulocyte-macrophage colony-stimulating factor
A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof.
CSF3
G-CSF
filgrastim
lenograstim
pluripoietin
C17orf33
Csfg
GCSF
granulocyte colony-stimulating factor
A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof.
CTNND2
GT24
delta-catenin
neural plakophilin-related ARM-repeat protein
neurojungin
Catnd2
NPRAP
catenin delta-2
An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof.
MCP-5
Ccl12
MCP-1-related chemokine
monocyte chemoattractant protein 5
monocyte chemotactic protein 5
small-inducible cytokine A12
Mcp5
Scya12
C-C motif chemokine 12
A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof.
DAG1
dystroglycan
dystrophin-associated glycoprotein 1
Dag-1
dystroglycan 1
A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof.
EEF2
EF-2
EF2
elongation factor 2
A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof.
EGF
pro-epidermal growth factor
An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof.
EGFR
proto-oncogene c-ErbB-1
receptor tyrosine-protein kinase erbB-1
ERBB
ERBB1
HER1
epidermal growth factor receptor
A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof.
EIF4E
eIF-4E
eIF-4F 25 kDa subunit
eIF4E
mRNA cap-binding protein
EIF4EL1
EIF4F
eukaryotic translation initiation factor 4E
A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof.
EPO
epoetin
erythropoietin
A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof.
EPO-R
EPOR
erythropoietin receptor
A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof.
ER
ER-alpha
ESR1
estradiol receptor
nuclear receptor subfamily 3 group A member 1
ESR
Estr
Estra
NR3A1
estrogen receptor
A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof.
FGF-3
FGF3
HBGF-3
INT-2 proto-oncogene protein
heparin-binding growth factor 3
proto-oncogene Int-2
INT2
Int-2
fibroblast growth factor 3
A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof.
HST
FGF-4
FGF4
HBGF-4
HST-1
HSTF-1
K-fibroblast growth factor
heparin secretory-transforming protein 1
heparin-binding growth factor 4
transforming protein KS3
HSTF1
KS3
Kfgf
fibroblast growth factor 4
A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof.
FGF-5
FGF5
HBGF-5
Smag-82
heparin-binding growth factor 5
fibroblast growth factor 5
A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof.
FGF-6
FGF6
HBGF-6
HST-2
HSTF-2
heparin secretory-transforming protein 2
heparin-binding growth factor 6
HST2
HSTF2
fibroblast growth factor 6
A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof.
ABP-280
FLN-A
FLNA
actin-binding protein 280
alpha-filamin
endothelial actin-binding protein
filamin-1
non-muscle filamin
FLN
FLN1
filamin-A
A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof.
actin-binding-like protein
ABP-278
ABP-280 homolog
FLN-B
FLNB
Fh1
beta-filamin
filamin homolog 1
filamin-3
thyroid autoantigen
truncated ABP
truncated actin-binding protein
ABP-280-like protein
FLN1L
FLN3
TABP
TAP
filamin-B
A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof.
actin-binding-like protein
ABP-L
FLN-C
FLNC
FLNc
filamin-2
gamma-filamin
ABP-280-like protein
ABPL
FLN2
filamin-C
A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof.
FLT-1
FLT1
Fms-like tyrosine kinase 1
VEGFR-1
embryonic receptor kinase 2
tyrosine-protein kinase FRT
tyrosine-protein kinase receptor FLT
vascular permeability factor receptor
Emrk2
FLT
FRT
VEGFR1
vascular endothelial growth factor receptor 1
A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof.
FLT-4
FLT4
Fms-like tyrosine kinase 4
VEGFR-3
tyrosine-protein kinase receptor FLT4
VEGFR3
vascular endothelial growth factor receptor 3
A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof.
CIG
FN1
cold-insoluble globulin
FN
fibronectin
A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof.
GAL
GAL1
GALN
GLNN
galanin
A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.
GAST
GAS
gastrin
A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof.
GCGR
GL-R
glucagon receptor
A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof.
GTP cyclohydrolase I
GTP-CH-I
GCH1
DYT5
GCH
GTP cyclohydrolase 1
A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof.
