format-version: 1.2 data-version: go/releases/2024-02-12/imports/ro_import.owl ontology: go/imports/ro_import [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] relationship: part_of BFO:0000003 ! occurrent [Term] id: BFO:0000004 name: independent continuant def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000004 ! independent continuant [Term] id: BFO:0000015 name: process def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role [Term] id: BFO:0000017 name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 ! realizable entity [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality [Term] id: BFO:0000020 name: specifically dependent continuant def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000020 ! specifically dependent continuant [Term] id: BFO:0000023 name: role def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] is_a: BFO:0000017 ! realizable entity [Term] id: BFO:0000034 name: function is_a: BFO:0000016 ! disposition [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant [Term] id: CHEBI:50906 is_a: PATO:0000001 [Typedef] id: acts_on_population_of name: acts on population of def: "p acts on population of c iff c' is a collection, has members of type c, and p has participant c" [] xref: RO:0012003 is_a: has_participant ! has participant [Typedef] id: acts_upstream_of name: acts upstream of def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." [] xref: RO:0002263 holds_over_chain: enables causally_upstream_of is_a: acts_upstream_of_or_within ! acts upstream of or within [Typedef] id: acts_upstream_of,_negative_effect name: acts upstream of, negative effect def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" [] xref: RO:0004035 holds_over_chain: enables causally_upstream_of,_negative_effect is_a: acts_upstream_of ! acts upstream of is_a: acts_upstream_of_or_within,_negative_effect ! acts upstream of or within, negative effect [Typedef] id: acts_upstream_of,_positive_effect name: acts upstream of, positive effect def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" [] xref: RO:0004034 holds_over_chain: enables causally_upstream_of,_positive_effect is_a: acts_upstream_of ! acts upstream of is_a: acts_upstream_of_or_within,_positive_effect ! acts upstream of or within, positive effect [Typedef] id: acts_upstream_of_or_within name: acts upstream of or within def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." [] synonym: "affects" RELATED [] xref: RO:0002264 holds_over_chain: enables causally_upstream_of_or_within is_a: causal_agent_in_process ! causal agent in process [Typedef] id: acts_upstream_of_or_within,_negative_effect name: acts upstream of or within, negative effect xref: RO:0004033 holds_over_chain: enables causally_upstream_of_or_within,_negative_effect is_a: acts_upstream_of_or_within ! acts upstream of or within [Typedef] id: acts_upstream_of_or_within,_positive_effect name: acts upstream of or within, positive effect xref: RO:0004032 holds_over_chain: enables causally_upstream_of_or_within,_positive_effect is_a: acts_upstream_of_or_within ! acts upstream of or within [Typedef] id: adjacent_to name: adjacent to def: "x adjacent to y if and only if x and y share a boundary." [] xref: RO:0002220 domain: BFO:0000004 ! independent continuant range: BFO:0000004 ! independent continuant is_a: spatially_disjoint_from ! spatially disjoint from [Typedef] id: bounding_layer_of name: bounding layer of def: "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" [] xref: RO:0002007 range: BFO:0000040 ! material entity is_a: part_of ! part of [Typedef] id: capable_of name: capable of def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] xref: RO:0002215 domain: BFO:0000004 ! independent continuant range: BFO:0000015 ! process is_a: capable_of_part_of ! capable of part of [Typedef] id: capable_of_negatively_regulating name: capable of negatively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] xref: RO:0002597 holds_over_chain: capable_of negatively_regulates is_a: capable_of_regulating ! capable of regulating [Typedef] id: capable_of_part_of name: capable of part of def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] xref: RO:0002216 holds_over_chain: capable_of part_of is_a: causal_agent_in_process ! causal agent in process is_a: functionally_related_to ! functionally related to [Typedef] id: capable_of_positively_regulating name: capable of positively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] xref: RO:0002598 holds_over_chain: capable_of positively_regulates is_a: capable_of_regulating ! capable of regulating [Typedef] id: capable_of_regulating name: capable of regulating def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] xref: RO:0002596 holds_over_chain: capable_of regulates is_a: causal_agent_in_process ! causal agent in process [Typedef] id: causal_agent_in_process name: causal agent in process def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] xref: RO:0002500 is_a: causal_relation_between_material_entity_and_a_process ! causal relation between material entity and a process inverse_of: process_has_causal_agent ! process has causal agent [Typedef] id: causal_relation_between_entities name: causal relation between entities xref: RO:0002506 domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: causally_related_to ! causally related to [Typedef] id: causal_relation_between_material_entity_and_a_process name: causal relation between material entity and a process def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] xref: RO:0002595 domain: BFO:0000040 ! material entity range: BFO:0000015 ! process is_a: