format-version: 1.2 data-version: go/releases/2024-03-08/imports/cl_import.owl ontology: go/imports/cl_import [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [] is_a: UBERON:0000061 relationship: RO:0002160 NCBITaxon:131567 [Term] id: CL:0000005 name: fibroblast neural crest derived def: "Any fibroblast that is deriived from the neural crest." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 [Term] id: CL:0000007 name: early embryonic cell (metazoa) def: "A cell found in the embryo before the formation of all the gem layers is complete." [] is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell def: "A stem cell that is the precursor of gametes." [] synonym: "germline stem cell" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0017145 [Term] id: CL:0000015 name: male germ cell def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." [] is_a: CL:0000586 ! germ cell relationship: RO:0002216 GO:0007283 [Term] id: CL:0000016 name: male germ line stem cell def: "A stem cell that is the precursor of male gametes." [] is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [] is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0002215 GO:0048137 relationship: RO:0002202 CL:0000020 ! spermatogonium [Term] id: CL:0000018 name: spermatid def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [] synonym: "nematoblast" EXACT [] is_a: CL:0000015 ! male germ cell is_a: CL:0000413 ! haploid cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001375 intersection_of: RO:0002215 GO:0001675 intersection_of: RO:0002215 GO:0007288 intersection_of: RO:0002215 GO:0007289 relationship: RO:0002202 CL:0000657 ! secondary spermatocyte [Term] id: CL:0000019 name: sperm def: "A mature male germ cell that develops from a spermatid." [] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] is_a: CL:0000408 ! male gamete relationship: RO:0002202 CL:0000018 ! spermatid [Term] id: CL:0000020 name: spermatogonium def: "An euploid male germ cell of an early stage of spermatogenesis." [] synonym: "spermatogonial cell" EXACT [] is_a: CL:0000015 ! male germ cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001394 intersection_of: RO:0000053 PATO:0001501 [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [] is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 [Term] id: CL:0000022 name: female germ line stem cell def: "A stem cell that is the precursor of female gametes." [] is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0017145 [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [] synonym: "oogonium" RELATED [] is_a: CL:0000021 ! female germ cell relationship: RO:0000056 GO:0007143 relationship: RO:0002160 NCBITaxon:33208 [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [] is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0000278 relationship: RO:0002202 CL:0000670 ! primordial germ cell [Term] id: CL:0000025 name: egg cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] is_a: CL:0000675 ! female gamete relationship: RO:0000056 GO:0007143 relationship: RO:0002202 CL:0000023 ! oocyte [Term] id: CL:0000026 name: invertebrate nurse cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [] synonym: "nurse cell" RELATED [] is_a: CL:0000412 ! polyploid cell is_a: CL:4029002 ! germline-derived nurse cell relationship: RO:0002202 CL:0000722 ! cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived def: "A smooth muscle cell derived from the neural crest." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron synonym: "neuron neural crest derived" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell relationship: RO:0002202 CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast is_a: CL:0000055 ! non-terminally differentiated cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) def: "A cell that will develop into a neuron often after a migration phase." [] synonym: "neuroblast" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell relationship: RO:0002160 NCBITaxon:7742 [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [] synonym: "animal stem cell" EXACT [] is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0017145 relationship: RO:0002162 NCBITaxon:33208 relationship: RO:0002215 GO:0030154 [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001400 intersection_of: RO:0002215 GO:0017145 [Term] id: CL:0000036 name: epithelial fate stem cell synonym: "epithelial stem cell" EXACT [] is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [] synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" RELATED [] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002215 GO:0002244 intersection_of: RO:0002215 GO:0048103 relationship: RO:0002202 CL:0000566 ! angioblastic mesenchymal cell [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [] is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0022414 [Term] id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [] synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 intersection_of: BFO:0000051 GO:0005730 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002215 GO:0030224 relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0000042 name: neutrophilic myeloblast def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [] synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000010799 intersection_of: BFO:0000051 PR:000014362 intersection_of: RO:0002215 GO:0030223 relationship: RO:0002202 CL:0000834 ! neutrophil progenitor cell [Term] id: CL:0000043 name: mature basophil def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [] synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000767 ! basophil is_a: CL:0002274 ! histamine secreting cell relationship: RO:0002202 CL:0000770 ! band form basophil [Term] id: CL:0000047 name: neural stem cell def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." [] synonym: "neuronal stem cell" EXACT [] synonym: "NSC" EXACT [] is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001402 intersection_of: RO:0002215 GO:0017145 [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [] synonym: "CFU-GEMM" RELATED [] synonym: "CFU-S" RELATED [] synonym: "CMP" RELATED [] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [] synonym: "myeloid stem cell" RELATED [] synonym: "pluripotent stem cell (bone marrow)" RELATED [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [] synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030218 intersection_of: RO:0002215 GO:0030219 disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000051 name: common lymphoid progenitor def: "A oligopotent progenitor cell committed to the lymphoid lineage." [] synonym: "CLP" RELATED [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 [Term] id: CL:0000055 name: non-terminally differentiated cell def: "A precursor cell with a limited number of potential fates." [] synonym: "blast cell" EXACT [] is_a: CL:0011115 ! precursor cell relationship: RO:0002215 GO:0030154 [Term] id: CL:0000056 name: myoblast def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [] is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [] is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000058 name: chondroblast def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [] synonym: "chrondoplast" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0007009 ! prechondroblast relationship: RO:0003000 UBERON:0002418 [Term] id: CL:0000059 name: ameloblast def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [] synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0005176 relationship: RO:0002202 CL:0007000 ! preameloblast relationship: RO:0002215 GO:0097186 relationship: RO:0002220 UBERON:0001763 relationship: RO:0003000 UBERON:0001752 [Term] id: CL:0000060 name: odontoblast def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002148 ! dental pulp cell relationship: BFO:0000050 UBERON:0005176 relationship: RO:0002202 CL:0007003 ! preodontoblast relationship: RO:0003000 UBERON:0001751 [Term] id: CL:0000062 name: osteoblast def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0007010 ! preosteoblast relationship: RO:0003000 UBERON:0008883 [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000051 GO:0005929 [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [] synonym: "epitheliocyte" EXACT [] is_a: CL:0000000 ! cell disjoint_from: CL:0000738 ! leukocyte relationship: BFO:0000050 UBERON:0000483 [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cilia." [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0005929 [Term] id: CL:0000068 name: duct epithelial cell def: "An epithelial cell that is part of a duct." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000058 [Term] id: CL:0000069 name: branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell def: "An endothelial cell that lines the vasculature." [] synonym: "cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0004638 relationship: RO:0002202 CL:0002546 ! embryonic blood vessel endothelial progenitor cell [Term] id: CL:0000072 name: non-branched duct epithelial cell is_a: CL:0000068 ! duct epithelial cell is_a: CL:0002078 ! meso-epithelial cell relationship: RO:0002202 CL:0000222 ! mesodermal cell [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000076 name: squamous epithelial cell is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [] synonym: "mesotheliocyte" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: RO:0002202 CL:0000222 ! mesodermal cell [Term] id: CL:0000079 name: stratified epithelial cell is_a: CL:0000066 ! epithelial cell relationship: RO:0002202 CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [] is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 [Term] id: CL:0000082 name: epithelial cell of lung def: "An epithelial cell of the lung." [] synonym: "lung epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002048 relationship: BFO:0000050 UBERON:0000115 [Term] id: CL:0000083 name: epithelial cell of pancreas def: "An epithelial cell of the pancreas." [] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001264 relationship: RO:0002202 CL:0000223 ! endodermal cell [Term] id: CL:0000084 name: T cell def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: RO:0002202 CL:0000827 ! pro-T cell [Term] id: CL:0000092 name: osteoclast def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [] synonym: "chondroclast" RELATED [] is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0001035 ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000050 UBERON:0001474 intersection_of: BFO:0000051 PR:000001850 intersection_of: BFO:0000051 PR:000001937 intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000007597 intersection_of: BFO:0000051 PR:000011178 intersection_of: RO:0002104 PR:000001954 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0002215 GO:0045453 relationship: RO:0002202 CL:0000576 ! monocyte [Term] id: CL:0000094 name: granulocyte def: "A leukocyte with abundant granules in the cytoplasm." [] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000051 GO:0030141 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001332 intersection_of: RO:0002104 PR:000001969 intersection_of: RO:0002215 GO:0008015 [Term] id: CL:0000095 name: neuron associated cell is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [] synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000775 ! neutrophil [Term] id: CL:0000097 name: mast cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [] synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [] synonym: "mastocyte" EXACT [] synonym: "tissue basophil" RELATED [] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000051 GO:0030141 intersection_of: lacks_plasma_membrane_part PR:000001865 intersection_of: RO:0002104 PR:000001255 intersection_of: RO:0002104 PR:000006169 intersection_of: RO:0002215 GO:0002349 intersection_of: RO:0002215 GO:0002539 intersection_of: RO:0002215 GO:0002660 intersection_of: RO:0002215 GO:0002690 intersection_of: RO:0002215 GO:0002830 intersection_of: RO:0002215 GO:0030210 intersection_of: RO:0015015 PR:000002065 intersection_of: RO:0015015 PR:000007431 relationship: RO:0002202 CL:0000831 ! mast cell progenitor [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [] synonym: "neuroepithelial cell" BROAD [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050906 [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [] is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [] synonym: "motoneuron" EXACT [] is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [] is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 [Term] id: CL:0000103 name: bipolar neuron def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [] is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070006 [Term] id: CL:0000106 name: unipolar neuron def: "Neuron with one neurite that extends from the cell body." [] is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron def: "A neuron whose cell body is within an autonomic ganglion." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0014055 [Term] id: CL:0000113 name: mononuclear phagocyte def: "A vertebrate phagocyte with a single nucleus." [] is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001407 [Term] id: CL:0000114 name: surface ectodermal cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [] synonym: "endotheliocyte" EXACT [] is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) is_a: CL:0000540 ! neuron relationship: BFO:0000050 UBERON:0001017 relationship: RO:0002202 CL:0000031 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000119 name: cerebellar Golgi cell def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [] synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron relationship: RO:0002100 UBERON:0002129 [Term] id: CL:0000120 name: granule cell def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell def: "The output neuron of the cerebellar cortex." [] synonym: "cerebellar Purkinje cell" EXACT [] synonym: "cerebellum Purkinje cell" EXACT [] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron relationship: RO:0002100 UBERON:0002129 [Term] id: CL:0000122 name: stellate neuron def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0000053 PATO:0070010 [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) is_a: CL:0000095 ! neuron associated cell relationship: RO:0002160 NCBITaxon:7742 relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000126 name: macroglial cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [] synonym: "macroglia" RELATED [] synonym: "macrogliocyte" EXACT [] is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [] synonym: "astrocytic glia" EXACT [] is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [] synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [] is_a: CL:0000126 ! macroglial cell is_a: CL:4023154 ! myelinating glial cell relationship: BFO:0000050 UBERON:0001017 relationship: BFO:0000051 GO:0043209 relationship: RO:0002202 CL:0002453 ! oligodendrocyte precursor cell [Term] id: CL:0000129 name: microglial cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [] synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" RELATED [] synonym: "microgliocyte" EXACT [] is_a: CL:0000125 ! glial cell is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0001017 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001813 intersection_of: RO:0002104 PR:000002064 intersection_of: RO:0002215 GO:0045087 relationship: RO:0002202 CL:0000222 ! mesodermal cell [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [] synonym: "BMSC" RELATED [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED [] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED [] synonym: "MSC" RELATED [] synonym: "stem cells, mesenchymal" RELATED [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000135 name: fibrocyte def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: RO:0002215 GO:0002495 intersection_of: RO:0002215 GO:0045766 relationship: RO:0002202 CL:0000057 ! fibroblast [Term] id: CL:0000136 name: adipocyte def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [] synonym: "adipose cell" EXACT [] synonym: "fat cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000138 name: chondrocyte def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [] synonym: "cartilage cell" EXACT [] is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: RO:0001025 UBERON:0002418 relationship: RO:0002202 CL:0000058 ! chondroblast [Term] id: CL:0000145 name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [] synonym: "APC" RELATED [] is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002215 GO:0002504 [Term] id: CL:0000146 name: simple columnar epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000148 name: melanocyte def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [] synonym: "melanophore" NARROW [] is_a: CL:0000147 ! pigment cell intersection_of: CL:0000147 ! pigment cell intersection_of: BFO:0000051 GO:0042470 intersection_of: RO:0002202 CL:0000541 ! melanoblast [Term] id: CL:0000149 name: visual pigment cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0006799 [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0032940 [Term] id: CL:0000153 name: glycosaminoglycan secreting cell def: "A cell that secretes glycosaminoglycans." [] synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 [Term] id: CL:0000157 name: surfactant secreting cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 [Term] id: CL:0000158 name: club cell def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." [] synonym: "Clara cell" EXACT [] is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0011026 ! progenitor cell relationship: RO:0002104 GO:0005902 relationship: RO:0002215 GO:0032940 relationship: RO:0002215 GO:0043129 [Term] id: CL:0000159 name: seromucus secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell def: "A cell of the epithelial lining that produce and secrete mucins." [] synonym: "chalice cell" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: RO:0002215 GO:0070254 [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [] synonym: "endocrinocyte" EXACT [] is_a: CL:0000000 ! cell is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="BFO:0000050"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="BFO:0000050"} ! enteroendocrine cell is_a: CL:0000164 {gci_filler="UBERON:0000945", gci_relation="BFO:0000050"} ! enteroendocrine cell relationship: BFO:0000050 UBERON:0000949 [Term] id: CL:0000164 name: enteroendocrine cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [] synonym: "neurosecretory cell" RELATED [] synonym: "neurosecretory neuron" RELATED [] is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0046879 [Term] id: CL:0000166 name: chromaffin cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [] synonym: "phaeochromocyte" EXACT [] is_a: CL:0000029 ! neural crest derived neuron is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 [Term] id: CL:0000168 name: insulin secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030073 [Term] id: CL:0000169 name: type B pancreatic cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [] synonym: "B-cell of pancreatic islet" EXACT [] synonym: "beta cell" BROAD [] synonym: "beta cell islet" RELATED [] synonym: "beta cell of pancreatic islet" EXACT [] synonym: "insulin-secreting cell" EXACT [] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [] synonym: "pancreatic beta cell" EXACT [] synonym: "pancreatic islet core" EXACT [] synonym: "type B enteroendocrine cell" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000168 ! insulin secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000006 intersection_of: RO:0002215 GO:0030073 relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000170 name: glucagon secreting cell def: "A cell that secretes glucagon." [] synonym: "glucagon-secreting cell" EXACT [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 [Term] id: CL:0000171 name: pancreatic A cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [] synonym: "alpha cell of islet of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001264 relationship: BFO:0000050 UBERON:0000006 relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas relationship: RO:0002215 GO:0070091 [Term] id: CL:0000172 name: somatostatin secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 [Term] id: CL:0000173 name: pancreatic D cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001264 relationship: BFO:0000050 UBERON:0000006 relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000174 name: steroid hormone secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 [Term] id: CL:0000175 name: luteal cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [] synonym: "corpus luteum cell" EXACT [] synonym: "lutein cell" EXACT [] is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0000179 ! progesterone secreting cell is_a: CL:0002132 ! stromal cell of ovary relationship: BFO:0000050 UBERON:0002512 relationship: RO:0002215 GO:0042701 [Term] id: CL:0000176 name: ecdysteroid secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045457 [Term] id: CL:0000177 name: testosterone secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035936 [Term] id: CL:0000178 name: Leydig cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [] synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] is_a: CL:0000177 ! testosterone secreting cell relationship: BFO:0000050 UBERON:0005212 relationship: RO:0002202 CL:0009091 ! Leydig stem cell [Term] id: CL:0000179 name: progesterone secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0042701 [Term] id: CL:0000180 name: estradiol secreting cell def: "A steroid hormone secreting cell that secretes estradiol." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035938 [Term] id: CL:0000182 name: hepatocyte def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000417 ! endopolyploid cell relationship: BFO:0000050 UBERON:0002107 relationship: RO:0002202 CL:0005026 ! hepatoblast relationship: RO:0002215 GO:0006699 relationship: RO:0002215 GO:0044237 relationship: RO:0002215 GO:0098754 [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [] is_a: CL:0000000 ! cell [Term] id: CL:0000186 name: myofibroblast cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [] synonym: "MFB" EXACT [] is_a: CL:0000183 ! contractile cell is_a: CL:0002320 ! connective tissue cell relationship: BFO:0000050 UBERON:0002384 [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell relationship: RO:0002202 CL:0000056 ! myoblast [Term] id: CL:0000188 name: cell of skeletal muscle def: "A somatic cell located in skeletal muscle." [] synonym: "skeletal muscle cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001134 [Term] id: CL:0000189 name: slow muscle cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [] synonym: "slow muscle fiber" RELATED [] is_a: CL:0008046 ! extrafusal muscle fiber relationship: RO:0002202 CL:0000857 ! slow muscle myoblast [Term] id: CL:0000192 name: smooth muscle cell def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [] synonym: "myocytes, smooth muscle" EXACT [] synonym: "non-striated muscle cell" BROAD [] synonym: "SMCs" EXACT [] synonym: "smooth muscle fiber" EXACT [] is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: RO:0002202 CL:0000514 ! smooth muscle myoblast [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] synonym: "receptor cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001032 intersection_of: RO:0002215 GO:0050906 [Term] id: CL:0000199 name: mechanoreceptor cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [] synonym: "mechanoreceptor" RELATED [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050974 [Term] id: CL:0000200 name: touch receptor cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050976 [Term] id: CL:0000202 name: auditory hair cell def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [] synonym: "auditory receptor cell" RELATED [] is_a: CL:0000855 ! sensory hair cell relationship: RO:0002215 GO:0050910 [Term] id: CL:0000203 name: gravity sensitive cell is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0070999 [Term] id: CL:0000205 name: thermoreceptor cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0050960 [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [] is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: RO:0002215 GO:0050907 [Term] id: CL:0000207 name: olfactory receptor cell synonym: "odorant receptor cell" EXACT [] synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050911 relationship: BFO:0000050 UBERON:0005725 [Term] id: CL:0000209 name: taste receptor cell def: "A specialized cell involved in gustatory sensory perception." [] synonym: "taste bud cell" EXACT [] is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000206 ! chemoreceptor cell intersection_of: RO:0002215 GO:0050912 [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized to detect and transduce light." [] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050962 [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [] is_a: CL:0000000 ! cell [Term] id: CL:0000213 name: lining cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] synonym: "synoviocyte" EXACT [] is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0002217 [Term] id: CL:0000215 name: barrier cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [] is_a: CL:0000000 ! cell [Term] id: CL:0000216 name: Sertoli cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [] is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 ! supporting cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000630 ! supporting cell intersection_of: BFO:0000050 UBERON:0001343 [Term] id: CL:0000217 name: insulating cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] is_a: CL:0000217 ! insulating cell is_a: CL:0002573 ! Schwann cell is_a: CL:4023154 ! myelinating glial cell relationship: BFO:0000051 GO:0043209 relationship: RO:0002202 CL:0002377 ! immature Schwann cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0048870 [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [] synonym: "ectoderm cell" EXACT [] is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000924 [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000926 [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [] synonym: "endoderm cell" EXACT [] is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000925 [Term] id: CL:0000225 name: anucleate cell def: "A cell that lacks a nucleus." [] synonym: "non-nucleated cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001405 disjoint_from: CL:0002242 ! nucleate cell [Term] id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001407 [Term] id: CL:0000227 name: binucleate cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001406 [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: lacks_part GO:0005840 intersection_of: lacks_plasma_membrane_part PR:000001945 intersection_of: RO:0000053 PATO:0002039 intersection_of: RO:0002215 GO:0008015 intersection_of: RO:0002215 GO:0015671 relationship: RO:0002202 CL:0000558 ! reticulocyte [Term] id: CL:0000233 name: platelet def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [] synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000763 ! myeloid cell relationship: RO:0000053 PATO:0001405 relationship: RO:0000053 PATO:0001874 relationship: RO:0002202 CL:0000556 ! megakaryocyte relationship: RO:0002215 GO:0001820 relationship: RO:0002216 GO:0007596 [Term] id: CL:0000234 name: phagocyte def: "Any cell capable of ingesting particulate matter via phagocytosis." [] is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0006909 [Term] id: CL:0000235 name: macrophage def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] synonym: "histiocyte" EXACT [] is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0002215 GO:0002504 intersection_of: RO:0002215 GO:0006909 intersection_of: RO:0002215 GO:0031268 relationship: RO:0002202 CL:0000576 ! monocyte [Term] id: CL:0000236 name: B cell def: "A lymphocyte of B lineage that is capable of B cell mediated immunity." [] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] is_a: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0002215 GO:0019724 relationship: RO:0002202 CL:0000826 ! pro-B cell [Term] id: CL:0000237 name: keratinizing barrier epithelial cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell is_a: CL:0002077 ! ecto-epithelial cell relationship: RO:0002202 CL:0000114 ! surface ectodermal cell [Term] id: CL:0000239 name: brush border epithelial cell is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: BFO:0000051 GO:0005929 [Term] id: CL:0000240 name: stratified squamous epithelial cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000244 name: transitional epithelial cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000247 name: Rohon-Beard neuron def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [] synonym: "RB neuron" RELATED [] synonym: "Rohon Beard cell" EXACT [] synonym: "Rohon-Beard cell" EXACT [] is_a: CL:0000531 ! primary sensory neuron (sensu Teleostei) is_a: CL:4023168 ! somatosensory neuron [Term] id: CL:0000253 name: eurydendroid cell is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000255 name: eukaryotic cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:2759 disjoint_from: CL:0000520 ! prokaryotic cell [Term] id: CL:0000287 name: eye photoreceptor cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000970 [Term] id: CL:0000295 name: somatotropin secreting cell def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030252 [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0000053 PATO:0001375 intersection_of: RO:0002215 GO:0009566 [Term] id: CL:0000301 name: pole cell def: "A primordial germ cell of insects. Such cells form at the posterior pole of the early embryo." [] is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000306 name: crystallin accumulating cell synonym: "lens cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [] synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: BFO:0000050 UBERON:0001003 relationship: RO:0002215 GO:0002775 relationship: RO:0002215 GO:0002776 relationship: RO:0002215 GO:0090023 [Term] id: CL:0000314 name: milk secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000317 name: sebum secreting cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [] synonym: "sebocyte" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:2000021 ! sebaceous gland cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0001821 [Term] id: CL:0000319 name: mucus secreting cell synonym: "mucous cell" EXACT [] is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070254 relationship: RO:0002215 GO:0070254 [Term] id: CL:0000322 name: pneumocyte def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [] synonym: "alveolar epithelial cell" EXACT [] synonym: "pneumonocyte" EXACT [] is_a: CL:0000066 ! epithelial cell relationship: BFO:0000050 UBERON:0004821 [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [] is_a: CL:0000000 ! cell [Term] id: CL:0000327 name: extracellular matrix secreting cell is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0015671 [Term] id: CL:0000333 name: migratory neural crest cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [] is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) def: "A neural precursor of the central nervous system." [] synonym: "neuroblast" BROAD [] is_a: CL:0000047 ! neural stem cell relationship: RO:0002160 NCBITaxon:33317 [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) def: "An early neural cell developing from the early ependymal cell of the neural tube." [] synonym: "spongioblast" EXACT [] is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: RO:0002160 NCBITaxon:7742 [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) is_a: CL:0000147 ! pigment cell [Term] id: CL:0000349 name: extraembryonic cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000478 [Term] id: CL:0000350 name: amnioserosal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: BFO:0000050 UBERON:0010302 [Term] id: CL:0000351 name: trophoblast cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [] synonym: "trophoblastic cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell relationship: BFO:0000050 UBERON:0000358 [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0001134 [Term] id: CL:0000357 name: stratified epithelial stem cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000359 name: vascular associated smooth muscle cell def: "A smooth muscle cell associated with the vasculature." [] synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002049 [Term] id: CL:0000362 name: epidermal cell def: "An epithelial cell of the integument (the outer layer of an organism)." [] synonym: "cell of epidermis" EXACT [] synonym: "epithelial cell of skin" NARROW [] is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007376 [Term] id: CL:0000365 name: animal zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [] synonym: "zygote" BROAD [] is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: RO:0002160 NCBITaxon:33208 [Term] id: CL:0000373 name: histoblast def: "A progenitor cell found in the larval epidermis of insects and that gives rise to the adult abdominal epidermis." [] is_a: CL:0011026 ! progenitor cell relationship: RO:0002160 NCBITaxon:50557 [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) def: "A precursor of mature hemocytes." [] is_a: CL:0008001 ! hematopoietic precursor cell [Term] id: CL:0000386 name: attachment cell is_a: CL:0000630 ! supporting cell [Term] id: CL:0000387 name: hemocyte (sensu Arthropoda) def: "A blood cell of the circulatory system of arthropods." [] is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) relationship: RO:0002160 NCBITaxon:6656 relationship: RO:0002202 CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000388 name: tendon cell def: "An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance." [] synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:0000135 ! fibrocyte is_a: CL:0000386 ! attachment cell intersection_of: CL:0000135 ! fibrocyte intersection_of: BFO:0000050 UBERON:0000043 [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) is_a: CL:0000081 ! blood cell [Term] id: CL:0000392 name: crystal cell def: "A hemocyte that synthesizes and secretes melanins as part of the antimicrobial immune response. It is characterized morphologically by crystal inclusions of phenoloxidases in its cytoplasm, hence its name." [] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) relationship: RO:0002202 CL:0000395 ! procrystal cell [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte def: "A phagocytic hemocyte, responsible for the engulfment of small particles, microbes, and apoptotic tissue debris. It may also secretes antimicrobial peptides and contribute to the production and secretion of proteins of the hemolymph." [] synonym: "macrophage" RELATED [] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) relationship: RO:0002215 GO:0035010 [Term] id: CL:0000395 name: procrystal cell def: "A precursor of mature crystal cells." [] is_a: CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte def: "A hemocyte found in immuno-stimulated larvae." [] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0000397 name: ganglion interneuron is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 [Term] id: CL:0000402 name: CNS interneuron def: "An interneuron that has its cell body in a central nervous system." [] is_a: CL:0000099 ! interneuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0001017 [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000408 name: male gamete is_a: CL:0000015 ! male germ cell is_a: CL:0000300 ! gamete intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0000053 PATO:0001375 intersection_of: RO:0002215 GO:0009566 [Term] id: CL:0000412 name: polyploid cell def: "A cell that contains more than two haploid sets of chromosomes." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001377 [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 [Term] id: CL:0000417 name: endopolyploid cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000422 name: mitogenic signaling cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [] is_a: CL:0000000 ! cell [Term] id: CL:0000423 name: tip cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000430 name: xanthophore cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [] synonym: "xanthophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: RO:0002202 CL:0005002 ! xanthoblast [Term] id: CL:0000431 name: iridophore def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [] synonym: "guanophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: RO:0002202 CL:0005001 ! iridoblast [Term] id: CL:0000438 name: luteinizing hormone secreting cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0032275 [Term] id: CL:0000439 name: prolactin secreting cell def: "A peptide hormone cell that secretes prolactin." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070459 [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036160 [Term] id: CL:0000441 name: follicle stem cell (sensu Arthropoda) def: "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods." [] synonym: "somatic stem cell" BROAD [] is_a: CL:0000036 ! epithelial fate stem cell relationship: RO:0002160 NCBITaxon:6656 [Term] id: CL:0000442 name: follicular dendritic cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [] is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036161 [Term] id: CL:0000447 name: carbohydrate secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white adipocyte def: "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" RELATED [] is_a: CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0001347 relationship: RO:0002202 CL:0002334 ! preadipocyte [Term] id: CL:0000449 name: brown adipocyte def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [] synonym: "brown adipose cell" EXACT [] synonym: "brown fat cell" EXACT [] is_a: CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0001348 relationship: RO:0002202 CL:0002335 ! brown preadipocyte [Term] id: CL:0000451 name: dendritic cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 GO:0042613 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: RO:0000053 PATO:0001407 intersection_of: RO:0002215 GO:0001816 intersection_of: RO:0002215 GO:0002504 intersection_of: RO:0002215 GO:0019882 intersection_of: RO:0002215 GO:0045580 disjoint_from: CL:0000542 ! lymphocyte [Term] id: CL:0000453 name: Langerhans cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [] synonym: "LC" EXACT [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001293 intersection_of: RO:0002215 GO:0002828 relationship: RO:0002202 CL:0000763 ! myeloid cell [Term] id: CL:0000454 name: epinephrine secreting cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [] synonym: "adrenaline secreting cell" EXACT [] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048242 [Term] id: CL:0000456 name: mineralocorticoid secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035931 [Term] id: CL:0000457 name: biogenic amine secreting cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 [Term] id: CL:0000459 name: noradrenergic cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [] synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 [Term] id: CL:0000460 name: glucocorticoid secreting cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035933 [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [] synonym: "ACTH secreting cell" EXACT [] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0051458 [Term] id: CL:0000469 name: ganglion mother cell def: "A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda). The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells." [] is_a: CL:0011020 ! neural progenitor cell relationship: RO:0002202 CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000473 name: defensive cell def: "A cell whose primary function is to protect the organism." [] is_a: CL:0000000 ! cell [Term] id: CL:0000474 name: pericardial nephrocyte def: "An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [] synonym: "pericardial cell" NARROW [] is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000476 name: thyrotroph def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: RO:0002215 GO:0070460 [Term] id: CL:0000477 name: follicle cell of egg chamber def: "A somatic epithelial cell of the insect egg chamber." [] synonym: "follicle cell" BROAD [] synonym: "ovarian follicle cell" BROAD [] is_a: CL:0000500 ! follicular epithelial cell is_a: CL:2000064 ! ovarian surface epithelial cell relationship: BFO:0000050 UBERON:0000992 relationship: RO:0002160 NCBITaxon:50557 relationship: RO:0002202 CL:0000441 ! follicle stem cell (sensu Arthropoda) [Term] id: CL:0000482 name: juvenile hormone secreting cell def: "An endocrine cell that secretes juvenile hormone." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045443 [Term] id: CL:0000484 name: connective tissue type mast cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [] synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: BFO:0000050 UBERON:0002384 [Term] id: CL:0000485 name: mucosal type mast cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [] synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: BFO:0000050 UBERON:0001961 intersection_of: RO:0002215 GO:0002540 [Term] id: CL:0000486 name: garland cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [] synonym: "garland nephrocyte" BROAD [] is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000487 name: oenocyte def: "A secretory cell of ectodermal origin. This cell may have important functions in fatty acid and hydrocarbon metabolism and is metabolically linked to the fat body and tracheae. This cell is exclusive of arthropods." [] is_a: CL:0000151 ! secretory cell relationship: RO:0002160 NCBITaxon:6656 [Term] id: CL:0000488 name: visible light photoreceptor cell def: "A photoreceptor cell that detects visible light." [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 [Term] id: CL:0000492 name: CD4-positive helper T cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001816 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: RO:0002353 GO:0030217 [Term] id: CL:0000494 name: UV sensitive photoreceptor cell def: "A photoreceptor cell that detects ultraviolet light." [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009589 [Term] id: CL:0000498 name: inhibitory interneuron def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [] is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [] is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000500 name: follicular epithelial cell def: "An epithelial somatic cell associated with a maturing oocyte." [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000501 name: granulosa cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [] synonym: "granulosa cell of ovary" EXACT [] is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [] synonym: "D cell" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell relationship: RO:0002215 GO:0070253 [Term] id: CL:0000511 name: androgen binding protein secreting cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [] is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000513 name: cardiac muscle myoblast def: "A precursor cell destined to differentiate into cardiac muscle cell." [] synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001133 intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [] synonym: "myoblast, smooth muscle" EXACT [] synonym: "satellite cell" RELATED [] is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [] synonym: "skeletal myoblast" EXACT [] is_a: CL:0000056 ! myoblast is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008002 ! skeletal muscle fiber relationship: RO:0002202 CL:0000355 ! multi-potent skeletal muscle stem cell [Term] id: CL:0000517 name: macrophage derived foam cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] synonym: "lipophage" EXACT [] is_a: CL:0000891 ! foam cell relationship: RO:0002202 CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) def: "A phagocyte in vertebrates that is able to phagocytosis." [] is_a: CL:0000234 ! phagocyte relationship: RO:0002160 NCBITaxon:7742 [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell is_a: CL:0000000 ! cell [Term] id: CL:0000521 name: fungal cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:4751 [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [] synonym: "plasmidotrophoblast cell" RELATED [] synonym: "syncytial trophoblast cell" EXACT [] synonym: "syncytiotrophoblastic cell" EXACT [] synonym: "syntrophoblast cell" RELATED [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 relationship: BFO:0000050 UBERON:0000371 [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [] synonym: "input neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000530 name: primary neuron (sensu Teleostei) def: "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." [] is_a: CL:0000540 ! neuron relationship: RO:0002160 NCBITaxon:32443 [Term] id: CL:0000531 name: primary sensory neuron (sensu Teleostei) def: "A primary neuron (sensu Teleostei) that has a sensory function." [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron (sensu Teleostei) intersection_of: CL:0000101 ! sensory neuron intersection_of: CL:0000530 ! primary neuron (sensu Teleostei) [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [] synonym: "nerve cell" EXACT [] is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162"} ! neuroblast (sensu Vertebrata) relationship: RO:0002215 GO:0019226 [Term] id: CL:0000541 name: melanoblast def: "A cell that originates from the neural crest and differentiates into a pigment cell." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0000542 name: lymphocyte def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [] is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 CL:0017500 ! neutrophillic cytoplasm intersection_of: BFO:0000051 GO:0000792 intersection_of: RO:0000053 PATO:0001407 intersection_of: RO:0000053 PATO:0040072 disjoint_from: CL:0000766 ! myeloid leukocyte relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000545 name: T-helper 1 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [] synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 CD4+ T cell" EXACT [] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000001835 intersection_of: lacks_plasma_membrane_part PR:000001202 intersection_of: RO:0002104 PR:000001207 intersection_of: RO:0002215 GO:0032609 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000546 name: T-helper 2 cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [] synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000001941 intersection_of: lacks_plasma_membrane_part PR:000001202 intersection_of: lacks_plasma_membrane_part PR:000001207 intersection_of: RO:0002215 GO:0032633 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [] is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm intersection_of: BFO:0000051 GO:0005730 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: RO:0000053 PATO:0002505 intersection_of: RO:0000053 PATO:0040072 intersection_of: RO:0002104 PR:000001945 relationship: RO:0002202 CL:0000038 ! erythroid progenitor cell [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [] synonym: "basophilic normoblast" EXACT [] synonym: "early erythroblast" EXACT [] synonym: "early normoblast" EXACT [] synonym: "prorubricyte" EXACT [] is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 intersection_of: RO:0002104 PR:000001945 relationship: RO:0002202 CL:0000547 ! proerythroblast [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [] synonym: "intermediate erythroblast" EXACT [] synonym: "intermediate normoblast" EXACT [] synonym: "polychromatic erythroblast" EXACT [] synonym: "polychromatic normoblast" EXACT [] synonym: "polychromatophilic normoblast" EXACT [] synonym: "rubricyte" EXACT [] is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017504 ! polychromatophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 intersection_of: RO:0002104 PR:000001945 relationship: RO:0002202 CL:0000549 ! basophilic erythroblast [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [] synonym: "acidophilic erythroblast" EXACT [] synonym: "eosinophilic erythroblast" EXACT [] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [] synonym: "pyknotic eto enrythroblast" EXACT [] is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017502 ! acidophilic cytoplasm intersection_of: RO:0000056 GO:0030263 relationship: RO:0002202 CL:0000550 ! polychromatophilic erythroblast [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [] synonym: "CFU-Meg" EXACT [] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [] synonym: "MkP" EXACT [] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002215 GO:0007113 intersection_of: RO:0002215 GO:0030219 relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000556 name: megakaryocyte def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [] synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] is_a: CL:0000763 ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: RO:0000053 PATO:0001393 relationship: RO:0002202 CL:0000553 ! megakaryocyte progenitor cell [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [] synonym: "CFU-C , Colony forming unit in culture" BROAD [] synonym: "CFU-GM" RELATED [] synonym: "colony forming unit granulocyte macrophage" EXACT [] synonym: "GMP" RELATED [] synonym: "granulocyte-macrophage progenitor" EXACT [] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: BFO:0000050 UBERON:0002371 intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000005307 intersection_of: lacks_part PR:000007857 intersection_of: lacks_part PR:000007858 intersection_of: RO:0002104 PR:000001865 intersection_of: RO:0002215 GO:0030225 intersection_of: RO:0002215 GO:0030851 relationship: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [] is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: RO:0002104 PR:000001945 intersection_of: RO:0002215 GO:0071971 relationship: RO:0002202 CL:0000552 ! orthochromatic erythroblast [Term] id: CL:0000559 name: promonocyte def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [] is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 GO:0042582 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002215 GO:0030224 relationship: RO:0002202 CL:0000040 ! monoblast [Term] id: CL:0000561 name: amacrine cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [] synonym: "AC" RELATED [] synonym: "ACs" RELATED [] synonym: "amacrine neuron" EXACT [] is_a: CL:0000099 ! interneuron relationship: BFO:0000050 UBERON:0000966 relationship: RO:0002120 CL:0000740 ! retinal ganglion cell relationship: RO:0002162 NCBITaxon:7742 [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0002505 relationship: RO:0002202 CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000563 name: endospore def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [] synonym: "bacterial spore" EXACT [] is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [] synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000010543 intersection_of: BFO:0000051 PR:000014362 intersection_of: lacks_part PR:000009978 intersection_of: RO:0002215 GO:0030223 relationship: RO:0002202 CL:0000042 ! neutrophilic myeloblast [Term] id: CL:0000566 name: angioblastic mesenchymal cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [] synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: RO:0002104 PR:000001444 intersection_of: RO:0002104 PR:000002112 intersection_of: RO:0002104 PR:000016043 relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000568 name: amine precursor uptake and decarboxylation cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [] synonym: "APUD cell" EXACT [] is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [] is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: RO:0002203 CL:0002494 ! cardiocyte [Term] id: CL:0000570 name: parafollicular cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [] synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [] synonym: "clear cell of thyroid gland" EXACT [] synonym: "parafollicular cell of thyroid gland" EXACT [] synonym: "thyroid parafollicular cell" EXACT [] is_a: CL:0000443 ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: RO:0002104 PR:000001024 intersection_of: RO:0002215 GO:0001820 intersection_of: RO:0002215 GO:0014046 intersection_of: RO:0002215 GO:0036161 relationship: BFO:0000050 UBERON:0001747 relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0000571 name: leucophore def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [] is_a: CL:0000147 ! pigment cell relationship: RO:0002202 CL:0005003 ! leucoblast [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [] synonym: "cone" RELATED [] is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell [Term] id: CL:0000574 name: erythrophore def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [] is_a: CL:0000147 ! pigment cell relationship: RO:0002202 CL:0005004 ! pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell def: "An epithelial cell of the cornea." [] synonym: "epithelial cell of cornea" EXACT [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001772 [Term] id: CL:0000576 name: monocyte def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [] is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001407 intersection_of: RO:0002215 GO:0030225 intersection_of: RO:0002215 GO:0030316 intersection_of: RO:0002215 GO:0043011 relationship: RO:0002202 CL:0000559 ! promonocyte [Term] id: CL:0000579 name: border follicle cell def: "A follicle cell that migrates from the anterior pole of the insect egg chamber to the anterior of the oocyte where they participate in the formation of the micropyle." [] is_a: CL:0000477 ! follicle cell of egg chamber [Term] id: CL:0000584 name: enterocyte def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [] synonym: "differentiated enterocyte" NARROW [] synonym: "mature enterocyte" NARROW [] is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [] is_a: CL:0000039 ! germ line cell relationship: RO:0002216 GO:0009566 [Term] id: CL:0000588 name: odontoclast def: "A specialized osteoclast associated with the absorption and removal of cementum." [] is_a: CL:0000092 ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0002215 GO:0042483 [Term] id: CL:0000593 name: androgen secreting cell def: "A steroid hormone secreting cell that secretes androgen." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 [Term] id: CL:0000594 name: skeletal muscle satellite cell def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000680 ! muscle precursor cell relationship: BFO:0000050 UBERON:0001134 [Term] id: CL:0000595 name: enucleate erythrocyte def: "An erythrocyte lacking a nucleus." [] synonym: "RBC" RELATED [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0001405 relationship: RO:0002202 CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000596 name: sexual spore def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [] synonym: "meiotically-derived spore" EXACT [] is_a: CL:0002369 ! fungal spore [Term] id: CL:0000598 name: pyramidal neuron def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [] synonym: "projection neuron" EXACT [] synonym: "pyramidal cell" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070015 [Term] id: CL:0000599 name: conidium def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [] is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000601 name: cochlear outer hair cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [] is_a: CL:4023120 ! cochlea auditory hair cell relationship: BFO:0000050 UBERON:0002227 [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [] synonym: "rod" RELATED [] is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore def: "A spore formed following mitosis or mitoses." [] is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [] is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [] is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [] is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [] synonym: "vestibular receptor cell" EXACT [] is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000611 name: eosinophil progenitor cell synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" RELATED [] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000001865 intersection_of: RO:0002104 PR:000001867 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002215 GO:0030222 relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000612 name: eosinophilic myelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [] is_a: CL:0000772 ! immature eosinophil is_a: CL:0002193 ! myelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 GO:0042582 intersection_of: lacks_part GO:0070820 intersection_of: lacks_plasma_membrane_part PR:000001483 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001456 intersection_of: RO:0002104 PR:000001892 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002031 [Term] id: CL:0000613 name: basophil progenitor cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [] synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000007858 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002215 GO:0030221 intersection_of: RO:0015015 PR:000007431 intersection_of: RO:0015016 PR:000016401 relationship: RO:0002202 CL:0002028 ! basophil mast progenitor cell [Term] id: CL:0000614 name: basophilic myelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [] is_a: CL:0000768 ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 GO:0042582 intersection_of: lacks_part GO:0005730 intersection_of: lacks_part GO:0070820 intersection_of: lacks_plasma_membrane_part PR:000001483 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001456 intersection_of: RO:0002104 PR:000001892 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002031 relationship: RO:0002202 CL:0000830 ! basophilic promyelocyte [Term] id: CL:0000615 name: basidiospore def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [] is_a: CL:0000596 ! sexual spore [Term] id: CL:0000617 name: GABAergic neuron def: "A neuron that uses GABA as a vesicular neurotransmitter" [] synonym: "GABA-ergic neuron" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: BFO:0000050 UBERON:0009842 [Term] id: CL:0000623 name: natural killer cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] is_a: CL:0001067 ! group 1 innate lymphoid cell intersection_of: CL:0001067 ! group 1 innate lymphoid cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: RO:0002215 GO:0002228 intersection_of: RO:0002215 GO:0050776 relationship: RO:0002202 CL:0000825 ! pro-NK cell [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 PR:000001004 disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: RO:0002104 PR:000025402 [Term] id: CL:0000630 name: supporting cell def: "A cell whose primary function is to support other cell types." [] synonym: "supportive cell" EXACT [] is_a: CL:0000000 ! cell [Term] id: CL:0000632 name: hepatic stellate cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [] synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [] is_a: CL:0000057 ! fibroblast is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0002107 intersection_of: RO:0002104 PR:000007939 [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland def: "A cell that stains readily in the anterior pituitary gland." [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002196 relationship: RO:0002215 GO:0030072 [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis def: "A basophilic chromophil cell that of the anterior pituitary gland." [] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000644 name: Bergmann glial cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [] is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [] synonym: "foreign body giant cell" EXACT [] synonym: "Langerhans giant cell" EXACT [] synonym: "macrophage polykaryon" EXACT [] synonym: "multinucleate giant cell" EXACT [] synonym: "syncytial giant cell" EXACT [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001908 intersection_of: RO:0000056 GO:0002432 intersection_of: RO:0000056 GO:0002544 relationship: RO:0002202 CL:0000235 ! macrophage [Term] id: CL:0000648 name: kidney granular cell def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [] synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002113 intersection_of: RO:0002215 GO:0002001 relationship: BFO:0000050 UBERON:0002303 [Term] id: CL:0000650 name: mesangial cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [] synonym: "kidney mesangial cell" EXACT [] is_a: CL:0000669 ! pericyte relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000653 name: podocyte def: "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." [] synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [] synonym: "glomerular podocyte" EXACT [] synonym: "glomerular visceral epithelial cell" EXACT [] synonym: "kidney podocyte" EXACT [] synonym: "renal podocyte" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002522 ! renal filtration cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005751 [Term] id: CL:0000654 name: primary oocyte def: "A primary oocyte is an oocyte that has not completed female meosis I." [] synonym: "primary oogonium" RELATED [] is_a: CL:0000023 ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0051321 relationship: RO:0002202 CL:0000024 ! oogonial cell [Term] id: CL:0000655 name: secondary oocyte def: "A secondary oocyte is an oocyte that has not completed meiosis II." [] synonym: "primary oogonium" RELATED [] is_a: CL:0000023 ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007147 relationship: RO:0002202 CL:0000654 ! primary oocyte [Term] id: CL:0000656 name: primary spermatocyte def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [] is_a: CL:0000017 ! spermatocyte intersection_of: CL:0000017 ! spermatocyte intersection_of: RO:0000053 PATO:0001394 intersection_of: RO:0002215 GO:0007140 [Term] id: CL:0000657 name: secondary spermatocyte def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [] is_a: CL:0000017 ! spermatocyte is_a: CL:0000413 ! haploid cell intersection_of: CL:0000017 ! spermatocyte intersection_of: RO:0000053 PATO:0001375 intersection_of: RO:0002215 GO:0007142 relationship: RO:0002202 CL:0000656 ! primary spermatocyte [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000666 name: fenestrated cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000667 name: collagen secreting cell def: "An extracellular matrix secreting cell that secretes collagen." [] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000669 name: pericyte def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [] synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [] synonym: "cell of Rouget" EXACT [] synonym: "pericyte cell" EXACT [] synonym: "pericyte of Rouget" EXACT [] is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0008034 ! mural cell [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [] synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: BFO:0000050 UBERON:0000922 intersection_of: RO:0002215 GO:0048870 [Term] id: CL:0000671 name: centripetally migrating follicle cell def: "A follicle cell that migrates from the dorso-anterior part of the oocyte associated follicular epithelium, in between the nurse cells and the oocyte, and participates in the formation of the operculum." [] synonym: "centripetal follicle cell" EXACT [] is_a: CL:0000477 ! follicle cell of egg chamber [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [] is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000677 name: gut absorptive cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [] is_a: CL:0000000 ! cell relationship: BFO:0000050 UBERON:0001277 [Term] id: CL:0000678 name: commissural neuron is_a: CL:0000540 ! neuron [Term] id: CL:0000679 name: glutamatergic neuron def: "A neuron that is capable of some neurotansmission by glutamate secretion." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061535 [Term] id: CL:0000680 name: muscle precursor cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [] is_a: CL:0000055 ! non-terminally differentiated cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002203 CL:0000187 ! muscle cell relationship: RO:0002202 CL:0000222 ! mesodermal cell [Term] id: CL:0000681 name: radial glial cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [] synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000683 name: ependymoglial cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [] synonym: "ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0033326 relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0000691 name: stellate interneuron is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070010 [Term] id: CL:0000695 name: Cajal-Retzius cell def: "A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [] synonym: "CR cells" EXACT [] synonym: "Horizontal cells of Cajal" EXACT [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: RO:0000053 PATO:0070006 relationship: RO:0002100 UBERON:0010403 [Term] id: CL:0000696 name: PP cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [] synonym: "type F enteroendocrine cell" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000700 name: dopaminergic neuron def: "A neuron that releases dopamine as a neurotransmitter." [] synonym: "dopaminergic cell" EXACT [] is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061527 [Term] id: CL:0000704 name: endothelial tip cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000707 name: R7 photoreceptor cell synonym: "R7 cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: BFO:0000050 UBERON:0003210 [Term] id: CL:0000709 name: R8 photoreceptor cell synonym: "R8 cell" EXACT [] is_a: CL:0000488 ! visible light photoreceptor cell relationship: BFO:0000050 UBERON:0000971 [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [] synonym: "neuroepithelial cell" BROAD [] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [] is_a: CL:0000154 ! protein secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: RO:0002202 CL:0000501 ! granulosa cell [Term] id: CL:0000715 name: embryonic crystal cell def: "A crystal cell that derives from the embryonic head mesoderm." [] is_a: CL:0000392 ! crystal cell is_a: CL:0011008 ! embryonic hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell def: "A crystal cell that derives from the larval lymph gland." [] is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000718 name: compound eye cone cell def: "A cell of an ommatidium that secretes lens materials." [] synonym: "cone cell (sensu Endopterygota)" RELATED [] synonym: "Semper cell" EXACT [] is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000971 [Term] id: CL:0000722 name: cystoblast is_a: CL:0000586 ! germ cell relationship: RO:0002160 NCBITaxon:6656 [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [] is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 [Term] id: CL:0000724 name: heterocyst def: "A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [] is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0009399 [Term] id: CL:0000726 name: chlamydospore def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [] is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000730 name: leading edge cell def: "A cell at the front of a migrating epithelial sheet." [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000731 name: urothelial cell def: "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria." [] synonym: "urinary tract transitional epithelial cell" NARROW [] is_a: CL:0000244 ! transitional epithelial cell intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: BFO:0000050 UBERON:0000365 [Term] id: CL:0000733 name: lymph gland plasmatocyte def: "A plasmatocyte that derives from the larval lymph gland." [] is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte def: "A hemocyte that derives from the larval lymph gland." [] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 intersection_of: RO:0000053 PATO:0001410 disjoint_from: CL:0008000 ! non-striated muscle cell [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [] synonym: "immune cell" RELATED [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0002505 intersection_of: RO:0002215 GO:0001667 relationship: BFO:0000050 UBERON:0002405 relationship: RO:0002160 NCBITaxon:7742 relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" RELATED [] synonym: "RGCs" RELATED [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: RO:0002100 UBERON:0000966 [Term] id: CL:0000746 name: cardiac muscle cell def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [] synonym: "cardiac muscle fiber" EXACT [] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] is_a: CL:0000187 ! muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0007100 intersection_of: BFO:0000051 GO:0030017 intersection_of: RO:0000053 PATO:0002478 intersection_of: RO:0000056 GO:0060047 relationship: RO:0002202 CL:0000513 ! cardiac muscle myoblast [Term] id: CL:0000747 name: cyanophore def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: RO:0002202 CL:0005005 ! cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [] synonym: "BC" RELATED [] synonym: "BCs" RELATED [] synonym: "BPs" RELATED [] is_a: CL:0000103 ! bipolar neuron is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0008028 ! visual system neuron is_a: CL:0009004 ! retinal cell intersection_of: CL:0000103 ! bipolar neuron intersection_of: RO:0002100 UBERON:0001791 relationship: RO:0002216 GO:0007601 [Term] id: CL:0000749 name: ON-bipolar cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." [] is_a: CL:0000749 ! ON-bipolar cell relationship: RO:0002102 UBERON:0008925 relationship: RO:0002102 UBERON:0008926 relationship: RO:0002103 CL:0000604 ! retinal rod cell relationship: RO:0002160 NCBITaxon:40674 [Term] id: CL:0000752 name: cone retinal bipolar cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [] is_a: CL:0000748 ! retinal bipolar neuron intersection_of: CL:0000748 ! retinal bipolar neuron intersection_of: RO:0002103 CL:0000573 ! retinal cone cell [Term] id: CL:0000762 name: nucleated thrombocyte def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [] is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: RO:0000053 PATO:0001407 intersection_of: RO:0002215 GO:0007596 relationship: RO:0002202 CL:0000828 ! thromboblast [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [] is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell def: "A immature or mature cell in the lineage leading to and including erythrocytes." [] synonym: "erythropoietic cell" EXACT [] is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [] synonym: "normoblast" EXACT [] is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 GO:0005634 intersection_of: lacks_part GO:0005730 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: RO:0002215 GO:0030218 relationship: RO:0002202 CL:0000547 ! proerythroblast [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [] is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [] synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000094 ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001344 intersection_of: RO:0002104 PR:000001950 intersection_of: RO:0015015 PR:000001255 intersection_of: RO:0015015 PR:000001865 intersection_of: RO:0015015 PR:000007431 [Term] id: CL:0000768 name: immature basophil def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 ! basophil intersection_of: CL:0000767 ! basophil intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus relationship: RO:0002202 CL:0000830 ! basophilic promyelocyte [Term] id: CL:0000769 name: basophilic metamyelocyte def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [] is_a: CL:0000768 ! immature basophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 CL:0017507 ! reniform nucleus intersection_of: BFO:0000051 GO:0000792 intersection_of: BFO:0000051 GO:0042582 intersection_of: BFO:0000051 GO:0070820 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001456 intersection_of: RO:0002104 PR:000001483 intersection_of: RO:0002104 PR:000001892 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002031 relationship: RO:0002202 CL:0000614 ! basophilic myelocyte [Term] id: CL:0000770 name: band form basophil def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [] is_a: CL:0000768 ! immature basophil intersection_of: CL:0000768 ! immature basophil intersection_of: BFO:0000051 CL:0017506 ! banded nucleus relationship: RO:0002202 CL:0000769 ! basophilic metamyelocyte [Term] id: CL:0000771 name: eosinophil def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [] synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000094 ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001254 intersection_of: RO:0002104 PR:000001255 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002104 PR:000005178 [Term] id: CL:0000772 name: immature eosinophil def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 ! eosinophil intersection_of: CL:0000771 ! eosinophil intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus relationship: RO:0002202 CL:0000833 ! eosinophilic promyelocyte [Term] id: CL:0000773 name: eosinophilic metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [] is_a: CL:0000772 ! immature eosinophil is_a: CL:0002192 ! metamyelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 CL:0017502 ! acidophilic cytoplasm intersection_of: BFO:0000051 CL:0017507 ! reniform nucleus intersection_of: BFO:0000051 GO:0000792 intersection_of: BFO:0000051 GO:0042582 intersection_of: BFO:0000051 GO:0070820 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001456 intersection_of: RO:0002104 PR:000001483 intersection_of: RO:0002104 PR:000001892 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002031 relationship: RO:0002202 CL:0000612 ! eosinophilic myelocyte [Term] id: CL:0000774 name: band form eosinophil def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil." [] is_a: CL:0000772 ! immature eosinophil intersection_of: CL:0000772 ! immature eosinophil intersection_of: BFO:0000051 CL:0017506 ! banded nucleus relationship: RO:0002202 CL:0000773 ! eosinophilic metamyelocyte [Term] id: CL:0000775 name: neutrophil def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] is_a: CL:0000094 ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001479 intersection_of: RO:0002104 PR:000001879 [Term] id: CL:0000776 name: immature neutrophil def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 ! neutrophil intersection_of: CL:0000775 ! neutrophil intersection_of: BFO:0000051 CL:0017509 ! alobate nucleus relationship: RO:0002202 CL:0000564 ! neutrophilic promyelocyte [Term] id: CL:0000777 name: mesangial phagocyte def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0001025 UBERON:0002320 intersection_of: RO:0002215 GO:0019882 intersection_of: RO:0002215 GO:0048771 [Term] id: CL:0000778 name: mononuclear osteoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [] is_a: CL:0000092 ! osteoclast is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001407 [Term] id: CL:0000779 name: multinuclear osteoclast def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [] synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 ! osteoclast is_a: CL:0000783 ! multinucleated phagocyte intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001908 relationship: RO:0002202 CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [] synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: RO:0000053 PATO:0001908 relationship: RO:0002202 CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [] is_a: CL:0000588 ! odontoclast is_a: CL:0000778 ! mononuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: RO:0000053 PATO:0001407 [Term] id: CL:0000782 name: myeloid dendritic cell def: "A dendritic cell of the myeloid lineage." [] synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001865 intersection_of: RO:0002202 CL:0000763 ! myeloid cell [Term] id: CL:0000783 name: multinucleated phagocyte def: "A phagocyte formed by the fusion of mononuclear phagocytes." [] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001908 [Term] id: CL:0000784 name: plasmacytoid dendritic cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0002215 GO:0032606 relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000785 name: mature B cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [] synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0001201 ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: RO:0002215 GO:0002504 intersection_of: RO:0002215 GO:0042113 intersection_of: RO:0002353 GO:0002335 disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: RO:0002202 CL:0000818 ! transitional stage B cell [Term] id: CL:0000786 name: plasma cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [] synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000946 ! antibody secreting cell intersection_of: BFO:0000051 CL:0017508 ! cartwheel heterochromatin intersection_of: BFO:0000051 GO:0005794 intersection_of: lacks_plasma_membrane_part GO:0019814 intersection_of: lacks_plasma_membrane_part GO:0042613 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: RO:0002104 PR:000001935 relationship: RO:0002202 CL:0000980 ! plasmablast [Term] id: CL:0000787 name: memory B cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [] synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001935 intersection_of: RO:0002104 GO:0042613 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002353 GO:0002344 [Term] id: CL:0000788 name: naive B cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [] synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_not_completed GO:0002344 intersection_of: lacks_plasma_membrane_part PR:000001963 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001289 relationship: RO:0002202 CL:0000818 ! transitional stage B cell [Term] id: CL:0000789 name: alpha-beta T cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042105 disjoint_from: CL:0000798 ! gamma-delta T cell [Term] id: CL:0000790 name: immature alpha-beta T cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_not_completed GO:0045058 [Term] id: CL:0000791 name: mature alpha-beta T cell def: "A alpha-beta T cell that has a mature phenotype." [] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 ! alpha-beta T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: RO:0002353 GO:0045058 relationship: RO:0002202 CL:0000790 ! immature alpha-beta T cell [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002104 PR:000001380 intersection_of: RO:0002215 GO:0050777 intersection_of: RO:0015016 PR:000001869 [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0001025 UBERON:0001277 intersection_of: RO:0002215 GO:0002385 relationship: RO:0002202 CL:0000810 ! CD4-positive, alpha-beta thymocyte [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: BFO:0000051 PR:000003466 intersection_of: BFO:0000051 PR:000003499 intersection_of: RO:0002215 GO:0001913 intersection_of: RO:0002215 GO:0033380 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0050777 [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: RO:0002104 PR:000025402 [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0001025 UBERON:0001277 intersection_of: RO:0002215 GO:0002385 [Term] id: CL:0000798 name: gamma-delta T cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [] synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042106 [Term] id: CL:0000799 name: immature gamma-delta T cell def: "A gamma-delta T cell that has an immature phenotype." [] synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_not_completed GO:0042492 intersection_of: has_not_completed GO:0045058 relationship: RO:0002202 CL:0000807 ! DN3 thymocyte [Term] id: CL:0000800 name: mature gamma-delta T cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: RO:0002353 GO:0045058 relationship: RO:0002202 CL:0000799 ! immature gamma-delta T cell [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0001025 UBERON:0001277 intersection_of: RO:0002215 GO:0002385 [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: RO:0002104 PR:000001084 [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 [Term] id: CL:0000805 name: immature single positive thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [] synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001307 intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: RO:0002104 GO:0043384 intersection_of: RO:0002104 PR:000025402 intersection_of: RO:0015015 PR:000001932 relationship: RO:0002202 CL:0000808 ! DN4 thymocyte [Term] id: CL:0000806 name: DN2 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [] synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0002104 PR:000001380 relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000807 name: DN3 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001307 intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 GO:0043384 intersection_of: RO:0002104 PR:000001380 relationship: RO:0002202 CL:0000806 ! DN2 thymocyte [Term] id: CL:0000808 name: DN4 thymocyte def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [] synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "early cortical thymocyte" BROAD [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001307 intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 GO:0043384 relationship: RO:0002202 CL:0000807 ! DN3 thymocyte [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [] synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] synonym: "late cortical thymocyte" BROAD [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002104 PR:000025402 relationship: RO:0002202 CL:0000805 ! immature single positive thymocyte [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002104 PR:000001004 relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: RO:0002104 PR:000025402 relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000813 name: memory T cell def: "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." [] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0000053 PATO:0001603 intersection_of: RO:0002353 GO:0002286 intersection_of: RO:0002353 GO:0043379 disjoint_from: CL:0000898 ! naive T cell [Term] id: CL:0000814 name: mature NK T cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0002104 PR:000001874 intersection_of: RO:0002215 GO:0032394 intersection_of: RO:0002215 GO:0045087 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0002042 ! immature NK T cell stage IV [Term] id: CL:0000815 name: regulatory T cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [] synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" EXACT [] is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002215 GO:0050777 [Term] id: CL:0000816 name: immature B cell def: "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [] synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [] is_a: CL:0001201 ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: has_not_completed GO:0045190 intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001289 relationship: RO:0002202 CL:0000954 ! small pre-B-II cell [Term] id: CL:0000817 name: precursor B cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [] synonym: "pre-B cell" RELATED [] is_a: CL:0001201 ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: lacks_plasma_membrane_part GO:0071753 intersection_of: RO:0002104 PR:000001898 disjoint_from: CL:0000826 ! pro-B cell [Term] id: CL:0000818 name: transitional stage B cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [] synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional B cell" EXACT [] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0001201 ! B cell, CD19-positive intersection_of: CL:0001201 ! B cell, CD19-positive intersection_of: has_not_completed GO:0002335 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0015015 PR:000001408 intersection_of: RO:0015015 PR:000001932 relationship: RO:0002202 CL:0000816 ! immature B cell [Term] id: CL:0000819 name: B-1 B cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [] synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002215 GO:0045087 intersection_of: RO:0015015 GO:0071753 [Term] id: CL:0000820 name: B-1a B cell def: "A B-1 B cell that has the phenotype CD5-positive." [] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: RO:0002104 PR:000001839 [Term] id: CL:0000821 name: B-1b B cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: lacks_plasma_membrane_part PR:000001839 [Term] id: CL:0000822 name: B-2 B cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [] synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001879 intersection_of: RO:0002104 PR:000001289 [Term] id: CL:0000823 name: immature natural killer cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [] synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [] is_a: CL:0000623 ! natural killer cell is_a: CL:0001082 ! immature innate lymphoid cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0000053 PATO:0001501 disjoint_from: CL:0000937 ! pre-natural killer cell relationship: RO:0002202 CL:0000937 ! pre-natural killer cell [Term] id: CL:0000825 name: pro-NK cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [] synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [] synonym: "null cell" RELATED [] synonym: "preNK cell" RELATED [] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001381 intersection_of: RO:0002104 PR:000001898 relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000826 name: pro-B cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [] synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [] synonym: "pre-pro B cell" BROAD [] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000001903 intersection_of: BFO:0000051 PR:000006611 intersection_of: RO:0000056 GO:0033152 relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000827 name: pro-T cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor [Term] id: CL:0000828 name: thromboblast def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [] is_a: CL:0000226 ! single nucleate cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0000053 PATO:0001407 intersection_of: RO:0002215 GO:0002574 relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000829 name: basophilic myeloblast def: "A myeloblast committed to the basophil lineage." [] is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030221 relationship: RO:0002202 CL:0000613 ! basophil progenitor cell [Term] id: CL:0000830 name: basophilic promyelocyte def: "A promyelocyte committed to the basophil lineage." [] is_a: CL:0000836 ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030221 relationship: RO:0002202 CL:0000829 ! basophilic myeloblast [Term] id: CL:0000831 name: mast cell progenitor def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [] synonym: "CFU-Mast" RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000007858 intersection_of: lacks_part PR:000005307 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000001963 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: lacks_plasma_membrane_part PR:000002980 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000005178 intersection_of: RO:0002104 PR:000016401 intersection_of: RO:0002215 GO:0060374 intersection_of: RO:0015015 PR:000009143 intersection_of: RO:0015016 PR:000002065 intersection_of: RO:0015016 PR:000007431 relationship: RO:0002202 CL:0002028 ! basophil mast progenitor cell [Term] id: CL:0000832 name: eosinophilic myeloblast def: "A myeloblast committed to the eosinophil lineage." [] is_a: CL:0000835 ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030222 relationship: RO:0002202 CL:0000611 ! eosinophil progenitor cell [Term] id: CL:0000833 name: eosinophilic promyelocyte def: "A promyelocyte committed to the eosinophil lineage." [] is_a: CL:0000836 ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030222 relationship: RO:0002202 CL:0000832 ! eosinophilic myeloblast [Term] id: CL:0000834 name: neutrophil progenitor cell def: "A progenitor cell of the neutrophil lineage." [] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: RO:0002215 GO:0030223 relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000835 name: myeloblast def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 intersection_of: lacks_part GO:0042582 intersection_of: RO:0000053 PATO:0040072 relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000836 name: promyelocyte def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 CL:0017503 ! basophilic cytoplasm intersection_of: BFO:0000051 GO:0005730 intersection_of: BFO:0000051 GO:0042582 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001483 intersection_of: lacks_plasma_membrane_part PR:000001932 intersection_of: RO:0000053 PATO:0040072 intersection_of: RO:0002104 PR:000001456 intersection_of: RO:0002104 PR:000001892 relationship: RO:0002202 CL:0000835 ! myeloblast [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [] synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0000053 PATO:0001402 intersection_of: RO:0002104 PR:000001003 disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell def: "A progenitor cell restricted to the lymphoid lineage." [] synonym: "lymphoid progenitor cell" BROAD [] is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030098 disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [] synonym: "myeloid progenitor cell" BROAD [] is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 [Term] id: CL:0000840 name: immature conventional dendritic cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0015016 GO:0042613 intersection_of: RO:0015016 PR:000001412 intersection_of: RO:0015016 PR:000001438 relationship: RO:0002202 CL:0001029 ! common dendritic progenitor [Term] id: CL:0000841 name: mature conventional dendritic cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [] synonym: "mature dendritic cell" BROAD [] synonym: "mature myeloid dendritic cell" NARROW [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001310 intersection_of: RO:0015015 GO:0042613 intersection_of: RO:0015015 PR:000001412 intersection_of: RO:0015015 PR:000001438 relationship: RO:0002202 CL:0000840 ! immature conventional dendritic cell [Term] id: CL:0000842 name: mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [] synonym: "mononuclear leukocyte" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0000053 PATO:0001407 [Term] id: CL:0000843 name: follicular B cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [] synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001879 intersection_of: lacks_plasma_membrane_part PR:000002037 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002104 PR:000001338 [Term] id: CL:0000844 name: germinal center B cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [] synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0001745 intersection_of: RO:0002104 PR:000001289 relationship: RO:0002202 CL:0000843 ! follicular B cell [Term] id: CL:0000845 name: marginal zone B cell of spleen def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [] synonym: "B cell of marginal zone of spleen" EXACT [] synonym: "marginal zone B cell" BROAD [] synonym: "marginal zone B lymphocyte" BROAD [] synonym: "marginal zone B-cell" BROAD [] synonym: "marginal zone B-lymphocyte" BROAD [] synonym: "marginal zone of spleen B cell" EXACT [] synonym: "MZ B cell" BROAD [] synonym: "MZ B lymphocyte" BROAD [] synonym: "MZ B-cell" BROAD [] synonym: "MZ B-lymphocyte" BROAD [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0001251 intersection_of: lacks_plasma_membrane_part PR:000001880 intersection_of: lacks_plasma_membrane_part PR:000002037 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002104 PR:000001338 intersection_of: RO:0002215 GO:0042742 intersection_of: RO:0015015 GO:0071753 [Term] id: CL:0000847 name: ciliated olfactory receptor neuron def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell intersection_of: CL:0000207 ! olfactory receptor cell intersection_of: BFO:0000051 GO:0005929 [Term] id: CL:0000850 name: serotonergic neuron def: "A neuron that releases serotonin as a neurotransmitter." [] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0060096 [Term] id: CL:0000851 name: neuromast mantle cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [] is_a: CL:0000151 ! secretory cell disjoint_from: CL:0000855 ! sensory hair cell relationship: BFO:0000050 UBERON:0008904 [Term] id: CL:0000852 name: neuromast supporting cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [] synonym: "neuromast support cell" EXACT [] is_a: CL:0000630 ! supporting cell disjoint_from: CL:0000855 ! sensory hair cell relationship: BFO:0000050 UBERON:0008904 [Term] id: CL:0000855 name: sensory hair cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [] synonym: "hair cell" BROAD [] is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [] is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: BFO:0000050 UBERON:0008904 [Term] id: CL:0000857 name: slow muscle myoblast def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [] is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000189 ! slow muscle cell [Term] id: CL:0000860 name: classical monocyte def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [] synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: RO:0002215 GO:0002548 intersection_of: RO:0002215 GO:0006909 intersection_of: RO:0002215 GO:0006954 intersection_of: RO:0015015 PR:000001199 [Term] id: CL:0000861 name: elicited macrophage def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [] synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0006954 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001813 intersection_of: RO:0002104 PR:000002064 relationship: RO:0002202 CL:0000860 ! classical monocyte [Term] id: CL:0000862 name: suppressor macrophage def: "A macrophage that suppresses immune responses." [] is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 [Term] id: CL:0000863 name: inflammatory macrophage def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [] synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0032611 intersection_of: RO:0002215 GO:0032635 intersection_of: RO:0002215 GO:0032640 intersection_of: RO:0002215 GO:0042554 intersection_of: RO:0002215 GO:0042742 intersection_of: RO:0002215 GO:0051767 [Term] id: CL:0000864 name: tissue-resident macrophage def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0000479 [Term] id: CL:0000866 name: thymic macrophage def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0002370 intersection_of: RO:0002215 GO:0043277 [Term] id: CL:0000875 name: non-classical monocyte def: "A type of monocyte characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, and decrease size relative to classical monocytes, but increased co-stimulatory activity. May also play a role in tissue repair." [] synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: RO:0000053 PATO:0000587 intersection_of: RO:0002215 GO:0031294 intersection_of: RO:0002353 GO:0030224 intersection_of: RO:0015015 PR:000001206 relationship: RO:0002202 CL:0002393 ! intermediate monocyte [Term] id: CL:0000878 name: central nervous system macrophage def: "A tissue-resident macrophage found in the central nervous system." [] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0001017 [Term] id: CL:0000889 name: myeloid suppressor cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [] is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001501 intersection_of: RO:0002104 PR:000001006 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002215 GO:0050777 [Term] id: CL:0000891 name: foam cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] is_a: CL:0000000 ! cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [] is_a: CL:0000891 ! foam cell relationship: RO:0002202 CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte def: "An immature T cell located in the thymus." [] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] is_a: CL:0002420 ! immature T cell intersection_of: CL:0000084 ! T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: has_not_completed GO:0045058 [Term] id: CL:0000894 name: DN1 thymic pro-T cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: RO:0002104 PR:000001307 relationship: RO:0002202 CL:0002425 ! early T lineage precursor [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [] synonym: "naive CD4+ T cell" BROAD [] synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001203 intersection_of: RO:0002104 PR:000001869 intersection_of: RO:0015015 PR:000001318 intersection_of: RO:0015016 PR:000001307 relationship: RO:0002202 CL:0002436 ! mature CD4 single-positive thymocyte [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001318 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002104 PR:000001380 relationship: RO:0002202 CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell def: "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." [] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0000053 PATO:0001603 intersection_of: RO:0002353 GO:0002286 intersection_of: RO:0002353 GO:0043379 [Term] id: CL:0000898 name: naive T cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001203 intersection_of: RO:0002104 PR:000001869 intersection_of: RO:0002353 GO:0045058 intersection_of: RO:0015015 PR:000001318 intersection_of: RO:0015016 PR:000001307 [Term] id: CL:0000899 name: T-helper 17 cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [] synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 CD4+ T cell" EXACT [] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000003455 intersection_of: lacks_plasma_membrane_part PR:000001207 intersection_of: RO:0002104 PR:000001202 intersection_of: RO:0002215 GO:0032620 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [] synonym: "naive CD8+ T cell" BROAD [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001203 intersection_of: RO:0002104 PR:000001869 intersection_of: RO:0015015 PR:000001318 intersection_of: RO:0015016 PR:000001307 relationship: RO:0002202 CL:0002437 ! mature CD8 single-positive thymocyte [Term] id: CL:0000901 name: Tr1 cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [] synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0032613 intersection_of: RO:0002215 GO:0050777 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001203 intersection_of: lacks_plasma_membrane_part PR:000001318 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002104 PR:000001380 relationship: RO:0002202 CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001318 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002104 PR:000001380 intersection_of: RO:0002215 GO:0001816 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0000906 ! activated CD8-positive, alpha-beta T cell [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell def: "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." [] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" RELATED [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0000053 PATO:0001603 intersection_of: RO:0002353 GO:0002286 intersection_of: RO:0002353 GO:0043379 [Term] id: CL:0000910 name: cytotoxic T cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001913 [Term] id: CL:0000911 name: effector T cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0000053 PATO:0045026 intersection_of: RO:0002353 GO:0030217 intersection_of: RO:0002353 GO:0045058 [Term] id: CL:0000912 name: helper T cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001816 [Term] id: CL:0000914 name: immature NK T cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 ! immature alpha-beta T cell intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: BFO:0000051 PR:000003469 relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: RO:0002104 PR:000001084 relationship: RO:0002202 CL:0000811 ! CD8-positive, alpha-beta thymocyte [Term] id: CL:0000916 name: dendritic epidermal T cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [] synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0001025 UBERON:0001003 intersection_of: RO:0002215 GO:0060054 relationship: RO:0002202 CL:0002401 ! mature dendritic epithelial T cell precursor [Term] id: CL:0000918 name: Tc2 cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [] synonym: "CD8-positive Th2 cell" EXACT [] synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] synonym: "Th2 CD8-positive T cell" EXACT [] synonym: "Th2 non-TFH CD8-positive T cell" EXACT [] is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell is_a: CL:0001052 ! CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: BFO:0000051 PR:000001941 intersection_of: lacks_plasma_membrane_part PR:000001202 intersection_of: lacks_plasma_membrane_part PR:000001207 intersection_of: RO:0002215 GO:0032633 [Term] id: CL:0000921 name: type I NK T cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [] synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0043208 [Term] id: CL:0000922 name: type II NK T cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0002288 [Term] id: CL:0000923 name: CD4-positive type I NK T cell def: "A type I NK T cell that has the phenotype CD4-positive." [] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000921 ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002215 GO:0032609 intersection_of: RO:0002215 GO:0032633 relationship: RO:0002202 CL:0000923 ! CD4-positive type I NK T cell [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002215 GO:0002827 intersection_of: RO:0002215 GO:0032609 relationship: RO:0002202 CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002215 GO:0002830 intersection_of: RO:0002215 GO:0032616 intersection_of: RO:0002215 GO:0032633 relationship: RO:0002202 CL:0000925 ! activated CD4-positive type I NK T cell [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002215 GO:0002369 relationship: RO:0002202 CL:0000924 ! CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002215 GO:0002827 intersection_of: RO:0002215 GO:0032609 relationship: RO:0002202 CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002215 GO:0002830 intersection_of: RO:0002215 GO:0032633 relationship: RO:0002202 CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell [Term] id: CL:0000931 name: activated type II NK T cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000922 ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002215 GO:0002369 [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000922 ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002215 GO:0032609 relationship: RO:0002202 CL:0000931 ! activated type II NK T cell [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000922 ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0002215 GO:0032633 relationship: RO:0002202 CL:0000931 ! activated type II NK T cell [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001913 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0000936 name: early lymphoid progenitor def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [] synonym: "ELP" RELATED [] synonym: "GMLP" RELATED [] synonym: "LMPP" RELATED [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001460 intersection_of: RO:0002104 PR:000002001 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000002979 intersection_of: RO:0002215 GO:0030098 relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell [Term] id: CL:0000937 name: pre-natural killer cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [] synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001381 intersection_of: RO:0002104 PR:000002065 [Term] id: CL:0000940 name: mucosal invariant T cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: RO:0002215 GO:0002227 intersection_of: RO:0002215 GO:0032394 intersection_of: RO:0002353 GO:0030217 [Term] id: CL:0000941 name: thymic conventional dendritic cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: RO:0002104 PR:000001013 relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [] is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001865 relationship: RO:0002202 CL:0000894 ! DN1 thymic pro-T cell [Term] id: CL:0000943 name: Be1 Cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [] synonym: "B effector 1 cell" EXACT [] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032609 intersection_of: RO:0002215 GO:0032623 intersection_of: RO:0002215 GO:0032640 intersection_of: RO:0002215 GO:0045627 [Term] id: CL:0000944 name: Be2 cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [] synonym: "B effector 2 cell" EXACT [] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032613 intersection_of: RO:0002215 GO:0032623 intersection_of: RO:0002215 GO:0032633 intersection_of: RO:0002215 GO:0032635 intersection_of: RO:0002215 GO:0045630 [Term] id: CL:0000945 name: lymphocyte of B lineage def: "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex." [] is_a: CL:0000542 ! lymphocyte relationship: RO:0002202 CL:0000826 ! pro-B cell [Term] id: CL:0000946 name: antibody secreting cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [] is_a: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0003000 GO:0042571 [Term] id: CL:0000947 name: IgE plasma cell def: "A long lived plasma cell that secretes IgE." [] is_a: CL:0000974 ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071743 [Term] id: CL:0000948 name: IgE memory B cell def: "A class switched memory B cell that expresses IgE on the cell surface." [] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071742 [Term] id: CL:0000949 name: IgD plasmablast def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071739 [Term] id: CL:0000950 name: IgE plasmablast def: "A plasmablast that secretes IgE." [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071743 [Term] id: CL:0000951 name: IgE short lived plasma cell def: "A short lived plasma cell that secretes IgE." [] is_a: CL:0000975 ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071743 [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [] is_a: CL:0000957 ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 intersection_of: RO:0002104 GO:0035369 intersection_of: RO:0002104 PR:000001858 intersection_of: RO:0002104 PR:000001859 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [] is_a: CL:0000957 ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 intersection_of: lacks_plasma_membrane_part GO:0035369 intersection_of: lacks_plasma_membrane_part PR:000001858 intersection_of: lacks_plasma_membrane_part PR:000001859 [Term] id: CL:0000954 name: small pre-B-II cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [] synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: BFO:0000051 PR:000003457 intersection_of: BFO:0000051 PR:000003460 intersection_of: lacks_plasma_membrane_part GO:0019815 intersection_of: lacks_plasma_membrane_part GO:0035369 intersection_of: RO:0000056 GO:0071708 [Term] id: CL:0000955 name: pre-B-II cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [] synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: lacks_part PR:000006611 intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: RO:0002353 GO:0071707 disjoint_from: CL:0000956 ! pre-B-I cell relationship: RO:0002202 CL:0000826 ! pro-B cell [Term] id: CL:0000956 name: pre-B-I cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [] synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: BFO:0000051 PR:000003457 intersection_of: BFO:0000051 PR:000003460 intersection_of: BFO:0000051 PR:000006611 intersection_of: RO:0000056 GO:0071707 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001858 intersection_of: RO:0002104 PR:000001859 relationship: RO:0002202 CL:0000826 ! pro-B cell [Term] id: CL:0000957 name: large pre-B-II cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [] synonym: "large pre-B cell" BROAD [] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: lacks_part PR:000003457 intersection_of: lacks_part PR:000003460 intersection_of: RO:0000056 GO:0046651 [Term] id: CL:0000958 name: T1 B cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [] synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: lacks_plasma_membrane_part PR:000001318 intersection_of: lacks_plasma_membrane_part PR:000001338 intersection_of: lacks_plasma_membrane_part PR:000001880 intersection_of: RO:0002104 PR:000002037 [Term] id: CL:0000959 name: T2 B cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [] synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: lacks_plasma_membrane_part PR:000001318 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001338 intersection_of: RO:0002104 PR:000001880 intersection_of: RO:0002104 PR:000002037 relationship: RO:0002202 CL:0000958 ! T1 B cell [Term] id: CL:0000960 name: T3 B cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [] synonym: "An1 B cell" EXACT [] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: RO:0000056 GO:0002515 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001318 intersection_of: RO:0002104 PR:000001338 intersection_of: RO:0002104 PR:000001880 relationship: RO:0002202 CL:0000959 ! T2 B cell [Term] id: CL:0000961 name: Bm1 B cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [] synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell is_a: CL:0002056 ! fraction F mature B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: lacks_plasma_membrane_part PR:000001408 intersection_of: lacks_plasma_membrane_part PR:000001880 intersection_of: RO:0002104 GO:0071738 relationship: RO:0002202 CL:0000818 ! transitional stage B cell [Term] id: CL:0000962 name: Bm2 B cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [] synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000001880 relationship: RO:0002202 CL:0000961 ! Bm1 B cell [Term] id: CL:0000963 name: Bm3-delta B cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: lacks_plasma_membrane_part GO:0071753 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 PR:000001408 relationship: RO:0002202 CL:0000965 ! Bm3 B cell [Term] id: CL:0000964 name: Bm2' B cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [] synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B-lymphocyte" EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: lacks_plasma_membrane_part PR:000001880 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002215 GO:0002634 relationship: RO:0002202 CL:0000962 ! Bm2 B cell [Term] id: CL:0000965 name: Bm3 B cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [] synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [] is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000003516 intersection_of: RO:0002215 GO:0016446 relationship: RO:0002202 CL:0000964 ! Bm2' B cell [Term] id: CL:0000966 name: Bm4 B cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [] synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [] is_a: CL:0000844 ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: lacks_plasma_membrane_part PR:000003516 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002353 GO:0016446 relationship: RO:0002202 CL:0000963 ! Bm3-delta B cell [Term] id: CL:0000967 name: Bm5 B cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [] synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: RO:0002353 GO:0002314 intersection_of: RO:0002353 GO:0016446 relationship: RO:0002202 CL:0000966 ! Bm4 B cell [Term] id: CL:0000968 name: Be cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002215 GO:0001816 intersection_of: RO:0002215 GO:0043370 [Term] id: CL:0000970 name: unswitched memory B cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [] synonym: "IgD+ memory B cell" BROAD [] synonym: "non-class-switched memory B cell" EXACT [] synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 intersection_of: lacks_plasma_membrane_part GO:0071742 intersection_of: lacks_plasma_membrane_part GO:0071745 intersection_of: lacks_plasma_membrane_part PR:000001935 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001963 relationship: RO:0002202 CL:0000980 ! plasmablast [Term] id: CL:0000971 name: IgM memory B cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [] synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: RO:0002104 GO:0071753 [Term] id: CL:0000972 name: class switched memory B cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface." [] synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071753 intersection_of: RO:0002104 PR:000001963 intersection_of: RO:0002353 GO:0045190 relationship: RO:0002202 CL:0000970 ! unswitched memory B cell [Term] id: CL:0000973 name: IgA memory B cell def: "A class switched memory B cell that expresses IgA." [] synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071745 [Term] id: CL:0000974 name: long lived plasma cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [] is_a: CL:0000786 ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: lacks_plasma_membrane_part GO:0019814 intersection_of: lacks_plasma_membrane_part GO:0042613 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001408 intersection_of: RO:0015015 PR:000001208 intersection_of: RO:0015015 PR:000001935 intersection_of: RO:0015016 PR:000001002 relationship: RO:0002202 CL:0000975 ! short lived plasma cell [Term] id: CL:0000975 name: short lived plasma cell def: "A fully differentiated plasma cell that lives for months." [] is_a: CL:0000786 ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: RO:0000053 PATO:0001604 relationship: RO:0002202 CL:0000980 ! plasmablast [Term] id: CL:0000976 name: IgA short lived plasma cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [] is_a: CL:0000975 ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071746 [Term] id: CL:0000977 name: IgG short lived plasma cell def: "A short lived plasma cell that secretes IgG." [] is_a: CL:0000975 ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071736 [Term] id: CL:0000978 name: IgM short lived plasma cell def: "A short lived plasma cell that secretes IgM." [] is_a: CL:0000975 ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: RO:0003000 GO:0071754 [Term] id: CL:0000979 name: IgG memory B cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: RO:0002104 GO:0071735 [Term] id: CL:0000980 name: plasmablast def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [] synonym: "CD20-negative B cell" BROAD [] synonym: "CD27-positive, CD38-positive, CD20-negative B cell" EXACT [] is_a: CL:0000785 ! mature B cell is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001935 intersection_of: RO:0003000 GO:0042571 intersection_of: RO:0015015 PR:000001408 intersection_of: RO:0015015 PR:000001963 relationship: RO:0002202 CL:0000785 ! mature B cell [Term] id: CL:0000981 name: double negative memory B cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: lacks_plasma_membrane_part PR:000001963 [Term] id: CL:0000982 name: IgG plasmablast def: "A plasmablast that secretes IgG." [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071736 [Term] id: CL:0000983 name: IgM plasmablast def: "A plasmablast that secretes IgM." [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071754 [Term] id: CL:0000984 name: IgA plasmablast def: "A plasmablast that secretes IgA." [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0003000 GO:0071746 [Term] id: CL:0000985 name: IgG plasma cell def: "A fully differentiated plasma cell that secretes IgG." [] is_a: CL:0000974 ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071736 [Term] id: CL:0000986 name: IgM plasma cell def: "A fully differentiated plasma cell that secretes IgM." [] is_a: CL:0000974 ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071754 [Term] id: CL:0000987 name: IgA plasma cell def: "A fully differentiated plasma cell that secretes IgA." [] is_a: CL:0000974 ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: RO:0003000 GO:0071746 [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [] synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] is_a: CL:0000000 ! cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [] is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000002978 intersection_of: RO:0015016 PR:000001013 [Term] id: CL:0000990 name: conventional dendritic cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [] synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0015015 PR:000001013 [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0015016 PR:000001412 intersection_of: RO:0015016 PR:000001438 relationship: RO:0002202 CL:0001029 ! common dendritic progenitor [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0002104 PR:000001310 intersection_of: RO:0015015 GO:0042613 intersection_of: RO:0015015 PR:000001412 intersection_of: RO:0015015 PR:000001438 relationship: RO:0002202 CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [] synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: lacks_plasma_membrane_part PR:000001014 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001308 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000001896 intersection_of: lacks_plasma_membrane_part PR:000002977 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000001833 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000002979 disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [] synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000001898 disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001022 name: CD115-positive monocyte def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [] is_a: CL:0000576 ! monocyte is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000002062 relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [] synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0015016 GO:0033001 intersection_of: RO:0015016 PR:000001481 disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [] synonym: "CD133-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001408 intersection_of: lacks_plasma_membrane_part PR:000001483 intersection_of: lacks_plasma_membrane_part PR:000001892 intersection_of: lacks_plasma_membrane_part PR:000001945 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001786 intersection_of: RO:0002104 PR:000001809 intersection_of: RO:0002104 PR:000001843 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [] synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: lacks_plasma_membrane_part PR:000001014 intersection_of: RO:0002104 PR:000001869 intersection_of: RO:0002104 PR:000001963 intersection_of: RO:0002104 PR:000002001 intersection_of: RO:0002104 PR:000002037 intersection_of: RO:0015016 PR:000002065 intersection_of: RO:0015016 PR:000002979 relationship: RO:0002202 CL:0000936 ! early lymphoid progenitor [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [] synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: lacks_plasma_membrane_part PR:000001836 intersection_of: lacks_plasma_membrane_part PR:000001867 intersection_of: lacks_plasma_membrane_part PR:000001898 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0015016 PR:000001865 relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [] synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: lacks_plasma_membrane_part PR:000001836 intersection_of: RO:0002104 PR:000001003 relationship: RO:0002202 CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [] synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001836 relationship: RO:0002202 CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [] synonym: "CDP" EXACT [] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [] is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000002001 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0015016 PR:000002065 relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [] synonym: "granule cell of the cerebellum" EXACT [] is_a: CL:0000120 ! granule cell is_a: CL:2000028 ! cerebellum glutamatergic neuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0002037 relationship: RO:0002207 CL:0002362 ! cerebellar granule cell precursor [Term] id: CL:0001032 name: cortical granule cell def: "Granule cell that is part of the cerebral cortex." [] is_a: CL:0000120 ! granule cell is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0000956 [Term] id: CL:0001033 name: hippocampal granule cell def: "Granule cell with a soma found in the hippocampus." [] is_a: CL:0000120 ! granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0002421 [Term] id: CL:0001035 name: bone cell def: "A connective tissue cell found in bone." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001474 [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [] synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: BFO:0000051 PR:000001207 intersection_of: RO:0002215 GO:0032613 intersection_of: RO:0002215 GO:0032689 intersection_of: RO:0002215 GO:0042130 [Term] id: CL:0001042 name: T-helper 22 cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [] synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: RO:0002215 GO:0032626 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0001044 name: effector CD4-positive, alpha-beta T cell def: "A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] synonym: "effector CD4+ T cell" BROAD [] synonym: "effector CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: lacks_plasma_membrane_part PR:000001203 intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 GO:0042105 intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002104 PR:000001015 [Term] id: CL:0001050 name: effector CD8-positive, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive." [] synonym: "effector CD8+ T cell" BROAD [] synonym: "effector CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001203 intersection_of: RO:0002104 GO:0042105 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000025402 [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Th1/Th17 CD4+ T cell" BROAD [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 intersection_of: lacks_plasma_membrane_part PR:000001207 [Term] id: CL:0001052 name: CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" EXACT [] synonym: "non-Tc1/Tc17 CD8+ T cell" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: lacks_plasma_membrane_part PR:000001202 intersection_of: lacks_plasma_membrane_part PR:000001207 [Term] id: CL:0001053 name: IgD-negative memory B cell def: "A memory B cell that lacks expression of surface IgD." [] synonym: "IgD- memory B cell" EXACT [] is_a: CL:0000787 ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 [Term] id: CL:0001054 name: CD14-positive monocyte def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [] synonym: "monocyte" NARROW [] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: RO:0002104 PR:000001889 [Term] id: CL:0001055 name: CD14-positive, CD16-low monocyte def: "An intermediate monocyte that is CD14-positive and with low amounts of CD16." [] synonym: "intermediate monocyte, human" EXACT [] is_a: CL:0001054 ! CD14-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0002393 ! intermediate monocyte intersection_of: RO:0002104 PR:000001889 intersection_of: RO:0015016 PR:000001483 [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [] synonym: "CFU-GEMM" RELATED [] synonym: "CFU-S" RELATED [] synonym: "CMP" RELATED [] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [] synonym: "myeloid stem cell" RELATED [] synonym: "pluripotent stem cell (bone marrow)" RELATED [] is_a: CL:0000049 ! common myeloid progenitor intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: BFO:0000051 PR:000001944 intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000007858 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002215 GO:0002573 intersection_of: RO:0002215 GO:0043011 [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0000053 PATO:0001401 relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell [Term] id: CL:0001065 name: innate lymphoid cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: RO:0002215 GO:0001816 intersection_of: RO:0002215 GO:0045087 [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: RO:0002104 PR:000001945 intersection_of: RO:0002215 GO:0030218 [Term] id: CL:0001067 name: group 1 innate lymphoid cell def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0002215 GO:0032609 [Term] id: CL:0001069 name: group 2 innate lymphoid cell def: "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." [] synonym: "ILC2" EXACT [] synonym: "natural helper cell" EXACT [] synonym: "nuocyte" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0002215 GO:0032634 [Term] id: CL:0001071 name: group 3 innate lymphoid cell def: "An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22." [] synonym: "ILC3" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: BFO:0000051 PR:000003455 [Term] id: CL:0001082 name: immature innate lymphoid cell def: "An innate lyphoid cell with an immature phenotype." [] synonym: "immature ILC" EXACT [] is_a: CL:0001065 ! innate lymphoid cell intersection_of: CL:0001065 ! innate lymphoid cell intersection_of: RO:0000053 PATO:0001501 [Term] id: CL:0001200 name: lymphocyte of B lineage, CD19-positive def: "A lymphocyte of B lineage that is CD19-positive." [] is_a: CL:0000945 ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: RO:0002104 PR:000001002 intersection_of: RO:0002162 NCBITaxon:40674 [Term] id: CL:0001201 name: B cell, CD19-positive def: "A B cell that is CD19-positive." [] synonym: "B lymphocyte, CD19-positive" EXACT [] synonym: "B-cell, CD19-positive" EXACT [] synonym: "B-lymphocyte, CD19-positive" EXACT [] synonym: "CD19+ B cell" EXACT [] synonym: "CD19-positive B cell" EXACT [] is_a: CL:0000236 ! B cell is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive intersection_of: CL:0001200 ! lymphocyte of B lineage, CD19-positive intersection_of: RO:0002104 PR:000001002 intersection_of: RO:0002162 NCBITaxon:40674 intersection_of: RO:0002215 GO:0019724 [Term] id: CL:0001202 name: CD86-positive plasmablast def: "A plasmablast that is CD86-positive." [] synonym: "CD86+ plasmablast" EXACT [] synonym: "CD86-positive, CD20-negative plasmablast" BROAD [] is_a: CL:0000980 ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: RO:0002104 PR:000001412 [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [] synonym: "c- Kit-positive erythroid progenitor cell" EXACT [] is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: lacks_plasma_membrane_part GO:0033001 intersection_of: lacks_plasma_membrane_part PR:000001833 intersection_of: lacks_plasma_membrane_part PR:000001865 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: lacks_plasma_membrane_part PR:000009127 intersection_of: RO:0002104 PR:000001345 intersection_of: RO:0002104 PR:000002065 relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [] is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000001865 relationship: RO:0002202 CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [] is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001206 intersection_of: lacks_plasma_membrane_part PR:000001843 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0015015 GO:0033001 intersection_of: RO:0015015 PR:000001479 relationship: RO:0002202 CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [] is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: lacks_plasma_membrane_part PR:000001460 intersection_of: RO:0002104 PR:000001003 relationship: RO:0002202 CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast def: "A proerythoblast that is CD34-negative and GlyA-negative." [] is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: lacks_plasma_membrane_part PR:000001460 relationship: RO:0002202 CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [] is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: lacks_plasma_membrane_part PR:000001865 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001408 [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [] is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: lacks_plasma_membrane_part PR:000001479 intersection_of: lacks_plasma_membrane_part PR:000001843 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0015016 GO:0033001 [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [] is_a: CL:0000611 ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001867 intersection_of: RO:0015016 PR:000002065 relationship: RO:0002202 CL:0002002 ! Kit-positive granulocyte monocyte progenitor [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [] is_a: CL:0000611 ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001408 intersection_of: RO:0002104 PR:000001865 relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor [Term] id: CL:0002009 name: macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [] synonym: "MDP" EXACT [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030224 intersection_of: RO:0002215 GO:0043011 relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0002010 name: pre-conventional dendritic cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [] is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part GO:0042613 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: lacks_plasma_membrane_part PR:000001083 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001289 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001889 intersection_of: lacks_plasma_membrane_part PR:000002978 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000001013 intersection_of: RO:0002104 PR:000001968 intersection_of: RO:0002104 PR:000002001 relationship: RO:0002202 CL:0001029 ! common dendritic progenitor [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [] synonym: "murine MDP" EXACT [] is_a: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: RO:0002104 PR:000001206 intersection_of: RO:0002104 PR:000002001 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0015015 PR:000002065 relationship: RO:0002202 CL:0002002 ! Kit-positive granulocyte monocyte progenitor [Term] id: CL:0002012 name: Kit-low proerythroblast def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [] is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000002981 intersection_of: RO:0015015 PR:000001945 intersection_of: RO:0015016 PR:000002065 relationship: RO:0002202 CL:0002000 ! Kit-positive erythroid progenitor cell [Term] id: CL:0002013 name: GlyA-positive basophilic erythroblast def: "A basophilic erythroblast that is GlyA-positive." [] is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: RO:0002104 PR:000001460 relationship: RO:0002202 CL:0002004 ! CD34-negative, GlyA-negative proerythroblast [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [] is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0015015 PR:000002981 relationship: RO:0002202 CL:0002012 ! Kit-low proerythroblast [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0015015 PR:000002981 relationship: RO:0002202 CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [] is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: RO:0002104 PR:000001460 intersection_of: RO:0015016 PR:000001945 relationship: RO:0002202 CL:0002013 ! GlyA-positive basophilic erythroblast [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [] is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0015015 PR:000002981 intersection_of: RO:0015016 PR:000001945 relationship: RO:0002202 CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast def: "An erythroblast that is GlyA-positive and CD71-negative." [] is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: lacks_plasma_membrane_part PR:000001945 intersection_of: RO:0002104 PR:000001460 relationship: RO:0002202 CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast [Term] id: CL:0002019 name: Ly-76 high reticulocyte def: "A reticulocyte that is Ly76-high and is Kit-negative." [] is_a: CL:0002422 ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: RO:0015015 PR:000002981 relationship: RO:0002202 CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts [Term] id: CL:0002020 name: GlyA-positive reticulocytes def: "A reticulocyte that is GlyA-positive." [] is_a: CL:0002422 ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: RO:0002104 PR:000001460 relationship: RO:0002202 CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast [Term] id: CL:0002021 name: GlyA-positive erythrocyte def: "An enucleate erythrocyte that is GlyA-positive." [] is_a: CL:0000595 ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: RO:0002104 PR:000001460 relationship: RO:0002202 CL:0002020 ! GlyA-positive reticulocytes [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte def: "An enucleate erythrocyte that is Lyg-76-high." [] is_a: CL:0000595 ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: RO:0015015 PR:000002981 relationship: RO:0002202 CL:0002019 ! Ly-76 high reticulocyte [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [] is_a: CL:0000553 ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001833 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000005178 intersection_of: RO:0015016 PR:000001479 intersection_of: RO:0015016 PR:000001483 relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [] is_a: CL:0000556 ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: RO:0002104 PR:000005178 intersection_of: RO:0002104 PR:000009127 relationship: RO:0002202 CL:0002024 ! Kit-positive megakaryocyte progenitor cell [Term] id: CL:0002028 name: basophil mast progenitor cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [] synonym: "BMCP" EXACT [] is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: BFO:0000051 PR:000005307 intersection_of: BFO:0000051 PR:000007857 intersection_of: BFO:0000051 PR:000007858 intersection_of: lacks_plasma_membrane_part PR:000007431 intersection_of: lacks_plasma_membrane_part PR:000016401 intersection_of: RO:0002104 PR:000001867 intersection_of: RO:0002215 GO:0030221 intersection_of: RO:0002215 GO:0060374 relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [] is_a: CL:0000831 ! mast cell progenitor intersection_of: CL:0000831 ! mast cell progenitor intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001006 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000009143 intersection_of: RO:0015016 PR:000007431 relationship: RO:0002202 CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [] is_a: CL:0000613 ! basophil progenitor cell intersection_of: CL:0000613 ! basophil progenitor cell intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0015015 PR:000007431 relationship: RO:0002202 CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001400 disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: RO:0002202 CL:0002032 ! hematopoietic oligopotent progenitor cell [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [] is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001401 relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell [Term] id: CL:0002033 name: short term hematopoietic stem cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [] synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: lacks_plasma_membrane_part PR:000002001 intersection_of: RO:0002104 PR:000001003 intersection_of: RO:0002104 PR:000001833 relationship: RO:0002202 CL:0002034 ! long term hematopoietic stem cell [Term] id: CL:0002034 name: long term hematopoietic stem cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [] synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: lacks_plasma_membrane_part PR:000002001 intersection_of: RO:0002104 PR:000001833 intersection_of: RO:0015016 PR:000001843 [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001833 intersection_of: lacks_plasma_membrane_part PR:000002001 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000002979 relationship: RO:0002202 CL:0002036 ! Slamf1-positive multipotent progenitor cell [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [] synonym: "KSL cell" EXACT [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: RO:0002104 PR:000001833 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000002979 disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: RO:0002202 CL:0002033 ! short term hematopoietic stem cell [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [] synonym: "memory alpha beta IEL" EXACT [] is_a: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: RO:0002104 PR:000001083 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0002104 PR:000001839 [Term] id: CL:0002038 name: T follicular helper cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [] synonym: "follicular B helper T cell" RELATED [] synonym: "follicular helper T cell" RELATED [] synonym: "follicular helper T-cell" RELATED [] synonym: "follicular T cell" RELATED [] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [] synonym: "T(FH)" EXACT [] synonym: "Tfh" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: BFO:0000051 PR:000003450 intersection_of: lacks_plasma_membrane_part PR:000001203 intersection_of: RO:0002104 PR:000001209 intersection_of: RO:0002104 PR:000001860 intersection_of: RO:0002104 PR:000001919 intersection_of: RO:0002215 GO:0045830 intersection_of: RO:0002215 GO:0051024 relationship: RO:0002202 CL:0000896 ! activated CD4-positive, alpha-beta T cell [Term] id: CL:0002039 name: immature NK T cell stage I def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [] is_a: CL:0000914 ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: lacks_plasma_membrane_part PR:000001307 intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: RO:0015015 PR:000001932 intersection_of: RO:0015016 PR:000001004 intersection_of: RO:0015016 PR:000025402 relationship: RO:0002202 CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0002040 name: immature NK T cell stage II def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [] synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: lacks_plasma_membrane_part PR:000001307 intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: RO:0015016 PR:000001932 relationship: RO:0002202 CL:0002039 ! immature NK T cell stage I [Term] id: CL:0002041 name: immature NK T cell stage III def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0015016 PR:000001008 intersection_of: RO:0015016 PR:000001932 relationship: RO:0002202 CL:0002040 ! immature NK T cell stage II [Term] id: CL:0002042 name: immature NK T cell stage IV def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0015015 PR:000001008 intersection_of: RO:0015016 PR:000001932 relationship: RO:0002202 CL:0002041 ! immature NK T cell stage III [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [] is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001015 intersection_of: lacks_plasma_membrane_part PR:000001408 intersection_of: lacks_plasma_membrane_part PR:000001843 intersection_of: RO:0002104 PR:000001003 relationship: RO:0002202 CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [] is_a: CL:0002028 ! basophil mast progenitor cell intersection_of: CL:0002028 ! basophil mast progenitor cell intersection_of: lacks_plasma_membrane_part PR:000002065 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001479 intersection_of: RO:0002104 PR:000001483 intersection_of: RO:0015015 PR:000009143 [Term] id: CL:0002045 name: fraction A pre-pro B cell def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [] synonym: "fraction A" BROAD [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: lacks_plasma_membrane_part PR:000002039 intersection_of: lacks_plasma_membrane_part PR:000002980 intersection_of: RO:0002104 PR:000001015 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002104 PR:000002037 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0015016 PR:000001932 [Term] id: CL:0002047 name: fraction B precursor B cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [] synonym: "Fr. B" BROAD [] synonym: "Fraction B" BROAD [] is_a: CL:0002400 ! fraction B/C precursor B cell intersection_of: CL:0002400 ! fraction B/C precursor B cell intersection_of: lacks_plasma_membrane_part PR:000002039 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001932 relationship: RO:0002202 CL:0002045 ! fraction A pre-pro B cell [Term] id: CL:0002049 name: fraction C precursor B cell def: "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [] synonym: "Fraction C" RELATED [] is_a: CL:0002400 ! fraction B/C precursor B cell intersection_of: CL:0002400 ! fraction B/C precursor B cell intersection_of: BFO:0000051 PR:000001858 intersection_of: BFO:0000051 PR:000001859 intersection_of: has_not_completed GO:0071707 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002039 intersection_of: RO:0002104 PR:000003457 intersection_of: RO:0002104 PR:000003460 relationship: RO:0002202 CL:0002047 ! fraction B precursor B cell [Term] id: CL:0002050 name: fraction C' precursor B cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [] synonym: "Fr. C'" BROAD [] synonym: "Fraction C-prime" BROAD [] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: RO:0002104 GO:0035369 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001380 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002104 PR:000002039 intersection_of: RO:0015015 PR:000001932 relationship: RO:0002202 CL:0002049 ! fraction C precursor B cell [Term] id: CL:0002052 name: fraction D precursor B cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [] synonym: "Fr. D" BROAD [] synonym: "fraction D pre-B cell" EXACT [] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_not_completed GO:0071708 intersection_of: lacks_plasma_membrane_part GO:0035369 intersection_of: RO:0002104 PR:000001002 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001380 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002037 intersection_of: RO:0002104 PR:000002039 intersection_of: RO:0015016 PR:000001879 relationship: RO:0002202 CL:0002050 ! fraction C' precursor B cell [Term] id: CL:0002054 name: fraction E immature B cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [] is_a: CL:0000816 ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: lacks_plasma_membrane_part PR:000001869 intersection_of: RO:0002104 PR:000001002 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002037 intersection_of: RO:0015016 PR:000001879 relationship: RO:0002202 CL:0002052 ! fraction D precursor B cell [Term] id: CL:0002056 name: fraction F mature B cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001879 intersection_of: lacks_plasma_membrane_part PR:000001880 intersection_of: lacks_plasma_membrane_part PR:000002037 intersection_of: RO:0002104 GO:0071738 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002104 PR:000001338 relationship: RO:0002202 CL:0002054 ! fraction E immature B cell [Term] id: CL:0002058 name: Gr1-low non-classical monocyte def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [] is_a: CL:0000875 ! non-classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: lacks_plasma_membrane_part PR:000001014 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001206 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0015016 PR:000001199 intersection_of: RO:0015016 PR:000002980 relationship: RO:0002202 CL:0002398 ! Gr1-positive, CD43-positive monocyte [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: RO:0002104 PR:000001084 [Term] id: CL:0002062 name: type I pneumocyte def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0007585 [Term] id: CL:0002063 name: type II pneumocyte def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0032940 intersection_of: RO:0002215 GO:0043129 relationship: RO:0002202 CL:4040003 ! fetal pre-type II pneumocyte [Term] id: CL:0002067 name: type A enteroendocrine cell def: "An enteroendocrine cell that produces glucagon." [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: RO:0002215 GO:0070091 [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [] synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [] synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] is_a: CL:0000584 ! enterocyte is_a: CL:0002253 ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001278 [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [] synonym: "cardiac pacemaker cell" EXACT [] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [] is_a: CL:0000066 ! epithelial cell relationship: RO:0002202 CL:0000223 ! endodermal cell [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000221 ! ectodermal cell [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [] synonym: "epithelial mesenchymal cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000222 ! mesodermal cell [Term] id: CL:0002085 name: tanycyte def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [] synonym: "stretch cell" EXACT [] is_a: CL:0000683 ! ependymoglial cell [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [] is_a: CL:0000746 ! cardiac muscle cell [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [] synonym: "agranular leukocyte" EXACT [] is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: lacks_part GO:0030141 [Term] id: CL:0002088 name: interstitial cell of Cajal def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [] synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [] is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: RO:0002215 GO:0043134 [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [] is_a: CL:0001035 ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: BFO:0000050 UBERON:0002371 [Term] id: CL:0002097 name: cortical cell of adrenal gland def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [] synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: BFO:0000050 UBERON:0001235 [Term] id: CL:0002098 name: regular cardiac myocyte def: "A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval." [] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] is_a: CL:0000746 ! cardiac muscle cell [Term] id: CL:0002101 name: CD38-positive naive B cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: RO:0002104 PR:000001408 [Term] id: CL:0002102 name: CD38-negative naive B cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: lacks_plasma_membrane_part PR:000001408 [Term] id: CL:0002103 name: IgG-positive double negative memory B cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: RO:0002104 GO:0071735 [Term] id: CL:0002104 name: IgG-negative double negative memory B cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 [Term] id: CL:0002105 name: CD38-positive IgG memory B cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: RO:0002104 PR:000001408 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [] is_a: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: RO:0002104 GO:0071738 [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [] is_a: CL:0001053 ! IgD-negative memory B cell is_a: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 [Term] id: CL:0002108 name: CD38-negative IgG memory B cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [] is_a: CL:0000979 ! IgG memory B cell is_a: CL:0001053 ! IgD-negative memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 intersection_of: lacks_plasma_membrane_part PR:000001408 [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: RO:0002104 PR:000001014 [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [] is_a: CL:0002101 ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: RO:0015016 PR:000001014 [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: RO:0002104 PR:000001014 [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: RO:0015016 PR:000001014 [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: RO:0002104 PR:000001408 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: RO:0002104 PR:000001014 [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [] is_a: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: RO:0015016 PR:000001014 [Term] id: CL:0002117 name: IgG-negative class switched memory B cell def: "A class switched memory B cell that lacks IgG on the cell surface." [] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [] is_a: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001408 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001932 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [] is_a: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001932 [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: RO:0002104 PR:000001014 [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [] is_a: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: RO:0015016 PR:000001014 [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: RO:0002104 PR:000001963 intersection_of: RO:0002215 GO:0032609 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [] synonym: "gammadelta-17 cells" EXACT [] is_a: CL:0000800 ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: BFO:0000051 PR:000003455 intersection_of: lacks_plasma_membrane_part PR:000001963 intersection_of: RO:0002215 GO:0032620 intersection_of: RO:0002353 GO:0030217 relationship: RO:0002202 CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [] is_a: CL:0000799 ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000799 ! immature gamma-delta T cell intersection_of: BFO:0000050 UBERON:0002370 intersection_of: RO:0002104 PR:000001380 intersection_of: RO:0002104 PR:000001919 intersection_of: RO:0015015 PR:000001307 intersection_of: RO:0015015 PR:000001318 intersection_of: RO:0015015 PR:000001932 intersection_of: RO:0015016 PR:000001083 intersection_of: RO:0015016 PR:000001839 [Term] id: CL:0002127 name: innate effector T cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [] is_a: CL:0000911 ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0045087 [Term] id: CL:0002129 name: regular atrial cardiac myocyte def: "Regular cardiac myocyte of a cardiac atrium." [] synonym: "atrial cardiac muscle cell" EXACT [] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] is_a: CL:0002098 ! regular cardiac myocyte [Term] id: CL:0002131 name: regular ventricular cardiac myocyte def: "Regular cardiac myocyte of a cardiac ventricle." [] synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [] synonym: "ventricular myocyte" EXACT [] is_a: CL:0002098 ! regular cardiac myocyte [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [] synonym: "ovarian stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0000992 [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0001473 intersection_of: RO:0002202 CL:0005022 ! vascular lymphangioblast [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [] synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] is_a: CL:0000115 ! endothelial cell [Term] id: CL:0002140 name: acinar cell of sebaceous gland def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [] synonym: "sebocyte" BROAD [] is_a: CL:0000317 ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000317 ! sebum secreting cell intersection_of: BFO:0000050 UBERON:0003487 [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell is_a: CL:4030034 ! respiratory ciliated cell relationship: RO:0002202 CL:0002209 ! intermediate epitheliocyte [Term] id: CL:0002148 name: dental pulp cell def: "A cell found within the dental pulp." [] is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: BFO:0000050 UBERON:0001754 [Term] id: CL:0002149 name: epithelial cell of uterus def: "An epithelial cell of the uterus." [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0000995 [Term] id: CL:0002153 name: corneocyte def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000311 ! keratin accumulating cell relationship: BFO:0000050 UBERON:0002027 relationship: RO:0002202 CL:0000312 ! keratinocyte [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [] is_a: CL:0002077 ! ecto-epithelial cell [Term] id: CL:0002167 name: olfactory epithelial cell def: "A specialized cell involved in sensory perception of smell." [] is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050911 [Term] id: CL:0002174 name: follicular cell of ovary def: "A cell within the follicle of an ovary." [] is_a: CL:0000500 ! follicular epithelial cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0002178 name: epithelial cell of stomach def: "An epithelial cell found in the lining of the stomach." [] is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000945 [Term] id: CL:0002187 name: basal cell of epidermis def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [] is_a: CL:0000312 ! keratinocyte is_a: CL:0000646 ! basal cell is_a: CL:0011026 ! progenitor cell is_a: CL:1000428 ! stem cell of epidermis intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0001003 [Term] id: CL:0002188 name: glomerular endothelial cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [] is_a: CL:0000115 ! endothelial cell is_a: CL:0000666 ! fenestrated cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000074 [Term] id: CL:0002191 name: granulocytopoietic cell def: "A cell involved in the formation of a granulocyte." [] is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 [Term] id: CL:0002192 name: metamyelocyte def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [] is_a: CL:0002191 ! granulocytopoietic cell relationship: RO:0002202 CL:0002193 ! myelocyte [Term] id: CL:0002193 name: myelocyte def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [] is_a: CL:0002191 ! granulocytopoietic cell relationship: RO:0002202 CL:0000836 ! promyelocyte [Term] id: CL:0002194 name: monopoietic cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [] is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 [Term] id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [] synonym: "HpSC" RELATED [] is_a: CL:0000048 ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0002107 [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree def: "An epithelial cell of the tracheobronchial tree." [] is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007196 [Term] id: CL:0002209 name: intermediate epitheliocyte def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000965 [Term] id: CL:0002231 name: epithelial cell of prostate def: "An epithelial cell of the prostate." [] synonym: "prostate epithelial cell" EXACT [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0002367 [Term] id: CL:0002233 name: epithelial cell of prostatic acinus def: "An epithelial cell of the prostatic acinus." [] synonym: "acinar epithelial cell of prostate" EXACT [] is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: BFO:0000050 UBERON:0004179 [Term] id: CL:0002234 name: basal cell of prostatic acinus def: "A cell of the basal layer of the epithelium in the prostatic acinus." [] synonym: "basal epithelial cell of prostatic acinus" EXACT [] is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: BFO:0000050 UBERON:0004179 [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002371 [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001555 [Term] id: CL:0002252 name: epithelial cell of esophagus def: "An epithelial cell of the esophagus." [] is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001043 [Term] id: CL:0002253 name: epithelial cell of large intestine def: "An epithelial cell of the large intestine." [] synonym: "epithelial cell of colon" RELATED [] is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: BFO:0000050 UBERON:0000059 [Term] id: CL:0002254 name: epithelial cell of small intestine def: "An epithelial cell of the small intestine." [] is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: BFO:0000050 UBERON:0002108 [Term] id: CL:0002257 name: epithelial cell of thyroid gland def: "An epithelial cell of thyroid gland." [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0002046 [Term] id: CL:0002260 name: epithelial cell of parathyroid gland def: "An epithelial cell of the parathyroid gland." [] is_a: CL:0002076 ! endo-epithelial cell is_a: CL:1001593 ! parathyroid glandular cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0001132 [Term] id: CL:0002264 name: type A cell of stomach def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [] is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 [Term] id: CL:0002265 name: type D cell of colon def: "A D cell located in the colon." [] synonym: "colon D-cell" EXACT [] synonym: "colonic delta cell" EXACT [] synonym: "delta cell of colon" EXACT [] is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0009042 ! enteroendocrine cell of colon intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:0002266 name: type D cell of small intestine def: "A type D cell of the small intestine." [] synonym: "delta cell of small intestine" EXACT [] synonym: "small intestine D-cell" EXACT [] synonym: "small intestine delta cell" EXACT [] is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:0009006 ! enteroendocrine cell of small intestine intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0002108 [Term] id: CL:0002267 name: type D cell of stomach def: "A type D cell found in the stomach." [] synonym: "delta cell of stomach" EXACT [] synonym: "stomach D-cell" EXACT [] synonym: "stomach delta cell" EXACT [] is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000502 ! type D enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 [Term] id: CL:0002274 name: histamine secreting cell def: "A cell type that secretes histamine." [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001821 [Term] id: CL:0002275 name: pancreatic PP cell def: "A PP cell located in the islets of the pancreas." [] synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] is_a: CL:0000696 ! PP cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0000696 ! PP cell intersection_of: BFO:0000050 UBERON:0000006 intersection_of: BFO:0000050 UBERON:0001264 [Term] id: CL:0002293 name: epithelial cell of thymus def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0002370 [Term] id: CL:0002301 name: type B synovial cell def: "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles." [] synonym: "fibroblast-like synoviocyte" EXACT [] synonym: "synovial fibroblast" EXACT [] is_a: CL:0000214 ! synovial cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002018 relationship: RO:0002215 GO:0030213 relationship: RO:0003000 UBERON:0001090 [Term] id: CL:0002305 name: epithelial cell of distal tubule def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [] synonym: "kidney distal tubule epithelial cell" EXACT [] is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004135 relationship: BFO:0000050 UBERON:0004135 [Term] id: CL:0002306 name: epithelial cell of proximal tubule def: "An epithelial cell of the proximal tubule of the kidney." [] synonym: "kidney proximal tubule epithelial cell" EXACT [] is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004134 relationship: BFO:0000050 UBERON:0004134 [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [] synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: BFO:0000050 UBERON:0002367 intersection_of: RO:0002215 GO:0046879 [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001016 [Term] id: CL:0002320 name: connective tissue cell def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002384 [Term] id: CL:0002321 name: embryonic cell (metazoa) def: "A cell of the embryo." [] is_a: CL:0000000 ! cell [Term] id: CL:0002322 name: embryonic stem cell def: "A stem cell of embryonic origin." [] synonym: "ESC" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0002323 name: amniocyte def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [] is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: RO:0001025 UBERON:0000173 [Term] id: CL:0002325 name: lactocyte def: "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." [] synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "lactaction-associated mammary epithelial cell" EXACT [] synonym: "lactation-derived mammary cell" EXACT [] synonym: "LMC" RELATED [] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] synonym: "mammary alveolar cell" BROAD [] synonym: "mammary alveolar epithelial cell" EXACT [] synonym: "mammary gland alveolar epithelial cell" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0003214 relationship: RO:0002202 CL:4033057 ! luminal adaptive secretory precursor cell of mammary gland [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [] synonym: "mature luminal cell" BROAD [] is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell relationship: RO:0002202 CL:0009116 ! progenitor cell of mammary luminal epithelium [Term] id: CL:0002327 name: mammary gland epithelial cell def: "An epithelial cell of the mammary gland." [] synonym: "breast epithelial cell" EXACT [] synonym: "mammary epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001911 [Term] id: CL:0002328 name: bronchial epithelial cell def: "An epithelial cell of the bronchus." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002185 relationship: BFO:0000050 UBERON:0002031 [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree [Term] id: CL:0002332 name: ciliated cell of the bronchus def: "A ciliated cell of the bronchus." [] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002185 [Term] id: CL:0002333 name: neural crest derived adipocyte def: "An adipocyte derived from a neural crest cell." [] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell relationship: RO:0002202 CL:0000005 ! fibroblast neural crest derived [Term] id: CL:0002334 name: preadipocyte def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [] is_a: CL:0000057 ! fibroblast [Term] id: CL:0002335 name: brown preadipocyte def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [] is_a: CL:0002334 ! preadipocyte [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell, human def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." [] synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: RO:0002104 PR:000001024 intersection_of: RO:0002104 PR:000001381 intersection_of: RO:0002104 PR:000001874 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002162 NCBITaxon:9606 relationship: RO:0002202 CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell, human [Term] id: CL:0002339 name: prostate stem cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0002367 [Term] id: CL:0002341 name: basal cell of prostate epithelium def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [] is_a: CL:0002231 ! epithelial cell of prostate [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell, human def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [] synonym: "p-NK" RELATED [] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001003 intersection_of: lacks_plasma_membrane_part PR:000001024 intersection_of: RO:0002104 PR:000001381 intersection_of: RO:0002104 PR:000001874 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002162 NCBITaxon:9606 [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [] is_a: CL:0000823 ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001008 intersection_of: RO:0002104 PR:000002977 intersection_of: RO:0002162 NCBITaxon:10090 [Term] id: CL:0002350 name: endocardial cell def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [] synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002165 [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0011026 ! progenitor cell [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000922 [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [] is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: lacks_plasma_membrane_part PR:000001308 intersection_of: lacks_plasma_membrane_part PR:000001896 intersection_of: RO:0002104 GO:0042611 intersection_of: RO:0002104 PR:000001006 intersection_of: RO:0002104 PR:000001833 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002037 intersection_of: RO:0002104 PR:000002979 relationship: BFO:0000050 UBERON:0002107 [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: lacks_plasma_membrane_part GO:0042611 intersection_of: lacks_plasma_membrane_part PR:000001006 intersection_of: lacks_plasma_membrane_part PR:000002979 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002037 relationship: BFO:0000050 UBERON:0001040 [Term] id: CL:0002355 name: primitive red blood cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: BFO:0000050 UBERON:0000922 intersection_of: BFO:0000051 PR:000008467 intersection_of: BFO:0000051 PR:000008857 intersection_of: RO:0000053 PATO:0000586 relationship: RO:0002202 CL:0002361 ! primitive erythroid progenitor [Term] id: CL:0002356 name: primitive reticulocyte def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [] synonym: "megalocyte" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0000053 PATO:0000586 intersection_of: RO:0002202 CL:0002355 ! primitive red blood cell [Term] id: CL:0002357 name: fetal derived definitive erythrocyte def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [] synonym: "macrocyte" EXACT [] is_a: CL:0000595 ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: BFO:0000050 UBERON:0000922 intersection_of: BFO:0000051 PR:000008857 relationship: RO:0002202 CL:0002353 ! fetal liver hematopoietic progenitor cell [Term] id: CL:0002358 name: pyrenocyte def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [] is_a: CL:0002417 ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0000053 PATO:0000587 intersection_of: RO:0002202 CL:0002355 ! primitive red blood cell [Term] id: CL:0002359 name: placental hematopoietic stem cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [] is_a: CL:0002352 ! gestational hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:0002361 name: primitive erythroid progenitor def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: RO:0002104 PR:000009127 relationship: RO:0002202 CL:0002418 ! hemangioblast [Term] id: CL:0002362 name: cerebellar granule cell precursor def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [] synonym: "GCP" RELATED [] synonym: "granule cell precursor" BROAD [] synonym: "granule cell progenitor" BROAD [] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) relationship: BFO:0000050 UBERON:0009841 [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! fibroblast neural crest derived intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001777 relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0002367 name: trabecular meshwork cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0005969 [Term] id: CL:0002368 name: respiratory epithelial cell def: "An endo-epithelial cell of the respiratory tract." [] synonym: "airway epithelial cell" EXACT [] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: BFO:0000050 UBERON:0000065 [Term] id: CL:0002369 name: fungal spore def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [] is_a: CL:0000521 ! fungal cell [Term] id: CL:0002370 name: respiratory goblet cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [] synonym: "respiratory mucosa goblet cells" EXACT [] is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000065 relationship: BFO:0000050 UBERON:0004802 [Term] id: CL:0002372 name: myotube def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] is_a: CL:0000187 ! muscle cell is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 intersection_of: RO:0000053 PATO:0001908 intersection_of: RO:0000053 PATO:0002478 [Term] id: CL:0002374 name: ear hair cell def: "A hair cell of the ear that contains the organs of balance and hearing." [] synonym: "ear receptor cell" EXACT [] is_a: CL:0000855 ! sensory hair cell intersection_of: CL:0000855 ! sensory hair cell intersection_of: BFO:0000050 UBERON:0001690 [Term] id: CL:0002375 name: Schwann cell precursor def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0002377 name: immature Schwann cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [] synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: RO:0002202 CL:0002375 ! Schwann cell precursor [Term] id: CL:0002385 name: blastoconidium def: "An oblong or round asexual spore formed from conidial chains." [] synonym: "blastospore" RELATED [] is_a: CL:0000606 ! macroconidium [Term] id: CL:0002387 name: arthroconidium def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [] synonym: "arthrospore" RELATED [] is_a: CL:0000606 ! macroconidium [Term] id: CL:0002393 name: intermediate monocyte def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_not_completed GO:0030224 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001199 intersection_of: lacks_plasma_membrane_part PR:000001289 relationship: RO:0002202 CL:0000860 ! classical monocyte [Term] id: CL:0002395 name: Gr1-high classical monocyte def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [] is_a: CL:0000860 ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: lacks_plasma_membrane_part PR:000001014 intersection_of: lacks_plasma_membrane_part PR:000001206 intersection_of: lacks_plasma_membrane_part PR:000001879 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0015015 PR:000002980 [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte def: "A patrolling monocyte that is CD14-low and CD16-positive." [] synonym: "non-classical monocyte, human" EXACT [] is_a: CL:0000875 ! non-classical monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: RO:0002104 PR:000001483 intersection_of: RO:0015016 PR:000001889 relationship: RO:0002202 CL:0002397 ! CD14-positive, CD16-positive monocyte [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [] synonym: "CD16+ monocyte" EXACT [] is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: lacks_plasma_membrane_part PR:000001199 intersection_of: RO:0002104 PR:000001483 [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002104 PR:000002062 intersection_of: RO:0002104 PR:000002980 relationship: RO:0002202 CL:0002395 ! Gr1-high classical monocyte [Term] id: CL:0002400 name: fraction B/C precursor B cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: lacks_plasma_membrane_part GO:0071753 intersection_of: RO:0002104 PR:000001002 intersection_of: RO:0002104 PR:000001879 intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0002104 PR:000002037 [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [] synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: RO:0002202 CL:0002218 ! immature dendritic epithelial T cell precursor [Term] id: CL:0002402 name: Peyer's patch B cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell is_a: CL:0009014 ! Peyer's patch lymphocyte intersection_of: CL:0000785 ! mature B cell intersection_of: BFO:0000050 UBERON:0001211 intersection_of: lacks_plasma_membrane_part PR:000001839 intersection_of: lacks_plasma_membrane_part PR:000001879 intersection_of: lacks_plasma_membrane_part PR:000002037 intersection_of: RO:0002104 GO:0071753 intersection_of: RO:0002104 PR:000001014 intersection_of: RO:0002104 PR:000001289 intersection_of: RO:0002104 PR:000001338 [Term] id: CL:0002404 name: fetal thymocyte def: "A thymocyte found in the fetal thymus." [] is_a: CL:0000893 ! thymocyte [Term] id: CL:0002405 name: gamma-delta thymocyte def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000025402 intersection_of: RO:0002104 GO:0042106 [Term] id: CL:0002410 name: pancreatic stellate cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [] synonym: "pancreas stellate cell" EXACT [] synonym: "PaSC" EXACT [] is_a: CL:0000057 ! fibroblast relationship: BFO:0000050 UBERON:0001264 [Term] id: CL:0002417 name: primitive erythroid lineage cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [] is_a: CL:0000764 ! erythroid lineage cell [Term] id: CL:0002418 name: hemangioblast def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [] is_a: CL:0000222 ! mesodermal cell relationship: RO:0002202 CL:0002354 ! yolk sac hematopoietic stem cell [Term] id: CL:0002419 name: mature T cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042101 intersection_of: RO:0002353 GO:0045058 [Term] id: CL:0002420 name: immature T cell def: "A T cell that has not completed T cell selection." [] synonym: "immature T-cell" EXACT [] is_a: CL:0000084 ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [] is_a: CL:0000558 ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: RO:0000053 PATO:0002505 [Term] id: CL:0002422 name: enucleated reticulocyte def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000558 ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: BFO:0000051 GO:0005840 intersection_of: RO:0000053 PATO:0001405 [Term] id: CL:0002423 name: DN2a thymocyte def: "A DN2 thymocyte that is Kit-hi." [] is_a: CL:0000806 ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: RO:0015015 PR:000002065 [Term] id: CL:0002424 name: DN2b thymocyte def: "A DN2 thymocyte that is Kit-low." [] is_a: CL:0000806 ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: RO:0015016 PR:000002065 relationship: RO:0002202 CL:0002423 ! DN2a thymocyte [Term] id: CL:0002425 name: early T lineage precursor def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [] synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: lacks_plasma_membrane_part PR:000001380 intersection_of: RO:0002104 PR:000001307 intersection_of: RO:0002104 PR:000001869 intersection_of: RO:0002104 PR:000002065 [Term] id: CL:0002427 name: resting double-positive thymocyte def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000053 PATO:0000587 [Term] id: CL:0002428 name: double-positive blast def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000053 PATO:0000586 intersection_of: RO:0000056 GO:0008283 relationship: RO:0002202 CL:0002427 ! resting double-positive thymocyte [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0015016 GO:0042105 relationship: RO:0002202 CL:0002428 ! double-positive blast [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [] synonym: "T.4int8+.Th" EXACT [] synonym: "T_4int8+_Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0015015 GO:0042105 intersection_of: RO:0015016 PR:000001004 relationship: RO:0002202 CL:0002429 ! CD69-positive double-positive thymocyte [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." [] synonym: "T.4+8int.Th" EXACT [] synonym: "T_4+8int_Th" EXACT [] is_a: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: RO:0000056 GO:0043368 intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0015015 GO:0042105 intersection_of: RO:0015016 PR:000025402 relationship: RO:0002202 CL:0002429 ! CD69-positive double-positive thymocyte [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0015015 GO:0042105 relationship: RO:0002202 CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0015015 GO:0042105 relationship: RO:0002202 CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [] synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001932 intersection_of: RO:0015015 GO:0042105 relationship: RO:0002202 CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte def: "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: RO:0002104 PR:000001343 intersection_of: RO:0015015 GO:0042105 relationship: RO:0002202 CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0015015 GO:0042105 intersection_of: RO:0015016 PR:000001932 relationship: RO:0002202 CL:0002432 ! CD24-positive, CD4 single-positive thymocyte [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0015015 GO:0042105 intersection_of: RO:0015016 PR:000001932 relationship: RO:0002202 CL:0002434 ! CD24-positive, CD8 single-positive thymocyte [Term] id: CL:0002453 name: oligodendrocyte precursor cell def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [] synonym: "O-2A/OPC" RELATED [] synonym: "O2A/OPC" RELATED [] synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD [] synonym: "oligodendrocyte/type-2 astrocyte progenitor cell" BROAD [] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000339 ! glioblast (sensu Vertebrata) relationship: RO:0002215 GO:0030154 [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 [Term] id: CL:0002455 name: CD8_alpha-negative plasmacytoid dendritic cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002104 PR:000001004 [Term] id: CL:0002456 name: CD8_alpha-positive plasmacytoid dendritic cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: RO:0002104 PR:000001004 intersection_of: RO:0002104 PR:000001084 [Term] id: CL:0002457 name: epidermal Langerhans cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [] is_a: CL:0000453 ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: RO:0001025 UBERON:0001003 intersection_of: RO:0002104 GO:0042613 intersection_of: RO:0002104 PR:000001012 intersection_of: RO:0002104 PR:000001014 [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001084 [Term] id: CL:0002462 name: adipose dendritic cell def: "A F4/80-negative dendritic cell located in adipose tissue." [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0001013 intersection_of: lacks_plasma_membrane_part PR:000001813 relationship: RO:0002202 CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-positive." [] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001968 [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-negative." [] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001968 [Term] id: CL:0002465 name: CD11b-positive dendritic cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: lacks_plasma_membrane_part PR:000001013 intersection_of: RO:0015015 PR:000002980 [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: RO:0002104 PR:000001013 intersection_of: RO:0015016 PR:000002980 [Term] id: CL:0002469 name: MHC-II-negative classical monocyte def: "Gr1-high monocyte that lacks MHC-II receptor complex." [] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 [Term] id: CL:0002470 name: MHC-II-positive classical monocyte def: "Gr1-high monocyte that has a MHC-II receptor complex." [] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: RO:0002104 GO:0042613 [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: RO:0015016 GO:0042613 [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: RO:0015015 GO:0042613 [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [] is_a: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: lacks_plasma_membrane_part PR:000001013 intersection_of: RO:0002104 PR:000001813 intersection_of: RO:0015015 PR:000001012 [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [] is_a: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: RO:0002104 PR:000001013 intersection_of: RO:0002104 PR:000001813 intersection_of: RO:0015015 PR:000001012 [Term] id: CL:0002476 name: bone marrow macrophage def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [] synonym: "MF.BM" RELATED [] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0010004 ! mononuclear cell of bone marrow intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: lacks_plasma_membrane_part PR:000001014 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000002980 intersection_of: RO:0002104 PR:000001813 intersection_of: RO:0002104 PR:000002062 relationship: BFO:0000050 UBERON:0002371 [Term] id: CL:0002477 name: adipose macrophage def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0002104 PR:000001006 intersection_of: RO:0002104 PR:000001013 intersection_of: RO:0002104 PR:000001968 [Term] id: CL:0002478 name: F4/80-negative adipose macrophage def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: lacks_plasma_membrane_part PR:000001813 intersection_of: RO:0002104 GO:0042613 [Term] id: CL:0002479 name: F4/80-positive adipose macrophage def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: lacks_plasma_membrane_part GO:0042613 intersection_of: RO:0002104 PR:000001813 [Term] id: CL:0002483 name: hair follicle melanocyte def: "A melanocyte that produces pigment within the hair follicle." [] is_a: CL:0000148 ! melanocyte is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002073 [Term] id: CL:0002484 name: epithelial melanocyte def: "A melanocyte that produces pigment in the epithelium." [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0000483 [Term] id: CL:0002485 name: retinal melanocyte def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0000966 [Term] id: CL:0002488 name: trophoblast giant cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0000586 intersection_of: RO:0002215 GO:0001974 [Term] id: CL:0002489 name: double negative thymocyte def: "A thymocyte that lacks expression of CD4 and CD8." [] synonym: "CD4-CD8- T cell" EXACT [] synonym: "double negative T cell" EXACT [] is_a: CL:0000893 ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000025402 [Term] id: CL:0002491 name: auditory epithelial cell def: "A specialized cell involved in auditory sensory perception." [] is_a: CL:0000098 ! sensory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050910 [Term] id: CL:0002494 name: cardiocyte def: "A cell located in the heart, including both muscle and non muscle cells." [] synonym: "heart cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0007100 [Term] id: CL:0002496 name: intraepithelial lymphocyte def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0001025 UBERON:0001277 intersection_of: RO:0002215 GO:0002385 [Term] id: CL:0002499 name: spongiotrophoblast cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [] synonym: "spongiotrophoblast" EXACT [] is_a: CL:0000351 ! trophoblast cell relationship: BFO:0000050 UBERON:0004021 [Term] id: CL:0002504 name: enteric smooth muscle cell def: "A smooth muscle cell of the intestine." [] synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0000160 [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001004 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: RO:0002104 GO:0042613 intersection_of: RO:0002104 PR:000001293 [Term] id: CL:0002518 name: kidney epithelial cell def: "An epithelial cell of the kidney." [] is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002113 [Term] id: CL:0002520 name: nephrocyte def: "An insect excretory cell that regulates hemolymph composition by filtration and filtrate endocytosis." [] is_a: CL:0002522 ! renal filtration cell relationship: RO:0002160 NCBITaxon:50557 [Term] id: CL:0002522 name: renal filtration cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [] is_a: CL:0000424 ! excretory cell relationship: BFO:0000050 UBERON:0001008 [Term] id: CL:0002523 name: mesonephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [] synonym: "mesonephric glomerular visceral epithelial cell" EXACT [] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0000080 [Term] id: CL:0002524 name: disseminated nephrocyte def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [] is_a: CL:0002520 ! nephrocyte [Term] id: CL:0002525 name: metanephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [] synonym: "metanephric glomerular visceral epithelial cell" EXACT [] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0000081 [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [] synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: RO:0002104 PR:000001483 intersection_of: RO:0002215 GO:0032640 [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: RO:0015016 GO:0042613 intersection_of: RO:0015016 PR:000001412 intersection_of: RO:0015016 PR:000001438 [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: RO:0002104 PR:000001310 intersection_of: RO:0015015 GO:0042613 intersection_of: RO:0015015 PR:000001412 intersection_of: RO:0015015 PR:000001438 relationship: RO:0002202 CL:0002533 ! immature CD16-positive myeloid dendritic cell [Term] id: CL:0002535 name: epithelial cell of cervix def: "An epithelial cell of the cervix." [] synonym: "cervical canal epithelial cell" EXACT [] synonym: "cervical canal of uterus epithelial cell" EXACT [] synonym: "cervix epithelial cell" EXACT [] synonym: "cervix of uterus epithelial cell" EXACT [] synonym: "epithelial cell of cervical canal" EXACT [] synonym: "epithelial cell of cervical canal of uterus" EXACT [] synonym: "epithelial cell of cervix of uterus" EXACT [] synonym: "epithelial cell of neck of uterus" EXACT [] synonym: "epithelial cell of uterine cervix" EXACT [] synonym: "neck of uterus epithelial cell" EXACT [] synonym: "uterine cervix epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000002 relationship: BFO:0000050 UBERON:0004801 [Term] id: CL:0002539 name: aortic smooth muscle cell def: "A smooth muscle cell of the aorta." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0004178 [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow def: "A mesenchymal stem cell that is part of the bone marrow." [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002371 [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell def: "A mesenchymal stem cell of the chorionic membrane." [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0003124 [Term] id: CL:0002543 name: vein endothelial cell def: "An endothelial cell that is part of the vein." [] synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001638 [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell def: "An endothelial progenitor cell that participates in angiogenesis during development." [] is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0002548 name: fibroblast of cardiac tissue def: "A fibroblast that is part of the heart." [] synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000948 [Term] id: CL:0002553 name: fibroblast of lung def: "A fibroblast that is part of lung." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:0002554 name: fibroblast of lymphatic vessel def: "A fibroblast of the lymphatic system." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001473 [Term] id: CL:0002555 name: fibroblast of mammary gland def: "A fibroblast that is part of the mammary gland." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001911 [Term] id: CL:0002557 name: fibroblast of pulmonary artery def: "A fibroblast of pulmonary artery." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002012 [Term] id: CL:0002559 name: hair follicle cell def: "An animal cell that is part of a hair follicle." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002073 [Term] id: CL:0002563 name: intestinal epithelial cell def: "An epithelial cell of the intestine." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000160 relationship: BFO:0000050 UBERON:0001277 [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [] synonym: "mesenchymal stem cell of adipose" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001013 [Term] id: CL:0002571 name: hepatic mesenchymal stem cell def: "A mesenchymal stem cell of liver." [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002195 ! hepatic stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002107 [Term] id: CL:0002573 name: Schwann cell def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." [] is_a: CL:0000125 ! glial cell relationship: BFO:0000050 UBERON:0000010 [Term] id: CL:0002574 name: stromal cell of pancreas def: "A stromal cell of the pancreas." [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0001264 [Term] id: CL:0002575 name: central nervous system pericyte def: "A pericyte of the central nervous system." [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0001017 [Term] id: CL:0002577 name: placental epithelial cell def: "An epithelial cell of the placenta." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:0002584 name: renal cortical epithelial cell def: "An epithelial cell of the kidney cortex." [] is_a: CL:0002518 ! kidney epithelial cell is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: BFO:0000050 UBERON:0001225 [Term] id: CL:0002585 name: retinal blood vessel endothelial cell def: "A blood vessel endothelial cell that is part of the retina." [] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000966 [Term] id: CL:0002586 name: retinal pigment epithelial cell def: "An epithelial cell of the retinal pigmented epithelium." [] is_a: CL:0000066 ! epithelial cell is_a: CL:0000149 ! visual pigment cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001782 relationship: BFO:0000051 GO:0042470 [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature def: "A vascular associated smooth muscle cell of the brain vasculature." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0000955 [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery def: "A smooth muscle of the pulmonary artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002012 [Term] id: CL:0002592 name: smooth muscle cell of the coronary artery def: "A smooth muscle cell of the coronary artery." [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001621 [Term] id: CL:0002597 name: smooth muscle cell of bladder def: "A smooth muscle cell of the bladder." [] is_a: CL:0000192 ! smooth muscle cell is_a: CL:1001319 ! bladder cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001255 [Term] id: CL:0002598 name: bronchial smooth muscle cell is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002185 [Term] id: CL:0002599 name: smooth muscle cell of the esophagus def: "A smooth muscle cell of the esophagus." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001043 [Term] id: CL:0002601 name: uterine smooth muscle cell def: "A smooth muscle cell of the uterus." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0000995 [Term] id: CL:0002603 name: astrocyte of the cerebellum def: "An astrocyte of the cerebellum." [] is_a: CL:0000127 ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002037 [Term] id: CL:0002604 name: hippocampal astrocyte def: "An astrocyte that is part of the hippocampus." [] synonym: "astrocyte of the hippocampal formation" EXACT [] synonym: "astrocyte of the hippocampus" EXACT [] is_a: CL:0000127 ! astrocyte is_a: CL:1001580 ! hippocampal glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002421 [Term] id: CL:0002605 name: astrocyte of the cerebral cortex def: "An astrocyte of the cerebral cortex." [] is_a: CL:0000127 ! astrocyte is_a: CL:1001579 ! cerebral cortex glial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0000956 [Term] id: CL:0002606 name: astrocyte of the spinal cord def: "An astrocyte of the spinal cord." [] is_a: CL:0000127 ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002240 [Term] id: CL:0002607 name: migratory enteric neural crest cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0002608 name: hippocampal neuron def: "A neuron with a soma found in the hippocampus." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002421 [Term] id: CL:0002611 name: neuron of the dorsal spinal cord def: "A CNS neuron of the dorsal spinal cord." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0002100 UBERON:0002256 [Term] id: CL:0002612 name: neuron of the ventral spinal cord def: "A neuron of the ventral spinal cord." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0002100 UBERON:0002257 [Term] id: CL:0002613 name: striatum neuron def: "A neuron of the striatum." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0002100 UBERON:0002435 [Term] id: CL:0002614 name: neuron of the substantia nigra def: "A neuron of the substantia nigra." [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0002100 UBERON:0002038 [Term] id: CL:0002620 name: skin fibroblast def: "A fibroblast of skin." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002097 [Term] id: CL:0002622 name: prostate stromal cell def: "A stromal cell of the prostate." [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002367 [Term] id: CL:0002623 name: acinar cell of salivary gland def: "An acinar cell of salivary gland." [] is_a: CL:0000622 ! acinar cell is_a: CL:1001596 ! salivary gland glandular cell intersection_of: CL:0000622 ! acinar cell intersection_of: BFO:0000050 UBERON:0001044 [Term] id: CL:0002625 name: seminiferous tubule epithelial cell def: "A cell of the seminiferous tubule epithelium." [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001343 relationship: BFO:0000050 UBERON:0004813 [Term] id: CL:0002629 name: mature microglial cell def: "A mature microglial cell that has changed shape to an amoeboid morphology and is capable of cytokine production and antigen presentation." [] synonym: "activated microglia" EXACT [] synonym: "mature microglia" EXACT [] synonym: "reactive microglia" EXACT [] is_a: CL:0000129 ! microglial cell intersection_of: CL:0000129 ! microglial cell intersection_of: RO:0002215 GO:0001816 intersection_of: RO:0002215 GO:0002536 intersection_of: RO:0002215 GO:0002537 intersection_of: RO:0002215 GO:0006909 intersection_of: RO:0002215 GO:0019882 [Term] id: CL:0002630 name: actinomycete-type spore def: "A spore formed from bacteria in the order Actinomycetales." [] is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0002368 ! respiratory epithelial cell intersection_of: BFO:0000050 UBERON:0001558 [Term] id: CL:0002633 name: respiratory basal cell def: "A basal cell in the respiratory tract." [] synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] is_a: CL:0000646 ! basal cell is_a: CL:0002368 ! respiratory epithelial cell [Term] id: CL:0002639 name: amniotic stem cell def: "An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone" [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002323 ! amniocyte [Term] id: CL:0002657 name: glandular cell of esophagus def: "A glandular epithelial cell of the esophagus." [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001043 [Term] id: CL:0002658 name: glandular cell of the large intestine def: "A glandular epithelial cell of the large intestine." [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000059 [Term] id: CL:0002659 name: glandular cell of stomach def: "A glandular epithelial cell that is part of the stomach." [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000945 [Term] id: CL:0002664 name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [] synonym: "cardiovascular progenitor cell" EXACT [] synonym: "CPC" RELATED [] is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0002671 name: endothelial stalk cell def: "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." [] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0002672 name: retinal progenitor cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [] is_a: CL:0000048 ! multi fate stem cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0002673 name: tongue muscle cell def: "A skeletal muscle cell that is part of the tongue." [] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: BFO:0000050 UBERON:0000378 [Term] id: CL:0002676 name: neural crest derived neuroblast def: "A neuroblast derived from a neural crest cell." [] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0002678 name: memory regulatory T cell def: "A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen." [] is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell is_a: CL:0000813 ! memory T cell is_a: CL:0000815 ! regulatory T cell is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: RO:0002353 GO:0043379 [Term] id: CL:0002679 name: natural helper lymphocyte def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: lacks_plasma_membrane_part GO:0042105 intersection_of: lacks_plasma_membrane_part PR:000001002 intersection_of: lacks_plasma_membrane_part PR:000001012 intersection_of: lacks_plasma_membrane_part PR:000001013 intersection_of: lacks_plasma_membrane_part PR:000001020 intersection_of: lacks_plasma_membrane_part PR:000001084 intersection_of: lacks_plasma_membrane_part PR:000001874 intersection_of: lacks_plasma_membrane_part PR:000002981 intersection_of: RO:0002104 PR:000002065 intersection_of: RO:0002104 PR:000002979 [Term] id: CL:0002680 name: PP cell of intestine def: "A PP cell found in intestine." [] is_a: CL:0000696 ! PP cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000696 ! PP cell intersection_of: BFO:0000050 UBERON:0000160 [Term] id: CL:0002681 name: kidney cortical cell def: "A cell that is part of a cortex of kidney." [] is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001225 [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [] is_a: CL:0000402 ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 [Term] id: CL:0005001 name: iridoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0005002 name: xanthoblast def: "A non-terminally differentiated cell that differentiates into a xanthophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0005003 name: leucoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0005004 name: pigment erythroblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0005005 name: cyanoblast def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0005006 name: ionocyte def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [] is_a: CL:0000066 ! epithelial cell [Term] id: CL:0005012 name: multi-ciliated epithelial cell def: "A ciliated epithelial cell with many cilia." [] synonym: "MCC" RELATED [] synonym: "multi-ciliated cell" BROAD [] synonym: "multiciliated cell" BROAD [] synonym: "multiciliated epithelial cell" EXACT [] is_a: CL:0000067 ! ciliated epithelial cell relationship: BFO:0000051 GO:0005929 [Term] id: CL:0005018 name: ghrelin secreting cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036321 [Term] id: CL:0005019 name: pancreatic epsilon cell def: "Ghrelin secreting cells found in the endocrine pancreas." [] synonym: "pancreatic E cell" EXACT [] is_a: CL:0005018 ! ghrelin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell intersection_of: CL:0008024 ! pancreatic endocrine cell intersection_of: RO:0002215 GO:0036321 [Term] id: CL:0005020 name: lymphangioblast def: "Lymphatic progenitor cells." [] is_a: CL:0000048 ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: RO:0002220 UBERON:0004536 [Term] id: CL:0005022 name: vascular lymphangioblast def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [] synonym: "parachordal lymphangioblast" NARROW [] is_a: CL:0005020 ! lymphangioblast intersection_of: CL:0005020 ! lymphangioblast intersection_of: RO:0002220 UBERON:0001638 [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [] synonym: "somatic motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron is_a: CL:0000108 ! cholinergic neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002120 CL:0008002 ! skeletal muscle fiber relationship: RO:0002215 GO:0014055 [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [] is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0007000 name: preameloblast def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [] is_a: CL:0000055 ! non-terminally differentiated cell relationship: BFO:0000050 UBERON:0005176 relationship: RO:0002202 CL:0002077 ! ecto-epithelial cell relationship: RO:0002220 UBERON:0001763 [Term] id: CL:0007003 name: preodontoblast def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0005176 relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0007004 name: premigratory neural crest cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [] is_a: CL:0011012 ! neural crest cell relationship: BFO:0000050 UBERON:0002342 relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0007005 name: notochordal cell def: "Cell that is part of the notochord." [] is_a: CL:0000000 ! cell relationship: BFO:0000050 UBERON:0002328 relationship: RO:0002202 CL:0007006 ! chordamesodermal cell [Term] id: CL:0007006 name: chordamesodermal cell def: "Mesodermal cell that is axially located and gives rise to the cells of the notochord." [] synonym: "axial mesodermal cell" EXACT [] is_a: CL:0000222 ! mesodermal cell relationship: BFO:0000050 UBERON:0004880 [Term] id: CL:0007009 name: prechondroblast def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [] is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0007010 name: preosteoblast def: "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." [] synonym: "osteoprogenitor cell" EXACT [] is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0008883 relationship: RO:0002202 CL:0000222 ! mesodermal cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0007011 name: enteric neuron def: "Neuron that is part of the enteric nervous system." [] is_a: CL:0000029 ! neural crest derived neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002005 relationship: BFO:0000050 UBERON:0002005 relationship: RO:0002202 CL:0002607 ! migratory enteric neural crest cell [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [] is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0001134 intersection_of: BFO:0000051 GO:0030017 intersection_of: RO:0000053 PATO:0001908 intersection_of: RO:0000053 PATO:0002478 relationship: RO:0002202 CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0008003 name: somatic muscle myotube def: "A myotube that is part of some somatic muscle. Examples include arthropod somatic muscle cells." [] is_a: CL:0002372 ! myotube is_a: CL:0008004 ! somatic muscle cell intersection_of: CL:0008004 ! somatic muscle cell intersection_of: BFO:0000051 GO:0030017 intersection_of: RO:0000053 PATO:0001908 intersection_of: RO:0000053 PATO:0002478 [Term] id: CL:0008004 name: somatic muscle cell def: "A muscle cell that is part of some somatic muscle." [] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle." [] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:8600004 [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0001410 {all_some="true"} [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [] is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} [Term] id: CL:0008011 name: skeletal muscle satellite stem cell def: "A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast." [] is_a: CL:0000035 ! single fate stem cell is_a: CL:0000594 ! skeletal muscle satellite cell intersection_of: CL:0000594 ! skeletal muscle satellite cell intersection_of: RO:0000053 PATO:0001400 intersection_of: RO:0002215 GO:0017145 [Term] id: CL:0008012 name: quiescent skeletal muscle satellite cell def: "A skeletal muscle satellite cell that is mitotically quiescent. These cells are wedge shaped and have a large nuclear to cytoplasmic ratio with few organelles, a small nucleus and condensed interphase chromatin. Satellite cells typically remain in this state until activated following muscle damage." [] is_a: CL:0000594 ! skeletal muscle satellite cell [Term] id: CL:0008016 name: activated skeletal muscle satellite cell def: "A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage." [] is_a: CL:0000594 ! skeletal muscle satellite cell relationship: RO:0002202 CL:0008012 ! quiescent skeletal muscle satellite cell [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [] synonym: "myogenic precursor cell" BROAD [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001134 intersection_of: RO:0002203 CL:0008002 ! skeletal muscle fiber [Term] id: CL:0008018 name: somatic muscle myoblast def: "A myoblast that is commited to developing into a somatic muscle." [] is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008003 ! somatic muscle myotube [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] synonym: "mesenchyme cell" EXACT [] is_a: CL:0000000 ! cell relationship: BFO:0000050 UBERON:0003104 relationship: RO:0002215 GO:0016477 [Term] id: CL:0008021 name: anterior lateral line ganglion neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:2001391 [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [] is_a: CL:0000569 ! cardiac mesenchymal cell intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: BFO:0000050 UBERON:0002062 [Term] id: CL:0008024 name: pancreatic endocrine cell def: "An endocrine cell that is part of the pancreas." [] is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 ! enteroendocrine cell intersection_of: CL:0000163 ! endocrine cell intersection_of: BFO:0000050 UBERON:0001264 [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061533 [Term] id: CL:0008026 name: open tracheal system tracheocyte def: "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003127 [Term] id: CL:0008028 name: visual system neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002216 GO:0007601 [Term] id: CL:0008031 name: cortical interneuron def: "An interneuron that has its soma located in the cerebral cortex." [] synonym: "cerebral cortex interneuron" EXACT [] is_a: CL:0000099 ! interneuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000956 [Term] id: CL:0008033 name: decidual pericyte def: "A pericyte of the decidual vasculature." [] synonym: "decidual perivascular cell" EXACT [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002450 [Term] id: CL:0008034 name: mural cell