ATF
GDNF
astrocyte-derived trophic factor
glial cell line-derived neurotrophic factor
A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof.
GH receptor
GHR
somatotropin receptor
growth hormone receptor
A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof.
GHRH
GRF
growth hormone-releasing factor
growth hormone-releasing hormone
sermorelin
somatocrinin
somatorelin
GHRF
somatoliberin
A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof.
GHRH receptor
GHRHR
GRF receptor
GRFR
growth hormone-releasing factor receptor
growth hormone-releasing hormone receptor
A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof.
GHRL
growth hormone secretagogue
growth hormone-releasing peptide
motilin-related peptide
protein M46
MTLRP
UNQ524/PRO1066
appetite-regulating hormone
A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof.
GIP-R
GIPR
glucose-dependent insulinotropic polypeptide receptor
gastric inhibitory polypeptide receptor
A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof.
HCRT
Hcrt
hypocretin
orexin
orexin precursor
prepro-orexin
preprohypocretin
OX
PPORX
PPOX
hypocretin neuropeptide precursor
A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof.
HGF
SF
hepatopoeitin-A
hepatopoietin-A
scatter factor
HPTA
hepatocyte growth factor
A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof.
HMG-1
HMGB1
high mobility group protein 1
HMG1
high mobility group protein B1
A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof.
HMG-CoA reductase
HMGCR
3-hydroxy-3-methylglutaryl-coenzyme A reductase
A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof.
HP
haptoglobin
A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof.
DAP
IAPP
amylin
diabetes-associated peptide
insulinoma amyloid peptide
islet amyloid polypeptide
A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof.
BSP II
IBSP
bone sialoprotein II
cell-binding sialoprotein
integrin-binding sialoprotein
BNSP
bone sialoprotein 2
A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof.
IDH
IDP
NADP(+)-specific ICDH
oxalosuccinate decarboxylase
ICD-M
IDH2nadp
IDH2
isocitrate dehydrogenase [NADP], mitochondrial
A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof.
IFIH1
MDA-5
RIG-I-like receptor 2
RLR-2
RNA helicase-DEAD box protein 116
helicard
helicase with 2 CARD domains
interferon induced with helicase C domain protein 1
interferon-induced with helicase C domain protein 1
melanoma differentiation-associated protein 5
murabutide down-regulated protein
MDA5
RH116
interferon-induced helicase C domain-containing protein 1
A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof.
IGF-II
IGF2
multiplication-stimulating polypeptide
somatomedin-A
Igf-2
PP1446
insulin-like growth factor II
A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof.
CD360
IL-21 receptor
IL-21R
IL21R
LR-beta
NR8
lymphocyte receptor beta
novel cytokine receptor 8
novel interleukin receptor
NILR
UNQ3121/PRO10273
interleukin-21 receptor
A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof.
IL-23 receptor
IL-23R
IL23R
interleukin-23 receptor
An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.
insulin
INS
insulin gene translation product
A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof.
CD220
INSR
IR
insulin receptor
A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof.
IGF-I
MGF
IGF1
mechano growth factor
somatomedin
somatomedin-C
IBP1
Igf-1
insulin-like growth factor I
A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof.
MGF
KITLG
c-Kit ligand
hematopoietic growth factor KL
steel factor
stem cell factor
Kitl
SCF
Sl
Slf
mast cell growth factor
kit ligand
A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof.
D factor
LIF
MLPLI
differentiation-stimulating factor
emfilermin
melanoma-derived LPL inhibitor
HILDA
leukemia inhibitory factor
A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.
LTF
lactoferrin
talalactoferrin
GIG12
LF
lactotransferrin
An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof.
HGF receptor
HGF/SF receptor
MET
SF receptor
proto-oncogene c-Met
scatter factor receptor
tyrosine-protein kinase Met
hepatocyte growth factor receptor
A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof.
DER6
L-dopachrome isomerase
MIF
delayed early response protein 6
glycosylation-inhibiting factor
phenylpyruvate tautomerase
GIF
GLIF
L-dopachrome tautomerase
MMIF
macrophage migration inhibitory factor
A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof.