causally_related_to ! causally related to [Typedef] id: causal_relation_between_processes name: causal relation between processes def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." [] xref: RO:0002501 domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: causally_related_to ! causally related to [Typedef] id: causally_downstream_of name: causally downstream of def: "inverse of upstream of" [] xref: RO:0002404 is_a: causally_downstream_of_or_within ! causally downstream of or within is_a: preceded_by ! preceded by inverse_of: causally_upstream_of ! causally upstream of [Typedef] id: causally_downstream_of_or_within name: causally downstream of or within def: "inverse of causally upstream of or within" [] xref: RO:0002427 is_transitive: true is_a: causal_relation_between_processes ! causal relation between processes [Typedef] id: causally_influenced_by name: causally influenced by xref: RO:0002559 is_a: causal_relation_between_entities ! causal relation between entities inverse_of: causally_influences ! causally influences [Typedef] id: causally_influences name: causally influences def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." [] xref: RO:0002566 domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: causal_relation_between_entities ! causal relation between entities [Typedef] id: causally_related_to name: causally related to def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [] xref: RO:0002410 [Typedef] id: causally_upstream_of name: causally upstream of def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." [] xref: RO:0002411 is_transitive: true is_a: causally_upstream_of_or_within ! causally upstream of or within is_a: precedes ! precedes [Typedef] id: causally_upstream_of,_negative_effect name: causally upstream of, negative effect def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." [] xref: RO:0002305 is_a: causally_upstream_of ! causally upstream of is_a: causally_upstream_of_or_within,_negative_effect ! causally upstream of or within, negative effect [Typedef] id: causally_upstream_of,_positive_effect name: causally upstream of, positive effect def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." [] xref: RO:0002304 is_a: causally_upstream_of ! causally upstream of is_a: causally_upstream_of_or_within,_positive_effect ! causally upstream of or within, positive effect [Typedef] id: causally_upstream_of_or_within name: causally upstream of or within def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." [] synonym: "affects" RELATED [] xref: RO:0002418 is_transitive: true is_a: causal_relation_between_processes ! causal relation between processes inverse_of: causally_downstream_of_or_within ! causally downstream of or within [Typedef] id: causally_upstream_of_or_within,_negative_effect name: causally upstream of or within, negative effect xref: RO:0004046 is_a: causally_upstream_of_or_within ! causally upstream of or within [Typedef] id: causally_upstream_of_or_within,_positive_effect name: causally upstream of or within, positive effect xref: RO:0004047 is_a: causally_upstream_of_or_within ! causally upstream of or within [Typedef] id: characteristic_of name: characteristic of def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] xref: RO:0000052 is_functional: true is_a: characteristic_of_part_of ! characteristic of part of inverse_of: has_characteristic ! has characteristic [Typedef] id: characteristic_of_part_of name: characteristic of part of def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] xref: RO:0002314 holds_over_chain: characteristic_of part_of is_a: depends_on ! depends on transitive_over: part_of ! part of [Typedef] id: coincident_with name: coincident with def: "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other." [] xref: RO:0002008 is_a: mereotopologically_related_to ! mereotopologically related to [Typedef] id: contains_process name: contains process def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] xref: BFO:0000067 [Typedef] id: depends_on name: depends on xref: RO:0002502 [Typedef] id: developmentally_contributes_to name: developmentally contributes to def: "inverse of has developmental contribution from" [] xref: RO:0002255 holds_over_chain: develops_into part_of is_a: developmentally_succeeded_by ! developmentally succeeded by is_a: has_potential_to_developmentally_contribute_to ! has potential to developmentally contribute to [Typedef] id: developmentally_preceded_by name: developmentally preceded by def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" [] xref: RO:0002258 domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: developmentally_related_to ! developmentally related to inverse_of: developmentally_succeeded_by ! developmentally succeeded by [Typedef] id: developmentally_related_to name: developmentally related to def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" [] xref: RO:0002324 [Typedef] id: developmentally_succeeded_by name: developmentally succeeded by def: "Inverse of developmentally preceded by" [] xref: RO:0002286 is_a: has_developmental_potential_involving ! has developmental potential involving [Typedef] id: develops_from name: develops from def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" [] xref: RO:0002202 domain: BFO:0000004 ! independent continuant range: BFO:0000004 ! independent continuant is_transitive: true is_a: developmentally_preceded_by ! developmentally preceded by inverse_of: develops_into ! develops into [Typedef] id: develops_into name: develops into def: "inverse of develops from" [] xref: RO:0002203 is_transitive: true is_a: developmentally_succeeded_by ! developmentally succeeded by is_a: has_potential_to_develop_into ! has potential to develop into is_a: has_potential_to_directly_develop_into ! has potential to directly develop into [Typedef] id: device_utilizes_material name: device utilizes material def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." [] synonym: "utilizes" BROAD [] xref: RO:0017001 holds_over_chain: capable_of has_input [Typedef] id: directly_negatively_regulated_by name: directly negatively regulated by def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [] xref: RO:0002023 is_a: directly_regulated_by ! directly regulated by inverse_of: directly_negatively_regulates ! directly negatively regulates [Typedef] id: directly_negatively_regulates name: directly negatively regulates def: "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." [] xref: RO:0002630 is_a: directly_regulates ! directly regulates is_a: negatively_regulates ! negatively regulates [Typedef] id: directly_negatively_regulates_activity_of name: directly negatively regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." [] synonym: "molecularly decreases activity of" EXACT [] xref: RO:0002449 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: directly_regulates_activity_of ! directly regulates activity of [Typedef] id: directly_positively_regulated_by name: directly positively regulated by def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [] xref: RO:0002024 is_a: directly_regulated_by ! directly regulated by inverse_of: directly_positively_regulates ! directly positively regulates [Typedef] id: directly_positively_regulates name: directly positively regulates def: "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." [] xref: RO:0002629 is_a: directly_regulates ! directly regulates is_a: positively_regulates ! positively regulates [Typedef] id: directly_positively_regulates_activity_of name: directly positively regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." [] synonym: "molecularly increases activity of" EXACT [] xref: RO:0002450 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: directly_regulates_activity_of ! directly regulates activity of [Typedef] id: directly_regulated_by name: directly regulated by xref: RO:0002022 is_a: regulated_by ! regulated by inverse_of: directly_regulates ! directly regulates [Typedef] id: directly_regulates name: directly regulates def: "p directly regulates q iff p is immediately causally upstream of q and p regulates q." [] xref: RO:0002578 is_a: immediately_causally_upstream_of ! immediately causally upstream of is_a: regulates ! regulates [Typedef] id: directly_regulates_activity_of name: directly regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." [] synonym: "molecularly controls" EXACT [] xref: RO:0002448 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: molecularly_interacts_with ! molecularly interacts with is_a: regulates_activity_of ! regulates activity of [Typedef] id: disposition_of name: disposition of def: "inverse of has disposition" [] xref: RO:0000092 is_a: characteristic_of ! characteristic of [Typedef] id: during_which_ends name: during which ends xref: RO:0002084 is_a: temporally_related_to ! temporally related to inverse_of: ends_during ! ends during [Typedef] id: during_which_starts name: during which starts xref: RO:0002088 is_a: temporally_related_to ! temporally related to inverse_of: starts_during ! starts during [Typedef] id: enabled_by name: enabled by def: "inverse of enables" [] xref: RO:0002333 is_a: functionally_related_to ! functionally related to is_a: has_participant ! has participant [Typedef] id: enables name: enables def: "c enables p iff c is capable of p and c acts to execute p." [] xref: RO:0002327 is_a: capable_of ! capable of inverse_of: enabled_by ! enabled by transitive_over: has_component_activity ! has component activity transitive_over: has_part ! has part [Typedef] id: enables_subfunction name: enables subfunction def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." [] xref: RO:0004031 holds_over_chain: enables has_part is_a: functionally_related_to ! functionally related to [Typedef] id: encompasses name: encompasses xref: RO:0002085 is_transitive: true is_a: during_which_starts ! during which starts inverse_of: happens_during ! happens during [Typedef] id: ends name: ends def: "inverse of ends with" [] xref: RO:0002229 is_a: part_of ! part of is_a: temporally_related_to ! temporally related to inverse_of: ends_with ! ends with [Typedef] id: ends_after name: ends after xref: RO:0002086 holds_over_chain: ends_during preceded_by is_transitive: true is_a: temporally_related_to ! temporally related to [Typedef] id: ends_during name: ends during xref: RO:0002093 is_a: temporally_related_to ! temporally related to [Typedef] id: ends_with name: ends with def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] xref: RO:0002230 is_transitive: true is_a: has_part ! has part is_a: temporally_related_to ! temporally related to [Typedef] id: evolutionarily_related_to name: evolutionarily related to def: "A relationship that holds via some environmental process" [] xref: RO:0002320 [Typedef] id: formed_as_result_of name: formed as result of xref: RO:0002354 is_a: output_of ! output of [Typedef] id: function_of name: function of def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" [] xref: RO:0000079 domain: BFO:0000034 ! function is_a: characteristic_of ! characteristic of inverse_of: has_function ! has function [Typedef] id: functionally_related_to name: functionally related to def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." [] xref: RO:0002328 [Typedef] id: happens_during name: happens during xref: RO:0002092 is_transitive: true is_a: ends_during ! ends during is_a: starts_during ! starts during [Typedef] id: has_characteristic name: has characteristic def: "Inverse of characteristic_of" [] xref: RO:0000053 range: BFO:0000020 ! specifically dependent continuant is_inverse_functional: true [Typedef] id: has_component name: has component def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] xref: RO:0002180 is_a: has_part ! has part [Typedef] id: has_component_activity name: has component activity xref: RO:0002017 is_a: has_component_process ! has component process [Typedef] id: has_component_process name: has component process def: "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] xref: RO:0002018 domain: BFO:0000015 ! process range: BFO:0000015 ! process is_a: has_component ! has component [Typedef] id: has_developmental_contribution_from name: has developmental contribution from def: "x has developmental contribution from y iff x has some part z such that z develops from y" [] xref: RO:0002254 domain: UBERON:0001062 range: UBERON:0001062 holds_over_chain: has_part develops_from is_a: developmentally_preceded_by ! developmentally preceded by inverse_of: developmentally_contributes_to ! developmentally contributes to [Typedef] id: has_developmental_potential_involving name: has developmental potential involving def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." [] xref: RO:0002384 domain: UBERON:0001062 range: UBERON:0001062 is_a: developmentally_related_to ! developmentally related to [Typedef] id: has_disposition name: has disposition def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" [] xref: RO:0000091 domain: BFO:0000004 ! independent continuant range: BFO:0000016 ! disposition is_a: has_characteristic ! has characteristic inverse_of: disposition_of ! disposition of [Typedef] id: has_effector_activity name: has effector activity def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [] xref: RO:0002025 is_functional: true is_a: has_component_activity ! has component activity [Typedef] id: has_end_location name: has end location def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" [] xref: RO:0002232 domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: ends_with occurs_in is_a: has_part_that_occurs_in ! has part that occurs in [Typedef] id: has_function name: has function def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" [] xref: RO:0000085 domain: BFO:0000004 ! independent continuant range: BFO:0000034 ! function is_a: has_characteristic ! has characteristic [Typedef] id: has_input name: has input def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] xref: RO:0002233 domain: BFO:0000015 ! process holds_over_chain: starts_with has_input is_a: has_participant ! has participant inverse_of: input_of ! input of [Typedef] id: has_intermediate name: has intermediate def: "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" [] xref: RO:0002505 is_a: has_participant ! has participant [Typedef] id: has_ligand name: has ligand def: "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." [] xref: RO:0002019 is_a: has_input ! has input [Typedef] id: has_necessary_component_activity name: has necessary component activity xref: RO:0002016 is_a: has_component_activity ! has component activity is_a: positively_regulated_by ! positively regulated by [Typedef] id: has_negative_regulatory_component_activity name: has negative regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." [] xref: RO:0002014 is_a: has_regulatory_component_activity ! has regulatory component activity is_a: negatively_regulated_by ! negatively regulated by [Typedef] id: has_output name: has output def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." [] xref: RO:0002234 holds_over_chain: ends_with has_output is_a: has_participant ! has participant inverse_of: output_of ! output of [Typedef] id: has_part name: has part def: "a core relation that holds between a whole and its part" [] xref: BFO:0000051 is_transitive: true is_a: overlaps ! overlaps [Typedef] id: has_part_structure_that_is_capable_of name: has part structure that is capable of def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] xref: RO:0002584 holds_over_chain: has_part capable_of is_a: causal_relation_between_material_entity_and_a_process ! causal relation between material entity and a process is_a: functionally_related_to ! functionally related to [Typedef] id: has_part_that_occurs_in name: has part that occurs in def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] xref: RO:0002479 domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: has_part occurs_in [Typedef] id: has_participant name: has participant def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] xref: RO:0000057 domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: has_part has_participant [Typedef] id: has_positive_regulatory_component_activity name: has positive regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." [] xref: RO:0002015 is_a: has_regulatory_component_activity ! has regulatory component activity is_a: positively_regulated_by ! positively regulated by [Typedef] id: has_potential_to_develop_into name: has potential to develop into def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" [] xref: RO:0002387 is_a: has_developmental_potential_involving ! has developmental potential involving [Typedef] id: has_potential_to_developmentally_contribute_to name: has potential to developmentally contribute to