This report generated on 2023-01-02
!gaf-version: 2.2
!
!The set of protein accessions included in this file is based on UniProt complete proteomes, which may provide more than one protein per gene.
!They include all Swiss-Prot entries for the species plus any TrEMBL entries that have an Ensembl DR line. The TrEMBL entries are likely to overlap with the Swiss-Prot entries or their isoforms.
!If a particular protein accession is not annotated with GO, then it will not appear in this file.
!
!Note that the annotation set in this file is filtered in order to reduce redundancy; the full, unfiltered set can be found in
!ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/goa_uniprot_all.gaf.gz
!
!date-generated: 2022-11-17 12:26
!generated-by: UniProt
!go-version: http://purl.obolibrary.org/obo/go/releases/2022-11-12/extensions/go-plus.owl
!
No 'NOT' annotations to 'protein binding ; GO:0005515'
IEP and HEP usage is restricted to terms from the Biological Process ontology
IPI should not be used with GO:0003824 catalytic activity or descendents
No annotations should be made to uninformative high level terms
UniProtKB F1RIT1 TRPV4 located_in GO:0005622 PMID:19790068 IDA C Ion_trans domain-containing protein TRPV4 protein taxon:9823 20150803 AgBase part_of(CL:0000138) UniProtKB:F1RIT1
ND evidence code should be to root nodes only, and no terms other than root nodes can have the evidence code ND
Taxon-appropriate annotation check
Dual species taxon check
With/From: IC annotations require a With/From GO ID
IDA annotations must not have a With/From entry
IPI annotations require a With/From entry
Automatic repair of annotations to merged or obsoleted terms
UniProtKB A0A287AHF4 CLCN3 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Chloride channel protein CLCN3 protein taxon:9823 20221111 GOC UniProtKB:A0A287AHF4
UniProtKB A0A287AL63 SLC9A7 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Sodium/hydrogen exchanger SLC9A7 protein taxon:9823 20221111 GOC UniProtKB:A0A287AL63
UniProtKB A0A287B7R6 CLCN4 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Chloride channel protein CLCN4 protein taxon:9823 20221111 GOC UniProtKB:A0A287B7R6
UniProtKB A0A5G2QWB4 SLC9A2 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Sodium/hydrogen exchanger SLC9A2 protein taxon:9823 20221111 GOC UniProtKB:A0A5G2QWB4
UniProtKB A0A5G2R3P1 SLC9B1 enables GO:0015299 GO_REF:0000002 IEA InterPro:IPR006153 F Na_H_Exchanger domain-containing protein SLC9B1 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R3P1
UniProtKB A0A5G2R3P1 SLC9B1 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Na_H_Exchanger domain-containing protein SLC9B1 protein taxon:9823 20221111 GOC UniProtKB:A0A5G2R3P1
UniProtKB F1S111 SLC9B2 enables GO:0015299 GO_REF:0000002 IEA InterPro:IPR006153 F Na_H_Exchanger domain-containing protein SLC9B2 protein taxon:9823 20221109 InterPro UniProtKB:F1S111
UniProtKB F1S111 SLC9B2 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Na_H_Exchanger domain-containing protein SLC9B2 protein taxon:9823 20221111 GOC UniProtKB:F1S111
UniProtKB F1S5Z3 SARS1 involved_in GO:0097056 GO_REF:0000041 IEA UniPathway:UPA00906 P serine--tRNA ligase SARS1 protein taxon:9823 20221109 UniProt UniProtKB:F1S5Z3
UniProtKB F1SBE3 SLC9A8 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Sodium/hydrogen exchanger SLC9A8 protein taxon:9823 20221111 GOC UniProtKB:F1SBE3
UniProtKB I3LVK4 SLC9B2 enables GO:0015299 GO_REF:0000002 IEA InterPro:IPR006153 F Na_H_Exchanger domain-containing protein SLC9B2 protein taxon:9823 20221109 InterPro UniProtKB:I3LVK4
UniProtKB I3LVK4 SLC9B2 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Na_H_Exchanger domain-containing protein SLC9B2 protein taxon:9823 20221111 GOC UniProtKB:I3LVK4
UniProtKB K7GPQ5 SLC9A6 involved_in GO:1902600 GO_REF:0000108 IEA GO:0015299 P Sodium/hydrogen exchanger SLC9A6 protein taxon:9823 20221111 GOC UniProtKB:K7GPQ5
Aspect can only be one of C, P, F and should be repaired using the GO term
IEAs should be less than one year old.