MAP3K21
mitogen-activated protein kinase kinase kinase MLK4
mixed lineage kinase 4
KIAA1804
MLK4
mitogen-activated protein kinase kinase kinase 21
A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof.
MYF5
bHLHc2
class C basic helix-loop-helix protein 2
BHLHC2
Myf-5
myogenic factor 5
A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof.
BBM-I
BBMI
MIHC
MYO1A
brush border myosin I
myosin I heavy chain
MYHL
myosin-Ia
A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof.
MYOD1-related protein
MYOG
Myf-4
bHLHc3
class C basic helix-loop-helix protein 3
myogenic factor 4
BHLHC3
MYF4
myogenin
A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof.
MYOZ1
calsarcin-2
filamin-, actinin- and telethonin-binding protein
protein FATZ
MYOZ
myozenin-1
A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof.
NEDD-8
NEDD8
neddylin
neural precursor cell expressed developmentally down-regulated protein 8
ubiquitin-like protein Nedd8
NEDD8 protein
A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof.
NF-ATc2
NF-ATp
NFAT pre-existing subunit
NFATC2
NFATc2
T-cell transcription factor NFAT1
NFAT1
NFATP
nuclear factor of activated T-cells, cytoplasmic 2
A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof.
NF-AT4
NF-ATc3
NFATC3
NFATc3
NFATx
T-cell transcription factor NFAT4
NFAT4
nuclear factor of activated T-cells, cytoplasmic 3
A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof.
NF-AT3
NF-ATc4
NFATC4
NFATc4
T-cell transcription factor NFAT3
NFAT3
nuclear factor of activated T-cells, cytoplasmic 4
A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof.
NGF
beta-NGF
NGFB
beta-nerve growth factor
A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof.
ANF
CDD
CDD-ANF
NPPA
atrial natriuretic factor prohormone
atrial natriuretic peptide
atrial natriuretic peptide prohormone
atriopeptigen
cardiodilatin
preproANP
preproCDD-ANF
prepronatriodilatin
proANF
proANP
ANP
PND
atrial natriuretic factor
A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof.
NPY
neuropeptide Y
A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof.
NR3C1
nuclear receptor subfamily 3 group C member 1
GR
GRL
Grl1
glucocorticoid receptor
A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof.
MR
NR3C2
nuclear receptor subfamily 3 group C member 2
MCR
MLR
mineralocorticoid receptor
A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof.
HDNF
NGF-2
NT-3
NTF3
nerve growth factor 2
neurotrophic factor
Ntf-3
neurotrophin-3
A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof.
OSM
oncostatin-M
A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof.
PCNA
cyclin
proliferating cell nuclear antigen
A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof.
PGR
PR
nuclear receptor subfamily 3 group C member 3
NR3C3
progesterone receptor
A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
PIGR
PIgR
hepatocellular carcinoma-associated protein TB6
poly-Ig receptor
polymeric immunoglobulin receptor
A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof.
PLAU
U-plasminogen activator
uPA
urokinase-type plasminogen activator
A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof.
PP
PPY
obinepitide
pancreatic polypeptide
PNP
pancreatic prohormone
A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.
PRL
prolactin
A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof.
PRL-R
PRLR
prolactin receptor
A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.
PTH
parathormone
parathyrin
parathyroid hormone
A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof.
PYY
PYY-I
peptide tyrosine tyrosine
peptide YY
A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof.
GAP
GTPase-activating protein
RASA1
RasGAP
p120GAP
ras p21 protein activator
RASA
Ras GTPase-activating protein 1
An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.
REN
angiotensinogenase
renin
A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof.
RPS27A
ubiquitin carboxyl extension protein 80
40S ribosomal protein S27a
UBA80
UBCEP1
ubiquitin-40S ribosomal protein S27a
A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof.
SCT
secretin
A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof.
SCT-R
SCTR
secretin receptor
A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof.