def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" [] xref: RO:0002385 is_a: has_developmental_potential_involving ! has developmental potential involving [Typedef] id: has_potential_to_directly_develop_into name: has potential to directly develop into def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] xref: RO:0002388 is_a: has_potential_to_develop_into ! has potential to develop into [Typedef] id: has_primary_input name: has primary input def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [] xref: RO:0004009 is_a: has_input ! has input is_a: has_primary_input_or_output ! has primary input or output [Typedef] id: has_primary_input_or_output name: has primary input or output def: "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." [] xref: RO:0004007 is_a: has_participant ! has participant [Typedef] id: has_primary_output name: has primary output def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [] xref: RO:0004008 is_a: has_output ! has output is_a: has_primary_input_or_output ! has primary input or output [Typedef] id: has_quality name: has quality def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] xref: RO:0000086 range: BFO:0000019 ! quality is_a: has_characteristic ! has characteristic [Typedef] id: has_regulatory_component_activity name: has regulatory component activity def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." [] xref: RO:0002013 is_a: has_component_activity ! has component activity is_a: regulated_by ! regulated by [Typedef] id: has_role name: has role def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" [] xref: RO:0000087 domain: BFO:0000004 ! independent continuant range: BFO:0000023 ! role is_a: has_characteristic ! has characteristic [Typedef] id: has_small_molecule_activator name: has small molecule activator def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" [] xref: RO:0012001 is_a: has_small_molecule_regulator ! has small molecule regulator inverse_of: is_small_molecule_activator_of ! is small molecule activator of [Typedef] id: has_small_molecule_regulator name: has small molecule regulator def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" [] xref: RO:0012000 is_a: has_participant ! has participant inverse_of: is_small_molecule_regulator_of ! is small molecule regulator of [Typedef] id: has_start_location name: has start location def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" [] xref: RO:0002231 domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: starts_with occurs_in is_a: has_part_that_occurs_in ! has part that occurs in [Typedef] id: has_target_end_location name: has target end location def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." [] xref: RO:0002339 is_a: results_in_transport_to_from_or_in ! results in transport to from or in transitive_over: part_of ! part of [Typedef] id: has_target_start_location name: has target start location def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." [] xref: RO:0002338 is_a: results_in_transport_to_from_or_in ! results in transport to from or in transitive_over: part_of ! part of [Typedef] id: immediately_causally_downstream_of name: immediately causally downstream of xref: RO:0002405 is_a: causally_downstream_of ! causally downstream of is_a: immediately_preceded_by ! immediately preceded by inverse_of: immediately_causally_upstream_of ! immediately causally upstream of [Typedef] id: immediately_causally_upstream_of name: immediately causally upstream of def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." [] xref: RO:0002412 is_a: causally_upstream_of ! causally upstream of is_a: immediately_precedes ! immediately precedes [Typedef] id: immediately_preceded_by name: immediately preceded by xref: RO:0002087 holds_over_chain: starts_with ends_with is_a: preceded_by ! preceded by inverse_of: immediately_precedes ! immediately precedes [Typedef] id: immediately_precedes name: immediately precedes xref: RO:0002090 holds_over_chain: ends_with starts_with is_a: precedes ! precedes [Typedef] id: in_taxon name: in taxon def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." [] xref: RO:0002162 range: OBI:0100026 holds_over_chain: capable_of in_taxon holds_over_chain: develops_from in_taxon holds_over_chain: has_developmental_contribution_from in_taxon holds_over_chain: has_part in_taxon holds_over_chain: part_of in_taxon holds_over_chain: results_in_developmental_progression_of in_taxon is_a: evolutionarily_related_to ! evolutionarily related to [Typedef] id: indirectly_causally_upstream_of name: indirectly causally upstream of def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." [] xref: RO:0012011 is_a: causally_upstream_of ! causally upstream of [Typedef] id: indirectly_negatively_regulates name: indirectly negatively regulates def: "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." [] xref: RO:0002409 holds_over_chain: directly_negatively_regulates directly_negatively_regulates holds_over_chain: directly_negatively_regulates indirectly_negatively_regulates is_transitive: true is_a: indirectly_regulates ! indirectly regulates is_a: negatively_regulates ! negatively regulates transitive_over: directly_negatively_regulates ! directly negatively regulates [Typedef] id: indirectly_positively_regulates name: indirectly positively regulates def: "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." [] xref: RO:0002407 holds_over_chain: directly_positively_regulates directly_positively_regulates holds_over_chain: directly_positively_regulates indirectly_positively_regulates holds_over_chain: indirectly_negatively_regulates indirectly_negatively_regulates