Deprecated GO_REFs are not allowed
IBA annotations should ONLY be assigned_by GO_Central and have PMID:21873635 as a reference
Protein complexes can not be annotated to GO:0032991 (protein-containing complex) or its descendants
Qualifier: IKR evidence code requires a NOT qualifier
Check for valid combination of evidence code and GO_REF
The ‘with’ field (GAF column 8) must be the same as the gene product (GAF colummn 2) when annotating to ‘self-binding’ terms.
UniProtKB A0A286ZID4 HSPB8 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR043254 F Heat shock protein beta-8 HSPB8 protein taxon:9823 20221109 InterPro UniProtKB:A0A286ZID4
UniProtKB A0A286ZMS0 TERF1 enables GO:0042803 GO_REF:0000104 IEA UniRule:UR000734782 F Telomeric repeat-binding factor TERF1 protein taxon:9823 20221109 UniProt UniProtKB:A0A286ZMS0
UniProtKB A0A287AD45 HPRT1 involved_in GO:0051289 GO_REF:0000107 IEA UniProtKB:P00492|ensembl:ENSP00000298556 P Hypoxanthine phosphoribosyltransferase HPRT1 protein taxon:9823 20221109 Ensembl UniProtKB:A0A287AD45
UniProtKB A0A287AF49 SHKBP1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein SHKBP1 protein taxon:9823 20221109 InterPro UniProtKB:A0A287AF49
UniProtKB A0A287AG83 KCNC2 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC2 protein taxon:9823 20221109 InterPro UniProtKB:A0A287AG83
UniProtKB A0A287AHV8 PTH1R enables GO:0042803 GO_REF:0000107 IEA UniProtKB:Q03431|ensembl:ENSP00000402723 F Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R protein taxon:9823 20221109 Ensembl UniProtKB:A0A287AHV8
UniProtKB A0A287AHV8 PTH1R enables GO:0043621 GO_REF:0000107 IEA UniProtKB:Q03431|ensembl:ENSP00000402723 F Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R protein taxon:9823 20221109 Ensembl UniProtKB:A0A287AHV8
UniProtKB A0A287AS01 USP16 involved_in GO:0051289 GO_REF:0000104 IEA UniRule:UR000160894 P Ubiquitin carboxyl-terminal hydrolase 16 USP16 protein taxon:9823 20221109 UniProt UniProtKB:A0A287AS01
UniProtKB A0A287ATB5 KCTD15 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD15 protein taxon:9823 20221109 InterPro UniProtKB:A0A287ATB5
UniProtKB A0A287ATJ4 CRYAB enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P02511|ensembl:ENSP00000499082 F Alpha-crystallin B chain CRYAB protein taxon:9823 20221109 Ensembl UniProtKB:A0A287ATJ4
UniProtKB A0A287AWS9 HMOX1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P09601|ensembl:ENSP00000216117 F Heme oxygenase HMOX1 protein taxon:9823 20221109 Ensembl UniProtKB:A0A287AWS9
UniProtKB A0A287BDV9 GPD1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1 protein taxon:9823 20221109 InterPro UniProtKB:A0A287BDV9
UniProtKB A0A287BGK9 KCTD7 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD7 protein taxon:9823 20221109 InterPro UniProtKB:A0A287BGK9
UniProtKB A0A287BM03 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9823 20221109 InterPro UniProtKB:A0A287BM03
UniProtKB A0A287BP60 ZNF639 enables GO:0043621 GO_REF:0000107 IEA UniProtKB:Q9UID6|ensembl:ENSP00000417740 F Zinc finger protein 639 ZNF639 protein taxon:9823 20221109 Ensembl UniProtKB:A0A287BP60
UniProtKB A0A2C9F391 PRNP involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR000817|InterPro:IPR022416|InterPro:IPR036924 P Major prion protein PRNP protein taxon:9823 20221109 InterPro UniProtKB:A0A2C9F391
UniProtKB A0A480J073 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9823 20221109 InterPro UniProtKB:A0A480J073
UniProtKB A0A480KZG7 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9823 20221109 InterPro UniProtKB:A0A480KZG7
UniProtKB A0A480WPU1 ENO1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P06733|ensembl:ENSP00000234590 F phosphopyruvate hydratase ENO1 protein taxon:9823 20221109 Ensembl UniProtKB:A0A480WPU1
UniProtKB A0A5G2Q7Q0 ME3 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:Q9ULV1|ensembl:ENSP00000434034 F Frizzled-4 ME3 protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2Q7Q0