I-2PP2A
IGAAD
PHAPII
SET
TAF-I
inhibitor of granzyme A-activated DNase
phosphatase 2A inhibitor I2PP2A
template-activating factor I
HLA-DR-associated protein II
protein SET
A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof.
SMO
protein Gx
SMOH
smoothened
A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof.
STX2
epimorphin
EPIM
STX2A
STX2B
STX2C
syntaxin-2
A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof.
STX3
STX3A
syntaxin-3
A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof.
STX5
STX5A
syntaxin-5
A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof.
STX6
syntaxin-6
A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof.
APT1
ATP-binding cassette sub-family B member 2
PSF-1
TAP1
histocompatibility antigen modifier 1
peptide supply factor 1
peptide transporter PSF1
peptide transporter TAP1
peptide transporter involved in antigen processing 1
really interesting new gene 4 protein
ABCB2
Ham-1
Ham1
PSF1
RING4
Y3
antigen peptide transporter 1
A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof.
APT2
ATP-binding cassette sub-family B member 3
PSF-2
TAP2
histocompatibility antigen modifier 2
peptide supply factor 2
peptide transporter PSF2
peptide transporter TAP2
peptide transporter involved in antigen processing 2
really interesting new gene 11 protein
ABCB3
Ham-2
Ham2
PSF2
RING11
Y1
antigen peptide transporter 2
A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof.
NGS-17
TAP-associated protein
TAP-binding protein
TAPBP
TPN
TPSN
NGS17
TAPA
tapasin
A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof.
TCAP
titin cap protein
telethonin
A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof.
TF
beta-1 metal-binding globulin
siderophilin
transferrin
PRO1400
Trf
serotransferrin
A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof.
TH
tyrosine 3-hydroxylase
TYH
tyrosine 3-monooxygenase
A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof.
DNA topoisomerase I
TOP1
Top-1
type 1B DNA topoisomerase 1
A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof.
TSH-B
TSH-beta
TSHB
thyroid-stimulating hormone subunit beta
thyrotropin alfa
thyrotropin beta chain
thyrotropin subunit beta
A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof.
TTN
connectin
rhabdomyosarcoma antigen MU-RMS-40.14
titin
A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof.
CEP52
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
60S ribosomal protein L40
UBCEP2
ubiquitin-60S ribosomal protein L40
A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof.
UBC
polyubiquitin-C
A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof.
UBD
diubiquitin
ubiquitin-like protein FAT10
FAT10
ubiquitin D
A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof.
VCL
metavinculin
vinculin
A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof.
1,25-dihydroxyvitamin D3 receptor
VDR
nuclear receptor subfamily 1 group I member 1
NR1I1
vitamin D3 receptor
2
An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
peptide
polypeptide
amino acid chain
A protein that is produced as the result of proteolytic processing of a longer protein.
ClvPrd
peptide
polypeptide
proteolytic cleavage product
An interferon gamma that has been processed by proteolytic cleavage.
IFNG/ClvPrd
interferon gamma proteolytic cleavage product
An interleukin-16 that has been processed by proteolytic cleavage.
IL16/ClvPrd
interleukin-16 proteolytic cleavage product
An interleukin-18 that has been processed by proteolytic cleavage.
IL18/ClvPrd
interleukin-18 proteolytic cleavage product
An interleukin-8 that has been processed by proteolytic cleavage.
CXCL8/ClvPrd
interleukin-8 proteolytic cleavage product
A proteinase-activated receptor 1 that has been processed by proteolytic cleavage.
F2R/ClvPrd
proteinase-activated receptor 1 proteolytic cleavage product
A C-C motif chemokine 5 that has been processed by proteolytic cleavage.
CCL5/ClvPrd
C-C motif chemokine 5 proteolytic cleavage product
A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage.
TNFSF11/ClvPrd
tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
An acrosin that has been processed by proteolytic cleavage.
ACR/ClvPrd
acrosin proteolytic cleavage product
A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage.
ADCYAP1/ClvPrd
pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product
An aryl hydrocarbon receptor that has been processed by proteolytic cleavage.