is_transitive: true is_a: indirectly_regulates ! indirectly regulates is_a: positively_regulates ! positively regulates transitive_over: directly_positively_regulates ! directly positively regulates [Typedef] id: indirectly_regulates name: indirectly regulates def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." [] xref: RO:0012012 is_a: indirectly_causally_upstream_of ! indirectly causally upstream of is_a: regulates ! regulates [Typedef] id: input_of name: input of def: "inverse of has input" [] xref: RO:0002352 is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in [Typedef] id: interacts_with name: interacts with def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] synonym: "in pairwise interaction with" EXACT [] xref: RO:0002434 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_symmetric: true [Typedef] id: involved_in name: involved in def: "c involved_in p if and only if c enables some process p', and p' is part of p" [] xref: RO:0002331 holds_over_chain: enables part_of is_a: involved_in_or_involved_in_regulation_of ! involved in or involved in regulation of is_a: participates_in ! participates in transitive_over: part_of ! part of [Typedef] id: involved_in_negative_regulation_of name: involved in negative regulation of def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" [] xref: RO:0002430 holds_over_chain: enables negatively_regulates holds_over_chain: involved_in negatively_regulates is_a: involved_in_regulation_of ! involved in regulation of [Typedef] id: involved_in_or_involved_in_regulation_of name: involved in or involved in regulation of def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] xref: RO:0002431 is_a: acts_upstream_of_or_within ! acts upstream of or within is_a: causal_agent_in_process ! causal agent in process is_a: functionally_related_to ! functionally related to [Typedef] id: involved_in_positive_regulation_of name: involved in positive regulation of def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" [] xref: RO:0002429 holds_over_chain: enables positively_regulates holds_over_chain: involved_in positively_regulates is_a: involved_in_regulation_of ! involved in regulation of [Typedef] id: involved_in_regulation_of name: involved in regulation of def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" [] xref: RO:0002428 holds_over_chain: enables regulates holds_over_chain: involved_in regulates is_a: acts_upstream_of ! acts upstream of is_a: involved_in_or_involved_in_regulation_of ! involved in or involved in regulation of [Typedef] id: is_active_in name: is active in def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [] synonym: "enables activity in" EXACT [] xref: RO:0002432 holds_over_chain: enables occurs_in is_a: functionally_related_to ! functionally related to is_a: overlaps ! overlaps [Typedef] id: is_small_molecule_activator_of name: is small molecule activator of def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" [] xref: RO:0012005 is_a: capable_of_positively_regulating ! capable of positively regulating is_a: is_small_molecule_regulator_of ! is small molecule regulator of [Typedef] id: is_small_molecule_regulator_of name: is small molecule regulator of def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" [] xref: RO:0012004 is_a: capable_of_regulating ! capable of regulating [Typedef] id: mereotopologically_related_to name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] xref: RO:0002323 [Typedef] id: molecularly_interacts_with name: molecularly interacts with def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." [] xref: RO:0002436 is_symmetric: true is_a: interacts_with ! interacts with [Typedef] id: negatively_regulated_by name: negatively regulated by def: "inverse of negatively regulates" [] xref: RO:0002335 is_a: regulated_by ! regulated by [Typedef] id: negatively_regulates name: negatively regulates def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." [] xref: RO:0002212 holds_over_chain: ends_with negatively_regulates is_a: causally_upstream_of,_negative_effect ! causally upstream of, negative effect is_a: regulates ! regulates inverse_of: negatively_regulated_by ! negatively regulated by [Typedef] id: negatively_regulates_characteristic name: negatively regulates characteristic def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." [] xref: RO:0019002 holds_over_chain: negatively_regulates positively_regulates_characteristic holds_over_chain: positively_regulates negatively_regulates_characteristic is_a: regulates_characteristic ! regulates characteristic [Typedef] id: occurs_across name: occurs across def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." [] xref: RO:0002021 is_a: has_part_that_occurs_in ! has part that occurs in [Typedef] id: occurs_in name: occurs in def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] xref: BFO:0000066 domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: part_of occurs_in inverse_of: contains_process ! contains process transitive_over: part_of ! part of [Typedef] id: only_in_taxon name: only in taxon def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] xref: RO:0002160 is_a: in_taxon ! in taxon [Typedef] id: output_of name: output of def: "inverse of has output" [] xref: RO:0002353 is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in [Typedef] id: overlaps name: overlaps def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] xref: RO:0002131 holds_over_chain: has_part overlaps holds_over_chain: has_part part_of holds_over_chain: part_of part_of is_symmetric: true is_a: mereotopologically_related_to ! mereotopologically