UniProtKB A0A5G2QF96 EVL involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR017354 P Ena/VASP-like protein EVL protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2QF96
UniProtKB A0A5G2QGB3 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Junctional adhesion molecule 3 JAM3 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2QGB3
UniProtKB A0A5G2QR31 S100A11 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P31949|ensembl:ENSP00000271638 F Protein S100 S100A11 protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2QR31
UniProtKB A0A5G2QTF2 NADK2 enables GO:0042803 GO_REF:0000104 IEA UniRule:UR000192082 F NAD kinase 2, mitochondrial NADK2 protein taxon:9823 20221109 UniProt UniProtKB:A0A5G2QTF2
UniProtKB A0A5G2QUI8 NADK2 enables GO:0042803 GO_REF:0000104 IEA UniRule:UR000192082 F NAD kinase 2, mitochondrial NADK2 protein taxon:9823 20221109 UniProt UniProtKB:A0A5G2QUI8
UniProtKB A0A5G2QV46 KCTD7 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD7 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2QV46
UniProtKB A0A5G2QX79 CENPF enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR019513 F Centromere protein F CENPF protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2QX79
UniProtKB A0A5G2QY34 CRTC3 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB regulated transcription coactivator 3 CRTC3 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2QY34
UniProtKB A0A5G2R069 CRTC1 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB-regulated transcription coactivator 1 CRTC1 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R069
UniProtKB A0A5G2R0A1 KCTD6 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD6 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R0A1
UniProtKB A0A5G2R242 KCTD17 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD17 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R242
UniProtKB A0A5G2R2L5 CRTC2 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P TORC_C domain-containing protein CRTC2 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R2L5
UniProtKB A0A5G2R8B5 TPD52L1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:Q16890|ensembl:ENSP00000434142 F Tumor protein D53 TPD52L1 protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2R8B5
UniProtKB A0A5G2R947 KCTD7 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD7 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R947
UniProtKB A0A5G2R9M8 KCTD9 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P Potassium channel tetramerization domain containing 9 KCTD9 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2R9M8
UniProtKB A0A5G2R9Y8 GGCT enables GO:0042803 GO_REF:0000107 IEA UniProtKB:O75223|ensembl:ENSP00000275428 F gamma-glutamylcyclotransferase GGCT protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2R9Y8
UniProtKB A0A5G2RAU6 SHKBP1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein SHKBP1 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2RAU6
UniProtKB A0A5G2RDS9 ITGA10 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:O96011|ensembl:ENSP00000358312 F Peroxisomal membrane protein 11B ITGA10|PEX11B protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2RDS9
UniProtKB A0A5G2RFY2 ABCD3 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P28288|ensembl:ENSP00000359233 F ATP-binding cassette sub-family D member 3 ABCD3 protein taxon:9823 20221109 Ensembl UniProtKB:A0A5G2RFY2
UniProtKB A0A5G2RGB1 CRTC3 involved_in GO:0051289 GO_REF:0000002 IEA InterPro:IPR024783 P CREB regulated transcription coactivator 3 CRTC3 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2RGB1
UniProtKB A0A5G2RGP3 KCTD1 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD1 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2RGP3