AHR/ClvPrd
aryl hydrocarbon receptor proteolytic cleavage product
An apolipoprotein A-I that has been processed by proteolytic cleavage.
APOA1/ClvPrd
apolipoprotein A-I proteolytic cleavage product
An amyloid-beta precursor protein that has been processed by proteolytic cleavage.
APP/ClvPrd
amyloid-beta precursor protein proteolytic cleavage product
A beta-2-microglobulin that has been processed by proteolytic cleavage.
B2M/ClvPrd
beta-2-microglobulin proteolytic cleavage product
A brain-derived neurotrophic factor that has been processed by proteolytic cleavage.
BDNF/ClvPrd
brain-derived neurotrophic factor proteolytic cleavage product
A cholecystokinin that has been processed by proteolytic cleavage.
CCK/ClvPrd
cholecystokinin proteolytic cleavage product
A dystroglycan 1 that has been processed by proteolytic cleavage.
DAG1/ClvPrd
dystroglycan 1 proteolytic cleavage product
A pro-epidermal growth factor that has been processed by proteolytic cleavage.
EGF/ClvPrd
pro-epidermal growth factor proteolytic cleavage product
An erythropoietin that has been processed by proteolytic cleavage.
EPO/ClvPrd
erythropoietin proteolytic cleavage product
A fibronectin that has been processed by proteolytic cleavage.
FN1/ClvPrd
fibronectin proteolytic cleavage product
A galanin that has been processed by proteolytic cleavage.
GAL/ClvPrd
galanin proteolytic cleavage product
A gastrin that has been processed by proteolytic cleavage.
GAST/ClvPrd
gastrin proteolytic cleavage product
A growth hormone receptor that has been processed by proteolytic cleavage.
GHR/ClvPrd
growth hormone receptor proteolytic cleavage product
A somatoliberin that has been processed by proteolytic cleavage.
GHRH/ClvPrd
somatoliberin proteolytic cleavage product
An appetite-regulating hormone that has been processed by proteolytic cleavage.
GHRL/ClvPrd
appetite-regulating hormone proteolytic cleavage product
A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage.
HCRT/ClvPrd
hypocretin neuropeptide precursor proteolytic cleavage product
A hepatocyte growth factor that has been processed by proteolytic cleavage.
HGF/ClvPrd
hepatocyte growth factor proteolytic cleavage product
A haptoglobin that has been processed by proteolytic cleavage.
HP/ClvPrd
haptoglobin proteolytic cleavage product
An islet amyloid polypeptide that has been processed by proteolytic cleavage.
IAPP/ClvPrd
islet amyloid polypeptide proteolytic cleavage product
An insulin-like growth factor II that has been processed by proteolytic cleavage.
IGF2/ClvPrd
insulin-like growth factor II proteolytic cleavage product
An insulin receptor that has been processed by proteolytic cleavage.
INSR/ClvPrd
insulin receptor proteolytic cleavage product
An insulin-like growth factor I that has been processed by proteolytic cleavage.
IGF1/ClvPrd
insulin-like growth factor I proteolytic cleavage product
A lactotransferrin that has been processed by proteolytic cleavage.
LTF/ClvPrd
lactotransferrin proteolytic cleavage product
A NEDD8 protein that has been processed by proteolytic cleavage.
NEDD8/ClvPrd
NEDD8 protein proteolytic cleavage product
A beta-nerve growth factor that has been processed by proteolytic cleavage.
NGF/ClvPrd
beta-nerve growth factor proteolytic cleavage product
An atrial natriuretic factor that has been processed by proteolytic cleavage.
NPPA/ClvPrd
atrial natriuretic factor proteolytic cleavage product
A neuropeptide Y that has been processed by proteolytic cleavage.
NPY/ClvPrd
neuropeptide Y proteolytic cleavage product
A neurotrophin-3 that has been processed by proteolytic cleavage.
NTF3/ClvPrd
neurotrophin-3 proteolytic cleavage product
An oncostatin-M that has been processed by proteolytic cleavage.