related to transitive_over: part_of ! part of [Typedef] id: part_of name: part of def: "a core relation that holds between a part and its whole" [] xref: BFO:0000050 is_transitive: true is_a: overlaps ! overlaps inverse_of: has_part ! has part [Typedef] id: part_of_structure_that_is_capable_of name: part of structure that is capable of def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] xref: RO:0002329 holds_over_chain: part_of capable_of is_a: functionally_related_to ! functionally related to [Typedef] id: participates_in name: participates in def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] xref: RO:0000056 domain: BFO:0000002 ! continuant range: BFO:0000003 ! occurrent inverse_of: has_participant ! has participant [Typedef] id: phosphorylates name: phosphorylates xref: RO:0002447 is_a: molecularly_interacts_with ! molecularly interacts with [Typedef] id: positively_regulated_by name: positively regulated by def: "inverse of positively regulates" [] xref: RO:0002336 is_a: regulated_by ! regulated by [Typedef] id: positively_regulates name: positively regulates def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." [] xref: RO:0002213 holds_over_chain: ends_with positively_regulates holds_over_chain: negatively_regulates negatively_regulates is_transitive: true is_a: causally_upstream_of,_positive_effect ! causally upstream of, positive effect is_a: regulates ! regulates inverse_of: positively_regulated_by ! positively regulated by [Typedef] id: positively_regulates_characteristic name: positively regulates characteristic def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." [] xref: RO:0019001 holds_over_chain: positively_regulates positively_regulates_characteristic is_a: regulates_characteristic ! regulates characteristic [Typedef] id: preceded_by name: preceded by def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] xref: BFO:0000062 domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: happens_during preceded_by holds_over_chain: part_of preceded_by holds_over_chain: starts_during preceded_by is_transitive: true is_a: ends_after ! ends after inverse_of: precedes ! precedes [Typedef] id: precedes name: precedes def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] xref: BFO:0000063 domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: happens_during precedes holds_over_chain: part_of precedes is_transitive: true is_a: temporally_related_to ! temporally related to [Typedef] id: process_has_causal_agent name: process has causal agent def: "Inverse of 'causal agent in process'" [] xref: RO:0002608 is_a: causally_related_to ! causally related to [Typedef] id: produced_by name: produced by def: "a produced_by b iff some process that occurs_in b has_output a." [] xref: RO:0003001 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity [Typedef] id: produces name: produces def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] xref: RO:0003000 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity inverse_of: produced_by ! produced by [Typedef] id: quality_of name: quality of def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] xref: RO:0000080 is_a: characteristic_of ! characteristic of inverse_of: has_quality ! has quality [Typedef] id: regulated_by name: regulated by def: "inverse of regulates" [] xref: RO:0002334 domain: BFO:0000015 ! process range: BFO:0000015 ! process is_transitive: true is_a: causally_downstream_of_or_within ! causally downstream of or within [Typedef] id: regulates name: regulates def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." [] xref: RO:0002211 domain: BFO:0000015 ! process range: BFO:0000015 ! process holds_over_chain: directly_regulates directly_regulates holds_over_chain: ends_with regulates is_transitive: true is_a: causally_upstream_of ! causally upstream of inverse_of: regulated_by ! regulated by transitive_over: has_effector_activity ! has effector activity [Typedef] id: regulates_activity_of name: regulates activity of def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." [] xref: RO:0011002 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: causally_influences ! causally influences [Typedef] id: regulates_characteristic name: regulates characteristic def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." [] xref: RO:0019000 domain: BFO:0000015 ! process range: PATO:0000001 holds_over_chain: regulates regulates_characteristic is_a: causally_related_to ! causally related to [Typedef] id: regulates_in_other_organism name: regulates in other organism def: "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." [] xref: RO:0002010 domain: BFO:0000015 ! process range: BFO:0000015 ! process is_a: causally_upstream_of_or_within ! causally upstream of or within [Typedef] id: regulates_levels_of name: regulates levels of def: "p regulates levels of c if p regulates some amount (PATO:0000070) of c" [] xref: RO:0002332 domain: BFO:0000015 ! process range: BFO:0000040 ! material entity is_a: functionally_related_to ! functionally related to [Typedef] id: related_via_localization_to name: related via localization to def: "A relationship that holds via some process of localization" [] xref: RO:0002337 domain: BFO:0000015 ! process range: BFO:0000002 ! continuant [Typedef] id: results_in_acquisition_of_features_of name: results in acquisition of features of def: "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" [] xref: RO:0002315 range: UBERON:0000061 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_assembly_of name: results in assembly of xref: RO:0002588 is_a: results_in_formation_of ! results in formation