UniProtKB A0A5G2RI43 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Junctional adhesion molecule 3 JAM3 protein taxon:9823 20221109 InterPro UniProtKB:A0A5G2RI43
UniProtKB A5A757 IKBKB enables GO:0042803 GO_REF:0000107 IEA UniProtKB:O14920|ensembl:ENSP00000430684 F IkappaB kinase IKBKB protein taxon:9823 20221109 Ensembl UniProtKB:A5A757
UniProtKB F1RH35 KCNC3 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC3 protein taxon:9823 20221109 InterPro UniProtKB:F1RH35
UniProtKB F1RKH4 HSPB8 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR043254 F Heat shock protein beta-8 HSPB8 protein taxon:9823 20221109 InterPro UniProtKB:F1RKH4
UniProtKB F1S5Q6 FLT4 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P35916|ensembl:ENSP00000261937 F Vascular endothelial growth factor receptor 3 FLT4 protein taxon:9823 20221109 Ensembl UniProtKB:F1S5Q6
UniProtKB F1S6C7 JAM3 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR042974 F Junctional adhesion molecule 3 JAM3 protein taxon:9823 20221109 InterPro UniProtKB:F1S6C7
UniProtKB F1S7C8 GSTA4 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:O15217|ensembl:ENSP00000360002 F glutathione transferase GSTA4 protein taxon:9823 20221109 Ensembl UniProtKB:F1S7C8
UniProtKB F1SC98 IDE enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P14735|ensembl:ENSP00000265986 F Insulin-degrading enzyme IDE protein taxon:9823 20221109 Ensembl UniProtKB:F1SC98
UniProtKB F1SE53 KIT enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P10721|ensembl:ENSP00000288135 F Mast/stem cell growth factor receptor KIT protein taxon:9823 20221109 Ensembl UniProtKB:F1SE53
UniProtKB F1SH18 KCNC2 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCNC2 protein taxon:9823 20221109 InterPro UniProtKB:F1SH18
UniProtKB F1SHA2 GPD1 enables GO:0042803 GO_REF:0000002 IEA InterPro:IPR017751 F Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD1 protein taxon:9823 20221109 InterPro UniProtKB:F1SHA2
UniProtKB F1SMJ6 C9 involved_in GO:0051260 GO_REF:0000107 IEA UniProtKB:P02748|ensembl:ENSP00000263408 P Complement component C9 C9 protein taxon:9823 20221109 Ensembl UniProtKB:F1SMJ6
UniProtKB F1SNB7 NADK2 enables GO:0042803 GO_REF:0000104 IEA UniRule:UR000192082 F NAD kinase 2, mitochondrial NADK2 protein taxon:9823 20221109 UniProt UniProtKB:F1SNB7
UniProtKB F1SU87 MICU1 involved_in GO:0051260 GO_REF:0000107 IEA UniProtKB:Q9BPX6|ensembl:ENSP00000354415 P Calcium uptake protein 1, mitochondrial MICU1 protein taxon:9823 20221109 Ensembl UniProtKB:F1SU87
UniProtKB F1SUH5 KCTD5 involved_in GO:0051260 GO_REF:0000002 IEA InterPro:IPR003131 P BTB domain-containing protein KCTD5 protein taxon:9823 20221109 InterPro UniProtKB:F1SUH5
UniProtKB I3LKS9 NRF1 enables GO:0042803 GO_REF:0000024 ISS UniProtKB:Q90979 F Nrf1_DNA-bind domain-containing protein NRF1 protein taxon:9823 20150422 AgBase UniProtKB:I3LKS9
UniProtKB I3LM99 GCA enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P28676|ensembl:ENSP00000394842 F EF-hand domain-containing protein GCA protein taxon:9823 20221109 Ensembl UniProtKB:I3LM99
UniProtKB I3LQN4 PHB2 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:Q99623|ensembl:ENSP00000441875 F Prohibitin PHB2 protein taxon:9823 20221109 Ensembl UniProtKB:I3LQN4
UniProtKB P04366 AMBP enables GO:0042803 GO_REF:0000024 ISS UniProtKB:P02760:PRO_0000017886 F Protein AMBP AMBP|ITIL protein taxon:9823 20210819 UniProt UniProtKB:P04366:PRO_0000017895
UniProtKB Q1HDU1 ANG1 enables GO:0042803 GO_REF:0000107 IEA UniProtKB:P03950|ensembl:ENSP00000381077 F RNAse_Pc domain-containing protein ANG1|ANG protein taxon:9823 20221109 Ensembl UniProtKB:Q1HDU1
Annotations to ISS, ISA and ISO should not be self-referential
References should have only one ID per ID space
Group specific filter rules should be applied to annotations
Object extensions should conform to the extensions-patterns.yaml file in metadata
Allowed gene product to term relations (gp2term)