OSM/ClvPrd
oncostatin-M proteolytic cleavage product
A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
PIGR/ClvPrd
polymeric immunoglobulin receptor proteolytic cleavage product
A urokinase-type plasminogen activator that has been processed by proteolytic cleavage.
PLAU/ClvPrd
urokinase-type plasminogen activator proteolytic cleavage product
A pancreatic prohormone that has been processed by proteolytic cleavage.
PPY/ClvPrd
pancreatic prohormone proteolytic cleavage product
A parathyroid hormone that has been processed by proteolytic cleavage.
PTH/ClvPrd
parathyroid hormone proteolytic cleavage product
A peptide YY that has been processed by proteolytic cleavage.
PYY/ClvPrd
peptide YY proteolytic cleavage product
A secretin that has been processed by proteolytic cleavage.
SCT/ClvPrd
secretin proteolytic cleavage product
A thyrotropin subunit beta that has been processed by proteolytic cleavage.
TSHB/ClvPrd
thyrotropin subunit beta proteolytic cleavage product
A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.
neurotrophin
A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling.
death receptor
A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof.
ATP pyrophosphate-lyase
adenylyl cyclase
cyaA
cya
adenylate cyclase
A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof.
MCP-IV
dipeptide chemoreceptor protein
tap
methyl-accepting chemotaxis protein IV
A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof.
HK
HSK
thrB
homoserine kinase
A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains.
IFN type II
interferon type II
interferon gamma
type II interferon
An Hsp70 family chaperone that contains an ATPase and HSP90 domains.
HSP90
HSPC protein
A nodal protein that has been processed by proteolytic cleavage.
NODAL/ClvPrd
nodal protein proteolytic cleavage product
A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647).
ephrin receptor
A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains.
IFN type I
interferon type I
type I interferon
A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2.
IFN type III
interferon type III
interferon lambda
type III interferon
1
1
A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone.
TSH
thyrotropin
thyroid stimulating hormone
A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
PKB
AKT
serine-threonine kinase Akt
AKT kinase
A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof.
ATP-dependent RNA helicase DDX58
DEAD box protein 58
RIG-1
RIG-I
RIG-I-like receptor 1
RIGI
RLR-1
RNA sensor RIG-I
probable ATP-dependent RNA helicase DDX58
retinoic acid-inducible gene 1 protein
retinoic acid-inducible gene I protein
DDX58
antiviral innate immune response receptor RIG-I
A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.
fam:GH1
somatotropin hormone family member
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
7TM receptor
seven-transmembrane receptor
fam:GPCR
G-protein coupled receptor
A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof.
UBB
polyubiquitin-B
A ubiquitin-40S ribosomal protein S27a that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76.
RPS27A/Clv:ubiq
ubiquitin (RPS27A)
A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684).
UBC/Clv:ubiq
ubiquitin (UBC)
A ubiquitin-60S ribosomal protein L40 that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76.
UBA52/Clv:ubiq
ubiquitin (UBA52)
A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228).
UBB/Clv:ubiq
ubiquitin (UBB)
A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76.
Ubiq
ubiquitin
A protein that is encoded in the genome of some Eukaryota.
Eukaryota protein
eukaryotic protein
A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain.
fam:tandemUb
tandem-copy polyubiquitin
A protein that includes at least one phosphorylated residue.
Prot/PhosRes+
phosphorylated protein
phosphoprotein
A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
corticotropin-releasing factor receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
adrenoceptor protein
A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
calcitonin receptor protein
A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
complement peptide receptor
A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges.
glycoprotein hormone beta chain
A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.
fam:INS
insulin family protein
A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
glucagon receptor
glucagon-like receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
histamine receptor
A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
leukotriene receptor
A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
fam:angiotensinogenase
angiotensinogenase
A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity.
thyrotropin-releasing hormone receptor
A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof.
fam:LT
lymphotoxin
A material entity that minimally consists of a protein.
protein
protein aggregate
protein complex
protein-containing complex
protein-containing material entity
1
1
A ubiquitin that is a monomer.
monoUbiq
monoubiquitin