of is_a: results_in_organization_of ! results in organization of [Typedef] id: results_in_breakdown_of name: results in breakdown of def: "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" [] xref: RO:0002586 is_a: has_input ! has input [Typedef] id: results_in_changes_to_anatomical_or_cellular_structure name: results in changes to anatomical or cellular structure def: "p has anatomical participant c iff p has participant c, and c is an anatomical entity" [] xref: RO:0040036 is_a: has_participant ! has participant [Typedef] id: results_in_commitment_to name: results in commitment to def: "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." [] xref: RO:0002348 range: CL:0000000 is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_determination_of name: results in determination of def: "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." [] xref: RO:0002349 range: CL:0000000 is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_development_of name: results in development of def: "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." [] xref: RO:0002296 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_developmental_progression_of name: results in developmental progression of def: "p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." [] xref: RO:0002295 domain: GO:0008150 range: UBERON:0001062 is_a: developmentally_related_to ! developmentally related to [Typedef] id: results_in_disassembly_of name: results in disassembly of xref: RO:0002590 is_a: results_in_breakdown_of ! results in breakdown of is_a: results_in_organization_of ! results in organization of [Typedef] id: results_in_formation_of name: results in formation of xref: RO:0002297 is_a: has_output ! has output is_a: results_in_developmental_progression_of ! results in developmental progression of inverse_of: formed_as_result_of ! formed as result of [Typedef] id: results_in_fusion_of name: results in fusion of xref: RO:0012008 is_a: results_in_organization_of ! results in organization of [Typedef] id: results_in_growth_of name: results in growth of xref: RO:0002343 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_maturation_of name: results in maturation of def: "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." [] xref: RO:0002299 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_morphogenesis_of name: results in morphogenesis of def: "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." [] xref: RO:0002298 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_movement_of name: results in movement of def: "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" [] xref: RO:0002565 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure [Typedef] id: results_in_organization_of name: results in organization of def: "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" [] xref: RO:0002592 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure [Typedef] id: results_in_remodeling_of name: results in remodeling of xref: RO:0002591 is_a: has_input ! has input is_a: results_in_organization_of ! results in organization of [Typedef] id: results_in_specification_of name: results in specification of def: "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " [] xref: RO:0002356 range: CL:0000000 is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_structural_organization_of name: results in structural organization of def: "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." [] xref: RO:0002355 is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure is_a: results_in_developmental_progression_of ! results in developmental progression of [Typedef] id: results_in_transport_across name: results in transport across def: "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." [] xref: RO:0002342 is_a: occurs_across ! occurs across is_a: results_in_transport_to_from_or_in ! results in transport to from or in [Typedef] id: results_in_transport_along name: results in transport along def: "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " [] xref: RO:0002341 is_a: related_via_localization_to ! related via localization to [Typedef] id: results_in_transport_to_from_or_in name: results in transport to from or in xref: RO:0002344 is_a: related_via_localization_to ! related via localization to [Typedef] id: role_of name: role of def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" [] xref: RO:0000081 is_a: characteristic_of ! characteristic of inverse_of: has_role ! has role [Typedef] id: spatially_disjoint_from name: spatially disjoint from def: "A is spatially_disjoint_from B if and only if they have no parts in common" [] xref: RO:0002163 is_a: mereotopologically_related_to ! mereotopologically related to [Typedef] id: starts name: starts def: "inverse of starts with" [] xref: RO:0002223 is_a: part_of ! part of is_a: temporally_related_to ! temporally related to inverse_of: starts_with ! starts with [Typedef] id: starts_during name: starts during xref: RO:0002091 domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: temporally_related_to ! temporally related to [Typedef] id: starts_with name: starts with def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] xref: RO:0002224 is_transitive: true is_a: has_part ! has part is_a: temporally_related_to ! temporally related to [Typedef] id: temporally_related_to name: temporally related to xref: RO:0002222 domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent [Typedef] id: transformation_of name: transformation of def: "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" [] xref: RO:0002494 is_transitive: true is_a: develops_from ! develops from