def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [] is_a: CL:4033054 ! perivascular cell [Term] id: CL:0008038 name: alpha motor neuron def: "A large, multipolar lower motor neuron of the brainstem and spinal cord that innervates the extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. While their cell bodies are in the CNS (in the anterior gray horn of the spinal cord), they are part of the somatic nervous system - a branch of the PNS." [] synonym: "alpha motoneuron" EXACT [] is_a: CL:0008039 ! lower motor neuron relationship: RO:0002120 CL:0008046 ! extrafusal muscle fiber [Term] id: CL:0008039 name: lower motor neuron def: "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." [] is_a: CL:0005024 ! somatomotor neuron relationship: RO:0002120 CL:0008002 ! skeletal muscle fiber relationship: RO:0002162 NCBITaxon:7742 [Term] id: CL:0008046 name: extrafusal muscle fiber def: "A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons." [] synonym: "myofibra extrafusalis" EXACT [] is_a: CL:0008002 ! skeletal muscle fiber relationship: RO:0002103 CL:0008038 ! alpha motor neuron [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] is_a: CL:0000000 ! cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [] is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: BFO:0000050 UBERON:0005388 [Term] id: CL:0009006 name: enteroendocrine cell of small intestine def: "An enteroendocrine cell that is located in the small intestine." [] synonym: "small intestine enteroendocrine cell" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0002108 [Term] id: CL:0009014 name: Peyer's patch lymphocyte def: "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." [] synonym: "Peyer's patch resident lymphocyte" EXACT [] synonym: "small intestine Peyer's patch lymphocyte" NARROW [] is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0001211 [Term] id: CL:0009015 name: Peyer's patch follicular dendritic cell def: "A follicular dendritic cell located in the Peyer's patch. These cells from a meshwork in which Peyer's patch B cells reside." [] is_a: CL:0000442 ! follicular dendritic cell intersection_of: CL:0000442 ! follicular dendritic cell intersection_of: BFO:0000050 UBERON:0001211 [Term] id: CL:0009024 name: mesothelial cell of small intestine def: "A mesothelial cell that is part of the small intestine." [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002108 [Term] id: CL:0009025 name: mesothelial cell of colon def: "A mesothelial cell that is part of the colon." [] synonym: "mesothelial cell of large intestine" BROAD [] is_a: CL:0000077 ! mesothelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:0009038 name: colon macrophage def: "A macrophage that is located in the colon." [] synonym: "macrophage of colon" EXACT [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:0009039 name: colon goblet cell def: "A goblet cell that is located in the colon." [] synonym: "goblet cell of colon" EXACT [] is_a: CL:0000160 ! goblet cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:0009042 name: enteroendocrine cell of colon def: "An enteroendocrine cell that is located in the colon." [] synonym: "colon enteroendocrine cell" EXACT [] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:1001588 ! colon glandular cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:0009084 name: epithelial cell of endometrial gland def: "An epithelial cell that is part of an endometrial gland." [] synonym: "endometrial glandular epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002451 [Term] id: CL:0009089 name: lung pericyte def: "A pericyte cell that is part of a lung." [] synonym: "lung pericyte cell" EXACT [] synonym: "pulmonary pericyte" EXACT [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:0009091 name: Leydig stem cell def: "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." [] synonym: "stem Leydig cell" EXACT [] is_a: CL:0000034 ! stem cell relationship: BFO:0000050 UBERON:0005212 [Term] id: CL:0009092 name: endothelial cell of placenta def: "An endothelial cell that is part of a placenta." [] synonym: "placental endothelial cell" EXACT [] is_a: CL:0000115 ! endothelial cell is_a: CL:0002577 ! placental epithelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:0009093 name: smooth muscle cell of placenta def: "A smooth muscle cell that is part of a placenta." [] synonym: "placental smooth muscle cell" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:0009095 name: endothelial cell of uterus def: "An endothelial cell that is part of a uterus." [] synonym: "uterine endothelial cell" EXACT [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000995 [Term] id: CL:0009115 name: lymph node lymphatic vessel endothelial cell def: "An endothelial cell located in a lymph node lymphatic vessel." [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000029 intersection_of: BFO:0000050 UBERON:0001473 [Term] id: CL:0009116 name: progenitor cell of mammary luminal epithelium def: "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells." [] synonym: "luminal progenitor cell" BROAD [] synonym: "progenitor cell of luminal mammary epithelium" EXACT [] is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 UBERON:0001911 [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002371 [Term] id: CL:0010003 name: epithelial cell of alveolus of lung def: "An epithelial cell that is part_of a alveolus of lung." [] synonym: "alveolus of lung epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002299 [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "A mononuclear cell that is part_of a bone marrow." [] synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear cell is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: BFO:0000050 UBERON:0002371 [Term] id: CL:0010005 name: atrioventricular bundle cell def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [] synonym: "AV bundle cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002353 [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000948 [Term] id: CL:0010007 name: His-Purkinje system cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0004146 [Term] id: CL:0010008 name: cardiac endothelial cell is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000948 [Term] id: CL:0010009 name: camera-type eye photoreceptor cell synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000019 [Term] id: CL:0010010 name: cerebellar stellate cell is_a: CL:0000122 ! stellate neuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000122 ! stellate neuron intersection_of: RO:0002100 UBERON:0002037 [Term] id: CL:0010011 name: cerebral cortex GABAergic interneuron def: "A GABAergic interneuron whose soma is located in the cerebral cortex." [] is_a: CL:0008031 ! cortical interneuron is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: RO:0002100 UBERON:0000956 [Term] id: CL:0010012 name: cerebral cortex neuron def: "A CNS neuron of the cerebral cortex." [] synonym: "cortical neuron" EXACT [] synonym: "neuron of cerebral cortex" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000956 [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] is_a: CL:0000000 ! cell [Term] id: CL:0010020 name: cardiac glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0000948 [Term] id: CL:0010021 name: cardiac myoblast is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron def: "A neuron that has its soma in the heart." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000948 [Term] id: CL:0011000 name: dorsal horn interneuron def: "A CNS interneuron located in the dorsal horn of the spinal cord." [] synonym: "dorsal spinal cord interneuron" RELATED [] is_a: CL:0005000 ! spinal cord interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002256 [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [] is_a: CL:0000100 ! motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002240 [Term] id: CL:0011002 name: lateral motor column neuron def: "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [] is_a: CL:0011001 ! spinal cord motor neuron [Term] id: CL:0011004 name: lens fiber cell def: "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [] synonym: "lens fibre cell" EXACT [] is_a: CL:0002222 ! vertebrate lens cell [Term] id: CL:0011005 name: GABAergic interneuron def: "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" [] synonym: "GABAergic inhibitory interneuron" EXACT [] is_a: CL:0000498 ! inhibitory interneuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002215 GO:0061534 [Term] id: CL:0011006 name: Lugaro cell def: "An inhibitory GABAergic interneuron found in the cerebellar cortex." [] is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron relationship: RO:0002100 UBERON:0002129 [Term] id: CL:0011008 name: embryonic hemocyte def: "A hemocyte derived from the embryonic head mesoderm, which enters the hemolymph as a circulating cell." [] is_a: CL:0000387 ! hemocyte (sensu Arthropoda) [Term] id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0011013 name: motile sperm cell def: "A sperm cell that is cabaple of motion (motility)." [] is_a: CL:0000019 ! sperm intersection_of: CL:0000019 ! sperm intersection_of: RO:0002215 GO:0097722 [Term] id: CL:0011014 name: non-motile sperm cell def: "A sperm cell that is not cabaple of motion (motility)." [] is_a: CL:0000019 ! sperm [Term] id: CL:0011015 name: amoeboid sperm cell def: "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." [] is_a: CL:0011013 ! motile sperm cell [Term] id: CL:0011016 name: flagellated sperm cell def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." [] is_a: CL:0011013 ! motile sperm cell intersection_of: CL:0011013 ! motile sperm cell intersection_of: RO:0002215 GO:0030317 [Term] id: CL:0011019 name: mesothelial cell of epicardium def: "A mesothelial cell that is part of the epicardium." [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002348 [Term] id: CL:0011020 name: neural progenitor cell def: "An undifferentiated cell that originates from a neural stem cell and has the capacity to generate multiple types of lineage-restricted progenitors but not to self-renew." [] is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0011024 name: double negative T regulatory cell def: "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." [] synonym: "CD4-negative, CD8-negative, alpha-beta regulatory T cells" EXACT [] synonym: "DN Treg" EXACT [] synonym: "double-negative alpha-beta regulatory T cell" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0002489 ! double negative thymocyte intersection_of: RO:0002215 GO:0050777 [Term] id: CL:0011025 name: exhausted T cell synonym: "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential." EXACT [] synonym: "Tex cell" EXACT [] is_a: CL:0000911 ! effector T cell [Term] id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [] is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002202 CL:0000034 ! stem cell [Term] id: CL:0011027 name: skeletal muscle fibroblast def: "Any fibroblast that is part of skeletal muscle tissue." [] synonym: "skeleton muscle fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001134 [Term] id: CL:0011101 name: chorionic trophoblast cell def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [] is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: BFO:0000050 UBERON:0003124 [Term] id: CL:0011103 name: sympathetic neuron def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [] is_a: CL:0000107 ! autonomic neuron [Term] id: CL:0011108 name: colon epithelial cell def: "Epithelial cell that is part of the colon epithelium." [] synonym: "colonic epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001155 relationship: BFO:0000050 UBERON:0000397 [Term] id: CL:0011109 name: hypocretin-secreting neuron def: "A neuron that releases hypocretin as a neurotransmitter." [] synonym: "orexin" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061585 [Term] id: CL:0011110 name: histaminergic neuron def: "Neuron that secretes histamine." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061538 [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0030154 [Term] id: CL:0012000 name: astrocyte of the forebrain def: "An astrocyte of the forebrain." [] synonym: "forebrain astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0001890 [Term] id: CL:0012001 name: neuron of the forebrain def: "A CNS neuron of the forebrain." [] synonym: "forebrain neuron" EXACT [] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: RO:0002100 UBERON:0001890 [Term] id: CL:0013000 name: forebrain radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0001890 [Term] id: CL:0017002 name: prostate neuroendocrine cell def: "A neuroendocrine cell that is part of the prostate epithelium." [] synonym: "neuroendocrine cell of prostate epithelium" EXACT [] synonym: "neuroendocrine cell of the prostate" EXACT [] is_a: CL:0000165 ! neuroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0000428 [Term] id: CL:0017500 name: neutrophillic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [] is_a: GO:0005737 intersection_of: GO:0005737 intersection_of: RO:0000053 PATO:0070046 [Term] id: CL:0017502 name: acidophilic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 intersection_of: GO:0005737 intersection_of: RO:0000053 PATO:0002418 [Term] id: CL:0017503 name: basophilic cytoplasm def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [] is_a: GO:0005737 intersection_of: GO:0005737 intersection_of: RO:0000053 PATO:0002094 [Term] id: CL:0017504 name: polychromatophilic cytoplasm def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [] is_a: GO:0005737 intersection_of: GO:0005737 intersection_of: RO:0000053 PATO:0070047 [Term] id: CL:0017506 name: banded nucleus def: "A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament." [] is_a: GO:0005634 [Term] id: CL:0017507 name: reniform nucleus def: "A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin." [] is_a: GO:0005634 intersection_of: GO:0005634 intersection_of: RO:0000053 PATO:0001871 [Term] id: CL:0017508 name: cartwheel heterochromatin def: "Heterochromatin that is arranged in a carthwheel pattern." [] is_a: GO:0000792 [Term] id: CL:0017509 name: alobate nucleus is_a: GO:0005634 intersection_of: GO:0005634 intersection_of: RO:0000053 PATO:0002506 [Term] id: CL:0019002 name: tracheobronchial chondrocyte def: "Any chondrocyte that is part of the tracheobronchial tree." [] synonym: "chondrocyte of tracheobronchial tree" EXACT [] is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0007196 [Term] id: CL:0019003 name: tracheobronchial goblet cell def: "Any goblet cell that is part of the tracheobronchial epithelium." [] synonym: "goblet cell of tracheobronchial tree" EXACT [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002370 ! respiratory goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0007196 [Term] id: CL:0019017 name: lymphatic vessel smooth muscle cell def: "A smooth muscle cell that is part of any lymphatic vessel." [] synonym: "smooth muscle cell of lymphatic vessel" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001473 [Term] id: CL:0019018 name: blood vessel smooth muscle cell def: "A smooth muscle cell that is part of any blood vessel." [] synonym: "smooth muscle cell of blood vessel" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001981 [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell def: "A smooth muscle cell that is part of the tracheobronchial tree." [] synonym: "smooth muscle cell of tracheobronchial tree" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0007196 [Term] id: CL:0019031 name: intestine goblet cell def: "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." [] synonym: "intestinal goblet cell" EXACT [] is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001277 [Term] id: CL:1000001 name: retrotrapezoid nucleus neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0009918 [Term] id: CL:1000022 name: mesonephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005329 [Term] id: CL:1000042 name: forebrain neuroblast is_a: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: BFO:0000050 UBERON:0001890 [Term] id: CL:1000050 name: lateral line nerve glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0008906 [Term] id: CL:1000073 name: spinal cord radial glial cell is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0002240 [Term] id: CL:1000090 name: pronephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005310 [Term] id: CL:1000123 name: metanephric nephron tubule epithelial cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005146 [Term] id: CL:1000143 name: lung goblet cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0000160 ! goblet cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:1000147 name: cardiac valve cell def: "A cell that is part of a cardiac valve." [] synonym: "heart valve cell" EXACT [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000946 [Term] id: CL:1000155 name: Malpighian tubule stellate cell def: "A specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [] synonym: "Malpighian tubule Type II cell" EXACT [] is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0001054 [Term] id: CL:1000182 name: malpighian tubule tip cell is_a: CL:0000423 ! tip cell intersection_of: CL:0000423 ! tip cell intersection_of: BFO:0000050 UBERON:0001054 [Term] id: CL:1000217 name: growth plate cartilage chondrocyte is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0004129 [Term] id: CL:1000222 name: stomach neuroendocrine cell is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 [Term] id: CL:1000223 name: lung neuroendocrine cell def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [] synonym: "PNEC" RELATED [] synonym: "pulmonary neuroendocrine cell" EXACT [] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002048 relationship: BFO:0000051 GO:0031045 relationship: RO:0002215 GO:0001820 relationship: RO:0002215 GO:0070483 [Term] id: CL:1000236 name: posterior lateral line nerve glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:2000175 [Term] id: CL:1000239 name: anterior lateral line nerve glial cell is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:2000425 [Term] id: CL:1000245 name: posterior lateral line ganglion neuron is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:2001314 [Term] id: CL:1000271 name: lung ciliated cell is_a: CL:4030034 ! respiratory ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:1000272 name: lung secretory cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:1000274 name: trophectodermal cell synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:1000275 name: smooth muscle cell of small intestine def: "A smooth muscle cell that is part of the small intestine." [] synonym: "non-striated muscle fiber of small intestine" EXACT [] is_a: CL:0002504 ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0002108 [Term] id: CL:1000279 name: smooth muscle cell of large intestine def: "A smooth muscle cell that is part of the large intestine." [] synonym: "non-striated muscle fiber of large intestine" EXACT [] is_a: CL:0002504 ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0000059 [Term] id: CL:1000280 name: smooth muscle cell of colon def: "A smooth muscle cell that is part of the colon." [] synonym: "non-striated muscle fiber of colon" EXACT [] is_a: CL:0002504 ! enteric smooth muscle cell intersection_of: CL:0002504 ! enteric smooth muscle cell intersection_of: BFO:0000050 UBERON:0001155 [Term] id: CL:1000281 name: smooth muscle cell of cecum def: "A smooth muscle cell that is part of the cecum." [] synonym: "non-striated muscle fiber of cecum" EXACT [] synonym: "smooth muscle fiber of cecum" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001153 [Term] id: CL:1000296 name: epithelial cell of urethra def: "An epithelial cell that is part of the urethra." [] is_a: CL:0000066 ! epithelial cell is_a: CL:1001320 ! urethra cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000057 [Term] id: CL:1000312 name: bronchial goblet cell def: "A goblet cell that is part of the epithelium of bronchus." [] synonym: "goblet cell of epithelium of bronchus" EXACT [] is_a: CL:0000160 ! goblet cell is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002185 relationship: BFO:0000050 UBERON:0002031 [Term] id: CL:1000313 name: gastric goblet cell def: "A goblet cell that is part of the epithelium of stomach." [] synonym: "goblet cell of epithelium of stomach" EXACT [] is_a: CL:0000160 ! goblet cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000945 relationship: BFO:0000050 UBERON:0001276 [Term] id: CL:1000320 name: large intestine goblet cell def: "A goblet cell that is part of the epithelium of large intestine." [] synonym: "goblet cell of epithelium of large intestine" EXACT [] is_a: CL:0000160 ! goblet cell is_a: CL:0002658 ! glandular cell of the large intestine intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0000059 relationship: BFO:0000050 UBERON:0001278 [Term] id: CL:1000322 name: pancreatic goblet cell def: "A goblet cell that is part of the epithelium of pancreatic duct." [] synonym: "goblet cell of epithelium of pancreatic duct" EXACT [] is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0001264 relationship: BFO:0000050 UBERON:0009970 [Term] id: CL:1000334 name: enterocyte of epithelium of small intestine def: "An enterocyte that is part of the epithelium of small intestine." [] is_a: CL:0000584 ! enterocyte intersection_of: CL:0000584 ! enterocyte intersection_of: BFO:0000050 UBERON:0001902 [Term] id: CL:1000347 name: enterocyte of colon def: "A columnar cell of the colon that is part of the colonic epithelium." [] synonym: "vacuolar absorptive cell of epithelium of colon" NARROW [] is_a: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine intersection_of: BFO:0000050 UBERON:0000397 [Term] id: CL:1000349 name: basal cell of epithelium of bronchus def: "A basal cell found in the bronchus epithelium." [] synonym: "basal cell of bronchus" EXACT [] is_a: CL:0002329 ! basal epithelial cell of tracheobronchial tree is_a: CL:0002633 ! respiratory basal cell intersection_of: CL:0002633 ! respiratory basal cell intersection_of: BFO:0000050 UBERON:0002031 [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum def: "A Purkinje myocyte that is part of the interventricular septum." [] is_a: CL:0002068 ! Purkinje myocyte intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002094 [Term] id: CL:1000391 name: melanocyte of eyelid def: "A melanocyte that is part of the eyelid." [] synonym: "eyelid melanocyte" EXACT [] synonym: "sebaceous gland of wolff" EXACT [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0001711 [Term] id: CL:1000409 name: myocyte of sinoatrial node def: "A muscle cell that is part of the sinoatrial node." [] synonym: "SA nodal myocyte" EXACT [] synonym: "SA node cardiac muscle cell" EXACT [] synonym: "sinoatrial node cell" EXACT [] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [] is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002351 [Term] id: CL:1000410 name: myocyte of atrioventricular node def: "A muscle cell that is part of the atrioventricular node." [] synonym: "atrioventricular node cell" EXACT [] synonym: "atrioventricular node myocyte" EXACT [] synonym: "AV nodal myocyte" EXACT [] synonym: "AV node cardiac muscle cell" EXACT [] synonym: "AV node cell" EXACT [] is_a: CL:0002072 ! nodal myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002352 [Term] id: CL:1000413 name: endothelial cell of artery def: "A blood vessel endothelial cell that is part of an arterial endothelium." [] synonym: "arterial endothelial cell" EXACT [] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001637 relationship: BFO:0000050 UBERON:0001917 [Term] id: CL:1000415 name: epithelial cell of gallbladder def: "An epithelial cell that is part of the gallbladder." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002110 [Term] id: CL:1000426 name: chromaffin cell of adrenal gland def: "A chromaffin cell that is part of the adrenal gland." [] synonym: "adrenal chromaffin cell" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002369 [Term] id: CL:1000427 name: adrenal cortex chromaffin cell def: "A chromaffin cell that is part of the adrenal cortex." [] synonym: "chromaffin cell of adrenal cortex" EXACT [] is_a: CL:0000166 ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0001235 [Term] id: CL:1000428 name: stem cell of epidermis def: "A somatic stem cell that is part of the epidermis." [] synonym: "epidermal stem cell" EXACT [] is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: BFO:0000050 UBERON:0001003 [Term] id: CL:1000443 name: ciliary muscle cell def: "A smooth muscle cell that is part of the ciliary body." [] synonym: "smooth muscle cell of ciliary body" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001775 [Term] id: CL:1000448 name: epithelial cell of sweat gland def: "An epithelial cell that is part of the sweat gland." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001820 [Term] id: CL:1000449 name: epithelial cell of nephron def: "An epithelial cell that is part of the nephron." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001285 [Term] id: CL:1000450 name: epithelial cell of glomerular capsule def: "An epithelial cell that is part of the glomerular capsule." [] synonym: "Bowmans capsule epithelial cell" EXACT [] synonym: "epithelial cell of Bowman's capsule" EXACT [] is_a: CL:1000510 ! kidney glomerular epithelial cell is_a: CL:1000612 ! kidney corpuscule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001230 [Term] id: CL:1000454 name: kidney collecting duct epithelial cell def: "An epithelial cell that is part of the collecting duct of renal tubule." [] synonym: "epithelial cell of renal collecting tubule" EXACT [] is_a: CL:0000072 ! non-branched duct epithelial cell is_a: CL:0002518 ! kidney epithelial cell is_a: CL:1001225 ! kidney collecting duct cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001232 [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum def: "A mesothelial cell that is part of the parietal peritoneum." [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001366 [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum def: "A mesothelial cell that is part of the visceral peritoneum." [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001178 [Term] id: CL:1000458 name: melanocyte of skin def: "A melanocyte that is part of the skin of body." [] synonym: "skin melanocyte" EXACT [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0002097 [Term] id: CL:1000465 name: chromaffin cell of ovary def: "A chromaffin cell that is part of the ovary." [] is_a: CL:0000166 ! chromaffin cell is_a: CL:2000064 ! ovarian surface epithelial cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0000992 [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node def: "A Purkinje myocyte that is part of the atrioventricular node." [] is_a: CL:0002068 ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002352 [Term] id: CL:1000484 name: Purkinje myocyte of atrioventricular bundle def: "A Purkinje myocyte that is part of the atrioventricular bundle." [] is_a: CL:0002068 ! Purkinje myocyte is_a: CL:0010005 ! atrioventricular bundle cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002353 [Term] id: CL:1000486 name: basal cell of urothelium def: "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." [] synonym: "urothelial basal cell" EXACT [] is_a: CL:0000646 ! basal cell is_a: CL:0000731 ! urothelial cell intersection_of: CL:0000646 ! basal cell intersection_of: BFO:0000050 UBERON:0000365 [Term] id: CL:1000487 name: smooth muscle cell of prostate def: "A smooth muscle cell that is part of the prostate gland." [] synonym: "smooth muscle fiber of prostate" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002367 [Term] id: CL:1000488 name: cholangiocyte def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [] synonym: "epithelial cell of bile duct" EXACT [] is_a: CL:0000069 ! branched duct epithelial cell intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: BFO:0000050 UBERON:0002394 intersection_of: RO:0002215 GO:0015106 relationship: RO:0002202 CL:0005026 ! hepatoblast [Term] id: CL:1000490 name: mesothelial cell of peritoneum def: "A mesothelial cell that is part of the peritoneum." [] synonym: "peritoneal mesothelial cell" EXACT [] is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002358 [Term] id: CL:1000494 name: nephron tubule epithelial cell def: "An epithelial cell that is part of a nephron tubule." [] synonym: "kidney tubule epithelial cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004810 [Term] id: CL:1000495 name: small intestine goblet cell def: "A goblet cell that is part of the small intestine." [] synonym: "goblet cell of epithelium of small intestine" EXACT [] synonym: "goblet cell of small intestine" EXACT [] synonym: "small intestinal goblet cell" EXACT [] is_a: CL:0000160 ! goblet cell is_a: CL:1001598 ! small intestine glandular cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002108 relationship: BFO:0000050 UBERON:0001902 [Term] id: CL:1000497 name: kidney cell def: "A cell that is part of a kidney." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002113 [Term] id: CL:1000500 name: kidney interstitial cell def: "A cell that is part of kidney interstitium." [] is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0005215 [Term] id: CL:1000504 name: kidney medulla cell def: "A cell that is part of a renal medulla." [] is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0000362 [Term] id: CL:1000507 name: kidney tubule cell def: "A cell that is part of a nephron tubule." [] is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001231 [Term] id: CL:1000510 name: kidney glomerular epithelial cell is_a: CL:0002518 ! kidney epithelial cell intersection_of: CL:0002518 ! kidney epithelial cell intersection_of: BFO:0000050 UBERON:0004188 relationship: BFO:0000050 UBERON:0004188 [Term] id: CL:1000546 name: kidney medulla collecting duct epithelial cell def: "An epithelial cell that is part of a renal medulla collecting duct." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005185 [Term] id: CL:1000547 name: kidney inner medulla collecting duct epithelial cell def: "An epithelial cell that is part of some inner medullary collecting duct." [] is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004205 [Term] id: CL:1000548 name: kidney outer medulla collecting duct epithelial cell def: "An epithelial cell that is part of an outer medullary collecting duct." [] is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004204 [Term] id: CL:1000549 name: kidney cortex collecting duct epithelial cell def: "An epithelial cell that is part of a cortical collecting duct." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004203 [Term] id: CL:1000601 name: ureteral cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000056 relationship: BFO:0000050 UBERON:0000056 [Term] id: CL:1000606 name: kidney nerve cell is_a: CL:1000500 ! kidney interstitial cell is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002113 [Term] id: CL:1000612 name: kidney corpuscule cell is_a: CL:0002584 ! renal cortical epithelial cell intersection_of: CL:0002584 ! renal cortical epithelial cell intersection_of: BFO:0000050 UBERON:0001229 relationship: BFO:0000050 UBERON:0001229 [Term] id: CL:1000615 name: kidney cortex tubule cell is_a: CL:0002584 ! renal cortical epithelial cell is_a: CL:1000507 ! kidney tubule cell intersection_of: CL:1000507 ! kidney tubule cell intersection_of: BFO:0000050 UBERON:0006853 relationship: BFO:0000050 UBERON:0006853 [Term] id: CL:1000616 name: kidney outer medulla cell is_a: CL:1000504 ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: BFO:0000050 UBERON:0001293 relationship: BFO:0000050 UBERON:0001293 [Term] id: CL:1000617 name: kidney inner medulla cell is_a: CL:1000504 ! kidney medulla cell intersection_of: CL:1000504 ! kidney medulla cell intersection_of: BFO:0000050 UBERON:0001294 relationship: BFO:0000050 UBERON:0001294 [Term] id: CL:1000618 name: juxtaglomerular complex cell synonym: "juxtaglomerulus cell" EXACT [] is_a: CL:0002681 ! kidney cortical cell intersection_of: CL:0002681 ! kidney cortical cell intersection_of: BFO:0000050 UBERON:0002303 relationship: BFO:0000050 UBERON:0002303 [Term] id: CL:1000692 name: kidney interstitial fibroblast is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005215 [Term] id: CL:1000706 name: ureter urothelial cell is_a: CL:0000731 ! urothelial cell is_a: CL:1000601 ! ureteral cell intersection_of: CL:0000731 ! urothelial cell intersection_of: BFO:0000050 UBERON:0001254 relationship: BFO:0000050 UBERON:0001254 [Term] id: CL:1000742 name: glomerular mesangial cell def: "A mesangial cell located among the glomerular capillaries in a renal corpuscle." [] synonym: "intraglomerular mesangial cell" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000650 ! mesangial cell is_a: CL:1000612 ! kidney corpuscule cell relationship: BFO:0000050 UBERON:0002320 relationship: RO:0002215 GO:0006909 relationship: RO:0002215 GO:0070252 [Term] id: CL:1000746 name: glomerular cell is_a: CL:1000612 ! kidney corpuscule cell intersection_of: CL:1000612 ! kidney corpuscule cell intersection_of: BFO:0000050 UBERON:0000074 relationship: BFO:0000050 UBERON:0000074 [Term] id: CL:1000768 name: kidney connecting tubule epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: BFO:0000050 UBERON:0005097 relationship: BFO:0000050 UBERON:0005097 [Term] id: CL:1000838 name: kidney proximal convoluted tubule epithelial cell is_a: CL:0002306 ! epithelial cell of proximal tubule is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: BFO:0000050 UBERON:0001287 relationship: BFO:0000050 UBERON:0001287 [Term] id: CL:1000839 name: kidney proximal straight tubule epithelial cell is_a: CL:0002306 ! epithelial cell of proximal tubule is_a: CL:1000615 ! kidney cortex tubule cell is_a: CL:1000616 ! kidney outer medulla cell intersection_of: CL:0002306 ! epithelial cell of proximal tubule intersection_of: BFO:0000050 UBERON:0001290 relationship: BFO:0000050 UBERON:0001290 [Term] id: CL:1000849 name: kidney distal convoluted tubule epithelial cell is_a: CL:0002305 ! epithelial cell of distal tubule intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: BFO:0000050 UBERON:0001292 relationship: BFO:0000050 UBERON:0001292 [Term] id: CL:1000850 name: macula densa epithelial cell is_a: CL:0002305 ! epithelial cell of distal tubule is_a: CL:1000618 ! juxtaglomerular complex cell intersection_of: CL:0002305 ! epithelial cell of distal tubule intersection_of: BFO:0000050 UBERON:0002335 relationship: BFO:0000050 UBERON:0002335 [Term] id: CL:1000909 name: kidney loop of Henle epithelial cell is_a: CL:1000494 ! nephron tubule epithelial cell intersection_of: CL:1000494 ! nephron tubule epithelial cell intersection_of: BFO:0000050 UBERON:0001288 relationship: BFO:0000050 UBERON:0001288 [Term] id: CL:1000979 name: ureter smooth muscle cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000601 ! ureteral cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0006855 relationship: BFO:0000050 UBERON:0006855 [Term] id: CL:1001021 name: kidney loop of Henle descending limb epithelial cell is_a: CL:1000909 ! kidney loop of Henle epithelial cell intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell intersection_of: BFO:0000050 UBERON:0001289 relationship: BFO:0000050 UBERON:0001289 [Term] id: CL:1001111 name: kidney loop of Henle thin descending limb epithelial cell def: "An epithelial cell that is part of some loop of Henle thin descending limb." [] is_a: CL:0002518 ! kidney epithelial cell is_a: CL:1000616 ! kidney outer medulla cell is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell intersection_of: BFO:0000050 UBERON:0005096 relationship: BFO:0000050 UBERON:0005096 [Term] id: CL:1001225 name: kidney collecting duct cell def: "A cell that is part of a collecting duct of renal tubule." [] is_a: CL:1000497 ! kidney cell intersection_of: CL:1000497 ! kidney cell intersection_of: BFO:0000050 UBERON:0001232 [Term] id: CL:1001318 name: renal interstitial pericyte def: "A pericyte cell located in the kidney interstitium." [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0005215 [Term] id: CL:1001319 name: bladder cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001255 relationship: BFO:0000050 UBERON:0001255 [Term] id: CL:1001320 name: urethra cell is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000057 relationship: BFO:0000050 UBERON:0000057 [Term] id: CL:1001433 name: epithelial cell of exocrine pancreas def: "An epithelial cell of the exocrine pancreas." [] synonym: "exocrine pancreas cell" EXACT [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000017 [Term] id: CL:1001434 name: olfactory bulb interneuron def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [] is_a: CL:0000099 ! interneuron is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002264 relationship: BFO:0000050 UBERON:0002264 [Term] id: CL:1001451 name: sensory neuron of dorsal root ganglion def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [] synonym: "proprioceptive neuron" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:4023168 ! somatosensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0000044 relationship: BFO:0000050 UBERON:0000044 [Term] id: CL:1001474 name: medium spiny neuron def: "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." [] synonym: "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" EXACT [] synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT [] synonym: "medium-sized densely spiny neuron" RELATED [] synonym: "striatal medium spiny neuron" EXACT [] is_a: CL:0000617 ! GABAergic neuron relationship: RO:0002100 UBERON:0000369 relationship: RO:0002215 GO:0061534 [Term] id: CL:1001503 name: olfactory bulb tufted cell def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." [] is_a: CL:0000540 ! neuron relationship: BFO:0000050 UBERON:0005376 [Term] id: CL:1001509 name: glycinergic neuron def: "The neurons that utilize glycine as a neurotransmitter." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061537 [Term] id: CL:1001567 name: lung endothelial cell synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002048 relationship: BFO:0000050 UBERON:0000102 [Term] id: CL:1001568 name: pulmonary artery endothelial cell synonym: "PAEC cell" RELATED [] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002012 relationship: BFO:0000050 UBERON:0005317 [Term] id: CL:1001569 name: hippocampal interneuron def: "An interneuron with a soma found in the hippocampus." [] is_a: CL:0000099 ! interneuron is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002421 [Term] id: CL:1001571 name: hippocampal pyramidal neuron def: "A pyramidal neuron with a soma found in the hippocampus." [] synonym: "hippocampus (CA) pyramidal cell" NARROW [] synonym: "hippocampus (CA) pyramidal neuron" NARROW [] is_a: CL:0000598 ! pyramidal neuron is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0002421 relationship: BFO:0000050 UBERON:0002313 [Term] id: CL:1001572 name: colon endothelial cell def: "A vascular endothelial cell found in colon blood vessels." [] synonym: "colon endothelial cells" RELATED [] synonym: "colonic endothelial cell" RELATED [] is_a: CL:0000115 ! endothelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001155 relationship: BFO:0000050 UBERON:0013695 [Term] id: CL:1001575 name: uterine cervix squamous cell def: "Squamous cell of uterine cervix epithelium." [] synonym: "cervix squamous cell" RELATED [] synonym: "cervix squamous epithelial cell" RELATED [] synonym: "cervix, uterine squamous epithelial cells" RELATED [] synonym: "uterine cervix squamous epithelial cell" RELATED [] synonym: "uterine cervix squamous epithelial cells" RELATED [] is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0000002 relationship: BFO:0000050 UBERON:0004801 [Term] id: CL:1001578 name: vagina squamous cell def: "Squamous cell of vaginal epithelium." [] synonym: "vagina squamous epithelial cell" RELATED [] synonym: "vagina squamous epithelial cells" RELATED [] synonym: "vaginal squamous cell" RELATED [] synonym: "vaginal squamous epithelial cell" RELATED [] is_a: CL:0000076 ! squamous epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0000996 relationship: BFO:0000050 UBERON:0001344 [Term] id: CL:1001579 name: cerebral cortex glial cell def: "Glial cell of cerebral cortex." [] synonym: "brain cortex glial cell" RELATED [] synonym: "cerebral cortex glial cells" RELATED [] synonym: "cerebrum cortex glial cell" RELATED [] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0000956 [Term] id: CL:1001580 name: hippocampal glial cell def: "A glial cell that is part of the hippocampus." [] synonym: "hippocampus glial cell" EXACT [] synonym: "hippocampus neuroglial cell" EXACT [] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002421 [Term] id: CL:1001581 name: lateral ventricle glial cell def: "Glial cell of lateral ventricle." [] synonym: "lateral ventricle glial cells" RELATED [] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002285 [Term] id: CL:1001582 name: lateral ventricle neuron def: "Neuron of lateral ventricle." [] synonym: "lateral ventricle neural cell" RELATED [] synonym: "lateral ventricle neuronal cell" RELATED [] synonym: "lateral ventricle neuronal cells" RELATED [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002285 [Term] id: CL:1001586 name: mammary gland glandular cell def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [] synonym: "breast glandular cell" RELATED [] synonym: "breast glandular cells" RELATED [] synonym: "mammary glandular cell" RELATED [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002327 ! mammary gland epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001911 relationship: BFO:0000050 UBERON:0003244 [Term] id: CL:1001587 name: uterine cervix glandular cell def: "Glandular cell of uterine cervix epithelium." [] synonym: "cervix glandular cell" RELATED [] synonym: "cervix, uterine glandular cell" RELATED [] synonym: "cervix, uterine glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002535 ! epithelial cell of cervix intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000002 relationship: BFO:0000050 UBERON:0004801 [Term] id: CL:1001588 name: colon glandular cell def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [] synonym: "colon glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0011108 ! colon epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001155 relationship: BFO:0000050 UBERON:0000397 [Term] id: CL:1001590 name: epididymis glandular cell def: "Glandular cell of epididymal epithelium." [] synonym: "epididymal glandular cell" RELATED [] synonym: "epididymis glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001301 relationship: BFO:0000050 UBERON:0004544 [Term] id: CL:1001591 name: oviduct glandular cell def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [] synonym: "fallopian tube glandular cell" RELATED [] synonym: "fallopian tube glandular cells" RELATED [] synonym: "uterine tube glandular cell" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000993 relationship: BFO:0000050 UBERON:0004804 [Term] id: CL:1001592 name: gallbladder glandular cell def: "Glandular cell of gallbladder epithelium." [] synonym: "gall bladder glandular cell" EXACT [] synonym: "gall bladder glandular cells" RELATED [] synonym: "gallbladder glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1000415 ! epithelial cell of gallbladder intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0002110 relationship: BFO:0000050 UBERON:0002029 [Term] id: CL:1001593 name: parathyroid glandular cell def: "Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells." [] synonym: "parathyroid gland glandular cell" RELATED [] synonym: "parathyroid gland glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001132 relationship: BFO:0000050 UBERON:0011197 [Term] id: CL:1001596 name: salivary gland glandular cell def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [] synonym: "salivary gland glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001044 relationship: BFO:0000050 UBERON:0004809 [Term] id: CL:1001597 name: seminal vesicle glandular cell def: "Glandular cell of seminal vesicle epithelium." [] synonym: "seminal vesicle glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000998 relationship: BFO:0000050 UBERON:0004805 [Term] id: CL:1001598 name: small intestine glandular cell def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [] synonym: "small bowel glandular cell" RELATED [] synonym: "small intestinal glandular cell" RELATED [] synonym: "small intestine glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0002108 relationship: BFO:0000050 UBERON:0001902 [Term] id: CL:1001599 name: pancreas exocrine glandular cell def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [] synonym: "exocrine pancreas glandular cell" RELATED [] synonym: "pancreas exocrine glandular cells" RELATED [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0000017 relationship: BFO:0000050 UBERON:0013697 [Term] id: CL:1001601 name: adrenal gland glandular cell def: "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens." [] synonym: "adrenal gland glandular cells" RELATED [] synonym: "adrenal glandular cell" RELATED [] synonym: "suprarenal gland glandular cell" RELATED [] is_a: CL:0000150 ! glandular epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001235 [Term] id: CL:1001602 name: cerebral cortex endothelial cell def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." [] synonym: "cerebral cortex endothelial cells" RELATED [] synonym: "endothelial cells of cerebral cortex" RELATED [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000956 relationship: BFO:0000050 UBERON:0013694 [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [] synonym: "lung macrophages" RELATED [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0002048 [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001630 [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [] synonym: "bone marrow hematopoietic cells" RELATED [] synonym: "bone marrow poietic cells" RELATED [] is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: BFO:0000050 UBERON:0002371 relationship: BFO:0000050 UBERON:0012429 [Term] id: CL:1001611 name: cerebellar neuron def: "Neuron of the cerebellum." [] synonym: "cerebellum neuron" RELATED [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002037 [Term] id: CL:2000000 name: epidermal melanocyte def: "Any melanocyte that is part of a epidermis." [] is_a: CL:0000148 ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: BFO:0000050 UBERON:0001003 [Term] id: CL:2000004 name: pituitary gland cell def: "Any cell that is part of a pituitary gland." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000007 [Term] id: CL:2000005 name: brain macroglial cell def: "Any macroglial cell that is part of a brain." [] is_a: CL:0000126 ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: BFO:0000050 UBERON:0000955 [Term] id: CL:2000018 name: endothelial cell of coronary artery def: "Any endothelial cell of artery that is part of a coronary artery." [] is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: BFO:0000050 UBERON:0001621 [Term] id: CL:2000019 name: compound eye photoreceptor cell def: "Any photoreceptor cell that is part of a compound eye." [] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000018 [Term] id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000087 [Term] id: CL:2000021 name: sebaceous gland cell def: "Any native cell that is part of a sebaceous gland." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001821 [Term] id: CL:2000022 name: cardiac septum cell def: "Any native cell that is part of a cardiac septum." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002099 [Term] id: CL:2000025 name: spinal cord oligodendrocyte def: "Any oligodendrocyte that is part of a spinal cord." [] is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000128 ! oligodendrocyte intersection_of: BFO:0000050 UBERON:0002240 [Term] id: CL:2000028 name: cerebellum glutamatergic neuron def: "Any glutamatergic neuron that is part of a cerebellum." [] is_a: CL:0000679 ! glutamatergic neuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0002100 UBERON:0002037 [Term] id: CL:2000029 name: central nervous system neuron def: "Any neuron that is part of a central nervous system." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 [Term] id: CL:2000030 name: hypothalamus cell def: "Any native cell that is part of a hypothalamus." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001898 [Term] id: CL:2000031 name: lateral line ganglion neuron def: "Any neuron that is part of a lateral line ganglion." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:2000120 [Term] id: CL:2000032 name: peripheral nervous system neuron def: "A neuron that is part of a peripheral nervous system." [] synonym: "peripheral neuron" EXACT [] synonym: "PNS neuron" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 [Term] id: CL:2000033 name: limb basal cell of epidermis def: "Any basal cell of epidermis that is part of a limb." [] is_a: CL:0002187 ! basal cell of epidermis intersection_of: CL:0002187 ! basal cell of epidermis intersection_of: BFO:0000050 UBERON:0002101 [Term] id: CL:2000034 name: anterior lateral line neuromast hair cell def: "Any neuromast hair cell that is part of a anterior lateral line." [] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: BFO:0000050 UBERON:2001470 [Term] id: CL:2000035 name: anterior lateral line neuromast mantle cell def: "Any neuromast mantle cell that is part of an anterior lateral line." [] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: BFO:0000050 UBERON:2001470 [Term] id: CL:2000036 name: anterior lateral line neuromast supporting cell def: "Any neuromast support cell that is part of a anterior lateral line." [] synonym: "anterior lateral line neuromast support cell" EXACT [] is_a: CL:0000852 ! neuromast supporting cell intersection_of: CL:0000852 ! neuromast supporting cell intersection_of: BFO:0000050 UBERON:2001470 [Term] id: CL:2000037 name: posterior lateral line neuromast hair cell def: "Any neuromast hair cell that is part of a posterior lateral line." [] is_a: CL:0000856 ! neuromast hair cell intersection_of: CL:0000856 ! neuromast hair cell intersection_of: BFO:0000050 UBERON:0006334 [Term] id: CL:2000038 name: posterior lateral line neuromast mantle cell def: "Any neuromast mantle cell that is part of a posterior lateral line." [] is_a: CL:0000851 ! neuromast mantle cell intersection_of: CL:0000851 ! neuromast mantle cell intersection_of: BFO:0000050 UBERON:0006334 [Term] id: CL:2000039 name: posterior lateral line neuromast supporting cell def: "Any neuromast support cell that is part of a posterior lateral line." [] synonym: "posterior lateral line neuromast support cell" EXACT [] is_a: CL:0000852 ! neuromast supporting cell intersection_of: CL:0000852 ! neuromast supporting cell intersection_of: BFO:0000050 UBERON:0006334 [Term] id: CL:2000042 name: embryonic fibroblast def: "Any fibroblast that is part of a embryo." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000922 [Term] id: CL:2000043 name: brain pericyte def: "Any pericyte cell that is part of a brain." [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0000955 [Term] id: CL:2000046 name: ventricular cardiac muscle cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: BFO:0000050 UBERON:0002082 [Term] id: CL:2000047 name: brainstem motor neuron def: "Any motor neuron that is part of a brainstem." [] is_a: CL:0000100 ! motor neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 [Term] id: CL:2000049 name: primary motor cortex pyramidal cell def: "Any pyramidal cell that is part of a primary motor cortex." [] is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0001384 [Term] id: CL:2000051 name: splenic fibroblast def: "Any fibroblast that is part of a spleen." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002106 [Term] id: CL:2000052 name: umbilical artery endothelial cell def: "Any endothelial cell of artery that is part of a umbilical cord." [] is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:1000413 ! endothelial cell of artery intersection_of: BFO:0000050 UBERON:0002331 [Term] id: CL:2000053 name: splenic endothelial cell def: "Any endothelial cell that is part of a spleen." [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002106 [Term] id: CL:2000055 name: liver dendritic cell def: "Any dendritic cell that is part of a liver." [] synonym: "hepatic dendritic cell" EXACT [] is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: BFO:0000050 UBERON:0002107 [Term] id: CL:2000056 name: Meynert cell def: "Any pyramidal cell that is part of a regional part of cerebral cortex." [] is_a: CL:2000049 ! primary motor cortex pyramidal cell relationship: RO:0002100 UBERON:0001384 [Term] id: CL:2000061 name: placental amniotic mesenchymal stromal cell def: "Any mesenchymal stem cell that is part of a placenta." [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:2000063 name: ovarian fibroblast def: "Any fibroblast that is part of a female gonad." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000992 [Term] id: CL:2000064 name: ovarian surface epithelial cell def: "Any epithelial cell that is part of a female gonad." [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000992 [Term] id: CL:2000066 name: cardiac ventricle fibroblast def: "Any fibroblast that is part of a cardiac ventricle." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002082 [Term] id: CL:2000067 name: cardiac atrium fibroblast def: "Any fibroblast that is part of a cardiac atrium." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002081 [Term] id: CL:2000068 name: pericardium fibroblast def: "Any fibroblast that is part of a pericardium." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002407 [Term] id: CL:2000069 name: gallbladder fibroblast def: "Any fibroblast that is part of a gallbladder." [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002110 [Term] id: CL:2000073 name: migratory cardiac neural crest cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [] synonym: "cardiac neural crest cell" EXACT [] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: BFO:0000050 UBERON:0000095 [Term] id: CL:2000074 name: splenocyte def: "Any leukocyte that is part of a spleen." [] is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000050 UBERON:0002106 [Term] id: CL:2000075 name: anterior visceral endoderm cell def: "Any endodermal cell that is part of a anterior visceral endoderm." [] is_a: CL:0000223 ! endodermal cell intersection_of: CL:0000223 ! endodermal cell intersection_of: BFO:0000050 UBERON:0004044 [Term] id: CL:2000078 name: placental pericyte def: "Any pericyte cell that is part of a placenta." [] is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0001987 [Term] id: CL:2000085 name: mononuclear cell of umbilical cord def: "Any mononuclear cell that is part of a umbilical cord." [] is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell intersection_of: BFO:0000050 UBERON:0002331 [Term] id: CL:2000089 name: dentate gyrus granule cell def: "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." [] synonym: "dentate gyrus of hippocampal formation granule cell" EXACT [] is_a: CL:0001033 ! hippocampal granule cell intersection_of: CL:0001033 ! hippocampal granule cell intersection_of: RO:0002100 UBERON:0005381 [Term] id: CL:2000090 name: dentate gyrus of hippocampal formation stellate cell def: "Any stellate cell that is part of a dentate gyrus of hippocampal formation." [] is_a: CL:0000122 ! stellate neuron is_a: CL:4023062 ! dentate gyrus neuron intersection_of: CL:0000122 ! stellate neuron intersection_of: RO:0002100 UBERON:0001885 [Term] id: CL:2000092 name: hair follicular keratinocyte def: "Any keratinocyte that is part of a hair follicle." [] is_a: CL:0000312 ! keratinocyte is_a: CL:0002559 ! hair follicle cell intersection_of: CL:0000312 ! keratinocyte intersection_of: BFO:0000050 UBERON:0002073 [Term] id: CL:2000093 name: bronchus fibroblast of lung def: "Any fibroblast of lung that is part of a bronchus." [] is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: BFO:0000050 UBERON:0002185 [Term] id: CL:2000097 name: midbrain dopaminergic neuron def: "Any dopaminergic neuron that is part of a midbrain." [] is_a: CL:0000700 ! dopaminergic neuron intersection_of: CL:0000700 ! dopaminergic neuron intersection_of: RO:0002100 UBERON:0001891 [Term] id: CL:3000002 name: sympathetic noradrenergic neuron def: "Sympathetic noradrenergic neuron." [] is_a: CL:0008025 ! noradrenergic neuron is_a: CL:0011103 ! sympathetic neuron intersection_of: CL:0011103 ! sympathetic neuron intersection_of: RO:0002215 GO:0061533 [Term] id: CL:3000003 name: sympathetic cholinergic neuron def: "Sympathetic cholinergic neuron." [] is_a: CL:0000108 ! cholinergic neuron is_a: CL:0011103 ! sympathetic neuron intersection_of: CL:0011103 ! sympathetic neuron intersection_of: RO:0002215 GO:0014055 [Term] id: CL:3000004 name: peripheral sensory neuron def: "Peripheral sensory neuron." [] is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002215 GO:0050906 [Term] id: CL:4023039 name: amygdala excitatory neuron is_a: CL:0000679 ! glutamatergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001876 intersection_of: RO:0002215 GO:0061535 [Term] id: CL:4023057 name: cerebellar inhibitory GABAergic interneuron is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: RO:0002100 UBERON:0002129 [Term] id: CL:4023062 name: dentate gyrus neuron def: "A neuron with its soma located in the dentate gyrus of the hippocampus." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001885 [Term] id: CL:4023074 name: mammillary body neuron def: "A neuron that has its soma located in the mammillary body." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002206 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron def: "A GABAergic inhibitory neuron that is derived from the midbrain." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0001891 [Term] id: CL:4023110 name: amygdala pyramidal neuron def: "A pyramidal neuron with soma located in the amygdala." [] is_a: CL:0000598 ! pyramidal neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0001876 [Term] id: CL:4023111 name: cerebral cortex pyramidal neuron def: "A pyramidal neuron with soma located in the cerebral cortex." [] is_a: CL:0000598 ! pyramidal neuron is_a: CL:0010012 ! cerebral cortex neuron intersection_of: CL:0000598 ! pyramidal neuron intersection_of: RO:0002100 UBERON:0000956 [Term] id: CL:4023120 name: cochlea auditory hair cell def: "An auditory hair cell found in the cochlea." [] synonym: "cochlear hair cell" EXACT [] is_a: CL:0000202 ! auditory hair cell intersection_of: CL:0000202 ! auditory hair cell intersection_of: BFO:0000050 UBERON:0002227 [Term] id: CL:4023154 name: myelinating glial cell def: "A glial cell that myelinates axonal processes." [] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000051 GO:0043209 [Term] id: CL:4023168 name: somatosensory neuron def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: BFO:0000050 UBERON:0003942 [Term] id: CL:4029001 name: gamete-nursing cell def: "A cell that supports the development of a gamete by providing it cytoplasmic material (including entire organelles) by direct cross-membrane channels (del Pino, 2021)." [] is_a: CL:0000000 ! cell [Term] id: CL:4029002 name: germline-derived nurse cell def: "A gamete-nursing cell that derives from a germline cell (del Pino, 2021)." [] is_a: CL:0000039 ! germ line cell is_a: CL:4029001 ! gamete-nursing cell [Term] id: CL:4030001 name: stromal cell of thymus def: "A stromal cell that is part of the thymus." [] synonym: "thymic stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002370 [Term] id: CL:4030008 name: pronephric podocyte def: "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros." [] synonym: "pronephric glomerular visceral epithelial cell" EXACT [] is_a: CL:0000653 ! podocyte intersection_of: CL:0000653 ! podocyte intersection_of: BFO:0000050 UBERON:0002120 [Term] id: CL:4030012 name: kidney loop of Henle short descending thin limb epithelial cell def: "Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2." [] synonym: "epithelial cell of the descending thin limb of the short loop of Henle" EXACT [] is_a: CL:1001111 ! kidney loop of Henle thin descending limb epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005099 [Term] id: CL:4030016 name: epithelial cell of early distal convoluted tubule def: "An epithelial cell located in the early distal convoluted tubule." [] synonym: "DCT1 cell" BROAD [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005101 [Term] id: CL:4030017 name: epithelial cell of late distal convoluted tubule def: "An epithelial cell located in the late distal convoluted tubule." [] synonym: "DCT2 cell" BROAD [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0005102 [Term] id: CL:4030027 name: GABAergic amacrine cell def: "An amacrine cell that uses GABA as a neurotransmitter." [] synonym: "amacrine cell, GABAergic" EXACT [] is_a: CL:0000561 ! amacrine cell is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0002215 GO:0061534 [Term] id: CL:4030028 name: glycinergic amacrine cell def: "An amacrine cell that uses glycine as a neurotransmitter." [] synonym: "amacrine cell, glycinergic" EXACT [] is_a: CL:0000561 ! amacrine cell is_a: CL:1001509 ! glycinergic neuron intersection_of: CL:0000561 ! amacrine cell intersection_of: RO:0002215 GO:0061537 [Term] id: CL:4030033 name: valve endothelial cell def: "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [] synonym: "valvular endothelial cell" EXACT [] synonym: "VEC" EXACT [] is_a: CL:0000115 ! endothelial cell is_a: CL:1000147 ! cardiac valve cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000946 [Term] id: CL:4030034 name: respiratory ciliated cell def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." [] synonym: "ciliated cell of the respiratory tract" EXACT [] is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0004802 relationship: BFO:0000050 UBERON:0001004 [Term] id: CL:4030035 name: dental pulp stem cell def: "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." [] synonym: "DPSC" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0002148 ! dental pulp cell intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0001754 [Term] id: CL:4030058 name: TCR-positive macrophage def: "A macrophage that expresses the T cell receptor complex at the cell surface." [] synonym: "T cell receptor positive macrophage" EXACT [] synonym: "TCR+ macrophage" EXACT [] synonym: "TCR.macs" RELATED [] is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0002104 GO:0042101 [Term] id: CL:4030066 name: ureteric bud cell def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." [] synonym: "UB cell" RELATED [] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000084 relationship: RO:0000056 GO:2001013 [Term] id: CL:4033008 name: vein endothelial cell of respiratory system def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0001004 [Term] id: CL:4033009 name: goblet cell of epithelium of lobar bronchus def: "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus." [] is_a: CL:0000160 ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: BFO:0000050 UBERON:0002339 [Term] id: CL:4033010 name: neuroendocrine cell of epithelium of lobar bronchus def: "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus." [] is_a: CL:0000165 ! neuroendocrine cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002339 [Term] id: CL:4033015 name: retinal astrocyte def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." [] synonym: "retinal astroglia" RELATED [] is_a: CL:0000127 ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0000966 [Term] id: CL:4033017 name: bronchiolar smooth muscle cell def: "A smooth muscle cell that is part of a bronchiole." [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002186 relationship: BFO:0000050 UBERON:0004515 [Term] id: CL:4033018 name: lung megakaryocyte def: "A megakaryocyte that is resident in the lung connective tissue." [] synonym: "lung MKs" RELATED [] synonym: "lung resident megakaryocyte" EXACT [] synonym: "lung-resident megakaryocyte" EXACT [] synonym: "MKL" RELATED [] is_a: CL:0000556 ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: BFO:0000050 UBERON:0000114 [Term] id: CL:4033020 name: mucus secreting cell of trachea gland def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [] synonym: "tracheal submucosal gland mucous cell" EXACT [] is_a: CL:0000319 ! mucus secreting cell intersection_of: CL:0000319 ! mucus secreting cell intersection_of: BFO:0000050 UBERON:0005203 [Term] id: CL:4033050 name: catecholaminergic neuron def: "A neuron that releases catecholamine as a neurotransmitter." [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0160043 [Term] id: CL:4033054 name: perivascular cell def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002220 UBERON:0002049 [Term] id: CL:4033057 name: luminal adaptive secretory precursor cell of mammary gland def: "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." [] synonym: "alveolar cell" BROAD [] synonym: "alveolar progenitor" BROAD [] synonym: "AP" RELATED [] synonym: "AV" RELATED [] synonym: "ER-negative luminal alveolar progenitor" EXACT [] synonym: "LASP" RELATED [] synonym: "LP" RELATED [] synonym: "luminal progenitor" BROAD [] synonym: "luminal progenitor cell" BROAD [] synonym: "luminal secretory cell" BROAD [] synonym: "LumSec" RELATED [] is_a: CL:0002326 ! luminal epithelial cell of mammary gland is_a: CL:0011115 ! precursor cell [Term] id: CL:4033064 name: uterine resident macrophage def: "A tissue-resident macrophage that is part of the uterus." [] synonym: "uterine macrophage" BROAD [] is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0000995 [Term] id: CL:4040002 name: enteroglial cell def: "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP)." [] synonym: "enteric glia" RELATED [] synonym: "enteric glial cell" EXACT [] is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002005 relationship: RO:0002292 PR:000007939 [Term] id: CL:4040003 name: fetal pre-type II pneumocyte def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." [] synonym: "fetal alveolar pre-type II epithelial cell" EXACT [] synonym: "fetal pre-type 2 pneumocyte" EXACT [] synonym: "fetal pre-type II alveolar epithelial cell" EXACT [] is_a: CL:0000322 ! pneumocyte [Typedef] id: BFO:0000050 xref: BFO:0000050 [Typedef] id: BFO:0000051 xref: BFO:0000051 [Typedef] id: RO:0000053 xref: RO:0000053 [Typedef] id: RO:0000056 xref: RO:0000056 [Typedef] id: RO:0001025 xref: RO:0001025 [Typedef] id: RO:0002100 xref: RO:0002100 [Typedef] id: RO:0002102 xref: RO:0002102 [Typedef] id: RO:0002103 xref: RO:0002103 [Typedef] id: RO:0002104 xref: RO:0002104 [Typedef] id: RO:0002120 xref: RO:0002120 [Typedef] id: RO:0002160 xref: RO:0002160 [Typedef] id: RO:0002162 xref: RO:0002162 [Typedef] id: RO:0002202 xref: RO:0002202 [Typedef] id: RO:0002203 xref: RO:0002203 [Typedef] id: RO:0002207 xref: RO:0002207 [Typedef] id: RO:0002215 xref: RO:0002215 [Typedef] id: RO:0002216 xref: RO:0002216 [Typedef] id: RO:0002220 xref: RO:0002220 [Typedef] id: RO:0002292 xref: RO:0002292 [Typedef] id: RO:0002339 xref: RO:0002339 [Typedef] id: RO:0002353 xref: RO:0002353 [Typedef] id: RO:0003000 xref: RO:0003000 [Typedef] id: RO:0015015 xref: RO:0015015 [Typedef] id: RO:0015016 xref: RO:0015016 [Typedef] id: has_not_completed name: has_not_completed xref: CL:4030044 [Typedef] id: lacks_part name: lacks_part xref: CL:4030045 [Typedef] id: lacks_plasma_membrane_part name: lacks_plasma_membrane_part xref: CL:4030046